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Aliases for MRAP2 Gene

Aliases for MRAP2 Gene

  • Melanocortin 2 Receptor Accessory Protein 2 2 3
  • C6orf117 3 4 6
  • MC2R Accessory Protein 2 3 4
  • BMIQ18 3 6
  • Melanocortin-2 Receptor Accessory Protein 2 3
  • Chromosome 6 Open Reading Frame 117 2
  • BA51G5.2 3

External Ids for MRAP2 Gene

Previous HGNC Symbols for MRAP2 Gene

  • C6orf117

Previous GeneCards Identifiers for MRAP2 Gene

  • GC06P084801
  • GC06P081973
  • GC06P084743

Summaries for MRAP2 Gene

GeneCards Summary for MRAP2 Gene

MRAP2 (Melanocortin 2 Receptor Accessory Protein 2) is a Protein Coding gene. Diseases associated with MRAP2 include obesity bmiq18 and obesity due to melanocortin 4 receptor deficiency. GO annotations related to this gene include type 3 melanocortin receptor binding and type 1 melanocortin receptor binding.

UniProtKB/Swiss-Prot for MRAP2 Gene

  • Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRAP2 Gene

Genomics for MRAP2 Gene

Regulatory Elements for MRAP2 Gene

Genomic Location for MRAP2 Gene

Start:
84,023,027 bp from pter
End:
84,090,887 bp from pter
Size:
67,861 bases
Orientation:
Plus strand

Genomic View for MRAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRAP2 Gene

Proteins for MRAP2 Gene

  • Protein details for MRAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G30-MRAP2_HUMAN
    Recommended name:
    Melanocortin-2 receptor accessory protein 2
    Protein Accession:
    Q96G30
    Secondary Accessions:
    • A8K9M1
    • Q8IXM9
    • Q8N2D1

    Protein attributes for MRAP2 Gene

    Size:
    205 amino acids
    Molecular mass:
    23548 Da
    Quaternary structure:
    • Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R.

neXtProt entry for MRAP2 Gene

Proteomics data for MRAP2 Gene at MOPED

Post-translational modifications for MRAP2 Gene

  • Glycosylation at Asn9
  • Modification sites at PhosphoSitePlus

Other Protein References for MRAP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRAP2 Gene

Domains for MRAP2 Gene

Protein Domains for MRAP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96G30

UniProtKB/Swiss-Prot:

MRAP2_HUMAN :
  • Q96G30
Family:
  • Belongs to the MRAP family.
genes like me logo Genes that share domains with MRAP2: view

No data available for Gene Families for MRAP2 Gene

Function for MRAP2 Gene

Molecular function for MRAP2 Gene

UniProtKB/Swiss-Prot Function: Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.

Gene Ontology (GO) - Molecular Function for MRAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19329486
GO:0031780 corticotropin hormone receptor binding IPI 19329486
GO:0031781 type 3 melanocortin receptor binding IPI 19329486
GO:0031782 type 4 melanocortin receptor binding IPI 19329486
GO:0031783 type 5 melanocortin receptor binding IPI 19329486
genes like me logo Genes that share ontologies with MRAP2: view
genes like me logo Genes that share phenotypes with MRAP2: view

Animal Models for MRAP2 Gene

MGI Knock Outs for MRAP2:

miRNA for MRAP2 Gene

miRTarBase miRNAs that target MRAP2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MRAP2 Gene

Localization for MRAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRAP2 Gene

Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context. {ECO:0000269 PubMed:20371771}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRAP2 Gene COMPARTMENTS Subcellular localization image for MRAP2 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 4
cytosol 1
endosome 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 19329486
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IDA 19329486
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MRAP2: view

Pathways for MRAP2 Gene

SuperPathways for MRAP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process ISS --
GO:0007631 feeding behavior ISS --
GO:0030819 positive regulation of cAMP biosynthetic process IDA 19329486
GO:0034394 protein localization to cell surface IDA 19329486
GO:0097009 energy homeostasis ISS --
genes like me logo Genes that share ontologies with MRAP2: view

No data available for Pathways by source for MRAP2 Gene

Transcripts for MRAP2 Gene

Unigene Clusters for MRAP2 Gene

Melanocortin 2 receptor accessory protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRAP2 Gene

No ASD Table

Relevant External Links for MRAP2 Gene

GeneLoc Exon Structure for
MRAP2
ECgene alternative splicing isoforms for
MRAP2

Expression for MRAP2 Gene

mRNA expression in normal human tissues for MRAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MRAP2 Gene

This gene is overexpressed in Artery - Aorta (14.1) and Artery - Tibial (5.1).

