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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRE11A Gene

protein-coding   GIFtS: 70
GCID: GC11M094150

MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

(Previous name: meiotic recombination (S. cerevisiae) 11 homolog A )
(Previous symbol: MRE11)
 Explore 43 diseases affiliated with
MRE11A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MRE11A    

Aliases
for MRE11A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae)1 2     MRE11 Homolog A2 3
MRE111 2 3 5     Meiotic Recombination (S. Cerevisiae) 11 Homolog A1
ATLD1 2 5     MRE11B2
Meiotic Recombination 11 Homolog 12 3     AT-Like Disease2
Meiotic Recombination 11 Homolog A2 3     DNA Recombination And Repair Protein2
HNGS12 3     Double-Strand Break Repair Protein MRE11A2
MRE11 Homolog 12 3     Endo/Exonuclease Mre112

External Ids:    HGNC: 72301   Entrez Gene: 43612   Ensembl: ENSG000000209227   OMIM: 6008145   UniProtKB: P499593   

Export aliases for MRE11A gene to outside databases

Previous GC identifers: GC11M096483 GC11M095658 GC11M094335 GC11M093838 GC11M093790 GC11M090216


Summaries
for MRE11A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MRE11A:
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA
double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The
protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and
possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA
ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of
the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two
transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MRE11_HUMAN, P49959
Function: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA
recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease
activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to
bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence
homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the
nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required
for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation

Gene Wiki entry for MRE11A


Genomic Views
for MRE11A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRE11A gene promoter:
         HOXA9B   HOXA9   AML1a   STAT5A   POU6F1 (c2)   Evi-1   Meis-1b   PPAR-gamma1   PPAR-gamma2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MRE11A promoter sequence
   Search SABiosciences Chromatin IP Primers for MRE11A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRE11A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21   Ensembl cytogenetic band:  11q21   HGNC cytogenetic band: 11q21

MRE11A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRE11A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M094150:  view genomic region     (about GC identifiers)

Start:
 94,150,466 bp from pter      End:
 94,227,074 bp from pter
Size:
 76,609 bases      Orientation:
 minus strand

Proteins
for MRE11A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MRE11_HUMAN, P49959 (See protein sequence)
Recommended Name: Double-strand break repair protein MRE11A  
Size: 708 amino acids; 80593 Da
Cofactor: Manganese (By similarity)
Subunit: Component of the MRN complex composed of two heterodimers RAD50/MRE11A associated with a single NBN. Component
of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11A and NBN (By similarity).
Interacts with DCLRE1C/Artemis and DCLRE1B/Apollo
Subcellular location: Nucleus (By similarity). Note=Localizes to discrete nuclear foci after treatment with genotoxic
agents (By similarity)
Miscellaneous: In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral
oncoproteins, thereby preventing concatenation of viral genomes in infected cells
1 PDB 3D structure from and Proteopedia for MRE11A:
3T1I (3D)    
Secondary accessions: O43475
Alternative splicing: 2 isoforms:  P49959-1   P49959-2   

Explore the universe of human proteins at neXtProt for MRE11A: NX_P49959

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49959

    • MRE11A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_005581.2  NP_005582.1  

    ENSEMBL proteins: 
     ENSP00000325863   ENSP00000385614   ENSP00000326094   ENSP00000376933   ENSP00000440986  
     ENSP00000439511   ENSP00000442809  
    Reactome Protein details: P49959
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MRE11A Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MRE11A
    OriGene Protein Over-expression Lysate: MRE11A
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    Novus Biologicals MRE11A Proteins
    Novus Biologicals MRE11A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MRE11A

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781colocalizes with chromosome, telomeric region IDA15149599
    GO:0000790nuclear chromatin ----
    GO:0000794condensed nuclear chromosome ----
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--


    MRE11A for ontologies           About GeneDecksing



    MRE11A Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MRE11A
    R&D Systems Antibodies for MRE11A (Mre11)
    Cell Signaling Technology (CST) Antibodies for MRE11A 
    OriGene Antibodies (see all 3): MRE11A
    OriGene Custom Antibody Services for MRE11A 
    GenScript Custom Superior Antibodies Services for MRE11A
    Novus Biologicals MRE11A Antibodies
    Abcam antibodies for MRE11A 
    Uscn Antibodies for MRE11A
    ThermoFisher Antibody for MRE11A

    Assay Products for MRE11A: 
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    GenScript Custom Assay Services for MRE11A
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MRE11A

