Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRGPRX2 Gene

protein-coding   GIFtS: 50
GCID: GC11M019077

MAS-Related GPR, Member X2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MAS-Related GPR, Member X21 2
MRGX22 3 5
G Protein-Coupled Receptor MRGX22
Mas-Related G-Protein Coupled Receptor Member X22

External Ids:    HGNC: 179831   Entrez Gene: 1171942   Ensembl: ENSG000001836957   OMIM: 6072285   UniProtKB: Q96LB13   

Export aliases for MRGPRX2 gene to outside databases

Previous GC identifers: GC11M019033 GC11M018759


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MRGPRX2 Gene: 
MRGPRX2 (MAS-related GPR, member X2) is a protein-coding gene. Diseases associated with MRGPRX2 include small cell carcinoma, and lung cancer. GO annotations related to this gene include neuropeptide binding and G-protein coupled receptor activity. An important paralog of this gene is MRGPRX3.

UniProtKB/Swiss-Prot: MRGX2_HUMAN, Q96LB1
Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor
function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high
potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation
locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in
intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this
receptor is G(q)-coupled

Gene Wiki entry for MRGPRX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRGPRX2 gene promoter:
         HEN1   Tal-1   p53   Ik-3   HNF-3beta   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRGPRX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRGPRX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRGPRX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

MRGPRX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRGPRX2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M019077:  view genomic region     (about GC identifiers)

Start:
19,076,002 bp from pter      End:
19,082,228 bp from pter
Size:
6,227 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MRGX2_HUMAN, Q96LB1 (See protein sequence)
Recommended Name: Mas-related G-protein coupled receptor member X2  
Size: 330 amino acids; 37099 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B5B0C7 Q4QXW4 Q4QXW7 Q4QXX0 Q4QXX2 Q4QXX3 Q4QXX4 Q4QXX6 Q4QXX7

Explore the universe of human proteins at neXtProt for MRGPRX2: NX_Q96LB1

Explore proteomics data for MRGPRX2 at MOPED 

MRGPRX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

MRGPRX2 Protein Expression

REFSEQ proteins: NP_473371.1  
ENSEMBL proteins: 
 ENSP00000333800  

Human Recombinant Protein Products for MRGPRX2: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for MRGPRX2
OriGene Custom MassSpec 
OriGene Custom Protein Services for MRGPRX2
GenScript Custom Purified and Recombinant Proteins Services for MRGPRX2
Novus Biologicals MRGPRX2 Protein
Novus Biologicals MRGPRX2 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for MRGPRX2 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0016021integral to membrane IC12915402

MRGPRX2 for ontologies           About GeneDecksing



MRGPRX2 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for MRGPRX2 (MRGX2)
Browse OriGene Antibodies
OriGene Custom Antibody Services for MRGPRX2
GenScript Custom Superior Antibodies Services for MRGPRX2
Novus Biologicals MRGPRX2 Antibodies
Abcam antibodies for MRGPRX2
Cloud-Clone Corp. Antibodies for MRGPRX2 
ThermoFisher Antibodies for MRGPRX2
LSBio Antibodies in human, mouse, rat for MRGPRX2 

Assay Products for MRGPRX2: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for MRGPRX2
Browse R&D Systems for biochemical assays
GenScript MRGPRX2-overexpressing Cell Line for Assay
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for MRGPRX2 
Cloud-Clone Corp. CLIAs for MRGPRX2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
GPCRAO: GPCR / Class A : Orphans

IUPHAR Guide to PHARMACOLOGY protein family classification: MRGPRX2 
Class A Orphans

4 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR026234 MRGPCRFAMILY
 IPR027341 MRGPCRX2
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q96LB1

ProtoNet protein and cluster: Q96LB1

UniProtKB/Swiss-Prot: MRGX2_HUMAN, Q96LB1
Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily


MRGPRX2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: MRGX2_HUMAN, Q96LB1
Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor
function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high
potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation
locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in
intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this
receptor is G(q)-coupled

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IDA12915402
GO:0042923neuropeptide binding IPI12915402
     
MRGPRX2 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for MRGPRX2 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MRGPRX2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRGPRX2 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MRGPRX2 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRGPRX2
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MRGPRX2
SwitchGear 3'UTR luciferase reporter plasmidMRGPRX2 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for MRGPRX2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRGPRX2

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for MRGPRX2
Sirion Biotech Customized adenovirus for overexpression of MRGPRX2

Clone
Products:
     
EMD Millipore Clones for the Expression of MRGPRX2
OriGene clones in human, mouse for MRGPRX2 (see all 6)
OriGene ORF clones in mouse, rat for MRGPRX2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: MRGPRX2 (NM_054030)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRGPRX2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRGPRX2
Sirion Biotech Customized lentivirus for stable overexpression of MRGPRX2 
                     Customized lentivirus expression plasmids for stable overexpression of MRGPRX2 

Cell Line
Products:
     
GenScript MRGPRX2-overexpressing Cell Line for Assay
Search LifeMap BioReagents cell lines for MRGPRX2
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRX2


