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Aliases for MRGPRF Gene

Aliases for MRGPRF Gene

  • MAS Related GPR Family Member F 2 3 5
  • G Protein-Coupled Receptor 168 2 3
  • G Protein-Coupled Receptor 140 2 3
  • G-Protein Coupled Receptor 140 3 4
  • G-Protein Coupled Receptor 168 3 4
  • Mas-Related Gene F Protein 3 4
  • MAS-Related GPR, Member F 2 3
  • GPR140 3 4
  • GPR168 3 4
  • MRGF 3 4
  • Seven Transmembrane Helix Receptor 3
  • Mas-Related G Protein-Coupled MRGF 3
  • G Protein-Coupled Receptor MrgF 3
  • RTA 3

External Ids for MRGPRF Gene

Previous HGNC Symbols for MRGPRF Gene

  • GPR168
  • GPR140

Previous GeneCards Identifiers for MRGPRF Gene

  • GC11M068548
  • GC11M068528
  • GC11M068771
  • GC11M065111

Summaries for MRGPRF Gene

GeneCards Summary for MRGPRF Gene

MRGPRF (MAS Related GPR Family Member F) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX4.

UniProtKB/Swiss-Prot for MRGPRF Gene

  • Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRF Gene

Genomics for MRGPRF Gene

Regulatory Elements for MRGPRF Gene

Enhancers for MRGPRF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRGPRF on UCSC Golden Path with GeneCards custom track

Promoters for MRGPRF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRGPRF on UCSC Golden Path with GeneCards custom track

Genomic Location for MRGPRF Gene

69,004,394 bp from pter
69,013,409 bp from pter
9,016 bases
Minus strand

Genomic View for MRGPRF Gene

Genes around MRGPRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGPRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGPRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRF Gene

Proteins for MRGPRF Gene

  • Protein details for MRGPRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mas-related G-protein coupled receptor member F
    Protein Accession:
    Secondary Accessions:
    • B3KV43
    • Q8NBK8

    Protein attributes for MRGPRF Gene

    343 amino acids
    Molecular mass:
    38171 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRGPRF Gene

Proteomics data for MRGPRF Gene at MOPED

Post-translational modifications for MRGPRF Gene

  • Glycosylation at Asn 4
  • Modification sites at PhosphoSitePlus

Other Protein References for MRGPRF Gene

No data available for DME Specific Peptides for MRGPRF Gene

Domains & Families for MRGPRF Gene

Gene Families for MRGPRF Gene

Protein Domains for MRGPRF Gene

Suggested Antigen Peptide Sequences for MRGPRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRF: view

Function for MRGPRF Gene

Molecular function for MRGPRF Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).
genes like me logo Genes that share phenotypes with MRGPRF: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MRGPRF

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRGPRF Gene

Localization for MRGPRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRF Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MRGPRF Gene COMPARTMENTS Subcellular localization image for MRGPRF gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 4

Gene Ontology (GO) - Cellular Components for MRGPRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0031965 nuclear membrane IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MRGPRF: view

Pathways & Interactions for MRGPRF Gene

SuperPathways for MRGPRF Gene

No Data Available

Interacting Proteins for MRGPRF Gene

Gene Ontology (GO) - Biological Process for MRGPRF Gene


No data available for Pathways by source and SIGNOR curated interactions for MRGPRF Gene

Drugs & Compounds for MRGPRF Gene

No Compound Related Data Available

Transcripts for MRGPRF Gene


(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGPRF Gene

MAS-related GPR, member F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRF Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d
SP1: -
SP2: - - -
SP3: -

Relevant External Links for MRGPRF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRGPRF Gene

mRNA expression in normal human tissues for MRGPRF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MRGPRF Gene

This gene is overexpressed in Colon - Sigmoid (x4.7), Esophagus - Gastroesophageal Junction (x4.2), and Uterus (x4.1).

Protein differential expression in normal tissues from HIPED for MRGPRF Gene

This gene is overexpressed in Gallbladder (14.8), Colon (11.8), and Prostate (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MRGPRF Gene

SOURCE GeneReport for Unigene cluster for MRGPRF Gene Hs.118513

genes like me logo Genes that share expression patterns with MRGPRF: view

Protein tissue co-expression partners for MRGPRF Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MRGPRF Gene

Orthologs for MRGPRF Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRF Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRGPRF 35
  • 89.99 (n)
  • 88.92 (a)
  • 89 (a)
(Canis familiaris)
Mammalia MRGPRF 35
  • 89.6 (n)
  • 89.8 (a)
  • 90 (a)
(Mus musculus)
Mammalia Mrgprf 35
  • 83.97 (n)
  • 86.01 (a)
Mrgprf 16
Mrgprf 36
  • 86 (a)
(Pan troglodytes)
Mammalia MRGPRF 35
  • 99.71 (n)
  • 99.71 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrgprf 35
  • 83.67 (n)
  • 85.13 (a)
(Monodelphis domestica)
Mammalia MRGPRF 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia MRGPRF 36
  • 33 (a)
(Gallus gallus)
Aves -- 36
  • 24 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
-- 36
  • 27 (a)
-- 36
  • 30 (a)
-- 36
  • 29 (a)
-- 36
  • 25 (a)
-- 36
  • 28 (a)
-- 36
  • 28 (a)
-- 36
  • 28 (a)
-- 36
  • 32 (a)
-- 36
  • 21 (a)
-- 36
  • 25 (a)
-- 36
  • 26 (a)
-- 36
  • 24 (a)
-- 36
  • 22 (a)
-- 36
  • 28 (a)
-- 36
  • 28 (a)
Species with no ortholog for MRGPRF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRF Gene

Gene Tree for MRGPRF (if available)
Gene Tree for MRGPRF (if available)

Paralogs for MRGPRF Gene

Paralogs for MRGPRF Gene

(8) SIMAP similar genes for MRGPRF Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MRGPRF: view

Variants for MRGPRF Gene

Sequence variations from dbSNP and Humsavar for MRGPRF Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11544721 - 69,009,855(-) GAACA(A/G)GGTAA reference, missense
rs1054252 -- 69,004,604(-) GCCTC(C/T)GGGAG utr-variant-3-prime
rs11544722 -- 69,005,935(-) CTCTG(C/T)ATGTT reference, synonymous-codon
rs11601146 -- 69,006,824(+) TCGCC(A/G)TGTTG intron-variant
rs11601763 -- 69,008,249(+) CTCTC(C/T)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRGPRF Gene

Variant ID Type Subtype PubMed ID
nsv527120 CNV Loss 19592680
nsv832196 CNV Loss 17160897
nsv468619 CNV Loss 19166990

Variation tolerance for MRGPRF Gene

Gene Damage Index Score: 8.94; 87.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRGPRF Gene

Disorders for MRGPRF Gene

Relevant External Links for MRGPRF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRGPRF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGPRF Gene

Publications for MRGPRF Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes. (PMID: 24583173) Premzl M. (Gene 2014) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for MRGPRF Gene

Sources for MRGPRF Gene