    Protein Domains /
    Families
    for MRE11A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MRE11A for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR007281 Mre11_DNA-bd
     IPR003701 DNA_repair_Mre11
     IPR004843 Metallo_PEstase_dom

    Graphical View of Domain Structure for InterPro Entry P49959

    ProtoNet protein and cluster: P49959

    1 Blocks protein family: IPB007281 Mre11 DNA-binding presumed domain

    UniProtKB/Swiss-Prot: MRE11_HUMAN, P49959
    Similarity: Belongs to the MRE11/RAD32 family


    Function
    for MRE11A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MRE11_HUMAN, P49959
    Function: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA
    recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease
    activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to
    bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence
    homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the
    nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required
    for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation

         Genatlas biochemistry entry for MRE11A:
    meiotic recombination 11 (yeast RAD52 epistasis group),also involved in DNA double strand break repair

    miRNA
    Products:            		miRTarBase miRNAs that target MRE11A:
    hsa-mir-373 (MIRT003919), hsa-mir-210 (MIRT003916)

    OriGene 3'-UTR Clone (see all 2): MRE11A
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRE11A
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate MRE11A (see all 23):
    hsa-miR-217 hsa-miR-3685 hsa-miR-3607-3p hsa-miR-16-2* hsa-miR-539 hsa-miR-29a hsa-miR-29c hsa-miR-4263
    SwitchGear 3'UTR luciferase reporter plasmid: MRE11A 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRE11A (see all 7)
    OriGene shRNA RFP: MRE11A
    OriGene siRNA: MRE11A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRE11A

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MRE11A

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRE11A (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRE11A (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MRE11A (NM_005591)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRE11A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRE11A 

    Cell Line
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    Search LifeMap BioReagents cell lines for MRE11A

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRE11A

    Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000014single-stranded DNA specific endodeoxyribonuclease activity TAS9705271
    GO:0003677contributes to DNA binding IDA15790808
    GO:0003690double-stranded DNA binding TAS10802669
    GO:0004003contributes to ATP-dependent DNA helicase activity IMP15790808
    GO:0004518nuclease activity TAS15790808


    MRE11A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MRE11A:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Mre11atm2.2Dof for MRE11A
         12 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Mre11a):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  nervous system  other 
     reproductive system  tumorigenesis 

    MRE11A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MRE11A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Non-homologous end-joining
    		Non-homologous end-joining1.00
    		DNA damage_NHEJ mechanisms of DSBs repair0.36
    		Non-homologous end joining0.43
    		DNA damage NHEJ mechanisms of DSBs repair0.36
    2Recruitment of repair and signaling proteins to double-strand breaks
    		Recruitment of repair and signaling proteins to double-strand breaks1.00
    		MRN complex relocalizes to nuclear foci0.50
    		Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks0.50
    		Removal of SPO11 and Resection of 5' Ends of DNA0.30
    3Homologous Recombination Repair
    		Homologous Recombination Repair1.00
    		Double-Strand Break Repair0.71
    		Homologous recombination repair of replication-independent double-strand breaks1.00
    4Integrated Pancreatic Cancer Pathway
    		Integrated Pancreatic Cancer Pathway1.00
    		Integrated Pancreatic Cancer Pathway0.99
    5Homologous recombination
    		Homologous recombination1.00
    		Homologous recombination0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for MRE11A
        DNA damage Role of Brca1 and Brca2 in DNA repair
    DNA damage NHEJ mechanisms of DSBs repair

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MRE11A (see all 6)
        ATM Pathway
    Fanconi's Anaemia Pathway
    BRCA1 Pathway
    DNA Repair Mechanisms
    Chks in Checkpoint Regulation

    2 Cell Signaling Technology (CST) Pathways for MRE11A
        Cell Cycle / Checkpoint Control
    DNA Damage

    2 GeneGo (Thomson Reuters) Pathways for MRE11A
        DNA damage Role of Brca1 and Brca2 in DNA repair
    DNA damage NHEJ mechanisms of DSBs repair

    5/9 BioSystems Pathways for MRE11A (see all 9) 
        Homologous recombination
    DNA damage response
    Integrated Breast Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    Non-homologous end joining

    5/10        Reactome Pathways for MRE11A (see all 10)
        DNA Repair
    Homologous recombination repair of replication-independent double-strand breaks
    Recruitment of repair and signaling proteins to double-strand breaks
    Meiotic Recombination
    Removal of SPO11 and Resection of 5' Ends of DNA


