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MRAP Gene

protein-coding   GIFtS: 50
GCID: GC21P033664

Melanocortin 2 Receptor Accessory Protein

(Previous name: chromosome 21 open reading frame 61)
(Previous symbol: C21orf61)
  See MRAP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Melanocortin 2 Receptor Accessory Protein1 2     B272 3
C21orf611 2 3 5     FGD22 5
FALP2 3 5     GCCD22 5
Fat Cell-Specific Low Molecular Weight Protein2 3     Chromosome 21 Open Reading Frame 611
Fat Tissue-Specific Low MW Protein2 3     Melanocortin-2 Receptor Accessory Protein2

External Ids:    HGNC: 13041   Entrez Gene: 562462   Ensembl: ENSG000001702627   OMIM: 6091965   UniProtKB: Q8TCY53   
ORGUL members:         

Export aliases for MRAP gene to outside databases

Previous GC identifers: GC21P032586 GC21P019073


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRAP Gene:
This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and
function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of
other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency
type 2. Alternatively spliced transcript variants have been described. (provided by RefSeq, Dec 2009)

GeneCards Summary for MRAP Gene:
MRAP (melanocortin 2 receptor accessory protein) is a protein-coding gene. Diseases associated with MRAP include familial glucocorticoid deficiency, and iritis. GO annotations related to this gene include type 1 melanocortin receptor binding and type 3 melanocortin receptor binding.

UniProtKB/Swiss-Prot: MRAP_HUMAN, Q8TCY5
Function: Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing
ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for
MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May
be involved in the intracellular trafficking pathways in adipocyte cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRAP gene promoter:
         E2F-3a   E2F-4   STAT1   E2F-5   E2F-2   C/EBPalpha   E2F-1   E2F   HSF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRAP promoter sequence
   Search Chromatin IP Primers for MRAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.1   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.1

MRAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRAP gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P033664:  view genomic region     (about GC identifiers)

Start:
33,664,124 bp from pter      End:
33,687,095 bp from pter
Size:
22,972 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MRAP_HUMAN, Q8TCY5 (See protein sequence)
Recommended Name: Melanocortin-2 receptor accessory protein  
Size: 172 amino acids; 19136 Da
Subunit: Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP2. Interacts with
MC1R, MC2R, MC3R, MC4R and MC5R
Secondary accessions: Q5EBR3 Q8TDB7 Q8WXC1 Q8WXC2
Alternative splicing: 4 isoforms:  Q8TCY5-4   Q8TCY5-1   Q8TCY5-2   Q8TCY5-3   

Explore the universe of human proteins at neXtProt for MRAP: NX_Q8TCY5

Explore proteomics data for MRAP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MRAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_848932.1  NP_996781.1  NP_001272323.1  

    ENSEMBL proteins: 
     ENSP00000382684   ENSP00000306697   ENSP00000343661   ENSP00000382686  

    MRAP Human Recombinant Protein Products:

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    Novus Biologicals MRAP Proteins
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    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for MRAP

     
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    MRAP Assay Products:

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    Search eBioscience for ELISAs for MRAP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028111 MRAP

    Graphical View of Domain Structure for InterPro Entry Q8TCY5

    ProtoNet protein and cluster: Q8TCY5

    UniProtKB/Swiss-Prot: MRAP_HUMAN, Q8TCY5
    Similarity: Belongs to the MRAP family


    Find genes that share domains with MRAP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRAP_HUMAN, Q8TCY5
    Function: Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing
    ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for
    MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May
    be involved in the intracellular trafficking pathways in adipocyte cells

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031780corticotropin hormone receptor binding IPI19329486
    GO:0031781type 3 melanocortin receptor binding IPI19329486
    GO:0031782type 4 melanocortin receptor binding IPI19329486
    GO:0031783type 5 melanocortin receptor binding IPI19329486
    GO:0070996type 1 melanocortin receptor binding IPI19329486
         
    Find genes that share ontologies with MRAP           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRAP
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRAP
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    miRNA
    Products:
        
    miRTarBase miRNAs that target MRAP:
    hsa-mir-335-5p (MIRT017089)

    Block miRNA regulation of human, mouse, rat MRAP using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MRAP
    SwitchGear 3'UTR luciferase reporter plasmidMRAP 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat MRAP

