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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRGPRD Gene

protein-coding   GIFtS: 49
GCID: GC11M068747

MAS-Related GPR, Member D

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MAS-Related GPR, Member D1 2     TGR72
MRGD2 3 5     Mas-Related G Protein-Coupled MRGD2
Beta-Alanine Receptor2 3     Mas-Related G-Protein Coupled Receptor Member D2
G-Protein Coupled Receptor TGR72 3     

External Ids:    HGNC: 296261   Entrez Gene: 1165122   Ensembl: ENSG000001729387   OMIM: 6072315   UniProtKB: Q8TDS73   

Export aliases for MRGPRD gene to outside databases

Previous GC identifers: GC11M068523 GC11M068504 GC11M065086


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MRGPRD Gene: 
MRGPRD (MAS-related GPR, member D) is a protein-coding gene. Diseases associated with MRGPRD include malignant teratoma, and teratoma. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX3.

UniProtKB/Swiss-Prot: MRGRD_HUMAN, Q8TDS7
Function: May regulate nociceptor function and/or development, including the sensation or modulation of pain.
Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked
Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in
cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i)

Gene Wiki entry for MRGPRD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRGPRD gene promoter:
         AML1a   Pax-6   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRGPRD promoter sequence
   Search SABiosciences Chromatin IP Primers for MRGPRD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRGPRD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3   Ensembl cytogenetic band:  11q13.3   HGNC cytogenetic band: 11q13.3

MRGPRD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRGPRD gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M068747:  view genomic region     (about GC identifiers)

Start:
68,747,490 bp from pter      End:
68,748,455 bp from pter
Size:
966 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MRGRD_HUMAN, Q8TDS7 (See protein sequence)
Recommended Name: Mas-related G-protein coupled receptor member D  
Size: 321 amino acids; 36118 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane but
internalized into the cytoplasm after treatment with beta-alanine
Sequence caution: Sequence=BAC06005.1; Type=Erroneous initiation;
Secondary accessions: Q8NGK7

Explore the universe of human proteins at neXtProt for MRGPRD: NX_Q8TDS7

Explore proteomics data for MRGPRD at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TDS7

  • MRGPRD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MRGPRD Protein Expression
    REFSEQ proteins: NP_944605.2  
    ENSEMBL proteins: 
     ENSP00000310631  

    Human Recombinant Protein Products for MRGPRD: 
    EMD Millipore Purified and/or Recombinant MRGPRD Protein
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    OriGene Protein Over-expression Lysate for MRGPRD
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MRGPRD
    GenScript Custom Purified and Recombinant Proteins Services for MRGPRD
    Novus Biologicals MRGPRD Protein
    Novus Biologicals MRGPRD Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MRGPRD 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    MRGPRD for ontologies           About GeneDecksing



    MRGPRD Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for MRGPRD 

    Assay Products for MRGPRD: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MRGPRD 
    Cloud-Clone Corp. CLIAs for MRGPRD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: MRGPRD 
    Class A Orphans

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR026234 MRGPCRFAMILY
     IPR000276 GPCR_Rhodpsn
     IPR026232 MRGPCRD

    Graphical View of Domain Structure for InterPro Entry Q8TDS7

    ProtoNet protein and cluster: Q8TDS7

    UniProtKB/Swiss-Prot: MRGRD_HUMAN, Q8TDS7
    Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily


    MRGPRD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRGRD_HUMAN, Q8TDS7
    Function: May regulate nociceptor function and/or development, including the sensation or modulation of pain.
    Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked
    Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in
    cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    MRGPRD for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MRGPRD:
     Increased HPV18 LCR reporter a  Increased Salmonella enterica  

         5 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Mrgprd):
     behavior/neurological  integument  nervous system  normal  reproductive system 

    MRGPRD for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MRGPRD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MRGPRD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRGPRD 
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    miRNA
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    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MRGPRD
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    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MRGPRD (NM_198923)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRGPRD
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                         Customized lentivirus expression plasmids for stable overexpression of MRGPRD 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRGPRD

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    MRGPRD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MRGPRD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRGPRD (MRGRD)

    1 HMDB Compound for MRGPRD    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    1 IUPHAR Ligand for MRGPRD (MRGPRD)    About this table 
    LigandTypeActionAffinityPubmed IDs
    β-alanine
    AgonistFull agonist4.815037633 23396314

    3 Novoseek inferred chemical compound relationships for MRGPRD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beta-alanine 86.4 11 15037633 (5), 17442834 (3), 17184592 (1), 8211147 (1)
    gaba 41.2 2 15037633 (1), 8211147 (1)
    calcium 8.92 5 15037633 (2), 17184592 (2)

    Search CenterWatch for drugs/clinical trials and news about MRGPRD / MRGRD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRGPRD gene: 
    NM_198923.2  

    Unigene Cluster for MRGPRD:

    MAS-related GPR, member D
    Hs.527802
    Unigene Representative Sequence: AY427820
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000309106(uc010rqf.2)
    miRNA
    Products:
         
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MRGPRD
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MRGPRD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRGPRD
    Clone
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    OriGene clones in human, mouse for MRGPRD (see all 6)
    OriGene ORF clones in mouse, rat for MRGPRD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MRGPRD (NM_198923)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRGPRD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRGPRD
    Sirion Biotech Customized lentivirus for stable overexpression of MRGPRD 
                         Customized lentivirus expression plasmids for stable overexpression of MRGPRD 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MRGPRD
    OriGene qSTAR qPCR primer pairs in human, mouse for MRGPRD
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRGPRD
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRGPRD
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRGPRD

