Aliases for MRAP Gene
External Ids for MRAP Gene
Previous HGNC Symbols for MRAP Gene
Previous GeneCards Identifiers for MRAP Gene
This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009]
GeneCards Summary for MRAP Gene
MRAP (Melanocortin 2 Receptor Accessory Protein) is a Protein Coding gene. Diseases associated with MRAP include glucocorticoid deficiency 2 and familial glucocorticoid deficiency. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include type 3 melanocortin receptor binding and type 1 melanocortin receptor binding.
UniProtKB/Swiss-Prot for MRAP Gene
Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.