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Aliases for MRGBP Gene

Aliases for MRGBP Gene

  • MRG Domain Binding Protein 2 3 5
  • Up-Regulated In Colon Cancer 4 3 4
  • MRG/MORF4L Binding Protein 2 3
  • MRG-Binding Protein 3 4
  • C20orf20 3 4
  • URCC4 3 4
  • Chromosome 20 Open Reading Frame 20 2
  • MRG/MORF4L-Binding Protein 3
  • MRG15BP 3
  • Eaf7 3

External Ids for MRGBP Gene

Previous HGNC Symbols for MRGBP Gene

  • C20orf20

Previous GeneCards Identifiers for MRGBP Gene

  • GC20P061428

Summaries for MRGBP Gene

GeneCards Summary for MRGBP Gene

MRGBP (MRG Domain Binding Protein) is a Protein Coding gene. Among its related pathways are Chromatin organization.

UniProtKB/Swiss-Prot for MRGBP Gene

  • Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGBP Gene

Genomics for MRGBP Gene

Regulatory Elements for MRGBP Gene

Enhancers for MRGBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F062803 1.1 ENCODE 15 +9.1 9116 3.7 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 LINC00029 LOC105372725 OGFR LINC01056 MRGBP CABLES2 OGFR-AS1
GH20F062715 1.3 Ensembl ENCODE 11 -80.0 -80044 1.0 L3MBTL2 MAFK MGA OGFR-AS1 OGFR LINC00659 SLCO4A1-AS1 SLCO4A1 MIR133A2 MRGBP ENSG00000229882 ENSG00000232121 NTSR1
GH20F062708 1 Ensembl ENCODE 10.9 -85.5 -85527 4.3 ATF1 CBX3 PKNOX1 KLF17 SIN3A GLIS2 SCRT2 CREM REST CREB3 RTEL1 ARFGAP1 TNFRSF6B ENSG00000223669 OGFR OGFR-AS1 SLCO4A1-AS1 SLCO4A1 MRGBP MIR133A2
GH20F062793 1 FANTOM5 ENCODE 10.7 -0.6 -628 5.0 HDGF ARNT MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 SLC30A9 ZNF207 OGFR MIR4758 MRGBP RTEL1 DIDO1 DPH3P1 LOC105372716
GH20F062860 0.8 ENCODE 9.9 +65.2 65224 2.9 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 LINC00029 LOC105372725 TCFL5 LINC01056 TNFRSF6B CABLES2 MRGBP LOC105372717
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MRGBP on UCSC Golden Path with GeneCards custom track

Promoters for MRGBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001450360 -753 3401 HDGF ARNT MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF143 FOS SP3

Genomic Location for MRGBP Gene

Chromosome:
20
Start:
62,796,453 bp from pter
End:
62,801,738 bp from pter
Size:
5,286 bases
Orientation:
Plus strand

Genomic View for MRGBP Gene

Genes around MRGBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGBP Gene

Proteins for MRGBP Gene

  • Protein details for MRGBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV56-MRGBP_HUMAN
    Recommended name:
    MRG/MORF4L-binding protein
    Protein Accession:
    Q9NV56
    Secondary Accessions:
    • A8C4L5

    Protein attributes for MRGBP Gene

    Size:
    204 amino acids
    Molecular mass:
    22417 Da
    Quaternary structure:
    • Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MRGBP may interact directly with MORF4L1/MRG15 and MORF4L2/MRGX.

    Three dimensional structures from OCA and Proteopedia for MRGBP Gene

neXtProt entry for MRGBP Gene

Post-translational modifications for MRGBP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRGBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRGBP Gene

Domains & Families for MRGBP Gene

Protein Domains for MRGBP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MRGBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NV56

UniProtKB/Swiss-Prot:

MRGBP_HUMAN :
  • Belongs to the EAF7 family.
Family:
  • Belongs to the EAF7 family.
genes like me logo Genes that share domains with MRGBP: view

No data available for Gene Families for MRGBP Gene

Function for MRGBP Gene

Molecular function for MRGBP Gene

UniProtKB/Swiss-Prot Function:
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

Gene Ontology (GO) - Molecular Function for MRGBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12963728
genes like me logo Genes that share ontologies with MRGBP: view
genes like me logo Genes that share phenotypes with MRGBP: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MRGBP

