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MREG Gene

protein-coding   GIFtS: 47
GCID: GC02M216807

Melanoregulin

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disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
melanoregulin1 2
DSU2 3 5
Dilute Suppressor Protein Homolog2 3
WDT22
Whn-Dependent Transcript 22

External Ids:    HGNC: 254781   Entrez Gene: 556862   Ensembl: ENSG000001182427   OMIM: 6092075   UniProtKB: Q8N5653   

Export aliases for MREG gene to outside databases

Previous GC identifers: GC02M216516 GC02M208664


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MREG Gene:
MREG (melanoregulin) is a protein-coding gene.

UniProtKB/Swiss-Prot: MREG_HUMAN, Q8N565
Function: Plays a role in the incorporation of pigments into hair. May function in membrane fusion and regulate
the biogenesis of disk membranes of photoreceptor rod cells (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the MREG gene promoter:
         AML1a   NF-kappaB   NF-AT   C/EBPalpha   RORalpha1   c-Rel   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMREG promoter sequence
   Search Chromatin IP Primers for MREG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MREG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

MREG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MREG gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M216807:  view genomic region     (about GC identifiers)

Start:
216,807,314 bp from pter      End:
216,898,819 bp from pter
Size:
91,506 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MREG_HUMAN, Q8N565 (See protein sequence)
Recommended Name: Melanoregulin  
Size: 214 amino acids; 24927 Da
Subunit: Interacts with PRPH2 (By similarity)
Secondary accessions: Q53R89 Q53TC1 Q5XKB6 Q9NWC9 Q9P1S1
Alternative splicing: 2 isoforms:  Q8N565-1   Q8N565-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MREG: NX_Q8N565

Explore proteomics data for MREG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MREG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060470.2  
    ENSEMBL proteins: 
     ENSP00000263268   ENSP00000411076   ENSP00000413302   ENSP00000404470  

    MREG Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MREG

     
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    antibodies-online proteins for MREG (2 products) 

     
    antibodies-online peptides for MREG

    MREG Antibody Products:

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    antibodies-online antibodies for MREG (34 products) 

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    Cloud-Clone Corp. ELISAs for MREG
    Cloud-Clone Corp. CLIAs for MREG
    Search eBioscience for ELISAs for MREG 
    antibodies-online kits for MREG (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8N565

    UniProtKB/Swiss-Prot: MREG_HUMAN, Q8N565
    Similarity: Belongs to the melanoregulin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MREG_HUMAN, Q8N565
    Function: Plays a role in the incorporation of pigments into hair. May function in membrane fusion and regulate
    the biogenesis of disk membranes of photoreceptor rod cells (By similarity)

    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mreg):

     behavior/neurological  integument  muscle  nervous system  normal 
     pigmentation  vision/eye 

    Find genes that share phenotypes with MREG           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MREG

    miRNA
    Products:
        
    miRTarBase miRNAs that target MREG:
    hsa-mir-19b-3p (MIRT031256), hsa-mir-26b-5p (MIRT030085), hsa-mir-130b-3p (MIRT020312), hsa-mir-375 (MIRT020014)

    Block miRNA regulation of human, mouse, rat MREG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MREG (see all 28):
    hsa-miR-498 hsa-miR-4254 hsa-miR-3607-3p hsa-miR-944 hsa-miR-138-2* hsa-miR-1205 hsa-miR-1297 hsa-miR-378b
    SwitchGear 3'UTR luciferase reporter plasmidMREG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MREG
    Predesigned siRNA for gene silencing in human, mouse, rat MREG

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for MREG (see all 7)
    OriGene ORF clones in mouse, rat for MREG
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    GenScript: all cDNA clones in your preferred vector: MREG (NM_018000)
    Sino Biological Human cDNA Clone for MREG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MREG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MREG

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MREG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MREG_HUMAN, Q8N565: Apical cell membrane; Peripheral membrane protein (By similarity). Note=Localizes to the
    inner segment and basal outer segment of rods in the retina (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytosol1
    lysosome1
    mitochondrion1
    nucleus1
    vacuole1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016324apical plasma membrane IEA--

    Find genes that share ontologies with MREG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MREG
    Interactions:

        Search GeneGlobe Interaction Network for MREG

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for MREG (ENSP000002632684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030318melanocyte differentiation IEA--
    GO:0042640anagen IEA--
    GO:0043473pigmentation ----
    GO:0048066developmental pigmentation ----

    Find genes that share ontologies with MREG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MREG



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MREG gene: 
    NM_018000.2  

    Unigene Cluster for MREG:

    Melanoregulin
    Hs.620391  [show with all ESTs]
    Unigene Representative Sequence: NM_018000
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263268 ENST00000439791 ENST00000424992 ENST00000420348
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MREG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MREG (see all 28):
    hsa-miR-498 hsa-miR-4254 hsa-miR-3607-3p hsa-miR-944 hsa-miR-138-2* hsa-miR-1205 hsa-miR-1297 hsa-miR-378b
    SwitchGear 3'UTR luciferase reporter plasmidMREG 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MREG
    Predesigned siRNA for gene silencing in human, mouse, rat MREG
    Clone
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    OriGene clones in human, mouse for MREG (see all 7)
    OriGene ORF clones in mouse, rat for MREG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MREG (NM_018000)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MREG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MREG
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MREG
    OriGene qSTAR qPCR primer pairs in human, mouse for MREG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MREG
      QuantiTect SYBR Green Assays in human, mouse, rat MREG
      QuantiFast Probe-based Assays in human, mouse, rat MREG

