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Aliases for MRC1 Gene

Aliases for MRC1 Gene

  • Mannose Receptor, C Type 1 2 3
  • Macrophage Mannose Receptor 1-Like Protein 1 3 4
  • C-Type Lectin Domain Family 13 Member D 3 4
  • Mannose Receptor, C Type 1-Like 1 2 3
  • Human Mannose Receptor 3 4
  • CLEC13DL 3 4
  • CLEC13D 3 4
  • MRC1L1 3 4
  • HMR 3 4
  • MMR 3 4
  • C-Type Lectin Domain Family 13 Member D-Like 4
  • CD206 Antigen 4
  • BA541I19.1 3
  • CD206 3

External Ids for MRC1 Gene

Previous HGNC Symbols for MRC1 Gene

  • MRC1L1

Previous GeneCards Identifiers for MRC1 Gene

  • GC10P017833
  • GC10P018248
  • GC10P018102
  • GC10P018138
  • GC10P018098

Summaries for MRC1 Gene

Entrez Gene Summary for MRC1 Gene

  • The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]

GeneCards Summary for MRC1 Gene

MRC1 (Mannose Receptor, C Type 1) is a Protein Coding gene. Diseases associated with MRC1 include primary bacterial infectious disease and primary systemic mycosis. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include receptor activity and mannose binding.

UniProtKB/Swiss-Prot for MRC1 Gene

  • Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains

  • (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. Acts as a receptor for Dengue virus envelope protein E (PubMed:18266465). Interacts with hepatitis B virus envelope protein (PubMed:19683778).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRC1 Gene

Genomics for MRC1 Gene

Genomic Location for MRC1 Gene

Chromosome:
10
Start:
17,809,343 bp from pter
End:
17,911,170 bp from pter
Size:
101,828 bases
Orientation:
Plus strand

Genomic View for MRC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRC1 Gene

Proteins for MRC1 Gene

  • Protein details for MRC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22897-MRC1_HUMAN
    Recommended name:
    Macrophage mannose receptor 1
    Protein Accession:
    P22897
    Secondary Accessions:
    • A5PKW3
    • Q5VSJ2
    • Q5VSK2

    Protein attributes for MRC1 Gene

    Size:
    1456 amino acids
    Molecular mass:
    166012 Da
    Quaternary structure:
    • (Microbial infection) Interacts with Dengue virus (PubMed:18266465). (Microbial infection) May act as a receptor for hepatitis B virus, enabling uptake of the virus in hepatic dendritic cells (PubMed:19683778).
    Miscellaneous:
    • CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates
    SequenceCaution:
    • Sequence=CAH70733.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH70872.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH71176.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15339.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRC1 Gene

    Alternative splice isoforms for MRC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRC1 Gene

Proteomics data for MRC1 Gene at MOPED

Post-translational modifications for MRC1 Gene

  • Glycosylation at Asn 104, Asn 344, Asn 529, Asn 926, Asn 930, Asn 1160, Asn 1205, and Asn 1311
  • Modification sites at PhosphoSitePlus

Other Protein References for MRC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MRC1 (MRC1)

No data available for DME Specific Peptides for MRC1 Gene

Domains & Families for MRC1 Gene

Gene Families for MRC1 Gene

Suggested Antigen Peptide Sequences for MRC1 Gene

Graphical View of Domain Structure for InterPro Entry

P22897

UniProtKB/Swiss-Prot:

MRC1_HUMAN :
  • Contains 8 C-type lectin domains.
Domain:
  • Contains 8 C-type lectin domains.
  • Contains 1 fibronectin type-II domain.
  • Contains 1 ricin B-type lectin domain.
genes like me logo Genes that share domains with MRC1: view

Function for MRC1 Gene

Molecular function for MRC1 Gene

GENATLAS Biochemistry:
mannose receptor C,type 1,expressed in macrophage,endothelial cells,binding oligosaccharides
UniProtKB/Swiss-Prot Function:
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. Acts as a receptor for Dengue virus envelope protein E (PubMed:18266465). Interacts with hepatitis B virus envelope protein (PubMed:19683778).

Gene Ontology (GO) - Molecular Function for MRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004872 receptor activity IDA 20035344
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005515 protein binding IPI 11222859
GO:0005537 mannose binding IEA --
genes like me logo Genes that share ontologies with MRC1: view
genes like me logo Genes that share phenotypes with MRC1: view

Animal Models for MRC1 Gene

MGI Knock Outs for MRC1:

Animal Model Products

miRNA for MRC1 Gene

miRTarBase miRNAs that target MRC1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MRC1 Gene

Localization for MRC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRC1 Gene

Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRC1 Gene COMPARTMENTS Subcellular localization image for MRC1 gene
Compartment Confidence
endosome 5
plasma membrane 5
extracellular 2
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 20035344
GO:0005887 integral component of plasma membrane TAS 1294118
GO:0009986 cell surface IEA --
GO:0010008 endosome membrane IDA 20035344
genes like me logo Genes that share ontologies with MRC1: view

Pathways & Interactions for MRC1 Gene

genes like me logo Genes that share pathways with MRC1: view

PCR Array Products

Interacting Proteins for MRC1 Gene

Selected Interacting proteins: P22897-MRC1_HUMAN for MRC1 Gene via I2D

Gene Ontology (GO) - Biological Process for MRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IDA 20035344
GO:0007165 signal transduction IEA --
GO:0046718 viral entry into host cell IEA --
GO:0071222 cellular response to lipopolysaccharide IEA --
GO:0071346 cellular response to interferon-gamma IEA --
genes like me logo Genes that share ontologies with MRC1: view