    2         Kegg Pathways  (Kegg details for MRE11A):
        Homologous recombination
    Non-homologous end-joining


    MRE11A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MRE11A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/896 Interacting proteins for MRE11A (P499591, 2, 3 ENSP000003258634) via UniProtKB, MINT, STRING, and/or I2D (see all 896)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAD50Q928782, 3, ENSP000002653354MINT-6805435 MINT-6805527 MINT-6805327 MINT-7906622 MINT-6805250 MINT-7231003 MINT-6805281 MINT-7906581 MINT-7947479 MINT-6805549 MINT-6805304 MINT-7945693 MINT-6805376 MINT-7906600 MINT-8076071 MINT-8076236 I2D: score=6 STRING: ENSP00000265335
    NBNO609341, 2, 3, ENSP000002654334EBI-396513,EBI-494844 MINT-6805435 MINT-6805527 MINT-6805327 MINT-7906622 MINT-6805250 MINT-6805281 MINT-7906581 MINT-7947479 MINT-6805304 MINT-7914712 MINT-7945693 MINT-6805376 MINT-7906600 I2D: score=7 STRING: ENSP00000265433
    MDC1Q146762, 3MINT-6805435 MINT-6805527 MINT-6805327 MINT-6805250 MINT-6805281 MINT-6805549 MINT-6805304 MINT-6805376 I2D: score=3 
    PRKDCP785272, 3, ENSP000003134204MINT-7947479 MINT-7945693 MINT-8076071 MINT-8076236 I2D: score=2 STRING: ENSP00000313420
    H2AFXP161042, 3, ENSP000003643104MINT-6805304 MINT-8303402 I2D: score=4 STRING: ENSP00000364310
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000019regulation of mitotic recombination TAS8530104
    GO:0000075cell cycle checkpoint IEA--
    GO:0000724double-strand break repair via homologous recombination TAS--
    GO:0006259DNA metabolic process ----
    GO:0006281DNA repair TAS--


    MRE11A for ontologies           About GeneDecksing



    Drugs & Compounds
    for MRE11A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MRE11A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRE11A

    1 HMDB Compound for MRE11A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Manganesemanganese 7439-96-5--
    5 Novoseek chemical compound relationships for MRE11A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tin(2+) 77.1 2 12007281 (1), 18077792 (1)
    mononucleotide 59.3 2 16542220 (2)
    camptothecin 38.4 1 18177684 (1)
    mitomycin c 23.3 1 18758156 (1)
    arginine 0 6 15970667 (2), 18285453 (2), 15741314 (1)

    Search CenterWatch for drugs/clinical trials and news about MRE11A / MRE11 

    Transcripts
    for MRE11A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MRE11A gene (2 alternative transcripts): 
    NM_005590.3  NM_005591.3  

    Unigene Cluster for MRE11A:

    MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
    Hs.192649  [show with all ESTs]
    Unigene Representative Sequence: NM_005590
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000323929(uc001peu.2 uc001pev.2 uc009ywj.2) ENST00000407439
    ENST00000323977 ENST00000393241 ENST00000535120 ENST00000536550 ENST00000540013
    ENST00000541157 ENST00000536754 ENST00000538923 ENST00000536144

    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate MRE11A (see all 23):
    hsa-miR-217 hsa-miR-3685 hsa-miR-3607-3p hsa-miR-16-2* hsa-miR-539 hsa-miR-29a hsa-miR-29c hsa-miR-4263
    SwitchGear 3'UTR luciferase reporter plasmid: MRE11A 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRE11A (see all 7)
    OriGene shRNA RFP: MRE11A
    OriGene siRNA: MRE11A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRE11A
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRE11A (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRE11A (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MRE11A (NM_005591)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRE11A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRE11A 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRE11A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRE11A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRE11A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRE11A

    Additional cDNA sequence: 

    AF022778.1 AF073362.1 AK095388.1 AK308318.1 BC005241.1 BC017823.1 BC063458.1 BT006730.1 
    U37359.1 

    7 DOTS entries:

    DT.441210  DT.86852984  DT.100815706  DT.95268844  DT.442694  DT.120701092  DT.91667350 

    24/121 AceView cDNA sequences (see all 121):

    AU116810 AL542543 AA599453 BU622064 AU280269 AA305377 BE327581 BF062725 
    AI859136 NM_005591 BQ232454 AK095388 CF995678 AA256217 BM718776 BM980027 
    BQ423332 AA599357 BX280289 BC063458 BU682949 CN480619 AA932162 NM_005590 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MRE11A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c
    SP1:              -           -                                   -                                                                                             
    SP2:              -                                               -                                                                                             
    SP3:                          -                                   -                                                     -                                       
    SP4:              -           -                                                                                                                                 


