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Aliases for MRGPRX2 Gene

Aliases for MRGPRX2 Gene

  • MAS Related GPR Family Member X2 2 3 5
  • MAS-Related GPR, Member X2 2 3
  • MRGX2 3 4
  • Mas-Related G Protein-Coupled Receptor G3 3
  • G Protein-Coupled Receptor MRGX2 3
  • MGRG3 3

External Ids for MRGPRX2 Gene

Previous GeneCards Identifiers for MRGPRX2 Gene

  • GC11M019033
  • GC11M018759

Summaries for MRGPRX2 Gene

GeneCards Summary for MRGPRX2 Gene

MRGPRX2 (MAS Related GPR Family Member X2) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and mast cell secretagogue receptor activity. An important paralog of this gene is MRGPRX4.

UniProtKB/Swiss-Prot for MRGPRX2 Gene

  • Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.

Gene Wiki entry for MRGPRX2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRX2 Gene

Genomics for MRGPRX2 Gene

Regulatory Elements for MRGPRX2 Gene

Genomic Location for MRGPRX2 Gene

Chromosome:
11
Start:
19,054,455 bp from pter
End:
19,071,978 bp from pter
Size:
17,524 bases
Orientation:
Minus strand

Genomic View for MRGPRX2 Gene

Genes around MRGPRX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGPRX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGPRX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRX2 Gene

Proteins for MRGPRX2 Gene

  • Protein details for MRGPRX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LB1-MRGX2_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor member X2
    Protein Accession:
    Q96LB1
    Secondary Accessions:
    • B5B0C7
    • Q4QXW4
    • Q4QXW7
    • Q4QXX0
    • Q4QXX2
    • Q4QXX3
    • Q4QXX4
    • Q4QXX6
    • Q4QXX7
    • W8W3L5

    Protein attributes for MRGPRX2 Gene

    Size:
    330 amino acids
    Molecular mass:
    37099 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRGPRX2 Gene

Proteomics data for MRGPRX2 Gene at MOPED

Post-translational modifications for MRGPRX2 Gene

No Post-translational modifications

Other Protein References for MRGPRX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MRGPRX2 Gene

Domains & Families for MRGPRX2 Gene

Gene Families for MRGPRX2 Gene

Protein Domains for MRGPRX2 Gene

Suggested Antigen Peptide Sequences for MRGPRX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LB1

UniProtKB/Swiss-Prot:

MRGX2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRX2: view

Function for MRGPRX2 Gene

Molecular function for MRGPRX2 Gene

UniProtKB/Swiss-Prot Function:
Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.

Gene Ontology (GO) - Molecular Function for MRGPRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042923 neuropeptide binding IPI 12915402
genes like me logo Genes that share ontologies with MRGPRX2: view
genes like me logo Genes that share phenotypes with MRGPRX2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRGPRX2 Gene

Localization for MRGPRX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRX2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRGPRX2 Gene COMPARTMENTS Subcellular localization image for MRGPRX2 gene
Compartment Confidence
plasma membrane 5
lysosome 4
vacuole 4
chloroplast 1

No data available for Gene Ontology (GO) - Cellular Components for MRGPRX2 Gene

Pathways & Interactions for MRGPRX2 Gene

SuperPathways for MRGPRX2 Gene

No Data Available

Interacting Proteins for MRGPRX2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000333800%0d%0a9606.ENSP00000366248%0d%0a
Selected Interacting proteins: ENSP00000333800 for MRGPRX2 Gene via STRING

Symbol External ID(s) Details
CORT

SIGNOR curated interactions for MRGPRX2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MRGPRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030431 sleep NAS 12915402
GO:0043303 mast cell degranulation IDA 22069323
GO:0045576 mast cell activation IDA 25517090
genes like me logo Genes that share ontologies with MRGPRX2: view

No data available for Pathways by source for MRGPRX2 Gene

Drugs & Compounds for MRGPRX2 Gene

(5) Drugs for MRGPRX2 Gene - From: IUPHAR, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
compound 2 [PMID:19230660] Pharma Full agonist, Agonist 0
PAMP-12 (human) Pharma Full agonist, Agonist 0
PAMP-20 Pharma Full agonist, Agonist 0
CORTISTATIN-14 Pharma 0

(1) Additional Compounds for MRGPRX2 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CST-14
Full agonist, Agonist
genes like me logo Genes that share compounds with MRGPRX2: view

Transcripts for MRGPRX2 Gene

mRNA/cDNA for MRGPRX2 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGPRX2 Gene

MAS-related GPR, member X2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRX2 Gene

No ASD Table

Relevant External Links for MRGPRX2 Gene

GeneLoc Exon Structure for
MRGPRX2
ECgene alternative splicing isoforms for
MRGPRX2

Expression for MRGPRX2 Gene

mRNA expression in normal human tissues for MRGPRX2 Gene

mRNA differential expression in normal tissues according to GTEx for MRGPRX2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x8.3), Skin - Not Sun Exposed (Suprapubic) (x7.7), and Adipose - Subcutaneous (x5.9).