    Additional mRNA sequence: 

    AB154410.1 AY427820.1 

    1 DOTS entry:

    DT.101975814 

    3 AceView cDNA sequences:

    NM_198923 AY427820 AB154410 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRGPRD expression in normal human tissues (normalized intensities)      MRGPRD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGTCTTAA
    MRGPRD Expression
    About this image


    MRGPRD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex

    See MRGPRD Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.527802
        SABiosciences Expression via Pathway-Focused PCR Array including MRGPRD: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for MRGPRD
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRGPRD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MRGPRD gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrgprd1 , 5 MAS-related GPR, member D1, 5 69.62(n)1
    59.81(a)1
      7 (89.06 cM)5
    2115781  NM_203490.31  NP_987075.11 
     1453148355 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    22(a)
    1 → many
    JH376180.1(56001-57008)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 19)
    Uncharacterized protein
    (see all 19)
    35(a)
    33(a)
    (see all 19)
    many ↔ many
    many ↔ many
    (see all 19)
    4(16394563-16395360)
    4(16384879-16387025)


    ENSEMBL Gene Tree for MRGPRD (if available)
    TreeFam Gene Tree for MRGPRD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRGPRD gene
    MRGPRX32  MRGPRG2  MAS12  MAS1L2  MRGPRF2  MRGPRX42  MRGPRX12  MRGPRE2  
    MRGPRX22  
    9 SIMAP similar genes for MRGPRD using alignment to 1 protein entry:     MRGRD_HUMAN:
    MRGPRX1    MRGPRX2    MRGPRX4    MRGPRX3    MRGPRE    MRGPRF
    MRGPRG    MAS1    MAS1L

    MRGPRD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/117 SNPs in MRGPRD are shown (see all 117)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131332591,2
    C,F--68747092(+) TCACCT/CGAGGT 1 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs1145492841,2
    C,F--68747123(+) ATGCCG/CTCTTA 1 -- ds50011Minor allele frequency- C:0.12WA 118
    rs1421925621,2
    C--68747183(+) GTTATC/GCACCC 1 -- ds50010--------
    rs2008225121,2
    C--68747422(+) TGGGA-/GGCA  
      GCTCAC
    GGCTC
    1 -- ds50010--------
    rs1459100251,2
    C--68747460(+) GGCTCC/GCACAG 1 -- ds50010--------
    rs19397341,2
    C,F,H--68747485(+) TGGGCG/AGCTCT 1 -- ds500118Minor allele frequency- A:0.10NS EA NA WA EU 3159
    rs1433098521,2
    C,F--68747507(+) CTCATT/GGGTGC 2 /N /H mis12Minor allele frequency- G:0.01NA EU 3035
    rs1385733231,2
    C,F--68747529(+) GTCTCC/TCCACC 2 G syn12Minor allele frequency- T:0.01NA EU 2965
    rs2000555371,2
    --68747553(+) TCCTCA/GCGAAG 2 R syn10--------
    rs1454642031,2
    C--68747593(+) TGGTGG/TGCAGC 2 H P mis11Minor allele frequency- T:0.00NA 2434

    HapMap Linkage Disequilibrium report for MRGPRD (68747490 - 68748455 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MRGPRD:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897867CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MRGPRD
    DNA2.0 Custom Variant and Variant Library Synthesis for MRGPRD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607231    OMIM disorders: --

    4 diseases for MRGPRD:    About MalaCards
    malignant teratoma    teratoma    meningitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for MRGPRD:
    Meningitis

    MRGPRD for disorders           About GeneDecksing


    Export disorders for MRGPRD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRGPRD gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MRGPRD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. (PubMed id 12909716)1, 2, 3 Zylka M.J....Anderson D.J. (2003)
    2. Identification of a G protein-coupled receptor specifically responsive to beta-alanine. (PubMed id 15037633)1, 2, 9 Shinohara T.... Hinuma S. (2004)
    3. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (2002)
    4. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PubMed id 11551509)1, 3 Dong X.... Anderson D.J. (2001)
    5. Angiotensin metabolites can stimulate receptors of the Mas-related genes family. (PubMed id 18636314)1, 9 Gembardt F....Walther T. (2008)
    6. Discovery and characterization of alamandine: a novel component of the renin-angiotensin system. (PubMed id 23446738)1 Lautner R.Q....Santos R.A. (2013)
    7. MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability. (PubMed id 17442834)9 Crozier R.A....Pausch M.H. (2007)
    8. Development of a homogeneous calcium mobilization assay for high throughput screening of mas-related gene receptor agonists. (PubMed id 17184592)9 Zhang R....Wang M.W. (2007)
    9. Mutation of glycine receptor subunit creates beta-alanine receptor responsive to GABA. (PubMed id 8211147)9 Schmieden V....Betz H. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116512 HGNC: 29626 AceView: MRGPRD Ensembl:ENSG00000172938 euGenes: HUgn116512
    ECgene: MRGPRD H-InvDB: MRGPRD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRGPRD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRGPRD gene:
    Search GeneIP for patents involving MRGPRD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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