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Aliases for MRGPRX2 Gene

Aliases for MRGPRX2 Gene

  • MAS-Related GPR, Member X2 2 3
  • MRGX2 3 4 6
  • Mas-Related G-Protein Coupled Receptor Member X2 3
  • Mas-Related G Protein-Coupled Receptor G3 3
  • G Protein-Coupled Receptor MRGX2 3
  • MGRG3 3

External Ids for MRGPRX2 Gene

Previous GeneCards Identifiers for MRGPRX2 Gene

  • GC11M019033
  • GC11M018759

Summaries for MRGPRX2 Gene

GeneCards Summary for MRGPRX2 Gene

MRGPRX2 (MAS-Related GPR, Member X2) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide binding. An important paralog of this gene is MRGPRX4.

UniProtKB/Swiss-Prot for MRGPRX2 Gene

  • Mast cell-specific receptor for basic secretagogues (PubMed:25517090). Basic secretagogues are a set of cationic amphiphilic drugs, as well as endo- and exogenous peptides, which share basic head group combined with a hydrophobic core of the molecule. Recognizes and binds small molecules containing a cyclized a tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium (By similarity). Mediates mast cell responsiveness and side effects of small-molecule therapeutic drugs by acting as a specific receptor for basic secretagogues drugs in mast cells: binding to drugs induces pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of ligands, including peptides: acts as a receptor of cortistatin-14, a regulator of sleep regulation locomotor activity, and cortical function (PubMed:12915402). Acts as a receptor for proadrenomedullin N-terminal peptides PAMP-12, and at lower extent PAMP-20 (PubMed:15823563). Acts as a receptor for antibacterial protein LL-37, promoting chemotaxis, degranulation and chemokine production in mast cells (PubMed:22069323). Acts as a receptor for PMX-53 peptide, a potent antagonist of C5AR1/CD88 (PubMed:21441599). Acts as a receptor for beta-defensins (PubMed:23698749). Acts as a receptor for complanadine A, an alkaloid (PubMed:24930830).

Gene Wiki entry for MRGPRX2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRX2 Gene

Genomics for MRGPRX2 Gene

Regulatory Elements for MRGPRX2 Gene

Genomic Location for MRGPRX2 Gene

Start:
19,054,455 bp from pter
End:
19,060,681 bp from pter
Size:
6,227 bases
Orientation:
Minus strand

Genomic View for MRGPRX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRGPRX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRX2 Gene

Proteins for MRGPRX2 Gene

  • Protein details for MRGPRX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LB1-MRGX2_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor member X2
    Protein Accession:
    Q96LB1
    Secondary Accessions:
    • B5B0C7
    • Q4QXW4
    • Q4QXW7
    • Q4QXX0
    • Q4QXX2
    • Q4QXX3
    • Q4QXX4
    • Q4QXX6
    • Q4QXX7
    • W8W3L5

    Protein attributes for MRGPRX2 Gene

    Size:
    330 amino acids
    Molecular mass:
    37099 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRGPRX2 Gene

Proteomics data for MRGPRX2 Gene at MOPED

Post-translational modifications for MRGPRX2 Gene

No Post-translational modifications

Other Protein References for MRGPRX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MRGPRX2 Gene

Domains for MRGPRX2 Gene

Gene Families for MRGPRX2 Gene

HGNC:
  • GPCRAO :GPCR / Class A : Orphans
IUPHAR :

Protein Domains for MRGPRX2 Gene

Suggested Antigen Peptide Sequences for MRGPRX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LB1

UniProtKB/Swiss-Prot:

MRGX2_HUMAN :
  • Q96LB1
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRX2: view

