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Aliases for MRGBP Gene

Aliases for MRGBP Gene

  • MRG/MORF4L Binding Protein 2 3
  • Up-Regulated In Colon Cancer 4 3 4
  • MRG-Binding Protein 3 4
  • C20orf20 3 4
  • URCC4 3 4
  • MRG(MORF4-Related Gene)-Binding Protein 3
  • Chromosome 20 Open Reading Frame 20 2
  • MRG/MORF4L-Binding Protein 3
  • C20orf20, 6
  • MRG15BP 3
  • Eaf7 3

External Ids for MRGBP Gene

Previous HGNC Symbols for MRGBP Gene

  • C20orf20

Previous GeneCards Identifiers for MRGBP Gene

  • GC20P061428

Summaries for MRGBP Gene

GeneCards Summary for MRGBP Gene

MRGBP (MRG/MORF4L Binding Protein) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening.

UniProtKB/Swiss-Prot for MRGBP Gene

  • Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGBP Gene

Genomics for MRGBP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRGBP Gene

Start:
62,796,452 bp from pter
End:
62,801,738 bp from pter
Size:
5,287 bases
Orientation:
Plus strand

Genomic View for MRGBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRGBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGBP Gene

No data available for Regulatory Elements for MRGBP Gene

Proteins for MRGBP Gene

  • Protein details for MRGBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV56-MRGBP_HUMAN
    Recommended name:
    MRG/MORF4L-binding protein
    Protein Accession:
    Q9NV56
    Secondary Accessions:
    • A8C4L5

    Protein attributes for MRGBP Gene

    Size:
    204 amino acids
    Molecular mass:
    22417 Da
    Quaternary structure:
    • Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MRGBP may interact directly with MORF4L1/MRG15 and MORF4L2/MRGX.

neXtProt entry for MRGBP Gene

Proteomics data for MRGBP Gene at MOPED

Post-translational modifications for MRGBP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRGBP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MRGBP Gene

Domains for MRGBP Gene

Protein Domains for MRGBP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MRGBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NV56

UniProtKB/Swiss-Prot:

MRGBP_HUMAN :
  • Q9NV56
Family:
  • Belongs to the EAF7 family.
genes like me logo Genes that share domains with MRGBP: view

No data available for Gene Families for MRGBP Gene

Function for MRGBP Gene

Molecular function for MRGBP Gene

UniProtKB/Swiss-Prot Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage

Gene Ontology (GO) - Molecular Function for MRGBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12963728
genes like me logo Genes that share ontologies with MRGBP: view

Phenotypes for MRGBP Gene

genes like me logo Genes that share phenotypes with MRGBP: view

Animal Model Products

CRISPR Products

miRNA for MRGBP Gene

miRTarBase miRNAs that target MRGBP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRGBP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRGBP Gene

Localization for MRGBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGBP Gene

Gene Ontology (GO) - Cellular Components for MRGBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0043189 H4/H2A histone acetyltransferase complex IEA --
genes like me logo Genes that share ontologies with MRGBP: view

No data available for Subcellular locations from COMPARTMENTS for MRGBP Gene

Pathways for MRGBP Gene

genes like me logo Genes that share pathways with MRGBP: view

Pathways by source for MRGBP Gene

Gene Ontology (GO) - Biological Process for MRGBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016568 chromatin modification IEA --
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with MRGBP: view

Transcripts for MRGBP Gene

mRNA/cDNA for MRGBP Gene

(184) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGBP Gene

MRG/MORF4L binding protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRGBP

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRGBP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - -
SP7: - -
SP8:
SP9:

Relevant External Links for MRGBP Gene

GeneLoc Exon Structure for
MRGBP
ECgene alternative splicing isoforms for
MRGBP

Expression for MRGBP Gene

mRNA expression in normal human tissues for MRGBP Gene

mRNA differential expression in normal tissues according to GTEx for MRGBP Gene

This gene is overexpressed in Testis (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRGBP Gene

SOURCE GeneReport for Unigene cluster for MRGBP Gene Hs.590870

genes like me logo Genes that share expressions with MRGBP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MRGBP Gene

Orthologs for MRGBP Gene

This gene was present in the common ancestor of animals.

Orthologs for MRGBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRGBP 35
  • 94.95 (n)
  • 95.68 (a)
MRGBP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C13H20orf20 35
  • 91.94 (n)
  • 96.77 (a)
C13H20orf20 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRGBP 35
  • 91.09 (n)
  • 97.67 (a)
MRGBP 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrgbp 35
  • 91.4 (n)
  • 97.31 (a)
Mrgbp 16
Mrgbp 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MRGBP 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrgbp 35
  • 90.68 (n)
  • 97.31 (a)
chicken
(Gallus gallus)
Aves C20ORF20 35
  • 79.37 (n)
  • 83.43 (a)
MRGBP 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRGBP 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3953 35
zebrafish
(Danio rerio)
Actinopterygii mrgbp 35
  • 67.4 (n)
  • 69.23 (a)
mrgbp 36
  • 61 (a)
OneToOne
zgc73167 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012361 35
  • 48.26 (n)
  • 37.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta MrgBP 35
  • 48.19 (n)
  • 33.7 (a)
MrgBP 36
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for MRGBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRGBP Gene

ENSEMBL:
Gene Tree for MRGBP (if available)
TreeFam:
Gene Tree for MRGBP (if available)

Paralogs for MRGBP Gene

No data available for Paralogs for MRGBP Gene

Variants for MRGBP Gene

Sequence variations from dbSNP and Humsavar for MRGBP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs856939 -- 62,794,506(+) caccg(C/T)ccggc upstream-variant-2KB
rs2273077 -- 62,797,470(+) GAGGC(C/T)CGTCC intron-variant
rs2294981 -- 62,798,263(+) GCAGG(C/T)GGAGC intron-variant
rs2294982 -- 62,798,573(+) ACTCT(C/G)TATTT intron-variant
rs6010746 -- 62,797,792(+) GTGAC(A/G)GGCGA intron-variant

Relevant External Links for MRGBP Gene

HapMap Linkage Disequilibrium report
MRGBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRGBP Gene

Disorders for MRGBP Gene

No disorders were found for MRGBP Gene.

No data available for UniProtKB/Swiss-Prot for MRGBP Gene

Publications for MRGBP Gene

  1. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PMID: 12963728) Cai Y. … Conaway J.W. (J. Biol. Chem. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain. (PMID: 16407074) Bowman B.R. … Quiocho F.A. (Structure 2006) 3 23
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for MRGBP Gene

Sources for MRGBP Gene

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