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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRAS Gene

protein-coding   GIFtS: 62
GCID: GC03P138066

muscle RAS oncogene homolog
 Explore 6 diseases affiliated with
MRAS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MRAS    

Aliases
for MRAS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Muscle RAS Oncogene Homolog1 2     Ras-Related Protein R-Ras32 3
RRAS31 2 3 5     Muscle And Microspikes RAS2
M-RAs1 2     Ras-Related Protein M-Ras2
R-RAS31 2     

External Ids:    HGNC: 72271   Entrez Gene: 228082   Ensembl: ENSG000001581867   OMIM: 6084355   UniProtKB: O148073   

Export aliases for MRAS gene to outside databases

Previous GC identifers: GC03P135051 GC03P138859 GC03P139348 GC03P139388 GC03P139387 GC03P139549 GC03P135441


Summaries
for MRAS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MRAS:
This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal
transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has
been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and
MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed
for this gene. (provided by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: RASM_HUMAN, O14807
Function: May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation.
Weakly activates the MAP kinase pathway

Gene Wiki entry for MRAS


Genomic Views
for MRAS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRAS gene promoter:
         HOXA9B   HOXA9   HEN1   CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): MRAS promoter sequence
   Search SABiosciences Chromatin IP Primers for MRAS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRAS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3   Ensembl cytogenetic band:  3q22.3   HGNC cytogenetic band: 3q22.3

MRAS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRAS gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P138066:  view genomic region     (about GC identifiers)

Start:
 138,066,539 bp from pter      End:
 138,124,377 bp from pter
Size:
 57,839 bases      Orientation:
 plus strand

Proteins
for MRAS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RASM_HUMAN, O14807 (See protein sequence)
Recommended Name: Ras-related protein M-Ras precursor  
Size: 208 amino acids; 23846 Da
Subunit: Interacts with RGL3. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Forms a
multiprotein complex with SHOC2, Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: B4DIK0 Q86WX8
Alternative splicing: 2 isoforms:  O14807-1   O14807-2   

Explore the universe of human proteins at neXtProt for MRAS: NX_O14807

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14807

    • MRAS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001078518.1  NP_001239019.1  NP_001239020.1  NP_001239021.1  NP_001239022.1  NP_036351.3  

    ENSEMBL proteins: 
     ENSP00000289104   ENSP00000389682   ENSP00000417685   ENSP00000417092   ENSP00000419582  
     ENSP00000418356  

    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MRAS Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): MRAS
    OriGene Protein Over-expression Lysate (see all 3): MRAS
    OriGene Custom Protein Services for MRAS 
    GenScript Custom Purified and Recombinant Proteins Services for MRAS
    Novus Biologicals MRAS Proteins
    Novus Biologicals MRAS Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MRAS
    Uscn Proteins for MRAS

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----


    MRAS for ontologies           About GeneDecksing



    MRAS Antibody Products: 
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    Novus Biologicals MRAS Antibodies
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    Uscn Antibodies for MRAS
    ThermoFisher Antibodies for MRAS

    Assay Products for MRAS: 
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    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MRAS
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MRAS

    Protein Domains /
    Families
    for MRAS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MRAS for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry O14807

    ProtoNet protein and cluster: O14807

    2 Blocks protein families:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RASM_HUMAN, O14807
    Similarity: Belongs to the small GTPase superfamily. Ras family


    Function
    for MRAS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RASM_HUMAN, O14807
    Function: May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation.
    Weakly activates the MAP kinase pathway
    Induction: By IL9/interleukin-9, but not by IL2/interleukin-2 or IL4/interleukin-4

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): MRAS
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRAS
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate MRAS (see all 45):
    hsa-miR-15a hsa-miR-424 hsa-miR-34b hsa-miR-15b hsa-miR-3163 hsa-miR-3065-3p hsa-miR-1 hsa-miR-224*
    SwitchGear 3'UTR luciferase reporter plasmid: MRAS 3' UTR sequence
    Inhib. RNA
    Products:            		EMD Millipore RNAi Products for the Analysis of MRAS Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRAS (see all 7)
    OriGene shRNA RFP: MRAS
    OriGene siRNA: MRAS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRAS

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MRAS

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRAS (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRAS (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MRAS (NM_012219)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRAS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRAS 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MRAS
    Search LifeMap BioReagents cell lines for MRAS

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRAS

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--
    GO:0030742GTP-dependent protein binding IPI10934204


    MRAS for ontologies           About GeneDecksing


    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mras):
     hematopoietic system  immune system  normal 

    MRAS for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MRAS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/53 super-pathways (see all 53) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1ErbB4 Pathway
    8/11 pathways (see all 11)
    		ErbB4 Pathway1.00
    		Thrombopoietin Pathway0.43
    		ErbB Family Pathway0.59
    		LPS Stimulated MAPK Signaling0.36
    		Prolactin Signaling0.54
    		TREM1 Pathway0.32
    		ErbB2-ErbB3 Heterodimers0.47
    		HMGB1 Pathway0.32
    2GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Paxillin Interactions0.53
    		Breast Cancer Regulation by Stathmin10.58
    		P2Y Receptor Signaling0.38
    3CCR3 Pathway in Eosinophils
    		CCR3 Pathway in Eosinophils1.00
    		CXCR4 Pathway0.39
    		VEGF and S-1P Signaling0.44
    		Alpha-Adrenergic Signaling0.31
    		fMLP Pathway0.43
    		Internalin Pathway0.19
    4Apoptotic Pathways in Synovial Fibroblasts
    		PPAR Pathway0.66
    		Rac1 Pathway0.58
    		ERK5 Signaling0.61
    		Glioma Invasiveness0.54
    		eIF2 Pathway0.60
    		Rap1 Pathway0.42
    5TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		MAPK Family Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		JAK-STAT Pathway0.57

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/7 EMD Millipore Pathways for MRAS (see all 7)
        Selected targets of Oct-3/4
    G-protein signaling Rap2B regulation pathway
    G-protein signaling M-RAS regulation pathway
    Development G-Proteins mediated regulation MARK-ERK signaling
    G-protein signaling Rap1A regulation pathway

    5/108 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MRAS (see all 108)
        Fc-GammaR Pathway
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    CDK5 Pathway

    5/6 GeneGo (Thomson Reuters) Pathways for MRAS (see all 6)
        G-protein signaling M-RAS regulation pathway
    G-protein signaling Cross-talk between Ras-family GTPases
    G-protein signaling Rap1A regulation pathway
    G-protein signaling Rap2B regulation pathway
    Development G-Proteins mediated regulation MARK-ERK signaling

    3 BioSystems Pathways for MRAS 
        MAPK signaling pathway
    IL-3 Signaling Pathway
    Regulation of Actin Cytoskeleton

    3 PharmGKB Pathways for MRAS
        Bisphosphonate Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Vemurafenib Pathway, Pharmacodynamics

    3         Kegg Pathways  (Kegg details for MRAS):
        MAPK signaling pathway
    Tight junction
    Regulation of actin cytoskeleton


    MRAS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MRAS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for MRAS (O148072, 3 ENSP000002891044) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLXNB1O431572, 3, ENSP000002964404MINT-7228875 I2D: score=1 STRING: ENSP00000296440
    MLLT4P551962, 3, ENSP000003836234MINT-15307 MINT-15308 I2D: score=2 STRING: ENSP00000383623
    RASSF5Q8WWW03, ENSP000003474434I2D: score=2 STRING: ENSP00000347443
    RAF1P040493, ENSP000002518494I2D: score=2 STRING: ENSP00000251849
    RALGDSQ129673, ENSP000003611204I2D: score=2 STRING: ENSP00000361120
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007264small GTPase mediated signal transduction ----
    GO:0007265Ras protein signal transduction TAS10446149
    GO:0007275multicellular organismal development TAS10446149
    GO:0007517muscle organ development TAS9395237


    MRAS for ontologies           About GeneDecksing



    Drugs & Compounds
    for MRAS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MRAS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRAS
    1 Novoseek chemical compound relationship for MRAS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 34.6 1 17497936 (1)

