MPZL3 Gene
protein-coding GIFtS: 44
GCID: GC11M118097
|
|
myelin protein zero-like 3
| |
Aliases
for MPZL3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Myelin Protein Zero-Like 31 2 | | Myelin Protein Zero-Like Protein 32 |
Export aliases for MPZL3 gene to outside databasesPrevious GC identifers: GC11M117604 GC11M114033 |
Summaries
for MPZL3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MPZL3_HUMAN, Q6UWV2Function: Mediates homophilic cell-cell adhesion (By similarity)
|
Genomic Views
for MPZL3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MPZL3 gene promoter:
AhR AML1a GCNF Pax-6 Arnt PPAR-gamma1 GCNF-1 c-Myb PPAR-gamma2 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MPZL3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPZL3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3MPZL3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M118097: view genomic region
(about GC identifiers)
Start:
|
118,097,409 bp from pter |
End:
|
118,123,065 bp from pter |
Size:
|
25,657 bases |
Orientation:
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minus strand |
|
Proteins
for MPZL3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MPZL3_HUMAN, Q6UWV2 (See
protein sequence)Recommended Name: Myelin protein zero-like protein 3 precursor Size: 235 amino acids; 25989 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: A8K025Explore the universe of human proteins at neXtProt for MPZL3: NX_Q6UWV2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UWV2
MPZL3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_938016.1
ENSEMBL proteins: ENSP00000278949 ENSP00000434636 ENSP00000432106 ENSP00000393594
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MPZL3 for ontologies About GeneDecksing
MPZL3 Antibody Products:
Assay Products for MPZL3: |
Protein
Domains /
Families
for MPZL3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MPZL3 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UWV2ProtoNet protein and cluster: Q6UWV2 3 Blocks protein families: IPB003596 Immunoglobulin V-type IPB003599 Immunoglobulin subtype IPB013106 Immunoglobulin V-set
UniProtKB/Swiss-Prot: MPZL3_HUMAN, Q6UWV2Similarity: Belongs to the myelin P0 protein familySimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for MPZL3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MPZL3_HUMAN, Q6UWV2Function: Mediates homophilic cell-cell adhesion (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPZL3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPZL3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MPZL3 (NM_198275) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MPZL3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPZL3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPZL3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
MPZL3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MPZL3:
Animal Models:
11 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Mpzl3):
MPZL3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MPZL3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MPZL3
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for MPZL3 (Q6UWV21 ENSP000002789494) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
MPZL3 for ontologies About GeneDecksing
|
Drugs & Compounds
for MPZL3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MPZL3
Search CenterWatch for drugs/clinical trials and news about MPZL3
|
Transcripts
for MPZL3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MPZL3 gene: NM_198275.1 Unigene Cluster for MPZL3: Myelin protein zero-like 3 Hs.15396 [show with all ESTs]Unigene Representative Sequence: AK0953994 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000278949(uc001psm.3) ENST00000525386(uc009yzy.3) ENST00000527472(uc010rxy.2)
ENST00000446386(uc010rxz.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPZL3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPZL3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MPZL3 (NM_198275) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MPZL3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPZL3 |
Additional cDNA sequence: AK095399.1 AK289390.1 AK296951.1 AK304292.1 AK310966.1 AY358626.1 BC008810.2 BC031223.1 BC113586.1 BC143897.1 3 DOTS entries: DT.111820 DT.101970158 DT.100741078 24/55 AceView cDNA sequences (see all 55): BM723781 BM728451 AA932586 AA772172 AA868788 BF432194 AI123127 AA854326 AA053064 AA653368 BC008810 CF123039 AL712396 CF145719 T83955 CB851502 BE741718 BU742231 CD723887 AA960956 AI633538 AY358626 BF000260 NM_198275
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for MPZL3 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | | | | | | |
ECgene alternative splicing isoforms for MPZL3
|
Expression
for MPZL3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MPZL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGACCTGTTA
About this image
See MPZL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MPZL3
SOURCE GeneReport for Unigene cluster: Hs.15396
SABiosciences Custom PCR Arrays for MPZL3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPZL3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MPZL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPZL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPZL3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPZL3 |
Orthologs
for MPZL3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MPZL3 gene from 2/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MPZL31 |
myelin protein zero-like 3 |
62.77(n)
56.07(a) |
|
419778 NM_001252285.1 NP_001239214.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
mpzl31 |
myelin protein zero-like 3 |
46.44(n)
41.33(a) |
|
406448 NM_213169.1 NP_998334.1 |
ENSEMBL Gene Tree for MPZL3 (if available)
TreeFam Gene Tree for MPZL3 (if available) |
Paralogs
for MPZL3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MPZL3 gene
- MPZL22 SCN2B2 MPZ2 MPZL12 SCN4B2
4 SIMAP similar genes for MPZL3 using alignment to 4 protein entries: MPZL3_HUMAN (see all proteins):MPZ P0 MPZL1 MPZL2
MPZL3 for paralogs About GeneDecksing
|
Genomic Variants
for MPZL3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MPZL3 (118097409 - 118123065 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MPZL3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPZL3 |
|
Disorders
/ Diseases
for MPZL3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MPZL3 for disorders About MalaCards
MPZL3 for disorders About GeneDecksing
OMIM gene information: 611707
OMIM disorders: --
Export disorders for MPZL3 gene to outside databases
|
Publications
for MPZL3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MPZL3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MPZL3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutation in Mpzl3, a novel [corrected] gene encoding a predicted [corrected] adhesion protein, in the rough coat (rc) mice with severe skin and hair abnormalities. (PubMed id 17273165)1, 3 Cao T....Csiszar K. (2007)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- The human orthologue of murine Mpzl3 with predicted a dhesive and immune functions is a potential candidate gene for immune-related h ereditary hair loss. (PubMed id 19054061)1 Racz P....Csiszar K. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for MPZL3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MPZL3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MPZL3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MPZL3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MPZL3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MPZL3 gene:
Search GeneIP for patents involving MPZL3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MPZL3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MPZL3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPZL3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPZL3 | | | OriGene Protein Over-expression Lysate for MPZL3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MPZL3 | | OriGene 3'-UTR Clone for MPZL3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPZL3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPZL3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MPZL3 | | OriGene Custom Protein Services for MPZL3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MPZL3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPZL3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPZL3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPZL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPZL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPZL3 |
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| | | | Search Tocris compounds for MPZL3 |
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 | | | MPZL3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPZL3 |
|  |  |  | | | | Search ThermoFisher Antibodies for MPZL3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPZL3 |
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