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Aliases for MRGPRX1 Gene

Aliases for MRGPRX1 Gene

  • MAS Related GPR Family Member X1 2 3 5
  • Sensory Neuron-Specific G-Protein Coupled Receptor 3/4 3 4
  • MAS-Related GPR, Member X1 2 3
  • MRGX1 3 4
  • SNSR4 3 4
  • Mas-Related G Protein-Coupled Receptor G2 3
  • G Protein-Coupled Receptor MRGX1 3
  • G Protein-Coupled Receptor SNSR3 3
  • MGRG2 3
  • SNSR3 4
  • GPCR 3

External Ids for MRGPRX1 Gene

Previous GeneCards Identifiers for MRGPRX1 Gene

  • GC11M018912
  • GC11M018886
  • GC11M018639

Summaries for MRGPRX1 Gene

GeneCards Summary for MRGPRX1 Gene

MRGPRX1 (MAS Related GPR Family Member X1) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX4.

UniProtKB/Swiss-Prot for MRGPRX1 Gene

  • Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.

Gene Wiki entry for MRGPRX1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRX1 Gene

Genomics for MRGPRX1 Gene

Regulatory Elements for MRGPRX1 Gene

Genomic Location for MRGPRX1 Gene

Chromosome:
11
Start:
18,933,813 bp from pter
End:
18,939,507 bp from pter
Size:
5,695 bases
Orientation:
Minus strand

Genomic View for MRGPRX1 Gene

Genes around MRGPRX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGPRX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGPRX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRX1 Gene

Proteins for MRGPRX1 Gene

  • Protein details for MRGPRX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LB2-MRGX1_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor member X1
    Protein Accession:
    Q96LB2
    Secondary Accessions:
    • Q4V9L2
    • Q8TDD8
    • Q8TDD9

    Protein attributes for MRGPRX1 Gene

    Size:
    322 amino acids
    Molecular mass:
    36250 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Activation of this receptor requires concentrations that exceed the chloroquine concentrations observed in plasma of patients undergoing chloroquine treatment. However, chloroquine accumulates at much higher level in the skin where the receptor is located. Chloroquine-induced itch is very common among black Africans (up to 70%) but less common in other populations.

neXtProt entry for MRGPRX1 Gene

Proteomics data for MRGPRX1 Gene at MOPED

Post-translational modifications for MRGPRX1 Gene

  • Glycosylation at Asn 16
  • Modification sites at PhosphoSitePlus

Other Protein References for MRGPRX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MRGPRX1 Gene

Domains & Families for MRGPRX1 Gene

Gene Families for MRGPRX1 Gene

Protein Domains for MRGPRX1 Gene

Suggested Antigen Peptide Sequences for MRGPRX1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96LB2

UniProtKB/Swiss-Prot:

MRGX1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRX1: view

Function for MRGPRX1 Gene

Molecular function for MRGPRX1 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.
genes like me logo Genes that share phenotypes with MRGPRX1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MRGPRX1

CRISPR Products

miRNA for MRGPRX1 Gene

miRTarBase miRNAs that target MRGPRX1

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRGPRX1 Gene

Localization for MRGPRX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRX1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRGPRX1 Gene COMPARTMENTS Subcellular localization image for MRGPRX1 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for MRGPRX1 Gene

Pathways & Interactions for MRGPRX1 Gene

SuperPathways for MRGPRX1 Gene

No Data Available

Interacting Proteins for MRGPRX1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000305766%0d%0a9606.ENSP00000367869%0d%0a9606.ENSP00000334448%0d%0a9606.ENSP00000286548%0d%0a
Selected Interacting proteins: ENSP00000305766 for MRGPRX1 Gene via STRING

Gene Ontology (GO) - Biological Process for MRGPRX1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MRGPRX1 Gene

Drugs & Compounds for MRGPRX1 Gene

(3) Drugs for MRGPRX1 Gene - From: DGIdb, Novoseek, HMDB, and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
chloroquine Approved Pharma Agonist, inhibitor 141
calcium Nutra 0
BOVINE ADRENAL MEDULLA PEPTIDE 8-22 Pharma 0

(4) Additional Compounds for MRGPRX1 Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BAM8-22
Full agonist, Agonist
BAM (8-22)
412961-36-5
BAM 22P
76622-26-9
genes like me logo Genes that share compounds with MRGPRX1: view

Transcripts for MRGPRX1 Gene

mRNA/cDNA for MRGPRX1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGPRX1 Gene

MAS-related GPR, member X1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRX1 Gene

No ASD Table

Relevant External Links for MRGPRX1 Gene

GeneLoc Exon Structure for
MRGPRX1
ECgene alternative splicing isoforms for
MRGPRX1

