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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRC1 Gene

protein-coding   GIFtS: 59
GCID: GC10P018098

Mannose Receptor, C Type 1

(Previous names: mannose receptor, C type 1-like 1)
(Previous symbol: MRC1L1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mannose Receptor, C Type 11 2     C-Type Lectin Domain Family 13 Member D2 3
MRC1L11 2 3     CD2062
MMR2 3 5     bA541I19.12
Mannose Receptor, C Type 1-Like 11 2     Macrophage Mannose Receptor 12
Macrophage Mannose Receptor 1-Like Protein 12 3     C-Type Lectin Domain Family 13 Member D-Like3
CLEC13D2 3     CD206 Antigen3
CLEC13DL2 3     

External Ids:    HGNC: 72281   Entrez Gene: 43602   Ensembl: ENSG000001205867   OMIM: 1536185   UniProtKB: P228973   

Export aliases for MRC1 gene to outside databases

Previous GC identifers: GC10P017833 GC10P018248 GC10P018102 GC10P018138


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRC1 Gene:
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological
processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The
protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by
macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic
viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.(provided by RefSeq, Apr
2011)

GeneCards Summary for MRC1 Gene: 
MRC1 (mannose receptor, C type 1) is a protein-coding gene. Diseases associated with MRC1 include chickenpox, and klebsiella, and among its related super-pathways are ER-Phagosome pathway and Immune System. GO annotations related to this gene include receptor activity and mannose binding. An important paralog of this gene is LY75.

UniProtKB/Swiss-Prot: MRC1_HUMAN, P22897
Function: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated
polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRC1 gene promoter:
         MEF-2   Olf-1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   C/EBPalpha   AREB6   MEF-2A   HSF2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.33   Ensembl cytogenetic band:  10p12.33   HGNC cytogenetic band: 10p13

MRC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRC1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P018098:  view genomic region     (about GC identifiers)

Start:
18,098,352 bp from pter      End:
18,200,091 bp from pter
Size:
101,740 bases      Orientation:
plus strand

2 alternative locations:
Chr10+,NW_003315932 238,154-339,953      Chr10+ 17,851,362-17,953,178     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MRC1_HUMAN, P22897 (See protein sequence)
Recommended Name: Macrophage mannose receptor 1 precursor  
Size: 1456 amino acids; 166012 Da
Subcellular location: Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I
membrane protein
Miscellaneous: CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding
and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high
affinity binding and endocytosis of multivalent glycoconjugates
Sequence caution: Sequence=CAH70733.1; Type=Erroneous gene model prediction; Sequence=CAH70872.1; Type=Erroneous
gene model prediction; Sequence=CAH71176.1; Type=Erroneous gene model prediction; Sequence=CAI15339.1;
Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for MRC1:
1EGG (3D)        1EGI (3D)    
Secondary accessions: A5PKW3 Q5VSJ2 Q5VSK2
Alternative splicing: 2 isoforms:  P22897-1   P22897-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MRC1: NX_P22897

Explore proteomics data for MRC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22897

  • MRC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MRC1 Protein Expression
    REFSEQ proteins: NP_002429.1  
    ENSEMBL proteins: 
     ENSP00000239761  
    Reactome Protein details: P22897
    Human Recombinant Protein Products for MRC1: 
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    Novus Biologicals MRC1 Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MRC1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--
    GO:0005887integral to plasma membrane TAS1294118
    GO:0010008endosome membrane IDA--

    MRC1 for ontologies           About GeneDecksing



    MRC1 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for MRC1 
    Cloud-Clone Corp. CLIAs for MRC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    CLEC: C-type lectin domain containing

    5/7 InterPro protein domains (see all 7):
     IPR000772 Ricin_B_lectin
     IPR016187 C-type_lectin_fold
     IPR013806 Kringle-like
     IPR018378 C-type_lectin_CS
     IPR000562 FN_type2_col-bd

    Graphical View of Domain Structure for InterPro Entry P22897

    ProtoNet protein and cluster: P22897

    2 Blocks protein domains:
    IPB000562 Type II fibronectin collagen-binding domain
    IPB000772 Ricin B lectin domain


    UniProtKB/Swiss-Prot: MRC1_HUMAN, P22897
    Similarity: Contains 8 C-type lectin domains
    Similarity: Contains 1 fibronectin type-II domain
    Similarity: Contains 1 ricin B-type lectin domain


    MRC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRC1_HUMAN, P22897
    Function: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated
    polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens

         Genatlas biochemistry entry for MRC1:
    mannose receptor C,type 1,expressed in macrophage,endothelial cells,binding oligosaccharides

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IDA--
    GO:0005537mannose binding TAS2373685
    GO:0030246carbohydrate binding ----
         
    MRC1 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mrc1):
     embryogenesis  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     reproductive system 

