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MRGPRG Gene

protein-coding   GIFtS: 33
GCID: GC11M003243

MAS-Related GPR, Member G

(Previous name: G protein-coupled receptor 169)
(Previous symbol: GPR169)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MAS-Related GPR, Member G1 2     G Protein-Coupled Receptor MRGG2
GPR1691 2 3     Mas-Related G-Protein Coupled Receptor Member G2
MRGG2 3 5     G-Protein Coupled Receptor 1693
G Protein-Coupled Receptor 1691 2     

External Ids:    HGNC: 248291   Entrez Gene: 3867462   Ensembl: ENSG000001821707   OMIM: 6072345   UniProtKB: Q86SM53   

Export aliases for MRGPRG gene to outside databases

Previous GC identifers: GC11U900565 GC11M003195 GC11M003029


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MRGPRG Gene:
MRGPRG (MAS-related GPR, member G) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX3.

UniProtKB/Swiss-Prot: MRGRG_HUMAN, Q86SM5
Function: Orphan receptor. May regulate nociceptor function and/or development, including the sensation or
modulation of pain (By similarity)

Gene Wiki entry for MRGPRG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MRGPRG gene promoter:
         AhR   MyoD   Tal-1beta   NF-kappaB   Arnt   NF-kappaB2   SEF-1 (1)   NF-kappaB1   LyF-1   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRGPRG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

MRGPRG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRGPRG gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M003243:  view genomic region     (about GC identifiers)

Start:
3,239,174 bp from pter      End:
3,240,043 bp from pter
Size:
870 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MRGRG_HUMAN, Q86SM5 (See protein sequence)
Recommended Name: Mas-related G-protein coupled receptor member G  
Size: 289 amino acids; 31518 Da

Explore the universe of human proteins at neXtProt for MRGPRG: NX_Q86SM5

Explore proteomics data for MRGPRG at MOPED


See MRGPRG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001157849.1  
ENSEMBL proteins: 
 ENSP00000330612  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
GPCRAO: GPCR / Class A : Orphans

IUPHAR Guide to PHARMACOLOGY protein family classification: MRGPRG
Class A Orphans

4 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR027336 MRGPCRG
 IPR026234 MRGPCRFAMILY
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q86SM5

ProtoNet protein and cluster: Q86SM5

UniProtKB/Swiss-Prot: MRGRG_HUMAN, Q86SM5
Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily


Find genes that share domains with MRGPRG           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MRGRG_HUMAN, Q86SM5
Function: Orphan receptor. May regulate nociceptor function and/or development, including the sensation or
modulation of pain (By similarity)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
     
Find genes that share ontologies with MRGPRG           About GenesLikeMe


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MRGRG_HUMAN, Q86SM5: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with MRGPRG           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Array including MRGPRG: 
          G Protein Coupled Receptors 384HT in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for MRGPRG

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

Find genes that share ontologies with MRGPRG           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MRGPRG gene: 
NM_001164377.1  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000332314(uc001lxp.2)
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MRGPRG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MRGPRG Expression
About this image

MRGPRG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MRGPRG Protein Expression
    Pathway & Disease-focused RT2 Profiler PCR Array including MRGPRG: 
          G Protein Coupled Receptors 384HT in human mouse rat

Primer
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MRGPRG gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mrgprg1 , 5 MAS-related GPR, member G1, 5 69.36(n)1
57.89(a)1
  7 (88.31 cM)5
3819741  NM_203492.21  NP_987077.11 
 1437637115 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
21(a)
1 → many
JH376180.1(56001-57008) ENSGALG00000022324
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 16)
Uncharacterized protein
(see all 16)
27(a)
27(a)
(see all 16)
many ↔ many
many ↔ many
(see all 16)
4(16394563-16395360)
4(16472577-16473407)


ENSEMBL Gene Tree for MRGPRG (if available)
TreeFam Gene Tree for MRGPRG (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MRGPRG gene
MRGPRX32  MRGPRD2  MAS12  MAS1L2  MRGPRF2  MRGPRX42  MRGPRX12  MRGPRE2  
MRGPRX22  
7 SIMAP similar genes for MRGPRG using alignment to 1 protein entry:     MRGRG_HUMAN:
MRGPRD    MRGPRX2    MRGPRX3    MRGPRE    MRGPRX1    MRGPRX4
MRGPRF

Find genes that share paralogs with MRGPRG           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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1 SNPs for MRGPRG    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs125772221,2
C,F,A,H--3175283(+) CTCACC/ATGGGG 1 -- us2k1 tfbs36Minor allele frequency- A:0.16NA WA CSA EA 364

HapMap Linkage Disequilibrium report for MRGPRG (3239174 - 3240043 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for MRGPRG (see all 13):    About this table    
Variant IDTypeSubtypePubMed ID
esv992308CNV Deletion20482838
esv2678047CNV Deletion23128226
esv2744033CNV Deletion23290073
nsv524468CNV Loss19592680
nsv469931CNV Loss18288195
dgv1015n71CNV Loss21882294
esv27427CNV Loss19812545
nsv7649CNV Loss18451855
dgv19e180CNV Loss20482838
nsv428245CNV Gain18775914

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607234    OMIM disorders: --


Find genes that share disorders with MRGPRG           About GenesLikeMe


Export disorders for MRGPRG gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MRGPRG gene integrated from 10 sources:
(articles sorted by number of sources associating them with MRGPRG)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The G protein-coupled receptor repertoires of human and mouse. (PubMed id 12679517)1, 2, 3 Vassilatis D.K.... Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
  2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 386746 HGNC: 24829 Ensembl:ENSG00000182170 euGenes: HUgn386746 ECgene: MRGPRG
H-InvDB: MRGPRG

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MRGPRG Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MRGPRG gene:
Search GeneIP for patents involving MRGPRG

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      MRGPRG gene at Home site.
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