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRGBP Gene

Localization for MRGBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGBP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRGBP Gene COMPARTMENTS Subcellular localization image for MRGBP gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MRGBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0035267 NuA4 histone acetyltransferase complex IBA --
GO:0043189 H4/H2A histone acetyltransferase complex IEA --
genes like me logo Genes that share ontologies with MRGBP: view

Pathways & Interactions for MRGBP Gene

genes like me logo Genes that share pathways with MRGBP: view

Pathways by source for MRGBP Gene

Gene Ontology (GO) - Biological Process for MRGBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0016569 covalent chromatin modification IEA --
GO:0016573 histone acetylation IBA --
genes like me logo Genes that share ontologies with MRGBP: view

No data available for SIGNOR curated interactions for MRGBP Gene

Transcripts for MRGBP Gene

mRNA/cDNA for MRGBP Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(184) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGBP Gene

MRG/MORF4L binding protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MRGBP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRGBP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - -
SP7: - -
SP8:
SP9:

Relevant External Links for MRGBP Gene

GeneLoc Exon Structure for
MRGBP
ECgene alternative splicing isoforms for
MRGBP

Expression for MRGBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRGBP Gene

mRNA differential expression in normal tissues according to GTEx for MRGBP Gene

This gene is overexpressed in Testis (x6.1).

Protein differential expression in normal tissues from HIPED for MRGBP Gene

This gene is overexpressed in Breast (35.0), Peripheral blood mononuclear cells (9.0), and Testis (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRGBP Gene



Protein tissue co-expression partners for MRGBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRGBP Gene:

MRGBP

SOURCE GeneReport for Unigene cluster for MRGBP Gene:

Hs.590870
genes like me logo Genes that share expression patterns with MRGBP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MRGBP Gene

Orthologs for MRGBP Gene

This gene was present in the common ancestor of animals.

Orthologs for MRGBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRGBP 34 35
  • 94.95 (n)
cow
(Bos Taurus)
Mammalia C13H20orf20 34 35
  • 91.94 (n)
mouse
(Mus musculus)
Mammalia Mrgbp 34 16 35
  • 91.4 (n)
dog
(Canis familiaris)
Mammalia MRGBP 34 35
  • 91.09 (n)
rat
(Rattus norvegicus)
Mammalia Mrgbp 34
  • 90.68 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 78 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MRGBP 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves C20ORF20 34
  • 79.37 (n)
MRGBP 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRGBP 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3953 34
zebrafish
(Danio rerio)
Actinopterygii mrgbp 34 35
  • 67.4 (n)
zgc73167 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012361 34
  • 48.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta MrgBP 34 35
  • 48.19 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToOne
Species where no ortholog for MRGBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRGBP Gene

ENSEMBL:
Gene Tree for MRGBP (if available)
TreeFam:
Gene Tree for MRGBP (if available)

Paralogs for MRGBP Gene

No data available for Paralogs for MRGBP Gene

Variants for MRGBP Gene

Sequence variations from dbSNP and Humsavar for MRGBP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1060961 -- 62,800,846(-) GGAAG(A/G)AGCCC nc-transcript-variant, utr-variant-3-prime
rs111671968 -- 62,800,560(+) TTCGT(A/G)TGACT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs112218096 -- 62,799,098(+) GCACC(C/T)CAAGA intron-variant
rs112823118 -- 62,795,141(+) CCCCA(G/T)CCCGG upstream-variant-2KB
rs112877465 -- 62,797,795(+) ACGGG(C/G/T)GAGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRGBP Gene

Variant ID Type Subtype PubMed ID
nsv1072133 CNV deletion 25765185
nsv1136334 CNV deletion 24896259
nsv428380 CNV loss 18775914
nsv459065 CNV gain 19166990
nsv470558 CNV loss 18288195
nsv586496 CNV gain 21841781
nsv828792 CNV loss 20364138
nsv828793 CNV gain 20364138
nsv834027 CNV loss 17160897
nsv953302 CNV deletion 24416366
nsv9825 CNV gain 18304495

Variation tolerance for MRGBP Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRGBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRGBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRGBP Gene

Disorders for MRGBP Gene

Relevant External Links for MRGBP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRGBP

No disorders were found for MRGBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGBP Gene

Publications for MRGBP Gene

  1. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PMID: 12963728) Cai Y. … Conaway J.W. (J. Biol. Chem. 2003) 2 3 4 64
  2. Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain. (PMID: 16407074) Bowman B.R. … Quiocho F.A. (Structure 2006) 3 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64

Products for MRGBP Gene

Sources for MRGBP Gene

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