Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRGPRF Gene

Aliases for MRGPRF Gene

  • MAS Related GPR Family Member F 2 3 5
  • G-Protein Coupled Receptor 140 3 4
  • G-Protein Coupled Receptor 168 3 4
  • Mas-Related Gene F Protein 3 4
  • MAS-Related GPR, Member F 2 3
  • GPR140 3 4
  • GPR168 3 4
  • MRGF 3 4
  • Mas-Related G-Protein Coupled Receptor Member F 3
  • Seven Transmembrane Helix Receptor 3
  • Mas-Related G Protein-Coupled MRGF 3
  • G Protein-Coupled Receptor MrgF 3
  • G Protein-Coupled Receptor 168 2
  • G Protein-Coupled Receptor 140 2
  • RTA 3

External Ids for MRGPRF Gene

Previous HGNC Symbols for MRGPRF Gene

  • GPR168
  • GPR140

Previous GeneCards Identifiers for MRGPRF Gene

  • GC11M068548
  • GC11M068528
  • GC11M068771
  • GC11M065111

Summaries for MRGPRF Gene

GeneCards Summary for MRGPRF Gene

MRGPRF (MAS Related GPR Family Member F) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRD.

UniProtKB/Swiss-Prot for MRGPRF Gene

  • Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).

Additional gene information for MRGPRF Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRF Gene

Genomics for MRGPRF Gene

Regulatory Elements for MRGPRF Gene

Enhancers for MRGPRF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H068098 1.6 Ensembl ENCODE dbSUPER 60.2 +912.4 912367 4.7 FOXA2 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF143 SP5 ZC3H11A KMT5B MRGPRF-AS1 PPP6R3 MRGPRF ENSG00000261625 ENSG00000260808 TPCN2 RAD9A KDM2A SSH3
GH11H068902 1.2 ENCODE 41 +109.1 109084 2.7 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 IGHMBP2 KMT5B ORAOV1 MRGPRF MRGPRF-AS1 ENSG00000261625 LOC105369364 PPP6R3 MRPL21 ENSG00000255741
GH11H068125 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.7 +885.4 885436 4 FOXA2 MLX ARID4B DMAP1 ETS1 SP3 MCM3 SP5 MXD4 MIER2 PPP6R3 MRGPRF ENSG00000255031 CLCF1 MRGPRF-AS1 TPCN2 LOC105369362 CORO1B ENSG00000261625 ENSG00000260808
GH11H068836 1.4 ENCODE dbSUPER 14.3 +172.7 172665 8.1 HDGF FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IGHMBP2 PPP6R3 MRGPRF-AS1 KMT5B ENSG00000261625 ORAOV1 MRGPRF ENSG00000260808 TPCN2 MRPL21
GH11H069292 2 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -285.2 -285198 11.6 HDGF PKNOX1 ARID4B SIN3A YBX1 FEZF1 ZBTB7B ZNF766 ZNF143 ZNF207 ORAOV1 PPP6R3 ENSG00000260808 TPCN2 FADD IGHMBP2 LRP5 ANO1 MRGPRF-AS1 MRGPRF
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRGPRF on UCSC Golden Path with GeneCards custom track

Promoters for MRGPRF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000041299 409 1201 CTCF ATF1 MAX ATF2 RAD21 POLR2A CREB1 KDM1A ATF7 MYC

Genomic Locations for MRGPRF Gene

Genomic Locations for MRGPRF Gene
chr11:69,004,394-69,013,409
(GRCh38/hg38)
Size:
9,016 bases
Orientation:
Minus strand
chr11:68,771,862-68,780,877
(GRCh37/hg19)

Genomic View for MRGPRF Gene

Genes around MRGPRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGPRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGPRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRF Gene

Proteins for MRGPRF Gene

  • Protein details for MRGPRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AM1-MRGRF_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor member F
    Protein Accession:
    Q96AM1
    Secondary Accessions:
    • B3KV43
    • Q8NBK8

    Protein attributes for MRGPRF Gene

    Size:
    343 amino acids
    Molecular mass:
    38171 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRGPRF Gene

Post-translational modifications for MRGPRF Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for MRGPRF Gene

No data available for DME Specific Peptides for MRGPRF Gene

Domains & Families for MRGPRF Gene

Gene Families for MRGPRF Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for MRGPRF Gene

Suggested Antigen Peptide Sequences for MRGPRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96AM1

UniProtKB/Swiss-Prot:

MRGRF_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRF: view

Function for MRGPRF Gene

Molecular function for MRGPRF Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).

