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Aliases for MPZL1 Gene

Aliases for MPZL1 Gene

  • Myelin Protein Zero-Like 1 2 3
  • Protein Zero-Related 3 4
  • PZR 3 4
  • Immunoglobulin Family Transmembrane Protein 3
  • Myelin Protein Zero-Like Protein 1 3
  • Protein Zero Related 3
  • MPZL1b 3
  • PZR1b 3
  • PZRa 3
  • PZRb 3

External Ids for MPZL1 Gene

Previous GeneCards Identifiers for MPZL1 Gene

  • GC01P165326
  • GC01P163342
  • GC01P164387
  • GC01P164878
  • GC01P164422
  • GC01P165957
  • GC01P167690
  • GC01P138937

Summaries for MPZL1 Gene

GeneCards Summary for MPZL1 Gene

MPZL1 (Myelin Protein Zero-Like 1) is a Protein Coding gene. Among its related pathways are Tyrosine Kinases / Adaptors and Adhesion. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is SCN2B.

UniProtKB/Swiss-Prot for MPZL1 Gene

  • Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.

Gene Wiki entry for MPZL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPZL1 Gene

Genomics for MPZL1 Gene

Regulatory Elements for MPZL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MPZL1 Gene

Start:
167,721,192 bp from pter
End:
167,791,919 bp from pter
Size:
70,728 bases
Orientation:
Plus strand

Genomic View for MPZL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPZL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPZL1 Gene

Proteins for MPZL1 Gene

  • Protein details for MPZL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95297-MPZL1_HUMAN
    Recommended name:
    Myelin protein zero-like protein 1
    Protein Accession:
    O95297
    Secondary Accessions:
    • B2REB9
    • B2REC0
    • Q5R332
    • Q8IX11
    • Q9BWZ3
    • Q9NYK4
    • Q9UL20

    Protein attributes for MPZL1 Gene

    Size:
    269 amino acids
    Molecular mass:
    29082 Da
    Quaternary structure:
    • Interacts with phosphorylated PTPN11/SHP-2.
    SequenceCaution:
    • Sequence=CAI20144.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MPZL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPZL1 Gene

Proteomics data for MPZL1 Gene at MOPED

Post-translational modifications for MPZL1 Gene

  • N-glycosylated.
  • Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at Tyr-241 and Tyr-263 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro).
  • Ubiquitination at Lys257
  • Glycosylation at Asn50 and Asn130
  • Modification sites at PhosphoSitePlus

Other Protein References for MPZL1 Gene

No data available for DME Specific Peptides for MPZL1 Gene

Domains for MPZL1 Gene

Gene Families for MPZL1 Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing

Graphical View of Domain Structure for InterPro Entry

O95297

UniProtKB/Swiss-Prot:

MPZL1_HUMAN :
  • O95297
Domain:
  • Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the myelin P0 protein family.
genes like me logo Genes that share domains with MPZL1: view

Function for MPZL1 Gene

Molecular function for MPZL1 Gene

UniProtKB/Swiss-Prot Function: Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.

Gene Ontology (GO) - Molecular Function for MPZL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity TAS 9792637
GO:0005515 protein binding IPI 10681522
genes like me logo Genes that share ontologies with MPZL1: view

Phenotypes for MPZL1 Gene

genes like me logo Genes that share phenotypes with MPZL1: view

Animal Model Products

CRISPR Products

miRNA for MPZL1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPZL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MPZL1 Gene

Localization for MPZL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPZL1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MPZL1 Gene COMPARTMENTS Subcellular localization image for MPZL1 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MPZL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0009986 cell surface IDA 19581412
GO:0016020 membrane --
genes like me logo Genes that share ontologies with MPZL1: view

Pathways for MPZL1 Gene

genes like me logo Genes that share pathways with MPZL1: view

Pathways by source for MPZL1 Gene

2 Cell Signaling Technology pathways for MPZL1 Gene
1 KEGG pathway for MPZL1 Gene

Gene Ontology (GO) - Biological Process for MPZL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 10681522
GO:0007267 cell-cell signaling TAS 9792637
genes like me logo Genes that share ontologies with MPZL1: view

