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MRFAP1 Gene

protein-coding   GIFtS: 50
GCID: GC04P006573

Morf4 Family Associated Protein 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Morf4 Family Associated Protein 11 2     Mof4 Family Associated Protein 12
Protein Associated With MRG Of 14 KDa2 3     MORF4 Family-Associated Protein 12
PAM142 3     T-Cell Activation Protein2
PGR12 3     Protein PGR13

External Ids:    HGNC: 245491   Entrez Gene: 936212   Ensembl: ENSG000001790107   UniProtKB: Q9Y6053   

Export aliases for MRFAP1 gene to outside databases

Previous GC identifers: GC04P006761 GC04P006692 GC04P006643


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRFAP1 Gene:
This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on
chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may
play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Jan 2013)

GeneCards Summary for MRFAP1 Gene:
MRFAP1 (Morf4 family associated protein 1) is a protein-coding gene. Diseases associated with MRFAP1 include cervix uteri carcinoma in situ, and retinoblastoma. An important paralog of this gene is MRFAP1L1.

Gene Wiki entry for MRFAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_006051.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRFAP1 gene promoter:
         SRF   SRF (504 AA)   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   CBF-A   POU2F1   POU2F1a   HFH-1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRFAP1 promoter sequence
   Search Chromatin IP Primers for MRFAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRFAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

MRFAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRFAP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P006573:  view genomic region     (about GC identifiers)

Start:
6,641,818 bp from pter      End:
6,644,472 bp from pter
Size:
2,655 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MOFA1_HUMAN, Q9Y605 (See protein sequence)
Recommended Name: MORF4 family-associated protein 1  
Size: 127 amino acids; 14650 Da
Subunit: Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1.
Interacts with CSTB and MORF4L2
Secondary accessions: B3KVT2 D3DVT3

Explore the universe of human proteins at neXtProt for MRFAP1: NX_Q9Y605

Explore proteomics data for MRFAP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys56
  • Modification sites at PhosphoSitePlus

  • See MRFAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258982.1  NP_001258983.1  NP_150638.1  

    ENSEMBL proteins: 
     ENSP00000318352   ENSP00000422065   ENSP00000372024  

    MRFAP1 Human Recombinant Protein Products:

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    Novus Biologicals MRFAP1 Lysate
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    Cloud-Clone Corp. Proteins for MRFAP1

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    LSBio Antibodies in human, mouse, rat for MRFAP1

    MRFAP1 Assay Products:

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    Cloud-Clone Corp. ELISAs for MRFAP1
    Cloud-Clone Corp. CLIAs for MRFAP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9Y605

    UniProtKB/Swiss-Prot: MOFA1_HUMAN, Q9Y605
    Similarity: Belongs to the MORF4 family-associated protein family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11500496
         
    MRFAP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mrfap1):
     immune system  normal 

    MRFAP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mrfap1tm1Kto for MRFAP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRFAP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRFAP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MRFAP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MRFAP1:
    hsa-mir-328-3p (MIRT043774), hsa-mir-1 (MIRT023865), hsa-mir-186-5p (MIRT045034), hsa-mir-16-5p (MIRT031820), hsa-mir-423-3p (MIRT042574), hsa-mir-615-3p (MIRT039701)

    Block miRNA regulation of human, mouse, rat MRFAP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MRFAP1 (see all 21):
    hsa-miR-320a hsa-miR-142-3p hsa-miR-134 hsa-miR-342-3p hsa-miR-29b-1* hsa-miR-373* hsa-miR-570 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidMRFAP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MRFAP1
    Predesigned siRNA for gene silencing in human, mouse, rat MRFAP1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MRFAP1

    Clone
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    OriGene clones in human, mouse for MRFAP1 (see all 7)
    OriGene ORF clones in mouse, rat for MRFAP1
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    GenScript: all cDNA clones in your preferred vector: MRFAP1 (NM_033296)
    Sino Biological Human cDNA Clone for MRFAP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRFAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRFAP1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRFAP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MOFA1_HUMAN, Q9Y605: Nucleus. Cytoplasm, perinuclear region. Note=Colocalizes with MORF4L1 to cell nuclei
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    MRFAP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRFAP1
    Interactions:

        GeneGlobe Interaction Network for MRFAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for MRFAP1 (Q9Y6051, 2, 3 ENSP000003183524) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C8orf33Q9H7E92, 3MINT-8250468 I2D: score=2 
    MAP1LC3BQ9GZQ82, 3MINT-8259693 I2D: score=2 
    PAM16Q9Y3D72, 3MINT-8259412 I2D: score=2 
    TK1P041832, 3MINT-8273752 I2D: score=2 
    CACNA1BQ009753, ENSP000002775494I2D: score=1 STRING: ENSP00000277549
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRFAP1 (MOFA1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MRFAP1 gene (3 alternative transcripts): 
    NM_001272053.1  NM_001272054.1  NM_033296.2  

    Unigene Cluster for MRFAP1:

