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Aliases for MPZL3 Gene

Aliases for MPZL3 Gene

  • Myelin Protein Zero Like 3 2 3
  • Myelin Protein Zero-Like 3 5

External Ids for MPZL3 Gene

Previous GeneCards Identifiers for MPZL3 Gene

  • GC11M117604
  • GC11M118097
  • GC11M114033

Summaries for MPZL3 Gene

GeneCards Summary for MPZL3 Gene

MPZL3 (Myelin Protein Zero Like 3) is a Protein Coding gene. An important paralog of this gene is MPZL1.

UniProtKB/Swiss-Prot for MPZL3 Gene

  • Mediates homophilic cell-cell adhesion.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPZL3 Gene

Genomics for MPZL3 Gene

Regulatory Elements for MPZL3 Gene

Enhancers for MPZL3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MPZL3 on UCSC Golden Path with GeneCards custom track

Promoters for MPZL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MPZL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MPZL3 Gene

118,226,690 bp from pter
118,252,368 bp from pter
25,679 bases
Minus strand

Genomic View for MPZL3 Gene

Genes around MPZL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPZL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPZL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPZL3 Gene

Proteins for MPZL3 Gene

  • Protein details for MPZL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myelin protein zero-like protein 3
    Protein Accession:
    Secondary Accessions:
    • A8K025
    • B4DLD5
    • B4E2I8

    Protein attributes for MPZL3 Gene

    235 amino acids
    Molecular mass:
    25989 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MPZL3 Gene


neXtProt entry for MPZL3 Gene

Proteomics data for MPZL3 Gene at MOPED

Post-translational modifications for MPZL3 Gene

  • Glycosylation at Asn 123
  • Modification sites at PhosphoSitePlus

Other Protein References for MPZL3 Gene

No data available for DME Specific Peptides for MPZL3 Gene

Domains & Families for MPZL3 Gene

Gene Families for MPZL3 Gene

Suggested Antigen Peptide Sequences for MPZL3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the myelin P0 protein family.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the myelin P0 protein family.
genes like me logo Genes that share domains with MPZL3: view

Function for MPZL3 Gene

Molecular function for MPZL3 Gene

UniProtKB/Swiss-Prot Function:
Mediates homophilic cell-cell adhesion.
genes like me logo Genes that share phenotypes with MPZL3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MPZL3

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPZL3 Gene

Localization for MPZL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPZL3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for MPZL3 Gene COMPARTMENTS Subcellular localization image for MPZL3 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for MPZL3 Gene

Pathways & Interactions for MPZL3 Gene

SuperPathways for MPZL3 Gene

No Data Available

Interacting Proteins for MPZL3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000278949 Q6UWV2-MPZL3_HUMAN for MPZL3 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for MPZL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042633 hair cycle IEA --
genes like me logo Genes that share ontologies with MPZL3: view

No data available for Pathways by source and SIGNOR curated interactions for MPZL3 Gene

Drugs & Compounds for MPZL3 Gene

No Compound Related Data Available

Transcripts for MPZL3 Gene

Unigene Clusters for MPZL3 Gene

Myelin protein zero-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MPZL3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP2: - - -

Relevant External Links for MPZL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPZL3 Gene

mRNA expression in normal human tissues for MPZL3 Gene

mRNA differential expression in normal tissues according to GTEx for MPZL3 Gene

This gene is overexpressed in Whole Blood (x9.8), Esophagus - Mucosa (x5.9), Skin - Not Sun Exposed (Suprapubic) (x5.5), and Skin - Sun Exposed (Lower leg) (x5.4).

Protein differential expression in normal tissues from HIPED for MPZL3 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MPZL3 Gene

SOURCE GeneReport for Unigene cluster for MPZL3 Gene Hs.15396

genes like me logo Genes that share expression patterns with MPZL3: view

Protein tissue co-expression partners for MPZL3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MPZL3 Gene

Orthologs for MPZL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MPZL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MPZL3 35
  • 87.46 (n)
  • 88.46 (a)
MPZL3 36
  • 88 (a)
(Canis familiaris)
Mammalia MPZL3 35
  • 89.36 (n)
  • 89.79 (a)
MPZL3 36
  • 90 (a)
(Mus musculus)
Mammalia Mpzl3 35
  • 85.07 (n)
  • 88.26 (a)
Mpzl3 16
Mpzl3 36
  • 87 (a)
(Pan troglodytes)
Mammalia MPZL3 35
  • 99.15 (n)
  • 99.15 (a)
MPZL3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mpzl3 35
  • 84.54 (n)
  • 88.51 (a)
(Monodelphis domestica)
Mammalia MPZL3 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia MPZL3 36
  • 77 (a)
(Gallus gallus)
Aves MPZL3 35
  • 62.62 (n)
  • 56.07 (a)
MPZL3 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mpzl3 35
  • 55.61 (n)
  • 46.92 (a)
(Danio rerio)
Actinopterygii mpzl3 36
  • 29 (a)
Species with no ortholog for MPZL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPZL3 Gene

Gene Tree for MPZL3 (if available)
Gene Tree for MPZL3 (if available)

Paralogs for MPZL3 Gene

Paralogs for MPZL3 Gene

(4) SIMAP similar genes for MPZL3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MPZL3: view

Variants for MPZL3 Gene

Sequence variations from dbSNP and Humsavar for MPZL3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs17121966 - 118,235,578(+) AAGCA(C/T)GGTGC intron-variant, nc-transcript-variant, reference, missense
rs7105729 - 118,229,919(+) CTGAA(A/T)CCTGG nc-transcript-variant, reference, missense
rs36102742 - 118,235,538(+) AGGGC(A/C)CAAAG intron-variant, nc-transcript-variant, reference, missense
rs34507994 - 118,235,527(+) CACCA(A/C/T)GGCTG intron-variant, nc-transcript-variant, reference, missense
rs869638 -- 118,229,696(+) TGAGA(C/G)TTCCT intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MPZL3 Gene

Variant ID Type Subtype PubMed ID
nsv511 CNV Insertion 18451855

Variation tolerance for MPZL3 Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.18; 69.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MPZL3 Gene

Disorders for MPZL3 Gene

Relevant External Links for MPZL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MPZL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPZL3 Gene

Publications for MPZL3 Gene

  1. Mutation in Mpzl3, a novel [corrected] gene encoding a predicted [corrected] adhesion protein, in the rough coat (rc) mice with severe skin and hair abnormalities. (PMID: 17273165) Cao T. … Csiszar K. (J. Invest. Dermatol. 2007) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PMID: 23400010) Del-Aguila J.L. … Boerwinkle E. (Pharmacogenomics J. 2013) 3
  4. A secreted protein microarray platform for extracellular protein interaction discovery. (PMID: 21982860) Ramani S.R. … Gonzalez L.C. (Anal. Biochem. 2012) 3
  5. The human orthologue of murine Mpzl3 with predicted adhesive and immune functions is a potential candidate gene for immune-related hereditary hair loss. (PMID: 19054061) Racz P. … Csiszar K. (Exp. Dermatol. 2009) 3

Products for MPZL3 Gene

Sources for MPZL3 Gene