MRGPRG Gene
protein-coding GIFtS: 32
GCID: GC11M003195
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MAS-related GPR, member G(Previous name: G protein-coupled receptor 169 )
(Previous symbol: GPR169)
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Aliases
for MRGPRG gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MAS-Related GPR, Member G1 2 | | MrgG1 | | GPR1691 2 3 | | G Protein-Coupled Receptor MRGG2 | | MRGG2 3 5 | | Mas-Related G-Protein Coupled Receptor Member G2 | | G Protein-Coupled Receptor 1691 2 | | G-Protein Coupled Receptor 1693 |
Export aliases for MRGPRG gene to outside databasesPrevious GC identifers: GC11U900565 GC11M003029 |
Summaries
for MRGPRG gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MRGRG_HUMAN, Q86SM5Function: Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulationof pain (By similarity)
Gene Wiki entry for MRGPRG
|
Genomic Views
for MRGPRG gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRGPRG gene promoter:
AhR MyoD Tal-1beta NF-kappaB Arnt NF-kappaB2 SEF-1 (1) NF-kappaB1 LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRGPRG
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRGPRG |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4MRGPRG Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M003195: view genomic region
(about GC identifiers)
Start:
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3,239,174 bp from pter |
End:
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3,240,043 bp from pter |
Size:
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870 bases |
Orientation:
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minus strand |
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Proteins
for MRGPRG gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MRGRG_HUMAN, Q86SM5 (See
protein sequence)Recommended Name: Mas-related G-protein coupled receptor member G Size: 289 amino acids; 31518 Da
Subcellular location: Cell membrane; Multi-pass membrane proteinExplore the universe of human proteins at neXtProt for MRGPRG: NX_Q86SM5
MRGPRG Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001157849.1
ENSEMBL proteins: ENSP00000330612
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
MRGPRG for ontologies About GeneDecksing
MRGPRG Antibody Products:
Assay Products for MRGPRG: |
Protein
Domains /
Families
for MRGPRG gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRGPRG for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86SM5ProtoNet protein and cluster: Q86SM5 UniProtKB/Swiss-Prot: MRGRG_HUMAN, Q86SM5Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily |
Function
for MRGPRG gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MRGRG_HUMAN, Q86SM5Function: Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulationof pain (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRG (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRG
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRGPRG (NM_001164377) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRGPRG | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MRGPRG |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- |
MRGPRG for ontologies About GeneDecksing
|
Pathways & Interactions
for MRGPRG gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRGPRG
|
Drugs & Compounds
for MRGPRG gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRGPRG
Search CenterWatch for drugs/clinical trials and news about MRGPRG / MRGRG
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Transcripts
for MRGPRG gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRGPRG gene: NM_001164377.1 Unigene Cluster for MRGPRG: MAS-related GPR, member G Hs.730306 Unigene Representative Sequence: NM_0011643771 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000332314(uc001lxp.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRG (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRG
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRGPRG (NM_001164377) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRGPRG | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MRGPRG |
Additional cDNA sequence: AY255583.1
GeneLoc Exon Structure
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Expression
for MRGPRG gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRGPRG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MRGPRG Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.730306
SABiosciences Expression via Pathway-Focused PCR Array including MRGPRG:
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRGPRG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRGPRG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRGPRG |
Orthologs
for MRGPRG gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MRGPRG gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for MRGPRG (if available)
TreeFam Gene Tree for MRGPRG (if available) |
Paralogs
for MRGPRG gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRGPRG gene
- MRGPRX32 MRGPRX12 MRGPRD2 MRGPRE2 MRGPRX22 MAS12 MAS1L2 MRGPRF2
- MRGPRX42
7 SIMAP similar genes for MRGPRG using alignment to 1 protein entry: MRGRG_HUMAN:MRGPRD MRGPRX2 MRGPRX3 MRGPRE MRGPRX1 MRGPRX4
MRGPRF
MRGPRG for paralogs About GeneDecksing
|
Genomic Variants
for MRGPRG gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MRGPRG
2 CNVs: 3833 65842 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRGPRG |
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Disorders
/ Diseases
for MRGPRG gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRGPRG for disorders About MalaCards
MRGPRG for disorders About GeneDecksing
OMIM gene information: 607234
OMIM disorders: --
Export disorders for MRGPRG gene to outside databases
|
Publications
for MRGPRG gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRGPRG gene integrated from 9 sources:
(articles sorted by number of sources associating them with MRGPRG) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The G protein-coupled receptor repertoires of human and mouse. (PubMed id 12679517)1, 2, 3 Vassilatis D.K.... Gaitanaris G.A. (2003)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
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External Searches for MRGPRG gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MRGPRG gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRGPRG gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRGPRG gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRGPRG | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MRGPRG gene:
Search GeneIP for patents involving MRGPRG
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRGPRG gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRGPRG | | Browse OriGene genome-wide validated SYBR primer pairs | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRGPRG | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRG | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRG | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MRGPRG | | OriGene Custom Protein Services for MRGPRG | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRGPRG | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRGPRG | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRGPRG | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRGPRG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRGPRG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRGPRG |
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 | | | MRGPRG Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for MRGPRG |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MRGPRG |
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