    Search CenterWatch for drugs/clinical trials and news about MRAS / RASM 

    Transcripts
    for MRAS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MRAS gene (6 alternative transcripts): 
    NM_001085049.2  NM_001252090.1  NM_001252091.1  NM_001252092.1  NM_001252093.1  NM_012219.4  

    Unigene Cluster for MRAS:

    Muscle RAS oncogene homolog
    Hs.527021  [show with all ESTs]
    Unigene Representative Sequence: NM_012219
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000289104(uc003esh.4 uc011bmi.2 uc003esi.4 uc021xep.1 uc011bmj.2 uc021xeq.1)
    ENST00000423968 ENST00000494949 ENST00000475711 ENST00000464896 ENST00000477784
    ENST00000461114 ENST00000474559 ENST00000478647

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRAS
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate MRAS (see all 45):
    hsa-miR-15a hsa-miR-424 hsa-miR-34b hsa-miR-15b hsa-miR-3163 hsa-miR-3065-3p hsa-miR-1 hsa-miR-224*
    SwitchGear 3'UTR luciferase reporter plasmid: MRAS 3' UTR sequence
    Inhib. RNA
    Products:             		EMD Millipore RNAi Products for the Analysis of MRAS Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRAS (see all 7)
    OriGene shRNA RFP: MRAS
    OriGene siRNA: MRAS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRAS
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): MRAS (NM_012219)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRAS 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRAS

    Additional cDNA sequence: 

    AF022080.1 AF493918.1 AK056337.1 AK091633.1 AK123833.1 AK124954.1 AK295640.1 AK316071.1 
    BC017733.1 BC035939.1 BC047101.1 BC047690.1 BT020057.1 CR542067.1 

    14 DOTS entries:

    DT.455948  DT.97792056  DT.97844833  DT.95375945  DT.75110496  DT.120895221  DT.95152429  DT.120895208 
    DT.120895214  DT.120895223  DT.95375942  DT.97844831  DT.100823682  DT.97790799 

    24/216 AceView cDNA sequences (see all 216):

    CA397891 BX503289 AW304226 CA421934 AW173379 CA388791 AI278050 AI394207 
    AA317021 AW008420 AI079409 AF493918 BX505620 AI143993 AI373696 AI015651 
    CR542067 BX645148 CF529950 AI148638 BF437869 AW167766 AK123833 CD723830 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MRAS (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
    SP1:        -     -     -     -     -     -     -     -                                             
    SP2:                    -     -     -     -     -     -                                             
    SP3:                                            -     -                                             
    SP4:                    -     -     -     -     -     -     -                                       
    SP5:                                -     -     -     -                                             


    ECgene alternative splicing isoforms for MRAS

    Expression
    for MRAS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRAS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCGGGTTTAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MRAS expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVisceral White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MRAS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRAS

    SOURCE GeneReport for Unigene cluster: Hs.527021

    UniProtKB/Swiss-Prot: RASM_HUMAN, O14807
    Tissue specificity: Expression highly restricted to the brain and heart

        SABiosciences Custom PCR Arrays for MRAS
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRAS
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRAS

    Orthologs
    for MRAS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MRAS gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MRAS1 muscle RAS oncogene homolog 83.97(n)
    97.6(a)    		   395149  NM_204489.1  NP_989820.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MRAS6
    		 --
    		 97(a)
    		 1 ↔ 1
    		 1(85517547-85538285)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BJ068403.12   -- 80.44(n)    BJ068403.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005363171 ras-related protein M-Ras-like 77.24(n)
    88.94(a)    		   100536317  XM_003199224.1  XP_003199272.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 69(a)
    		 1 ↔ 1
    		 Group13.2(381736-382551)
    worm
    (Caenorhabditis elegans)    		 Secernentea ras-13   -- 59(a)
    (best of 2)    		   II(12345165-12347292)   --


    ENSEMBL Gene Tree for MRAS (if available)
    TreeFam Gene Tree for MRAS (if available) 

