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MRC1 Gene

protein-coding   GIFtS: 58
GCID: GC10P018098

Mannose Receptor, C Type 1

(Previous names: mannose receptor, C type 1-like 1)
(Previous symbol: MRC1L1)
  See MRC1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mannose Receptor, C Type 11 2     C-Type Lectin Domain Family 13 Member D2 3
MRC1L11 2 3     CD2062
MMR2 3 5     bA541I19.12
Mannose Receptor, C Type 1-Like 11 2     Macrophage Mannose Receptor 12
Macrophage Mannose Receptor 1-Like Protein 12 3     C-Type Lectin Domain Family 13 Member D-Like3
CLEC13D2 3     CD206 Antigen3
CLEC13DL2 3     

External Ids:    HGNC: 72281   Entrez Gene: 43602   Ensembl: ENSG000001205867   OMIM: 1536185   UniProtKB: P228973   

Export aliases for MRC1 gene to outside databases

Previous GC identifers: GC10P017833 GC10P018248 GC10P018102 GC10P018138


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRC1 Gene:
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological
processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The
protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by
macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic
viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.(provided by RefSeq, Apr
2011)

GeneCards Summary for MRC1 Gene:
MRC1 (mannose receptor, C type 1) is a protein-coding gene. Diseases associated with MRC1 include klebsiella, and gaucher's disease. GO annotations related to this gene include receptor activity and mannose binding. An important paralog of this gene is LY75.

UniProtKB/Swiss-Prot: MRC1_HUMAN, P22897
Function: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated
polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_018921.2  NC_000010.10  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRC1 gene promoter:
         MEF-2   Olf-1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   C/EBPalpha   AREB6   MEF-2A   HSF2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRC1 promoter sequence
   Search Chromatin IP Primers for MRC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.33   Ensembl cytogenetic band:  10p12.33   HGNC cytogenetic band: 10p13

MRC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRC1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P018098:  view genomic region     (about GC identifiers)

Start:
18,098,352 bp from pter      End:
18,200,091 bp from pter
Size:
101,740 bases      Orientation:
plus strand

1 alternative location:
Chr10+,NW_003315932 238,154-339,953     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MRC1_HUMAN, P22897 (See protein sequence)
Recommended Name: Macrophage mannose receptor 1 precursor  
Size: 1456 amino acids; 166012 Da
Miscellaneous: CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding
and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high
affinity binding and endocytosis of multivalent glycoconjugates
Sequence caution: Sequence=CAH70733.1; Type=Erroneous gene model prediction; Sequence=CAH70872.1; Type=Erroneous
gene model prediction; Sequence=CAH71176.1; Type=Erroneous gene model prediction; Sequence=CAI15339.1;
Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for MRC1:
1EGG (3D)        1EGI (3D)    
Secondary accessions: A5PKW3 Q5VSJ2 Q5VSK2
Alternative splicing: 2 isoforms:  P22897-1   P22897-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MRC1: NX_P22897

Explore proteomics data for MRC1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn104, Asn344, Asn529, Asn926, Asn930, Asn1160, Asn1205
  • Modification sites at PhosphoSitePlus

  • See MRC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002429.1  
    ENSEMBL proteins: 
     ENSP00000239761  
    Reactome Protein details: P22897

    MRC1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MRC1

     
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    antibodies-online proteins for MRC1 (3 products) 

     
    antibodies-online peptides for MRC1

    MRC1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    antibodies-online antibodies for MRC1 (58 products) 

    MRC1 Assay Products:

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    Cloud-Clone Corp. ELISAs for MRC1
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    CLEC: C-type lectin domain containing

    Selected InterPro protein domains (see all 7):
     IPR000772 Ricin_B_lectin
     IPR016187 C-type_lectin_fold
     IPR013806 Kringle-like
     IPR018378 C-type_lectin_CS
     IPR000562 FN_type2_col-bd

    Graphical View of Domain Structure for InterPro Entry P22897

    ProtoNet protein and cluster: P22897

    2 Blocks protein domains:
    IPB000562 Type II fibronectin collagen-binding domain
    IPB000772 Ricin B lectin domain


    UniProtKB/Swiss-Prot: MRC1_HUMAN, P22897
    Similarity: Contains 8 C-type lectin domains
    Similarity: Contains 1 fibronectin type-II domain
    Similarity: Contains 1 ricin B-type lectin domain


    Find genes that share domains with MRC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRC1_HUMAN, P22897
    Function: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated
    polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens

         Genatlas biochemistry entry for MRC1:
    mannose receptor C,type 1,expressed in macrophage,endothelial cells,binding oligosaccharides

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IDA--
    GO:0005515protein binding IPI11222859
    GO:0005537mannose binding TAS2373685
    GO:0030246carbohydrate binding ----
         
    Find genes that share ontologies with MRC1           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mrc1):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  reproductive system 

    Find genes that share phenotypes with MRC1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mrc1tm1Jub for MRC1

       genOway: Develop your customized and physiologically relevant rodent model for MRC1

