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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRAP2 Gene

protein-coding   GIFtS: 42
GCID: GC06P084743

Melanocortin 2 Receptor Accessory Protein 2

(Previous name: chromosome 6 open reading frame 117)
(Previous symbol: C6orf117)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Melanocortin 2 Receptor Accessory Protein 21 2
C6orf1171 2 3
Chromosome 6 Open Reading Frame 1171
RP11-51G5.22
bA51G5.22
Melanocortin-2 Receptor Accessory Protein 22

External Ids:    HGNC: 212321   Entrez Gene: 1126092   Ensembl: ENSG000001353247   OMIM: 6154105   UniProtKB: Q96G303   

Export aliases for MRAP2 gene to outside databases

Previous GC identifers: GC06P084801 GC06P081973


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MRAP2 Gene: 
MRAP2 (melanocortin 2 receptor accessory protein 2) is a protein-coding gene. Diseases associated with MRAP2 include familial glucocorticoid deficiency. GO annotations related to this gene include type 1 melanocortin receptor binding and type 3 melanocortin receptor binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007299.13  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRAP2 gene promoter:
         USF1   SREBP-1c   Brachyury   SREBP-1b   SREBP-1a   POU2F1   POU2F1b   POU2F1a   USF-1   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRAP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRAP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.2   Ensembl cytogenetic band:  6q14.2   HGNC cytogenetic band: 6q14.3

MRAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRAP2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P084743:  view genomic region     (about GC identifiers)

Start:
84,743,420 bp from pter      End:
84,800,606 bp from pter
Size:
57,187 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MRAP2_HUMAN, Q96G30 (See protein sequence)
Recommended Name: Melanocortin-2 receptor accessory protein 2  
Size: 205 amino acids; 23548 Da
Secondary accessions: A8K9M1 Q8IXM9 Q8N2D1

Explore the universe of human proteins at neXtProt for MRAP2: NX_Q96G30

Explore proteomics data for MRAP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96G30

  • MRAP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MRAP2 Protein Expression
    REFSEQ proteins: NP_612418.2  
    ENSEMBL proteins: 
     ENSP00000257776  

    Human Recombinant Protein Products for MRAP2: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MRAP2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA19329486
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane IDA19329486
    GO:0016021integral to membrane IEA--

    MRAP2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96G30


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031780corticotropin hormone receptor binding IPI19329486
    GO:0031781type 3 melanocortin receptor binding IPI19329486
    GO:0031782type 4 melanocortin receptor binding IPI19329486
    GO:0031783type 5 melanocortin receptor binding IPI19329486
    GO:0070996type 1 melanocortin receptor binding IPI19329486
         
    MRAP2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MRAP2:
     Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mrap2):
     adipose tissue  growth/size  homeostasis/metabolism 

    MRAP2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MRAP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MRAP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRAP2 
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    SwitchGear 3'UTR luciferase reporter plasmidMRAP2 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRAP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for MRAP2 (ENSP000002577764) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MC2RENSP000003338214STRING: ENSP00000333821
    MC3RENSP000002439114STRING: ENSP00000243911
    MC4RENSP000002997664STRING: ENSP00000299766
    MC5RENSP000003180774STRING: ENSP00000318077
    MRAPENSP000003066974STRING: ENSP00000306697
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process ISS--
    GO:0007631feeding behavior ISS--
    GO:0030819positive regulation of cAMP biosynthetic process IDA19329486
    GO:0034394protein localization to cell surface IDA19329486
    GO:0097009energy homeostasis ISS--

    MRAP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRAP2

    Search CenterWatch for drugs/clinical trials and news about MRAP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRAP2 gene: 
    NM_138409.2  

    Unigene Cluster for MRAP2:

    Melanocortin 2 receptor accessory protein 2
    Hs.370055  [show with all ESTs]
    Unigene Representative Sequence: NM_138409
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000257776(uc003pkg.4 uc010kbo.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRAP2
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MRAP2 (see all 10):
    hsa-miR-7-2* hsa-miR-578 hsa-miR-3647-3p hsa-miR-105 hsa-miR-1912 hsa-miR-1305 hsa-miR-7-1* hsa-miR-378*
    SwitchGear 3'UTR luciferase reporter plasmidMRAP2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRAP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRAP2

    Additional mRNA sequence: 

    AJ420596.1 AK090775.1 AK292736.1 AK307078.1 BC010003.2 BC039855.1 

    2 DOTS entries:

    DT.100016423  DT.97785541 

    24/64 AceView cDNA sequences (see all 64):

