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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MRC1 Gene

protein-coding GIFtS: 60
GCID: GC10P018098

mannose receptor, C type 1

(Previous names: mannose receptor, C type 1-like 1 )
(Previous symbol: MRC1L1)

Explore 30 diseases affiliated with
MRC1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mannose Receptor, C Type 1¹ ²		Mannose Receptor, C Type 1-Like 1¹ ²
CLEC13D¹ ² ³		Macrophage Mannose Receptor 1-Like Protein 1² ³
CLEC13DL¹ ² ³		C-Type Lectin Domain Family 13 Member D² ³
MRC1L1¹ ² ³		Macrophage Mannose Receptor 1²
MMR² ³ ⁵		C-Type Lectin Domain Family 13 Member D-Like³
CD206¹ ²		CD206 Antigen³
BA541I19.1¹

External Ids:	HGNC: 7228¹	Entrez Gene: 4360²	Ensembl: ENSG00000120586⁷	OMIM: 153618⁵	UniProtKB: P22897³

Export aliases for MRC1 gene to outside databases

Previous GC identifers: GC10P017833 GC10P018248 GC10P018102 GC10P018138

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRC1:

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological

processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein

encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The

protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and

fungi so that they can be neutralized by phagocytic engulfment.(provided by RefSeq, Apr 2011)

UniProtKB/Swiss-Prot: MRC1_HUMAN, P22897

Function: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide

chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008705.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MRC1 gene promoter:
MEF-2 Olf-1 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 C/EBPalpha AREB6 MEF-2A HSF2 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MRC1 promoter sequence

Search SABiosciences Chromatin IP Primers for MRC1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.33 Ensembl cytogenetic band: 10p12.33 HGNC cytogenetic band: 10p13

MRC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRC1 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P018098: view genomic region (about GC identifiers)

Start:	18,098,352 bp from pter	End:	18,200,091 bp from pter
Size:	101,740 bases	Orientation:	plus strand

1 alternative location:

Chr10+,PATCHES 17,974,827-18,076,626

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MRC1_HUMAN, P22897 (See protein sequence)

Recommended Name: Macrophage mannose receptor 1 precursor

Size: 1456 amino acids; 166012 Da

Subcellular location: Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I

membrane protein

Miscellaneous: CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and

has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity

binding and endocytosis of multivalent glycoconjugates

Sequence caution: Sequence=CAH70733.1; Type=Erroneous gene model prediction; Sequence=CAH70872.1; Type=Erroneous gene

model prediction; Sequence=CAH71176.1; Type=Erroneous gene model prediction; Sequence=CAI15339.1; Type=Erroneous gene

model prediction;

2 PDB 3D structures from and Proteopedia for MRC1:

1EGG (3D)

1EGI (3D)

Secondary accessions: A5PKW3 Q5VSJ2 Q5VSK2

Alternative splicing: 2 isoforms: P22897-1 P22897-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MRC1: NX_P22897

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P22897

MRC1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002429.1

ENSEMBL proteins:

ENSP00000239761

Reactome Protein details: P22897
Human Recombinant Protein Products for MRC1:

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	Novus Biologicals MRC1 Protein
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	Uscn Proteins for MRC1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IDA	--
GO:0005887	integral to plasma membrane	TAS	1294118
GO:0010008	endosome membrane	IDA	--

MRC1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for MRC1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MRC1 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR000772 Ricin_B_lectin

IPR016187 C-type_lectin_fold

IPR013806 Kringle-like

IPR018378 C-type_lectin_CS

IPR000562 FN_type2_col-bd

Graphical View of Domain Structure for InterPro Entry P22897

ProtoNet protein and cluster: P22897

2 Blocks protein families:

IPB000562 Type II fibronectin collagen-binding domain

IPB000772 Ricin B lectin domain

UniProtKB/Swiss-Prot: MRC1_HUMAN, P22897

Similarity: Contains 8 C-type lectin domains

Similarity: Contains 1 fibronectin type-II domain

Similarity: Contains 1 ricin B-type lectin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MRC1_HUMAN, P22897

Function: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide

chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens

Genatlas biochemistry entry for MRC1:

mannose receptor C,type 1,expressed in macrophage,endothelial cells,binding oligosaccharides

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IDA	--
GO:0005537	mannose binding	TAS	2373685

MRC1 for ontologies About GeneDecksing

Phenotypes:
5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mrc1):

embryogenesis

homeostasis/metabolism

immune system

mortality/aging

reproductive system

MRC1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Mrc1^tm1Jub for MRC1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MRC1

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		hsa-miR-130a* hsa-miR-522 hsa-miR-491-3p hsa-miR-23c hsa-miR-224* hsa-miR-511 hsa-miR-23b hsa-miR-205*

		SwitchGear 3'UTR luciferase reporter plasmid: MRC1 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRC1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Ubiquitinated Orc1 is degraded by the proteasome

Cross-presentation of soluble exogenous antigens (endosomes)