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MRC1 (see all 11):
    hsa-miR-130a* hsa-miR-522 hsa-miR-491-3p hsa-miR-23c hsa-miR-224* hsa-miR-511 hsa-miR-23b hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidMRC1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MRC1
    Predesigned siRNA for gene silencing in human, mouse, rat MRC1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MRC1 (NM_002438)
    Sino Biological Human cDNA Clone for MRC1
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MRC1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MRC1_HUMAN, P22897: Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    extracellular2
    cytosol1
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--
    GO:0005887integral component of plasma membrane TAS1294118
    GO:0010008endosome membrane IDA--

    Find genes that share ontologies with MRC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MRC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    2CDK-mediated phosphorylation and removal of Cdc6
    Antigen processing-Cross presentation0.80
    Cross-presentation of soluble exogenous antigens (endosomes)0.80
    3Tuberculosis
    Tuberculosis
    4Phagosome
    Phagosome
    5Phagocytosis of Microbes
    Phagocytosis of Microbes


    Find genes that share SuperPaths with MRC1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MRC1
        Phagocytosis of Microbes


    1 Reactome Pathway for MRC1
        Cross-presentation of soluble exogenous antigens (endosomes)


    2 Kegg Pathways  (Kegg details for MRC1):
        Phagosome
    Tuberculosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MRC1: 
              Antifungal Response in human mouse rat
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MRC1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for MRC1 (P228973 ENSP000002397614) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHEK2O960173, ENSP000003720234I2D: score=1 STRING: ENSP00000372023
    BTKQ061873I2D: score=2 
    MAPK14Q165393I2D: score=2 
    PTPRCP085753I2D: score=1 
    SIGLEC1Q9BZZ23I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006898receptor-mediated endocytosis IDA--

    Find genes that share ontologies with MRC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRC1

    9 Novoseek inferred chemical compound relationships for MRC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 93.9 176 1903183 (4), 12566862 (4), 7868247 (4), 10683150 (3) (see all 99)
    mannan 86.8 5 7868255 (1), 11721968 (1), 7594549 (1), 19380112 (1)
    carbohydrates 47.5 3 11721968 (1), 8359512 (1)
    polysaccharide 42.7 6 18790466 (1), 17524049 (1)
    ricin 36.7 1 16441238 (1)
    galactose 18.1 2 19456233 (1)
    lysine 0 1 9020093 (1)
    nitric oxide 0 1 11204150 (1)
    superoxide 0 1 7806044 (1)



    Find genes that share compounds with MRC1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MRC1 gene (2 alternative transcripts): 
    NM_001009567.1  NM_002438.3  

    Unigene Cluster for MRC1:

    Mannose receptor, C type 1
    Hs.75182  [show with all ESTs]
    Unigene Representative Sequence: J05550
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000239761(uc001ipm.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MRC1 (see all 11):
    hsa-miR-130a* hsa-miR-522 hsa-miR-491-3p hsa-miR-23c hsa-miR-224* hsa-miR-511 hsa-miR-23b hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidMRC1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK128766.1 AK297044.1 AK308132.1 AK308167.1 BC016003.1 BC142642.1 BC146838.1 DQ663787.1 
    J05550.1 X55635.1 

    10 DOTS entries:

    DT.443385  DT.100752003  DT.101972721  DT.121225651  DT.91717457  DT.121225419  DT.91717423  DT.91948385 
    DT.95153494  DT.95153496 

    Selected AceView cDNA sequences (see all 65):

    BM992752 T27627 AA758077 AA705679 BM680134 BM992680 CR601686 BX114787 
    BG542558 CA444230 AA358032 AA043388 AI337585 BX645193 BM724899 BG547467 
    T16252 AL545341 BG537060 BG541717 AI539173 BI759549 H40026 BF435218 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAGAAGAA
    MRC1 Expression
    About this image


    MRC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hindlimb Dorsal Muscle
     
     Bone (Muscoskeletal System)
             Bone marrow-derived mesenchymal stem cells and monocytes (Ixmyelocel-T)
     
     Heart (Cardiovascular System)
             Primitive Heart Tube Cells Primitive Heart Tube
    MRC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75182
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MRC1: 
              Antifungal Response in human mouse rat
              Allergy & Asthma in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MRC1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrc11 , 5 mannose receptor, C type 11, 5 82.25(n)1
    82.06(a)1
      2 (10.46 cM)5
    175331  NM_008625.21  NP_032651.21 
     142294145 
    chicken
    (Gallus gallus)
    Aves LOC4205161 macrophage mannose receptor 1-like 67.59(n)
    63.04(a)
      420516  XM_418618.3  XP_418618.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    58(a)
    49(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    6(18062808-18115005)
    6(17965812-18008887)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mrc11 mannose receptor, C type 1 62.16(n)
    55.44(a)
      100493504  XM_002939002.2  XP_002939048.2 
    zebrafish
    (Danio rerio)
    Actinopterygii mrc1a1 mannose receptor, C type 1a 57.18(n)
    51.52(a)
      100286774  XM_002662968.2  XP_002663014.2 
    worm
    (Caenorhabditis elegans)
    Secernentea clec-536
    clec-526
    (see all 7)
    Protein CLEC-52 (clec-52) mRNA, complete cds
    (see all 7)
    27(a)
    26(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    I(3871471-3873416) WBGene00020191
    IV(8167163-8168774) WBGene00015052