    Morf4 family associated protein 1
    Hs.406590  [show with all ESTs]
    Unigene Representative Sequence: NM_033296
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000320912(uc003gjg.1) ENST00000507420 ENST00000382581(uc003gjh.1)
    ENST00000512914(uc021xla.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MRFAP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MRFAP1 (see all 21):
    hsa-miR-320a hsa-miR-142-3p hsa-miR-134 hsa-miR-342-3p hsa-miR-29b-1* hsa-miR-373* hsa-miR-570 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidMRFAP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MRFAP1
    Predesigned siRNA for gene silencing in human, mouse, rat MRFAP1
    Clone
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    OriGene clones in human, mouse for MRFAP1 (see all 7)
    OriGene ORF clones in mouse, rat for MRFAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MRFAP1 (NM_033296)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRFAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRFAP1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MRFAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for MRFAP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRFAP1
      QuantiTect SYBR Green Assays in human, mouse, rat MRFAP1
      QuantiFast Probe-based Assays in human, mouse, rat MRFAP1

    Additional mRNA sequence: 

    AK057736.1 AK074496.1 AK123360.1 AK129651.1 AK300242.1 AK303974.1 BC022797.1 CR457144.1 

    23 DOTS entries:

    DT.97791252  DT.211720  DT.100855508  DT.100687506  DT.100672233  DT.100855010  DT.92469254  DT.102833531 
    DT.100687515  DT.121243303  DT.100038649  DT.92469220  DT.121243255  DT.121243250  DT.95189941  DT.95371140 
    DT.100687510  DT.121243246  DT.121243287  DT.95371142  DT.100687508  DT.91959457  DT.95371130 

    Selected AceView cDNA sequences (see all 602):

    BU153743 CB156454 CR614780 BM450808 CR614739 BG287807 BE887341 AW748264 
    BQ109211 CR616052 CR624612 CB136654 BQ932388 CR611057 AW055283 CR614661 
    AW305286 BQ883539 BG110531 AL540313 BI858568 CR620538 BM716660 BP346799 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MRFAP1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
    SP1:              -                                                               
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                -     -                                       
    SP5:                                                                              


    ECgene alternative splicing isoforms for MRFAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRFAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MRFAP1 Expression
    About this image


    MRFAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Intermediate Mesoderm
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    MRFAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRFAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406590
        Custom PCR Arrays for MRFAP1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRFAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for MRFAP1 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrfap11 , 5 Morf4 family associated protein 11, 5 86.4(n)1
    86.4(a)1
      5 (19.26 cM)5
    675681  NM_026242.31  NP_080518.11 
     367948675 


    ENSEMBL Gene Tree for MRFAP1 (if available)
    TreeFam Gene Tree for MRFAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MRFAP1 gene
    MRFAP1L12  
    1 SIMAP similar gene for MRFAP1 using alignment to 1 protein entry:     MOFA1_HUMAN:
    MRFAP1L1

    MRFAP1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MRFAP1
    PGOHUM00000260999


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MRFAP1 (see all 146)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1816144301,2
    --6639864(+) ACCGCA/CTGTTC 3 -- us2k10--------
    rs1842247951,2
    --6639945(+) GTTGTA/GGGGTG 3 -- us2k10--------
    rs1888886291,2
    --6639958(+) GGGAGG/TGGGGA 3 -- us2k10--------
    rs1819616171,2
    --6640146(+) ATTTTA/GCCAAG 3 -- us2k10--------
    rs1871634951,2
    --6640228(+) GCTTAC/GTTTTA 3 -- us2k10--------
    rs802168761,2
    C--6640302(+) AGAGGT/CGGGAC 3 -- us2k12Minor allele frequency- C:0.25NA 4
    rs1911817931,2
    --6640419(+) CATCTA/GTCTCA 3 -- us2k10--------
    rs1807084541,2
    --6640528(+) AGGAAC/TAGAAT 3 -- us2k10--------
    rs1865652891,2
    --6640551(+) TGCCTC/GATGCA 3 -- us2k10--------
    rs1433534161,2
    C--6640573(+) GACTGG/TCCCCT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for MRFAP1 (6641818 - 6644472 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MRFAP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829849CNV Loss17160897
    nsv4215CNV Loss18451855
    esv34196OTHER Inversion12058347

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRFAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for MRFAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for MRFAP1:    
    About MalaCards
    cervix uteri carcinoma in situ    retinoblastoma    prostatitis    prostate cancer


    MRFAP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRFAP1

    Export disorders for MRFAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRFAP1 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with MRFAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14. (PubMed id 17008723)1, 2 Zhang P.... Ding J. (Protein Sci. 2006)
    2. PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice. (PubMed id 15367658)1, 3 Tominaga K....Pereira-Smith O.M. (Mol. Cell. Biol. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. (PubMed id 14506250)1, 2 Tominaga K....Pereira-Smith O.M. (J. Biol. Chem. 2003)
    5. MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. (PubMed id 12397079)1, 2 Pardo P.S.... Pereira-Smith O.M. (J. Biol. Chem. 2002)
    6. MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14. (PubMed id 11500496)1, 2 Leung J.K....Pereira-Smith O.M. (J. Biol. Chem. 2001)
    7. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    8. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    9. Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway. (PubMed id 22038470)1 Larance M....Lamond A.I. (amp 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 93621 HGNC: 24549 AceView: PGR1 Ensembl:ENSG00000179010 euGenes: HUgn93621
    ECgene: MRFAP1 H-InvDB: MRFAP1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRFAP1 Pharmacogenomics, SNPs, Pathways

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