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Aliases for MR1 Gene

Aliases for MR1 Gene

  • Major Histocompatibility Complex, Class I-Related 2 3
  • Major Histocompatibility Complex, Class I-Like Sequence 2 3
  • Class I Histocompatibility Antigen-Like Protein 3 4
  • MHC Class I-Related Gene Protein 3 4
  • HLALS 3 6
  • Major Histocompatibility Complex Class I-Related Gene Protein 3
  • MHC Class-I Related-Gene Protein 3
  • MHC Class I-Like Antigen MR-1 3

External Ids for MR1 Gene

Previous HGNC Symbols for MR1 Gene

  • HLALS

Previous GeneCards Identifiers for MR1 Gene

  • GC01P176431
  • GC01P177523
  • GC01P178242
  • GC01P177734
  • GC01P179269
  • GC01P152233

Summaries for MR1 Gene

GeneCards Summary for MR1 Gene

MR1 (Major Histocompatibility Complex, Class I-Related) is a Protein Coding gene. Diseases associated with MR1 include paroxysmal nonkinesigenic dyskinesia and microscopic colitis. GO annotations related to this gene include antigen binding and MHC class I receptor activity. An important paralog of this gene is HLA-B.

UniProtKB/Swiss-Prot for MR1 Gene

  • Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.

Gene Wiki entry for MR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MR1 Gene

Genomics for MR1 Gene

Regulatory Elements for MR1 Gene

Genomic Location for MR1 Gene

Start:
181,033,379 bp from pter
End:
181,061,938 bp from pter
Size:
28,560 bases
Orientation:
Plus strand

Genomic View for MR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MR1 Gene

Proteins for MR1 Gene

  • Protein details for MR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q95460-HMR1_HUMAN
    Recommended name:
    Major histocompatibility complex class I-related gene protein
    Protein Accession:
    Q95460
    Secondary Accessions:
    • A8K2V9
    • B4E3B1
    • O97985
    • O97986
    • Q53GM1
    • Q95HB8
    • Q9MY23
    • Q9NPL2
    • Q9TQB3
    • Q9TQB9
    • Q9TQK3

    Protein attributes for MR1 Gene

    Size:
    341 amino acids
    Molecular mass:
    39366 Da
    Quaternary structure:
    • Heterodimerizes with B2M, this interaction is required for surface expression. Associated with the peptide-loading complex, TAPBP, CALR and PDIA3. Isoform 3/MR1B homodimerizes and doesnt associates with B2M nor proteins of the peptide-loading complex.
    Miscellaneous:
    • MR1 is detected in an open versus folded conformation. Only the folded MR1 conformer activates MAIT cells
    SequenceCaution:
    • Sequence=AAD01443.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MR1 Gene

    Alternative splice isoforms for MR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MR1 Gene

Proteomics data for MR1 Gene at MOPED

Post-translational modifications for MR1 Gene

No data available for DME Specific Peptides for MR1 Gene

Domains for MR1 Gene

Gene Families for MR1 Gene

HGNC:
  • C1SET :Immunoglobulin superfamily / C1-set domain containing

Graphical View of Domain Structure for InterPro Entry

Q95460

UniProtKB/Swiss-Prot:

HMR1_HUMAN :
  • Q95460
Domain:
  • The alpha-3 region and to a lesser extent the transmembrane and cytosolic domains regulate surface expression. The alpha-3 region mediates interaction with B2M (PubMed:23051753).
  • The ligand-binding groove is ideally suited to present small organic compounds that can originate from vitamins rather than antigenic peptides.
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with MR1: view

Function for MR1 Gene

Molecular function for MR1 Gene

UniProtKB/Swiss-Prot Function: Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.

Gene Ontology (GO) - Molecular Function for MR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0032393 MHC class I receptor activity TAS 7624800
GO:0042605 peptide antigen binding IEA --
genes like me logo Genes that share ontologies with MR1: view
genes like me logo Genes that share phenotypes with MR1: view

Animal Models for MR1 Gene

MGI Knock Outs for MR1:

miRNA for MR1 Gene

miRTarBase miRNAs that target MR1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MR1 Gene

Localization for MR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MR1 Gene

Cell membrane; Single-pass membrane protein; Extracellular side. Endoplasmic reticulum.
Isoform 4: Secreted.
Isoform 3: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane. Note=The larger proportion remains in the ER in an immature state. The subset that reach cell surface does it through a B2M-independent pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MR1 Gene COMPARTMENTS Subcellular localization image for MR1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for MR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005783 endoplasmic reticulum IDA 21190736
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MR1: view

