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Aliases for MRGPRX1 Gene

Aliases for MRGPRX1 Gene

  • MAS Related GPR Family Member X1 2 3 5
  • Sensory Neuron-Specific G-Protein Coupled Receptor 3/4 3 4
  • MAS-Related GPR, Member X1 2 3
  • MRGX1 3 4
  • SNSR4 3 4
  • Mas-Related G-Protein Coupled Receptor Member X1 3
  • Mas-Related G Protein-Coupled Receptor G2 3
  • G Protein-Coupled Receptor MRGX1 3
  • G Protein-Coupled Receptor SNSR3 3
  • MGRG2 3
  • SNSR3 4
  • GPCR 3

External Ids for MRGPRX1 Gene

Previous GeneCards Identifiers for MRGPRX1 Gene

  • GC11M018912
  • GC11M018886
  • GC11M018639

Summaries for MRGPRX1 Gene

GeneCards Summary for MRGPRX1 Gene

MRGPRX1 (MAS Related GPR Family Member X1) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX3.

UniProtKB/Swiss-Prot for MRGPRX1 Gene

  • Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.

Gene Wiki entry for MRGPRX1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRX1 Gene

Genomics for MRGPRX1 Gene

Regulatory Elements for MRGPRX1 Gene

Enhancers for MRGPRX1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MRGPRX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRGPRX1 Gene

Chromosome:
11
Start:
18,933,813 bp from pter
End:
18,939,507 bp from pter
Size:
5,695 bases
Orientation:
Minus strand

Genomic View for MRGPRX1 Gene

Genes around MRGPRX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGPRX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGPRX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRX1 Gene

Proteins for MRGPRX1 Gene

  • Protein details for MRGPRX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LB2-MRGX1_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor member X1
    Protein Accession:
    Q96LB2
    Secondary Accessions:
    • Q4V9L2
    • Q8TDD8
    • Q8TDD9

    Protein attributes for MRGPRX1 Gene

    Size:
    322 amino acids
    Molecular mass:
    36250 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Activation of this receptor requires concentrations that exceed the chloroquine concentrations observed in plasma of patients undergoing chloroquine treatment. However, chloroquine accumulates at much higher level in the skin where the receptor is located. Chloroquine-induced itch is very common among black Africans (up to 70%) but less common in other populations.

neXtProt entry for MRGPRX1 Gene

Post-translational modifications for MRGPRX1 Gene

  • Glycosylation at Asn 16
  • Modification sites at PhosphoSitePlus

Other Protein References for MRGPRX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRGPRX1 Gene

Domains & Families for MRGPRX1 Gene

Gene Families for MRGPRX1 Gene

Protein Domains for MRGPRX1 Gene

Suggested Antigen Peptide Sequences for MRGPRX1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96LB2

UniProtKB/Swiss-Prot:

MRGX1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRX1: view

Function for MRGPRX1 Gene

Molecular function for MRGPRX1 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.

Gene Ontology (GO) - Molecular Function for MRGPRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
genes like me logo Genes that share ontologies with MRGPRX1: view
genes like me logo Genes that share phenotypes with MRGPRX1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MRGPRX1

CRISPR Products

miRNA for MRGPRX1 Gene

miRTarBase miRNAs that target MRGPRX1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRGPRX1 Gene

Localization for MRGPRX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRX1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRGPRX1 Gene COMPARTMENTS Subcellular localization image for MRGPRX1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for MRGPRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with MRGPRX1: view

Pathways & Interactions for MRGPRX1 Gene

SuperPathways for MRGPRX1 Gene

No Data Available

Interacting Proteins for MRGPRX1 Gene

Gene Ontology (GO) - Biological Process for MRGPRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006953 acute-phase response IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with MRGPRX1: view

No data available for Pathways by source and SIGNOR curated interactions for MRGPRX1 Gene

Drugs & Compounds for MRGPRX1 Gene

(5) Drugs for MRGPRX1 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
chloroquine Approved, Vet_approved Pharma Agonist, inhibitor 145
BAM (8-22) Pharma Selective agonist for the sensory neuron specific receptor (SNSR) 0
calcium Nutra 0
BAM 22P Pharma Potent endogenous agonist peptide for the newly identified sensory neuron specific receptor (SNSR); 0
BOVINE ADRENAL MEDULLA PEPTIDE 8-22 Pharma 0

