Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MRE11A Gene

protein-coding   GIFtS: 72
GCID: GC11M094150

MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae)

(Previous name: meiotic recombination (S. cerevisiae) 11 homolog A)
(Previous symbol: MRE11)
  See MRE11A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae)1 2     MRE11 Homolog A2 3
MRE111 2 3 5     ATLD2 5
AT-Like Disease1 2     Meiotic Recombination (S. Cerevisiae) 11 Homolog A1
Meiotic Recombination 11 Homolog 12 3     MRE11B2
Meiotic Recombination 11 Homolog A2 3     DNA Recombination And Repair Protein2
HNGS12 3     Double-Strand Break Repair Protein MRE11A2
MRE11 Homolog 12 3     Endo/Exonuclease Mre112

External Ids:    HGNC: 72301   Entrez Gene: 43612   Ensembl: ENSG000000209227   OMIM: 6008145   UniProtKB: P499593   

Export aliases for MRE11A gene to outside databases

Previous GC identifers: GC11M096483 GC11M095658 GC11M094335 GC11M093838 GC11M093790 GC11M090216


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MRE11A Gene:
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA
double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity.
The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA
ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction
with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies
near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene
results in two transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRE11A Gene:
MRE11A (MRE11 meiotic recombination 11 homolog A (S. cerevisiae)) is a protein-coding gene. Diseases associated with MRE11A include early-onset ataxia with oculomotor apraxia and hypoalbuminemia, and nijmegen breakage syndrome. GO annotations related to this gene include manganese ion binding and protein C-terminus binding.

UniProtKB/Swiss-Prot: MRE11_HUMAN, P49959
Function: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA
recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease
activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be
required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long
regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases
and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The
complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN
complex may modulate t-loop formation

Gene Wiki entry for MRE11A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRE11A gene promoter:
         HOXA9B   HOXA9   AML1a   STAT5A   POU6F1 (c2)   Evi-1   Meis-1b   PPAR-gamma1   PPAR-gamma2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRE11A promoter sequence
   Search Chromatin IP Primers for MRE11A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRE11A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21   Ensembl cytogenetic band:  11q21   HGNC cytogenetic band: 11q21

MRE11A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRE11A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M094150:  view genomic region     (about GC identifiers)

Start:
94,150,466 bp from pter      End:
94,227,074 bp from pter
Size:
76,609 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MRE11_HUMAN, P49959 (See protein sequence)
Recommended Name: Double-strand break repair protein MRE11A  
Size: 708 amino acids; 80593 Da
Cofactor: Manganese (By similarity)
Subunit: Component of the MRN complex composed of two heterodimers RAD50/MRE11A associated with a single NBN.
Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11A and NBN (By
similarity). Interacts with DCLRE1C/Artemis and DCLRE1B/Apollo. Interacts with ATF2
Miscellaneous: In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral
oncoproteins, thereby preventing concatenation of viral genomes in infected cells
1 PDB 3D structure from and Proteopedia for MRE11A:
3T1I (3D)    
Secondary accessions: O43475
Alternative splicing: 2 isoforms:  P49959-1   P49959-2   

Explore the universe of human proteins at neXtProt for MRE11A: NX_P49959

Explore proteomics data for MRE11A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys393, Lys416, Lys434, Lys442, Lys475, Lys673
  • Modification sites at PhosphoSitePlus

  • See MRE11A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005581.2  NP_005582.1  

    ENSEMBL proteins: 
     ENSP00000325863   ENSP00000385614   ENSP00000326094   ENSP00000376933   ENSP00000440986  
     ENSP00000439511   ENSP00000442809  
    Reactome Protein details: P49959

    MRE11A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MRE11A
    OriGene Protein Over-expression Lysate for MRE11A
    OriGene MassSpec for MRE11A
    OriGene Custom Protein Services for MRE11A
    GenScript Custom Purified and Recombinant Proteins Services for MRE11A
    Novus Biologicals MRE11A Protein
    Novus Biologicals MRE11A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MRE11A

