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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRAS Gene

protein-coding   GIFtS: 64
GCID: GC03P138066

Muscle RAS Oncogene Homolog

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Muscle RAS Oncogene Homolog1 2     R-RAS32
RRAS32 3 5     Muscle And Microspikes RAS2
Ras-Related Protein R-Ras32 3     Ras-Related Protein M-Ras2
M-RAs2     

External Ids:    HGNC: 72271   Entrez Gene: 228082   Ensembl: ENSG000001581867   OMIM: 6084355   UniProtKB: O148073   

Export aliases for MRAS gene to outside databases

Previous GC identifers: GC03P135051 GC03P138859 GC03P139348 GC03P139388 GC03P139387 GC03P139549 GC03P135441


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRAS Gene:
This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as
signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras
signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor
necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding
multiple isoforms have been observed for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for MRAS Gene: 
MRAS (muscle RAS oncogene homolog) is a protein-coding gene. Diseases associated with MRAS include noonan syndrome, and gigantism, and among its related super-pathways are Regulation of actin cytoskeleton and MAPK signaling pathway. GO annotations related to this gene include GTP binding and GTP-dependent protein binding. An important paralog of this gene is REM2.

UniProtKB/Swiss-Prot: RASM_HUMAN, O14807
Function: May serve as an important signal transducer for a novel upstream stimuli in controlling cell
proliferation. Weakly activates the MAP kinase pathway

Gene Wiki entry for MRAS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRAS gene promoter:
         HOXA9B   HOXA9   HEN1   CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): MRAS promoter sequence
   Search SABiosciences Chromatin IP Primers for MRAS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRAS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3   Ensembl cytogenetic band:  3q22.3   HGNC cytogenetic band: 3q22.3

MRAS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRAS gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P138066:  view genomic region     (about GC identifiers)

Start:
138,066,539 bp from pter      End:
138,124,377 bp from pter
Size:
57,839 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RASM_HUMAN, O14807 (See protein sequence)
Recommended Name: Ras-related protein M-Ras precursor  
Size: 208 amino acids; 23846 Da
Subunit: Interacts with RGL3. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Forms a
multiprotein complex with SHOC2, Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: B4DIK0 Q86WX8
Alternative splicing: 2 isoforms:  O14807-1   O14807-2   

Explore the universe of human proteins at neXtProt for MRAS: NX_O14807

Explore proteomics data for MRAS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14807

  • MRAS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MRAS Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001078518.1  NP_001239019.1  NP_001239020.1  NP_001239021.1  NP_001239022.1  NP_036351.3  

    ENSEMBL proteins: 
     ENSP00000289104   ENSP00000389682   ENSP00000417685   ENSP00000417092   ENSP00000419582  
     ENSP00000418356  

    Human Recombinant Protein Products for MRAS: 
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    Novus Biologicals MRAS Proteins
    Novus Biologicals MRAS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MRAS
    Cloud-Clone Corp. Proteins for MRAS 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----

    MRAS for ontologies           About GeneDecksing



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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MRAS 
    Cloud-Clone Corp. CLIAs for MRAS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry O14807

    ProtoNet protein and cluster: O14807

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RASM_HUMAN, O14807
    Similarity: Belongs to the small GTPase superfamily. Ras family


    MRAS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASM_HUMAN, O14807
    Function: May serve as an important signal transducer for a novel upstream stimuli in controlling cell
    proliferation. Weakly activates the MAP kinase pathway
    Induction: By IL9/interleukin-9, but not by IL2/interleukin-2 or IL4/interleukin-4

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005525GTP binding IEA--
    GO:0030742GTP-dependent protein binding IPI10934204
         
    MRAS for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mras):
     hematopoietic system  immune system  normal 

    MRAS for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MRAS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MRAS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRAS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MRAS 

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    hsa-miR-15a hsa-miR-424 hsa-miR-34b hsa-miR-15b hsa-miR-3163 hsa-miR-3065-3p hsa-miR-1 hsa-miR-224*
    SwitchGear 3'UTR luciferase reporter plasmidMRAS 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MRAS About   (see all 54)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3ErbB4 Pathway
    ErbB4 Pathway0.59
    LPS Stimulated MAPK Signaling0.47
    ErbB Family Pathway0.59
    UVC-Induced MAPK Signaling0.44
    Prolactin Signaling0.54
    TREM1 Pathway0.43
    Thrombopoietin Pathway0.51
    HMGB1 Pathway0.36
    4Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    ERK5 Signaling0.61
    Rac1 Pathway0.65
    eIF2 Pathway0.60
    Glioma Invasiveness0.64
    Rap1 Pathway0.57
    5GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    Estrogen Pathway0.55
    GPCR Pathway0.62
    P2Y Receptor Signaling0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for MRAS (see all 7)
        Selected targets of Oct-3/4
    G-protein signaling Rap2B regulation pathway
    G-protein signaling M-RAS regulation pathway
    Development G-Proteins mediated regulation MARK-ERK signaling
    G-protein signaling Rap1A regulation pathway

