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Aliases for MRGPRE Gene

Aliases for MRGPRE Gene

  • MAS-Related GPR, Member E 2 3
  • MRGE 3 4 6
  • G Protein-Coupled Receptor 167 2 3
  • G-Protein Coupled Receptor 167 3 4
  • GPR167 3 4
  • Mas-Related G-Protein Coupled Receptor Member E 3
  • Mas-Related G Protein-Coupled Receptor F 3
  • Mas-Related G Protein-Coupled MRGE 3
  • MGRF 3

External Ids for MRGPRE Gene

Previous HGNC Symbols for MRGPRE Gene

  • GPR167

Previous GeneCards Identifiers for MRGPRE Gene

  • GC11M003214
  • GC11M003206

Summaries for MRGPRE Gene

GeneCards Summary for MRGPRE Gene

MRGPRE (MAS-Related GPR, Member E) is a Protein Coding gene. Diseases associated with MRGPRE include intestinal schistosomiasis. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX4.

UniProtKB/Swiss-Prot for MRGPRE Gene

  • Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain

Gene Wiki entry for MRGPRE Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRE Gene

Genomics for MRGPRE Gene

Regulatory Elements for MRGPRE Gene

Genomic Location for MRGPRE Gene

Start:
3,227,698 bp from pter
End:
3,232,386 bp from pter
Size:
4,689 bases
Orientation:
Minus strand

Genomic View for MRGPRE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRGPRE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRE Gene

Proteins for MRGPRE Gene

  • Protein details for MRGPRE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SM8-MRGRE_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor member E
    Protein Accession:
    Q86SM8
    Secondary Accessions:
    • Q2M1V7

    Protein attributes for MRGPRE Gene

    Size:
    312 amino acids
    Molecular mass:
    34286 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI04890.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI12204.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MRGPRE Gene

Proteomics data for MRGPRE Gene at MOPED

Post-translational modifications for MRGPRE Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRGPRE Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRGPRE Gene

Domains for MRGPRE Gene

Gene Families for MRGPRE Gene

HGNC:
  • GPCRAO :GPCR / Class A : Orphans
IUPHAR :

Protein Domains for MRGPRE Gene

Suggested Antigen Peptide Sequences for MRGPRE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86SM8

UniProtKB/Swiss-Prot:

MRGRE_HUMAN :
  • Q86SM8
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRE: view

Function for MRGPRE Gene

Molecular function for MRGPRE Gene

UniProtKB/Swiss-Prot Function: Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain

Gene Ontology (GO) - Molecular Function for MRGPRE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with MRGPRE: view

Phenotypes for MRGPRE Gene

GenomeRNAi human phenotypes for MRGPRE:
genes like me logo Genes that share phenotypes with MRGPRE: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRGPRE

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MRGPRE Gene

Localization for MRGPRE Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRE Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRGPRE Gene COMPARTMENTS Subcellular localization image for MRGPRE gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for MRGPRE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MRGPRE: view

Pathways for MRGPRE Gene

SuperPathways for MRGPRE Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for MRGPRE Gene

Gene Ontology (GO) - Biological Process for MRGPRE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with MRGPRE: view

No data available for Pathways by source for MRGPRE Gene

Transcripts for MRGPRE Gene

mRNA/cDNA for MRGPRE Gene

(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGPRE Gene

MAS-related GPR, member E:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRGPRE

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MRGPRE

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRE Gene

No ASD Table

Relevant External Links for MRGPRE Gene

GeneLoc Exon Structure for
MRGPRE
ECgene alternative splicing isoforms for
MRGPRE

Expression for MRGPRE Gene

mRNA expression in normal human tissues for MRGPRE Gene

SOURCE GeneReport for Unigene cluster for MRGPRE Gene Hs.745512

genes like me logo Genes that share expressions with MRGPRE: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MRGPRE Gene

Orthologs for MRGPRE Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRGPRE 35
  • 99.04 (n)
  • 99.36 (a)
MRGPRE 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 29 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 30 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mrgpre 35
  • 80.81 (n)
  • 76.77 (a)
Mrgpre 16
Mrgpre 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRGPRE 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Mrgpre 35
  • 80.13 (n)
  • 75.42 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
Species with no ortholog for MRGPRE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRE Gene

ENSEMBL:
Gene Tree for MRGPRE (if available)
TreeFam:
Gene Tree for MRGPRE (if available)

Paralogs for MRGPRE Gene

Paralogs for MRGPRE Gene

Selected SIMAP similar genes for MRGPRE Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MRGPRE: view

Variants for MRGPRE Gene

Sequence variations from dbSNP and Humsavar for MRGPRE Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4391795 - 3,228,322(+) GGCGC(C/T)GCTGA missense, reference
rs4405289 -- 3,228,171(+) GTGGG(A/G)GCCGC reference, missense
rs4758557 -- 3,232,234(+) AGAGC(C/T)TCTGG utr-variant-5-prime
rs4758558 -- 3,232,626(+) CTGCC(A/G)GCCCC upstream-variant-2KB
rs4998520 -- 3,227,385(+) AAGGC(A/G)AGCTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MRGPRE Gene

Variant ID Type Subtype PubMed ID
dgv1015n71 CNV Loss 21882294
nsv7649 CNV Loss 18451855
dgv334e1 CNV Complex 17122850
dgv335e1 CNV Complex 17122850
nsv428245 CNV Gain 18775914
dgv336e1 CNV Complex 17122850
nsv523703 CNV Loss 19592680

Relevant External Links for MRGPRE Gene

HapMap Linkage Disequilibrium report
MRGPRE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRGPRE Gene

Disorders for MRGPRE Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MRGPRE Gene including...

Search for MRGPRE Gene in MalaCards »

(1) University of Copenhagen DISEASES for MRGPRE Gene

genes like me logo Genes that share disorders with MRGPRE: view

No data available for UniProtKB/Swiss-Prot for MRGPRE Gene

Publications for MRGPRE Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PMID: 11551509) Dong X. … Anderson D.J. (Cell 2001) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. A genome-wide association study of brain lesion distribution in multiple sclerosis. (PMID: 23412934) Gourraud P.A. … Baranzini S.E. (Brain 2013) 3

Products for MRGPRE Gene

Sources for MRGPRE Gene

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