     
    Search eBioscience for Proteins for MRE11A 

     
    antibodies-online proteins for MRE11A (5 products) 

     
    antibodies-online peptides for MRE11A

    MRE11A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MRE11A
    R&D Systems Antibodies for MRE11A (Mre11)
    Cell Signaling Technology (CST) Antibodies for MRE11A 
    OriGene Antibodies for MRE11A
    OriGene Custom Antibody Services for MRE11A
    Novus Biologicals MRE11A Antibodies
    Abcam antibodies for MRE11A
    Cloud-Clone Corp. Antibodies for MRE11A
    ThermoFisher Antibody for MRE11A
    antibodies-online antibodies for MRE11A (121 products) 

    MRE11A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MRE11A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MRE11A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MRE11A
    Cloud-Clone Corp. CLIAs for MRE11A
    Search eBioscience for ELISAs for MRE11A 
    antibodies-online kits for MRE11A (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR007281 Mre11_DNA-bd
     IPR003701 DNA_repair_Mre11
     IPR004843 PEstase_dom

    Graphical View of Domain Structure for InterPro Entry P49959

    ProtoNet protein and cluster: P49959

    1 Blocks protein domain: IPB007281 Mre11 DNA-binding presumed domain

    UniProtKB/Swiss-Prot: MRE11_HUMAN, P49959
    Similarity: Belongs to the MRE11/RAD32 family


    Find genes that share domains with MRE11A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRE11_HUMAN, P49959
    Function: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA
    recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease
    activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be
    required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long
    regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases
    and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The
    complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN
    complex may modulate t-loop formation

         Genatlas biochemistry entry for MRE11A:
    meiotic recombination 11 (yeast RAD52 epistasis group),also involved in DNA double strand break repair

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000014single-stranded DNA endodeoxyribonuclease activity TAS9705271
    GO:0003677contributes to DNA binding IDA15790808
    GO:0003690double-stranded DNA binding TAS10802669
    GO:0004003contributes to ATP-dependent DNA helicase activity IMP15790808
    GO:0004518nuclease activity TAS15790808
         
    Find genes that share ontologies with MRE11A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MRE11A:
     Upregulation of Wnt/beta-caten 

         12 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Mre11a):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  nervous system  other 
     reproductive system  tumorigenesis 

    Find genes that share phenotypes with MRE11A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mre11atm2.2Dof for MRE11A

       genOway: Develop your customized and physiologically relevant rodent model for MRE11A

    miRNA
    Products:
        
    miRTarBase miRNAs that target MRE11A:
    hsa-mir-1 (MIRT023658), hsa-mir-34a-5p (MIRT025337), hsa-mir-373-3p (MIRT003919), hsa-mir-210-3p (MIRT003916), hsa-mir-30a-5p (MIRT028405), hsa-mir-375 (MIRT019709)

    Block miRNA regulation of human, mouse, rat MRE11A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MRE11A (see all 23):
    hsa-miR-217 hsa-miR-3685 hsa-miR-3607-3p hsa-miR-16-2* hsa-miR-539 hsa-miR-29a hsa-miR-29c hsa-miR-4263
    SwitchGear 3'UTR luciferase reporter plasmidMRE11A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MRE11A
    Predesigned siRNA for gene silencing in human, mouse, rat MRE11A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MRE11A

    Clone
    Products:
         
    OriGene clones in human, mouse for MRE11A (see all 13)
    OriGene ORF clones in mouse, rat for MRE11A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MRE11A (NM_005591)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRE11A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRE11A
    Addgene plasmids for MRE11A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MRE11A
    Browse ESI BIO Cell Lines and PureStem Progenitors for MRE11A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRE11A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MRE11_HUMAN, P49959: Nucleus (By similarity). Note=Localizes to discrete nuclear foci after treatment with
    genotoxic agents (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytoskeleton2
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781colocalizes with chromosome, telomeric region IDA15149599
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with MRE11A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MRE11A About   (see all 22)  
    See pathways by source

    SuperPathContained pathways About
    1Non-homologous end-joining
    Non-homologous end-joining0.37
    Non-homologous end joining0.00
    DNA damage NHEJ mechanisms of DSBs repair0.37
    2Homologous recombination
    Homologous recombination0.40
    Homologous recombination0.40
    3Homologous Recombination Repair
    Homologous Recombination Repair0.70
    Recruitment of repair and signaling proteins to double-strand breaks0.00
    Double-Strand Break Repair0.70
    Homologous recombination repair of replication-independent double-strand breaks0.00
    4Cytosolic sensors of pathogen-associated DNA
    Cytosolic sensors of pathogen-associated DNA0.38
    IRF3-mediated induction of type I IFN0.00
    STING mediated induction of host immune responses0.00
    5Cellular Senescence
    Cellular Senescence0.81
    Cellular responses to stress0.81