    5/108 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MRAS (see all 108)
        Fc-GammaR Pathway
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    CDK5 Pathway

    5/6 GeneGo (Thomson Reuters) Pathways for MRAS (see all 6)
        G-protein signaling M-RAS regulation pathway
    G-protein signaling Cross-talk between Ras-family GTPases
    G-protein signaling Rap1A regulation pathway
    G-protein signaling Rap2B regulation pathway
    Development G-Proteins mediated regulation MARK-ERK signaling

    3 BioSystems Pathways for MRAS
        MAPK signaling pathway
    Regulation of Actin Cytoskeleton
    IL-3 Signaling Pathway

    3 PharmGKB Pathways for MRAS
        Bisphosphonate Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Vemurafenib Pathway, Pharmacodynamics

    5         Kegg Pathways  (Kegg details for MRAS):
        MAPK signaling pathway
    Tight junction
    Regulation of actin cytoskeleton
    HTLV-I infection
    Proteoglycans in cancer


    MRAS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MRAS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for MRAS (O148072, 3 ENSP000002891044) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLXNB1O431572, 3, ENSP000002964404MINT-7228875 I2D: score=1 STRING: ENSP00000296440
    MLLT4P551962, 3, ENSP000003836234MINT-15307 MINT-15308 I2D: score=2 STRING: ENSP00000383623
    RASSF5Q8WWW03, ENSP000003474434I2D: score=2 STRING: ENSP00000347443
    RAF1P040493, ENSP000002518494I2D: score=2 STRING: ENSP00000251849
    RALGDSQ129673, ENSP000003611204I2D: score=2 STRING: ENSP00000361120
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction ----

    MRAS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MRAS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRAS (RASM)

    1 Novoseek inferred chemical compound relationship for MRAS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 34.6 1 17497936 (1)

    Search CenterWatch for drugs/clinical trials and news about MRAS / RASM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRAS gene (6 alternative transcripts): 
    NM_001085049.2  NM_001252090.1  NM_001252091.1  NM_001252092.1  NM_001252093.1  NM_012219.4  

    Unigene Cluster for MRAS:

    Muscle RAS oncogene homolog
    Hs.527021  [show with all ESTs]
    Unigene Representative Sequence: NM_012219
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000289104(uc003esh.4 uc011bmi.2 uc003esi.4 uc021xep.1 uc011bmj.2 uc021xeq.1)
    ENST00000423968 ENST00000494949 ENST00000475711 ENST00000464896 ENST00000477784
    ENST00000461114 ENST00000474559 ENST00000478647

    miRNA
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    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate MRAS (see all 45):
    hsa-miR-15a hsa-miR-424 hsa-miR-34b hsa-miR-15b hsa-miR-3163 hsa-miR-3065-3p hsa-miR-1 hsa-miR-224*
    SwitchGear 3'UTR luciferase reporter plasmidMRAS 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRAS
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    Additional mRNA sequence: 

    AF022080.1 AF493918.1 AK056337.1 AK091633.1 AK123833.1 AK124954.1 AK295640.1 AK316071.1 
    BC017733.1 BC035939.1 BC047101.1 BC047690.1 BT020057.1 CR542067.1 

    14 DOTS entries:

    DT.455948  DT.97792056  DT.97844833  DT.75110496  DT.95375945  DT.120895221  DT.95152429  DT.120895208 
    DT.120895223  DT.95375942  DT.97844831  DT.100823682  DT.120895214  DT.97790799 

    24/216 AceView cDNA sequences (see all 216):

    CR590782 BX645148 AI143993 BU509509 AA348819 AA953982 AI278050 AW304226 
    AW069319 CA421934 BM709786 AA449985 AK124954 BF792130 AI343006 AI810633 
    AI492838 AI589870 BX505620 AI350990 AI138631 BC017733 CR542067 AW173379 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MRAS (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
    SP1:        -     -     -     -     -     -     -     -                                             
    SP2:                    -     -     -     -     -     -                                             
    SP3:                                            -     -                                             
    SP4:                    -     -     -     -     -     -     -                                       
    SP5:                                -     -     -     -                                             


    ECgene alternative splicing isoforms for MRAS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRAS expression in normal human tissues (normalized intensities)      MRAS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGGGTTTAC
    MRAS Expression
    About this image


    MRAS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Conventional Dendritic Cells I Spleen
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Bone (Muscoskeletal System)
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
     
     Mesenchymal Stem Cells
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen

    See MRAS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRAS

    SOURCE GeneReport for Unigene cluster: Hs.527021

    UniProtKB/Swiss-Prot: RASM_HUMAN, O14807
    Tissue specificity: Expression highly restricted to the brain and heart

