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MRGPRD Gene

protein-coding   GIFtS: 49
GCID: GC11M068747

MAS-Related GPR, Member D

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MAS-Related GPR, Member D1 2     TGR72
MRGD2 3 5     Mas-Related G Protein-Coupled MRGD2
Beta-Alanine Receptor2 3     Mas-Related G-Protein Coupled Receptor Member D2
G-Protein Coupled Receptor TGR72 3     

External Ids:    HGNC: 296261   Entrez Gene: 1165122   Ensembl: ENSG000001729387   OMIM: 6072315   UniProtKB: Q8TDS73   

Export aliases for MRGPRD gene to outside databases

Previous GC identifers: GC11M068523 GC11M068504 GC11M065086


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MRGPRD Gene:
MRGPRD (MAS-related GPR, member D) is a protein-coding gene. Diseases associated with MRGPRD include malignant teratoma, and teratoma. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX3.

UniProtKB/Swiss-Prot: MRGRD_HUMAN, Q8TDS7
Function: May regulate nociceptor function and/or development, including the sensation or modulation of pain.
Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked
Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in
cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i)

Gene Wiki entry for MRGPRD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRGPRD gene promoter:
         AML1a   Pax-6   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRGPRD promoter sequence
   Search Chromatin IP Primers for MRGPRD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRGPRD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3   Ensembl cytogenetic band:  11q13.3   HGNC cytogenetic band: 11q13.3

MRGPRD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRGPRD gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M068747:  view genomic region     (about GC identifiers)

Start:
68,747,490 bp from pter      End:
68,748,455 bp from pter
Size:
966 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MRGRD_HUMAN, Q8TDS7 (See protein sequence)
Recommended Name: Mas-related G-protein coupled receptor member D  
Size: 321 amino acids; 36118 Da
Sequence caution: Sequence=BAC06005.1; Type=Erroneous initiation;
Secondary accessions: Q8NGK7

Explore the universe of human proteins at neXtProt for MRGPRD: NX_Q8TDS7

Explore proteomics data for MRGPRD at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn2, Asn6, Asn16, Asn92

  • See MRGPRD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_944605.2  
    ENSEMBL proteins: 
     ENSP00000310631  

    MRGPRD Human Recombinant Protein Products:

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    MRGPRD Assay Products:

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    Cloud-Clone Corp. ELISAs for MRGPRD
    Cloud-Clone Corp. CLIAs for MRGPRD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: MRGPRD
    Class A Orphans

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR026234 MRGPCRFAMILY
     IPR000276 GPCR_Rhodpsn
     IPR026232 MRGPCRD

    Graphical View of Domain Structure for InterPro Entry Q8TDS7

    ProtoNet protein and cluster: Q8TDS7

    UniProtKB/Swiss-Prot: MRGRD_HUMAN, Q8TDS7
    Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily


    MRGPRD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRGRD_HUMAN, Q8TDS7
    Function: May regulate nociceptor function and/or development, including the sensation or modulation of pain.
    Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked
    Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in
    cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    MRGPRD for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MRGPRD:
     Increased HPV18 LCR reporter a  Increased Salmonella enterica  

         5 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Mrgprd):
     behavior/neurological  integument  nervous system  normal  reproductive system 

    MRGPRD for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRGPRD
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MRGPRD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRGPRD
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MRGPRD

    miRNA
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    GenScript: all cDNA clones in your preferred vector: MRGPRD (NM_198923)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRGPRD

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MRGRD_HUMAN, Q8TDS7: Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane but
    internalized into the cytoplasm after treatment with beta-alanine
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    MRGPRD for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including MRGPRD: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MRGPRD

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    MRGPRD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRGPRD (MRGRD)

    1 HMDB Compound for MRGPRD    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    1 IUPHAR Ligand for MRGPRD (MRGPRD)    About this table
    LigandTypeActionAffinityPubmed IDs
    beta-alanine
    AgonistFull agonist4.815037633 23396314

    3 Novoseek inferred chemical compound relationships for MRGPRD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beta-alanine 86.4 11 15037633 (5), 17442834 (3), 17184592 (1), 8211147 (1)
    gaba 41.2 2 15037633 (1), 8211147 (1)
    calcium 8.92 5 15037633 (2), 17184592 (2)



    MRGPRD for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MRGPRD gene: 
    NM_198923.2  

    Unigene Cluster for MRGPRD:

    MAS-related GPR, member D
    Hs.527802
    Unigene Representative Sequence: AY427820
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000309106(uc010rqf.2)
    miRNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRGPRD
      QuantiTect SYBR Green Assays in human, mouse, rat MRGPRD
      QuantiFast Probe-based Assays in human, mouse, rat MRGPRD

    Additional mRNA sequence: 

    AB154410.1 AY427820.1 

    1 DOTS entry:

    DT.101975814 

    3 AceView cDNA sequences:

    AY427820 NM_198923 AB154410 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRGPRD expression in normal human tissues (normalized intensities)      MRGPRD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGTCTTAA
    MRGPRD Expression
    About this image