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRGPRX2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for MRGPRX2 (ENSP000003338004) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CORTENSP000003662484STRING: ENSP00000366248
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0019233sensory perception of pain NAS12915402
GO:0030431sleep NAS12915402

MRGPRX2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MRGPRX2 (MRGX2)

1 HMDB Compound for MRGPRX2    About this table
CompoundSynonyms CAS #PubMed Ids
Cyclic AMPCyclic AMP (see all 19)60-92-4--

4 IUPHAR Ligands for MRGPRX2 (MRGPRX2)    About this table 
LigandTypeActionAffinityPubmed IDs
PAMP-12 (human)
AgonistFull agonist7.24 - 7.6815823563
CST-14
AgonistFull agonist6.9 - 7.623396314 15823563 12915402
compound 2 [PMID:19230660]
AgonistFull agonist6.519230660
PAMP-20
AgonistFull agonist6.515823563

Search CenterWatch for drugs/clinical trials and news about MRGPRX2 / MRGX2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MRGPRX2 gene: 
NM_054030.2  

Unigene Cluster for MRGPRX2:

MAS-related GPR, member X2
Hs.350566  [show with all ESTs]
Unigene Representative Sequence: BC063450
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000329773(uc001mph.3)
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRGPRX2
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MRGPRX2
SwitchGear 3'UTR luciferase reporter plasmidMRGPRX2 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for MRGPRX2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRGPRX2
Clone
Products:
     
OriGene clones in human, mouse for MRGPRX2 (see all 6)
OriGene ORF clones in mouse, rat for MRGPRX2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: MRGPRX2 (NM_054030)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRGPRX2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRGPRX2
Sirion Biotech Customized lentivirus for stable overexpression of MRGPRX2 
                     Customized lentivirus expression plasmids for stable overexpression of MRGPRX2 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for MRGPRX2
OriGene qSTAR qPCR primer pairs in human, mouse for MRGPRX2
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRGPRX2
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRGPRX2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRGPRX2

Additional mRNA sequence: BC063450.1 

1 DOTS entry:

DT.95294313 

4 AceView cDNA sequences:

BI828553 BC063450 NM_054030 AF003828 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MRGPRX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTCTTGGAGG
MRGPRX2 Expression
About this image


See MRGPRX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRGPRX2

SOURCE GeneReport for Unigene cluster: Hs.350566

UniProtKB/Swiss-Prot: MRGX2_HUMAN, Q96LB1
Tissue specificity: Has a limited expression profile, both peripheral and within the central nervous system, with
highest levels in dorsal root ganglion

    SABiosciences Expression via Pathway-Focused PCR Array including MRGPRX2: 
          G Protein Coupled Receptors 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for MRGPRX2
OriGene qSTAR qPCR primer pairs in human, mouse for MRGPRX2
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRGPRX2
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRGPRX2
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRGPRX2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRX2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX2 gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mrgprx21 , 5 MAS-related GPR, member X21, 5 66.98(n)1
56.7(a)1
  7 (31.11 cM)5
2439781  NM_001034868.31  NP_001030040.21 
 484786195 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
23(a)
1 → many
JH376180.1(56001-57008)
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 19)
Uncharacterized protein
(see all 19)
33(a)
33(a)
(see all 19)
many ↔ many
many ↔ many
(see all 19)
4(16394563-16395360)
4(16488532-16489341)


ENSEMBL Gene Tree for MRGPRX2 (if available)
TreeFam Gene Tree for MRGPRX2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MRGPRX2 gene
MRGPRX32  MRGPRD2  MRGPRG2  MAS12  MAS1L2  MRGPRF2  MRGPRX42  MRGPRX12  
MRGPRE2  
9 SIMAP similar genes for MRGPRX2 using alignment to 1 protein entry:     MRGX2_HUMAN:
MRGPRX1    MRGPRX4    MRGPRX3    MAS1    MRGPRD    MRGPRF
MRGPRE    MAS1L    MRGPRG

MRGPRX2 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for MRGPRX2
PGOHUM00000242606 PGOHUM00000242610


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/251 SNPs in MRGPRX2 are shown (see all 251)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1129500591,2
C,F--18759376(+) ACAAAG/AAGACT 1 -- int11Minor allele frequency- A:0.50CSA 2
rs110249681,2
C,F,H--19075627(+) TCAGCT/CTTATG 1 -- int110Minor allele frequency- C:0.02NS EA NA 1102
rs1430472631,2
--19075782(+) GTTGAC/TTGAAA 1 -- int10--------
rs1391509511,2
C--19075888(+) GTCAC-/ATA   
   GGTGT
ATTCA
1 -- int10--------
rs1177255911,2
C,F--19075930(+) CATTTA/GTGATC 1 -- int11Minor allele frequency- G:0.01NA 120
rs1153117971,2
C,F--19075996(+) AAGATG/ACAGCA 1 -- int11Minor allele frequency- A:0.11WA 118
rs128000581,2
C,F--19076012(+) AATTAG/ATATTT 1 -- ut316Minor allele frequency- A:0.29NA CSA EA 248
rs1866049991,2
--19076055(+) GTGCAA/GTTTAA 1 -- ut310--------
rs1913368771,2
--19076098(+) TAAAAA/GGTAAA 1 -- ut310--------
rs1838784751,2
--19076099(+) AAAAGG/TTAAAT 1 -- ut310--------