    MRC1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mrc1tm1Jub for MRC1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MRC1 
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MRC1 

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    SwitchGear 3'UTR luciferase reporter plasmidMRC1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRC1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MRC1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Cross-presentation of soluble exogenous antigens (endosomes)0.81
    Antigen processing-Cross presentation0.81
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3Antigen processing: Ubiquitination & Proteasome degradation
    Class I MHC mediated antigen processing & presentation0.83
    4Tuberculosis
    Tuberculosis
    5Phagosome
    Phagosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MRC1
        Phagocytosis of Microbes


    5        Reactome Pathways for MRC1
        Antigen processing-Cross presentation
    Cross-presentation of soluble exogenous antigens (endosomes)
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    2         Kegg Pathways  (Kegg details for MRC1):
        Phagosome
    Tuberculosis


    MRC1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MRC1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/6 Interacting proteins for MRC1 (P228973 ENSP000002397614) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHEK2O960173, ENSP000003720234I2D: score=1 STRING: ENSP00000372023
    BTKQ061873I2D: score=2 
    MAPK14Q165393I2D: score=2 
    PTPRCP085753I2D: score=1 
    SIGLEC1Q9BZZ23I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006898receptor-mediated endocytosis IDA--

    MRC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MRC1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRC1

    9 Novoseek inferred chemical compound relationships for MRC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 93.9 176 1903183 (4), 12566862 (4), 7868247 (4), 10683150 (3) (see all 99)
    mannan 86.8 5 7868255 (1), 11721968 (1), 7594549 (1), 19380112 (1)
    carbohydrates 47.5 3 11721968 (1), 8359512 (1)
    polysaccharide 42.7 6 18790466 (1), 17524049 (1)
    ricin 36.7 1 16441238 (1)
    galactose 18.1 2 19456233 (1)
    lysine 0 1 9020093 (1)
    nitric oxide 0 1 11204150 (1)
    superoxide 0 1 7806044 (1)

    Search CenterWatch for drugs/clinical trials and news about MRC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRC1 gene (2 alternative transcripts): 
    NM_001009567.1  NM_002438.3  

    Unigene Cluster for MRC1:

    Mannose receptor, C type 1
    Hs.75182  [show with all ESTs]
    Unigene Representative Sequence: J05550
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000239761(uc001ipm.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate MRC1 (see all 11):
    hsa-miR-130a* hsa-miR-522 hsa-miR-491-3p hsa-miR-23c hsa-miR-224* hsa-miR-511 hsa-miR-23b hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidMRC1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK128766.1 AK297044.1 AK308132.1 AK308167.1 BC016003.1 BC142642.1 BC146838.1 DQ663787.1 
    J05550.1 X55635.1 

    10 DOTS entries:

    DT.443385  DT.100752003  DT.101972721  DT.121225651  DT.91717457  DT.121225419  DT.91717423  DT.91948385 
    DT.95153494  DT.95153496 

    24/65 AceView cDNA sequences (see all 65):

    AA705679 BM992680 AA043388 BX114787 CR601686 AA758077 BM680134 T27627 
    AA358032 BM992752 BG542558 CA444230 AI337585 BG482859 AL545341 BQ029279 
    AA865708 AV717831 T16252 AI539173 AI494118 CA437381 H40026 BG537060 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRC1 expression in normal human tissues (normalized intensities)      MRC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAGAAGAA
    MRC1 Expression
    About this image


    MRC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hindlimb Dorsal Muscle
     
     Lung (Respiratory System)
             lung ; macrophages   
     
     Bone (Muscoskeletal System)
             Bone marrow-derived mesenchymal stem cells and monocytes (Ixmyelocel-T)

    See MRC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRC1

    SOURCE GeneReport for Unigene cluster: Hs.75182
        SABiosciences Expression via Pathway-Focused PCR Arrays including MRC1: 
              Antifungal Response in human mouse rat
              Allergy & Asthma in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MRC1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrc11 , 5 mannose receptor, C type 11, 5 82.22(n)1
    82.06(a)1
      2 (10.46 cM)5
    175331  NM_008625.21  NP_032651.21 
     142294145 
    chicken
    (Gallus gallus)
    Aves LOC4205161 macrophage mannose receptor 1-like 67.73(n)
    63.43(a)
      420516  XM_418618.2  XP_418618.2 
    lizard
    (Anolis carolinensis)
    Reptilia MRC1L16
    --
    (see all 7)
    --
    58(a)
    49(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    6(18062808-18115005)
    6(17965812-18008887)
    zebrafish
    (Danio rerio)
    Actinopterygii mrc1a1 mannose receptor, C type 1a 56(n)
    48.95(a)
      100286774  XM_002662968.1  XP_002663014.1 