    Find genes that share SuperPaths with MRE11A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MRE11A (see all 6)
        ATM Pathway
    Fanconi's Anaemia Pathway
    BRCA1 Pathway
    DNA Repair Mechanisms
    Chks in Checkpoint Regulation

    2 Cell Signaling Technology (CST) Pathways for MRE11A
        Cell Cycle / Checkpoint Control
    DNA Damage

    2 GeneGo (Thomson Reuters) Pathways for MRE11A
        DNA damage Role of Brca1 and Brca2 in DNA repair
    DNA damage NHEJ mechanisms of DSBs repair

    Selected BioSystems Pathways for MRE11A (see all 10)
        DNA damage response
    Homologous recombination
    Integrated Breast Cancer Pathway
    miRNA Regulation of DNA Damage Response
    Non-homologous end joining

    5 Reactome Pathways for MRE11A
        Cytosolic sensors of pathogen-associated DNA
    Meiotic recombination
    Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
    IRF3-mediated induction of type I IFN
    DNA Damage/Telomere Stress Induced Senescence


    2 Kegg Pathways  (Kegg details for MRE11A):
        Homologous recombination
    Non-homologous end-joining

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MRE11A: 
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Telomeres & Telomerase in human mouse rat
              DNA Repair in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MRE11A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MRE11A (P499591, 2, 3 ENSP000003258634) via UniProtKB, MINT, STRING, and/or I2D (see all 1077)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206481Q146762, 3, ENSP000003730604MINT-6805435 MINT-6805527 MINT-6805327 MINT-6805250 MINT-6805281 MINT-6805549 MINT-6805304 MINT-6805376 I2D: score=3 STRING: ENSP00000373060
    ENSG00000237095Q146762, 3, ENSP000004091674MINT-6805435 MINT-6805527 MINT-6805327 MINT-6805250 MINT-6805281 MINT-6805549 MINT-6805304 MINT-6805376 I2D: score=3 STRING: ENSP00000409167
    ENSG00000224587Q146762, 3MINT-6805435 MINT-6805527 MINT-6805327 MINT-6805250 MINT-6805281 MINT-6805549 MINT-6805304 MINT-6805376 I2D: score=3 
    ENSG00000225589Q146762, 3MINT-6805435 MINT-6805527 MINT-6805327 MINT-6805250 MINT-6805281 MINT-6805549 MINT-6805304 MINT-6805376 I2D: score=3 
    ENSG00000228575Q146762, 3MINT-6805435 MINT-6805527 MINT-6805327 MINT-6805250 MINT-6805281 MINT-6805549 MINT-6805304 MINT-6805376 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000019regulation of mitotic recombination TAS8530104
    GO:0000075cell cycle checkpoint ----
    GO:0000724double-strand break repair via homologous recombination TAS--
    GO:0000737DNA catabolic process, endonucleolytic TAS9651580
    GO:0006259DNA metabolic process ----

    Find genes that share ontologies with MRE11A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRE11A (MRE11)

    1 HMDB Compound for MRE11A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Manganesemanganese 7439-96-5--

    5 Novoseek inferred chemical compound relationships for MRE11A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tin(2+) 77.1 2 12007281 (1), 18077792 (1)
    mononucleotide 59.3 2 16542220 (2)
    camptothecin 38.4 1 18177684 (1)
    mitomycin c 23.3 1 18758156 (1)
    arginine 0 6 15970667 (2), 18285453 (2), 15741314 (1)



    Find genes that share compounds with MRE11A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MRE11A gene (2 alternative transcripts): 
    NM_005590.3  NM_005591.3  

    Unigene Cluster for MRE11A:

    MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
    Hs.192649  [show with all ESTs]
    Unigene Representative Sequence: NM_005590
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000323929(uc001peu.2 uc001pev.2 uc009ywj.2) ENST00000407439
    ENST00000323977 ENST00000393241 ENST00000535120 ENST00000540013 ENST00000541157
    ENST00000536754 ENST00000538923 ENST00000536144
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MRE11A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MRE11A (see all 23):
    hsa-miR-217 hsa-miR-3685 hsa-miR-3607-3p hsa-miR-16-2* hsa-miR-539 hsa-miR-29a hsa-miR-29c hsa-miR-4263
    SwitchGear 3'UTR luciferase reporter plasmidMRE11A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MRE11A
    Predesigned siRNA for gene silencing in human, mouse, rat MRE11A
    Clone
    Products:
         
