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MRAS Gene

protein-coding   GIFtS: 62
GCID: GC03P138066

Muscle RAS Oncogene Homolog

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Muscle RAS Oncogene Homolog1 2     R-RAS32
RRAS32 3 5     Muscle And Microspikes RAS2
Ras-Related Protein R-Ras32 3     Ras-Related Protein M-Ras2
M-RAs2     

External Ids:    HGNC: 72271   Entrez Gene: 228082   Ensembl: ENSG000001581867   OMIM: 6084355   UniProtKB: O148073   

Export aliases for MRAS gene to outside databases

Previous GC identifers: GC03P135051 GC03P138859 GC03P139348 GC03P139388 GC03P139387 GC03P139549 GC03P135441


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRAS Gene:
This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as
signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras
signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor
necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding
multiple isoforms have been observed for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for MRAS Gene:
MRAS (muscle RAS oncogene homolog) is a protein-coding gene. GO annotations related to this gene include GTP binding and GTP-dependent protein binding. An important paralog of this gene is REM1.

UniProtKB/Swiss-Prot: RASM_HUMAN, O14807
Function: May serve as an important signal transducer for a novel upstream stimuli in controlling cell
proliferation. Weakly activates the MAP kinase pathway

Gene Wiki entry for MRAS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRAS gene promoter:
         HOXA9B   HOXA9   HEN1   CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): MRAS promoter sequence
   Search Chromatin IP Primers for MRAS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRAS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3   Ensembl cytogenetic band:  3q22.3   HGNC cytogenetic band: 3q22.3

MRAS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRAS gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P138066:  view genomic region     (about GC identifiers)

Start:
138,066,539 bp from pter      End:
138,124,377 bp from pter
Size:
57,839 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RASM_HUMAN, O14807 (See protein sequence)
Recommended Name: Ras-related protein M-Ras precursor  
Size: 208 amino acids; 23846 Da
Subunit: Interacts with RGL3. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Forms a
multiprotein complex with SHOC2, Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC)
Secondary accessions: B4DIK0 Q86WX8
Alternative splicing: 2 isoforms:  O14807-1   O14807-2   

Explore the universe of human proteins at neXtProt for MRAS: NX_O14807

Explore proteomics data for MRAS at MOPED


See MRAS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (6 alternative transcripts): 
NP_001078518.1  NP_001239019.1  NP_001239020.1  NP_001239021.1  NP_001239022.1  NP_036351.3  

ENSEMBL proteins: 
 ENSP00000289104   ENSP00000389682   ENSP00000417685   ENSP00000417092   ENSP00000419582  
 ENSP00000418356  

MRAS Human Recombinant Protein Products:

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Novus Biologicals MRAS Proteins
Novus Biologicals MRAS Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for MRAS
Cloud-Clone Corp. Proteins for MRAS

 
Search eBioscience for Proteins for MRAS 

MRAS Antibody Products:

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Search for Antibodies for MRAS at Abcam
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ThermoFisher Antibodies for MRAS
LSBio Antibodies in human, mouse, rat for MRAS

MRAS Assay Products:

EMD Millipore Kits and Assays for the Analysis of MRAS
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Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for MRAS
Cloud-Clone Corp. CLIAs for MRAS
Search eBioscience for ELISAs for MRAS 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR005225 Small_GTP-bd_dom
 IPR001806 Small_GTPase
 IPR027417 P-loop_NTPase
 IPR020849 Small_GTPase_Ras

Graphical View of Domain Structure for InterPro Entry O14807

ProtoNet protein and cluster: O14807

2 Blocks protein domains:
IPB001806 Transforming protein P21 RAS signature
IPB003577 Ras small GTPase


UniProtKB/Swiss-Prot: RASM_HUMAN, O14807
Similarity: Belongs to the small GTPase superfamily. Ras family


Find genes that share domains with MRAS           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RASM_HUMAN, O14807
Function: May serve as an important signal transducer for a novel upstream stimuli in controlling cell
proliferation. Weakly activates the MAP kinase pathway
Induction: By IL9/interleukin-9, but not by IL2/interleukin-2 or IL4/interleukin-4

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003924GTPase activity TAS10446149
GO:0005525GTP binding IEA--
GO:0030742GTP-dependent protein binding IPI10934204
     
Find genes that share ontologies with MRAS           About GenesLikeMe


Phenotypes:
     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mras):
 hematopoietic system  immune system  normal 

Find genes that share phenotypes with MRAS           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRAS
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MRAS

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRAS
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MRAS

miRNA
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miRTarBase miRNAs that target MRAS:
hsa-mir-652-3p (MIRT039529)

