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Aliases for MPV17L2 Gene

Aliases for MPV17L2 Gene

  • MPV17 Mitochondrial Membrane Protein-Like 2 2 3
  • FKSG24 3 4
  • Mpv17-Like Protein 2 3

External Ids for MPV17L2 Gene

Previous GeneCards Identifiers for MPV17L2 Gene

  • GC19P018167
  • GC19P018304
  • GC19P017867
  • GC19P018421

Summaries for MPV17L2 Gene

GeneCards Summary for MPV17L2 Gene

MPV17L2 (MPV17 Mitochondrial Membrane Protein-Like 2) is a Protein Coding gene. Among its related pathways are Peroxisome. An important paralog of this gene is MPV17.

UniProtKB/Swiss-Prot for MPV17L2 Gene

  • Required for the assembly and stability of the mitochondrial ribosome (PubMed:24948607). Is a positive regulator of mitochondrial protein synthesis (PubMed:24948607).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPV17L2 Gene

Genomics for MPV17L2 Gene

Regulatory Elements for MPV17L2 Gene

Genomic Location for MPV17L2 Gene

Start:
18,193,182 bp from pter
End:
18,196,948 bp from pter
Size:
3,767 bases
Orientation:
Plus strand

Genomic View for MPV17L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPV17L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPV17L2 Gene

Proteins for MPV17L2 Gene

  • Protein details for MPV17L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q567V2-M17L2_HUMAN
    Recommended name:
    Mpv17-like protein 2
    Protein Accession:
    Q567V2
    Secondary Accessions:
    • Q96P34
    • Q96QA0
    • Q9BSG4

    Protein attributes for MPV17L2 Gene

    Size:
    206 amino acids
    Molecular mass:
    23180 Da
    Quaternary structure:
    • Interacts with the large mitochondrial ribosomal subunit.

    Alternative splice isoforms for MPV17L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPV17L2 Gene

Proteomics data for MPV17L2 Gene at MOPED

Post-translational modifications for MPV17L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MPV17L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MPV17L2 Gene

Domains for MPV17L2 Gene

Protein Domains for MPV17L2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MPV17L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q567V2

UniProtKB/Swiss-Prot:

M17L2_HUMAN :
  • Q567V2
Family:
  • Belongs to the peroxisomal membrane protein PXMP2/4 family.
genes like me logo Genes that share domains with MPV17L2: view

No data available for Gene Families for MPV17L2 Gene

Function for MPV17L2 Gene

Molecular function for MPV17L2 Gene

UniProtKB/Swiss-Prot Function: Required for the assembly and stability of the mitochondrial ribosome (PubMed:24948607). Is a positive regulator of mitochondrial protein synthesis (PubMed:24948607).

Phenotypes for MPV17L2 Gene

GenomeRNAi human phenotypes for MPV17L2:
genes like me logo Genes that share phenotypes with MPV17L2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPV17L2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MPV17L2 Gene

Localization for MPV17L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPV17L2 Gene

Membrane; Multi-pass membrane protein. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MPV17L2 Gene COMPARTMENTS Subcellular localization image for MPV17L2 gene
Compartment Confidence
mitochondrion 3
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MPV17L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IDA 24948607
GO:0005762 mitochondrial large ribosomal subunit IDA 24948607
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MPV17L2: view

Pathways for MPV17L2 Gene

SuperPathways for MPV17L2 Gene

Superpath Contained pathways
1 Peroxisome
genes like me logo Genes that share pathways with MPV17L2: view

Pathways by source for MPV17L2 Gene

1 KEGG pathway for MPV17L2 Gene

Interacting Proteins for MPV17L2 Gene

Gene Ontology (GO) - Biological Process for MPV17L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061668 mitochondrial ribosome assembly IMP 24948607
GO:0070131 positive regulation of mitochondrial translation IMP 24948607
genes like me logo Genes that share ontologies with MPV17L2: view

Transcripts for MPV17L2 Gene

mRNA/cDNA for MPV17L2 Gene

Unigene Clusters for MPV17L2 Gene

MPV17 mitochondrial membrane protein-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPV17L2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPV17L2 Gene

No ASD Table

Relevant External Links for MPV17L2 Gene

GeneLoc Exon Structure for
MPV17L2
ECgene alternative splicing isoforms for
MPV17L2

