Aliases for MRAP2 Gene
External Ids for MRAP2 Gene
Previous HGNC Symbols for MRAP2 Gene
Previous GeneCards Identifiers for MRAP2 Gene
GeneCards Summary for MRAP2 Gene
MRAP2 (Melanocortin 2 Receptor Accessory Protein 2) is a Protein Coding gene. Diseases associated with MRAP2 include obesity bmiq18 and obesity due to melanocortin 4 receptor deficiency. GO annotations related to this gene include type 3 melanocortin receptor binding and type 1 melanocortin receptor binding.
UniProtKB/Swiss-Prot for MRAP2 Gene
Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.