Function for MRGPRX2 Gene

Molecular function for MRGPRX2 Gene

UniProtKB/Swiss-Prot Function: Mast cell-specific receptor for basic secretagogues (PubMed:25517090). Basic secretagogues are a set of cationic amphiphilic drugs, as well as endo- and exogenous peptides, which share basic head group combined with a hydrophobic core of the molecule. Recognizes and binds small molecules containing a cyclized a tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium (By similarity). Mediates mast cell responsiveness and side effects of small-molecule therapeutic drugs by acting as a specific receptor for basic secretagogues drugs in mast cells: binding to drugs induces pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of ligands, including peptides: acts as a receptor of cortistatin-14, a regulator of sleep regulation locomotor activity, and cortical function (PubMed:12915402). Acts as a receptor for proadrenomedullin N-terminal peptides PAMP-12, and at lower extent PAMP-20 (PubMed:15823563). Acts as a receptor for antibacterial protein LL-37, promoting chemotaxis, degranulation and chemokine production in mast cells (PubMed:22069323). Acts as a receptor for PMX-53 peptide, a potent antagonist of C5AR1/CD88 (PubMed:21441599). Acts as a receptor for beta-defensins (PubMed:23698749). Acts as a receptor for complanadine A, an alkaloid (PubMed:24930830).

Gene Ontology (GO) - Molecular Function for MRGPRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IDA 12915402
GO:0042923 neuropeptide binding IPI 12915402
GO:1990595 mast cell secretagogue receptor activity ISS --
genes like me logo Genes that share ontologies with MRGPRX2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRGPRX2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MRGPRX2 Gene

Localization for MRGPRX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRX2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRGPRX2 Gene COMPARTMENTS Subcellular localization image for MRGPRX2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for MRGPRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IC 12915402
GO:0042629 mast cell granule IDA 22069323
genes like me logo Genes that share ontologies with MRGPRX2: view

Pathways for MRGPRX2 Gene

SuperPathways for MRGPRX2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for MRGPRX2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000333800%0d%0a9606.ENSP00000366248%0d%0a
Selected Interacting proteins: ENSP00000333800 for MRGPRX2 Gene via STRING

Symbol External ID(s) Details
CORT

Gene Ontology (GO) - Biological Process for MRGPRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0019233 sensory perception of pain NAS 12915402
GO:0030431 sleep NAS 12915402
GO:0032467 positive regulation of cytokinesis IMP 22888021
GO:0043303 mast cell degranulation IDA 22069323
genes like me logo Genes that share ontologies with MRGPRX2: view

No data available for Pathways by source for MRGPRX2 Gene

Compounds for MRGPRX2 Gene

(1) HMDB Compounds for MRGPRX2 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4

(4) IUPHAR Ligand for MRGPRX2 Gene

Ligand Type Action Affinity Pubmed IDs
CST-14 Agonist Full agonist 9.9
PAMP-12 (human) Agonist Full agonist 7.68
compound 2 [PMID:19230660] Agonist Full agonist 6.5
PAMP-20 Agonist Full agonist
genes like me logo Genes that share compounds with MRGPRX2: view

Transcripts for MRGPRX2 Gene

mRNA/cDNA for MRGPRX2 Gene

(4) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGPRX2 Gene

MAS-related GPR, member X2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRGPRX2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRX2 Gene

No ASD Table

Relevant External Links for MRGPRX2 Gene

GeneLoc Exon Structure for
MRGPRX2
ECgene alternative splicing isoforms for
MRGPRX2

Expression for MRGPRX2 Gene

mRNA expression in normal human tissues for MRGPRX2 Gene

mRNA differential expression in normal tissues according to GTEx for MRGPRX2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (8.3), Skin - Not Sun Exposed (Suprapubic) (7.7), and Adipose - Subcutaneous (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MRGPRX2 Gene

SOURCE GeneReport for Unigene cluster for MRGPRX2 Gene Hs.350566

mRNA Expression by UniProt/SwissProt for MRGPRX2 Gene

Q96LB1-MRGX2_HUMAN
Tissue specificity: Mainly expressed in mast cells. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion (PubMed:12915402). Detected in blood vessels, scattered lymphocytes, and gastrointestinal ganglia (at protein level) (PubMed:16161007).
genes like me logo Genes that share expressions with MRGPRX2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MRGPRX2 Gene

