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Aliases for MPZL2 Gene

Aliases for MPZL2 Gene

  • Myelin Protein Zero Like 2 2 3 5
  • Epithelial V-Like Antigen 1 2 3 4
  • EVA1 3 4
  • EVA 3 4
  • Myelin Protein Zero-Like Protein 2 3

External Ids for MPZL2 Gene

Previous HGNC Symbols for MPZL2 Gene

  • EVA1

Previous GeneCards Identifiers for MPZL2 Gene

  • GC11M117630
  • GC11M118124
  • GC11M114057

Summaries for MPZL2 Gene

Entrez Gene Summary for MPZL2 Gene

  • Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MPZL2 Gene

MPZL2 (Myelin Protein Zero Like 2) is a Protein Coding gene. Diseases associated with MPZL2 include Pendred Syndrome and Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct. An important paralog of this gene is MPZL3.

UniProtKB/Swiss-Prot for MPZL2 Gene

  • Mediates homophilic cell-cell adhesion.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPZL2 Gene

Genomics for MPZL2 Gene

Regulatory Elements for MPZL2 Gene

Enhancers for MPZL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MPZL2 on UCSC Golden Path with GeneCards custom track

Promoters for MPZL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MPZL2 Gene

118,253,403 bp from pter
118,264,536 bp from pter
11,134 bases
Minus strand

Genomic View for MPZL2 Gene

Genes around MPZL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPZL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPZL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPZL2 Gene

Proteins for MPZL2 Gene

  • Protein details for MPZL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myelin protein zero-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K2R1

    Protein attributes for MPZL2 Gene

    215 amino acids
    Molecular mass:
    24484 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MPZL2 Gene

Post-translational modifications for MPZL2 Gene

  • Glycosylation at Asn 39 and Asn 118
  • Modification sites at PhosphoSitePlus

Other Protein References for MPZL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MPZL2 Gene

Domains & Families for MPZL2 Gene

Gene Families for MPZL2 Gene

Protein Domains for MPZL2 Gene

Suggested Antigen Peptide Sequences for MPZL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the myelin P0 protein family.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the myelin P0 protein family.
genes like me logo Genes that share domains with MPZL2: view

Function for MPZL2 Gene

Molecular function for MPZL2 Gene

UniProtKB/Swiss-Prot Function:
Mediates homophilic cell-cell adhesion.

Gene Ontology (GO) - Molecular Function for MPZL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with MPZL2: view

Phenotypes for MPZL2 Gene

genes like me logo Genes that share phenotypes with MPZL2: view

Animal Models for MPZL2 Gene

MGI Knock Outs for MPZL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for MPZL2

CRISPR Products

miRNA for MPZL2 Gene

miRTarBase miRNAs that target MPZL2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MPZL2 Gene

Localization for MPZL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPZL2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for MPZL2 Gene COMPARTMENTS Subcellular localization image for MPZL2 gene
Compartment Confidence
cytoskeleton 4
plasma membrane 4
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MPZL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton TAS 9585423
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MPZL2: view

Pathways & Interactions for MPZL2 Gene

SuperPathways for MPZL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MPZL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules TAS 9585423
GO:0009653 anatomical structure morphogenesis TAS 9585423
GO:0016337 single organismal cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with MPZL2: view

No data available for Pathways by source and SIGNOR curated interactions for MPZL2 Gene

Drugs & Compounds for MPZL2 Gene

No Compound Related Data Available

Transcripts for MPZL2 Gene

Unigene Clusters for MPZL2 Gene

Myelin protein zero-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPZL2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: -
SP6: -
SP7: -
SP8: -

Relevant External Links for MPZL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPZL2 Gene

mRNA expression in normal human tissues for MPZL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MPZL2 Gene

This gene is overexpressed in Esophagus - Mucosa (x10.9) and Vagina (x5.6).

Protein differential expression in normal tissues from HIPED for MPZL2 Gene

This gene is overexpressed in Nasal epithelium (66.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MPZL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MPZL2 Gene:


SOURCE GeneReport for Unigene cluster for MPZL2 Gene:


mRNA Expression by UniProt/SwissProt for MPZL2 Gene:

Tissue specificity: Expressed in thymocytes and thymic stromal cells; expression elevated in some T-cell leukemias.
genes like me logo Genes that share expression patterns with MPZL2: view

Primer Products

No data available for Protein tissue co-expression partners for MPZL2 Gene

Orthologs for MPZL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MPZL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MPZL2 34
  • 89.92 (n)
  • 89.77 (a)
MPZL2 35
  • 90 (a)
(Canis familiaris)
Mammalia MPZL2 34
  • 89.15 (n)
  • 89.3 (a)
MPZL2 35
  • 89 (a)
(Mus musculus)
Mammalia Mpzl2 34
  • 84.34 (n)
  • 81.4 (a)
Mpzl2 16
Mpzl2 35
  • 81 (a)
(Pan troglodytes)
Mammalia MPZL2 34
  • 99.38 (n)
  • 99.53 (a)
MPZL2 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Mpzl2 34
  • 83.72 (n)
  • 82.33 (a)
(Monodelphis domestica)
Mammalia MPZL2 35
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia MPZL2 35
  • 71 (a)
(Gallus gallus)
Aves MPZL2 34
  • 64.48 (n)
  • 59.02 (a)
MPZL2 35
  • 58 (a)
(Anolis carolinensis)
Reptilia MPZL2 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mpzl2 34
  • 56.46 (n)
  • 48.47 (a)
(Danio rerio)
Actinopterygii LOC100534682 34
  • 51.99 (n)
  • 44.56 (a)
MPZL2 (2 of 2) 35
  • 38 (a)
mpzl2b 35
  • 38 (a)
Species where no ortholog for MPZL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPZL2 Gene

Gene Tree for MPZL2 (if available)
Gene Tree for MPZL2 (if available)

Paralogs for MPZL2 Gene

Paralogs for MPZL2 Gene

(5) SIMAP similar genes for MPZL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MPZL2: view

Variants for MPZL2 Gene

Sequence variations from dbSNP and Humsavar for MPZL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1056562 -- 118,254,910(-) TCAAA(A/G)GGGAT utr-variant-3-prime
rs1058027 -- 118,256,989(-) GTTAT(C/T)TGTGG intron-variant, utr-variant-3-prime
rs1104542 -- 118,258,625(-) tgggc(A/G)gggac intron-variant
rs1624780 -- 118,264,070(-) CTCAG(A/C)GTTTC intron-variant
rs1628018 -- 118,256,038(-) ACCAA(C/T)GGCTA intron-variant

Variation tolerance for MPZL2 Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPZL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MPZL2 Gene

Disorders for MPZL2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MPZL2 Gene - From: OMIM

Disorder Aliases PubMed IDs
pendred syndrome
  • pds
deafness, autosomal recessive 4, with enlarged vestibular aqueduct
  • enlarged vestibular aqueduct, digenic
- elite association - COSMIC cancer census association via MalaCards
Search MPZL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MPZL2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MPZL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MPZL2 Gene

Publications for MPZL2 Gene

  1. Epithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesis. (PMID: 9585423) Guttinger M. … Grassi F. (J. Cell Biol. 1998) 2 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 65
  4. Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-I_B Signaling Pathway. (PMID: 26677976) Ohtsu N. … Kondo T. (Cancer Res. 2016) 3 65
  5. CLCA2 Interactor EVA1 Is Required for Mammary Epithelial Cell Differentiation. (PMID: 26930581) Ramena G. … Elble R.C. (PLoS ONE 2016) 3 65

Products for MPZL2 Gene

Sources for MPZL2 Gene

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