    OriGene clones in human, mouse for MRE11A (see all 13)
    OriGene ORF clones in mouse, rat for MRE11A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MRE11A (NM_005591)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRE11A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRE11A
    Addgene plasmids for MRE11A 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MRE11A
    OriGene qSTAR qPCR primer pairs in human, mouse for MRE11A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRE11A
      QuantiTect SYBR Green Assays in human, mouse, rat MRE11A
      QuantiFast Probe-based Assays in human, mouse, rat MRE11A

    Additional mRNA sequence: 

    AF022778.1 AF073362.1 AK095388.1 AK308318.1 BC005241.1 BC017823.1 BC063458.1 BT006730.1 
    U37359.1 

    7 DOTS entries:

    DT.441210  DT.86852984  DT.100815706  DT.95268844  DT.442694  DT.120701092  DT.91667350 

    Selected AceView cDNA sequences (see all 121):

    BQ423332 CN480619 AA932162 BM718776 BC063458 AA421832 BM980027 CF995678 
    NM_005591 BX280289 AA599357 AI859136 AL542543 BU682949 BE327581 AF073362 
    BC017823 CR600174 AU280269 AU116810 AA599453 AA256217 BC005241 NM_005590 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MRE11A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c
    SP1:              -           -                                   -                                                                                             
    SP2:              -                                               -                                                                                             
    SP3:                          -                                   -                                                     -                                       
    SP4:              -           -                                                                                                                                 


    ECgene alternative splicing isoforms for MRE11A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MRE11A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGATACAG
    MRE11A Expression
    About this image


    MRE11A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    MRE11A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRE11A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.192649
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MRE11A: 
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Telomeres & Telomerase in human mouse rat
              DNA Repair in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MRE11A
    OriGene qSTAR qPCR primer pairs in human, mouse for MRE11A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRE11A
    QuantiTect SYBR Green Assays in human, mouse, rat MRE11A
    QuantiFast Probe-based Assays in human, mouse, rat MRE11A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRE11A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MRE11A gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mre11a1 , 5 meiotic recombination 11 homolog A (S. cerevisiae)1, 5 84.02(n)1
    88.65(a)1
      9 (4.33 cM)5
    175351  NM_018736.21  NP_061206.11 
     147846545 
    chicken
    (Gallus gallus)
    Aves MRE11A1 MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 72.83(n)
    73.35(a)
      395555  NM_204778.1  NP_990109.1 
    lizard
    (Anolis carolinensis)
    Reptilia MRE11A6
    MRE11 meiotic recombination 11 homolog A (S. cerev...
    76(a)
    1 ↔ 1
    3(195889100-195922709)
    African clawed frog
    (Xenopus laevis)
    Amphibia mre11-A-prov2 putative nuclease Mre11 74.72(n)    AF134569.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc38f052 Danio rerio cDNA clone MGC64018 IMAGE6793054, complete more 74.07(n)    BC053202.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mre111 , 3 double-strand break repair endonuclease3
    meiotic recombination 111
    44(a)3
    50.47(n)1
    46.96(a)1
      32E23
    345651  NM_078823.41  NP_523547.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mre-111 , 3 Human MRE11 protein like3
    mre-111
    39(a)3
    52.52(n)1
    42.45(a)1
      V(10736734-10739535)3
    1794881  NM_073335.41  NP_505736.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MRE11(YMR224C)4
    MRE111
    Subunit of a complex with Rad50p and Xrs2p (MRX complex) more4
    MRE111
    52.41(n)1
    44.98(a)1
      13(720653-718575)4
    8552641, 4  NP_013951.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MRE111 MRE11 49.36(n)
    43.03(a)
      835514  NM_124806.1  NP_200237.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g06359001 Os04g0635900 52.19(n)
    46.82(a)
      4337137  NM_001060547.1  NP_001054012.1 


    ENSEMBL Gene Tree for MRE11A (if available)
    TreeFam Gene Tree for MRE11A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MRE11A gene

    Find genes that share paralogs with MRE11A           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MRE11A
    PGOHUM00000237832


