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Aliases for MRGBP Gene

Aliases for MRGBP Gene

  • MRG/MORF4L Binding Protein 2 3
  • Up-Regulated In Colon Cancer 4 3 4
  • MRG-Binding Protein 3 4
  • C20orf20 3 4
  • URCC4 3 4
  • MRG(MORF4-Related Gene)-Binding Protein 3
  • Chromosome 20 Open Reading Frame 20 2
  • MRG15BP 3
  • Eaf7 3

External Ids for MRGBP Gene

Previous HGNC Symbols for MRGBP Gene

  • C20orf20

Previous GeneCards Identifiers for MRGBP Gene

  • GC20P061428

Summaries for MRGBP Gene

GeneCards Summary for MRGBP Gene

MRGBP (MRG/MORF4L Binding Protein) is a Protein Coding gene. Among its related pathways are Chromatin organization.

UniProtKB/Swiss-Prot for MRGBP Gene

  • Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGBP Gene

Genomics for MRGBP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRGBP Gene

Chromosome:
20
Start:
62,796,453 bp from pter
End:
62,801,738 bp from pter
Size:
5,286 bases
Orientation:
Plus strand

Genomic View for MRGBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MRGBP Gene

No data available for Regulatory Elements for MRGBP Gene

Proteins for MRGBP Gene

  • Protein details for MRGBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV56-MRGBP_HUMAN
    Recommended name:
    MRG/MORF4L-binding protein
    Protein Accession:
    Q9NV56
    Secondary Accessions:
    • A8C4L5

    Protein attributes for MRGBP Gene

    Size:
    204 amino acids
    Molecular mass:
    22417 Da
    Quaternary structure:
    • Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MRGBP may interact directly with MORF4L1/MRG15 and MORF4L2/MRGX.

    Three dimensional structures from OCA and Proteopedia for MRGBP Gene

neXtProt entry for MRGBP Gene

Proteomics data for MRGBP Gene at MOPED

Post-translational modifications for MRGBP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRGBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRGBP Gene

Domains & Families for MRGBP Gene

Protein Domains for MRGBP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MRGBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NV56

UniProtKB/Swiss-Prot:

MRGBP_HUMAN :
  • Belongs to the EAF7 family.
Family:
  • Belongs to the EAF7 family.
genes like me logo Genes that share domains with MRGBP: view

No data available for Gene Families for MRGBP Gene

Function for MRGBP Gene

Molecular function for MRGBP Gene

UniProtKB/Swiss-Prot Function:
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage

Gene Ontology (GO) - Molecular Function for MRGBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12963728
genes like me logo Genes that share ontologies with MRGBP: view
genes like me logo Genes that share phenotypes with MRGBP: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRGBP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRGBP Gene

Localization for MRGBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGBP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRGBP Gene COMPARTMENTS Subcellular localization image for MRGBP gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for MRGBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0035267 NuA4 histone acetyltransferase complex IBA --
GO:0043189 H4/H2A histone acetyltransferase complex --
genes like me logo Genes that share ontologies with MRGBP: view

Pathways & Interactions for MRGBP Gene

genes like me logo Genes that share pathways with MRGBP: view

Pathways by source for MRGBP Gene

Gene Ontology (GO) - Biological Process for MRGBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0016573 histone acetylation IBA --
genes like me logo Genes that share ontologies with MRGBP: view

No data available for SIGNOR curated interactions for MRGBP Gene

Drugs & Compounds for MRGBP Gene

No Compound Related Data Available

Transcripts for MRGBP Gene

mRNA/cDNA for MRGBP Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(184) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGBP Gene

MRG/MORF4L binding protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRGBP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRGBP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - -
SP7: - -
SP8:
SP9:

Relevant External Links for MRGBP Gene

GeneLoc Exon Structure for
MRGBP
ECgene alternative splicing isoforms for
MRGBP

Expression for MRGBP Gene

mRNA expression in normal human tissues for MRGBP Gene

mRNA differential expression in normal tissues according to GTEx for MRGBP Gene

This gene is overexpressed in Testis (x6.1).

Protein differential expression in normal tissues from HIPED for MRGBP Gene

This gene is overexpressed in Breast (35.0), Peripheral blood mononuclear cells (9.0), and Testis (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRGBP Gene



SOURCE GeneReport for Unigene cluster for MRGBP Gene Hs.590870

genes like me logo Genes that share expression patterns with MRGBP: view

Protein tissue co-expression partners for MRGBP Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MRGBP Gene

Orthologs for MRGBP Gene

This gene was present in the common ancestor of animals.

Orthologs for MRGBP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C13H20orf20 35
  • 91.94 (n)
  • 96.77 (a)
C13H20orf20 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRGBP 35
  • 91.09 (n)
  • 97.67 (a)
MRGBP 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrgbp 35
  • 91.4 (n)
  • 97.31 (a)
Mrgbp 16
Mrgbp 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRGBP 35
  • 94.95 (n)
  • 95.68 (a)
MRGBP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrgbp 35
  • 90.68 (n)
  • 97.31 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MRGBP 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves C20ORF20 35
  • 79.37 (n)
  • 83.43 (a)
MRGBP 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRGBP 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3953 35
zebrafish
(Danio rerio)
Actinopterygii mrgbp 35
  • 67.4 (n)
  • 69.23 (a)
zgc73167 35
mrgbp 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012361 35
  • 48.26 (n)
  • 37.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta MrgBP 35
  • 48.19 (n)
  • 33.7 (a)
MrgBP 36
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for MRGBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRGBP Gene

ENSEMBL:
Gene Tree for MRGBP (if available)
TreeFam:
Gene Tree for MRGBP (if available)

Paralogs for MRGBP Gene

No data available for Paralogs for MRGBP Gene

Variants for MRGBP Gene

Sequence variations from dbSNP and Humsavar for MRGBP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs2273077 -- 62,797,470(+) GAGGC(C/T)CGTCC intron-variant
rs2294981 -- 62,798,263(+) GCAGG(C/T)GGAGC intron-variant
rs2294982 -- 62,798,573(+) ACTCT(C/G)TATTT intron-variant
rs6010746 -- 62,797,792(+) GTGAC(A/G)GGCGA intron-variant
rs6011385 -- 62,798,702(+) ATTCA(G/T)AAAAG intron-variant

Variation tolerance for MRGBP Gene

Residual Variation Intolerance Score: 36.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRGBP Gene

HapMap Linkage Disequilibrium report
MRGBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRGBP Gene

Disorders for MRGBP Gene

Relevant External Links for MRGBP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRGBP
genes like me logo Genes that share disorders with MRGBP: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGBP Gene

Publications for MRGBP Gene

  1. Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain. (PMID: 16407074) Bowman B.R. … Quiocho F.A. (Structure 2006) 23 67
  2. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PMID: 12963728) Cai Y. … Conaway J.W. (J. Biol. Chem. 2003) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for MRGBP Gene

Sources for MRGBP Gene

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