Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRAS Gene

Aliases for MRAS Gene

  • Muscle RAS Oncogene Homolog 2 3 5
  • Ras-Related Protein R-Ras3 3 4
  • RRAS3 3 4
  • Muscle And Microspikes RAS 3
  • R-RAS3 3
  • M-RAs 3

External Ids for MRAS Gene

Previous GeneCards Identifiers for MRAS Gene

  • GC03P135051
  • GC03P138859
  • GC03P139348
  • GC03P139388
  • GC03P139387
  • GC03P139549
  • GC03P138066
  • GC03P135441

Summaries for MRAS Gene

Entrez Gene Summary for MRAS Gene

  • This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for MRAS Gene

MRAS (Muscle RAS Oncogene Homolog) is a Protein Coding gene. Diseases associated with MRAS include Vertebral Artery Occlusion and Vertebrobasilar Insufficiency. Among its related pathways are IL-2 Pathway and HTLV-I infection. GO annotations related to this gene include GTP binding and GTP-dependent protein binding. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for MRAS Gene

  • May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.

Gene Wiki entry for MRAS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRAS Gene

Genomics for MRAS Gene

Regulatory Elements for MRAS Gene

Enhancers for MRAS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRAS on UCSC Golden Path with GeneCards custom track

Promoters for MRAS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRAS on UCSC Golden Path with GeneCards custom track

Genomic Location for MRAS Gene

138,347,648 bp from pter
138,405,535 bp from pter
57,888 bases
Plus strand

Genomic View for MRAS Gene

Genes around MRAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRAS Gene

Proteins for MRAS Gene

  • Protein details for MRAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein M-Ras
    Protein Accession:
    Secondary Accessions:
    • B4DIK0
    • Q86WX8

    Protein attributes for MRAS Gene

    208 amino acids
    Molecular mass:
    23846 Da
    Quaternary structure:
    • Interacts with RGL3. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Forms a multiprotein complex with SHOC2, Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC).

    Alternative splice isoforms for MRAS Gene


neXtProt entry for MRAS Gene

Proteomics data for MRAS Gene at MOPED

Post-translational modifications for MRAS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MRAS (MRas)

No data available for DME Specific Peptides for MRAS Gene

Domains & Families for MRAS Gene

Gene Families for MRAS Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Ras family.
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with MRAS: view

Function for MRAS Gene

Molecular function for MRAS Gene

UniProtKB/Swiss-Prot Function:
May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.
UniProtKB/Swiss-Prot Induction:
By IL9/interleukin-9, but not by IL2/interleukin-2 or IL4/interleukin-4.
genes like me logo Genes that share phenotypes with MRAS: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MRAS

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRAS Gene

Localization for MRAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRAS Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for MRAS Gene COMPARTMENTS Subcellular localization image for MRAS gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for MRAS Gene

Pathways & Interactions for MRAS Gene

genes like me logo Genes that share pathways with MRAS: view

SIGNOR curated interactions for MRAS Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006913 nucleocytoplasmic transport IEA --
GO:0007165 signal transduction IEA --
GO:0007517 muscle organ development TAS 9395237
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with MRAS: view

Drugs & Compounds for MRAS Gene

(1) Additional Compounds for MRAS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MRAS: view

Transcripts for MRAS Gene

Unigene Clusters for MRAS Gene

Muscle RAS oncogene homolog:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRAS Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - - - -
SP5: - - - -
SP6: - -

Relevant External Links for MRAS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRAS Gene

mRNA expression in normal human tissues for MRAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRAS Gene

This gene is overexpressed in Brain (14.9), Spinal cord (7.3), Frontal cortex (6.7), Retina (6.2), and Nasopharynx (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRAS Gene

SOURCE GeneReport for Unigene cluster for MRAS Gene Hs.527021

mRNA Expression by UniProt/SwissProt for MRAS Gene

Tissue specificity: Expression highly restricted to the brain and heart.
genes like me logo Genes that share expression patterns with MRAS: view

Protein tissue co-expression partners for MRAS Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for MRAS Gene

