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Aliases for MRFAP1L1 Gene

Aliases for MRFAP1L1 Gene

  • Morf4 Family Associated Protein 1 Like 1 2 3 5
  • MORF4 Family-Associated Protein 1-Like 1 3
  • PP784 3

External Ids for MRFAP1L1 Gene

Previous GeneCards Identifiers for MRFAP1L1 Gene

  • GC04M006828
  • GC04M006709
  • GC04M006641

Summaries for MRFAP1L1 Gene

GeneCards Summary for MRFAP1L1 Gene

MRFAP1L1 (Morf4 Family Associated Protein 1 Like 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding. An important paralog of this gene is MRFAP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRFAP1L1 Gene

Genomics for MRFAP1L1 Gene

Regulatory Elements for MRFAP1L1 Gene

Enhancers for MRFAP1L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F006708 1.1 ENCODE 19 +0.5 464 2.8 ATF1 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A ZNF48 ETS1 YY1 MRFAP1L1 S100P LOC93622 ENSG00000282742
GH04F006891 1.7 FANTOM5 Ensembl ENCODE 11.6 -183.3 -183278 3.9 PKNOX1 MLX CREB3L1 SIN3A ARID4B DMAP1 YY1 SLC30A9 ZNF766 CBX5 BLOC1S4 MRFAP1L1 TBC1D14 LOC93622 KIAA0232 TADA2B PIR60819 GC04P006857
GH04F006767 1.3 Ensembl ENCODE 11.6 -61.2 -61205 7.6 PKNOX1 ARID4B DMAP1 YY1 ZNF121 FOS SP5 NFYC PPARG KAT8 BLOC1S4 MRFAP1L1 GC04P006772 LOC105374367
GH04F006855 1.2 Ensembl ENCODE 11.7 -146.1 -146104 2.0 PKNOX1 FOS JUNB TBX21 ZNF264 MEF2D MAFF SMARCA4 NBN ASH2L BLOC1S4 LOC105374366 LOC93622 KIAA0232 MRFAP1L1 GC04P006857 GC04P006842
GH04F006672 1.1 ENCODE 11.9 +35.4 35371 3.1 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 LOC105374366 BLOC1S4 LOC93622 MRFAP1L1 KIAA0232 S100P LOC339988
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRFAP1L1 on UCSC Golden Path with GeneCards custom track

Promoters for MRFAP1L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001235815 380 2601 ATF1 PKNOX1 WRNIP1 ARID4B SIN3A ZNF48 ETS1 YY1 ZNF766 ZNF143

Genomic Location for MRFAP1L1 Gene

Chromosome:
4
Start:
6,707,701 bp from pter
End:
6,709,880 bp from pter
Size:
2,180 bases
Orientation:
Minus strand

Genomic View for MRFAP1L1 Gene

Genes around MRFAP1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRFAP1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRFAP1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRFAP1L1 Gene

Proteins for MRFAP1L1 Gene

  • Protein details for MRFAP1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HT8-MR1L1_HUMAN
    Recommended name:
    MORF4 family-associated protein 1-like 1
    Protein Accession:
    Q96HT8
    Secondary Accessions:
    • B2R6R0
    • Q6NXT8
    • Q9P0J5

    Protein attributes for MRFAP1L1 Gene

    Size:
    127 amino acids
    Molecular mass:
    14808 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF67011.1; Type=Frameshift; Positions=89; Evidence={ECO:0000305};

neXtProt entry for MRFAP1L1 Gene

Post-translational modifications for MRFAP1L1 Gene

  • Ubiquitination at Lys 99
  • Modification sites at PhosphoSitePlus

Other Protein References for MRFAP1L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRFAP1L1 Gene

Domains & Families for MRFAP1L1 Gene

Protein Domains for MRFAP1L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRFAP1L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96HT8

UniProtKB/Swiss-Prot:

MR1L1_HUMAN :
  • Belongs to the MORF4 family-associated protein family.
Family:
  • Belongs to the MORF4 family-associated protein family.
genes like me logo Genes that share domains with MRFAP1L1: view

No data available for Gene Families for MRFAP1L1 Gene

Function for MRFAP1L1 Gene

Gene Ontology (GO) - Molecular Function for MRFAP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with MRFAP1L1: view
genes like me logo Genes that share phenotypes with MRFAP1L1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRFAP1L1 Gene

Localization for MRFAP1L1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRFAP1L1 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MRFAP1L1 Gene

Pathways & Interactions for MRFAP1L1 Gene

SuperPathways for MRFAP1L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRFAP1L1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MRFAP1L1 Gene

Transcripts for MRFAP1L1 Gene

mRNA/cDNA for MRFAP1L1 Gene

Unigene Clusters for MRFAP1L1 Gene

Morf4 family associated protein 1-like 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRFAP1L1 Gene

ExUns: 1a · 1b ^ 2
SP1:
SP2:

Relevant External Links for MRFAP1L1 Gene

GeneLoc Exon Structure for
MRFAP1L1
ECgene alternative splicing isoforms for
MRFAP1L1

Expression for MRFAP1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRFAP1L1 Gene

Protein differential expression in normal tissues from HIPED for MRFAP1L1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MRFAP1L1 Gene



Protein tissue co-expression partners for MRFAP1L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRFAP1L1 Gene:

MRFAP1L1

SOURCE GeneReport for Unigene cluster for MRFAP1L1 Gene:

Hs.593159
genes like me logo Genes that share expression patterns with MRFAP1L1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRFAP1L1 Gene

Orthologs for MRFAP1L1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MRFAP1L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRFAP1L1 34 35
  • 99.74 (n)
Species where no ortholog for MRFAP1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRFAP1L1 Gene

ENSEMBL:
Gene Tree for MRFAP1L1 (if available)
TreeFam:
Gene Tree for MRFAP1L1 (if available)

Paralogs for MRFAP1L1 Gene

Paralogs for MRFAP1L1 Gene

(1) SIMAP similar genes for MRFAP1L1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MRFAP1L1 Gene

genes like me logo Genes that share paralogs with MRFAP1L1: view

Variants for MRFAP1L1 Gene

Sequence variations from dbSNP and Humsavar for MRFAP1L1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10937751 -- 6,710,329(+) GGAAC(A/C)CGTCC intron-variant, upstream-variant-2KB
rs111830025 -- 6,711,829(+) GAGTG(C/T)AATTG intron-variant, upstream-variant-2KB
rs115864063 -- 6,709,920(+) CCGGG(C/T)CCCTT upstream-variant-2KB
rs11726798 -- 6,707,220(+) GAACT(C/G)GAAAG downstream-variant-500B
rs12648464 -- 6,711,698(+) gcaca(G/T)aataa intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRFAP1L1 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER inversion 12058347
nsv1073726 CNV deletion 25765185

Variation tolerance for MRFAP1L1 Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRFAP1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRFAP1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRFAP1L1 Gene

Disorders for MRFAP1L1 Gene

Relevant External Links for MRFAP1L1

Genetic Association Database (GAD)
MRFAP1L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRFAP1L1

No disorders were found for MRFAP1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRFAP1L1 Gene

Publications for MRFAP1L1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N. … Roth F.P. (Mol. Syst. Biol. 2016) 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for MRFAP1L1 Gene

Sources for MRFAP1L1 Gene

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