0.81

Antigen processing-Cross presentation

0.60

Phagocytosis of Microbes

Phagocytosis of Microbes

1.00

Tuberculosis

Tuberculosis

1.00

Phagosome

Phagosome

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MRC1

Phagocytosis of Microbes

5 Reactome Pathways for MRC1

	Antigen processing-Cross presentation
	Cross-presentation of soluble exogenous antigens (endosomes)
	Adaptive Immune System
	Class I MHC mediated antigen processing & presentation
	Immune System

2 Kegg Pathways (Kegg details for MRC1):

	Phagosome
	Tuberculosis

MRC1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MRC1

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

5/6 Interacting proteins for MRC1 (P22897³ ENSP00000239761⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CHEK2	O96017³, ENSP00000372023⁴	I2D: score=1 STRING: ENSP00000372023
BTK	Q06187³	I2D: score=2
MAPK14	Q16539³	I2D: score=2
PTPRC	P08575³	I2D: score=1
SIGLEC1	Q9BZZ2³	I2D: score=1

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006898	receptor-mediated endocytosis	IDA	--

MRC1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MRC1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MRC1
9 Novoseek chemical compound relationships for MRC1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mannose	93.9	176	1903183 (4), 12566862 (4), 7868247 (4), 10683150 (3) (see all 99)
mannan	86.8	5	7868255 (1), 11721968 (1), 7594549 (1), 19380112 (1)
carbohydrates	47.5	3	11721968 (1), 8359512 (1)
polysaccharide	42.7	6	18790466 (1), 17524049 (1)
ricin	36.7	1	16441238 (1)
galactose	18.1	2	19456233 (1)
lysine	0	1	9020093 (1)
nitric oxide	0	1	11204150 (1)
superoxide	0	1	7806044 (1)

Search CenterWatch for drugs/clinical trials and news about MRC1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MRC1 gene (2 alternative transcripts):

NM_001009567.1 NM_002438.2

Unigene Cluster for MRC1:

Mannose receptor, C type 1

Hs.75182 [show with all ESTs]

Unigene Representative Sequence: J05550

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000239761(uc001ipm.3)

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		hsa-miR-130a* hsa-miR-522 hsa-miR-491-3p hsa-miR-23c hsa-miR-224* hsa-miR-511 hsa-miR-23b hsa-miR-205*

		SwitchGear 3'UTR luciferase reporter plasmid: MRC1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRC1

Additional cDNA sequence:

AK128766.1 AK297044.1 AK308132.1 AK308167.1 BC016003.1 BC142642.1 BC146838.1 DQ663787.1

J05550.1 X55635.1

10 DOTS entries:

DT.443385 DT.100752003 DT.101972721 DT.121225651 DT.91717457 DT.121225419 DT.91717423 DT.91948385

DT.95153494 DT.95153496

24/65 AceView cDNA sequences (see all 65):

BM680134 BM992680 AA758077 T27627 CA444230 AA358032 CR601686 AA705679

AA043388 BG542558 BM992752 BX114787 AI337585 BI759549 BX645193 AI458333

AV716602 R11028 AU139363 AL545341 AV717831 BC016003 H40026 BM724899

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MRC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCAGAAGAA

About this image

MRC1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/23 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 23)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Forelimb Dorsal Muscles

Mononuclear Myocytes

Skeletal Muscle

Limb

Forelimb Ventral Muscles

Mononuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Dorsal Muscle

Mononuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Ventral Muscle

Mononuclear Myocytes

Skeletal Muscle

Thoracic Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Hypaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Primary Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Primary Hypaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Lumbar Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Bone marrow-derived mesenchymal stem cells and myocytes (Ixmyelocel-T) (Adult Stem / Progenitor Cell)

Bone

See MRC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRC1

SOURCE GeneReport for Unigene cluster: Hs.75182

SABiosciences Expression via Pathway-Focused PCR Arrays including MRC1:

Antifungal Response in human mouse rat

Allergy & Asthma in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRC1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MRC1 gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mrc1^{1 , 5}	mannose receptor, C type 1^{1, 5}	82.22(n)¹ 82.06(a)¹		2 (10.46 cM)⁵ 17533¹ NM_008625.2¹ NP_032651.2¹ 14229414⁵
chicken (Gallus gallus)	Aves	LOC420516¹	macrophage mannose receptor 1-like	67.73(n) 63.43(a)		420516 XM_418618.2 XP_418618.2
lizard (Anolis carolinensis)	Reptilia	-- --	--	58(a) 48(a)	possible ortholog possible ortholog	6(18062808-18114715) 6(17973694-18006877)
zebrafish (Danio rerio)	Actinopterygii	mrc1a¹	mannose receptor, C type 1a	56(n) 48.95(a)		100286774 XM_002662968.1 XP_002663014.1
worm (Caenorhabditis elegans)	Secernentea	clec-178⁶	C-type LECtin family member (clec-178)	25(a)	possible ortholog	IV(5653976-5654993)

ENSEMBL Gene Tree for MRC1 (if available)
TreeFam Gene Tree for MRC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MRC1 gene

LY75² PLA2R1² ENSG00000183748² LY75-CD302² MRC2²

5 SIMAP similar genes for MRC1 using alignment to 2 protein entries: MRC1_HUMAN (see all proteins):

MRC1L1 MRC2 REG1B REG1A PLA2R1

MRC1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: MRC1_HUMAN, P22897

Polymorphism: Genetic variations in MRC1 may influence susceptibility or resistance to leprosy in some populations.