        SABiosciences Custom PCR Arrays for MRAS
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRAS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MRAS gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mras1 , 5 muscle and microspikes RAS1, 5 89.42(n)1
    96.63(a)1
      9 (51.63 cM)5
    175321  NM_008624.31  NP_032650.11 
     993854225 
    chicken
    (Gallus gallus)
    Aves MRAS1 muscle RAS oncogene homolog 83.97(n)
    97.6(a)
      395149  NM_204489.1  NP_989820.1 
    lizard
    (Anolis carolinensis)
    Reptilia MRAS6
    Uncharacterized protein
    97(a)
    1 ↔ 1
    1(85515744-85579819)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ068403.12   -- 80.44(n)    BJ068403.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005363171 ras-related protein M-Ras-like 77.24(n)
    88.94(a)
      100536317  XM_003199224.1  XP_003199272.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ras-13   -- 59(a)
    (best of 2)
      II(12345165-12347292)   --


    ENSEMBL Gene Tree for MRAS (if available)
    TreeFam Gene Tree for MRAS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRAS gene
    REM22  REM12  GEM2  RRAS22  RRAS2  ERAS2  RRAD2  
    18/77 SIMAP similar genes for MRAS using alignment to 4 protein entries:     RASM_HUMAN (see all proteins) (see all similar genes):
    RRAS2    c-bas/has    RAP1B    RRAS    RAP1A    RAP2A
    RALB    KRAS    RIT2    RALA    DKFZp547A0616    RAP2B
    RAP2C    RIT1    RERG    HRAS    NRAS    RAB30

    MRAS for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MRAS
    PGOHUM00000239969


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1163 SNPs in MRAS are shown (see all 1163)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1149665501,2
    C,F--138064492(+) CTCTGC/TCCCAG 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1827598291,2
    C--138064547(+) TGAAGC/TTTTTC 2 -- us2k10--------
    rs574987501,2
    --138064626(+) CAAAGA/TGCAGA 2 -- us2k10--------
    rs1152132291,2
    C,F--138064661(+) CATCCG/TCAATC 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1902396021,2
    --138064830(+) CAAGAA/GGTAGC 2 -- us2k10--------
    rs1827609201,2
    --138064834(+) AAGTAC/GCCAGG 2 -- us2k10--------
    rs1874462731,2
    --138064905(+) AGTCCA/GGGAGG 2 -- us2k10--------
    rs1930045821,2
    --138064912(+) GAGGTC/TGAGGC 2 -- us2k10--------
    rs1152193831,2
    F--138064975(+) AGAGCG/AAGACT 2 -- us2k11Minor allele frequency- A:0.04NA 120
    rs130859821,2
    C--138065017(+) aaaaaA/GGGAGA 2 -- us2k1 tfbs3 trp30--------

    HapMap Linkage Disequilibrium report for MRAS (138066539 - 138124377 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MRAS:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv528349CNV Loss19592680
    nsv877537CNV Gain21882294
    nsv526089CNV Gain19592680
    nsv428422CNV Gain+Loss18775914

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608435    OMIM disorders: --

    6 diseases for MRAS:    About MalaCards
    noonan syndrome    gigantism    parkinson's disease    glioblastoma
    breast cancer    neuronitis


    MRAS for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for MRAS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 4 18845542 (1)

    Genetic Association Database (GAD): MRAS
    Human Genome Epidemiology (HuGE) Navigator: MRAS (8 documents)

    Export disorders for MRAS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRAS gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with MRAS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution. (PubMed id 9400994)1, 2, 3, 9 Kimmelman A.... Chan A.M.-L. (1997)
    2. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. (PubMed id 16630891)1, 2, 9 Rodriguez-Viciana P....McCormick F. (2006)
    3. Large-scale association analysis identifies 13 new su sceptibility loci for coronary artery disease. (PubMed id 21378990)1, 4 Schunkert H....Samani N.J. (2011)
    4. Additive effect of multiple genetic variants on the r isk of coronary artery disease. (PubMed id 20738937)1, 4 LluA-s-Ganella C....Elosua R. (2010)
    5. A multilocus genetic risk score for coronary heart di sease: case-control and prospective cohort analyses. (PubMed id 20971364)1, 4 Ripatti S....Kathiresan S. (2010)
    6. New susceptibility locus for coronary artery disease on chromosome 3q22.3. (PubMed id 19198612)1, 4 Erdmann J....Schunkert H. (2009)
    7. Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease. (PubMed id 18628988)1, 4 Li Y....Hadjigeorgiou G. (2008)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Interleukin-9-induced expression of M-Ras/R-Ras3 oncogene in T-helper clones. (PubMed id 10477695)1, 2 Louahed J.... Renauld J.-C. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22808 HGNC: 7227 AceView: MRAS Ensembl:ENSG00000158186 euGenes: HUgn22808
    ECgene: MRAS Kegg: 22808 H-InvDB: MRAS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRAS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MRAS Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRAS gene:
    Search GeneIP for patents involving MRAS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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