Expression for MRGPRX1 Gene

mRNA expression in normal human tissues for MRGPRX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for MRGPRX1 Gene Hs.711459

mRNA Expression by UniProt/SwissProt for MRGPRX1 Gene

Q96LB2-MRGX1_HUMAN
Tissue specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
genes like me logo Genes that share expression patterns with MRGPRX1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MRGPRX1 Gene

Orthologs for MRGPRX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Mrgprb2 35
  • 64.08 (n)
  • 53.07 (a)
Mrgprb2 16
Mrgprb1 36
  • 44 (a)
ManyToMany
Mrgprb2 36
  • 48 (a)
ManyToMany
Mrgprb3 36
  • 44 (a)
ManyToMany
Mrgprb4 36
  • 47 (a)
ManyToMany
Mrgprb5 36
  • 46 (a)
ManyToMany
Mrgprb8 36
  • 40 (a)
ManyToMany
Mrgprx1 36
  • 53 (a)
ManyToMany
Mrgprx2 36
  • 47 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia MRGPRX1 35
  • 98.34 (n)
  • 95.96 (a)
MRGPRX1 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrgprb2 35
  • 63.91 (n)
  • 52.65 (a)
cow
(Bos Taurus)
Mammalia MRGPRX2 36
  • 55 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
Species with no ortholog for MRGPRX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRX1 Gene

ENSEMBL:
Gene Tree for MRGPRX1 (if available)
TreeFam:
Gene Tree for MRGPRX1 (if available)

Paralogs for MRGPRX1 Gene

Paralogs for MRGPRX1 Gene

(10) SIMAP similar genes for MRGPRX1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MRGPRX1 Gene

genes like me logo Genes that share paralogs with MRGPRX1: view

Variants for MRGPRX1 Gene

Sequence variations from dbSNP and Humsavar for MRGPRX1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11024885 - 18,934,679(+) AACGA(C/T)GCACG reference, missense
VAR_075462 -
VAR_075463 -
VAR_075464 -
VAR_075465 -

Structural Variations from Database of Genomic Variants (DGV) for MRGPRX1 Gene

Variant ID Type Subtype PubMed ID
dgv347e1 CNV Complex 17122850
nsv428250 CNV Gain 18775914
nsv832080 CNV Gain 17160897
esv2750987 CNV Gain 17911159
nsv832082 CNV Gain 17160897
esv2750988 CNV Loss 17911159
dgv41e55 CNV Gain 17911159
esv27702 CNV Gain 19812545
esv2750990 CNV Gain 17911159
nsv7697 CNV Loss 18451855
esv2744173 CNV Deletion 23290073
dgv348e1 CNV Complex 17122850
esv33835 CNV Loss 17666407
dgv42e55 CNV Gain 17911159
nsv526229 CNV Gain 19592680
esv34069 CNV Loss 18971310
dgv349e1 CNV Complex 17122850
dgv43e55 CNV Gain 17911159
nsv825776 CNV Loss 20364138
nsv897029 CNV Gain+Loss 21882294
nsv825777 CNV Gain 20364138
nsv8795 CNV Gain 18304495
esv2744174 CNV Deletion 23290073
esv992072 CNV Loss 20482838
nsv820227 CNV Gain 19587683
nsv436822 CNV Insertion 17901297
nsv509394 CNV Insertion 20534489
nsv442602 CNV CNV 18776908
nsv821368 CNV Deletion 20802225
dgv350e1 CNV Complex 17122850
dgv44e55 CNV Loss 17911159
dgv45e55 CNV Gain 17911159
dgv351e1 CNV Complex 17122850
dgv46e55 CNV Gain 17911159
nsv825778 CNV Gain 20364138
nsv514600 CNV Complex 21397061

Variation tolerance for MRGPRX1 Gene

Residual Variation Intolerance Score: 63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRGPRX1 Gene

HapMap Linkage Disequilibrium report
MRGPRX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRGPRX1 Gene

Disorders for MRGPRX1 Gene

Relevant External Links for MRGPRX1

Genetic Association Database (GAD)
MRGPRX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRGPRX1

No disorders were found for MRGPRX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGPRX1 Gene

Publications for MRGPRX1 Gene

  1. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PMID: 11551509) Dong X. … Anderson D.J. (Cell 2001) 2 3 4 67
  2. Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes. (PMID: 24583173) Premzl M. (Gene 2014) 3
  3. Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways. (PMID: 23074220) Solinski H.J. … Breit A. (J. Biol. Chem. 2012) 3
  4. Increasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery? (PMID: 19465029) Filizola M. (Life Sci. 2010) 23
  5. Synthesis and characterization of a cellular membrane affinity chromatography column containing histamine 1 and P2Y(1) receptors: a multiple G-protein coupled receptor column. (PMID: 19608372) Moaddel R. … Wainer I.W. (J Pharm Biomed Anal 2010) 23

Products for MRGPRX1 Gene

Sources for MRGPRX1 Gene

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