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Aliases for MPZL2 Gene

Aliases for MPZL2 Gene

  • Myelin Protein Zero-Like 2 2 3
  • Epithelial V-Like Antigen 1 2 3 4
  • EVA1 3 4 6
  • EVA 3 4 6
  • Myelin Protein Zero-Like Protein 2 3

External Ids for MPZL2 Gene

Previous Symbols for MPZL2 Gene

  • EVA1

Summaries for MPZL2 Gene

Entrez Gene Summary for MPZL2 Gene

  • Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MPZL2 Gene

MPZL2 (Myelin Protein Zero-Like 2) is a Protein Coding gene. An important paralog of this gene is MPZL1.

UniProtKB/Swiss-Prot for MPZL2 Gene

  • Mediates homophilic cell-cell adhesion

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPZL2 Gene

Genomics for MPZL2 Gene

Genomic Location for MPZL2 Gene

Start:
118,253,403 bp from pter
End:
118,264,536 bp from pter
Size:
11,134 bases
Orientation:
Minus strand

Genomic View for MPZL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPZL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPZL2 Gene

Regulatory Elements for MPZL2 Gene

Proteins for MPZL2 Gene

  • Protein details for MPZL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60487-MPZL2_HUMAN
    Recommended name:
    Myelin protein zero-like protein 2
    Protein Accession:
    O60487
    Secondary Accessions:
    • A8K2R1

    Protein attributes for MPZL2 Gene

    Size:
    215 amino acids
    Molecular mass:
    24484 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MPZL2 Gene

Proteomics data for MPZL2 Gene at MOPED

Post-translational modifications for MPZL2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn39 and Asn118

Other Protein References for MPZL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MPZL2 Gene

Domains for MPZL2 Gene

Gene Families for MPZL2 Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for MPZL2 Gene

UniProtKB/Swiss-Prot:

MPZL2_HUMAN
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • O60487
Family:
  • Belongs to the myelin P0 protein family.:
    • O60487
genes like me logo Genes that share domains with MPZL2: view

Function for MPZL2 Gene

Molecular function for MPZL2 Gene

UniProtKB/Swiss-Prot Function: Mediates homophilic cell-cell adhesion

Gene Ontology (GO) - Molecular Function for MPZL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with MPZL2: view

Phenotypes for MPZL2 Gene

genes like me logo Genes that share phenotypes with MPZL2: view

Animal Models for MPZL2 Gene

MGI Knock Outs for MPZL2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MPZL2 Gene

Localization for MPZL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPZL2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MPZL2 Gene COMPARTMENTS Subcellular localization image for MPZL2 gene
Compartment Confidence
cytoskeleton 4
plasma membrane 3
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MPZL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton TAS 9585423
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MPZL2: view

Pathways for MPZL2 Gene

SuperPathways for MPZL2 Gene

No Data Available

Interacting Proteins for MPZL2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000278937%0d%0a9606.ENSP00000278949%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000336790%0d%0a
Selected Interacting proteins: ENSP00000278937 O60487-MPZL2_HUMAN for MPZL2 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for MPZL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules TAS 9585423
GO:0009653 anatomical structure morphogenesis TAS 9585423
GO:0016337 single organismal cell-cell adhesion --
GO:0033077 T cell differentiation in thymus IEA --
genes like me logo Genes that share ontologies with MPZL2: view

No data available for Pathways by source for MPZL2 Gene

Transcripts for MPZL2 Gene

Unigene Clusters for MPZL2 Gene

Myelin protein zero-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MPZL2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: -
SP6: -
SP7: -
SP8: -

Relevant External Links for MPZL2 Gene

GeneLoc Exon Structure for
MPZL2
ECgene alternative splicing isoforms for
MPZL2

Expression for MPZL2 Gene

mRNA expression in normal human tissues for MPZL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MPZL2 Gene

This gene is overexpressed in Esophagus - Mucosa (10.9) and Vagina (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPZL2 Gene

SOURCE GeneReport for Unigene cluster for MPZL2 Gene Hs.116651

mRNA Expression by UniProt/SwissProt for MPZL2 Gene

O60487-MPZL2_HUMAN
Tissue specificity: Expressed in thymocytes and thymic stromal cells; expression elevated in some T-cell leukemias
genes like me logo Genes that share expressions with MPZL2: view

Orthologs for MPZL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MPZL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MPZL2 36
  • 99.38 (n)
  • 99.53 (a)
MPZL2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MPZL2 36
  • 89.92 (n)
  • 89.77 (a)
MPZL2 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MPZL2 36
  • 89.15 (n)
  • 89.3 (a)
MPZL2 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mpzl2 36
  • 84.34 (n)
  • 81.4 (a)
Mpzl2 16
Mpzl2 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MPZL2 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MPZL2 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mpzl2 36
  • 83.72 (n)
  • 82.33 (a)
chicken
(Gallus gallus)
Aves MPZL2 36
  • 64.48 (n)
  • 59.02 (a)
MPZL2 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MPZL2 37
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mpzl2 36
  • 56.46 (n)
  • 48.47 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100534682 36
  • 51.99 (n)
  • 44.56 (a)
MPZL2 (2 of 2) 37
  • 38 (a)
OneToMany
mpzl2b 37
  • 38 (a)
OneToMany
Species with no ortholog for MPZL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPZL2 Gene

ENSEMBL:
Gene Tree for MPZL2 (if available)
TreeFam:
Gene Tree for MPZL2 (if available)

Paralogs for MPZL2 Gene

Paralogs for MPZL2 Gene

Selected SIMAP similar genes for MPZL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MPZL2: view

Variants for MPZL2 Gene

Sequence variations from dbSNP and Humsavar for MPZL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs939273 -- 118,263,352(-) AGGCT(A/T)TAATG intron-variant
rs939274 -- 118,263,350(-) GCTTT(A/C)ATGCT intron-variant
rs1056562 -- 118,254,910(-) TCAAA(A/G)GGGAT utr-variant-3-prime
rs1058027 -- 118,256,989(-) GTTAT(C/T)TGTGG intron-variant, utr-variant-3-prime
rs1104542 -- 118,258,625(-) tgggc(A/G)gggac intron-variant

Relevant External Links for MPZL2 Gene

HapMap Linkage Disequilibrium report
MPZL2

No data available for Structural Variations from Database of Genomic Variants (DGV) for MPZL2 Gene

Disorders for MPZL2 Gene

Relevant External Links for MPZL2

Genetic Association Database (GAD)
MPZL2
genes like me logo Genes that share disorders with MPZL2: view

No data available for UniProtKB/Swiss-Prot for MPZL2 Gene

Publications for MPZL2 Gene

  1. Epithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesis. (PMID: 9585423) Guttinger M. … Grassi F. (J. Cell Biol. 1998) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for MPZL2 Gene

Sources for MPZL2 Gene

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