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): MRAP (NM_178817)
    Sino Biological Human cDNA Clone for MRAP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRAP

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRAP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MRAP_HUMAN, Q8TCY5: Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass
    membrane protein. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can
    both localize in the cytoplasmic and extracellular parts, depending on the context (PubMed:20371771). Upon
    insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    cytoskeleton2
    cytosol1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA19329486
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane IDA19329486
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with MRAP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRAP
    Interactions:

        GeneGlobe Interaction Network for MRAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for MRAP (Q8TCY53 ENSP000003066974) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MGRN1O602913, ENSP000002623704I2D: score=1 STRING: ENSP00000262370
    MC2RQ017183, ENSP000003338214I2D: score=2 STRING: ENSP00000333821
    ENSG00000258947ENSP000003202954STRING: ENSP00000320295
    MC3RENSP000002439114STRING: ENSP00000243911
    MC4RENSP000002997664STRING: ENSP00000299766
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030819positive regulation of cAMP biosynthetic process IDA19329486
    GO:0034394protein localization to cell surface IDA19329486
    GO:0050873brown fat cell differentiation IEA--

    Find genes that share ontologies with MRAP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRAP

    1 Novoseek inferred chemical compound relationship for MRAP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acth 84.7 33 17456795 (3), 18426811 (2), 20371771 (2), 18981183 (2) (see all 16)



    Find genes that share compounds with MRAP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MRAP gene (3 alternative transcripts): 
    NM_178817.3  NM_206898.1  NM_001285394.1  

    Unigene Cluster for MRAP:

    Melanocortin 2 receptor accessory protein
    Hs.584940  [show with all ESTs]
    Unigene Representative Sequence: NM_178817
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399784(uc002ypj.3) ENST00000497833(uc011ado.2) ENST00000303645(uc002ypl.3)
    ENST00000339944 ENST00000399786(uc002ypk.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MRAP using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MRAP
    SwitchGear 3'UTR luciferase reporter plasmidMRAP 3' UTR sequence
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRAP
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MRAP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRAP
      QuantiTect SYBR Green Assays in human, mouse, rat MRAP
      QuantiFast Probe-based Assays in human, mouse, rat MRAP

    Additional mRNA sequence: 

    AF454915.1 AF454916.1 AF483549.1 AY079152.1 BC062721.1 

    5 DOTS entries:

    DT.92042754  DT.100742365  DT.121138523  DT.100682870  DT.212590 

    14 AceView cDNA sequences:

    AF483549 AI022711 AY079152 AW449617 BC062721 AW105180 AI742243 CD104898 
    AF454916 AF454915 CB986525 NM_178817 BX281553 NM_206898 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCAGAAAG
    MRAP Expression
    About this image


    MRAP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Granulosa Cells Primary Follicle
             Oviduct
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Lung (Respiratory System)
             Trachea
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    MRAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRAP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.584940

    UniProtKB/Swiss-Prot: MRAP_HUMAN, Q8TCY5
    Tissue specificity: Expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary and fat. Expressed in
    adipose tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for MRAP gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrap1 , 5 melanocortin 2 receptor accessory protein1, 5 79.77(n)1
    70.09(a)1
      16 (51.90 cM)5
    770371  NM_029844.31  NP_084120.11 
     907383245 


    ENSEMBL Gene Tree for MRAP (if available)
    TreeFam Gene Tree for MRAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MRAP (see all 652)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs803582311,2
    Cpathogenic124214880(+) GACATA/GGCCAA 4 I M mis10--------
    rs2010001271,2
    C--24205785(+) ATATAC/TTCCAT 2 -- us2k10--------
    rs1407060601,2
    C--24205871(+) ATATAG/TTCCAC 2 -- us2k10--------
    rs1807661981,2
    --24205886(+) ATATAG/TTCCAC 2 -- us2k10--------
    rs2016991471,2
    C--24205892(+) GTCCA-/ATTATAT 2 -- us2k10--------
    rs1850145121,2
    --24205903(+) ATATAG/TTCCAC 2 -- us2k10--------
    rs1898190471,2
    --24205951(+) TATAGG/TCCACA 2 -- us2k10--------
    rs347713221,2
    C,F--24205972(+) CCACAC/TATATA 2 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1998980421,2
    C--24205986(+) TCCAC-/ATATATA 2 -- us2k10--------
    rs39891901,2
    C--24205999(+) atata-/TAgtcca 2 -- us2k11Minor allele frequency- TA:0.00NA 2

