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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MRC2 Gene

protein-coding GIFtS: 61
GCID: GC17P060704

mannose receptor, C type 2

Explore 10 diseases affiliated with
MRC2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mannose Receptor, C Type 2¹ ²		Urokinase-Type Plasminogen Activator Receptor-Associated Protein² ³
ENDO180¹ ² ³ ⁵		C-Type Lectin Domain Family 13 Member E² ³
CLEC13E¹ ² ³		UPAR-Associated Protein² ³
CD280¹ ² ⁵		C-Type Mannose Receptor 2²
UPARAP² ³ ⁵		Endocytic Receptor (Macrophage Mannose Receptor Family)²
KIAA0709¹ ³		CD280 Antigen³
Endocytic Receptor 180² ³		Urokinase Receptor-Associated Protein³
Macrophage Mannose Receptor 2² ³

External Ids:	HGNC: 16875¹	Entrez Gene: 9902²	Ensembl: ENSG00000011028⁷	OMIM: 612264⁵	UniProtKB: Q9UBG0³

Export aliases for MRC2 gene to outside databases

Previous GC identifers: GC17P060392 GC17P063131 GC17P061045 GC17P061178 GC17P058058 GC17P056071

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRC2:

This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and

multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating

the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the

tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease.

(provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: MRC2_HUMAN, Q9UBG0

Function: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes

glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated

endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and

thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation

of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue

destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating

with the matrix metalloproteinases (MMPs)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MRC2 gene promoter:
Pax-5 NRSF form 1 MyoD C/EBPalpha NF-AT NF-AT4 NF-AT2 NF-AT3 ATF NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MRC2 promoter sequence

Search SABiosciences Chromatin IP Primers for MRC2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRC2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2 Ensembl cytogenetic band: 17q23.2 HGNC cytogenetic band: 17q23

MRC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRC2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P060704: view genomic region (about GC identifiers)

Start:	60,704,762 bp from pter	End:	60,770,958 bp from pter
Size:	66,197 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MRC2_HUMAN, Q9UBG0 (See protein sequence)

Recommended Name: C-type mannose receptor 2 precursor

Size: 1479 amino acids; 166674 Da

Subunit: Interacts with C-terminal region of type I collagen/COL1A1 (By similarity). Interacts directly with PLAUR/UPAR

and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V

Subcellular location: Membrane; Single-pass type I membrane protein

Sequence caution: Sequence=BAA31684.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: A6H8K4 D3DU08 Q7LGE7 Q9Y5P9

Explore the universe of human proteins at neXtProt for MRC2: NX_Q9UBG0

Post-translational modifications:

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UBG0

MRC2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006030.2

ENSEMBL proteins:

ENSP00000307513 ENSP00000461968 ENSP00000463968 ENSP00000400445

Reactome Protein details: Q9UBG0
Human Recombinant Protein Products:

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	OriGene Purified Protein: MRC2 OriGene Protein Over-expression Lysate: MRC2 OriGene Custom Protein Services for MRC2
	GenScript Custom Purified and Recombinant Proteins Services for MRC2
	Novus Biologicals MRC2 Protein Novus Biologicals MRC2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MRC2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

MRC2 for ontologies About GeneDecksing

MRC2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MRC2
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	Novus Biologicals MRC2 Antibodies
	Search for Antibodies for MRC2 at Abcam
	Uscn Antibodies for MRC2
	Search ThermoFisher Antibodies for MRC2

Assay Products for MRC2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MRC2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MRC2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MRC2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR000772 Ricin_B_lectin