Phenotypes From GWAS Catalog for MRGPRF Gene

Gene Ontology (GO) - Molecular Function for MRGPRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
genes like me logo Genes that share ontologies with MRGPRF: view
genes like me logo Genes that share phenotypes with MRGPRF: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRGPRF Gene

Localization for MRGPRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRF Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRGPRF gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRGPRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA,IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with MRGPRF: view

Pathways & Interactions for MRGPRF Gene

SuperPathways for MRGPRF Gene

No Data Available

Interacting Proteins for MRGPRF Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309782%0d%0a9606.ENSP00000343535%0d%0a9606.ENSP00000363999%0d%0a
Selected Interacting proteins: ENSP00000309782 for MRGPRF Gene via STRING

Gene Ontology (GO) - Biological Process for MRGPRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with MRGPRF: view

No data available for Pathways by source and SIGNOR curated interactions for MRGPRF Gene

Drugs & Compounds for MRGPRF Gene

No Compound Related Data Available

Transcripts for MRGPRF Gene

mRNA/cDNA for MRGPRF Gene

(3) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGPRF Gene

MAS-related GPR, member F:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRF Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d
SP1: -
SP2: - - -
SP3: -
SP4:

Relevant External Links for MRGPRF Gene

GeneLoc Exon Structure for
MRGPRF
ECgene alternative splicing isoforms for
MRGPRF

Expression for MRGPRF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRGPRF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MRGPRF Gene

This gene is overexpressed in Colon - Sigmoid (x4.7), Esophagus - Gastroesophageal Junction (x4.2), and Uterus (x4.1).

Protein differential expression in normal tissues from HIPED for MRGPRF Gene

This gene is overexpressed in Gallbladder (14.8), Colon (11.8), and Prostate (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MRGPRF Gene



Protein tissue co-expression partners for MRGPRF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRGPRF Gene:

MRGPRF

SOURCE GeneReport for Unigene cluster for MRGPRF Gene:

Hs.118513

Evidence on tissue expression from TISSUES for MRGPRF Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with MRGPRF: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRGPRF Gene

Orthologs for MRGPRF Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRGPRF 33 34
  • 99.71 (n)
cow
(Bos Taurus)
Mammalia MRGPRF 33 34
  • 89.99 (n)
dog
(Canis familiaris)
Mammalia MRGPRF 33 34
  • 89.6 (n)
mouse
(Mus musculus)
Mammalia Mrgprf 33 16 34
  • 83.97 (n)
rat
(Rattus norvegicus)
Mammalia Mrgprf 33
  • 83.67 (n)
oppossum
(Monodelphis domestica)
Mammalia MRGPRF 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRGPRF 34
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 32 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 25 (a)
ManyToMany
-- 34
  • 25 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
-- 34
  • 22 (a)
ManyToMany
-- 34
  • 21 (a)
ManyToMany
Species where no ortholog for MRGPRF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRF Gene

ENSEMBL:
Gene Tree for MRGPRF (if available)
TreeFam:
Gene Tree for MRGPRF (if available)

Paralogs for MRGPRF Gene

Paralogs for MRGPRF Gene

(8) SIMAP similar genes for MRGPRF Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MRGPRF: view

Variants for MRGPRF Gene

Sequence variations from dbSNP and Humsavar for MRGPRF Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000005074 -- 69,014,742(+) AGCAG(A/G/T)CGTTT intron-variant, upstream-variant-2KB
rs1000439978 -- 69,015,004(+) GCAGC(A/G)GGGCA intron-variant, upstream-variant-2KB
rs1000737094 -- 69,012,962(+) TGCCC(C/T)GACAG intron-variant, upstream-variant-2KB
rs1000849518 -- 69,011,059(+) GAGCT(C/G)GGCAT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001530743 -- 69,008,675(+) TGTTC(A/G)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRGPRF Gene

Variant ID Type Subtype PubMed ID
nsv832196 CNV loss 17160897
nsv555299 CNV loss 21841781
nsv527120 CNV loss 19592680
nsv468619 CNV loss 19166990

Variation tolerance for MRGPRF Gene

Gene Damage Index Score: 8.94; 87.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRGPRF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRGPRF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRGPRF Gene

Disorders for MRGPRF Gene

Relevant External Links for MRGPRF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRGPRF

No disorders were found for MRGPRF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGPRF Gene

Publications for MRGPRF Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  5. Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes. (PMID: 24583173) Premzl M (Gene 2014) 3 60

Products for MRGPRF Gene

Sources for MRGPRF Gene

Content
Loading form....