Block miRNA regulation of human, mouse, rat MRAS using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate MRAS (see all 45):
hsa-miR-15a hsa-miR-424 hsa-miR-34b hsa-miR-15b hsa-miR-3163 hsa-miR-3065-3p hsa-miR-1 hsa-miR-224*
SwitchGear 3'UTR luciferase reporter plasmidMRAS 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for MRAS
Predesigned siRNA for gene silencing in human, mouse, rat MRAS

Gene Editing
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OriGene ORF clones in mouse, rat for MRAS
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GenScript: all cDNA clones in your preferred vector (see all 2): MRAS (NM_012219)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRAS
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRAS

Cell Line
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GenScript Custom overexpressing Cell Line Services for MRAS
Browse ESI BIO Cell Lines and PureStem Progenitors for MRAS 
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRAS


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RASM_HUMAN, O14807: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
cytosol3
nucleus2
endosome1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005886plasma membrane IEA--
GO:0016020membrane ----

Find genes that share ontologies with MRAS           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MRAS About   (see all 54)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1Regulation of actin cytoskeleton
Regulation of actin cytoskeleton0.57
Regulation of Actin Cytoskeleton0.57
2MAPK signaling pathway
MAPK signaling pathway0.50
MAPK signaling pathway0.50
3ErbB4 Pathway
ErbB4 Pathway0.59
UVC-Induced MAPK Signaling0.44
ErbB Family Pathway0.59
TREM1 Pathway0.43
Prolactin Signaling0.54
FGF Pathway0.37
Thrombopoietin Pathway0.51
HMGB1 Pathway0.36
4Apoptotic Pathways in Synovial Fibroblasts
PPAR Pathway0.66
ERK5 Signaling0.61
Rac1 Pathway0.65
eIF2 Pathway0.60
Glioma Invasiveness0.64
Rap1 Pathway0.57
5GPCR Pathway
Ras Pathway0.73
Breast Cancer Regulation by Stathmin10.58
Paxillin Interactions0.73
Estrogen Pathway0.55
GPCR Pathway0.62
P2Y Receptor Signaling0.38


Find genes that share SuperPaths with MRAS           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MRAS (see all 108)
    Fc-GammaR Pathway
Molecular Mechanisms of Cancer
eIF2 Pathway
Intracellular Calcium Signaling
CDK5 Pathway

Selected GeneGo (Thomson Reuters) Pathways for MRAS (see all 6)
    G-protein signaling M-RAS regulation pathway
G-protein signaling Cross-talk between Ras-family GTPases
G-protein signaling Rap1A regulation pathway
G-protein signaling Rap2B regulation pathway
Development G-Proteins mediated regulation MARK-ERK signaling

3 BioSystems Pathways for MRAS
    MAPK signaling pathway
Regulation of Actin Cytoskeleton
IL-3 Signaling Pathway

3 PharmGKB Pathways for MRAS
    Bisphosphonate Pathway, Pharmacodynamics
EGFR Inhibitor Pathway, Pharmacodynamics
Vemurafenib Pathway, Pharmacodynamics

Selected Kegg Pathways  (Kegg details for MRAS) (see all 7):
    MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Tight junction
Regulation of actin cytoskeleton

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRAS
Interactions:

    GeneGlobe Interaction Network for MRAS

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MRAS (O148072, 3 ENSP000002891044) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
InteractantInteraction Details
GeneCardExternal ID(s)
PLXNB1O431572, 3, ENSP000002964404MINT-7228875 I2D: score=1 STRING: ENSP00000296440
MLLT4P551962, 3, ENSP000003836234MINT-15307 MINT-15308 I2D: score=2 STRING: ENSP00000383623
RASSF5Q8WWW03, ENSP000003474434I2D: score=2 STRING: ENSP00000347443
RAF1P040493, ENSP000002518494I2D: score=2 STRING: ENSP00000251849
RALGDSQ129673, ENSP000003611204I2D: score=2 STRING: ENSP00000361120
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Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006184GTP catabolic process ----
GO:0006886intracellular protein transport ----
GO:0006913nucleocytoplasmic transport ----
GO:0007165signal transduction ----
GO:0007264small GTPase mediated signal transduction ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MRAS (RASM)

1 Novoseek inferred chemical compound relationship for MRAS gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
gtp 34.6 1 17497936 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MRAS gene (6 alternative transcripts): 
NM_001085049.2  NM_001252090.1  NM_001252091.1  NM_001252092.1  NM_001252093.1  NM_012219.4  

Unigene Cluster for MRAS:

