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Aliases for MRC1 Gene

Aliases for MRC1 Gene

  • Mannose Receptor, C Type 1 2 3
  • MMR 3 4 6
  • Macrophage Mannose Receptor 1-Like Protein 1 3 4
  • C-Type Lectin Domain Family 13 Member D 3 4
  • Mannose Receptor, C Type 1-Like 1 2 3
  • CLEC13DL 3 4
  • CLEC13D 3 4
  • MRC1L1 3 4
  • C-Type Lectin Domain Family 13 Member D-Like 4
  • Macrophage Mannose Receptor 1 3
  • CD206 Antigen 4
  • BA541I19.1 3
  • CD206 3

External Ids for MRC1 Gene

Previous HGNC Symbols for MRC1 Gene

  • MRC1L1

Previous GeneCards Identifiers for MRC1 Gene

  • GC10P018248
  • GC10P018102
  • GC10P018138
  • GC10P018098

Summaries for MRC1 Gene

Entrez Gene Summary for MRC1 Gene

  • The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Apr 2011]

GeneCards Summary for MRC1 Gene

MRC1 (Mannose Receptor, C Type 1) is a Protein Coding gene. Diseases associated with MRC1 include gaucher's disease. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include receptor activity and mannose binding.

UniProtKB/Swiss-Prot for MRC1 Gene

  • Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRC1 Gene

Genomics for MRC1 Gene

Genomic Location for MRC1 Gene

Start:
17,809,343 bp from pter
End:
17,911,170 bp from pter
Size:
101,828 bases
Orientation:
Plus strand

Genomic View for MRC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRC1 Gene

Proteins for MRC1 Gene

  • Protein details for MRC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22897-MRC1_HUMAN
    Recommended name:
    Macrophage mannose receptor 1
    Protein Accession:
    P22897
    Secondary Accessions:
    • A5PKW3
    • Q5VSJ2
    • Q5VSK2

    Protein attributes for MRC1 Gene

    Size:
    1456 amino acids
    Molecular mass:
    166012 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates
    SequenceCaution:
    • Sequence=CAH70733.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH70872.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH71176.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15339.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRC1 Gene

    Alternative splice isoforms for MRC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRC1 Gene

Proteomics data for MRC1 Gene at MOPED

Post-translational modifications for MRC1 Gene

  • Glycosylation at Asn104, Asn344, Asn529, Asn926, Asn930, Asn1160, and Asn1205
  • Modification sites at PhosphoSitePlus

Other Protein References for MRC1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MRC1 (MRC1)

No data available for DME Specific Peptides for MRC1 Gene

Domains for MRC1 Gene

Gene Families for MRC1 Gene

HGNC:
  • CD :CD molecules
  • CLEC :C-type lectin domain containing

Suggested Antigen Peptide Sequences for MRC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22897

UniProtKB/Swiss-Prot:

MRC1_HUMAN :
  • P22897
Domain:
  • Contains 8 C-type lectin domains.
  • Contains 1 fibronectin type-II domain.
  • Contains 1 ricin B-type lectin domain.
genes like me logo Genes that share domains with MRC1: view

Function for MRC1 Gene

Molecular function for MRC1 Gene

GENATLAS Biochemistry: mannose receptor C,type 1,expressed in macrophage,endothelial cells,binding oligosaccharides
UniProtKB/Swiss-Prot Function: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens

Gene Ontology (GO) - Molecular Function for MRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 20035344
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005515 protein binding IPI 11222859
GO:0005537 mannose binding IEA --
genes like me logo Genes that share ontologies with MRC1: view
genes like me logo Genes that share phenotypes with MRC1: view

Animal Models for MRC1 Gene

MGI Knock Outs for MRC1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MRC1 Gene

Localization for MRC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRC1 Gene

Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRC1 Gene COMPARTMENTS Subcellular localization image for MRC1 gene
Compartment Confidence
endosome 5
plasma membrane 5
extracellular 2
cytosol 1
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 20035344
GO:0005887 integral component of plasma membrane TAS 1294118
GO:0009986 cell surface IEA --
GO:0010008 endosome membrane IDA 20035344
genes like me logo Genes that share ontologies with MRC1: view

Pathways for MRC1 Gene

genes like me logo Genes that share pathways with MRC1: view

PCR Array Products

Interacting Proteins for MRC1 Gene

Selected Interacting proteins: P22897-MRC1_HUMAN for MRC1 Gene via I2D

Gene Ontology (GO) - Biological Process for MRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IDA 20035344
GO:0007165 signal transduction IEA --
GO:0071222 cellular response to lipopolysaccharide IEA --
GO:0071346 cellular response to interferon-gamma IEA --
GO:0071353 cellular response to interleukin-4 IEA --
genes like me logo Genes that share ontologies with MRC1: view

