MRGPRD Gene
protein-coding GIFtS : 48
GCID: GC11 M068747
MAS-related GPR, member D
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Aliasesfor MRGPRD gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases MAS-Related GPR, Member D 1 2 MrgD1 MRGD2 3 5 TGR72 Beta-Alanine Receptor2 3 Mas-Related G Protein-Coupled MRGD2 G-Protein Coupled Receptor TGR72 3 Mas-Related G-Protein Coupled Receptor Member D2
Export aliases for MRGPRD gene to outside databases Previous GC identifers: GC11M068523 GC11M068504 GC11M065086
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Summariesfor MRGPRD gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: MRGRD_HUMAN, Q8TDS7 Function : May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functionsas a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i) Gene Wiki entry for MRGPRD
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Genomic Viewsfor MRGPRD gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_167190.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MRGPRD gene promoter: AML1a Pax-6 COMP1 Other transcription factors Search SABiosciences Chromatin IP Primers for MRGPRD Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRGPRD
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q13.3 Ensembl cytogenetic band: 11q13.3 HGNC cytogenetic band: 11q13.3 MRGPRD Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M068747: view genomic region
(about GC identifiers )
Start:
68,747,490 bp from pter
End:
68,748,455 bp from pter
Size:
966 bases
Orientation:
minus strand
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Proteinsfor MRGPRD gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MRGRD_HUMAN, Q8TDS7 (See
protein sequence )Recommended Name: Mas-related G-protein coupled receptor member D Size : 321 amino acids; 36118 Da
Subcellular location : Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane butinternalized into the cytoplasm after treatment with beta-alanine
Sequence caution : Sequence=BAC06005.1; Type=Erroneous initiation;
Secondary accessions : Q8NGK7Explore the universe of human proteins at neXtProt for MRGPRD: NX_Q8TDS7 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8TDS7 MRGPRD Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_944605.2 ENSEMBL proteins: ENSP00000310631 Human Recombinant Protein Products for MRGPRD: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005886 plasma membrane
IEA -- GO:0016021 integral to membrane
IEA --
MRGPRD for ontologies About GeneDecksing MRGPRD Antibody Products: Assay Products for MRGPRD:
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Protein
Domains / Familiesfor MRGPRD gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MRGPRD for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8TDS7 ProtoNet protein and cluster: Q8TDS7
UniProtKB/Swiss-Prot: MRGRD_HUMAN, Q8TDS7 Similarity : Belongs to the G-protein coupled receptor 1 family. Mas subfamily
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Functionfor MRGPRD gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: MRGRD_HUMAN, Q8TDS7 Function : May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functionsas a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i)
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004930 G-protein coupled receptor activity
IEA --
MRGPRD for ontologies About GeneDecksing Phenotypes: 2 GenomeRNAi human phenotypes for MRGPRD : 5 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Mrgprd) :
MRGPRD for phenotypes About GeneDecksing Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MRGPRD (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MRGPRDOriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MRGPRD (NM_198923 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRGPRD Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MRGPRD
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRD
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Pathways & Interactionsfor MRGPRD gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRGPRD
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Drugs & Compoundsfor MRGPRD gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
MRGPRD for compounds About GeneDecksing Browse Tocris compounds for MRGPRD 1 HMDB Compound for MRGPRD About this table 3 Novoseek chemical compound relationships for MRGPRD gene About this table
Search CenterWatch for drugs/clinical trials and news about MRGPRD / MRGRD
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Transcriptsfor MRGPRD gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MRGPRD gene: NM_198923.2 Unigene Cluster for MRGPRD:
MAS-related GPR, member D Hs.527802 Unigene Representative Sequence: AY427820 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000309106 (uc010rqf.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MRGPRD (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MRGPRDOriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MRGPRD (NM_198923 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRGPRD Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MRGPRD
Additional cDNA sequence: AB154410.1 AY427820.1
1 DOTS entry : DT.101975814
3 AceView cDNA sequences :
AY427820 NM_198923 AB154410 GeneLoc Exon Structure