(3) Additional Compounds for MRGPRX1 Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BAM8-22
Full agonist, Agonist
ML 382
1646499-97-9

(2) Tocris Compounds for MRGPRX1 Gene

Compound Action Cas Number
BAM (8-22) Selective agonist for the sensory neuron specific receptor (SNSR) 412961-36-5
ML 382 MrgX1 (SNSR4) positive allosteric modulator 1646499-97-9

(2) ApexBio Compounds for MRGPRX1 Gene

Compound Action Cas Number
BAM (8-22) 412961-36-5
BAM 22P Potent endogenous agonist peptide for the newly identified sensory neuron specific receptor (SNSR); 76622-26-9
genes like me logo Genes that share compounds with MRGPRX1: view

Transcripts for MRGPRX1 Gene

mRNA/cDNA for MRGPRX1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGPRX1 Gene

MAS-related GPR, member X1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRX1 Gene

No ASD Table

Relevant External Links for MRGPRX1 Gene

GeneLoc Exon Structure for
MRGPRX1
ECgene alternative splicing isoforms for
MRGPRX1

Expression for MRGPRX1 Gene

mRNA expression in normal human tissues for MRGPRX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of MRGPRX1 Gene:

MRGPRX1

SOURCE GeneReport for Unigene cluster for MRGPRX1 Gene:

Hs.711459

mRNA Expression by UniProt/SwissProt for MRGPRX1 Gene:

Q96LB2-MRGX1_HUMAN
Tissue specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
genes like me logo Genes that share expression patterns with MRGPRX1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MRGPRX1 Gene

Orthologs for MRGPRX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Mrgprb2 34
  • 64.08 (n)
  • 53.07 (a)
Mrgprb2 16
Mrgprb1 35
  • 44 (a)
ManyToMany
Mrgprb2 35
  • 48 (a)
ManyToMany
Mrgprb3 35
  • 44 (a)
ManyToMany
Mrgprb4 35
  • 47 (a)
ManyToMany
Mrgprb5 35
  • 46 (a)
ManyToMany
Mrgprb8 35
  • 40 (a)
ManyToMany
Mrgprx1 35
  • 53 (a)
ManyToMany
Mrgprx2 35
  • 47 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia MRGPRX1 34
  • 98.34 (n)
  • 95.96 (a)
MRGPRX1 35
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrgprb2 34
  • 63.91 (n)
  • 52.65 (a)
cow
(Bos Taurus)
Mammalia MRGPRX2 35
  • 55 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 37 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 35 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 32 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
Species where no ortholog for MRGPRX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRX1 Gene

ENSEMBL:
Gene Tree for MRGPRX1 (if available)
TreeFam:
Gene Tree for MRGPRX1 (if available)

Paralogs for MRGPRX1 Gene

Paralogs for MRGPRX1 Gene

(10) SIMAP similar genes for MRGPRX1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MRGPRX1 Gene

genes like me logo Genes that share paralogs with MRGPRX1: view

Variants for MRGPRX1 Gene

Sequence variations from dbSNP and Humsavar for MRGPRX1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11024885 - 18,934,679(+) AACGA(C/T)GCACG reference, missense
rs78179510 - 18,934,649(+) AACTG(C/T)GTTTC reference, missense
rs55954376 - 18,934,621(+) GCATG(A/C/T)GGCAG reference, missense
rs111448117 - 18,934,394(+) GCAGC(A/G/T)GTACC reference, missense
rs140351170 - 18,934,387(+) GGCGG(C/T)GGCAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MRGPRX1 Gene

