MRGPRE Gene
protein-coding GIFtS: 40
GCID: GC11M003248
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MAS-related GPR, member E(Previous name: G protein-coupled receptor 167 )
(Previous symbol: GPR167)
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Aliases
for MRGPRE gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MAS-Related GPR, Member E1 2 | | G-Protein Coupled Receptor 1672 3 | | GPR1671 2 3 | | MrgE1 | | MRGE2 3 5 | | Mas-Related G Protein-Coupled MRGE2 | | G Protein-Coupled Receptor 1671 2 | | Mas-Related G-Protein Coupled Receptor Member E2 |
Export aliases for MRGPRE gene to outside databasesPrevious GC identifers: GC11M003214 GC11M003206 |
Summaries
for MRGPRE gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MRGRE_HUMAN, Q86SM8Function: Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulationof pain
Gene Wiki entry for MRGPRE
|
Genomic Views
for MRGPRE gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRGPRE gene promoter:
AhR MyoD Tal-1beta NF-kappaB E47 Arnt NF-kappaB2 SEF-1 (1) NF-kappaB1 LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRGPRE
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRGPRE |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.5MRGPRE Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M003248: view genomic region
(about GC identifiers)
Start:
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3,248,883 bp from pter |
End:
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3,253,616 bp from pter |
Size:
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4,734 bases |
Orientation:
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minus strand |
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Proteins
for MRGPRE gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MRGRE_HUMAN, Q86SM8 (See
protein sequence)Recommended Name: Mas-related G-protein coupled receptor member E Size: 311 amino acids; 34155 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q2M1V7Explore the universe of human proteins at neXtProt for MRGPRE: NX_Q86SM8
MRGPRE Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001034254.2
ENSEMBL proteins: ENSP00000374482 ENSP00000393251
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
MRGPRE for ontologies About GeneDecksing
MRGPRE Antibody Products:
Assay Products for MRGPRE: |
Protein
Domains /
Families
for MRGPRE gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRGPRE for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86SM8ProtoNet protein and cluster: Q86SM8 UniProtKB/Swiss-Prot: MRGRE_HUMAN, Q86SM8Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily |
Function
for MRGPRE gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MRGRE_HUMAN, Q86SM8Function: Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulationof pain
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRE (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRE
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRGPRE (NM_001039165) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRGPRE | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRGPRE |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRE |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- |
MRGPRE for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MRGPRE:
|
Pathways & Interactions
for MRGPRE gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRGPRE
|
Drugs & Compounds
for MRGPRE gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRGPRE
Search CenterWatch for drugs/clinical trials and news about MRGPRE / MRGRE
|
Transcripts
for MRGPRE gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRGPRE gene: NM_001039165.2 Unigene Cluster for MRGPRE: MAS-related GPR, member E Hs.190988 [show with all ESTs]Unigene Representative Sequence: AK2939402 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000389832(uc001lxq.4) ENST00000436689
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRE (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRE
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRGPRE (NM_001039165) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRGPRE | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRGPRE |
Additional cDNA sequence: AK293940.1 AY255572.1 BC104889.1 BC112203.1 2 DOTS entries: DT.100682213 DT.75100813 1 AceView cDNA sequence: AY255572
GeneLoc Exon Structure
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Expression
for MRGPRE gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRGPRE expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MRGPRE Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.190988
SABiosciences Expression via Pathway-Focused PCR Array including MRGPRE:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRGPRE
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRGPRE | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRGPRE | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRGPRE | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRE |
Orthologs
for MRGPRE gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MRGPRE gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for MRGPRE (if available)
TreeFam Gene Tree for MRGPRE (if available) |
Paralogs
for MRGPRE gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRGPRE gene
- MRGPRX32 MRGPRX12 MRGPRD2 MRGPRG2 MRGPRX22 MAS12 MAS1L2 MRGPRF2
- MRGPRX42
9 SIMAP similar genes for MRGPRE using alignment to 3 protein entries: MRGRE_HUMAN (see all proteins):MRGPRX1 MRGPRD MRGPRX2 MRGPRX3 MRGPRX4 MRGPRF
MRGPRG MAS1 MAS1L
MRGPRE for paralogs About GeneDecksing
|
Genomic Variants
for MRGPRE gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRGPRE (3248883 - 3253616 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MRGPRE
1 CNV: 3833 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRGPRE |
|
Disorders
/ Diseases
for MRGPRE gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRGPRE for disorders About GeneDecksing
OMIM gene information: 607232
OMIM disorders: --
5  diseases for MRGPRE: About MalaCardsarrhythmogenic right ventricular dysplasia gastroesophageal reflux disease intestinal schistosomiasis schistosomiasis
neuronitis
1 disease from the University of Copenhagen DISEASES database for MRGPRE:Intestinal schistosomiasis Export disorders for MRGPRE gene to outside databases
|
Publications
for MRGPRE gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRGPRE gene integrated from 9 sources:
(articles sorted by number of sources associating them with MRGPRE) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The G protein-coupled receptor repertoires of human and mouse. (PubMed id 12679517)1, 2 Vassilatis D.K.... Gaitanaris G.A. (2003)
- A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PubMed id 11551509)1, 3 Dong X.... Anderson D.J. (2001)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for MRGPRE gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MRGPRE gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRGPRE gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRGPRE gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRGPRE | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MRGPRE gene:
Search GeneIP for patents involving MRGPRE
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRGPRE gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRGPRE | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRGPRE | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRGPRE | | | OriGene Protein Over-expression Lysate for MRGPRE | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRGPRE | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRE | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRE | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MRGPRE | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MRGPRE | | OriGene Custom Protein Services for MRGPRE | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRGPRE | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRGPRE | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRGPRE | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRGPRE | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRGPRE | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRGPRE |
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 | | | MRGPRE Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRE |
|  |  |  | | | | ThermoFisher Antibodies for MRGPRE |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRGPRE |
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