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MRC2 Gene

protein-coding   GIFtS: 63
GCID: GC17P060704

Mannose Receptor, C Type 2

  See MRC2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mannose Receptor, C Type 21 2     UPAR-Associated Protein2 3
ENDO1802 3 5     CD2802 5
UPARAP2 3 5     C-Type Mannose Receptor 22
Endocytic Receptor 1802 3     Endocytic Receptor (Macrophage Mannose Receptor Family)2
Macrophage Mannose Receptor 22 3     KIAA07093
Urokinase-Type Plasminogen Activator Receptor-Associated Protein2 3     CD280 Antigen3
CLEC13E2 3     Urokinase Receptor-Associated Protein3
C-Type Lectin Domain Family 13 Member E2 3     

External Ids:    HGNC: 168751   Entrez Gene: 99022   Ensembl: ENSG000000110287   OMIM: 6122645   UniProtKB: Q9UBG03   

Export aliases for MRC2 gene to outside databases

Previous GC identifers: GC17P060392 GC17P063131 GC17P061045 GC17P061178 GC17P058058 GC17P056071


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRC2 Gene:
This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain
and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by
mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a
role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic
bone disease. (provided by RefSeq, Feb 2012)

GeneCards Summary for MRC2 Gene:
MRC2 (mannose receptor, C type 2) is a protein-coding gene. Diseases associated with MRC2 include breast cancer. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is LY75.

UniProtKB/Swiss-Prot: MRC2_HUMAN, Q9UBG0
Function: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity.
Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via
clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular
level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular
uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression
as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in
remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRC2 gene promoter:
         Pax-5   NRSF form 1   MyoD   C/EBPalpha   NF-AT   NF-AT4   NF-AT2   NF-AT3   ATF   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRC2 promoter sequence
   Search Chromatin IP Primers for MRC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2   Ensembl cytogenetic band:  17q23.2   HGNC cytogenetic band: 17q23

MRC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRC2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P060704:  view genomic region     (about GC identifiers)

Start:
60,704,762 bp from pter      End:
60,770,958 bp from pter
Size:
66,197 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MRC2_HUMAN, Q9UBG0 (See protein sequence)
Recommended Name: C-type mannose receptor 2 precursor  
Size: 1479 amino acids; 166674 Da
Subunit: Interacts with C-terminal region of type I collagen/COL1A1 (By similarity). Interacts directly with
PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V
Sequence caution: Sequence=BAA31684.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A6H8K4 D3DU08 Q7LGE7 Q9Y5P9

Explore the universe of human proteins at neXtProt for MRC2: NX_Q9UBG0

Explore proteomics data for MRC2 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn69, Asn140, Asn364, Thr370, Asn497, Asn588, Asn954, Asn1029, Asn1350, Asn1386
  • Modification sites at PhosphoSitePlus

  • See MRC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006030.2  
    ENSEMBL proteins: 
     ENSP00000307513   ENSP00000461968   ENSP00000463968   ENSP00000400445  
    Reactome Protein details: Q9UBG0

    MRC2 Human Recombinant Protein Products:

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    Novus Biologicals MRC2 Protein
    Novus Biologicals MRC2 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MRC2

     
    Search eBioscience for Proteins for MRC2 

     
    antibodies-online proteins for MRC2 (2 products) 

     
    antibodies-online peptides for MRC2

    MRC2 Antibody Products:

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    antibodies-online antibodies for MRC2 (37 products) 

    MRC2 Assay Products:

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    Cloud-Clone Corp. ELISAs for MRC2
    Cloud-Clone Corp. CLIAs for MRC2
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    antibodies-online kits for MRC2 (15 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    CLEC: C-type lectin domain containing

    Selected InterPro protein domains (see all 7):
     IPR000772 Ricin_B_lectin
     IPR016187 C-type_lectin_fold
     IPR013806 Kringle-like
     IPR018378 C-type_lectin_CS
     IPR000562 FN_type2_col-bd

