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Aliases for MRGPRX1 Gene

Aliases for MRGPRX1 Gene

  • MAS-Related GPR, Member X1 2 3
  • MRGX1 3 4 6
  • Sensory Neuron-Specific G-Protein Coupled Receptor 3/4 3 4
  • SNSR4 3 4
  • Mas-Related G-Protein Coupled Receptor Member X1 3
  • Mas-Related G Protein-Coupled Receptor G2 3
  • G Protein-Coupled Receptor MRGX1 3
  • G Protein-Coupled Receptor SNSR3 3
  • MGRG2 3
  • SNSR3 4
  • GPCR 3

External Ids for MRGPRX1 Gene

Summaries for MRGPRX1 Gene

GeneCards Summary for MRGPRX1 Gene

MRGPRX1 (MAS-Related GPR, Member X1) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX4.

UniProtKB/Swiss-Prot for MRGPRX1 Gene

  • Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.

Gene Wiki entry for MRGPRX1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRX1 Gene

Genomics for MRGPRX1 Gene

Genomic Location for MRGPRX1 Gene

Start:
18,933,813 bp from pter
End:
18,939,507 bp from pter
Size:
5,695 bases
Orientation:
Minus strand

Genomic View for MRGPRX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRGPRX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRX1 Gene

Regulatory Elements for MRGPRX1 Gene

Proteins for MRGPRX1 Gene

  • Protein details for MRGPRX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LB2-MRGX1_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor member X1
    Protein Accession:
    Q96LB2
    Secondary Accessions:
    • Q4V9L2
    • Q8TDD8
    • Q8TDD9

    Protein attributes for MRGPRX1 Gene

    Size:
    322 amino acids
    Molecular mass:
    36250 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Activation of this receptor requires concentrations that exceed the chloroquine concentrations observed in plasma of patients undergoing chloroquine treatment. However, chloroquine accumulates at much higher level in the skin where the receptor is located. Chloroquine-induced itch is very common among black Africans (up to 70%) but less common in other populations

neXtProt entry for MRGPRX1 Gene

Proteomics data for MRGPRX1 Gene at MOPED

Post-translational modifications for MRGPRX1 Gene

Other Protein References for MRGPRX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRGPRX1 Gene

Domains for MRGPRX1 Gene

Gene Families for MRGPRX1 Gene

HGNC:
  • GPCRAO :GPCR / Class A : Orphans
IUPHAR :

Protein Domains for MRGPRX1 Gene

UniProtKB/Swiss-Prot:

MRGX1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.:
    • Q96LB2
genes like me logo Genes that share domains with MRGPRX1: view

Function for MRGPRX1 Gene

Molecular function for MRGPRX1 Gene

UniProtKB/Swiss-Prot Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.

Gene Ontology (GO) - Molecular Function for MRGPRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with MRGPRX1: view

Phenotypes for MRGPRX1 Gene

genes like me logo Genes that share phenotypes with MRGPRX1: view

miRNA for MRGPRX1 Gene

miRTarBase miRNAs that target MRGPRX1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRGPRX1 Gene

Localization for MRGPRX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRX1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRGPRX1 Gene COMPARTMENTS Subcellular localization image for MRGPRX1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for MRGPRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MRGPRX1: view

Pathways for MRGPRX1 Gene

SuperPathways for MRGPRX1 Gene

No Data Available

Interacting Proteins for MRGPRX1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000305766%0d%0a9606.ENSP00000286548%0d%0a9606.ENSP00000367869%0d%0a9606.ENSP00000334448%0d%0a
Selected Interacting proteins: ENSP00000305766 for MRGPRX1 Gene via STRING

Gene Ontology (GO) - Biological Process for MRGPRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006953 acute-phase response IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with MRGPRX1: view

No data available for Pathways by source for MRGPRX1 Gene

Compounds for MRGPRX1 Gene

(1) HMDB Compounds for MRGPRX1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(2) IUPHAR Ligand for MRGPRX1 Gene

Ligand Type Action Affinity Pubmed IDs
BAM8-22 Agonist Full agonist 7.68
chloroquine Agonist Agonist 3.53

(2) Novoseek inferred chemical compound relationships for MRGPRX1 Gene

Compound -log(P) Hits PubMed IDs
calcium 11.8 1
gnrh 1.27 1
genes like me logo Genes that share compounds with MRGPRX1: view

Transcripts for MRGPRX1 Gene

mRNA/cDNA for MRGPRX1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGPRX1 Gene

MAS-related GPR, member X1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRX1 Gene

No ASD Table

Relevant External Links for MRGPRX1 Gene

GeneLoc Exon Structure for
MRGPRX1
ECgene alternative splicing isoforms for
MRGPRX1

Expression for MRGPRX1 Gene

mRNA expression in normal human tissues for MRGPRX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for MRGPRX1 Gene Hs.711459

mRNA Expression by UniProt/SwissProt for MRGPRX1 Gene

Q96LB2-MRGX1_HUMAN
Tissue specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
genes like me logo Genes that share expressions with MRGPRX1: view