    ENSEMBL Gene Tree for MRC1 (if available)
    TreeFam Gene Tree for MRC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MRC1 gene
    LY752  ENSG000001837482  PLA2R12  LY75-CD3022  MRC22  
    4 SIMAP similar genes for MRC1 using alignment to 2 protein entries:     MRC1_HUMAN (see all proteins):
    MRC1L1    MRC2    REG1B    REG1A

    Find genes that share paralogs with MRC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    MRC1_HUMAN, P22897: Genetic variations in MRC1 may influence susceptibility or resistance to leprosy in some
    populations. Particularly, Gly-396 seems to be a risk factor for leprosy when associated with Ala-399 and Phe-407


    Selected SNPs for MRC1 (see all 199)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs24776461,2
    C--17770283(-) GAAGAG/CGCTTC 1 -- int12Minor allele frequency- C:0.25NA 4
    rs24611441,2
    C,F--17770296(-) TCCCAT/AGTCAG 1 -- int14Minor allele frequency- A:0.43NA CSA 7
    rs561903851,2
    C--17770296(-) TCCCAA/TGTCAG 1 -- int10--------
    rs341799561,2
    C--17788565(+) AAAAA-/AGTAGA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs29858371,2
    C,O--17788791(+) CACCAG/AGCGAG 3 /H /Q mis12Minor allele frequency- A:0.25NA 4
    rs24776611,2
    C--17788886(-) ACTTGA/CGACTT 1 -- int10--------
    rs24611651,2
    C--17791297(-) CATCAT/CATTGC 1 -- int14Minor allele frequency- C:0.22NA 186
    rs24611641,2
    C--17791319(-) TAAGAC/TTATGA 1 -- int15Minor allele frequency- T:0.37NA EA 364
    rs558658001,2
    C--17791319(-) TAAGAC/TTATGA 1 -- int10--------
    rs24776521,2
    C--17791611(-) TGGTGG/AGAATA 1 -- int11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for MRC1 (18098352 - 18200091 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MRC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674193CNV Deletion23128226
    nsv508572CNV Loss20534489
    esv29303CNV Loss19812545
    nsv894913CNV Loss21882294
    esv25021CNV Loss19812545
    esv33746CNV Gain17666407

    Human Gene Mutation Database (HGMD): MRC1
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MRC1
    DNA2.0 Custom Variant and Variant Library Synthesis for MRC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 153618    OMIM disorders: --

    2 diseases for MRC1:    
    About MalaCards
    klebsiella    gaucher's disease


    Find genes that share disorders with MRC1           About GenesLikeMe

    3 Novoseek inferred disease relationships for MRC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gaucher disease 43.4 1 17524049 (1)
    tuberculosis 34.1 5 16203868 (1), 7594549 (1), 16238626 (1), 19318518 (1) (see all 5)
    inflammation 13.2 4 18790466 (1), 8780401 (1)

    Genetic Association Database (GAD): MRC1
    Human Genome Epidemiology (HuGE) Navigator: MRC1 (5 documents)

    Export disorders for MRC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRC1 gene, integrated from 10 sources (see all 176):
    (articles sorted by number of sources associating them with MRC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Organization of the gene encoding the human macrophage mannose receptor (MRC1). (PubMed id 1294118)1, 2, 3, 9 Kim S.J.... Drickamer K. (Genomics 1992)
    2. Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility. (PubMed id 20035344)1, 2, 4 Alter A.... Schurr E. (Hum. Genet. 2010)
    3. Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor. (PubMed id 1730714)1, 2, 9 Taylor M.E.... Drickamer K. (J. Biol. Chem. 1992)
    4. Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. (PubMed id 2258707)1, 2, 9 Ezekowitz R.A.... Warner A. (J. Exp. Med. 1990)
    5. Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor. (PubMed id 10779515)1, 2, 9 Feinberg H....Weis W.I. (J. Biol. Chem. 2000)
    6. Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. (PubMed id 21943158)1, 4 Middelberg R.P....Whitfield J.B. (BMC Med. Genet. 2011)
    7. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PubMed id 20139978)1, 4 Kamatani Y....Kamatani N. (Nat. Genet. 2010)
    8. Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis. (PubMed id 21029423)1, 4 Hattori T....Nishimura M. (BMC Med. Genet. 2010)
    9. Genetic variants in the mannose receptor gene (MRC1) are associated with asthma in two independent populations. (PubMed id 19902202)1, 4 Hattori T....Nishimura M. (Immunogenetics 2009)
    10. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4360 HGNC: 7228 AceView: MRC1.1 Ensembl:ENSG00000120586 euGenes: HUgn4360
    ECgene: MRC1 Kegg: 4360 H-InvDB: MRC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MRC1 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_00127

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRC1 gene:
    Search GeneIP for patents involving MRC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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