IPR016187 C-type_lectin_fold

IPR013806 Kringle-like

IPR018378 C-type_lectin_CS

IPR000562 FN_type2_col-bd

Graphical View of Domain Structure for InterPro Entry Q9UBG0

ProtoNet protein and cluster: Q9UBG0

3 Blocks protein families:

IPB000562 Type II fibronectin collagen-binding domain

IPB000772 Ricin B lectin domain

IPB002345 Lipocalin signature

UniProtKB/Swiss-Prot: MRC2_HUMAN, Q9UBG0

Domain: C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and

N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner

Domain: Fibronectin type-II domain mediates collagen-binding

Domain: Ricin B-type lectin domain contacts with the second C-type lectin domain (By similarity)

Similarity: Contains 8 C-type lectin domains

Similarity: Contains 1 fibronectin type-II domain

Similarity: Contains 1 ricin B-type lectin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MRC2_HUMAN, Q9UBG0

Function: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes

glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated

endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and

thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation

of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue

destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating

with the matrix metalloproteinases (MMPs)

miRNA Products:		miRTarBase miRNAs that target MRC2: hsa-mir-1 (MIRT001355)

		OriGene 3'-UTR Clone: MRC2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRC2
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MRC2 (see all 10):
		hsa-miR-4286 hsa-miR-130a* hsa-miR-183 hsa-miR-23c hsa-miR-133b hsa-miR-766 hsa-miR-133a hsa-miR-23b

		SwitchGear 3'UTR luciferase reporter plasmid: MRC2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRC2 (see all 7) OriGene shRNA RFP: MRC2 OriGene siRNA: MRC2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRC2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MRC2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRC2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRC2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MRC2 (NM_006039)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRC2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRC2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MRC2
		Search LifeMap BioReagents cell lines for MRC2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRC2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0030246	carbohydrate binding	IEA	--

MRC2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for MRC2:

Decreased Salmonella enterica

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for MRC2: Mrc2^tm1Cmi Mrc2^tm1Bug
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mrc2):

cellular

immune system

normal

MRC2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Ubiquitinated Orc1 is degraded by the proteasome

Cross-presentation of soluble exogenous antigens (endosomes)

0.81

Antigen processing-Cross presentation

0.60

Phagocytosis of Microbes

Phagocytosis of Microbes

1.00

Tuberculosis

Tuberculosis

1.00

Phagosome

Phagosome

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MRC2

Phagocytosis of Microbes

5 Reactome Pathways for MRC2

	Antigen processing-Cross presentation
	Cross-presentation of soluble exogenous antigens (endosomes)
	Adaptive Immune System
	Class I MHC mediated antigen processing & presentation
	Immune System

2 Kegg Pathways (Kegg details for MRC2):

	Phagosome
	Tuberculosis

MRC2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MRC2

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/6 Interacting proteins for MRC2 (Q9UBG0³ ENSP00000307513⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NDEL1	Q9GZM8³, ENSP00000333982⁴	I2D: score=2 STRING: ENSP00000333982
IL10	ENSP00000412237⁴	STRING: ENSP00000412237
TGFB1	ENSP00000221930⁴	STRING: ENSP00000221930
TGFB2	ENSP00000355896⁴	STRING: ENSP00000355896
TGFB3	ENSP00000238682⁴	STRING: ENSP00000238682

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006897	endocytosis	IEA	--

MRC2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MRC2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MRC2

1 HMDB Compound for MRC2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

2 Novoseek chemical compound relationships for MRC2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mannose	72.5	26	12399458 (5), 16452473 (2), 12856000 (2), 12068012 (2) (see all 7)
n-acetylglucosamine	38.3	1	12399458 (1)

Search CenterWatch for drugs/clinical trials and news about MRC2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MRC2 gene:

NM_006039.4

Unigene Cluster for MRC2:

Mannose receptor, C type 2

Hs.7835 [show with all ESTs]

Unigene Representative Sequence: NM_006039

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000303375(uc002jad.3 uc010ddq.1) ENST00000584265 ENST00000584682

ENST00000583597(uc002jae.3) ENST00000579432 ENST00000446119(uc002jaf.3)