Orthologs for MRAS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRAS Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRAS 35
  • 94.39 (n)
  • 99.52 (a)
  • 100 (a)
(Canis familiaris)
Mammalia MRAS 35
  • 93.91 (n)
  • 100 (a)
  • 100 (a)
(Mus musculus)
Mammalia Mras 35
  • 89.42 (n)
  • 96.63 (a)
Mras 16
Mras 36
  • 97 (a)
(Pan troglodytes)
Mammalia MRAS 35
  • 99.52 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Mras 35
  • 90.06 (n)
  • 97.6 (a)
(Monodelphis domestica)
Mammalia MRAS 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia MRAS 36
  • 95 (a)
(Gallus gallus)
Aves MRAS 35
  • 83.97 (n)
  • 97.6 (a)
  • 98 (a)
(Anolis carolinensis)
Reptilia MRAS 36
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496446 35
  • 79.81 (n)
  • 92.31 (a)
(Danio rerio)
Actinopterygii LOC100536317 35
  • 77.24 (n)
  • 88.94 (a)
  • 86 (a)
(Caenorhabditis elegans)
Secernentea ras-1 37
  • 59 (a)
ras-2 37
  • 58 (a)
ras-2 35
  • 60.59 (n)
  • 64.12 (a)
ras-2 36
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS1 36
  • 32 (a)
RAS2 36
  • 30 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2555 35
Species with no ortholog for MRAS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRAS Gene

Gene Tree for MRAS (if available)
Gene Tree for MRAS (if available)

Paralogs for MRAS Gene

Paralogs for MRAS Gene Pseudogenes for MRAS Gene

genes like me logo Genes that share paralogs with MRAS: view

Variants for MRAS Gene

Sequence variations from dbSNP and Humsavar for MRAS Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1127 -- 138,355,023(+) caagc(A/G)atcct intron-variant
rs1128 -- 138,355,060(+) gatta(C/T)aggca intron-variant
rs10471 -- 138,405,373(+) ATTAT(A/T)GTGCG utr-variant-3-prime
rs40005 -- 138,362,209(+) TCCTC(A/G)GTTCT intron-variant
rs40412 -- 138,362,073(+) GGCAC(C/T)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRAS Gene

Variant ID Type Subtype PubMed ID
nsv428422 CNV Gain+Loss 18775914
nsv877537 CNV Gain 21882294
nsv528349 CNV Loss 19592680
nsv526089 CNV Gain 19592680

Variation tolerance for MRAS Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRAS Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRAS Gene

Disorders for MRAS Gene

MalaCards: The human disease database

(6) MalaCards diseases for MRAS Gene - From: DISEASES

Disorder Aliases PubMed IDs
vertebral artery occlusion
  • occlusion and stenosis of vertebral artery
vertebrobasilar insufficiency
  • vertebro-basilar insufficiency
  • causalgia nos
cerebral arterial disease
  • cerebral arterial diseases
benign paroxysmal positional nystagmus
  • benign paroxysmal positional vertigo
- elite association - COSMIC cancer census association via MalaCards
Search MRAS in MalaCards View complete list of genes associated with diseases

Relevant External Links for MRAS

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MRAS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRAS Gene

Publications for MRAS Gene

  1. Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution. (PMID: 9400994) Kimmelman A. … Chan A.M.-L. (Oncogene 1997) 2 3 4 23 67
  2. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. (PMID: 16630891) Rodriguez-Viciana P. … McCormick F. (Mol. Cell 2006) 3 23
  3. R-Ras3, a brain-specific Ras-related protein, activates Akt and promotes cell survival in PC12 cells. (PMID: 10803462) Kimmelman A.C. … Chan A.M. (Oncogene 2000) 3 23
  4. M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6. (PMID: 10446149) Quilliam L.A. … Bi C. (J. Biol. Chem. 1999) 2 3
  5. Genetic insight into the role of MRAS in coronary artery disease risk. (PMID: 25800439) Liu L. … Cui W. (Gene 2015) 3

Products for MRAS Gene

Sources for MRAS Gene