Orthologs for MRGPRX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRGPRX2 35
  • 98.58 (n)
  • 96.35 (a)
MRGPRX2 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRGPRX2 35
  • 73.09 (n)
  • 59.33 (a)
MRGPRX2 36
  • 57 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 62 (a)
OneToMany
MRGPRX2 35
  • 75.18 (n)
  • 62.01 (a)
mouse
(Mus musculus)
Mammalia Mrgpra1 36
  • 50 (a)
ManyToMany
Mrgpra2a 36
  • 46 (a)
ManyToMany
Mrgpra2b 36
  • 47 (a)
ManyToMany
Mrgpra3 36
  • 50 (a)
ManyToMany
Mrgpra4 36
  • 50 (a)
ManyToMany
Mrgpra6 36
  • 50 (a)
ManyToMany
Mrgprb1 36
  • 49 (a)
ManyToMany
Mrgprb2 36
  • 50 (a)
ManyToMany
Mrgprb3 36
  • 43 (a)
ManyToMany
Mrgprb4 36
  • 49 (a)
ManyToMany
Mrgprb5 36
  • 48 (a)
ManyToMany
Mrgprb8 36
  • 41 (a)
ManyToMany
Mrgprx1 36
  • 50 (a)
ManyToMany
Mrgprx2 35
  • 66.87 (n)
  • 56.52 (a)
Mrgprx2 16
Mrgprx2 36
  • 51 (a)
ManyToMany
Mrgprx3-ps 36
  • 53 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Mrgprx2 35
  • 69.38 (n)
  • 60.78 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
Species with no ortholog for MRGPRX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRX2 Gene

ENSEMBL:
Gene Tree for MRGPRX2 (if available)
TreeFam:
Gene Tree for MRGPRX2 (if available)

Paralogs for MRGPRX2 Gene

Paralogs for MRGPRX2 Gene

Selected SIMAP similar genes for MRGPRX2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MRGPRX2 Gene

genes like me logo Genes that share paralogs with MRGPRX2: view

Variants for MRGPRX2 Gene

Sequence variations from dbSNP and Humsavar for MRGPRX2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs905553 -- 19,061,432(-) TCTGA(C/T)TGTCT upstream-variant-2KB
rs905554 -- 19,061,199(-) AACAT(C/T)GATAA upstream-variant-2KB
rs1503502 -- 19,061,930(-) TCACA(A/G)AAGGA upstream-variant-2KB
rs1503503 -- 19,060,482(-) AGATG(C/G)TGGGA intron-variant
rs1503504 -- 19,057,486(-) AGACA(A/C)TAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRGPRX2 Gene

Variant ID Type Subtype PubMed ID
dgv347e1 CNV Complex 17122850
nsv428250 CNV Gain 18775914
nsv897030 CNV Loss 21882294

Relevant External Links for MRGPRX2 Gene

HapMap Linkage Disequilibrium report
MRGPRX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRGPRX2 Gene

Disorders for MRGPRX2 Gene

Relevant External Links for MRGPRX2

Genetic Association Database (GAD)
MRGPRX2
genes like me logo Genes that share disorders with MRGPRX2: view

No data available for UniProtKB/Swiss-Prot for MRGPRX2 Gene

Publications for MRGPRX2 Gene

  1. Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception. (PMID: 15862286) Yang S. … Su B. (Gene 2005) 3 4 23
  2. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PMID: 11551509) Dong X. … Anderson D.J. (Cell 2001) 2 3 4
  3. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4
  4. I^-Defensins activate human mast cells via Mas-related gene X2. (PMID: 23698749) Subramanian H. … Ali H. (J. Immunol. 2013) 3 4
  5. Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes. (PMID: 24583173) Premzl M. (Gene 2014) 3 4

Products for MRGPRX2 Gene

Sources for MRGPRX2 Gene

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