Orthologs for MRGPRX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRGPRX1 36
  • 98.34 (n)
  • 95.96 (a)
MRGPRX1 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRGPRX2 37
  • 55 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 55 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mrgprb1 37
  • 44 (a)
ManyToMany
Mrgprb2 36
  • 64.08 (n)
  • 53.07 (a)
Mrgprb2 16
Mrgprb2 37
  • 48 (a)
ManyToMany
Mrgprb3 37
  • 44 (a)
ManyToMany
Mrgprb4 37
  • 47 (a)
ManyToMany
Mrgprb5 37
  • 46 (a)
ManyToMany
Mrgprb8 37
  • 40 (a)
ManyToMany
Mrgprx1 37
  • 53 (a)
ManyToMany
Mrgprx2 37
  • 47 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 37 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 35 (a)
ManyToMany
-- 37
  • 37 (a)
ManyToMany
-- 37
  • 35 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Mrgprb2 36
  • 63.91 (n)
  • 52.65 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 32 (a)
ManyToMany
-- 37
  • 33 (a)
ManyToMany
-- 37
  • 36 (a)
ManyToMany
-- 37
  • 33 (a)
ManyToMany
-- 37
  • 31 (a)
ManyToMany
-- 37
  • 29 (a)
ManyToMany
-- 37
  • 32 (a)
ManyToMany
-- 37
  • 29 (a)
ManyToMany
-- 37
  • 32 (a)
ManyToMany
-- 37
  • 23 (a)
ManyToMany
-- 37
  • 28 (a)
ManyToMany
-- 37
  • 27 (a)
ManyToMany
-- 37
  • 29 (a)
ManyToMany
-- 37
  • 25 (a)
ManyToMany
-- 37
  • 24 (a)
ManyToMany
-- 37
  • 28 (a)
ManyToMany
Species with no ortholog for MRGPRX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRX1 Gene

ENSEMBL:
Gene Tree for MRGPRX1 (if available)
TreeFam:
Gene Tree for MRGPRX1 (if available)

Paralogs for MRGPRX1 Gene

Paralogs for MRGPRX1 Gene

Selected SIMAP similar genes for MRGPRX1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MRGPRX1 Gene

genes like me logo Genes that share paralogs with MRGPRX1: view

Variants for MRGPRX1 Gene

Sequence variations from dbSNP and Humsavar for MRGPRX1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1384650 -- 18,935,763(+) TAATT(A/G)AAGTG upstream-variant-2KB
rs1842914 -- 18,935,650(+) AGAAG(A/C)ATTTT upstream-variant-2KB
rs1872021 -- 18,936,339(+) AGAGA(A/G)AGAGA upstream-variant-2KB
rs2004383 -- 18,935,031(+) GTGCT(A/G)ACATG upstream-variant-2KB
rs2004384 -- 18,935,143(+) TTCAG(A/G)TATGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRGPRX1 Gene

Variant ID Type Subtype PubMed ID
dgv347e1 CNV Complex 17122850
nsv428250 CNV Gain 18775914
nsv832080 CNV Gain 17160897
esv2750987 CNV Gain 17911159
nsv832082 CNV Gain 17160897
esv2750988 CNV Loss 17911159
dgv41e55 CNV Gain 17911159
esv27702 CNV Gain 19812545
esv2750990 CNV Gain 17911159
nsv7697 CNV Loss 18451855
esv2744173 CNV Deletion 23290073
dgv348e1 CNV Complex 17122850
esv33835 CNV Loss 17666407
dgv42e55 CNV Gain 17911159
nsv526229 CNV Gain 19592680
esv34069 CNV Loss 18971310
dgv349e1 CNV Complex 17122850
dgv43e55 CNV Gain 17911159
nsv825776 CNV Loss 20364138
nsv897029 CNV Gain+Loss 21882294
nsv825777 CNV Gain 20364138
nsv8795 CNV Gain 18304495
esv2744174 CNV Deletion 23290073
esv992072 CNV Loss 20482838
nsv820227 CNV Gain 19587683
nsv436822 CNV Insertion 17901297
nsv509394 CNV Insertion 20534489
nsv442602 CNV CNV 18776908
nsv821368 CNV Deletion 20802225
dgv350e1 CNV Complex 17122850
dgv44e55 CNV Loss 17911159
dgv45e55 CNV Gain 17911159
dgv351e1 CNV Complex 17122850
dgv46e55 CNV Gain 17911159
nsv825778 CNV Gain 20364138
nsv514600 CNV Complex 21397061

Relevant External Links for MRGPRX1 Gene

HapMap Linkage Disequilibrium report
MRGPRX1

Disorders for MRGPRX1 Gene

(2) Novoseek inferred disease relationships for MRGPRX1 Gene

Disease -log(P) Hits PubMed IDs
cancer 5.62 1
sepsis 0 1

Relevant External Links for MRGPRX1

Genetic Association Database (GAD)
MRGPRX1
genes like me logo Genes that share disorders with MRGPRX1: view

No data available for UniProtKB/Swiss-Prot for MRGPRX1 Gene

Publications for MRGPRX1 Gene

  1. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PMID: 11551509) Dong X. … Anderson D.J. (Cell 2001) 2 3 4
  2. Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. (PMID: 11850634) Lembo P.M.C. … Ahmad S. (Nat. Neurosci. 2002) 3 4
  3. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4
  4. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. (PMID: 20004959) Liu Q. … Dong X. (Cell 2009) 4 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MRGPRX1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MRGPRX1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MRGPRX1
    • Block miRNA regulation of MRGPRX1 using miScript Target Protectors
    • antibodies-online peptides for MRGPRX1
    • antibodies-online antibodies for MRGPRX1
    • antibodies-online kits for MRGPRX1

    Sources for MRGPRX1 Gene

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