    MRGPRD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
    MRGPRD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRGPRD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.527802
        Pathway & Disease-focused RT2 Profiler PCR Array including MRGPRD: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MRGPRD gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrgprd1 , 5 MAS-related GPR, member D1, 5 69.62(n)1
    59.81(a)1
      7 (89.06 cM)5
    2115781  NM_203490.31  NP_987075.11 
     1453148355 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    21(a)
    1 → many
    JH376180.1(56001-57008)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 16)
    Uncharacterized protein
    (see all 16)
    34(a)
    34(a)
    (see all 16)
    many ↔ many
    many ↔ many
    (see all 16)
    4(16488532-16489341)
    4(16394563-16395360)


    ENSEMBL Gene Tree for MRGPRD (if available)
    TreeFam Gene Tree for MRGPRD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MRGPRD gene
    MRGPRX32  MRGPRG2  MAS12  MAS1L2  MRGPRF2  MRGPRX42  MRGPRX12  MRGPRE2  
    MRGPRX22  
    9 SIMAP similar genes for MRGPRD using alignment to 1 protein entry:     MRGRD_HUMAN:
    MRGPRX1    MRGPRX2    MRGPRX4    MRGPRX3    MRGPRE    MRGPRF
    MRGPRG    MAS1    MAS1L

    MRGPRD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MRGPRD (see all 117)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131332591,2
    C,F--68747092(+) TCACCT/CGAGGT 1 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs1145492841,2
    C,F--68747123(+) ATGCCG/CTCTTA 1 -- ds50011Minor allele frequency- C:0.12WA 118
    rs1421925621,2
    C--68747183(+) GTTATC/GCACCC 1 -- ds50010--------
    rs2008225121,2
    C--68747422(+) TGGGA-/GGCA  
      GCTCAC
    GGCTC
    1 -- ds50010--------
    rs1459100251,2
    C--68747460(+) GGCTCC/GCACAG 1 -- ds50010--------
    rs19397341,2
    C,F,H--68747485(+) TGGGCG/AGCTCT 1 -- ds500118Minor allele frequency- A:0.10NS EA NA WA EU 3159
    rs1433098521,2
    C,F--68747507(+) CTCATT/GGGTGC 2 /N /H mis12Minor allele frequency- G:0.01NA EU 3035
    rs1385733231,2
    C,F--68747529(+) GTCTCC/TCCACC 2 G syn12Minor allele frequency- T:0.01NA EU 2965
    rs2000555371,2
    --68747553(+) TCCTCA/GCGAAG 2 R syn10--------
    rs1454642031,2
    C--68747593(+) TGGTGG/TGCAGC 2 H P mis11Minor allele frequency- T:0.00NA 2434

    HapMap Linkage Disequilibrium report for MRGPRD (68747490 - 68748455 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MRGPRD:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897867CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRGPRD
    DNA2.0 Custom Variant and Variant Library Synthesis for MRGPRD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607231    OMIM disorders: --

    5 diseases for MRGPRD:    About MalaCards
    malignant teratoma    teratoma    meningitis    cerebritis
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for MRGPRD:
    Meningitis

    MRGPRD for disorders           About GeneDecksing


    Export disorders for MRGPRD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRGPRD gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MRGPRD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. (PubMed id 12909716)1, 2, 3 Zylka M.J.... Anderson D.J. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. Identification of a G protein-coupled receptor specifically responsive to beta-alanine. (PubMed id 15037633)1, 2, 9 Shinohara T.... Hinuma S. (J. Biol. Chem. 2004)
    3. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (FEBS Lett. 2002)
    4. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PubMed id 11551509)1, 3 Dong X.... Anderson D.J. (Cell 2001)
    5. Angiotensin metabolites can stimulate receptors of the Mas-related genes family. (PubMed id 18636314)1, 9 Gembardt F....Walther T. (Mol. Cell. Biochem. 2008)
    6. Discovery and characterization of alamandine: a novel component of the renin-angiotensin system. (PubMed id 23446738)1 Lautner R.Q....Santos R.A. (Circ. Res. 2013)
    7. MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability. (PubMed id 17442834)9 Crozier R.A....Pausch M.H. (J. Neurosci. 2007)
    8. Development of a homogeneous calcium mobilization assay for high throughput screening of mas-related gene receptor agonists. (PubMed id 17184592)9 Zhang R....Wang M.W. (Acta Pharmacol. Sin. 2007)
    9. Mutation of glycine receptor subunit creates beta-alanine receptor responsive to GABA. (PubMed id 8211147)9 Schmieden V....Betz H. (Science 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 116512 HGNC: 29626 AceView: MRGPRD Ensembl:ENSG00000172938 euGenes: HUgn116512
    ECgene: MRGPRD H-InvDB: MRGPRD

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRGPRD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRGPRD gene:
    Search GeneIP for patents involving MRGPRD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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