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MPZL3 Gene

protein-coding   GIFtS: 46
GCID: GC11M118097

Myelin Protein Zero-Like 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myelin Protein Zero-Like 31 2
Myelin Protein Zero-Like Protein 32

External Ids:    HGNC: 272791   Entrez Gene: 1962642   Ensembl: ENSG000001605887   OMIM: 6117075   UniProtKB: Q6UWV23   

Export aliases for MPZL3 gene to outside databases

Previous GC identifers: GC11M117604 GC11M114033


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MPZL3 Gene:
MPZL3 (myelin protein zero-like 3) is a protein-coding gene. An important paralog of this gene is MPZL2.

UniProtKB/Swiss-Prot: MPZL3_HUMAN, Q6UWV2
Function: Mediates homophilic cell-cell adhesion (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MPZL3 gene promoter:
         AhR   AML1a   GCNF   Pax-6   Arnt   PPAR-gamma1   GCNF-1   c-Myb   PPAR-gamma2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMPZL3 promoter sequence
   Search Chromatin IP Primers for MPZL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MPZL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

MPZL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPZL3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M118097:  view genomic region     (about GC identifiers)

Start:
118,097,409 bp from pter      End:
118,123,065 bp from pter
Size:
25,657 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MPZL3_HUMAN, Q6UWV2 (See protein sequence)
Recommended Name: Myelin protein zero-like protein 3 precursor  
Size: 235 amino acids; 25989 Da
Secondary accessions: A8K025

Explore the universe of human proteins at neXtProt for MPZL3: NX_Q6UWV2

Explore proteomics data for MPZL3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn123

  • See MPZL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273081.1  NP_938016.1  

    ENSEMBL proteins: 
     ENSP00000278949   ENSP00000434636   ENSP00000432106   ENSP00000393594  

    MPZL3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MPZL3

     
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    antibodies-online proteins for MPZL3 (3 products) 

     
    antibodies-online peptides for MPZL3

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    antibodies-online antibodies for MPZL3 (11 products) 

    MPZL3 Assay Products:

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    Cloud-Clone Corp. ELISAs for MPZL3
    Cloud-Clone Corp. CLIAs for MPZL3
    Search eBioscience for ELISAs for MPZL3 
    antibodies-online kits for MPZL3 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR000920 Myelin_P0

    Graphical View of Domain Structure for InterPro Entry Q6UWV2

    ProtoNet protein and cluster: Q6UWV2

    3 Blocks protein domains:
    IPB003596 Immunoglobulin V-type
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: MPZL3_HUMAN, Q6UWV2
    Similarity: Belongs to the myelin P0 protein family
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with MPZL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPZL3_HUMAN, Q6UWV2
    Function: Mediates homophilic cell-cell adhesion (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with MPZL3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MPZL3:
     Metaphase cells 

         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mpzl3):
     behavior/neurological  cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  muscle  pigmentation 
     skeleton 

    Find genes that share phenotypes with MPZL3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MPZL3

    miRNA
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    Block miRNA regulation of human, mouse, rat MPZL3 using miScript Target Protectors
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    GenScript: all cDNA clones in your preferred vector: MPZL3 (NM_198275)
    Sino Biological Human cDNA Clone for MPZL3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPZL3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPZL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MPZL3_HUMAN, Q6UWV2: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with MPZL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MPZL3
    Interactions:

        Search GeneGlobe Interaction Network for MPZL3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for MPZL3 (Q6UWV21 ENSP000002789494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPZL2O604871, ENSP000002789374EBI-4314854,EBI-3906725 STRING: ENSP00000278937
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0030198extracellular matrix organization IEA--
    GO:0042633hair cycle IEA--

    Find genes that share ontologies with MPZL3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MPZL3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MPZL3 gene (2 alternative transcripts): 
    NM_001286152.1  NM_198275.2  

    Unigene Cluster for MPZL3:

    Myelin protein zero-like 3
    Hs.15396  [show with all ESTs]
    Unigene Representative Sequence: AK095399
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278949(uc001psm.3) ENST00000525386(uc009yzy.3) ENST00000527472(uc010rxy.2)
    ENST00000446386(uc010rxz.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat MPZL3 using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat MPZL3
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPZL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPZL3
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat MPZL3
      QuantiFast Probe-based Assays in human, mouse, rat MPZL3

    Additional mRNA sequence: 

    AK095399.1 AK289390.1 AK296951.1 AK304292.1 AK310966.1 AY358626.1 BC008810.2 BC031223.1 
    BC113586.1 BC143897.1 

    3 DOTS entries:

    DT.111820  DT.101970158  DT.100741078 

    Selected AceView cDNA sequences (see all 55):

