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Aliases for MRGPRF Gene

Aliases for MRGPRF Gene

  • MAS-Related GPR, Member F 2 3
  • MRGF 3 4 6
  • G Protein-Coupled Receptor 168 2 3
  • G Protein-Coupled Receptor 140 2 3
  • G-Protein Coupled Receptor 140 3 4
  • G-Protein Coupled Receptor 168 3 4
  • Mas-Related Gene F Protein 3 4
  • GPR140 3 4
  • GPR168 3 4
  • RTA 3 6
  • Mas-Related G-Protein Coupled Receptor Member F 3
  • Seven Transmembrane Helix Receptor 3
  • Mas-Related G Protein-Coupled MRGF 3
  • G Protein-Coupled Receptor MrgF 3

External Ids for MRGPRF Gene

Previous HGNC Symbols for MRGPRF Gene

  • GPR168
  • GPR140

Previous GeneCards Identifiers for MRGPRF Gene

  • GC11M068548
  • GC11M068528
  • GC11M068771
  • GC11M065111

Summaries for MRGPRF Gene

GeneCards Summary for MRGPRF Gene

MRGPRF (MAS-Related GPR, Member F) is a Protein Coding gene. Diseases associated with MRGPRF include intestinal schistosomiasis. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX4.

UniProtKB/Swiss-Prot for MRGPRF Gene

  • Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRF Gene

Genomics for MRGPRF Gene

Regulatory Elements for MRGPRF Gene

Genomic Location for MRGPRF Gene

Start:
69,004,394 bp from pter
End:
69,013,409 bp from pter
Size:
9,016 bases
Orientation:
Minus strand

Genomic View for MRGPRF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRGPRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRF Gene

Proteins for MRGPRF Gene

  • Protein details for MRGPRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AM1-MRGRF_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor member F
    Protein Accession:
    Q96AM1
    Secondary Accessions:
    • B3KV43
    • Q8NBK8

    Protein attributes for MRGPRF Gene

    Size:
    343 amino acids
    Molecular mass:
    38171 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRGPRF Gene

Proteomics data for MRGPRF Gene at MOPED

Post-translational modifications for MRGPRF Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for MRGPRF Gene

No data available for DME Specific Peptides for MRGPRF Gene

Domains for MRGPRF Gene

Gene Families for MRGPRF Gene

HGNC:
  • GPCRAO :GPCR / Class A : Orphans
IUPHAR :

Protein Domains for MRGPRF Gene

Suggested Antigen Peptide Sequences for MRGPRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96AM1

UniProtKB/Swiss-Prot:

MRGRF_HUMAN :
  • Q96AM1
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRF: view

Function for MRGPRF Gene

Molecular function for MRGPRF Gene

UniProtKB/Swiss-Prot Function: Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).

Gene Ontology (GO) - Molecular Function for MRGPRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with MRGPRF: view
genes like me logo Genes that share phenotypes with MRGPRF: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRGPRF

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MRGPRF Gene

Localization for MRGPRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRF Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRGPRF Gene COMPARTMENTS Subcellular localization image for MRGPRF gene
Compartment Confidence
plasma membrane 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRGPRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MRGPRF: view

Pathways for MRGPRF Gene

SuperPathways for MRGPRF Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for MRGPRF Gene

Gene Ontology (GO) - Biological Process for MRGPRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with MRGPRF: view

No data available for Pathways by source for MRGPRF Gene

Transcripts for MRGPRF Gene

mRNA/cDNA for MRGPRF Gene

(8) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGPRF Gene

MAS-related GPR, member F:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRGPRF

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRF Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d
SP1: -
SP2: - - -
SP3: -
SP4:

Relevant External Links for MRGPRF Gene

GeneLoc Exon Structure for
MRGPRF
ECgene alternative splicing isoforms for
MRGPRF

Expression for MRGPRF Gene

mRNA expression in normal human tissues for MRGPRF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MRGPRF Gene

This gene is overexpressed in Colon - Sigmoid (4.7), Esophagus - Gastroesophageal Junction (4.2), and Uterus (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MRGPRF Gene

SOURCE GeneReport for Unigene cluster for MRGPRF Gene Hs.118513

genes like me logo Genes that share expressions with MRGPRF: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MRGPRF Gene

Orthologs for MRGPRF Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRGPRF 35
  • 99.71 (n)
  • 99.71 (a)
MRGPRF 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRGPRF 35
  • 89.99 (n)
  • 88.92 (a)
MRGPRF 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRGPRF 35
  • 89.6 (n)
  • 89.8 (a)
MRGPRF 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrgprf 35
  • 83.97 (n)
  • 86.01 (a)
Mrgprf 16
Mrgprf 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRGPRF 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRGPRF 36
  • 33 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrgprf 35
  • 83.67 (n)
  • 85.13 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
Species with no ortholog for MRGPRF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRF Gene

ENSEMBL:
Gene Tree for MRGPRF (if available)
TreeFam:
Gene Tree for MRGPRF (if available)

Paralogs for MRGPRF Gene

Paralogs for MRGPRF Gene

Selected SIMAP similar genes for MRGPRF Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MRGPRF: view

Variants for MRGPRF Gene

Sequence variations from dbSNP and Humsavar for MRGPRF Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1054252 -- 69,004,604(-) GCCTC(C/T)GGGAG utr-variant-3-prime
rs4930256 -- 69,006,843(+) ggtct(C/G)gaact intron-variant
rs11228436 -- 69,006,673(+) CTGGA(A/G)CGTGC intron-variant
rs11228437 -- 69,009,715(+) GAGGA(G/T)CCCAC intron-variant
rs11326908 -- 69,006,640(+) TTTTT(-/T)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRGPRF Gene

Variant ID Type Subtype PubMed ID
nsv527120 CNV Loss 19592680
nsv832196 CNV Loss 17160897
nsv468619 CNV Loss 19166990

Relevant External Links for MRGPRF Gene

HapMap Linkage Disequilibrium report
MRGPRF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRGPRF Gene

Disorders for MRGPRF Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MRGPRF Gene including...

Search for MRGPRF Gene in MalaCards »

(1) University of Copenhagen DISEASES for MRGPRF Gene

genes like me logo Genes that share disorders with MRGPRF: view

No data available for UniProtKB/Swiss-Prot for MRGPRF Gene

Publications for MRGPRF Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for MRGPRF Gene

Sources for MRGPRF Gene

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