    ECgene alternative splicing isoforms for MRE11A

    Expression
    for MRE11A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRE11A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAAGATACAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MRE11A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRE11A

    SOURCE GeneReport for Unigene cluster: Hs.192649
        SABiosciences Expression via Pathway-Focused PCR Arrays including MRE11A: 
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Telomeres & Telomerase in human mouse rat
              DNA Repair in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for MRE11A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MRE11A gene from 10/34 species (see all 34)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mre11a1 , 5 meiotic recombination 11 homolog A (S. cerevisiae)1, 5 84.02(n)1
    88.65(a)1    		   9 (4.33 cM)5
    175351  NM_018736.21  NP_061206.11 
     147846545 
    chicken
    (Gallus gallus)    		 Aves MRE11A1 MRE11 meiotic recombination 11 homolog A (S. cerevisiae) less 73.35(n)
    74.64(a)    		   395555  NM_204778.1  NP_990109.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MRE11A6
    		 --
    		 76(a)
    		 1 ↔ 1
    		 3(195889100-195919029)
    African clawed frog
    (Xenopus laevis)    		 Amphibia mre11-A-prov2 putative nuclease Mre11 74.72(n)    AF134569.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc38f052 Danio rerio cDNA clone MGC64018 IMAGE6793054, complete cds less 74.07(n)    BC053202.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta mre111 , 3 double-strand break repair endonuclease3
    meiotic recombination 111    		 44(a)3
    48.32(n)1
    43.1(a)1    		   32E23
    345651  NM_078823.31  NP_523547.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea mre-111 , 3 Human MRE11 protein like3
    Protein MRE-111    		 39(a)3
    50.34(n)1
    39.35(a)1    		   V(10736734-10739535)3
    1794881  NM_073335.31  NP_505736.21 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes MRE11(YMR224C)4
    MRE111    		 Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for MRX function; widely conserved less4
    Mre11p1    		 53.28(n)1
    44.58(a)1    		   13(720653-718575)4
    8552641, 4  NP_013951.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MRE111 double-strand break repair protein MRE11 48.71(n)
    43.36(a)    		   835514  NM_124806.1  NP_200237.1 
    rice
    (Oryza sativa)    		 Liliopsida Os04g06359001 hypothetical protein 47.68(n)
    39.82(a)    		   4337137  NM_001060547.1  NP_001054012.1 


    ENSEMBL Gene Tree for MRE11A (if available)
    TreeFam Gene Tree for MRE11A (if available) 

    Paralogs
    for MRE11A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRE11A gene

    MRE11A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MRE11A
    PGOHUM00000237832


    Genomic Variants
    for MRE11A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1463 NCBI SNPs in MRE11A are shown (see all 1463)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1048950171,2
    		C,untested143110905(-) ATTCCA/GTCGAA 2 -- int10--------
    rs617492491,2
    		C,F,untested143115928(-) TGATGC/ACCTCG 4 /D /A mis12Minor allele frequency- A:0.01NA EU 5865
    rs1048950161,2
    		C,F,untested143115933(-) CCCTCG/AAAGAC 4 /K /E mis12Minor allele frequency- A:0.00NA 4662
    rs1048950121,2
    		C,untested143145229(-) TATTCA/GTGGCA 2 -- int10--------
    rs1048950041,2
    		C,untested143157091(-) ATATTG/TTTACA 2 -- ut310--------
    rs134477651,2
    		C,--90215840(-) CTTAGC/ATACTC 2 -- ds50011Minor allele frequency- A:0.01NS 172
    rs134477641,2
    		C,F,--90215860(-) TGGTGG/ATGTGT 2 -- ds50011Minor allele frequency- A:0.01NS 172
    rs134477631,2
    		C,--90215922(-) ACCAGC/TCTGGC 2 -- ds50011Minor allele frequency- T:0.01NS 174
    rs134477621,2
    		C,F,--90215985(-) TGCCTT/GTAATC 2 -- ds50012Minor allele frequency- G:0.02NS NA 176
    rs134477611,2
    		H--90216089(-) GTTTTA/TTAAAG 2 -- ut31 ese35Minor allele frequency- T:0.00NS EA 582

    HapMap Linkage Disequilibrium report for MRE11A (94150466 - 94227074 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for MRE11A
         2 CNVs: 85953 101302
         1 Indel: 58541
    Human Gene Mutation Database (HGMD): MRE11A

