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MRAP2 Gene

protein-coding   GIFtS: 48
GCID: GC06P084743

Melanocortin 2 Receptor Accessory Protein 2

(Previous name: chromosome 6 open reading frame 117)
(Previous symbol: C6orf117)
  See MRAP2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Melanocortin 2 Receptor Accessory Protein 21 2     Chromosome 6 Open Reading Frame 1171
C6orf1171 2 3 5     bA51G5.22
MC2R Accessory Protein 22 3     Melanocortin-2 Receptor Accessory Protein 22
BMIQ182 5     

External Ids:    HGNC: 212321   Entrez Gene: 1126092   Ensembl: ENSG000001353247   OMIM: 6154105   UniProtKB: Q96G303   

Export aliases for MRAP2 gene to outside databases

Previous GC identifers: GC06P084801 GC06P081973


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MRAP2 Gene:
MRAP2 (melanocortin 2 receptor accessory protein 2) is a protein-coding gene. Diseases associated with MRAP2 include obesity bmiq18, and familial glucocorticoid deficiency. GO annotations related to this gene include type 1 melanocortin receptor binding and type 3 melanocortin receptor binding.

UniProtKB/Swiss-Prot: MRAP2_HUMAN, Q96G30
Function: Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central
role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and
MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with
MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of
other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRAP2 gene promoter:
         USF1   SREBP-1c   Brachyury   SREBP-1b   SREBP-1a   POU2F1   POU2F1b   POU2F1a   USF-1   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRAP2 promoter sequence
   Search Chromatin IP Primers for MRAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.2   Ensembl cytogenetic band:  6q14.2   HGNC cytogenetic band: 6q14.3

MRAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRAP2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P084743:  view genomic region     (about GC identifiers)

Start:
84,743,420 bp from pter      End:
84,800,606 bp from pter
Size:
57,187 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MRAP2_HUMAN, Q96G30 (See protein sequence)
Recommended Name: Melanocortin-2 receptor accessory protein 2  
Size: 205 amino acids; 23548 Da
Subunit: Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP. Interacts with MC1R,
MC2R, MC3R, MC4R and MC5R
Secondary accessions: A8K9M1 Q8IXM9 Q8N2D1

Explore the universe of human proteins at neXtProt for MRAP2: NX_Q96G30

Explore proteomics data for MRAP2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn9
  • Modification sites at PhosphoSitePlus

  • See MRAP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612418.2  
    ENSEMBL proteins: 
     ENSP00000257776  

    MRAP2 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MRAP2

     
    Search eBioscience for Proteins for MRAP2 

     
    antibodies-online proteins for MRAP2 

     
    antibodies-online peptides for MRAP2

    MRAP2 Antibody Products:

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    antibodies-online antibodies for MRAP2 (10 products) 

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    Cloud-Clone Corp. ELISAs for MRAP2
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    antibodies-online kits for MRAP2 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028111 MRAP

    Graphical View of Domain Structure for InterPro Entry Q96G30

    ProtoNet protein and cluster: Q96G30

    UniProtKB/Swiss-Prot: MRAP2_HUMAN, Q96G30
    Similarity: Belongs to the MRAP family


    Find genes that share domains with MRAP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRAP2_HUMAN, Q96G30
    Function: Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central
    role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and
    MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with
    MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of
    other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031780corticotropin hormone receptor binding IPI19329486
    GO:0031781type 3 melanocortin receptor binding IPI19329486
    GO:0031782type 4 melanocortin receptor binding IPI19329486
    GO:0031783type 5 melanocortin receptor binding IPI19329486
    GO:0070996type 1 melanocortin receptor binding IPI19329486
         
    Find genes that share ontologies with MRAP2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MRAP2:
     Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mrap2):
     adipose tissue  behavior/neurological  digestive/alimentary  growth/size/body  homeostasis/metabolism 
     liver/biliary system 

    Find genes that share phenotypes with MRAP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mrap2tm1.1Maj for MRAP2

       genOway: Develop your customized and physiologically relevant rodent model for MRAP2

    miRNA
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    miRTarBase miRNAs that target MRAP2:
    hsa-mir-21-5p (MIRT030877)