HapMap Linkage Disequilibrium report for MRGPRX2 (19076002 - 19082228 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for MRGPRX2:    About this table     
Variant IDTypeSubtypePubMed ID
nsv897030CNV Loss21882294
nsv428250CNV Gain18775914
dgv347e1CNV Complex17122850

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing MRGPRX2
DNA2.0 Custom Variant and Variant Library Synthesis for MRGPRX2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 607228    OMIM disorders: --

3 diseases for MRGPRX2:    About MalaCards
small cell carcinoma    lung cancer    neuronitis


MRGPRX2 for disorders           About GeneDecksing

Genetic Association Database (GAD): MRGPRX2

Export disorders for MRGPRX2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MRGPRX2 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with MRGPRX2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PubMed id 11551509)1, 2, 3 Dong X.... Anderson D.J. (2001)
  2. Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception. (PubMed id 15862286)1, 2, 9 Yang S.... Su B. (2005)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. (PubMed id 12915402)1, 2 Robas N.... Fidock M. (2003)
  5. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (2002)
  6. Angiotensin metabolites can stimulate receptors of the Mas-related genes family. (PubMed id 18636314)1, 9 Gembardt F....Walther T. (2008)
  7. b-Defensins activate human mast cells via Mas-related gene X2. (PubMed id 23698749)1 Subramanian H....Ali H. (2013)
  8. Mas-related gene X2 (MrgX2) is a novel G protein-coupl ed receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization. (PubMed id 22069323)1 Subramanian H....Ali H. (2011)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  10. Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. (PubMed id 15823563)9 Kamohara M....Katou M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 117194 HGNC: 17983 AceView: MRGX2 Ensembl:ENSG00000183695 euGenes: HUgn117194
ECgene: MRGPRX2 H-InvDB: MRGPRX2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MRGPRX2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MRGPRX2 gene:
Search GeneIP for patents involving MRGPRX2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 Browse Small Molecules at EMD Millipore
 Browse Purified and Recombinant Proteins at EMD Millipore
 Browse Kits and Assays available from EMD Millipore
 Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
 Browse for Gene Knock-down Tools from EMD Millipore
 EMD Millipore Clones for the Expression of MRGPRX2
 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Antibodies for MRGPRX2 (MRGX2)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 cDNA Clones for MRGPRX2 (MRGX2)   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MRGPRX2  
 OriGene qPCR primer pairs and template standards for MRGPRX2   OriGene Protein Over-expression Lysate for MRGPRX2  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for MRGPRX2  
 OriGene qSTAR qPCR primer pairs in human, mouse for MRGPRX2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for MRGPRX2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for MRGPRX2   OriGene Custom Protein Services for MRGPRX2  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRGPRX2
 QIAGEN SeqTarget long-range PCR primers for resequencing MRGPRX2
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRGPRX2
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRGPRX2
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRGPRX2
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRGPRX2
 GenScript Custom Purified and Recombinant Proteins Services for MRGPRX2 GenScript cDNA clones with any tag delivered in your preferred vector for MRGPRX2
 GenScript MRGPRX2-overexpressing Cell Line for Assay GenScript Custom Superior Antibodies Services for MRGPRX2
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in MRGPRX2 promoter
 Search Chromatin IP Primers for MRGPRX2
 RT2 qPCR Primer Assay in human, mouse, rat MRGPRX2
 Search GNC Networks for MRGPRX2
 SABiosciences PCR Arrays including human, mouse, rat MRGPRX2
 Search Tocris compounds for MRGPRX2 (MRGX2)
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 MRGPRX2 antibodies
 MRGPRX2 proteins
 MRGPRX2 lysates
 Antibodies for MRGPRX2
 See all of Abcam's Antibodies, Kits and Proteins for MRGPRX2
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 Proteins for MRGPRX2
 Antibodies for MRGPRX2
 ELISAs for MRGPRX2
 CLIAs for MRGPRX2
 Search LifeMap BioReagents cell lines for MRGPRX2
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRX2
 SwitchGear 3'UTR luciferase reporter plasmids for MRGPRX2
 SwitchGear Promoter luciferase reporter plasmids for MRGPRX2
 ThermoFisher Antibodies for MRGPRX2
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRGPRX2
 inGenious Targeting Laboratory - Custom generated mouse model solutions for MRGPRX2
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MRGPRX2
Customized:
 lentivirus for stable overexpression of MRGPRX2
 lentivirus expression plasmids for stable overexpression of MRGPRX2
 adenovirus for overexpression of MRGPRX2
 LSBio Antibodies in human, mouse, rat for MRGPRX2
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      MRGPRX2 gene at Home site.
hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4