Expression for MPV17L2 Gene

mRNA expression in normal human tissues for MPV17L2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MPV17L2 Gene

SOURCE GeneReport for Unigene cluster for MPV17L2 Gene Hs.515254

genes like me logo Genes that share expressions with MPV17L2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MPV17L2 Gene

Orthologs for MPV17L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MPV17L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MPV17L2 35
  • 99.84 (n)
  • 100 (a)
MPV17L2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MPV17L2 35
  • 85.71 (n)
  • 87.19 (a)
MPV17L2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MPV17L2 35
  • 84.93 (n)
  • 86.7 (a)
MPV17L2 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mpv17l2 35
  • 79.4 (n)
  • 79.9 (a)
Mpv17l2 16
Mpv17l2 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MPV17L2 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MPV17L2 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mpv17l2 35
  • 78.56 (n)
  • 79.4 (a)
chicken
(Gallus gallus)
Aves MPV17L2 35
  • 71 (n)
  • 67.23 (a)
MPV17L2 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MPV17L2 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mpv17l2 35
  • 62.3 (n)
  • 61.31 (a)
zebrafish
(Danio rerio)
Actinopterygii mpv17l2 35
  • 64.02 (n)
  • 64.2 (a)
mpv17l2 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001403 35
  • 50.89 (n)
  • 41.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1662 36
  • 29 (a)
OneToMany
CG32262 36
  • 27 (a)
OneToMany
CG32263 36
  • 30 (a)
OneToMany
CG5906 35
  • 50.48 (n)
  • 41.62 (a)
CG5906 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZK470.1 35
  • 47.71 (n)
  • 36.87 (a)
ZK470.1 36
  • 31 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SYM1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToOne
Species with no ortholog for MPV17L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPV17L2 Gene

ENSEMBL:
Gene Tree for MPV17L2 (if available)
TreeFam:
Gene Tree for MPV17L2 (if available)

Paralogs for MPV17L2 Gene

Paralogs for MPV17L2 Gene

Selected SIMAP similar genes for MPV17L2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MPV17L2 Gene

genes like me logo Genes that share paralogs with MPV17L2: view

Variants for MPV17L2 Gene

Sequence variations from dbSNP and Humsavar for MPV17L2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs874628 - 18,193,890(-) ACCCA(C/T)GCTGC reference, missense
rs968727 -- 18,193,940(+) TTCCC(C/T)GCGTC synonymous-codon, reference
rs1044821 -- 18,196,298(+) TCATG(C/T)GACCT utr-variant-3-prime
rs2271881 -- 18,195,014(+) CCCCC(C/T)CAATT reference, synonymous-codon
rs4808761 -- 18,191,305(+) gcggg(A/C)acctg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MPV17L2 Gene

Variant ID Type Subtype PubMed ID
dgv3771n71 CNV Loss 21882294
nsv911244 CNV Gain 21882294
dgv3773n71 CNV Loss 21882294
nsv833775 CNV Loss 17160897
dgv3774n71 CNV Loss 21882294
nsv911254 CNV Loss 21882294
nsv911256 CNV Loss 21882294
nsv911260 CNV Loss 21882294
dgv3777n71 CNV Gain 21882294
dgv576n67 CNV Gain 20364138
nsv819691 CNV Gain 19587683

Relevant External Links for MPV17L2 Gene

HapMap Linkage Disequilibrium report
MPV17L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPV17L2 Gene

Disorders for MPV17L2 Gene

Relevant External Links for MPV17L2

Genetic Association Database (GAD)
MPV17L2
Human Genome Epidemiology (HuGE) Navigator
MPV17L2
genes like me logo Genes that share disorders with MPV17L2: view

No data available for UniProtKB/Swiss-Prot for MPV17L2 Gene

Publications for MPV17L2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3 48
  4. MPV17L2 is required for ribosome assembly in mitochondria. (PMID: 24948607) Dalla Rosa I. … Spinazzola A. (Nucleic Acids Res. 2014) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for MPV17L2 Gene

  • antibodies-online proteins for MPV17L2
  • antibodies-online antibodies for MPV17L2
  • antibodies-online kits for MPV17L2

Sources for MPV17L2 Gene

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