    Block miRNA regulation of human, mouse, rat MRAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MRAP2 (see all 10):
    hsa-miR-7-2* hsa-miR-578 hsa-miR-3647-3p hsa-miR-105 hsa-miR-1912 hsa-miR-1305 hsa-miR-7-1* hsa-miR-378*
    SwitchGear 3'UTR luciferase reporter plasmidMRAP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MRAP2

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRAP2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRAP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MRAP2_HUMAN, Q96G30: Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass
    membrane protein. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can
    both localize in the cytoplasmic and extracellular parts, depending on the context (PubMed:20371771)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    plasma membrane4
    cytosol1
    endosome1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA19329486
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane IDA19329486
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with MRAP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRAP2
    Interactions:

        Search GeneGlobe Interaction Network for MRAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for MRAP2 (ENSP000002577764) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MC2RENSP000003338214STRING: ENSP00000333821
    MC3RENSP000002439114STRING: ENSP00000243911
    MC4RENSP000002997664STRING: ENSP00000299766
    MC5RENSP000003180774STRING: ENSP00000318077
    MRAPENSP000003066974STRING: ENSP00000306697
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process ISS--
    GO:0007631feeding behavior ISS--
    GO:0030819positive regulation of cAMP biosynthetic process IDA19329486
    GO:0034394protein localization to cell surface IDA19329486
    GO:0097009energy homeostasis ISS--

    Find genes that share ontologies with MRAP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRAP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MRAP2 gene: 
    NM_138409.2  

    Unigene Cluster for MRAP2:

    Melanocortin 2 receptor accessory protein 2
    Hs.370055  [show with all ESTs]
    Unigene Representative Sequence: NM_138409
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000257776(uc003pkg.4 uc010kbo.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat MRAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MRAP2 (see all 10):
    hsa-miR-7-2* hsa-miR-578 hsa-miR-3647-3p hsa-miR-105 hsa-miR-1912 hsa-miR-1305 hsa-miR-7-1* hsa-miR-378*
    SwitchGear 3'UTR luciferase reporter plasmidMRAP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MRAP2
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    GenScript: all cDNA clones in your preferred vector: MRAP2 (NM_138409)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRAP2
      QuantiTect SYBR Green Assays in human, mouse, rat MRAP2
      QuantiFast Probe-based Assays in human, mouse, rat MRAP2

    Additional mRNA sequence: 

    AJ420596.1 AK090775.1 AK292736.1 AK307078.1 BC010003.2 BC039855.1 

    2 DOTS entries:

    DT.100016423  DT.97785541 

    Selected AceView cDNA sequences (see all 64):

    AK090775 AI694370 AW957353 BF446244 AA947918 AX746611 BU629097 BC010003 
    AA350098 BC039855 BQ287913 NM_138409 BM128672 AA565808 BF221531 CR609200 
    BQ417370 AJ420596 AA418941 BV202145 AA039481 AI500227 BX451752 CK299862 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAAGCTGTT
    MRAP2 Expression
    About this image


    MRAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Adipose (Muscoskeletal System)
             HyStem+BMP4-induced 7SMOO32 cells
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
     
     Spinal Cord (Nervous System)
    MRAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRAP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.370055

    UniProtKB/Swiss-Prot: MRAP2_HUMAN, Q96G30
    Tissue specificity: Expressed in the adrenal gland and brain. Not expressed in other tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MRAP2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrap21 , 5 melanocortin 2 receptor accessory protein 21, 5 86.18(n)1
    87.8(a)1
      9 (46.76 cM)5
    2449581  NM_001101482.21  NP_001094952.21 
     871443065 
    chicken
    (Gallus gallus)
    Aves MRAP21 melanocortin 2 receptor accessory protein 2 73.17(n)
    75.12(a)
      421836  XM_004940405.1  XP_004940462.1 
    lizard
    (Anolis carolinensis)
    Reptilia MRAP26
    melanocortin 2 receptor accessory protein 2
    58(a)
    1 ↔ 1
    1(197218554-197267092)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mrap21 melanocortin 2 receptor accessory protein 2 69.78(n)
    65.8(a)
      100487833  XM_002933917.2  XP_002933963.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mrap2a1 melanocortin 2 receptor accessory protein 2a 60.07(n)
    55.73(a)
      100003330  XM_001342887.4  XP_001342923.4 