    BU629097 BF446244 AW957353 NM_138409 BQ417370 AI694370 CR609200 AX746611 
    BC039855 BC010003 BF221531 AA350098 AK090775 BQ287913 AA565808 AA947918 
    BM128672 BX451752 BV202145 BP340257 BE312885 BM855453 BG527611 BU786752 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRAP2 expression in normal human tissues (normalized intensities)      MRAP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAAGCTGTT
    MRAP2 Expression
    About this image


    MRAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
             Knee Normal Human Articular chondrocytes (knNHAC)   
     
     Adipose (Muscoskeletal System)
             HyStem+BMP4-induced 7SMOO32 cells
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
     
     Spinal Cord (Nervous System)

     -- (Endocrine System)
             pituitary gland   

    See MRAP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRAP2

    SOURCE GeneReport for Unigene cluster: Hs.370055
        SABiosciences Custom PCR Arrays for MRAP2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MRAP2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrap21 , 5 melanocortin 2 receptor accessory protein 21, 5 86.18(n)1
    87.8(a)1
      9 (46.76 cM)5
    2449581  NM_001101482.21  NP_001094952.21 
     871443065 
    chicken
    (Gallus gallus)
    Aves MRAP21 melanocortin 2 receptor accessory protein 2 73.17(n)
    75.12(a)
      421836  XM_419857.3  XP_419857.1 
    lizard
    (Anolis carolinensis)
    Reptilia MRAP26
    Uncharacterized protein
    58(a)
    1 ↔ 1
    1(197218554-197267092)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000033301 melanocortin-2 receptor accessory protein 2-like 73.63(n)
    79.1(a)
      100003330  XM_001342887.3  XP_001342923.3 


    ENSEMBL Gene Tree for MRAP2 (if available)
    TreeFam Gene Tree for MRAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1278 SNPs in MRAP2 are shown (see all 1278)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478597151,2
    C--84741425(+) CAATGC/TCCTGA 1 -- us2k10--------
    rs77510731,2
    C,F,H--84741501(+) CTGGAA/GCTGGT 1 -- us2k16Minor allele frequency- G:0.02NS EA WA 532
    rs572236751,2
    C--84741520(+) TTGGGG/AAATGA 1 -- us2k12Minor allele frequency- A:0.10WA 120
    rs1147680841,2
    F--84741530(+) ATTAAT/CAAATC 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1886767131,2
    --84741596(+) AGAAGA/TTACAT 1 -- us2k10--------
    rs1413118621,2
    --84741710(+) ATATCC/TTTTGC 1 -- us2k10--------
    rs119626531,2
    C,H--84741725(+) tttttA/Gatggg 1 -- us2k10--------
    rs1811056351,2
    --84741728(+) TTGATA/GGGGTT 1 -- us2k10--------
    rs1450054761,2
    --84741746(+) TCTTGG/TAAATT 1 -- us2k10--------
    rs77556281,2
    C,F,A--84741890(+) gcacaC/Tataca 1 -- us2k11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for MRAP2 (84743420 - 84800606 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MRAP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5378CNV Loss18451855
    nsv830719CNV Gain17160897
    nsv7938CNV Gain18304495
    nsv886331CNV Gain21882294
    essv14922CNV CNV17122850
    dgv1989e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615410    OMIM disorders: --

    2 diseases for MRAP2:    About MalaCards
    familial glucocorticoid deficiency    


    MRAP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRAP2

    Export disorders for MRAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRAP2 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with MRAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Loss of function of the melanocortin 2 receptor access ory protein 2 is associated with mammalian obesity. (PubMed id 23869016)1 Asai M....Majzoub J.A. (2013)
    5. Melanocortin receptor accessory proteins in adrenal gl and physiology and beyond. (PubMed id 23418361)1 Novoselova T.V....Chan L.F. (2013)
    6. Melanocortin 2 receptor-associated protein (MRAP) and MRAP2 in human adrenocortical tissues: regulation of expression and association with ACTH responsiveness. (PubMed id 22419722)1 Hofland J....de Jong F.H. (2012)
    7. Localisation of the melanocortin-2-receptor and its a ccessory proteins in the developing and adult adrenal gland. (PubMed id 21367968)1 Gorrigan R.J....Chan L.F. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Regulation of G protein-coupled receptor signaling: s pecific dominant-negative effects of melanocortin 2 receptor accessory protein 2. (PubMed id 20371771)1 Sebag J.A. and Hinkle P.M. (2010)
    10. MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. (PubMed id 19329486)1 Chan L.F....Clark A.J. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 112609 HGNC: 21232 AceView: C6orf117 Ensembl:ENSG00000135324 euGenes: HUgn112609
    ECgene: MRAP2 H-InvDB: MRAP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRAP2 gene:
    Search GeneIP for patents involving MRAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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