MRGPRX2 Gene
protein-coding GIFtS: 48
GCID: GC11M019077
|
|
MAS-related GPR, member X2
| |
Aliases
for MRGPRX2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MAS-Related GPR, Member X21 2 | | MRGX21 2 3 5 | | G Protein-Coupled Receptor MRGX22 | | Mas-Related G-Protein Coupled Receptor Member X22 |
Export aliases for MRGPRX2 gene to outside databasesPrevious GC identifers: GC11M019033 GC11M018759 |
Summaries
for MRGPRX2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MRGX2_HUMAN, Q96LB1Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor functionand/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand atthis receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity,and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but hadno effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled
Gene Wiki entry for MRGPRX2
|
Genomic Views
for MRGPRX2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRGPRX2 gene promoter:
HEN1 Tal-1 p53 Ik-3 HNF-3beta Tal-1beta E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRGPRX2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRGPRX2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.1 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p15.1MRGPRX2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M019077: view genomic region
(about GC identifiers)
Start:
|
19,076,002 bp from pter |
End:
|
19,082,228 bp from pter |
Size:
|
6,227 bases |
Orientation:
|
minus strand |
|
Proteins
for MRGPRX2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MRGX2_HUMAN, Q96LB1 (See
protein sequence)Recommended Name: Mas-related G-protein coupled receptor member X2 Size: 330 amino acids; 37099 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B5B0C7 Q4QXW4 Q4QXW7 Q4QXX0 Q4QXX2 Q4QXX3 Q4QXX4 Q4QXX6 Q4QXX7Explore the universe of human proteins at neXtProt for MRGPRX2: NX_Q96LB1
MRGPRX2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_473371.1
ENSEMBL proteins: ENSP00000333800
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MRGPRX2 for ontologies About GeneDecksing
MRGPRX2 Antibody Products:
Assay Products for MRGPRX2: |
Protein
Domains /
Families
for MRGPRX2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRGPRX2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96LB1ProtoNet protein and cluster: Q96LB1 UniProtKB/Swiss-Prot: MRGX2_HUMAN, Q96LB1Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily |
Function
for MRGPRX2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MRGX2_HUMAN, Q96LB1Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor functionand/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand atthis receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity,and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but hadno effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled
Clone
Products: |  | EMD Millipore Clones for the Expression of MRGPRX2 | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRX2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRX2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRGPRX2 (NM_054030) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRGPRX2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRGPRX2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRX2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
MRGPRX2 for ontologies About GeneDecksing
|
Pathways & Interactions
for MRGPRX2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRGPRX2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for MRGPRX2 (ENSP000003338004) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
MRGPRX2 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRGPRX2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRGPRX2
1 HMDB Compound for MRGPRX2 About this table
Search CenterWatch for drugs/clinical trials and news about MRGPRX2 / MRGX2
|
Transcripts
for MRGPRX2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRGPRX2 gene: NM_054030.2 Unigene Cluster for MRGPRX2: MAS-related GPR, member X2 Hs.350566 [show with all ESTs]Unigene Representative Sequence: BC0634501 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000329773(uc001mph.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRX2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRX2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRGPRX2 (NM_054030) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRGPRX2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRGPRX2 |
Additional cDNA sequence: BC063450.1 1 DOTS entry: DT.95294313 4 AceView cDNA sequences: NM_054030 BC063450 BI828553 AF003828
GeneLoc Exon Structure
|
Expression
for MRGPRX2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRGPRX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTTGGAGG
About this image
See MRGPRX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRGPRX2
SOURCE GeneReport for Unigene cluster: Hs.350566
UniProtKB/Swiss-Prot: MRGX2_HUMAN, Q96LB1Tissue specificity: Has a limited expression profile, both peripheral and within the central nervous system, withhighest levels in dorsal root ganglion
SABiosciences Expression via Pathway-Focused PCR Array including MRGPRX2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRGPRX2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRGPRX2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRGPRX2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRGPRX2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRX2 |
Orthologs
for MRGPRX2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MRGPRX2 gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for MRGPRX2 (if available)
TreeFam Gene Tree for MRGPRX2 (if available) |
Paralogs
for MRGPRX2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRGPRX2 gene
- MRGPRX32 MRGPRX12 MRGPRD2 MRGPRE2 MRGPRG2 MAS12 MAS1L2 MRGPRF2
- MRGPRX42
9 SIMAP similar genes for MRGPRX2 using alignment to 1 protein entry: MRGX2_HUMAN:MRGPRX1 MRGPRX4 MRGPRX3 MAS1 MRGPRD MRGPRF
MRGPRE MAS1L MRGPRG
MRGPRX2 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for MRGPRX2
PGOHUM00000242606 PGOHUM00000242610
|
Genomic Variants
for MRGPRX2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRGPRX2 (19076002 - 19082228 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MRGPRX2
1 CNV: 3838 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRGPRX2 |
|
Disorders
/ Diseases
for MRGPRX2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRGPRX2 for disorders About GeneDecksing
OMIM gene information: 607228
OMIM disorders: --
4  diseases for MRGPRX2: About MalaCardssmall cell carcinoma lung cancer carcinoma neuronitis
Export disorders for MRGPRX2 gene to outside databases
|
Publications
for MRGPRX2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRGPRX2 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with MRGPRX2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PubMed id 11551509)1, 2, 3 Dong X.... Anderson D.J. (2001)
- Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception. (PubMed id 15862286)1, 2, 9 Yang S.... Su B. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. (PubMed id 12915402)1, 2 Robas N.... Fidock M. (2003)
- Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (2002)
- Angiotensin metabolites can stimulate receptors of the Mas-related genes family. (PubMed id 18636314)1, 9 Gembardt F....Walther T. (2008)
- Mas-related gene X2 (MrgX2) is a novel G protein-coupl ed receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization. (PubMed id 22069323)1 Subramanian H....Ali H. (2011)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. (PubMed id 15823563)9 Kamohara M....Katou M. (2005)
- Expression of cortistatin and MrgX2, a specific cortistatin receptor, in human neuroendocrine tissues and related tumours. (PubMed id 16161007)9 Allia E....Papotti M. (2005)
|
External Searches for MRGPRX2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRGPRX2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRGPRX2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRGPRX2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRGPRX2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRGPRX2 gene:
Search GeneIP for patents involving MRGPRX2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRGPRX2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRGPRX2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRGPRX2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRGPRX2 | | | OriGene Protein Over-expression Lysate for MRGPRX2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRGPRX2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRX2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRX2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MRGPRX2 | | OriGene Custom Protein Services for MRGPRX2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRGPRX2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRGPRX2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRGPRX2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRGPRX2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRGPRX2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRGPRX2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MRGPRX2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MRGPRX2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRX2 |
|  |  |  | | | | ThermoFisher Antibodies for MRGPRX2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRGPRX2 |
|
|
|
|