ENST00000580916

miRNA Products:		OriGene 3'-UTR Clone: MRC2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRC2
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MRC2 (see all 10):
		hsa-miR-4286 hsa-miR-130a* hsa-miR-183 hsa-miR-23c hsa-miR-133b hsa-miR-766 hsa-miR-133a hsa-miR-23b

		SwitchGear 3'UTR luciferase reporter plasmid: MRC2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRC2 (see all 7) OriGene shRNA RFP: MRC2 OriGene siRNA: MRC2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRC2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRC2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRC2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MRC2 (NM_006039)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRC2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRC2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRC2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MRC2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRC2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRC2

Additional cDNA sequence:

AB014609.2 AF107292.1 AF134838.1 AK093230.1 AK125756.1 AY429551.1 BC032763.1 BC146647.1

BC150212.1 BC153884.1 U58856.1

14 DOTS entries:

DT.87016910 DT.95217401 DT.100759316 DT.87016909 DT.120938370 DT.101968204 DT.102832048 DT.101963212

DT.120938377 DT.120938379 DT.121626867 DT.40107301 DT.91752958 DT.95276811

24/253 AceView cDNA sequences (see all 253):

AA603954 AI361540 AI197982 AI436099 BQ446914 BU738698 BQ574763 AI635223

AY429551 AI624160 AW873013 AI167943 BE855549 BM678460 AK093230 BF438359

AW102791 AI540540 AI356726 BU620740 AW168491 BG059691 CB049047 AW263307

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MRC2 (see all 8) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17a	·	17b	·	17c	^	18	^	19a	·	19b	·
SP1:																																									-		-						-
SP2:
SP3:																																																	-
SP4:																																	-
SP5:																																																	-

ExUns:	19c	^	20	^	21a	·	21b	·	21c	^	22a	·	22b	^	23	^	24	^	25	^	26a	·	26b	^	27	^	28	^	29
SP1:			-
SP2:																			-
SP3:			-
SP4:
SP5:

ECgene alternative splicing isoforms for MRC2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MRC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCTTTCTC

About this image

MRC2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Branchial Arch 1

Cranial Neural Crest Cells

Neural Crest

Head Mesenchyme

Branchial Arch 1

Paraxial Mesoderm Cells

Bone, Skeletal Muscle

Bone

Endochondral Facial Bones

Bone

Brain

Meninges

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (A scalable, suspensi...)

See MRC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRC2

SOURCE GeneReport for Unigene cluster: Hs.7835

UniProtKB/Swiss-Prot: MRC2_HUMAN, Q9UBG0

Tissue specificity: Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and

colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney

SABiosciences Custom PCR Arrays for MRC2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRC2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MRC2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRC2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRC2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRC2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MRC2 gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MRC2¹	mannose receptor, C type 2	75.84(n) 73.77(a)		419950 XM_418071.3 XP_418071.3
lizard (Anolis carolinensis)	Reptilia	MRC2⁶	--	71(a)	1 ↔ 1	6(61632426-61684679)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1977²	Xenopus laevis transcribed sequence with weak similarity more	78.47(n)		BG407202.1
zebrafish (Danio rerio)	Actinopterygii	mrc2¹	mannose receptor, C type 2	58.68(n) 52.44(a)		100004793 XM_001343974.3 XP_001344010.3
worm (Caenorhabditis elegans)	Secernentea	clec-178⁶	C-type LECtin family member (clec-178)	20(a)	possible ortholog	IV(5653976-5654993)

ENSEMBL Gene Tree for MRC2 (if available)
TreeFam Gene Tree for MRC2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MRC2 gene