Compounds for MRC1 Gene

(9) Novoseek inferred chemical compound relationships for MRC1 Gene

Compound -log(P) Hits PubMed IDs
mannose 93.9 128
mannan 86.8 4
carbohydrates 47.5 2
polysaccharide 42.7 2
ricin 36.7 1
genes like me logo Genes that share compounds with MRC1: view

Transcripts for MRC1 Gene

mRNA/cDNA for MRC1 Gene

(65) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRC1 Gene

Mannose receptor, C type 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRC1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MRC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRC1 Gene

No ASD Table

Relevant External Links for MRC1 Gene

GeneLoc Exon Structure for
MRC1
ECgene alternative splicing isoforms for
MRC1

Expression for MRC1 Gene

mRNA expression in normal human tissues for MRC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MRC1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (6.9) and Lung (6.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MRC1 Gene

SOURCE GeneReport for Unigene cluster for MRC1 Gene Hs.75182

genes like me logo Genes that share expressions with MRC1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MRC1 Gene

Orthologs for MRC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRC1 35
  • 99.04 (n)
  • 99.45 (a)
cow
(Bos Taurus)
Mammalia MRC1 35
  • 87.18 (n)
  • 87.36 (a)
dog
(Canis familiaris)
Mammalia MRC1 35
  • 87.89 (n)
  • 88.9 (a)
mouse
(Mus musculus)
Mammalia Mrc1 35
  • 82.25 (n)
  • 82.06 (a)
Mrc1 16
rat
(Rattus norvegicus)
Mammalia Mrc1 35
  • 81.7 (n)
  • 83.44 (a)
chicken
(Gallus gallus)
Aves LOC420516 35
  • 67.59 (n)
  • 63.04 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrc1 35
  • 62.16 (n)
  • 55.44 (a)
zebrafish
(Danio rerio)
Actinopterygii mrc1a 35
  • 57.18 (n)
  • 51.52 (a)
Species with no ortholog for MRC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRC1 Gene

ENSEMBL:
Gene Tree for MRC1 (if available)
TreeFam:
Gene Tree for MRC1 (if available)

Paralogs for MRC1 Gene

Selected SIMAP similar genes for MRC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MRC1: view

No data available for Paralogs for MRC1 Gene

Variants for MRC1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MRC1 Gene

P22897-MRC1_HUMAN
Genetic variations in MRC1 may influence susceptibility or resistance to leprosy in some populations. Particularly, Gly-396 seems to be a risk factor for leprosy when associated with Ala-399 and Phe-407

Sequence variations from dbSNP and Humsavar for MRC1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs482272 -- 17,847,790(+) AATAT(G/T)TTTAA intron-variant
rs506524 -- 17,840,863(-) TCTTC(A/G)GGGCG intron-variant
rs514707 -- 17,879,917(+) ATCAG(A/G)CAAGA intron-variant
rs522417 -- 17,853,688(-) CGTAG(C/T)TGTAA intron-variant
rs526361 -- 17,886,618(+) ggtgg(C/T)ctcca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRC1 Gene

Variant ID Type Subtype PubMed ID
esv2674193 CNV Deletion 23128226
esv29303 CNV Loss 19812545
esv33746 CNV Gain 17666407
nsv508572 CNV Loss 20534489
esv25021 CNV Loss 19812545
nsv894913 CNV Loss 21882294

Relevant External Links for MRC1 Gene

HapMap Linkage Disequilibrium report
MRC1
Human Gene Mutation Database (HGMD)
MRC1

Disorders for MRC1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MRC1 Gene including...

Search for MRC1 Gene in MalaCards »

(3) Novoseek inferred disease relationships for MRC1 Gene

Disease -log(P) Hits PubMed IDs
gaucher disease 43.4 1
tuberculosis 34.1 5
inflammation 13.2 2

Relevant External Links for MRC1

Genetic Association Database (GAD)
MRC1
Human Genome Epidemiology (HuGE) Navigator
MRC1
genes like me logo Genes that share disorders with MRC1: view

No data available for UniProtKB/Swiss-Prot for MRC1 Gene

Publications for MRC1 Gene

  1. Organization of the gene encoding the human macrophage mannose receptor (MRC1). (PMID: 1294118) Kim S.J. … Drickamer K. (Genomics 1992) 2 3 4 23
  2. Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. (PMID: 2258707) Ezekowitz R.A. … Warner A. (J. Exp. Med. 1990) 3 4 23
  3. Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor. (PMID: 10779515) Feinberg H. … Weis W.I. (J. Biol. Chem. 2000) 3 4 23
  4. Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor. (PMID: 1730714) Taylor M.E. … Drickamer K. (J. Biol. Chem. 1992) 3 4 23
  5. Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility. (PMID: 20035344) Alter A. … Schurr E. (Hum. Genet. 2010) 3 4 48

Products for MRC1 Gene

Sources for MRC1 Gene

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