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Aliases for MPZL3 Gene

Aliases for MPZL3 Gene

  • Myelin Protein Zero Like 3 2 3 5

External Ids for MPZL3 Gene

Previous GeneCards Identifiers for MPZL3 Gene

  • GC11M117604
  • GC11M118097
  • GC11M114033

Summaries for MPZL3 Gene

GeneCards Summary for MPZL3 Gene

MPZL3 (Myelin Protein Zero Like 3) is a Protein Coding gene. An important paralog of this gene is MPZ.

UniProtKB/Swiss-Prot for MPZL3 Gene

  • Mediates homophilic cell-cell adhesion.

Additional gene information for MPZL3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPZL3 Gene

Genomics for MPZL3 Gene

Regulatory Elements for MPZL3 Gene

Enhancers for MPZL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H118238 2 FANTOM5 Ensembl ENCODE dbSUPER 25.5 +11.8 11807 5.1 FOXA2 PKNOX1 ARNT SIN3A YY1 ZNF766 ZNF207 FOS ZC3H11A JUNB ENSG00000254909 JAML RPL23AP64 UBE4A ENSG00000254428 BCL9L MPZL3 ARCN1 DPAGT1 CD3E
GH11H118309 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15 -62.7 -62733 11 HDGF PKNOX1 FOXA2 ATF1 ARNT FEZF1 ZNF766 CBX5 GATA2 ZNF143 CD3G CD3D MPZL3 UBE4A KMT2A CD3E ENSG00000255384 HMBS ARCN1 ENSG00000271751
GH11H118210 1.5 Ensembl ENCODE dbSUPER 17.8 +38.0 37985 8 HDGF FOXA2 ATF1 MLX ARID4B DMAP1 YY1 ZNF143 ATF7 RUNX3 MPZL3 JAML CD3D CD3G CD3E MPZL2 GC11M118201 HSPE1P18
GH11H118263 1.4 Ensembl ENCODE dbSUPER 18.4 -12.6 -12577 4.8 TBP ARID4B SIN3A DMAP1 ZBTB40 RAD21 RFX5 YY1 ZNF366 SCRT2 MPZL3 ENSG00000271751 CD3E ENSG00000280032
GH11H118223 1.1 ENCODE dbSUPER 21.4 +25.6 25615 7.3 PKNOX1 TBL1XR1 BMI1 BATF ZNF143 ATF7 ETV6 RUNX3 CREM IKZF2 MPZL3 SCN2B MPZL2 JAML PIR47429
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MPZL3 on UCSC Golden Path with GeneCards custom track

Promoters for MPZL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for MPZL3 Gene

Genomic Locations for MPZL3 Gene
25,679 bases
Minus strand

Genomic View for MPZL3 Gene

Genes around MPZL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPZL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPZL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPZL3 Gene

Proteins for MPZL3 Gene

  • Protein details for MPZL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myelin protein zero-like protein 3
    Protein Accession:
    Secondary Accessions:
    • A8K025
    • B4DLD5
    • B4E2I8

    Protein attributes for MPZL3 Gene

    235 amino acids
    Molecular mass:
    25989 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MPZL3 Gene


neXtProt entry for MPZL3 Gene

Post-translational modifications for MPZL3 Gene

  • Glycosylation at posLast=123123
  • Modification sites at PhosphoSitePlus

Other Protein References for MPZL3 Gene

No data available for DME Specific Peptides for MPZL3 Gene

Domains & Families for MPZL3 Gene

Gene Families for MPZL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for MPZL3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the myelin P0 protein family.
  • Belongs to the myelin P0 protein family.
genes like me logo Genes that share domains with MPZL3: view

Function for MPZL3 Gene

Molecular function for MPZL3 Gene

UniProtKB/Swiss-Prot Function:
Mediates homophilic cell-cell adhesion.