LY75² ENSG00000183748² PLA2R1² MRC1² LY75-CD302²

8 SIMAP similar genes for MRC2 using alignment to 4 protein entries: MRC2_HUMAN (see all proteins):

FCER2 MRC1 MRC1L1 REG1A PLA2R1 REG1B

LY75 DKFZp686H17246

MRC2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11297640^1,2	C,	--	56109819(+)	`TCTGTC/-CCCCC`	1	--	int¹ trp³		1		NA	2
rs117883041^1,2		--	60702770(+)	`TGTCGC/TGCTGG`	1	--	us2k¹		1		NA	120
rs8067241^1,2	C,F,H,	--	60702788(+)	`AGTCTC/TGCGCT`	1	--	us2k¹		5		NS EA WA	538
rs145721716^1,2		--	60702789(+)	`GTCTCG/TCGCTG`	1	--	us2k¹		0	--	--	--	--
rs76131526^1,2	F,	--	60702791(+)	`CTCGCG/ACTGGA`	1	--	us2k¹		1		WA	118
rs138341805^1,2		--	60702793(+)	`CGCGCA/TGGAGG`	1	--	us2k¹		0	--	--	--	--
rs191781979^1,2		--	60702846(+)	`AGCTTA/GAACCA`	1	--	us2k¹		0	--	--	--	--
rs202092565^1,2		--	60702863(+)	`GTCCC-/TGCGAG`	1	--	us2k¹		0	--	--	--	--
rs2465435^1,2	C,F,	--	60702882(+)	`ACTTTC/TGTGCT`	1	--	us2k¹		15		NA WA CSA EA	516
rs184412713^1,2		--	60702883(+)	`CTTTTA/GTGCTC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MRC2 (60704762 - 60770958 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MRC2
1 CNV: 49907

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MRC2 for disorders           About GeneDecksing

OMIM gene information: 612264    OMIM disorders: --

10 diseases for MRC2:    About MalaCards

breast cancer aortic aneurysm prostate cancer, progression of osteoarthritis

prostate cancer prostatitis schizophrenia tuberculosis

immunodeficiency hepatitis

2 Novoseek disease relationships for MRC2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
osteoarthritis	11.8	4	14697685 (2), 10782465 (1)
tumors	0	7	17623673 (1), 20339555 (1), 16465063 (1)

Human Genome Epidemiology (HuGE) Navigator: MRC2 (1 document)

Export disorders for MRC2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MRC2 gene, integrated from 9 sources (see all 63):
(articles sorted by number of sources associating them with MRC2)

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Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{1, 2, 3} Ishikawa K.... Ohara O. (1998)
Characterization of a novel member of the macrophage mannose receptor type C lectin family. (PubMed id 8702911)^{1, 2, 3} Wu K.... Lasky L.A. (1996)
Characterization of sugar binding by the mannose receptor family member, Endo180. (PubMed id 12399458)^{1, 2, 9} East L.... Isacke C.M. (2002)
The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family. (PubMed id 12068012)^{1, 2, 9} Howard M.J. and Isacke C.M. (2002)
A urokinase receptor-associated protein with specific collagen binding properties. (PubMed id 10636902)^{1, 2, 9} Behrendt N....Danoe K. (2000)
Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor. (PubMed id 12972549)^{1, 2, 9} Wienke D.... Isacke C.M. (2003)
Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor. (PubMed id 10683150)^{1, 2} Sheikh H.... Isacke C.M. (2000)
GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis. (PubMed id 12952933)^{1, 9} Sturge J....Isacke C.M. (2003)
Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180. (PubMed id 19861500)^{1, 9} Messaritou G....Yarwood H. (2009)
Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor. (PubMed id 11903048)^{1, 9} Bailey L....Murphy G. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9902	HGNC: 16875	AceView: MRC2	Ensembl:ENSG00000011028	euGenes: HUgn9902
ECgene: MRC2	Kegg: 9902	H-InvDB: MRC2

(According to HUGE)
About This Section

HUGE: KIAA0709

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MRC2	Pharmacogenomics, SNPs, Pathways
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_251

Intellectual Property for MRC2 gene
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Patent Information for MRC2 gene:
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GeneCards and IP:
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mannose receptor, C type 2

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