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Aliases for MRC2 Gene

Aliases for MRC2 Gene

  • Mannose Receptor C Type 2 2 3
  • C-Type Lectin Domain Family 13 Member E 2 3 4
  • Mannose Receptor, C Type 2 2 3 5
  • Endocytic Receptor 180 2 3 4
  • Urokinase-Type Plasminogen Activator Receptor-Associated Protein 3 4
  • Macrophage Mannose Receptor 2 3 4
  • UPAR-Associated Protein 3 4
  • CLEC13E 3 4
  • ENDO180 3 4
  • UPARAP 3 4
  • Endocytic Receptor (Macrophage Mannose Receptor Family) 3
  • Urokinase Receptor-Associated Protein 4
  • CD280 Antigen 4
  • KIAA0709 4
  • CD280 3

External Ids for MRC2 Gene

Previous GeneCards Identifiers for MRC2 Gene

  • GC17P060392
  • GC17P063131
  • GC17P061045
  • GC17P061178
  • GC17P058058
  • GC17P060704
  • GC17P056071

Summaries for MRC2 Gene

Entrez Gene Summary for MRC2 Gene

  • This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]

GeneCards Summary for MRC2 Gene

MRC2 (Mannose Receptor C Type 2) is a Protein Coding gene. Among its related pathways are Immune System and Phagosome. GO annotations related to this gene include carbohydrate binding and collagen binding. An important paralog of this gene is PLA2R1.

UniProtKB/Swiss-Prot for MRC2 Gene

  • May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRC2 Gene

Genomics for MRC2 Gene

Regulatory Elements for MRC2 Gene

Promoters for MRC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRC2 Gene

Chromosome:
17
Start:
62,626,515 bp from pter
End:
62,693,601 bp from pter
Size:
67,087 bases
Orientation:
Plus strand

Genomic View for MRC2 Gene

Genes around MRC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRC2 Gene

Proteins for MRC2 Gene

  • Protein details for MRC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBG0-MRC2_HUMAN
    Recommended name:
    C-type mannose receptor 2
    Protein Accession:
    Q9UBG0
    Secondary Accessions:
    • A6H8K4
    • D3DU08
    • Q7LGE7
    • Q9Y5P9

    Protein attributes for MRC2 Gene

    Size:
    1479 amino acids
    Molecular mass:
    166674 Da
    Quaternary structure:
    • Interacts with C-terminal region of type I collagen/COL1A1 (By similarity). Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V.
    SequenceCaution:
    • Sequence=BAA31684.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRC2 Gene

neXtProt entry for MRC2 Gene

Proteomics data for MRC2 Gene at MOPED

Post-translational modifications for MRC2 Gene

  • N-glycosylated.
  • Glycosylation at Asn 69, Asn 140, Asn 364, Thr 370, Asn 497, Asn 588, Asn 954, Asn 1029, Asn 1350, and Asn 1386
  • Modification sites at PhosphoSitePlus

Other Protein References for MRC2 Gene

Antibody Products

No data available for DME Specific Peptides for MRC2 Gene

Domains & Families for MRC2 Gene

Gene Families for MRC2 Gene

Suggested Antigen Peptide Sequences for MRC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBG0

UniProtKB/Swiss-Prot:

MRC2_HUMAN :
  • C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.
Domain:
  • C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.
  • Fibronectin type-II domain mediates collagen-binding.
  • Ricin B-type lectin domain contacts with the second C-type lectin domain.
  • Contains 8 C-type lectin domains.
  • Contains 1 fibronectin type-II domain.
  • Contains 1 ricin B-type lectin domain.
genes like me logo Genes that share domains with MRC2: view

Function for MRC2 Gene

Molecular function for MRC2 Gene

UniProtKB/Swiss-Prot Function:
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
genes like me logo Genes that share phenotypes with MRC2: view

Animal Models for MRC2 Gene

MGI Knock Outs for MRC2:

Animal Model Products

  • Taconic Biosciences Mouse Models for MRC2

miRNA for MRC2 Gene

miRTarBase miRNAs that target MRC2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRC2 Gene

Localization for MRC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRC2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRC2 Gene COMPARTMENTS Subcellular localization image for MRC2 gene
Compartment Confidence
plasma membrane 3
endosome 2
extracellular 2
lysosome 2
peroxisome 2
vacuole 2

Gene Ontology (GO) - Cellular Components for MRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 16210410
genes like me logo Genes that share ontologies with MRC2: view

Pathways & Interactions for MRC2 Gene

genes like me logo Genes that share pathways with MRC2: view

Interacting Proteins for MRC2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000307513%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000333982%0d%0a
Selected Interacting proteins: ENSP00000307513 Q9UBG0-MRC2_HUMAN for MRC2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MRC2 Gene

None

No data available for SIGNOR curated interactions for MRC2 Gene

Drugs & Compounds for MRC2 Gene

(1) Drugs for MRC2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(2) Additional Compounds for MRC2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MRC2: view

