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Aliases for MRGPRG Gene

Aliases for MRGPRG Gene

  • MAS Related GPR Family Member G 2 3 5
  • G Protein-Coupled Receptor 169 2 3
  • MAS-Related GPR, Member G 2 3
  • GPR169 3 4
  • MRGG 3 4
  • Mas-Related G-Protein Coupled Receptor Member G 3
  • G Protein-Coupled Receptor MRGG 3
  • G-Protein Coupled Receptor 169 4

External Ids for MRGPRG Gene

Previous HGNC Symbols for MRGPRG Gene

  • GPR169

Previous GeneCards Identifiers for MRGPRG Gene

  • GC11U900565
  • GC11M003195
  • GC11M003029

Summaries for MRGPRG Gene

GeneCards Summary for MRGPRG Gene

MRGPRG (MAS Related GPR Family Member G) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRE.

UniProtKB/Swiss-Prot for MRGPRG Gene

  • Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).

Gene Wiki entry for MRGPRG Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRG Gene

Genomics for MRGPRG Gene

Regulatory Elements for MRGPRG Gene

Enhancers for MRGPRG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MRGPRG on UCSC Golden Path with GeneCards custom track

Genomic Location for MRGPRG Gene

Chromosome:
11
Start:
3,217,944 bp from pter
End:
3,218,813 bp from pter
Size:
870 bases
Orientation:
Minus strand

Genomic View for MRGPRG Gene

Genes around MRGPRG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGPRG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGPRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRG Gene

Proteins for MRGPRG Gene

  • Protein details for MRGPRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SM5-MRGRG_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor member G
    Protein Accession:
    Q86SM5

    Protein attributes for MRGPRG Gene

    Size:
    289 amino acids
    Molecular mass:
    31518 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRGPRG Gene

Post-translational modifications for MRGPRG Gene

No Post-translational modifications

Other Protein References for MRGPRG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRGPRG Gene

Domains & Families for MRGPRG Gene

Gene Families for MRGPRG Gene

Protein Domains for MRGPRG Gene

Suggested Antigen Peptide Sequences for MRGPRG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86SM5

UniProtKB/Swiss-Prot:

MRGRG_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRG: view

Function for MRGPRG Gene

Molecular function for MRGPRG Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).

Gene Ontology (GO) - Molecular Function for MRGPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
genes like me logo Genes that share ontologies with MRGPRG: view

Phenotypes for MRGPRG Gene

GenomeRNAi human phenotypes for MRGPRG:
genes like me logo Genes that share phenotypes with MRGPRG: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MRGPRG

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRGPRG Gene

Localization for MRGPRG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRG Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRGPRG Gene COMPARTMENTS Subcellular localization image for MRGPRG gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for MRGPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with MRGPRG: view

Pathways & Interactions for MRGPRG Gene

SuperPathways for MRGPRG Gene

No Data Available

Interacting Proteins for MRGPRG Gene

Gene Ontology (GO) - Biological Process for MRGPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with MRGPRG: view

No data available for Pathways by source and SIGNOR curated interactions for MRGPRG Gene

Drugs & Compounds for MRGPRG Gene

No Compound Related Data Available

Transcripts for MRGPRG Gene

mRNA/cDNA for MRGPRG Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRG Gene

No ASD Table

Relevant External Links for MRGPRG Gene

GeneLoc Exon Structure for
MRGPRG
ECgene alternative splicing isoforms for
MRGPRG

Expression for MRGPRG Gene

mRNA expression in normal human tissues for MRGPRG Gene

mRNA differential expression in normal tissues according to GTEx for MRGPRG Gene

This gene is overexpressed in Testis (x42.9) and Cervix - Endocervix (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of MRGPRG Gene:

MRGPRG

SOURCE GeneReport for Unigene cluster for MRGPRG Gene:

Hs.730306
genes like me logo Genes that share expression patterns with MRGPRG: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MRGPRG Gene

Orthologs for MRGPRG Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC618771 34
  • 77.82 (n)
  • 66.55 (a)
MRGPRG 35
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRGPRG 34
  • 78.55 (n)
  • 67.48 (a)
MRGPRG 35
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrgprg 34
  • 69.36 (n)
  • 57.89 (a)
Mrgprg 16
Mrgprg 35
  • 57 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRGPRG 34
  • 98.15 (n)
  • 96.87 (a)
MRGPRG 35
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrgprg 34
  • 69.11 (n)
  • 57.69 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 36 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 30 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 21 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 22 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 17 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
-- 35
  • 19 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
Species where no ortholog for MRGPRG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRG Gene

ENSEMBL:
Gene Tree for MRGPRG (if available)
TreeFam:
Gene Tree for MRGPRG (if available)

Paralogs for MRGPRG Gene

Paralogs for MRGPRG Gene

(7) SIMAP similar genes for MRGPRG Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MRGPRG: view

Variants for MRGPRG Gene

Structural Variations from Database of Genomic Variants (DGV) for MRGPRG Gene

Variant ID Type Subtype PubMed ID
dgv176e214 CNV gain 21293372
dgv19e180 CNV loss 20482838
dgv574n106 CNV deletion 24896259
esv2678047 CNV deletion 23128226
esv27427 CNV loss 19812545
esv2744033 CNV deletion 23290073
esv2759796 CNV gain+loss 17122850
esv3259052 CNV deletion 24192839
esv3547230 CNV deletion 23714750
esv3625135 CNV loss 21293372
esv992308 CNV deletion 20482838
nsv428245 CNV gain 18775914
nsv469931 CNV loss 18288195
nsv524468 CNV loss 19592680
nsv7649 CNV deletion 18451855
nsv951295 CNV deletion 24416366

Variation tolerance for MRGPRG Gene

Gene Damage Index Score: 3.57; 56.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for MRGPRG Gene

Disorders for MRGPRG Gene

Relevant External Links for MRGPRG

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRGPRG

No disorders were found for MRGPRG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGPRG Gene

Publications for MRGPRG Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 65
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 65

Products for MRGPRG Gene

Sources for MRGPRG Gene

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