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Aliases for MRFAP1L1 Gene

Aliases for MRFAP1L1 Gene

  • Morf4 Family Associated Protein 1 Like 1 2 3 5
  • MORF4 Family-Associated Protein 1-Like 1 3
  • PP784 3

External Ids for MRFAP1L1 Gene

Previous GeneCards Identifiers for MRFAP1L1 Gene

  • GC04M006828
  • GC04M006709
  • GC04M006641

Summaries for MRFAP1L1 Gene

GeneCards Summary for MRFAP1L1 Gene

MRFAP1L1 (Morf4 Family Associated Protein 1 Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is MRFAP1.

Additional gene information for MRFAP1L1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRFAP1L1 Gene

Genomics for MRFAP1L1 Gene

GeneHancer (GH) Regulatory Elements for MRFAP1L1 Gene

Promoters and enhancers for MRFAP1L1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I006708 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 569 +0.5 463 2.8 PKNOX1 SMAD1 ARNT ARID4B SIN3A YY1 POLR2B ZNF766 E2F8 ZNF143 MRFAP1L1 BLOC1S4 S100P LOC93622 ENSG00000282742 GC04P006621
GH04I006672 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 11.9 +35.4 35371 3.1 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 LINC02482 LOC93622 BLOC1S4 MRFAP1L1 KIAA0232 S100P LINC002481 GC04P006638 GC04P006634 GC04P006621
GH04I006891 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -183.4 -183366 3.7 PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 ZNF766 CBX5 SP5 NFYC BLOC1S4 MRFAP1L1 TBC1D14 LOC93622 KIAA0232 TADA2B PIR60819 GC04P006857
GH04I006767 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.6 -61.2 -61204 7.6 PKNOX1 FOXA2 ARID4B DMAP1 YY1 ZNF121 FOS ATF7 RUNX3 RXRA GC04P006772 BLOC1S4 MRFAP1L1 LOC105374367
GH04I006855 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.8 -146.2 -146240 1.7 PKNOX1 ATF1 SMAD1 IRF4 NCOA2 ZNF207 ATF7 FOS RUNX3 JUNB GC04P006857 KIAA0232 LOC93622 LINC02482 MRFAP1L1 BLOC1S4 GC04P006842
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRFAP1L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRFAP1L1 gene promoter:

Genomic Locations for MRFAP1L1 Gene

Genomic Locations for MRFAP1L1 Gene
2,180 bases
Minus strand

Genomic View for MRFAP1L1 Gene

Genes around MRFAP1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRFAP1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRFAP1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRFAP1L1 Gene

Proteins for MRFAP1L1 Gene

  • Protein details for MRFAP1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MORF4 family-associated protein 1-like 1
    Protein Accession:
    Secondary Accessions:
    • B2R6R0
    • Q6NXT8
    • Q9P0J5

    Protein attributes for MRFAP1L1 Gene

    127 amino acids
    Molecular mass:
    14808 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF67011.1; Type=Frameshift; Positions=89; Evidence={ECO:0000305};

neXtProt entry for MRFAP1L1 Gene

Post-translational modifications for MRFAP1L1 Gene

Other Protein References for MRFAP1L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRFAP1L1 Gene

Domains & Families for MRFAP1L1 Gene

Gene Families for MRFAP1L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MRFAP1L1 Gene


Suggested Antigen Peptide Sequences for MRFAP1L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MORF4 family-associated protein family.
  • Belongs to the MORF4 family-associated protein family.
genes like me logo Genes that share domains with MRFAP1L1: view

Function for MRFAP1L1 Gene

Gene Ontology (GO) - Molecular Function for MRFAP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with MRFAP1L1: view
genes like me logo Genes that share phenotypes with MRFAP1L1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRFAP1L1 Gene

Localization for MRFAP1L1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRFAP1L1 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MRFAP1L1 Gene

Pathways & Interactions for MRFAP1L1 Gene

SuperPathways for MRFAP1L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRFAP1L1 Gene


No data available for Pathways by source and SIGNOR curated interactions for MRFAP1L1 Gene

Drugs & Compounds for MRFAP1L1 Gene

No Compound Related Data Available

Transcripts for MRFAP1L1 Gene

mRNA/cDNA for MRFAP1L1 Gene

Unigene Clusters for MRFAP1L1 Gene

Morf4 family associated protein 1-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRFAP1L1 Gene

ExUns: 1a · 1b ^ 2

Relevant External Links for MRFAP1L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRFAP1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRFAP1L1 Gene

Protein differential expression in normal tissues from HIPED for MRFAP1L1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MRFAP1L1 Gene

Protein tissue co-expression partners for MRFAP1L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRFAP1L1 Gene:


SOURCE GeneReport for Unigene cluster for MRFAP1L1 Gene:


Evidence on tissue expression from TISSUES for MRFAP1L1 Gene

  • Nervous system(4.9)
  • Adrenal gland(4.3)
  • Heart(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with MRFAP1L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRFAP1L1 Gene

Orthologs for MRFAP1L1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MRFAP1L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRFAP1L1 33 34
  • 99.74 (n)
Species where no ortholog for MRFAP1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRFAP1L1 Gene

Gene Tree for MRFAP1L1 (if available)
Gene Tree for MRFAP1L1 (if available)

Paralogs for MRFAP1L1 Gene

Paralogs for MRFAP1L1 Gene

(1) SIMAP similar genes for MRFAP1L1 Gene using alignment to 1 proteins: Pseudogenes for MRFAP1L1 Gene

genes like me logo Genes that share paralogs with MRFAP1L1: view

Variants for MRFAP1L1 Gene

Sequence variations from dbSNP and Humsavar for MRFAP1L1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000413906 -- 6,707,635(-) C/A downstream_transcript_variant
rs1000612794 -- 6,708,736(-) A/G intron_variant
rs1000771655 -- 6,709,020(-) G/T intron_variant
rs1000990603 -- 6,708,899(-) A/C intron_variant
rs1001167363 -- 6,707,738(-) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for MRFAP1L1 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER inversion 12058347
nsv1073726 CNV deletion 25765185

Variation tolerance for MRFAP1L1 Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRFAP1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRFAP1L1 Gene

Disorders for MRFAP1L1 Gene

Additional Disease Information for MRFAP1L1

No disorders were found for MRFAP1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRFAP1L1 Gene

Publications for MRFAP1L1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N … Roth FP (Molecular systems biology 2016) 3 58
  4. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for MRFAP1L1 Gene

Sources for MRFAP1L1 Gene

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