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MRE11A (see all 1737)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2000851461,2,,4
    Cancer4 --94051202(+) TTCCTC/TGGCCT 4 Q R mis10--------
    VAR_0085134
    Ataxia-telangiectasia-like disorder (ATLD)4--see VAR_0085132 N S mis40--------
    VAR_0364174
    A breast cancer sample4--see VAR_0364172 H Y mis40--------
    VAR_0116254
    Cancer4--see VAR_0116252 S C mis40--------
    VAR_0255284
    Ovarian cancer4--see VAR_0255282 R W mis40--------
    VAR_0364164
    A breast cancer sample4--see VAR_0364162 F C mis40--------
    VAR_0116274
    Cancer4--see VAR_0116272 R H mis40--------
    rs1378527591,2
    Cpathogenic194041122(-) CTTCCA/C/TGAAAT 4 R * stg10--------
    rs1048950041,2
    Cuntested194022109(-) ATATTG/TTTACA 2 -- ut310--------
    rs1048950121,2
    C,Funtested194033996(-) TATTCA/GTGGCA 2 -- int10--------

    HapMap Linkage Disequilibrium report for MRE11A (94150466 - 94227074 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MRE11A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2575562CNV Deletion19546169
    esv2671948CNV Deletion23128226
    nsv443CNV Insertion18451855
    nsv820080CNV Loss19587683
    nsv523083CNV Gain19592680
    nsv832233CNV Gain17160897

    Human Gene Mutation Database (HGMD): MRE11A
    Locus Specific Mutation Databases (LSDB): MRE11A

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRE11A
    DNA2.0 Custom Variant and Variant Library Synthesis for MRE11A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600814   
    OMIM disorders: 604391  
    UniProtKB/Swiss-Prot: MRE11_HUMAN, P49959
  • Ataxia-telangiectasia-like disorder (ATLD) [MIM:604391]: A rare disorder characterized by progressive
    cerebellar ataxia, dysarthria, abnormal eye movements, and absence of telangiectasia. ATLD patients show normal
    levels of total IgG, IgA and IgM, although there may be reduced levels of specific functional antibodies. At the
    cellular level, ATLD exhibits hypersensitivity to ionizing radiation and radioresistant DNA synthesis. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Note=Defects in MRE11A can be a cause of nephronophthisis-related ciliopathies (NPHP-RC), a group of
    recessive diseases that affect kidney, retina and brain. A homozygous truncating mutation MRE11A has been found
    in patients with cerebellar vermis hypoplasia, ataxia and dysarthria

  • 7 diseases for MRE11A:    
    About MalaCards
    early-onset ataxia with oculomotor apraxia and hypoalbuminemia    nijmegen breakage syndrome    apraxia    cerebellar degeneration
    ataxia telangiectasia    breast-ovarian cancer, familial, 2    colorectal cancer

    5 diseases from the University of Copenhagen DISEASES database for MRE11A:
    Nijmegen breakage syndrome     Ataxia telangiectasia     Fanconi's anemia     Microcephaly
    Apraxia

    Find genes that share disorders with MRE11A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MRE11A gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia-telangiectasia-like disorder 95.1 8 15269180 (2), 15296753 (1), 20087742 (1), 15234984 (1) (see all 6)
    nijmegen breakage syndrome 93.4 14 10391882 (1), 10888888 (1), 12966088 (1), 15026416 (1) (see all 13)
    ataxia telangiectasia 83.8 18 16905549 (1), 19709933 (1), 11196167 (1), 15574327 (1) (see all 17)
    fanconis anemia 62.4 1 11733219 (1)
    cerebellar degeneration 61.3 2 20087742 (1)
    microsatellite instability 58.4 3 16542220 (1), 15048091 (1), 18606567 (1)
    werner syndrome 47.7 1 11733219 (1)
    colorectal cancer 30.5 4 11850399 (2), 15048091 (1), 18830935 (1)
    chromosomal aberrations 27.4 2 12966088 (1), 8530104 (1)
    cancer 25 11 15048091 (4), 18606567 (2), 16417627 (1), 17143500 (1) (see all 6)

    Genetic Association Database (GAD): MRE11A
    Human Genome Epidemiology (HuGE) Navigator: MRE11A (26 documents)