SOURCE GeneReport for Unigene cluster for MRAP2 Gene Hs.370055

mRNA Expression by UniProt/SwissProt for MRAP2 Gene

Q96G30-MRAP2_HUMAN
Tissue specificity: Expressed in the adrenal gland and brain. Not expressed in other tissues.
genes like me logo Genes that share expressions with MRAP2: view

No data available for Protein expression for MRAP2 Gene

Orthologs for MRAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRAP2 35
  • 99.19 (n)
  • 99.51 (a)
MRAP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRAP2 35
  • 90.08 (n)
  • 91.22 (a)
MRAP2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRAP2 35
  • 90.57 (n)
  • 93.66 (a)
MRAP2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrap2 35
  • 86.18 (n)
  • 87.8 (a)
Mrap2 16
Mrap2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRAP2 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRAP2 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrap2 35
  • 86.83 (n)
  • 89.27 (a)
chicken
(Gallus gallus)
Aves MRAP2 35
  • 73.17 (n)
  • 75.12 (a)
MRAP2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRAP2 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrap2 35
  • 69.78 (n)
  • 65.8 (a)
zebrafish
(Danio rerio)
Actinopterygii mrap2a 35
  • 60.07 (n)
  • 55.73 (a)
mrap2a 36
  • 50 (a)
OneToOne
Species with no ortholog for MRAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRAP2 Gene

ENSEMBL:
Gene Tree for MRAP2 (if available)
TreeFam:
Gene Tree for MRAP2 (if available)

Paralogs for MRAP2 Gene

No data available for Paralogs for MRAP2 Gene

Variants for MRAP2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MRAP2 Gene

Q96G30-MRAP2_HUMAN
Genetic variations in MRAP2 define the body mass index quantitative trait locus 18 (BMIQ18) [MIM:615457]. Variance in body mass index is a susceptibility factor for obesity

Sequence variations from dbSNP and Humsavar for MRAP2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3218 -- 84,090,774(-) TGTGT(A/G)CGCAA utr-variant-3-prime
rs3219 -- 84,090,659(-) GTGGG(A/G)AATTT utr-variant-3-prime
rs8348 -- 84,090,773(-) GTGTG(C/T)GCAAA utr-variant-3-prime
rs981310 -- 84,039,600(+) TGCTC(A/C/G)TGTTT intron-variant
rs986469 -- 84,021,031(+) TTAAT(C/T)GGTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRAP2 Gene

Variant ID Type Subtype PubMed ID
nsv830719 CNV Gain 17160897
nsv886331 CNV Gain 21882294
dgv1989e1 CNV Complex 17122850
essv14922 CNV CNV 17122850
nsv7938 CNV Gain 18304495
nsv5378 CNV Loss 18451855

Relevant External Links for MRAP2 Gene

HapMap Linkage Disequilibrium report
MRAP2
Human Gene Mutation Database (HGMD)
MRAP2

Disorders for MRAP2 Gene

(1) OMIM Diseases for MRAP2 Gene (615410)

UniProtKB/Swiss-Prot

MRAP2_HUMAN
  • Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269 PubMed:23869016}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Relevant External Links for MRAP2

Genetic Association Database (GAD)
MRAP2
genes like me logo Genes that share disorders with MRAP2: view

Publications for MRAP2 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. (PMID: 19329486) Chan L.F. … Clark A.J. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4
  5. Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2. (PMID: 20371771) Sebag J.A. … Hinkle P.M. (Sci Signal 2010) 3 4

Products for MRAP2 Gene

Sources for MRAP2 Gene

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