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MRGPRX2 Gene

protein-coding   GIFtS: 49
GCID: GC11M019077

MAS-Related GPR, Member X2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MAS-Related GPR, Member X21 2
MRGX22 3 5
MGRG32
G Protein-Coupled Receptor MRGX22
Mas-Related G Protein-Coupled Receptor G32
Mas-Related G-Protein Coupled Receptor Member X22

External Ids:    HGNC: 179831   Entrez Gene: 1171942   Ensembl: ENSG000001836957   OMIM: 6072285   UniProtKB: Q96LB13   

Export aliases for MRGPRX2 gene to outside databases

Previous GC identifers: GC11M019033 GC11M018759


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MRGPRX2 Gene:
MRGPRX2 (MAS-related GPR, member X2) is a protein-coding gene. GO annotations related to this gene include neuropeptide binding and G-protein coupled receptor activity. An important paralog of this gene is MRGPRX3.

UniProtKB/Swiss-Prot: MRGX2_HUMAN, Q96LB1
Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor
function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high
potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation
locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in
intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this
receptor is G(q)-coupled

Gene Wiki entry for MRGPRX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRGPRX2 gene promoter:
         HEN1   Tal-1   p53   Ik-3   HNF-3beta   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRGPRX2 promoter sequence
   Search Chromatin IP Primers for MRGPRX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRGPRX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

MRGPRX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRGPRX2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M019077:  view genomic region     (about GC identifiers)

Start:
19,076,002 bp from pter      End:
19,082,228 bp from pter
Size:
6,227 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MRGX2_HUMAN, Q96LB1 (See protein sequence)
Recommended Name: Mas-related G-protein coupled receptor member X2  
Size: 330 amino acids; 37099 Da
Secondary accessions: B5B0C7 Q4QXW4 Q4QXW7 Q4QXX0 Q4QXX2 Q4QXX3 Q4QXX4 Q4QXX6 Q4QXX7

Explore the universe of human proteins at neXtProt for MRGPRX2: NX_Q96LB1

Explore proteomics data for MRGPRX2 at MOPED


See MRGPRX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_473371.1  
ENSEMBL proteins: 
 ENSP00000333800  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
GPCRAO: GPCR / Class A : Orphans

IUPHAR Guide to PHARMACOLOGY protein family classification: MRGPRX2
Class A Orphans

4 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR026234 MRGPCRFAMILY
 IPR027341 MRGPCRX2
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q96LB1

ProtoNet protein and cluster: Q96LB1

UniProtKB/Swiss-Prot: MRGX2_HUMAN, Q96LB1
Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily


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(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MRGX2_HUMAN, Q96LB1
Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor
function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high
potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation
locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in
intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this
receptor is G(q)-coupled

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IDA12915402
GO:0042923neuropeptide binding IPI12915402
     
Find genes that share ontologies with MRGPRX2           About GenesLikeMe


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRGPRX2
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MRGX2_HUMAN, Q96LB1: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0016021integral component of membrane IC12915402

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Array including MRGPRX2: 
          G Protein Coupled Receptors 384HT in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for MRGPRX2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for MRGPRX2 (ENSP000003338004) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CORTENSP000003662484STRING: ENSP00000366248
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0019233sensory perception of pain NAS12915402
GO:0030431sleep NAS12915402
GO:0032467positive regulation of cytokinesis IMP--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MRGPRX2 (MRGX2)

1 HMDB Compound for MRGPRX2    About this table
CompoundSynonyms CAS #PubMed Ids
Cyclic AMPCyclic AMP (see all 19)60-92-4--

4 IUPHAR Ligands for MRGPRX2 (MRGPRX2)    About this table
LigandTypeActionAffinityPubmed IDs
PAMP-12 (human)
AgonistFull agonist7.24 - 7.6815823563
CST-14
AgonistFull agonist6.9 - 7.623396314 15823563 12915402
compound 2 [PMID:19230660]
AgonistFull agonist6.519230660
PAMP-20
AgonistFull agonist6.515823563



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MRGPRX2 gene: 
NM_054030.2  

Unigene Cluster for MRGPRX2:

MAS-related GPR, member X2
Hs.350566  [show with all ESTs]
Unigene Representative Sequence: BC063450
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000329773(uc001mph.3)
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  QuantiFast Probe-based Assays in human, mouse, rat MRGPRX2

Additional mRNA sequence: BC063450.1 

1 DOTS entry:

DT.95294313 

4 AceView cDNA sequences:

BI828553 NM_054030 BC063450 AF003828 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MRGPRX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTCTTGGAGG
MRGPRX2 Expression
About this image

MRGPRX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MRGPRX2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.350566

UniProtKB/Swiss-Prot: MRGX2_HUMAN, Q96LB1
Tissue specificity: Has a limited expression profile, both peripheral and within the central nervous system, with
highest levels in dorsal root ganglion