    ENSEMBL Gene Tree for MRC1 (if available)
    TreeFam Gene Tree for MRC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRC1 gene
    LY752  PLA2R12  LY75-CD3022  MRC22  
    4 SIMAP similar genes for MRC1 using alignment to 2 protein entries:     MRC1_HUMAN (see all proteins):
    MRC1L1    MRC2    REG1B    REG1A

    MRC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: MRC1_HUMAN, P22897
    Polymorphism: Genetic variations in MRC1 may influence susceptibility or resistance to leprosy in some
    populations. Particularly, Gly-396 seems to be a risk factor for leprosy when associated with Ala-399 and Phe-407


    10/199 SNPs in MRC1 are shown (see all 199)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0652504
    ----see VAR_0652502 G S mis40--------
    VAR_0652524
    ----see VAR_0652522 L F mis40--------
    VAR_0652514
    ----see VAR_0652512 T A mis40--------
    VAR_0197004
    ----see VAR_0197002 T I mis40--------
    rs24776461,2
    C--17770283(-) GAAGAG/CGCTTC 1 -- int12Minor allele frequency- C:0.25NA 4
    rs24611441,2
    C,F--17770296(-) TCCCAT/AGTCAG 1 -- int14Minor allele frequency- A:0.43NA CSA 7
    rs561903851,2
    C--17770296(-) TCCCAA/TGTCAG 1 -- int10--------
    rs341799561,2
    C--17788565(+) AAAAA-/AGTAGA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs29858371,2
    C,O--17788791(+) CACCAG/AGCGAG 3 /H /Q mis12Minor allele frequency- A:0.25NA 4
    rs24776611,2
    C--17788886(-) ACTTGA/CGACTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for MRC1 (18098352 - 18200091 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MRC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2674193CNV Deletion23128226
    nsv508572CNV Loss20534489
    esv29303CNV Loss19812545
    nsv894913CNV Loss21882294
    esv25021CNV Loss19812545
    esv33746CNV Gain17666407


    Human Gene Mutation Database (HGMD): MRC1
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MRC1
    DNA2.0 Custom Variant and Variant Library Synthesis for MRC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 153618    OMIM disorders: --

    20/28 diseases for MRC1 (see all 28):    About MalaCards
    chickenpox    klebsiella    gaucher's disease    gastroparesis
    mumps    leprosy    rubella    lysosomal storage disease
    diarrhea    tuberculosis    monocytic leukemia    measles
    sinusitis    pertussis    sarcoidosis    skin disease
    vaginitis    inflammatory bowel disease    cystic fibrosis    pneumonia


    MRC1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for MRC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gaucher disease 43.4 1 17524049 (1)
    tuberculosis 34.1 5 16203868 (1), 7594549 (1), 16238626 (1), 19318518 (1) (see all 5)
    inflammation 13.2 4 18790466 (1), 8780401 (1)

    Genetic Association Database (GAD): MRC1
    Human Genome Epidemiology (HuGE) Navigator: MRC1 (5 documents)

    Export disorders for MRC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRC1 gene, integrated from 9 sources (see all 169):
    (articles sorted by number of sources associating them with MRC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Organization of the gene encoding the human macrophage mannose receptor (MRC1). (PubMed id 1294118)1, 2, 3, 9 Kim S.J.... Drickamer K. (1992)
    2. Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility. (PubMed id 20035344)1, 2, 4 Alter A....Schurr E. (2010)
    3. Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor. (PubMed id 1730714)1, 2, 9 Taylor M.E.... Drickamer K. (1992)
    4. Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. (PubMed id 2258707)1, 2, 9 Ezekowitz R.A.... Warner A. (1990)
    5. Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor. (PubMed id 10779515)1, 2, 9 Feinberg H....Weis W.I. (2000)
    6. Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C 4 genes are associated with multiple cardiovascular-related traits. (PubMed id 21943158)1, 4 Middelberg R.P....Whitfield J.B. (2011)
    7. Genome-wide association study of hematological and bi ochemical traits in a Japanese population. (PubMed id 20139978)1, 4 Kamatani Y....Kamatani N. (2010)
    8. Genetic variants in mannose receptor gene (MRC1) conf er susceptibility to increased risk of sarcoidosis. (PubMed id 21029423)1, 4 Hattori T....Nishimura M. (2010)
    9. Genetic variants in the mannose receptor gene (MRC1) are associated with asthma in two independent populations. (PubMed id 19902202)1, 4 Hattori T....Nishimura M. (2009)
    10. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4360 HGNC: 7228 AceView: MRC1.1 Ensembl:ENSG00000120586 euGenes: HUgn4360
    ECgene: MRC1 Kegg: 4360 H-InvDB: MRC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MRC1 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_00127

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRC1 gene:
    Search GeneIP for patents involving MRC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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