No data available for SIGNOR curated interactions for MRC1 Gene

Drugs & Compounds for MRC1 Gene

(2) Drugs for MRC1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nitric Oxide Approved Pharma 540
lysine Nutra 70

(7) Additional Compounds for MRC1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Carbohydrates
Galactose
mannan
  • Mannans
  • Mannoglycan
9036-88-8
mannose
polysaccharide
genes like me logo Genes that share compounds with MRC1: view

Transcripts for MRC1 Gene

mRNA/cDNA for MRC1 Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(65) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRC1 Gene

Mannose receptor, C type 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRC1 Gene

No ASD Table

Relevant External Links for MRC1 Gene

GeneLoc Exon Structure for
MRC1
ECgene alternative splicing isoforms for
MRC1

Expression for MRC1 Gene

mRNA expression in normal human tissues for MRC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MRC1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x6.9) and Lung (x6.5).

Protein differential expression in normal tissues from HIPED for MRC1 Gene

This gene is overexpressed in Milk (20.0) and Serum (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MRC1 Gene



SOURCE GeneReport for Unigene cluster for MRC1 Gene Hs.75182

genes like me logo Genes that share expression patterns with MRC1: view

Protein tissue co-expression partners for MRC1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MRC1 Gene

Orthologs for MRC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRC1 35
  • 87.18 (n)
  • 87.36 (a)
dog
(Canis familiaris)
Mammalia MRC1 35
  • 87.89 (n)
  • 88.9 (a)
mouse
(Mus musculus)
Mammalia Mrc1 35
  • 82.25 (n)
  • 82.06 (a)
Mrc1 16
chimpanzee
(Pan troglodytes)
Mammalia MRC1 35
  • 99.04 (n)
  • 99.45 (a)
rat
(Rattus norvegicus)
Mammalia Mrc1 35
  • 81.7 (n)
  • 83.44 (a)
chicken
(Gallus gallus)
Aves LOC420516 35
  • 67.59 (n)
  • 63.04 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrc1 35
  • 62.16 (n)
  • 55.44 (a)
zebrafish
(Danio rerio)
Actinopterygii mrc1a 35
  • 57.18 (n)
  • 51.52 (a)
Species with no ortholog for MRC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRC1 Gene

ENSEMBL:
Gene Tree for MRC1 (if available)
TreeFam:
Gene Tree for MRC1 (if available)

Paralogs for MRC1 Gene

(4) SIMAP similar genes for MRC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MRC1: view

No data available for Paralogs for MRC1 Gene

Variants for MRC1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MRC1 Gene

P22897-MRC1_HUMAN
Genetic variations in MRC1 may influence susceptibility or resistance to leprosy in some populations. Particularly, Gly-396 seems to be a risk factor for leprosy when associated with Ala-399 and Phe-407

Sequence variations from dbSNP and Humsavar for MRC1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs941 -- 17,910,881(+) CAAAT(A/T)TCCTC utr-variant-3-prime
rs482272 -- 17,847,790(+) AATAT(G/T)TTTAA intron-variant
rs499819 -- 17,908,543(+) CTGGT(A/G)CAATG intron-variant
rs506524 -- 17,840,863(-) TCTTC(A/G)GGGCG intron-variant
rs514707 -- 17,879,917(+) ATCAG(A/G)CAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRC1 Gene

Variant ID Type Subtype PubMed ID
esv2674193 CNV Deletion 23128226
esv29303 CNV Loss 19812545
esv33746 CNV Gain 17666407
nsv508572 CNV Loss 20534489
esv25021 CNV Loss 19812545
nsv894913 CNV Loss 21882294

Variation tolerance for MRC1 Gene

Gene Damage Index Score: 11.81; 93.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRC1 Gene

HapMap Linkage Disequilibrium report
MRC1
Human Gene Mutation Database (HGMD)
MRC1

Disorders for MRC1 Gene

MalaCards: The human disease database

(25) MalaCards diseases for MRC1 Gene - From: DISEASES, NovoSeek, and GeneCards

Relevant External Links for MRC1

Genetic Association Database (GAD)
MRC1
Human Genome Epidemiology (HuGE) Navigator
MRC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRC1
genes like me logo Genes that share disorders with MRC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRC1 Gene

Publications for MRC1 Gene

  1. Organization of the gene encoding the human macrophage mannose receptor (MRC1). (PMID: 1294118) Kim S.J. … Drickamer K. (Genomics 1992) 2 23 67
  2. Comparative characterization of cultures of primary human macrophages or dendritic cells relevant to biomaterial studies. (PMID: 19274715) Shankar S.P. … Babensee J.E. (J Biomed Mater Res A 2010) 23 67
  3. A novel pseudopodial component of the dendritic cell anti-fungal response: the fungipod. (PMID: 20169183) Neumann A.K. … Jacobson K. (PLoS Pathog. 2010) 23 67
  4. Oligomerization of the macrophage mannose receptor enhances gp120-mediated binding of HIV-1. (PMID: 19224860) Lai J. … Cunningham A.L. (J. Biol. Chem. 2009) 23 67
  5. The macrophage mannose receptor induces IL-17 in response to Candida albicans. (PMID: 19380112) van de Veerdonk F.L. … Netea M.G. (Cell Host Microbe 2009) 23 67

Products for MRC1 Gene

Sources for MRC1 Gene

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