Variant ID Type Subtype PubMed ID
dgv1061n100 CNV gain 25217958
dgv1062n100 CNV gain 25217958
dgv1063n100 CNV gain 25217958
dgv1064n100 CNV loss 25217958
dgv1065n100 CNV gain+loss 25217958
dgv1066n100 CNV loss 25217958
dgv1067n100 CNV gain 25217958
dgv1068n100 CNV gain+loss 25217958
dgv1069n100 CNV gain+loss 25217958
dgv1070n100 CNV gain 25217958
dgv1071n100 CNV gain 25217958
dgv1675n54 CNV loss 21841781
dgv1676n54 CNV loss 21841781
dgv1677n54 CNV loss 21841781
dgv1678n54 CNV loss 21841781
dgv1679n54 CNV gain 21841781
dgv1680n54 CNV gain+loss 21841781
dgv1681n54 CNV loss 21841781
dgv1682n54 CNV gain 21841781
dgv1683n54 CNV loss 21841781
dgv186e214 CNV gain 21293372
dgv19e203 CNV gain+loss 21179565
dgv328e212 CNV gain 25503493
dgv329e212 CNV loss 25503493
dgv330e212 CNV gain 25503493
dgv41e55 CNV gain 17911159
dgv42e55 CNV gain 17911159
dgv43e55 CNV gain 17911159
dgv44e55 CNV loss 17911159
dgv44n111 CNV duplication 26073780
dgv45e55 CNV gain 17911159
dgv45n111 CNV duplication 26073780
dgv46e55 CNV gain 17911159
dgv46n111 OTHER complex 26073780
dgv47n111 CNV duplication 26073780
esv2744173 CNV deletion 23290073
esv2744174 CNV deletion 23290073
esv2750987 CNV gain 17911159
esv2750988 CNV loss 17911159
esv2750990 CNV gain 17911159
esv2759806 CNV gain+loss 17122850
esv27702 CNV gain 19812545
esv33835 CNV loss 17666407
esv34069 CNV loss 18971310
esv3547395 CNV deletion 23714750
esv3578361 CNV gain 25503493
esv3579411 CNV loss 25503493
esv3584576 CNV gain 24956385
esv3584636 CNV loss 24956385
esv3625519 CNV loss 21293372
esv3891938 CNV loss 25118596
esv992072 CNV loss 20482838
nsv1036170 CNV loss 25217958
nsv1042071 CNV gain 25217958
nsv1046971 CNV loss 25217958
nsv1053939 CNV gain 25217958
nsv1054855 CNV gain 25217958
nsv1121472 CNV deletion 24896259
nsv1159837 CNV deletion 26073780
nsv428250 CNV gain 18775914
nsv436822 CNV insertion 17901297
nsv442602 CNV gain+loss 18776908
nsv509394 CNV insertion 20534489
nsv514600 CNV gain+loss 21397061
nsv526229 CNV gain 19592680
nsv553633 CNV gain 21841781
nsv553635 CNV gain 21841781
nsv553654 CNV gain 21841781
nsv553666 CNV loss 21841781
nsv553673 CNV gain+loss 21841781
nsv553675 CNV loss 21841781
nsv7697 CNV deletion 18451855
nsv820227 CNV gain 19587683
nsv821368 CNV deletion 20802225
nsv825776 CNV loss 20364138
nsv825777 CNV gain 20364138
nsv825778 CNV gain 20364138
nsv832080 CNV gain 17160897
nsv832082 CNV gain 17160897
nsv8795 CNV gain 18304495
nsv951318 CNV duplication 24416366
nsv975889 CNV duplication 23825009

Variation tolerance for MRGPRX1 Gene

Residual Variation Intolerance Score: 63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRGPRX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRGPRX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRGPRX1 Gene

Disorders for MRGPRX1 Gene

Relevant External Links for MRGPRX1

Genetic Association Database (GAD)
MRGPRX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRGPRX1

No disorders were found for MRGPRX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGPRX1 Gene

Publications for MRGPRX1 Gene

  1. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PMID: 11551509) Dong X. … Anderson D.J. (Cell 2001) 2 3 4 65
  2. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. (PMID: 20004959) Liu Q. … Dong X. (Cell 2009) 4 22 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. (PMID: 11850634) Lembo P.M.C. … Ahmad S. (Nat. Neurosci. 2002) 3 4 65
  5. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4 65

Products for MRGPRX1 Gene

Sources for MRGPRX1 Gene

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