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Aliases for MRAS Gene

Aliases for MRAS Gene

  • Muscle RAS Oncogene Homolog 2 3
  • RRAS3 3 4 6
  • Ras-Related Protein R-Ras3 3 4
  • Muscle And Microspikes RAS 3
  • Ras-Related Protein M-Ras 3
  • R-RAS3 3
  • M-RAs 3

External Ids for MRAS Gene

Summaries for MRAS Gene

Entrez Gene Summary for MRAS Gene

  • This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for MRAS Gene

MRAS (Muscle RAS Oncogene Homolog) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and GPCR Pathway. GO annotations related to this gene include GTP binding and GTP-dependent protein binding. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for MRAS Gene

  • May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.

Gene Wiki entry for MRAS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRAS Gene

Genomics for MRAS Gene

Genomic Location for MRAS Gene

Start:
138,347,648 bp from pter
End:
138,405,535 bp from pter
Size:
57,888 bases
Orientation:
Plus strand

Genomic View for MRAS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRAS Gene

Regulatory Elements for MRAS Gene

Proteins for MRAS Gene

  • Protein details for MRAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14807-RASM_HUMAN
    Recommended name:
    Ras-related protein M-Ras
    Protein Accession:
    O14807
    Secondary Accessions:
    • B4DIK0
    • Q86WX8

    Protein attributes for MRAS Gene

    Size:
    208 amino acids
    Molecular mass:
    23846 Da
    Quaternary structure:
    • Interacts with RGL3. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Forms a multiprotein complex with SHOC2, Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC).

    Alternative splice isoforms for MRAS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRAS Gene

Proteomics data for MRAS Gene at MOPED

Post-translational modifications for MRAS Gene

No Post-translational modifications

No data available for DME Specific Peptides for MRAS Gene

Domains for MRAS Gene

Graphical View of Domain Structure for InterPro Entry

O14807

UniProtKB/Swiss-Prot:

RASM_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Ras family.:
    • O14807
genes like me logo Genes that share domains with MRAS: view

No data available for Gene Families for MRAS Gene

Function for MRAS Gene

Molecular function for MRAS Gene

UniProtKB/Swiss-Prot Function: May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.
UniProtKB/Swiss-Prot Induction: By IL9/interleukin-9, but not by IL2/interleukin-2 or IL4/interleukin-4

Gene Ontology (GO) - Molecular Function for MRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 10446149
GO:0005525 GTP binding IEA --
GO:0030742 GTP-dependent protein binding IPI 10934204
genes like me logo Genes that share ontologies with MRAS: view

Phenotypes for MRAS Gene

genes like me logo Genes that share phenotypes with MRAS: view

miRNA for MRAS Gene

miRTarBase miRNAs that target MRAS

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRAS Gene

Localization for MRAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRAS Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRAS Gene COMPARTMENTS Subcellular localization image for MRAS gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for MRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MRAS: view

Pathways for MRAS Gene

genes like me logo Genes that share pathways with MRAS: view

Gene Ontology (GO) - Biological Process for MRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with MRAS: view

Compounds for MRAS Gene

(1) Novoseek inferred chemical compound relationships for MRAS Gene

Compound -log(P) Hits PubMed IDs
gtp 34.6 1
genes like me logo Genes that share compounds with MRAS: view

Transcripts for MRAS Gene

Unigene Clusters for MRAS Gene

Muscle RAS oncogene homolog:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRAS Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - - - -
SP5: - - - -
SP6: - -
SP7:

Relevant External Links for MRAS Gene

GeneLoc Exon Structure for
MRAS
ECgene alternative splicing isoforms for
MRAS

Expression for MRAS Gene

mRNA expression in normal human tissues for MRAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRAS Gene

SOURCE GeneReport for Unigene cluster for MRAS Gene Hs.527021

mRNA Expression by UniProt/SwissProt for MRAS Gene

O14807-RASM_HUMAN
Tissue specificity: Expression highly restricted to the brain and heart
genes like me logo Genes that share expressions with MRAS: view

No data available for mRNA differential expression in normal tissues for MRAS Gene

Orthologs for MRAS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRAS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRAS 35
  • 99.52 (n)
  • 100 (a)
MRAS 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRAS 35
  • 94.39 (n)
  • 99.52 (a)
MRAS 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRAS 35
  • 93.91 (n)
  • 100 (a)
MRAS 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mras 35
  • 89.42 (n)
  • 96.63 (a)
Mras 16
Mras 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRAS 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRAS 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mras 35
  • 90.06 (n)
  • 97.6 (a)
chicken
(Gallus gallus)
Aves MRAS 35
  • 83.97 (n)
  • 97.6 (a)
MRAS 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRAS 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496446 35
  • 79.81 (n)
  • 92.31 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100536317 35
  • 77.24 (n)
  • 88.94 (a)
MRAS 36
  • 86 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ras-2 35
  • 60.59 (n)
  • 64.12 (a)
ras-2 36
  • 55 (a)
OneToOne
ras-1 37
  • 59 (a)
ras-2 37
  • 58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS1 36
  • 32 (a)
ManyToMany
RAS2 36
  • 30 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2555 35
Species with no ortholog for MRAS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRAS Gene

ENSEMBL:
Gene Tree for MRAS (if available)
TreeFam:
Gene Tree for MRAS (if available)

Paralogs for MRAS Gene

Paralogs for MRAS Gene

Pseudogenes.org Pseudogenes for MRAS Gene

genes like me logo Genes that share paralogs with MRAS: view

Variants for MRAS Gene

Sequence variations from dbSNP and Humsavar for MRAS Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1127 -- 138,355,023(+) caagc(A/G)atcct intron-variant
rs1128 -- 138,355,060(+) gatta(C/T)aggca intron-variant
rs10471 -- 138,405,373(+) ATTAT(A/T)GTGCG utr-variant-3-prime
rs40005 -- 138,362,209(+) TCCTC(A/G)GTTCT intron-variant
rs40412 -- 138,362,073(+) GGCAC(C/T)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRAS Gene

Variant ID Type Subtype PubMed ID
nsv428422 CNV Gain+Loss 18775914
nsv877537 CNV Gain 21882294
nsv528349 CNV Loss 19592680
nsv526089 CNV Gain 19592680

Relevant External Links for MRAS Gene

HapMap Linkage Disequilibrium report
MRAS
Human Gene Mutation Database (HGMD)
MRAS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRAS Gene

Disorders for MRAS Gene

(1) Novoseek inferred disease relationships for MRAS Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for MRAS

Genetic Association Database (GAD)
MRAS
Human Genome Epidemiology (HuGE) Navigator
MRAS
genes like me logo Genes that share disorders with MRAS: view

No data available for UniProtKB/Swiss-Prot for MRAS Gene

Publications for MRAS Gene

  1. Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution. (PMID: 9400994) Kimmelman A. … Chan A.M.-L. (Oncogene 1997) 2 3 4 23
  2. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. (PMID: 16630891) Rodriguez-Viciana P. … McCormick F. (Mol. Cell 2006) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease. (PMID: 18628988) Li Y. … Hadjigeorgiou G. (PLoS ONE 2008) 3 48

Products for MRAS Gene

Sources for MRAS Gene

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