Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MRGBP Gene

protein-coding   GIFtS: 45
GCID: GC20P061428

MRG/MORF4L Binding Protein

(Previous name: chromosome 20 open reading frame 20)
(Previous symbol: C20orf20)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
MRG/MORF4L Binding Protein1 2     MRG15BP2
C20orf201 2 3 5     URCC42
Up-Regulated In Colon Cancer 42 3     MRG(MORF4-Related Gene)-Binding Protein2
MRG-Binding Protein2 3     MRG/MORF4L-Binding Protein2
Chromosome 20 Open Reading Frame 201     Urcc43
Eaf72     

External Ids:    HGNC: 158661   Entrez Gene: 552572   Ensembl: ENSG000001011897   OMIM: 6111575   UniProtKB: Q9NV563   

Export aliases for MRGBP gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for MRGBP Gene:
MRGBP (MRG/MORF4L binding protein) is a protein-coding gene. Diseases associated with MRGBP include pancreatic cancer, and malaria.

UniProtKB/Swiss-Prot: MRGBP_HUMAN, Q9NV56
Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional
activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may
both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins
which positively regulate transcription. This complex may be required for the activation of transcriptional
programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth
arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when
recruited to sites of DNA damage




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MRGBP
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MRGBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRGBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

MRGBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRGBP gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P061428:  view genomic region     (about GC identifiers)

Start:
61,427,805 bp from pter      End:
61,431,945 bp from pter
Size:
4,141 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MRGBP_HUMAN, Q9NV56 (See protein sequence)
Recommended Name: MRG/MORF4L-binding protein  
Size: 204 amino acids; 22417 Da
Subunit: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60
and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin,
ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts
with MYC and the adenovirus E1A protein. MRGBP may interact directly with MORF4L1/MRG15 and MORF4L2/MRGX
Secondary accessions: A8C4L5

Explore the universe of human proteins at neXtProt for MRGBP: NX_Q9NV56

Explore proteomics data for MRGBP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MRGBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060740.1  
    ENSEMBL proteins: 
     ENSP00000359518  
    Reactome Protein details: Q9NV56

    MRGBP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MRGBP
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MRGBP
    GenScript Custom Purified and Recombinant Proteins Services for MRGBP
    Novus Biologicals MRGBP Protein
    Novus Biologicals MRGBP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MRGBP

    MRGBP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MRGBP
    OriGene Custom Antibody Services for MRGBP
    Novus Biologicals MRGBP Antibodies
    Search for Antibodies for MRGBP at Abcam
    Cloud-Clone Corp. Antibodies for MRGBP
    Search ThermoFisher Antibodies for MRGBP
    LSBio Antibodies in human, mouse, rat for MRGBP

    MRGBP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MRGBP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MRGBP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MRGBP
    Cloud-Clone Corp. CLIAs for MRGBP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR012423 Eaf7/MRGBP

    Graphical View of Domain Structure for InterPro Entry Q9NV56

    ProtoNet protein and cluster: Q9NV56

    1 Blocks protein domain: IPB012423 CT20

    UniProtKB/Swiss-Prot: MRGBP_HUMAN, Q9NV56
    Similarity: Belongs to the EAF7 family


    MRGBP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRGBP_HUMAN, Q9NV56
    Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional
    activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may
    both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins
    which positively regulate transcription. This complex may be required for the activation of transcriptional
    programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth
    arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when
    recruited to sites of DNA damage

    Phenotypes:
         1 GenomeRNAi human phenotype for MRGBP:

     Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRGBP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MRGBP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRGBP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MRGBP

    miRNA
    Products:
        
    miRTarBase miRNAs that target MRGBP:
    hsa-mir-503-5p (MIRT041119), hsa-mir-92a-3p (MIRT049387), hsa-mir-101-3p (MIRT027304)

    Block miRNA regulation of human, mouse, rat MRGBP using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MRGBP
    SwitchGear 3'UTR luciferase reporter plasmidMRGBP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MRGBP
    Predesigned siRNA for gene silencing in human, mouse, rat MRGBP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MRGBP

    Clone
    Products:
         
    OriGene clones in human, mouse for MRGBP (see all 6)
    OriGene ORF clones in mouse, rat for MRGBP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MRGBP
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRGBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRGBP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MRGBP
    Browse ESI BIO Cell Lines and PureStem Progenitors for MRGBP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGBP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MRGBP_HUMAN, Q9NV56: Nucleus