    HapMap Linkage Disequilibrium report for MRAP (33664124 - 33687095 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MRAP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv187437CNV Insertion16902084
    esv1730259CNV Insertion17803354
    esv1007564CNV Insertion20482838
    nsv510795CNV Loss20534489
    esv23692CNV Loss19812545
    nsv834084CNV Gain17160897

    Human Gene Mutation Database (HGMD): MRAP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRAP
    DNA2.0 Custom Variant and Variant Library Synthesis for MRAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609196   
    OMIM disorders: 607398  
    UniProtKB/Swiss-Prot: MRAP_HUMAN, Q8TCY5
  • Glucocorticoid deficiency 2 (GCCD2) [MIM:607398]: A rare, potentially lethal, autosomal recessive
    disorder characterized by resistance to ACTH action on the adrenal cortex, adrenal insufficiency and an inability
    of the adrenal cortex to produce cortisol. It usually presents in the neonatal period or in early childhood with
    episodes of hypoglycemia and other symptoms related to cortisol deficiency, including failure to thrive,
    recurrent illnesses or infections, convulsions, and shock. In a small number of patients hypoglycemia can be
    sufficiently severe and persistent that it leads to serious long-term neurological damage or death. The diagnosis
    is readily confirmed with a low plasma cortisol measurement in the presence of an elevated ACTH level, and normal
    aldosterone and plasma renin measurements. Note=The disease is caused by mutations affecting the gene represented
    in this entry

  • 6 diseases for MRAP:    
    About MalaCards
    familial glucocorticoid deficiency    iritis    glucocorticoid deficiency 2    sorsby fundus dystrophy
    glucocorticoid deficiency, due to acth unresponsiveness    addison's disease

    9 diseases from the University of Copenhagen DISEASES database for MRAP:
    Ankylosing spondylitis     Arthropathy     Arthritis     Uveitis
    Psoriatic arthritis     Psoriasis     Iritis     Connective tissue disease
    Inflammatory bowel disease

    Find genes that share disorders with MRAP           About GenesLikeMe

    Genetic Association Database (GAD): MRAP
    Human Genome Epidemiology (HuGE) Navigator: MRAP (23 documents)

    Export disorders for MRAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRAP gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with MRAP)
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    1. Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2. (PubMed id 15654338)1, 2, 3, 9 Metherell L.A.... Clark A.J.L. (Nat. Genet. 2005)
    2. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PubMed id 12036298)1, 2, 3 Gardiner K.... Davisson M. (Genomics 2002)
    3. Isolated Addison's disease is unlikely to be caused by mutations in MC2R, MRAP or STAR, three genes responsible for familial glucocorticoid deficiency. (PubMed id 19903795)1, 4, 9 Dias R.P....Clark A.J. (Eur. J. Endocrinol. 2010)
    4. Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2. (PubMed id 19558534)1, 4, 9 Chung T.T....Clark A.J. (Clin. Endocrinol. (Oxf) 2010)
    5. MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. (PubMed id 19329486)1, 2 Chan L.F....Clark A.J. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells. (PubMed id 12054497)1, 2 Xu A....Cooper G.J.S. (Biochem. Biophys. Res. Commun. 2002)
    8. Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers. (PubMed id 18077336)1, 9 Sebag J.A. and Hinkle P.M. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    9. Regions of melanocortin 2 (MC2) receptor accessory protein necessary for dual topology and MC2 receptor trafficking and signaling. (PubMed id 18981183)1, 9 Sebag J.A. and Hinkle P.M. (J. Biol. Chem. 2009)
    10. Distinct melanocortin 2 receptor accessory protein domains are required for melanocortin 2 receptor interaction and promotion of receptor trafficking. (PubMed id 18818285)1, 9 Webb T.R....Clark A.J. (Endocrinology 2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56246 HGNC: 1304 AceView: C21orf61 Ensembl:ENSG00000170262 euGenes: HUgn56246
    ECgene: MRAP H-InvDB: MRAP

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRAP Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=MRAP[genesymbol]

    (Patent information from GeneIP,
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    Patent Information for MRAP gene:
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