Transcripts for MRC2 Gene

Unigene Clusters for MRC2 Gene

Mannose receptor, C type 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ·
SP1: - - -
SP2:
SP3: -
SP4: -
SP5: -
SP6: - - - - - - - - - - - - - - - - - - - - -
SP7:
SP8:

ExUns: 19c ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6: - - - - - - - - -
SP7: - -
SP8: -

Relevant External Links for MRC2 Gene

GeneLoc Exon Structure for
MRC2
ECgene alternative splicing isoforms for
MRC2

Expression for MRC2 Gene

mRNA expression in normal human tissues for MRC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRC2 Gene

This gene is overexpressed in Cerebral cortex (20.1) and Liver (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MRC2 Gene



SOURCE GeneReport for Unigene cluster for MRC2 Gene Hs.7835

mRNA Expression by UniProt/SwissProt for MRC2 Gene

Q9UBG0-MRC2_HUMAN
Tissue specificity: Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.
genes like me logo Genes that share expression patterns with MRC2: view

Protein tissue co-expression partners for MRC2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MRC2 Gene

Orthologs for MRC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRC2 35
  • 99.39 (n)
  • 99.73 (a)
MRC2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRC2 36
  • 94 (a)
OneToOne
MRC2 35
  • 91.2 (n)
  • 93.91 (a)
dog
(Canis familiaris)
Mammalia MRC2 35
  • 91.2 (n)
  • 94.82 (a)
MRC2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrc2 16
Mrc2 36
  • 91 (a)
OneToOne
Mrc2 35
  • 87.86 (n)
  • 91 (a)
oppossum
(Monodelphis domestica)
Mammalia MRC2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRC2 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrc2 35
  • 87.54 (n)
  • 90.18 (a)
chicken
(Gallus gallus)
Aves MRC2 36
  • 75 (a)
OneToOne
MRC2 35
  • 76.35 (n)
  • 74.65 (a)
lizard
(Anolis carolinensis)
Reptilia MRC2 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1977 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mrc2 35
  • 63.92 (n)
  • 61.88 (a)
zebrafish
(Danio rerio)
Actinopterygii mrc2 35
  • 57.69 (n)
  • 51.56 (a)
MRC2 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea clec-148 36
  • 20 (a)
ManyToMany
clec-48 36
  • 27 (a)
ManyToMany
clec-49 36
  • 27 (a)
ManyToMany
clec-50 36
  • 28 (a)
ManyToMany
clec-51 36
  • 22 (a)
ManyToMany
clec-52 36
  • 22 (a)
ManyToMany
clec-53 36
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for MRC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRC2 Gene

ENSEMBL:
Gene Tree for MRC2 (if available)
TreeFam:
Gene Tree for MRC2 (if available)

Paralogs for MRC2 Gene

Paralogs for MRC2 Gene

(7) SIMAP similar genes for MRC2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MRC2: view

Variants for MRC2 Gene

Sequence variations from dbSNP and Humsavar for MRC2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2014055 - 62,664,556(-) GAAGA(C/T)GTTGG nc-transcript-variant, reference, missense
rs2429387 - 62,689,654(-) CATTG(C/T)GGCTC intron-variant, downstream-variant-500B, reference, missense
rs10328 -- 62,693,284(+) GGGGA(A/G)GGGTT utr-variant-3-prime
rs729647 -- 62,671,565(-) CAGGC(A/G)AGGCC intron-variant
rs740698 -- 62,689,790(-) GGCTG(A/G)GGCCC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MRC2 Gene

Variant ID Type Subtype PubMed ID
nsv509664 CNV Insertion 20534489
nsv908680 CNV Loss 21882294
nsv470595 CNV Loss 18288195
nsv516921 CNV Gain+Loss 19592680
nsv2115 CNV Insertion 18451855

Variation tolerance for MRC2 Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.03; 75.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRC2 Gene

HapMap Linkage Disequilibrium report
MRC2
Human Gene Mutation Database (HGMD)
MRC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRC2 Gene

Disorders for MRC2 Gene

Relevant External Links for MRC2

Genetic Association Database (GAD)
MRC2
Human Genome Epidemiology (HuGE) Navigator
MRC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRC2

No disorders were found for MRC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRC2 Gene

Publications for MRC2 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion. (PMID: 20339555) Huijbers I.J. … Isacke C.M. (PLoS ONE 2010) 3 23
  3. Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180. (PMID: 19861500) Messaritou G. … Yarwood H. (J. Cell. Sci. 2009) 3 23
  4. Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer. (PMID: 17189524) Sulek J. … Bugge T.H. (J. Histochem. Cytochem. 2007) 3 23
  5. Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor. (PMID: 12972549) Wienke D. … Isacke C.M. (Mol. Biol. Cell 2003) 3 23

Products for MRC2 Gene

Sources for MRC2 Gene

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