    AI123127 AA868788 AA854326 AA772172 BF432194 BM728451 AA053064 BM723781 
    AA932586 CB851502 BF000260 BE741718 CD723887 CF123039 AI633538 AA053408 
    BU742231 AA960956 CF145765 BC008810 CB321722 AL712396 AA653368 NM_198275 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MPZL3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                                                
    SP2:              -     -     -                     


    ECgene alternative splicing isoforms for MPZL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MPZL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACCTGTTA
    MPZL3 Expression
    About this image

    MPZL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MPZL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.15396
        Custom PCR Arrays for MPZL3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPZL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MPZL3 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mpzl31 , 5 myelin protein zero-like 31, 5 85.07(n)1
    88.26(a)1
      9 (24.84 cM)5
    3197421  NM_001093749.21  NP_001087218.11 
     450551865 
    chicken
    (Gallus gallus)
    Aves MPZL31 myelin protein zero-like 3 62.62(n)
    56.07(a)
      419778  NM_001252285.1  NP_001239214.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mpzl31 myelin protein zero-like 3 55.61(n)
    46.92(a)
      100145167  NM_001126663.1  NP_001120135.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mpzl36
    myelin protein zero-like 3
    29(a)
    1 ↔ 1
    15(46727455-46734241) ENSDARG00000079225


    ENSEMBL Gene Tree for MPZL3 (if available)
    TreeFam Gene Tree for MPZL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MPZL3 gene
    MPZL22  SCN2B2  MPZ2  MPZL12  SCN4B2  
    4 SIMAP similar genes for MPZL3 using alignment to 4 protein entries:     MPZL3_HUMAN (see all proteins):
    MPZ    P0    MPZL1    MPZL2

    Find genes that share paralogs with MPZL3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MPZL3 (see all 536)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1854581371,2
    --117963549(+) AAATAA/GCAAAG 1 -- ds50010--------
    rs1408970761,2
    C--117963814(+) GGAGC-/AAAAAA 1 -- ds50010--------
    rs123617911,2
    C,F,H--117963845(+) GCGAAT/GATTTT 1 -- ds500113Minor allele frequency- G:0.04NS EA NA 1392
    rs1903771501,2
    --117963967(+) TGTAAC/TACATT 1 -- ds50010--------
    rs769685811,2
    --117963994(+) TCAAAA/CAGTAT 1 -- ds50010--------
    rs1484341091,2
    --117964000(+) AGTATA/CTTTTT 1 -- ds50010--------
    rs8696381,2
    C,F,O,A,H--117964080(+) TGAGAG/CTTCCT 1 -- ut3116Minor allele frequency- C:0.44NS EA NA WA 920
    rs1451583101,2
    C--117964081(+) GAGAGC/TTCCTG 1 -- ut310--------
    rs1825043631,2
    --117964166(+) GGATTA/GTCCAT 1 -- ut310--------
    rs9392721,2
    C,F,H--117964173(-) CATAGC/TGATGG 1 -- ut31 ese319Minor allele frequency- T:0.18MN NS EA NA WA CSA 1646

    HapMap Linkage Disequilibrium report for MPZL3 (118097409 - 118123065 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MPZL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv511CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MPZL3
    DNA2.0 Custom Variant and Variant Library Synthesis for MPZL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611707    OMIM disorders: --


    Find genes that share disorders with MPZL3           About GenesLikeMe


    Export disorders for MPZL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MPZL3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MPZL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation in Mpzl3, a novel [corrected] gene encoding a predicted [corrected] adhesion protein, in the rough coat (rc) mice with severe skin and hair abnormalities. (PubMed id 17273165)1, 3 Cao T....Csiszar K. (J. Invest. Dermatol. 2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PubMed id 23400010)1 Del-Aguila J.L....Boerwinkle E. (Pharmacogenomics J. 2013)
    7. A secreted protein microarray platform for extracellular protein interaction discovery. (PubMed id 21982860)1 Ramani S.R....Gonzalez L.C. (Anal. Biochem. 2012)
    8. The human orthologue of murine Mpzl3 with predicted adhesive and immune functions is a potential candidate gene for immune-related hereditary hair loss. (PubMed id 19054061)1 Racz P....Csiszar K. (Exp. Dermatol. 2009)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 196264 HGNC: 27279 AceView: LOC196264 Ensembl:ENSG00000160588 euGenes: HUgn196264
    ECgene: MPZL3 H-InvDB: MPZL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MPZL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MPZL3 gene:
    Search GeneIP for patents involving MPZL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

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