Muscle RAS oncogene homolog
Hs.527021  [show with all ESTs]
Unigene Representative Sequence: NM_012219
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000289104(uc003esh.4 uc011bmi.2 uc003esi.4 uc021xep.1 uc011bmj.2 uc021xeq.1)
ENST00000423968 ENST00000494949 ENST00000475711 ENST00000464896 ENST00000477784
ENST00000461114 ENST00000474559 ENST00000478647
miRNA
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Block miRNA regulation of human, mouse, rat MRAS using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate MRAS (see all 45):
hsa-miR-15a hsa-miR-424 hsa-miR-34b hsa-miR-15b hsa-miR-3163 hsa-miR-3065-3p hsa-miR-1 hsa-miR-224*
SwitchGear 3'UTR luciferase reporter plasmidMRAS 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for MRAS
Predesigned siRNA for gene silencing in human, mouse, rat MRAS
Clone
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OriGene clones in human, mouse for MRAS (see all 13)
OriGene ORF clones in mouse, rat for MRAS
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): MRAS (NM_012219)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRAS
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRAS
Primer
Products:
    
OriGene qPCR primer pairs and template standards for MRAS
OriGene qSTAR qPCR primer pairs in human, mouse for MRAS
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRAS
  QuantiTect SYBR Green Assays in human, mouse, rat MRAS
  QuantiFast Probe-based Assays in human, mouse, rat MRAS

Additional mRNA sequence: 

AF022080.1 AF493918.1 AK056337.1 AK091633.1 AK123833.1 AK124954.1 AK295640.1 AK316071.1 
BC017733.1 BC035939.1 BC047101.1 BC047690.1 BT020057.1 CR542067.1 

14 DOTS entries:

DT.455948  DT.97792056  DT.97844833  DT.75110496  DT.95375945  DT.120895221  DT.95152429  DT.120895208 
DT.120895223  DT.95375942  DT.97844831  DT.100823682  DT.120895214  DT.97790799 

Selected AceView cDNA sequences (see all 216):

AF493918 AI373696 AA902417 AA450261 AK123833 BX505620 CR542067 AI304356 
AK124954 BM709786 AI143993 CB134363 BF437869 AA953982 BX503289 AI138631 
CD723830 AI280242 BQ881794 CR590782 AI394207 BU509509 AW008420 BX090498 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for MRAS (see all 7)    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1:        -     -     -     -     -     -     -     -                                             
SP2:                    -     -     -     -     -     -                                             
SP3:                                            -     -                                             
SP4:                    -     -     -     -     -     -     -                                       
SP5:                                -     -     -     -                                             


ECgene alternative splicing isoforms for MRAS

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MRAS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCGGGTTTAC
MRAS Expression
About this image


MRAS expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 7) fully expand
 
 Testis (Reproductive System)
         Pre-Sertoli Cells Testis Cord
 
 Epiblast (Early Embryonic Tissues)
         Epiblast-like cells
 
 Blood (Cardiovascular System)
         Conventional Dendritic Cells I Spleen
 
 Brain (Nervous System)
         Cerebral Cortex
 
 Spleen (Hematopoietic System)
         Conventional Dendritic Cells I Spleen
MRAS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MRAS Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.527021

UniProtKB/Swiss-Prot: RASM_HUMAN, O14807
Tissue specificity: Expression highly restricted to the brain and heart

    Custom PCR Arrays for MRAS
Primer
Products:
OriGene qPCR primer pairs and template standards for MRAS
OriGene qSTAR qPCR primer pairs in human, mouse for MRAS
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRAS
QuantiTect SYBR Green Assays in human, mouse, rat MRAS
QuantiFast Probe-based Assays in human, mouse, rat MRAS
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRAS

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for MRAS gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mras1 , 5 muscle and microspikes RAS1, 5 89.42(n)1
96.63(a)1
  9 (51.63 cM)5
175321  NM_008624.31  NP_032650.11 
 993854225 
chicken
(Gallus gallus)
Aves MRAS1 muscle RAS oncogene homolog 83.97(n)
97.6(a)
  395149  NM_204489.1  NP_989820.1 
lizard
(Anolis carolinensis)
Reptilia MRAS6
muscle RAS oncogene homolog
97(a)
1 ↔ 1
1(85515744-85579819)
African clawed frog
(Xenopus laevis)
Amphibia BJ068403.12   -- 80.44(n)    BJ068403.1 
zebrafish
(Danio rerio)
Actinopterygii LOC1005363171 ras-related protein M-Ras-like 77.24(n)
88.94(a)
  100536317  XM_005167761.1  XP_005167818.1 
worm
(Caenorhabditis elegans)
Secernentea ras-13
ras-21
ras-21 59(a)
(best of 2)3
60.59(n)1
64.12(a)1
  II(12345165-12347292)3
1756251  NM_065571.51  NP_497972.11 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS16
RAS26
GTPase involved in G-protein signaling in the aden...
GTP-binding protein that regulates the nitrogen st...
32(a)
30(a)
many ↔ many
many ↔ many
XV(515244-516173) YOR101W
XIV(439602-440570) YNL098C