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Expression for MRGPRD gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MRGPRD expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGGGTCTTAAAbout this image MRGPRD expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
2 LifeMap In Vivo Development Anatomical Compartments/Cells Tissue Anatomical Compartment
Cell Category (developmental path) Brain Cerebral Cortex Brain Neural Tube Telencephalon Neural Tube Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See MRGPRD Protein Expression from SPIRE MOPED and PaxDB SOURCE GeneReport for Unigene cluster: Hs.527802 SABiosciences Expression via Pathway-Focused PCR Array including MRGPRD : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MRGPRDBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat MRGPRD QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MRGPRD QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MRGPRD In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRD
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Orthologsfor MRGPRD gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for MRGPRD gene from 2/9 species (see all 9 ) About this table
ENSEMBL Gene Tree for MRGPRD (if available)TreeFam Gene Tree for MRGPRD (if available)
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Paralogsfor MRGPRD gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MRGPRD gene MRGPRX3 2 MRGPRX1 2 MRGPRE 2 MRGPRG 2 MRGPRX2 2 MAS1 2 MAS1L 2 MRGPRF 2 MRGPRX4 2 9 SIMAP similar genes for MRGPRD using alignment to 1 protein entry: MRGRD_HUMAN :MRGPRX1 MRGPRX2 MRGPRX4 MRGPRX3 MRGPRE MRGPRF MRGPRG MAS1 MAS1L
MRGPRD for paralogs About GeneDecksing
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Genomic Variantsfor MRGPRD gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MRGPRD (68747490 - 68748455 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MRGPRD: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MRGPRD
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Disorders
/ Diseasesfor MRGPRD gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MRGPRD for disorders About GeneDecksing
OMIM gene information: 607231
OMIM disorders : --4 diseases for MRGPRD : About MalaCards malignant teratoma teratoma meningitis neuronitis 1 disease from the University of Copenhagen DISEASES database for MRGPRD :Meningitis Export disorders for MRGPRD gene to outside databases
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Publicationsfor MRGPRD gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MRGPRD gene integrated from 9 sources : (articles sorted by number of sources associating them with MRGPRD) Utopia : connect your pdf to the dynamic world of online information
Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. (PubMed id 12909716) 1 , 2 , 3 Zylka M.J....Anderson D.J. (2003) Identification of a G protein-coupled receptor specifically responsive to beta-alanine. (PubMed id 15037633) 1 , 2 , 9 Shinohara T.... Hinuma S. (2004) Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878) 1 , 2 Takeda S.... Mitaku S. (2002) A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PubMed id 11551509) 1 , 3 Dong X.... Anderson D.J. (2001) Angiotensin metabolites can stimulate receptors of the Mas-related genes family. (PubMed id 18636314) 1 , 9 Gembardt F....Walther T. (2008) MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability. (PubMed id 17442834) 9 Crozier R.A....Pausch M.H. (2007) Development of a homogeneous calcium mobilization assay for high throughput screening of mas-related gene receptor agonists. (PubMed id 17184592) 9 Zhang R....Wang M.W. (2007) Mutation of glycine receptor subunit creates beta-alanine receptor responsive to GABA. (PubMed id 8211147) 9 Schmieden V....Betz H. (1993)
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External Searches for MRGPRD gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MRGPRD gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MRGPRD gene
(According to HUGE )
About This Section --
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Specialized Databases showing MRGPRD gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MRGPRD Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MRGPRD gene: Search GeneIP for patents involving MRGPRD GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MRGPRD gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for MRGPRD OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MRGPRD OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MRGPRD OriGene Protein Over-expression Lysate for MRGPRD Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MRGPRD Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MRGPRD OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MRGPRD Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MRGPRD OriGene Custom Protein Services for MRGPRD OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRGPRD QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MRGPRD QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRGPRD QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MRGPRD QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MRGPRD QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MRGPRD
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRD
ThermoFisher Antibodies for MRGPRD
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MRGPRD
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