    Additional mRNA sequence: 

    AF068290.1 AK000978.1 

    8 DOTS entries:

    DT.92423943  DT.100812382  DT.95274384  DT.120945432  DT.120945429  DT.92423944  DT.205768  DT.95114238 

    Selected AceView cDNA sequences (see all 70):

    BQ958428 BM692776 CR604344 CB529033 BQ939081 BC032747 BG032393 AW182843 
    AI089810 BE464491 CD370935 AA364072 BQ431470 NM_018000 BG186083 AU118059 
    BX401402 BG388147 BQ943974 CB988857 AI564124 BE349591 AK000978 AI421804 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MREG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATGTAAAA
    MREG Expression
    About this image


    MREG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Somatic Cells Ovigerous Cord
     
     Lung (Respiratory System)
             Basal Cells Trachea
     
     Gonad
             XX Germ Cells Ovigerous Cord
    MREG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MREG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.620391

    UniProtKB/Swiss-Prot: MREG_HUMAN, Q8N565
    Tissue specificity: Expressed in photoreceptor cells (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MREG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MREG gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mreg1 , 5 melanoregulin1, 5 84.42(n)1
    85.98(a)1
      1 (36.39 cM)5
    3812691  NM_001005423.21  NP_001005423.11 
     721592335 
    chicken
    (Gallus gallus)
    Aves MREG1 melanoregulin 73.78(n)
    78.12(a)
      424013  XM_421870.4  XP_421870.3 
    lizard
    (Anolis carolinensis)
    Reptilia MREG6
    melanoregulin
    80(a)
    1 ↔ 1
    1(117149487-117176114)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.168822 Xenopus laevis transcribed sequence with weak similarity more 72.47(n)    BJ068712.1 
    zebrafish
    (Danio rerio)
    Actinopterygii MREG6
    melanoregulin
    37(a)
    1 ↔ 1
    19(5614523-5623435) ENSDARG00000011076


    ENSEMBL Gene Tree for MREG (if available)
    TreeFam Gene Tree for MREG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MREG gene

    Find genes that share paralogs with MREG           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MREG
    PGOHUM00000239393


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MREG (see all 1659)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1858343511,2
    --216806855(+) TTTGAA/TCTACT 1 -- ds50010--------
    rs774711351,2
    F--216806886(+) GTGCAT/CTTTAA 1 -- ds50011Minor allele frequency- C:0.05WA 118
    rs1497689491,2
    C--216806898(+) ATAAAA/TATTAA 1 -- ds50010--------
    rs1457127271,2
    --216806905(+) TTAATA/GTAAAA 1 -- ds50010--------
    rs2008352171,2
    --216806985(+) AATAT-/AAAAAA 1 -- ds50010--------
    rs1903045311,2
    --216807066(+) TTCTGG/TGGCTA 1 -- ds50010--------
    rs130303801,2
    C,F--216807127(+) CCTGCG/ACCCCT 1 -- ds50014Minor allele frequency- A:0.17NA 126
    rs130302431,2
    C,F,H--216807227(+) TTCAGC/TCTCTC 1 -- ds50019Minor allele frequency- T:0.14NS EA NA WA 660
    rs1810928941,2
    --216807258(+) TTATGA/GAAAGA 1 -- ds50010--------
    rs1485212451,2
    --216807316(+) AAGTAA/CATACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MREG (216807314 - 216898819 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MREG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663695CNV Deletion23128226
    dgv759e199CNV Deletion23128226
    nsv3158CNV Insertion18451855
    nsv875842CNV Loss21882294
    nsv525473CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MREG
    DNA2.0 Custom Variant and Variant Library Synthesis for MREG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609207    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for MREG:
    Ocular albinism

    Find genes that share disorders with MREG           About GenesLikeMe

    Genetic Association Database (GAD): MREG
    Human Genome Epidemiology (HuGE) Navigator: MREG (1 document)

    Export disorders for MREG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MREG gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with MREG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes. (PubMed id 22275436)1, 3 Ohbayashi N....Fukuda M. (J. Cell. Sci. 2012)
    2. Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene. (PubMed id 20463177)1, 4 Hersh C.P....Silverman E.K. (Am. J. Respir. Crit. Care Med. 2010)
    3. Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells. (PubMed id 19240024)1, 3 Damek-Poprawa M....Boesze-Battaglia K. (J. Biol. Chem. 2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PubMed id 23720494)1 Evans D.M....Whitfield J.B. (Hum. Mol. Genet. 2013)
    6. Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. (PubMed id 22004471)4 Frank J....Rietschel M. (Addict Biol 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Genome-wide association study of alcohol dependence. (PubMed id 19581569)4 Treutlein J....Rietschel M. (Arch. Gen. Psychiatry 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55686 HGNC: 25478 AceView: FLJ10116 Ensembl:ENSG00000118242 euGenes: HUgn55686
    ECgene: MREG H-InvDB: MREG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MREG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MREG gene:
    Search GeneIP for patents involving MREG

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MREG  
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     Block miRNA regulation of human, mouse, rat MREG using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MREG
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     Browse ESI BIO Cell Lines and PureStem Progenitors for MREG
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     antibodies-online antibodies for MREG (34 products)
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