Transcripts for MPZL1 Gene

Unigene Clusters for MPZL1 Gene

Myelin protein zero-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPZL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPZL1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - - - - -
SP6: -
SP7:

Relevant External Links for MPZL1 Gene

GeneLoc Exon Structure for
MPZL1
ECgene alternative splicing isoforms for
MPZL1

Expression for MPZL1 Gene

mRNA expression in normal human tissues for MPZL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPZL1 Gene

SOURCE GeneReport for Unigene cluster for MPZL1 Gene Hs.493919

mRNA Expression by UniProt/SwissProt for MPZL1 Gene

O95297-MPZL1_HUMAN
Tissue specificity: Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line.
genes like me logo Genes that share expressions with MPZL1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MPZL1 Gene

Orthologs for MPZL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MPZL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MPZL1 35
  • 99.63 (n)
  • 99.63 (a)
MPZL1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MPZL1 35
  • 90.71 (n)
  • 91.45 (a)
MPZL1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MPZL1 35
  • 91.3 (n)
  • 94.07 (a)
MPZL1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mpzl1 35
  • 84.88 (n)
  • 83.27 (a)
Mpzl1 16
Mpzl1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MPZL1 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mpzl1 35
  • 84.63 (n)
  • 82.53 (a)
chicken
(Gallus gallus)
Aves MPZL1 35
  • 69.52 (n)
  • 66.42 (a)
MPZL1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MPZL1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mpzl1 35
  • 60.63 (n)
  • 55.6 (a)
zebrafish
(Danio rerio)
Actinopterygii mpzl1l 35
  • 53.42 (n)
  • 47.44 (a)
mpzl1l 36
  • 42 (a)
OneToOne
Species with no ortholog for MPZL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPZL1 Gene

ENSEMBL:
Gene Tree for MPZL1 (if available)
TreeFam:
Gene Tree for MPZL1 (if available)

Paralogs for MPZL1 Gene

Paralogs for MPZL1 Gene

Selected SIMAP similar genes for MPZL1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for MPZL1 Gene

genes like me logo Genes that share paralogs with MPZL1: view

Variants for MPZL1 Gene

Sequence variations from dbSNP and Humsavar for MPZL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7605 -- 167,790,044(+) CACAT(C/T)GTAGA utr-variant-3-prime
rs8623 -- 167,790,601(+) CTGCC(C/T)TCTCC utr-variant-3-prime
rs8917 -- 167,790,514(-) AAAAG(A/G)GCTGC utr-variant-3-prime
rs10125 -- 167,789,414(+) TCTCC(C/T)TGTAG utr-variant-3-prime
rs12316 -- 167,790,665(-) GAGTG(C/T)TCCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MPZL1 Gene

Variant ID Type Subtype PubMed ID
esv268743 CNV Insertion 20981092
nsv523174 CNV Loss 19592680

Relevant External Links for MPZL1 Gene

HapMap Linkage Disequilibrium report
MPZL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPZL1 Gene

Disorders for MPZL1 Gene

(1) University of Copenhagen DISEASES for MPZL1 Gene

Relevant External Links for MPZL1

Genetic Association Database (GAD)
MPZL1
Human Genome Epidemiology (HuGE) Navigator
MPZL1
genes like me logo Genes that share disorders with MPZL1: view

No data available for UniProtKB/Swiss-Prot for MPZL1 Gene

Publications for MPZL1 Gene

  1. Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2. (PMID: 9792637) Zhao Z.J. … Zhao R. (J. Biol. Chem. 1998) 2 3 4
  2. Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration. (PMID: 12410637) Zannettino A.C.W. … Watt S.M. (Biochem. J. 2003) 3 4 23
  3. Identification of a variant form of PZR lacking immunoreceptor tyrosine-based inhibitory motifs. (PMID: 12684038) Zhao R. … Zhao Z.J. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs. (PMID: 10681522) Zhao R. … Zhao Z.J. (J. Biol. Chem. 2000) 3 4

Products for MPZL1 Gene

Sources for MPZL1 Gene

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