    ENSEMBL Gene Tree for MRAP2 (if available)
    TreeFam Gene Tree for MRAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    MRAP2_HUMAN, Q96G30: Genetic variations in MRAP2 define the body mass index quantitative trait locus 18 (BMIQ18)
    [MIM:615457]. Variance in body mass index is a susceptibility factor for obesity


    Selected SNPs for MRAP2 (see all 1281)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478597151,2
    C--84741425(+) CAATGC/TCCTGA 1 -- us2k10--------
    rs77510731,2
    C,F,H--84741501(+) CTGGAA/GCTGGT 1 -- us2k16Minor allele frequency- G:0.02NS EA WA 532
    rs572236751,2
    C--84741520(+) TTGGGG/AAATGA 1 -- us2k12Minor allele frequency- A:0.10WA 120
    rs1147680841,2
    F--84741530(+) ATTAAT/CAAATC 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1886767131,2
    --84741596(+) AGAAGA/TTACAT 1 -- us2k10--------
    rs1413118621,2
    --84741710(+) ATATCC/TTTTGC 1 -- us2k10--------
    rs119626531,2
    C,H--84741725(+) tttttA/Gatggg 1 -- us2k10--------
    rs1811056351,2
    --84741728(+) TTGATA/GGGGTT 1 -- us2k10--------
    rs1450054761,2
    --84741746(+) TCTTGG/TAAATT 1 -- us2k10--------
    rs77556281,2
    C,F,A--84741890(+) gcacaC/Tataca 1 -- us2k11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for MRAP2 (84743420 - 84800606 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MRAP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5378CNV Loss18451855
    nsv830719CNV Gain17160897
    nsv7938CNV Gain18304495
    nsv886331CNV Gain21882294
    essv14922CNV CNV17122850
    dgv1989e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): MRAP2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRAP2
    DNA2.0 Custom Variant and Variant Library Synthesis for MRAP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615410   
    OMIM disorders: 615457  
    UniProtKB/Swiss-Prot: MRAP2_HUMAN, Q96G30
  • Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the
    limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
    Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry

  • 2 diseases for MRAP2:    
    About MalaCards
    obesity bmiq18    familial glucocorticoid deficiency


    Find genes that share disorders with MRAP2           About GenesLikeMe

    Genetic Association Database (GAD): MRAP2

    Export disorders for MRAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRAP2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with MRAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. (PubMed id 23869016)1, 2 Asai M....Majzoub J.A. (Science 2013)
    2. Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2. (PubMed id 20371771)1, 2 Sebag J.A. and Hinkle P.M. (Sci Signal 2010)
    3. MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. (PubMed id 19329486)1, 2 Chan L.F....Clark A.J. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. Melanocortin receptor accessory proteins in adrenal gland physiology and beyond. (PubMed id 23418361)1 Novoselova T.V....Chan L.F. (J. Endocrinol. 2013)
    8. Melanocortin 2 receptor-associated protein (MRAP) and MRAP2 in human adrenocortical tissues: regulation of expression and association with ACTH responsiveness. (PubMed id 22419722)1 Hofland J....de Jong F.H. (J. Clin. Endocrinol. Metab. 2012)
    9. Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland. (PubMed id 21367968)1 Gorrigan R.J....Chan L.F. (J. Mol. Endocrinol. 2011)
    10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 112609 HGNC: 21232 AceView: C6orf117 Ensembl:ENSG00000135324 euGenes: HUgn112609
    ECgene: MRAP2 H-InvDB: MRAP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRAP2 gene:
    Search GeneIP for patents involving MRAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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