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0043189H4/H2A histone acetyltransferase complex IEA--

    MRGBP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MRGBP About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for MRGBP
        HATs acetylate histones



    MRGBP for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRGBP
    Interactions:

        Search GeneGlobe Interaction Network for MRGBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MRGBP (Q9NV563 ENSP000003595184) via UniProtKB, MINT, STRING, and/or I2D (see all 140)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000234258P349313, ENSP000003964864I2D: score=1 STRING: ENSP00000396486
    ENSG00000206383P349313I2D: score=1 
    ENSG00000236251P349313I2D: score=1 
    HSPA1LP349313I2D: score=1 
    DMAP1Q9NPF53, ENSP000003126974I2D: score=4 STRING: ENSP00000312697
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0016568chromatin modification IEA--
    GO:0040008regulation of growth IEA--

    MRGBP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRGBP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MRGBP gene: 
    NM_018270.4  

    Unigene Cluster for MRGBP:

    MRG/MORF4L binding protein
    Hs.590870  [show with all ESTs]
    Unigene Representative Sequence: BC009889
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000370487(uc002ydi.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MRGBP using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MRGBP
    SwitchGear 3'UTR luciferase reporter plasmidMRGBP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MRGBP
    Predesigned siRNA for gene silencing in human, mouse, rat MRGBP
    Clone
    Products:
         
    OriGene clones in human, mouse for MRGBP (see all 6)
    OriGene ORF clones in mouse, rat for MRGBP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MRGBP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRGBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRGBP
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MRGBP
    OriGene qSTAR qPCR primer pairs in human, mouse for MRGBP
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MRGBP
      QuantiTect SYBR Green Assays in human, mouse, rat MRGBP
      QuantiFast Probe-based Assays in human, mouse, rat MRGBP

    Additional mRNA sequence: 

    AB085682.1 AK001776.1 BC009889.2 BC014235.2 BC018841.2 

    6 DOTS entries:

    DT.315782  DT.100793676  DT.91895809  DT.95214571  DT.120821593  DT.97779734 

    Selected AceView cDNA sequences (see all 184):

    BM451009 AI001967 AI200503 AA902150 CA866304 AI498151 BI438841 AI187764 
    AI989723 BM551969 AA307021 AA363921 AA835044 BE277253 BX116603 AA971309 
    CB131787 BU950235 AA149167 BM904739 BF983742 AI022997 BC014235 AA024978 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MRGBP (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
    SP1:                                      -     -                 -     -                                       
    SP2:                    -                 -     -                 -     -                                       
    SP3:                                      -     -                 -                                             
    SP4:                                      -     -     -           -                                             
    SP5:                                      -     -                 -     -     -                                 


    ECgene alternative splicing isoforms for MRGBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MRGBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MRGBP Expression
    About this image

    MRGBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRGBP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.590870
        Custom PCR Arrays for MRGBP
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MRGBP
    OriGene qSTAR qPCR primer pairs in human, mouse for MRGBP
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MRGBP
    QuantiTect SYBR Green Assays in human, mouse, rat MRGBP
    QuantiFast Probe-based Assays in human, mouse, rat MRGBP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MRGBP gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrgbp1 , 5 RIKEN cDNA 1600027N09 gene5
    MRG/MORF4L binding protein1
    91.4(n)1
    97.31(a)1
      2 (103.12 cM)5
    732471  NM_028479.11  NP_082755.11 
     1805827125 
    chicken
    (Gallus gallus)
    Aves C20ORF201 chromosome 20 open reading frame, human C20orf20 79.37(n)
    83.43(a)
      419233  XM_417408.4  XP_417408.2 
    lizard
    (Anolis carolinensis)
    Reptilia MRGBP6
    MRG/MORF4L binding protein
    63(a)
    1 ↔ 1
    4(152389575-152395774)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.39532 Transcribed sequence with weak similarity to protein more 80.32(n)    BQ523447.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731672 hypothetical protein MGC73167 78.42(n)   393709  AY398315.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MrgBP1 MrgBP 48.19(n)
    33.7(a)
      35880  NM_136573.4  NP_610417.1 