    Graphical View of Domain Structure for InterPro Entry Q9UBG0

    ProtoNet protein and cluster: Q9UBG0

    3 Blocks protein domains:
    IPB000562 Type II fibronectin collagen-binding domain
    IPB000772 Ricin B lectin domain
    IPB002345 Lipocalin signature


    UniProtKB/Swiss-Prot: MRC2_HUMAN, Q9UBG0
    Domain: C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and
    N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner
    Domain: Fibronectin type-II domain mediates collagen-binding
    Domain: Ricin B-type lectin domain contacts with the second C-type lectin domain (By similarity)
    Similarity: Contains 8 C-type lectin domains
    Similarity: Contains 1 fibronectin type-II domain
    Similarity: Contains 1 ricin B-type lectin domain


    Find genes that share domains with MRC2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRC2_HUMAN, Q9UBG0
    Function: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity.
    Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via
    clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular
    level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular
    uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression
    as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in
    remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI7904248
    GO:0005518collagen binding IDA10636902
    GO:0030246carbohydrate binding IEA--
         
    Find genes that share ontologies with MRC2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MRC2:
     Decreased Salmonella enterica   Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mrc2):
     cellular  hematopoietic system  immune system  normal 

    Find genes that share phenotypes with MRC2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MRC2: Mrc2tm1Cmi Mrc2tm1Bug

       genOway: Develop your customized and physiologically relevant rodent model for MRC2

    miRNA
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    miRTarBase miRNAs that target MRC2:
    hsa-mir-1 (MIRT001355), hsa-mir-16-5p (MIRT051126), hsa-mir-10a-5p (MIRT047526)

    Block miRNA regulation of human, mouse, rat MRC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MRC2 (see all 10):
    hsa-miR-4286 hsa-miR-130a* hsa-miR-183 hsa-miR-23c hsa-miR-133b hsa-miR-766 hsa-miR-133a hsa-miR-23b
    SwitchGear 3'UTR luciferase reporter plasmidMRC2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MRC2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MRC2_HUMAN, Q9UBG0: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    peroxisome2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with MRC2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MRC2 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    2CDK-mediated phosphorylation and removal of Cdc6
    Antigen processing-Cross presentation0.80
    Cross-presentation of soluble exogenous antigens (endosomes)0.80
    3Tuberculosis
    Tuberculosis
    4Phagosome
    Phagosome
    5Phagocytosis of Microbes
    Phagocytosis of Microbes


    Find genes that share SuperPaths with MRC2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MRC2
        Phagocytosis of Microbes

    1 Reactome Pathway for MRC2
        Cross-presentation of soluble exogenous antigens (endosomes)


    2 Kegg Pathways  (Kegg details for MRC2):
        Phagosome
    Tuberculosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRC2
    Interactions:

        GeneGlobe Interaction Network for MRC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for MRC2 (Q9UBG03 ENSP000003075134) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDEL1Q9GZM83, ENSP000003339824I2D: score=2 STRING: ENSP00000333982
    IL10ENSP000004122374STRING: ENSP00000412237
    TGFB1ENSP000002219304STRING: ENSP00000221930
    TGFB2ENSP000003558964STRING: ENSP00000355896
    TGFB3ENSP000002386824STRING: ENSP00000238682
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0030574collagen catabolic process IDA12972549

    Find genes that share ontologies with MRC2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRC2

    1 HMDB Compound for MRC2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for MRC2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 72.5 26 12399458 (5), 16452473 (2), 12856000 (2), 12068012 (2) (see all 7)
    n-acetylglucosamine 38.3 1 12399458 (1)



    Find genes that share compounds with MRC2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MRC2 gene: 
    NM_006039.4  

    Unigene Cluster for MRC2:

    Mannose receptor, C type 2
    Hs.7835  [show with all ESTs]
    Unigene Representative Sequence: NM_006039
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303375(uc002jad.3 uc010ddq.1) ENST00000584265 ENST00000584682
    ENST00000583597(uc002jae.3) ENST00000579432 ENST00000446119(uc002jaf.3)
    ENST00000580916
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MRC2 (see all 10):
    hsa-miR-4286 hsa-miR-130a* hsa-miR-183 hsa-miR-23c hsa-miR-133b hsa-miR-766 hsa-miR-133a hsa-miR-23b
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      QuantiFast Probe-based Assays in human, mouse, rat MRC2

    Additional mRNA sequence: 

    AB014609.2 AF107292.1 AF134838.1 AK093230.1 AK125756.1 AY429551.1 BC032763.1 BC146647.1 
    BC150212.1 BC153884.1 U58856.1 

    14 DOTS entries:

    DT.87016910  DT.95217401  DT.100759316  DT.87016909  DT.120938370  DT.101968204  DT.102832048  DT.101963212 
    DT.120938377  DT.120938379  DT.121626867  DT.40107301  DT.91752958  DT.95276811 

    Selected AceView cDNA sequences (see all 253):

    AI356726 AI138379 AL705478 AI308093 BE677044 AI167943 CB049046 CB049047 
    BU738698 AI049537 AI197982 CA421081 BQ771978 AW073602 BM722134 AW469994 
    AA953297 AW613858 H52232 BC032763 BF438359 AI436099 BQ446914 BG249186 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MRC2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ·
    SP1:                                                                                                                          -     -                 -         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                  -         
    SP4:                                                                                                  -                                                         
    SP5:                                                                                                                                                  -         

    ExUns: 19c ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29
    SP1:        -                                                                                 
    SP2:                                                        -                                 
    SP3:        -                                                                                 
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for MRC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTTTCTC
    MRC2 Expression
    About this image


    MRC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Erythroblasts Hematopoietic Bone Marrow
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Neural Crest (Gastrulation Derivatives)
             Cranial Neural Crest Cells Branchial Arch 1
     
     Bone (Muscoskeletal System)
             Endochondral Facial Bones
     
     Head Mesenchyme (Muscoskeletal System)
             Cranial Neural Crest Cells Branchial Arch 1
    MRC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7835

    UniProtKB/Swiss-Prot: MRC2_HUMAN, Q9UBG0
    Tissue specificity: Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and
    colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MRC2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrc21 , 5 mannose receptor, C type 21, 5 87.86(n)1
    91(a)1
      11 (68.73 cM)5
    175341  NM_008626.31  NP_032652.31 
     1052926435 
    chicken
    (Gallus gallus)
    Aves MRC21 mannose receptor, C type 2 76.35(n)
    74.65(a)
      419950  XM_418071.4  XP_418071.4 
    lizard
    (Anolis carolinensis)
    Reptilia MRC26
    mannose receptor, C type 2
    70(a)
    1 ↔ 1
    6(61635240-61696887)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.19772 Xenopus laevis transcribed sequence with weak similarity more 78.47(n)    BG407202.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mrc21 mannose receptor, C type 2 57.69(n)
    51.56(a)
      100004793  XM_001343974.4  XP_001344010.4 
    worm
    (Caenorhabditis elegans)
    Secernentea clec-506
    clec-486
    (see all 7)
    Protein CLEC-48 (clec-48) mRNA, complete cds
    (see all 7)
    28(a)
    27(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    V(19752401-19755363) WBGene00012253
    V(18158027-18159610) WBGene00007565


    ENSEMBL Gene Tree for MRC2 (if available)
    TreeFam Gene Tree for MRC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MRC2 gene
    LY752  ENSG000001837482  PLA2R12  MRC12  LY75-CD3022  
    7 SIMAP similar genes for MRC2 using alignment to 4 protein entries:     MRC2_HUMAN (see all proteins):
    FCER2    MRC1    MRC1L1    REG1A    PLA2R1    REG1B
    LY75