    Export disorders for MRE11A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MRE11A gene, integrated from 10 sources (see all 317):
    (articles sorted by number of sources associating them with MRE11A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of the human MRE11 homologue. (PubMed id 8530104)1, 2, 3, 9 Petrini J.H.J....Weaver D.T. (Genomics 1995)
    2. Alterations of the double-strand break repair gene MRE11 in cancer. (PubMed id 11196167)1, 2, 9 Fukuda T.... Miyagawa K. (Cancer Res. 2001)
    3. The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. (PubMed id 9651580)1, 2, 9 Paull T.T. and Gellert M. (Mol. Cell 1998)
    4. Assessment of carriers' frequency of a novel MRE11 mutation responsible for the rare ataxia telangiectasia-like disorder. (PubMed id 18652530)1, 4, 9 Alsbeih G....Al-Harbi N. (Genet. Test. 2008)
    5. Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex. (PubMed id 17932350)1, 4, 9 Hsu H.M....Yu J.C. (amp 2007)
    6. Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patients. (PubMed id 19638463)1, 4, 9 Pugh T.J....Moore R.A. (Clin. Cancer Res. 2009)
    7. Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma. (PubMed id 19917125)1, 4, 9 Schuetz J.M....Brooks-Wilson A.R. (BMC Med. Genet. 2009)
    8. Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. (PubMed id 22863007)1, 2 Chaki M....Hildebrandt F. (Cell 2012)
    9. Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. (PubMed id 20496165)1, 4 Monsees G.M....Han J. (Breast Cancer Res. Treat. 2011)
    10. Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies. (PubMed id 20813000)1, 4 Shen M....Zheng T. (Br. J. Haematol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4361 HGNC: 7230 AceView: MRE11A Ensembl:ENSG00000020922 euGenes: HUgn4361
    ECgene: MRE11A Kegg: 4361 H-InvDB: MRE11A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MRE11A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MRE11A Genetics and Cytogenetics in Oncology and Haematology
    MRE11basehttp://bioinf.uta.fi/MRE11Abase/
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mre11a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MRE11A gene:
    Search GeneIP for patents involving MRE11A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of MRE11A
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for MRE11A (Mre11)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MRE11A   OriGene RNAi products in human, mouse, rat for MRE11A  
     OriGene qPCR primer pairs and template standards for MRE11A   OriGene Protein Over-expression Lysate for MRE11A  
     OriGene MassSpec for MRE11A   OriGene clones in human, mouse for MRE11A  
     OriGene qSTAR qPCR primer pairs in human, mouse for MRE11A   OriGene Purified Protein for MRE11A  
     OriGene ORF clones in mouse, rat for MRE11A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MRE11A   OriGene Custom Protein Services for MRE11A  

     
     
     Block miRNA regulation of human, mouse, rat MRE11A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MRE11A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRE11A Predesigned siRNA for gene silencing in human, mouse, rat MRE11A
     QuantiFast Probe-based Assays in human, mouse, rat MRE11A QuantiTect SYBR Green Assays in human, mouse, rat MRE11A
     PCR Arrays including human, mouse, rat MRE11A Search Chromatin IP Primers for MRE11A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRE11A  GeneGlobe Interaction Network for MRE11A
     Regulatory tfbs in MRE11A promoter
     GenScript Custom Purified and Recombinant Proteins Services for MRE11A GenScript cDNA clones with any tag delivered in your preferred vector for MRE11A
     GenScript Custom Assay Services for MRE11A GenScript Custom overexpressing Cell Line Services for MRE11A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for MRE11A 

     Search Tocris compounds for MRE11A (MRE11)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MRE11A antibodies
     MRE11A proteins
     MRE11A lysates
     Antibodies for MRE11A
     See all of Abcam's Antibodies, Kits and Proteins for MRE11A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MRE11A
     Antibodies for MRE11A
     ELISAs for MRE11A
     CLIAs for MRE11A



     Browse ESI BIO Cell Lines and PureStem Progenitors for MRE11A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRE11A
     SwitchGear 3'UTR luciferase reporter plasmids for MRE11A
     SwitchGear Promoter luciferase reporter plasmids for MRE11A
     ThermoFisher Antibody for MRE11A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRE11A
     Browse compounds at ApexBio
     Addgene plasmids for MRE11A
      Search eBioscience for proteins for MRE11A
      Search eBioscience for elisas for MRE11A
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for MRE11A
     antibodies-online antibodies for MRE11A (121 products)
     antibodies-online kits for MRE11A (9 products)
     antibodies-online peptides for MRE11A
     antibodies-online proteins for MRE11A (5 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MRE11A gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4