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Aliases for MRC2 Gene

Aliases for MRC2 Gene

  • Mannose Receptor, C Type 2 2 3
  • ENDO180 3 4 6
  • UPARAP 3 4 6
  • Urokinase-Type Plasminogen Activator Receptor-Associated Protein 3 4
  • C-Type Lectin Domain Family 13 Member E 3 4
  • Macrophage Mannose Receptor 2 3 4
  • UPAR-Associated Protein 3 4
  • Endocytic Receptor 180 3 4
  • CLEC13E 3 4
  • CD280 3 6
  • Endocytic Receptor (Macrophage Mannose Receptor Family) 3
  • Urokinase Receptor-Associated Protein 4
  • C-Type Mannose Receptor 2 3
  • CD280 Antigen 4
  • KIAA0709 4

External Ids for MRC2 Gene

Summaries for MRC2 Gene

Entrez Gene Summary for MRC2 Gene

  • This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]

GeneCards Summary for MRC2 Gene

MRC2 (Mannose Receptor, C Type 2) is a Protein Coding gene. Diseases associated with MRC2 include breast cancer. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is PLA2R1.

UniProtKB/Swiss-Prot for MRC2 Gene

  • May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRC2 Gene

Genomics for MRC2 Gene

Genomic Location for MRC2 Gene

Start:
62,627,401 bp from pter
End:
62,693,601 bp from pter
Size:
66,201 bases
Orientation:
Plus strand

Genomic View for MRC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRC2 Gene

Regulatory Elements for MRC2 Gene

Proteins for MRC2 Gene

  • Protein details for MRC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBG0-MRC2_HUMAN
    Recommended name:
    C-type mannose receptor 2
    Protein Accession:
    Q9UBG0
    Secondary Accessions:
    • A6H8K4
    • D3DU08
    • Q7LGE7
    • Q9Y5P9

    Protein attributes for MRC2 Gene

    Size:
    1479 amino acids
    Molecular mass:
    166674 Da
    Quaternary structure:
    • Interacts with C-terminal region of type I collagen/COL1A1 (By similarity). Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V.
    SequenceCaution:
    • Sequence=BAA31684.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for MRC2 Gene

Proteomics data for MRC2 Gene at MOPED

Post-translational modifications for MRC2 Gene

  • N-glycosylated.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn69, Asn140, Asn364, Thr370, Asn497, Asn588, Asn954, Asn1029, Asn1350, and Asn1386

Other Protein References for MRC2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MRC2 Gene

Domains for MRC2 Gene

Gene Families for MRC2 Gene

HGNC:
  • CD :CD molecules
  • CLEC :C-type lectin domain containing

UniProtKB/Swiss-Prot:

MRC2_HUMAN
Domain:
  • C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner:
    • Q9UBG0
  • Fibronectin type-II domain mediates collagen-binding:
    • Q9UBG0
  • Ricin B-type lectin domain contacts with the second C-type lectin domain.:
    • Q9UBG0
  • Contains 8 C-type lectin domains.:
    • Q9UBG0
  • Contains 1 fibronectin type-II domain.:
    • Q9UBG0
  • Contains 1 ricin B-type lectin domain.:
    • Q9UBG0
genes like me logo Genes that share domains with MRC2: view

Function for MRC2 Gene

Molecular function for MRC2 Gene

UniProtKB/Swiss-Prot Function: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).

Gene Ontology (GO) - Molecular Function for MRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 7904248
GO:0005518 collagen binding IDA 10636902
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with MRC2: view
genes like me logo Genes that share phenotypes with MRC2: view

Animal Models for MRC2 Gene

MGI Knock Outs for MRC2:

miRNA for MRC2 Gene

miRTarBase miRNAs that target MRC2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MRC2 Gene

Localization for MRC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRC2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRC2 Gene COMPARTMENTS Subcellular localization image for MRC2 gene
Compartment Confidence
plasma membrane 3
extracellular 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for MRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IDA 16210410
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MRC2: view

Pathways for MRC2 Gene

genes like me logo Genes that share pathways with MRC2: view

Interacting Proteins for MRC2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000307513%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000333982%0d%0a
Selected Interacting proteins: ENSP00000307513 Q9UBG0-MRC2_HUMAN for MRC2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006897 endocytosis IEA --
GO:0030574 collagen catabolic process IDA 12972549
genes like me logo Genes that share ontologies with MRC2: view

Compounds for MRC2 Gene

(1) HMDB Compounds for MRC2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(2) Novoseek inferred chemical compound relationships for MRC2 Gene

Compound -log(P) Hits PubMed IDs
mannose 72.5 14
n-acetylglucosamine 38.3 1
genes like me logo Genes that share compounds with MRC2: view