Pathways for MR1 Gene

SuperPathways for MR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity IEA --
GO:0002367 cytokine production involved in immune response IEA --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I IEA --
GO:0006955 immune response TAS 7624800
GO:0007165 signal transduction TAS 7624800
genes like me logo Genes that share ontologies with MR1: view

No data available for Pathways by source for MR1 Gene

Compounds for MR1 Gene

(1) Drugbank Compounds for MR1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Antithymocyte globulin
  • rabbit ATG
target antagonist

(2) Novoseek inferred chemical compound relationships for MR1 Gene

Compound -log(P) Hits PubMed IDs
iron 30.3 1
cysteine 16 2
genes like me logo Genes that share compounds with MR1: view

Transcripts for MR1 Gene

Unigene Clusters for MR1 Gene

Major histocompatibility complex, class I-related:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MR1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: -
SP3:

Relevant External Links for MR1 Gene

GeneLoc Exon Structure for
MR1
ECgene alternative splicing isoforms for
MR1

Expression for MR1 Gene

mRNA expression in normal human tissues for MR1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MR1 Gene

SOURCE GeneReport for Unigene cluster for MR1 Gene Hs.13500

mRNA Expression by UniProt/SwissProt for MR1 Gene

Q95460-HMR1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with MR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MR1 Gene

Orthologs for MR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MR1 35
  • 98.82 (n)
  • 99.21 (a)
MR1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MR1 35
  • 84.28 (n)
  • 78.51 (a)
MR1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mr1 35
  • 82.03 (n)
  • 77.71 (a)
Mr1 16
Mr1 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MR1 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Mr1 35
  • 81.64 (n)
  • 76.65 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 39 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
BF1 36
  • 35 (a)
ManyToMany
BFIV21 36
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
Species with no ortholog for MR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MR1 Gene

ENSEMBL:
Gene Tree for MR1 (if available)
TreeFam:
Gene Tree for MR1 (if available)

Paralogs for MR1 Gene

Paralogs for MR1 Gene

Pseudogenes.org Pseudogenes for MR1 Gene

genes like me logo Genes that share paralogs with MR1: view

Variants for MR1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MR1 Gene

Q95460-HMR1_HUMAN
Several individuals from different ethnic background were analyzed for polymorphism. MR1 was identical in all individuals analyzed, except one. MR1 is not polymorphic

Sequence variations from dbSNP and Humsavar for MR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1052632 -- 181,051,094(+) GTATG(A/G)TCTTG intron-variant
rs1411479 -- 181,037,794(-) TGTCT(C/T)ATGTT intron-variant
rs2183424 -- 181,036,798(-) AAGTG(C/T)CTGTT intron-variant
rs2236410 Likely benign, - 181,049,100(-) CCCCA(C/T)GGATG reference, missense, intron-variant
rs2236411 -- 181,049,044(-) GGAAA(C/G)GAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MR1 Gene

Variant ID Type Subtype PubMed ID
esv2719940 CNV Deletion 23290073
esv993520 CNV Deletion 20482838
nsv819813 CNV Loss 19587683

Relevant External Links for MR1 Gene

HapMap Linkage Disequilibrium report
MR1
Human Gene Mutation Database (HGMD)
MR1

Disorders for MR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for MR1 Gene including...

Search for MR1 Gene in MalaCards »

(2) Novoseek inferred disease relationships for MR1 Gene

Disease -log(P) Hits PubMed IDs
hereditary hemochromatosis 67.6 1
hemochromatosis 54.8 1

Relevant External Links for MR1

Genetic Association Database (GAD)
MR1
Human Genome Epidemiology (HuGE) Navigator
MR1
genes like me logo Genes that share disorders with MR1: view

No data available for UniProtKB/Swiss-Prot for MR1 Gene

Publications for MR1 Gene

  1. A gene outside the human MHC related to classical HLA class I genes. (PMID: 7624800) Hashimoto K. … Kurosawa Y. (Science 1995) 2 3 4 23
  2. Expanded genomic organization of conserved mammalian MHC class I- related genes, human MR1 and its murine ortholog. (PMID: 9784382) Yamaguchi H. … Hashimoto K. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  3. Biochemical features of the MHC-related protein 1 consistent with an immunological function. (PMID: 12794138) Miley M.J. … Lybarger L. (J. Immunol. 2003) 3 4 23
  4. Novel MHC class I-related molecule MR1 affects MHC class I expression in 293T cells. (PMID: 18068122) Aldemir H. (Biochem. Biophys. Res. Commun. 2008) 3 4 23
  5. Genomics, isoforms, expression, and phylogeny of the MHC class I- related MR1 gene. (PMID: 9780177) Riegert P. … Bahram S. (J. Immunol. 1998) 3 4 23

Products for MR1 Gene

Sources for MR1 Gene

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