Particularly, Gly-396 seems to be a risk factor for leprosy when associated with Ala-399 and Phe-407

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2461142^1,2	C,F	--	17772034(-)	`AAAATG/TATGCC`	1	--	int¹		2	NA	4
rs2947600^1,2	O	--	17772546(+)	`TTGCCC/TTTGAG`	1	--	int¹		1	NA	2
rs2477645^1,2	C,O	--	17772789(-)	`ATCTCT/ATTTGT`	1	--	int¹		2	NA WA	4
rs2436680^1,2	C,O	--	17773359(-)	`GCGGAG/AGCATC`	1	--	int¹		2	NA CSA	3
rs2436679^1,2	C	--	17773417(-)	`GAGCAT/CAAATA`	1	--	int¹		2	NA	4
rs2477644^1,2	C,F	--	17773909(-)	`TTTCCT/GTTTCT`	1	--	int¹		3	NA	6
rs2461141^1,2	C	--	17774948(-)	`atcctG/Cccact`	1	--	int¹		1	NA	2
rs2461140^1,2	C	--	17775118(-)	`AAGAAG/CAAAAA`	1	--	int¹ trp³		1	NA	2
rs2477643^1,2	C,O	--	17775599(-)	`GAAGGC/TGTTCA`	1	--	int¹		3	NA WA	6
rs2477642^1,2	C,F	--	17776133(-)	`TACCTA/C/GTCCCA`	1	--	int¹		5	EA NA CSA	215

HapMap Linkage Disequilibrium report for MRC1 (18098352 - 18200091 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for MRC1
5 CNVs: 65603 6855 65602 85124 85126
1 Indel: 85125
Human Gene Mutation Database (HGMD): MRC1

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MRC1 for disorders           About GeneDecksing

OMIM gene information: 153618    OMIM disorders: --

20/30 diseases for MRC1 (see all 30):    About MalaCards

lysosomal storage disease gaucher's disease klebsiella inflammatory bowel disease

chickenpox leprosy gastroparesis monocytic leukemia

mumps cystic fibrosis rubella skin disease

hepatitis b diarrhea measles sarcoidosis

sinusitis fibrosis pneumonia pertussis

4 diseases from the University of Copenhagen DISEASES database for MRC1:

Mumps Rubella Measles Chickenpox

3 Novoseek disease relationships for MRC1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gaucher disease	43.4	1	17524049 (1)
tuberculosis	34.1	5	16203868 (1), 7594549 (1), 16238626 (1), 19318518 (1) (see all 5)
inflammation	13.2	4	18790466 (1), 8780401 (1)

Genetic Association Database (GAD): MRC1
Human Genome Epidemiology (HuGE) Navigator: MRC1 (5 documents)

Export disorders for MRC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MRC1 gene, integrated from 9 sources (see all 164):
(articles sorted by number of sources associating them with MRC1)

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world of online information

Organization of the gene encoding the human macrophage mannose receptor (MRC1). (PubMed id 1294118)^{1, 2, 3, 9} Kim S.J.... Drickamer K. (1992)
Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor. (PubMed id 1730714)^{1, 2, 9} Taylor M.E.... Drickamer K. (1992)
Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. (PubMed id 2258707)^{1, 2, 9} Ezekowitz R.A.... Warner A. (1990)
Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor. (PubMed id 10779515)^{1, 2, 9} Feinberg H....Weis W.I. (2000)
Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility. (PubMed id 20035344)^{1, 2} Alter A....Schurr E. (2010)
MSH2 c.1452-1455delAATG is a founder mutation and an important cause of hereditary nonpolyposis colorectal cancer in the southern Chinese population. (PubMed id 15042510)^{1, 4} Chan T.L....Yuen S.T. (2004)
Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains. (PubMed id 2373685)^{1, 2} Taylor M.E.... Drickamer K. (1990)
The human macrophage mannose receptor is not a professional phagocytic receptor. (PubMed id 15767290)^{1, 9} Le Cabec V....Maridonneau-Parini I. (2005)
Oligomerization of the macrophage mannose receptor enhances gp120-mediated binding of HIV-1. (PubMed id 19224860)^{1, 9} Lai J....Cunningham A.L. (2009)
The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis. (PubMed id 16203868)^{1, 9} Kang P.B....Schlesinger L.S. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4360	HGNC: 7228	AceView: MRC1.1	Ensembl:ENSG00000120586	euGenes: HUgn4360
ECgene: MRC1	Kegg: 4360	H-InvDB: MRC1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MRC1	Pharmacogenomics, SNPs, Pathways
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_00127

Intellectual Property for MRC1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MRC1 gene:
Search GeneIP for patents involving MRC1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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mannose receptor, C type 1

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mannose receptor, C type 1

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