Phenotypes From GWAS Catalog for MPZL3 Gene

Gene Ontology (GO) - Molecular Function for MPZL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with MPZL3: view
genes like me logo Genes that share phenotypes with MPZL3: view

Animal Models for MPZL3 Gene

MGI Knock Outs for MPZL3:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MPZL3 Gene

Localization for MPZL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPZL3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPZL3 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MPZL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MPZL3: view

Pathways & Interactions for MPZL3 Gene

SuperPathways for MPZL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MPZL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0030198 extracellular matrix organization IEA --
GO:0042633 hair cycle IEA --
genes like me logo Genes that share ontologies with MPZL3: view

No data available for Pathways by source and SIGNOR curated interactions for MPZL3 Gene

Drugs & Compounds for MPZL3 Gene

No Compound Related Data Available

Transcripts for MPZL3 Gene

Unigene Clusters for MPZL3 Gene

Myelin protein zero-like 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPZL3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP2: - - -

Relevant External Links for MPZL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPZL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MPZL3 Gene

mRNA differential expression in normal tissues according to GTEx for MPZL3 Gene

This gene is overexpressed in Whole Blood (x9.8), Esophagus - Mucosa (x5.9), Skin - Not Sun Exposed (Suprapubic) (x5.5), and Skin - Sun Exposed (Lower leg) (x5.4).

Protein differential expression in normal tissues from HIPED for MPZL3 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MPZL3 Gene

Protein tissue co-expression partners for MPZL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MPZL3 Gene:


SOURCE GeneReport for Unigene cluster for MPZL3 Gene:


Evidence on tissue expression from TISSUES for MPZL3 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with MPZL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPZL3 Gene

Orthologs for MPZL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MPZL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MPZL3 33 34
  • 99.15 (n)
(Canis familiaris)
Mammalia MPZL3 33 34
  • 89.36 (n)
(Bos Taurus)
Mammalia MPZL3 33 34
  • 87.46 (n)
(Mus musculus)
Mammalia Mpzl3 33 16 34
  • 85.07 (n)
(Rattus norvegicus)
Mammalia Mpzl3 33
  • 84.54 (n)
(Monodelphis domestica)
Mammalia MPZL3 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia MPZL3 34
  • 77 (a)
(Gallus gallus)
Aves MPZL3 33 34
  • 62.62 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia mpzl3 33
  • 55.61 (n)
(Danio rerio)
Actinopterygii mpzl3 34
  • 29 (a)
Species where no ortholog for MPZL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPZL3 Gene

Gene Tree for MPZL3 (if available)
Gene Tree for MPZL3 (if available)

Paralogs for MPZL3 Gene

Paralogs for MPZL3 Gene

(4) SIMAP similar genes for MPZL3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MPZL3: view

Variants for MPZL3 Gene

Sequence variations from dbSNP and Humsavar for MPZL3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000132067 -- 118,230,786(+) CATCT(A/G)TTTGG intron-variant
rs1000193693 -- 118,241,412(+) GGCTC(C/T)TACAC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000347859 -- 118,233,976(+) TGTCA(A/G)AGTGA intron-variant
rs1000506098 -- 118,243,129(+) CTGGA(A/C)AATTA intron-variant, upstream-variant-2KB
rs1000524339 -- 118,239,615(+) TAATA(C/T)ACCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPZL3 Gene

Variant ID Type Subtype PubMed ID
nsv952742 CNV duplication 24416366
nsv511 CNV insertion 18451855

Variation tolerance for MPZL3 Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.18; 69.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPZL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPZL3 Gene

Disorders for MPZL3 Gene

Relevant External Links for MPZL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MPZL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPZL3 Gene

Publications for MPZL3 Gene

  1. Mutation in Mpzl3, a novel [corrected] gene encoding a predicted [corrected] adhesion protein, in the rough coat (rc) mice with severe skin and hair abnormalities. (PMID: 17273165) Cao T … Csiszar K (The Journal of investigative dermatology 2007) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60

Products for MPZL3 Gene

Sources for MPZL3 Gene

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