    Find genes that share paralogs with MRC2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MRC2 (see all 1490)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1178830411,2
    F--60702770(+) TGTCGC/TGCTGG 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs80672411,2
    C,F,H--60702788(+) AGTCTC/TGCGCT 1 -- us2k15Minor allele frequency- T:0.02NS EA WA 538
    rs1457217161,2
    C--60702789(+) GTCTCG/TCGCTG 1 -- us2k10--------
    rs761315261,2
    F--60702791(+) CTCGCG/ACTGGA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1383418051,2
    --60702793(+) CGCGCA/TGGAGG 1 -- us2k10--------
    rs1917819791,2
    --60702846(+) AGCTTA/GAACCA 1 -- us2k10--------
    rs2020925651,2
    --60702863(+) GTCCC-/TGCGAG 1 -- us2k10--------
    rs24654351,2
    C,F--60702882(+) ACTTTC/TGTGCT 1 -- us2k115Minor allele frequency- T:0.01NA WA CSA EA 516
    rs1844127131,2
    --60702883(+) CTTTTA/GTGCTC 1 -- us2k10--------
    rs1403247981,2
    --60702904(+) GCGTCG/TTCTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MRC2 (60704762 - 60770958 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MRC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509664CNV Insertion20534489
    nsv2115CNV Insertion18451855
    nsv470595CNV Loss18288195
    nsv908680CNV Loss21882294
    nsv516921CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRC2
    DNA2.0 Custom Variant and Variant Library Synthesis for MRC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612264    OMIM disorders: --

    1 disease for MRC2:    
    About MalaCards
    breast cancer


    Find genes that share disorders with MRC2           About GenesLikeMe

    2 Novoseek inferred disease relationships for MRC2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoarthritis 11.8 4 14697685 (2), 10782465 (1)
    tumors 0 7 17623673 (1), 20339555 (1), 16465063 (1)

    Genetic Association Database (GAD): MRC2
    Human Genome Epidemiology (HuGE) Navigator: MRC2 (1 document)

    Export disorders for MRC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRC2 gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with MRC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    2. Characterization of a novel member of the macrophage mannose receptor type C lectin family. (PubMed id 8702911)1, 2, 3 Wu K.... Lasky L.A. (J. Biol. Chem. 1996)
    3. Characterization of sugar binding by the mannose receptor family member, Endo180. (PubMed id 12399458)1, 2, 9 East L.... Isacke C.M. (J. Biol. Chem. 2002)
    4. The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family. (PubMed id 12068012)1, 2, 9 Howard M.J. and Isacke C.M. (J. Biol. Chem. 2002)
    5. A urokinase receptor-associated protein with specific collagen binding properties. (PubMed id 10636902)1, 2, 9 Behrendt N....Danoe K. (J. Biol. Chem. 2000)
    6. Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor. (PubMed id 12972549)1, 2, 9 Wienke D.... Isacke C.M. (Mol. Biol. Cell 2003)
    7. Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants. (PubMed id 19584075)1, 4 Wu X....Hong W.K. (Cancer Prev Res (Phila) 2009)
    8. Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor. (PubMed id 10683150)1, 2 Sheikh H.... Isacke C.M. (J. Cell Sci. 2000)
    9. GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis. (PubMed id 12952933)1, 9 Sturge J....Isacke C.M. (J. Cell Biol. 2003)
    10. Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180. (PubMed id 19861500)1, 9 Messaritou G....Yarwood H. (J. Cell. Sci. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9902 HGNC: 16875 AceView: MRC2 Ensembl:ENSG00000011028 euGenes: HUgn9902
    ECgene: MRC2 Kegg: 9902 H-InvDB: MRC2

    (According to HUGE)
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    HUGE: KIAA0709

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRC2 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_251

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRC2 gene:
    Search GeneIP for patents involving MRC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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