ENSEMBL Gene Tree for MRAS (if available)
TreeFam Gene Tree for MRAS (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MRAS gene
REM12  RALA2  RRAS2  RALB2  ERAS2  RRAD2  NRAS2  REM22  
KRAS2  GEM2  RRAS22  HRAS2  
Selected SIMAP similar genes for MRAS using alignment to 4 protein entries:     RASM_HUMAN (see all proteins) (see all similar genes):
RRAS2    c-bas/has    RAP1B    RRAS    RAP1A    RAP2A
RALB    KRAS    RIT2    RALA    DKFZp547A0616    RAP2B
RAP2C    RIT1    RERG    HRAS    NRAS    RAB30

Find genes that share paralogs with MRAS           About GenesLikeMe


1 Pseudogenes.org Pseudogene for MRAS
PGOHUM00000239969


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MRAS (see all 1163)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1149665501,2
C,F--138064492(+) CTCTGC/TCCCAG 2 -- us2k11Minor allele frequency- T:0.03WA 118
rs1827598291,2
C--138064547(+) TGAAGC/TTTTTC 2 -- us2k10--------
rs574987501,2
--138064626(+) CAAAGA/TGCAGA 2 -- us2k10--------
rs1152132291,2
C,F--138064661(+) CATCCG/TCAATC 2 -- us2k11Minor allele frequency- T:0.03WA 118
rs1902396021,2
--138064830(+) CAAGAA/GGTAGC 2 -- us2k10--------
rs1827609201,2
--138064834(+) AAGTAC/GCCAGG 2 -- us2k10--------
rs1874462731,2
--138064905(+) AGTCCA/GGGAGG 2 -- us2k10--------
rs1930045821,2
--138064912(+) GAGGTC/TGAGGC 2 -- us2k10--------
rs1152193831,2
F--138064975(+) AGAGCG/AAGACT 2 -- us2k11Minor allele frequency- A:0.04NA 120
rs130859821,2
C--138065017(+) aaaaaA/GGGAGA 2 -- us2k1 tfbs3 trp30--------

HapMap Linkage Disequilibrium report for MRAS (138066539 - 138124377 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for MRAS:    About this table    
Variant IDTypeSubtypePubMed ID
nsv528349CNV Loss19592680
nsv877537CNV Gain21882294
nsv526089CNV Gain19592680
nsv428422CNV Gain+Loss18775914

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608435    OMIM disorders: --


Find genes that share disorders with MRAS           About GenesLikeMe

1 Novoseek inferred disease relationship for MRAS gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tumors 0 4 18845542 (1)

Genetic Association Database (GAD): MRAS
Human Genome Epidemiology (HuGE) Navigator: MRAS (8 documents)

Export disorders for MRAS gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MRAS gene, integrated from 10 sources (see all 38):
(articles sorted by number of sources associating them with MRAS)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution. (PubMed id 9400994)1, 2, 3, 9 Kimmelman A.... Chan A.M.-L. (Oncogene 1997)
  2. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. (PubMed id 16630891)1, 2, 9 Rodriguez-Viciana P....McCormick F. (Mol. Cell 2006)
  3. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PubMed id 21378990)1, 4 Schunkert H....Samani N.J. (Nat. Genet. 2011)
  4. Additive effect of multiple genetic variants on the risk of coronary artery disease. (PubMed id 20738937)1, 4 LluA-s-Ganella C....Elosua R. (Rev Esp Cardiol 2010)
  5. A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. (PubMed id 20971364)1, 4 Ripatti S....Kathiresan S. (Lancet 2010)
  6. New susceptibility locus for coronary artery disease on chromosome 3q22.3. (PubMed id 19198612)1, 4 Erdmann J....Schunkert H. (Nat. Genet. 2009)
  7. Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease. (PubMed id 18628988)1, 4 Li Y....Hadjigeorgiou G. (PLoS ONE 2008)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  10. Interleukin-9-induced expression of M-Ras/R-Ras3 oncogene in T-helper clones. (PubMed id 10477695)1, 2 Louahed J.... Renauld J.-C. (Blood 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 22808 HGNC: 7227 AceView: MRAS Ensembl:ENSG00000158186 euGenes: HUgn22808
ECgene: MRAS Kegg: 22808 H-InvDB: MRAS

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MRAS Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MRAS Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MRAS gene:
Search GeneIP for patents involving MRAS

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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