Transcripts for MRC2 Gene

Unigene Clusters for MRC2 Gene

Mannose receptor, C type 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ·
SP1: - - -
SP2:
SP3: -
SP4: -
SP5: -
SP6: - - - - - - - - - - - - - - - - - - - - -
SP7:
SP8:

ExUns: 19c ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6: - - - - - - - - -
SP7: - -
SP8: -

Relevant External Links for MRC2 Gene

GeneLoc Exon Structure for
MRC2
ECgene alternative splicing isoforms for
MRC2

Expression for MRC2 Gene

mRNA expression in normal human tissues for MRC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRC2 Gene

SOURCE GeneReport for Unigene cluster for MRC2 Gene Hs.7835

mRNA Expression by UniProt/SwissProt for MRC2 Gene

Q9UBG0-MRC2_HUMAN
Tissue specificity: Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.
genes like me logo Genes that share expressions with MRC2: view

Orthologs for MRC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRC2 36
  • 99.39 (n)
  • 99.73 (a)
MRC2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRC2 36
  • 91.2 (n)
  • 93.91 (a)
MRC2 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRC2 36
  • 91.2 (n)
  • 94.82 (a)
MRC2 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrc2 36
  • 87.86 (n)
  • 91 (a)
Mrc2 16
Mrc2 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRC2 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRC2 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrc2 36
  • 87.54 (n)
  • 90.18 (a)
chicken
(Gallus gallus)
Aves MRC2 36
  • 76.35 (n)
  • 74.65 (a)
MRC2 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRC2 37
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1977 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mrc2 36
  • 63.92 (n)
  • 61.88 (a)
zebrafish
(Danio rerio)
Actinopterygii mrc2 36
  • 57.69 (n)
  • 51.56 (a)
MRC2 37
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea clec-148 37
  • 20 (a)
ManyToMany
clec-48 37
  • 27 (a)
ManyToMany
clec-49 37
  • 27 (a)
ManyToMany
clec-50 37
  • 28 (a)
ManyToMany
clec-51 37
  • 22 (a)
ManyToMany
clec-52 37
  • 22 (a)
ManyToMany
clec-53 37
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToMany
Species with no ortholog for MRC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRC2 Gene

ENSEMBL:
Gene Tree for MRC2 (if available)
TreeFam:
Gene Tree for MRC2 (if available)

Paralogs for MRC2 Gene

Paralogs for MRC2 Gene

Selected SIMAP similar genes for MRC2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MRC2: view

Variants for MRC2 Gene

Sequence variations from dbSNP and Humsavar for MRC2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs10328 -- 62,693,284(+) GGGGA(A/G)GGGTT utr-variant-3-prime
rs729647 -- 62,671,565(-) CAGGC(A/G)AGGCC intron-variant
rs740698 -- 62,689,790(-) GGCTG(A/G)GGCCC intron-variant
rs2014055 - 62,664,556(-) GAAGA(C/T)GTTGG missense, reference
rs2041284 -- 62,638,143(-) GCTCA(C/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRC2 Gene

Variant ID Type Subtype PubMed ID
nsv509664 CNV Insertion 20534489
nsv908680 CNV Loss 21882294
nsv470595 CNV Loss 18288195
nsv516921 CNV Gain+Loss 19592680
nsv2115 CNV Insertion 18451855

Relevant External Links for MRC2 Gene

HapMap Linkage Disequilibrium report
MRC2
Human Gene Mutation Database (HGMD)
MRC2

Disorders for MRC2 Gene

(1) MalaCards Diseases for MRC2 Gene

Search for MRC2 Gene in MalaCards »

(2) Novoseek inferred disease relationships for MRC2 Gene

Disease -log(P) Hits PubMed IDs
osteoarthritis 11.8 3
tumors 0 3

Relevant External Links for MRC2

Genetic Association Database (GAD)
MRC2
Human Genome Epidemiology (HuGE) Navigator
MRC2
genes like me logo Genes that share disorders with MRC2: view

No data available for UniProtKB/Swiss-Prot for MRC2 Gene

Publications for MRC2 Gene

  1. A urokinase receptor-associated protein with specific collagen binding properties. (PMID: 10636902) Behrendt N. … Danoe K. (J. Biol. Chem. 2000) 3 4 23
  2. Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor. (PMID: 12972549) Wienke D. … Isacke C.M. (Mol. Biol. Cell 2003) 3 4 23
  3. The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family. (PMID: 12068012) Howard M.J. … Isacke C.M. (J. Biol. Chem. 2002) 3 4 23
  4. Characterization of sugar binding by the mannose receptor family member, Endo180. (PMID: 12399458) East L. … Isacke C.M. (J. Biol. Chem. 2002) 3 4 23
  5. Characterization of a novel member of the macrophage mannose receptor type C lectin family. (PMID: 8702911) Wu K. … Lasky L.A. (J. Biol. Chem. 1996) 2 3 4

Products for MRC2 Gene

Sources for MRC2 Gene

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