    Pathway & Disease-focused RT2 Profiler PCR Array including MRGPRX2: 
          G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX2 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mrgprx21 , 5 MAS-related GPR, member X21, 5 66.87(n)1
56.52(a)1
  7 (31.11 cM)5
2439781  NM_001034868.31  NP_001030040.21 
 484786195 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
23(a)
1 → many
JH376180.1(56001-57008)
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 16)
Uncharacterized protein
(see all 16)
33(a)
33(a)
(see all 16)
many ↔ many
many ↔ many
(see all 16)
4(16394563-16395360)
4(16384879-16387025)


ENSEMBL Gene Tree for MRGPRX2 (if available)
TreeFam Gene Tree for MRGPRX2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MRGPRX2 gene
MRGPRX32  MRGPRD2  MRGPRG2  MAS12  MAS1L2  MRGPRF2  MRGPRX42  MRGPRX12  
MRGPRE2  
9 SIMAP similar genes for MRGPRX2 using alignment to 1 protein entry:     MRGX2_HUMAN:
MRGPRX1    MRGPRX4    MRGPRX3    MAS1    MRGPRD    MRGPRF
MRGPRE    MAS1L    MRGPRG

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2 Pseudogenes.org Pseudogenes for MRGPRX2
PGOHUM00000242606 PGOHUM00000242610


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MRGPRX2 (see all 251)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1129500591,2
C,F--18759376(+) ACAAAG/AAGACT 1 -- int11Minor allele frequency- A:0.50CSA 2
rs110249681,2
C,F,H--19075627(+) TCAGCT/CTTATG 1 -- int110Minor allele frequency- C:0.02NS EA NA 1102
rs1430472631,2
--19075782(+) GTTGAC/TTGAAA 1 -- int10--------
rs1391509511,2
C--19075888(+) GTCAC-/ATA   
   GGTGT
ATTCA
1 -- int10--------
rs1177255911,2
C,F--19075930(+) CATTTA/GTGATC 1 -- int11Minor allele frequency- G:0.01NA 120
rs1153117971,2
C,F--19075996(+) AAGATG/ACAGCA 1 -- int11Minor allele frequency- A:0.11WA 118
rs128000581,2
C,F--19076012(+) AATTAG/ATATTT 1 -- ut316Minor allele frequency- A:0.29NA CSA EA 248
rs1866049991,2
--19076055(+) GTGCAA/GTTTAA 1 -- ut310--------
rs1913368771,2
--19076098(+) TAAAAA/GGTAAA 1 -- ut310--------
rs1838784751,2
--19076099(+) AAAAGG/TTAAAT 1 -- ut310--------

HapMap Linkage Disequilibrium report for MRGPRX2 (19076002 - 19082228 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for MRGPRX2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv897030CNV Loss21882294
nsv428250CNV Gain18775914
dgv347e1CNV Complex17122850

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MRGPRX2
DNA2.0 Custom Variant and Variant Library Synthesis for MRGPRX2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607228    OMIM disorders: --


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Genetic Association Database (GAD): MRGPRX2

Export disorders for MRGPRX2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MRGPRX2 gene, integrated from 10 sources (see all 20):
(articles sorted by number of sources associating them with MRGPRX2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PubMed id 11551509)1, 2, 3 Dong X.... Anderson D.J. (Cell 2001)
  2. Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception. (PubMed id 15862286)1, 2, 9 Yang S.... Su B. (Gene 2005)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. (PubMed id 12915402)1, 2 Robas N.... Fidock M. (J. Biol. Chem. 2003)
  5. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (FEBS Lett. 2002)
  6. Angiotensin metabolites can stimulate receptors of the Mas-related genes family. (PubMed id 18636314)1, 9 Gembardt F....Walther T. (Mol. Cell. Biochem. 2008)
  7. Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes. (PubMed id 24583173)1 Premzl M. (Gene 2014)
  8. I^-Defensins activate human mast cells via Mas-related gene X2. (PubMed id 23698749)1 Subramanian H....Ali H. (J. Immunol. 2013)
  9. Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization. (PubMed id 22069323)1 Subramanian H....Ali H. (J. Biol. Chem. 2011)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 117194 HGNC: 17983 AceView: MRGX2 Ensembl:ENSG00000183695 euGenes: HUgn117194
ECgene: MRGPRX2 H-InvDB: MRGPRX2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MRGPRX2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MRGPRX2 gene:
Search GeneIP for patents involving MRGPRX2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore genomic analysis products

  
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 Block miRNA regulation of human, mouse, rat MRGPRX2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MRGPRX2
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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRGPRX2
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 Search Addgene for plasmids for MRGPRX2
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  eBioscience FlowRNA Probe Sets
       
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