    ENSEMBL Gene Tree for MRGBP (if available)
    TreeFam Gene Tree for MRGBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MRGBP (see all 117)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs8569391,2
    C--61425858(+) caccgC/Tccggc 1 -- us2k14Minor allele frequency- T:0.00MN NA 190
    rs736135871,2
    C,F--61425993(+) CTTGCC/TCTTTC 1 -- us2k13Minor allele frequency- T:0.13WA NA EA 358
    rs1920093411,2
    --61426088(+) TAATTA/GTGGGG 1 -- us2k10--------
    rs736135881,2
    C,F--61426293(+) GCCGAG/AGAGGA 1 -- us2k11Minor allele frequency- A:0.25EA 120
    rs1827103091,2
    --61426351(+) GAAACC/TGCGTC 1 -- us2k10--------
    rs119069141,2
    C,F,H--61426404(+) gtagtC/Accagc 1 -- us2k14Minor allele frequency- A:0.22WA CSA 123
    rs1509770801,2
    --61426437(+) GAATCA/GCTTGA 1 -- us2k10--------
    rs1440641631,2
    C--61426513(+) CGAGA-/CTCTGCC 1 -- us2k10--------
    rs758179081,2
    C,F--61426678(+) TTCGTG/ATCTGA 1 -- us2k13Minor allele frequency- A:0.13NA WA 240
    rs60113801,2
    C,F,A,H--61427085(+) ATTCTC/AGTTTC 1 -- us2k120Minor allele frequency- A:0.44NS EA NA WA CSA 2345

    HapMap Linkage Disequilibrium report for MRGBP (61427805 - 61431945 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MRGBP: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRGBP
    DNA2.0 Custom Variant and Variant Library Synthesis for MRGBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611157    OMIM disorders: --

    5 diseases for MRGBP:    
    About MalaCards
    pancreatic cancer    malaria    colorectal cancer    pancreatitis
    squamous cell carcinoma


    MRGBP for disorders           About GeneDecksing


    Export disorders for MRGBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MRGBP gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with MRGBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PubMed id 12963728)1, 2, 3 Cai Y.... Conaway J.W. (J. Biol. Chem. 2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain. (PubMed id 16407074)1, 9 Bowman B.R.... Quiocho F.A. (Structure 2006)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization. (PubMed id 22467210)1 BAPnisch C....Hake S.B. (Nucleic Acids Res. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma. (PubMed id 21602893)1 Watt S.A....South A.P. (Oncogene 2011)
    10. MRG-binding protein contributes to colorectal cancer development. (PubMed id 21535316)1 Yamaguchi K....Furukawa Y. (Cancer Sci. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55257 HGNC: 15866 AceView: C20orf20 Ensembl:ENSG00000101189 euGenes: HUgn55257
    ECgene: MRGBP H-InvDB: MRGBP

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MRGBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MRGBP gene:
    Search GeneIP for patents involving MRGBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MRGBP   OriGene RNAi products in human, mouse, rat for MRGBP  
     OriGene qPCR primer pairs and template standards for MRGBP   OriGene Protein Over-expression Lysate for MRGBP  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MRGBP  
     OriGene qSTAR qPCR primer pairs in human, mouse for MRGBP   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MRGBP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MRGBP   OriGene Custom Protein Services for MRGBP  

     
     
     Block miRNA regulation of human, mouse, rat MRGBP using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MRGBP
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRGBP Predesigned siRNA for gene silencing in human, mouse, rat MRGBP
     QuantiFast Probe-based Assays in human, mouse, rat MRGBP QuantiTect SYBR Green Assays in human, mouse, rat MRGBP
     Custom PCR Arrays for MRGBP Search Chromatin IP Primers for MRGBP
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MRGBP Search GeneGlobe Interaction Network for MRGBP
     Search Regulatory tfbs for MRGBP
     GenScript Custom Purified and Recombinant Proteins Services for MRGBP GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for MRGBP
     GenScript Custom Assay Services for MRGBP GenScript Custom overexpressing Cell Line Services for MRGBP
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MRGBP
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MRGBP antibodies
     MRGBP proteins
     MRGBP lysates
     Search for Antibodies for MRGBP at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MRGBP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MRGBP
     Antibodies for MRGBP
     ELISAs for MRGBP
     CLIAs for MRGBP



     Browse ESI BIO Cell Lines and PureStem Progenitors for MRGBP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGBP
     SwitchGear 3'UTR luciferase reporter plasmids for MRGBP
     Browse SwitchGear Promoter luciferase reporter plasmids for MRGBP
     Search ThermoFisher Antibodies for MRGBP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRGBP
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRGBP
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MRGBP
     LSBio Antibodies in human, mouse, rat for MRGBP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MRGBP gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4