Protein differential expression in normal tissues from HIPED for MRGPRX2 Gene

This gene is overexpressed in Liver, secretome (48.4) and Heart (20.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MRGPRX2 Gene



SOURCE GeneReport for Unigene cluster for MRGPRX2 Gene Hs.350566

mRNA Expression by UniProt/SwissProt for MRGPRX2 Gene

Q96LB1-MRGX2_HUMAN
Tissue specificity: Mainly expressed in mast cells. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion (PubMed:12915402). Detected in blood vessels, scattered lymphocytes, and gastrointestinal ganglia (at protein level) (PubMed:16161007).
genes like me logo Genes that share expression patterns with MRGPRX2: view

Protein tissue co-expression partners for MRGPRX2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MRGPRX2 Gene

Orthologs for MRGPRX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRGPRX2 35
  • 73.09 (n)
  • 59.33 (a)
MRGPRX2 36
  • 57 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MRGPRX2 35
  • 75.18 (n)
  • 62.01 (a)
-- 36
  • 62 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mrgprx2 35
  • 66.87 (n)
  • 56.52 (a)
Mrgprx2 16
Mrgpra1 36
  • 50 (a)
ManyToMany
Mrgpra2a 36
  • 46 (a)
ManyToMany
Mrgpra2b 36
  • 47 (a)
ManyToMany
Mrgpra3 36
  • 50 (a)
ManyToMany
Mrgpra4 36
  • 50 (a)
ManyToMany
Mrgpra6 36
  • 50 (a)
ManyToMany
Mrgprb1 36
  • 49 (a)
ManyToMany
Mrgprb2 36
  • 50 (a)
ManyToMany
Mrgprb3 36
  • 43 (a)
ManyToMany
Mrgprb4 36
  • 49 (a)
ManyToMany
Mrgprb5 36
  • 48 (a)
ManyToMany
Mrgprb8 36
  • 41 (a)
ManyToMany
Mrgprx1 36
  • 50 (a)
ManyToMany
Mrgprx2 36
  • 51 (a)
ManyToMany
Mrgprx3-ps 36
  • 53 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia MRGPRX2 35
  • 98.58 (n)
  • 96.35 (a)
MRGPRX2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrgprx2 35
  • 69.38 (n)
  • 60.78 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
Species with no ortholog for MRGPRX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRX2 Gene

ENSEMBL:
Gene Tree for MRGPRX2 (if available)
TreeFam:
Gene Tree for MRGPRX2 (if available)

Paralogs for MRGPRX2 Gene

Paralogs for MRGPRX2 Gene

(9) SIMAP similar genes for MRGPRX2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MRGPRX2 Gene

genes like me logo Genes that share paralogs with MRGPRX2: view

Variants for MRGPRX2 Gene

Sequence variations from dbSNP and Humsavar for MRGPRX2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10833049 - 19,056,218(+) AGGCG(C/G/T)TCCTG reference, missense
rs11024970 - 19,056,357(+) TCCAT(G/T)CACTG reference, missense
rs79763999 - 19,056,171(+) GAGGA(A/G)GAGGA reference, missense
rs11823569 - 19,056,276(+) CCCGA(C/T)CAGGG reference, missense
rs905553 -- 19,061,432(-) TCTGA(C/T)TGTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRGPRX2 Gene

Variant ID Type Subtype PubMed ID
dgv347e1 CNV Complex 17122850
nsv428250 CNV Gain 18775914
nsv897030 CNV Loss 21882294

Variation tolerance for MRGPRX2 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.71; 89.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRGPRX2 Gene

HapMap Linkage Disequilibrium report
MRGPRX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRGPRX2 Gene

Disorders for MRGPRX2 Gene

Relevant External Links for MRGPRX2

Genetic Association Database (GAD)
MRGPRX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRGPRX2

No disorders were found for MRGPRX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGPRX2 Gene

Publications for MRGPRX2 Gene

  1. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PMID: 11551509) Dong X. … Anderson D.J. (Cell 2001) 2 3 4 67
  2. Angiotensin metabolites can stimulate receptors of the Mas-related genes family. (PMID: 18636314) Gembardt F. … Walther T. (Mol. Cell. Biochem. 2008) 3 23
  3. Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception. (PMID: 15862286) Yang S. … Su B. (Gene 2005) 3 23
  4. Identification of a mast-cell-specific receptor crucial for pseudo- allergic drug reactions. (PMID: 25517090) McNeil B.D. … Dong X. (Nature 2015) 3
  5. Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes. (PMID: 24583173) Premzl M. (Gene 2014) 3

Products for MRGPRX2 Gene

Sources for MRGPRX2 Gene

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