    Paralogs
    for MRAS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRAS gene
    REM12  RALA2  RIT22  RIT12  RRAS2  ERAS2  RALB2  NRAS2  
    RRAD2  REM22  KRAS2  GEM2  RRAS22  HRAS2  
    18/77 SIMAP similar genes for MRAS using alignment to 4 protein entries:     RASM_HUMAN (see all proteins) (see all similar genes):
    RRAS2    c-bas/has    RAP1B    RRAS    RAP1A    RAP2A
    RALB    KRAS    RIT2    RALA    DKFZp547A0616    RAP2B
    RAP2C    RIT1    RERG    HRAS    NRAS    RAB30

    MRAS for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MRAS
    PGOHUM00000239969


    Genomic Variants
    for MRAS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/996 NCBI SNPs in MRAS are shown (see all 996)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1149665501,2
    		C,F,--138064492(+) CTCTGC/TCCCAG 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1827598291,2
    		--138064547(+) TGAAGC/TTTTTC 2 -- us2k10--------
    rs574987501,2
    		--138064626(+) CAAAGA/TGCAGA 2 -- us2k10--------
    rs1152132291,2
    		C,F,--138064661(+) CATCCG/TCAATC 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1902396021,2
    		--138064830(+) CAAGAA/GGTAGC 2 -- us2k10--------
    rs1827609201,2
    		--138064834(+) AAGTAC/GCCAGG 2 -- us2k10--------
    rs1874462731,2
    		--138064905(+) AGTCCA/GGGAGG 2 -- us2k10--------
    rs1930045821,2
    		--138064912(+) GAGGTC/TGAGGC 2 -- us2k10--------
    rs1152193831,2
    		F,--138064975(+) AGAGCG/AAGACT 2 -- us2k11Minor allele frequency- A:0.04NA 120
    rs130859821,2
    		C--138065017(+) AAAAAA/GGGAGA 2 -- us2k1 tfbs3 trp30--------

    HapMap Linkage Disequilibrium report for MRAS (138066539 - 138124377 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MRAS: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRAS
    DNA2.0 Custom Variant and Variant Library Synthesis for MRAS

    Disorders / Diseases
    for MRAS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MRAS for disorders           About GeneDecksing

    OMIM gene information: 608435    OMIM disorders: --

    6 diseases for MRAS:    About MalaCards
    noonan syndrome    gigantism    parkinson's disease    neuronitis
    glioblastoma    breast cancer

    1 Novoseek disease relationship for MRAS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 4 18845542 (1)

    Human Genome Epidemiology (HuGE) Navigator: MRAS (8 documents)

    Export disorders for MRAS gene to outside databases

    Publications
    for MRAS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRAS gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with MRAS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution. (PubMed id 9400994)1, 2, 3, 9 Kimmelman A.... Chan A.M.-L. (1997)
    2. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. (PubMed id 16630891)1, 2, 9 Rodriguez-Viciana P....McCormick F. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Interleukin-9-induced expression of M-Ras/R-Ras3 oncogene in T-helper clones. (PubMed id 10477695)1, 2 Louahed J.... Renauld J.-C. (1999)
    6. M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6. (PubMed id 10446149)1, 3 Quilliam L.A....Bi C. (1999)
    7. R-Ras3, a brain-specific Ras-related protein, activates Akt and promotes cell survival in PC12 cells. (PubMed id 10803462)1, 9 Kimmelman A.C....Chan A.M. (2000)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Large-scale association analysis identifies 13 new su sceptibility loci for coronary artery disease. (PubMed id 21378990)1 Schunkert H....Samani N.J. (2011)
    10. Additive effect of multiple genetic variants on the r isk of coronary artery disease. (PubMed id 20738937)1 LluA-s-Ganella C....Elosua R. (2010)

    External Searches for MRAS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MRAS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22808 HGNC: 7227 AceView: MRAS Ensembl:ENSG00000158186 euGenes: HUgn22808
    ECgene: MRAS Kegg: 22808 H-InvDB: MRAS

    Other Databases showing MRAS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MRAS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRAS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MRAS Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MRAS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MRAS gene:
    Search GeneIP for patents involving MRAS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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