    Locus Specific Mutation Databases (LSDB): MRE11A

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRE11A
    DNA2.0 Custom Variant and Variant Library Synthesis for MRE11A

    Disorders / Diseases
    for MRE11A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MRE11A for disorders           About GeneDecksing

    OMIM gene information: 600814   
    OMIM disorders: 604391  
    UniProtKB/Swiss-Prot: MRE11_HUMAN, P49959
  • Defects in MRE11A are a cause of ataxia telangiectasia-like disorder (ATLD) [MIM:604391]. ATLD is a disease
    • with the same clinical feature than ataxia-telangiectasia but with a somewhat milder clinical course
  • Note=Defects in MRE11A can be a cause of nephronophthisis-related ciliopathies (NPHP-RC), a group of recessive
    • diseases that affect kidney, retina and brain. A homozygous truncating mutation MRE11A has been found in patients with
    cerebellar vermis hypoplasia, ataxia and dysarthria

    20/43 diseases for MRE11A (see all 43):    About MalaCards
    ataxia-telangiectasia-like disorder    cornelia de lange syndrome    nijmegen breakage syndrome    conjunctivitis
    ataxia telangiectasia    dna topoisomerase i    oculomotor apraxia    non-hodgkin lymphoma
    cerebellar degeneration    xeroderma pigmentosum    fanconi's anemia    werner syndrome
    leukemia/lymphoma    apraxia    leukemia/lymphoma, t-cell    hodgkin's lymphoma
    lynch syndrome    sporadic breast cancer    chronic lymphocytic leukemia    breast-ovarian cancer

    3 diseases from the University of Copenhagen DISEASES database for MRE11A:
    Nijmegen breakage syndrome     Ataxia telangiectasia     Microcephaly

    10/15 Novoseek disease relationships for MRE11A gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia-telangiectasia-like disorder 95.1 8 15269180 (2), 15296753 (1), 20087742 (1), 15234984 (1) (see all 6)
    nijmegen breakage syndrome 93.4 14 10391882 (1), 10888888 (1), 12966088 (1), 15026416 (1) (see all 13)
    ataxia telangiectasia 83.8 18 16905549 (1), 19709933 (1), 11196167 (1), 15574327 (1) (see all 17)
    fanconis anemia 62.4 1 11733219 (1)
    cerebellar degeneration 61.3 2 20087742 (1)
    microsatellite instability 58.4 3 16542220 (1), 15048091 (1), 18606567 (1)
    werner syndrome 47.7 1 11733219 (1)
    colorectal cancer 30.5 4 11850399 (2), 15048091 (1), 18830935 (1)
    chromosomal aberrations 27.4 2 12966088 (1), 8530104 (1)
    cancer 25 11 15048091 (4), 18606567 (2), 16417627 (1), 17143500 (1) (see all 6)

    Human Genome Epidemiology (HuGE) Navigator: MRE11A (26 documents)

    Export disorders for MRE11A gene to outside databases

    Publications
    for MRE11A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRE11A gene, integrated from 9 sources (see all 296):
    (articles sorted by number of sources associating them with MRE11A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of the human MRE11 homologue. (PubMed id 8530104)1, 2, 3, 9 Petrini J.H....Weaver D.T. (1995)
    2. Alterations of the double-strand break repair gene MRE11 in cancer. (PubMed id 11196167)1, 2, 9 Fukuda T.... Miyagawa K. (2001)
    3. The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. (PubMed id 9651580)1, 2, 9 Paull T.T. and Gellert M. (1998)
    4. Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. (PubMed id 22863007)1, 2 Chaki M....Hildebrandt F. (2012)
    5. Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links. (PubMed id 18469862)1, 2 Bae J.B....Legerski R.J. (2008)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage. (PubMed id 15723659)1, 2 Chen L.... Mizutani S. (2005)
    8. Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. (PubMed id 15456891)1, 2 Zhang X....Legerski R.J. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility. (PubMed id 14684699)1, 2 Heikkinen K.... Winqvist R. (2003)

    External Searches for MRE11A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing MRE11A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4361 HGNC: 7230 AceView: MRE11A Ensembl:ENSG00000020922 euGenes: HUgn4361
    ECgene: MRE11A Kegg: 4361 H-InvDB: MRE11A

    Other Databases showing MRE11A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MRE11A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRE11A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MRE11A Genetics and Cytogenetics in Oncology and Haematology
    MRE11basehttp://bioinf.uta.fi/MRE11Abase/
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mre11a/

    Intellectual Property
    for MRE11A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MRE11A gene:
    Search GeneIP for patents involving MRE11A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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