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Aliases for MPV17L2 Gene

Aliases for MPV17L2 Gene

  • MPV17 Mitochondrial Membrane Protein-Like 2 2 3
  • FKSG24 3 4
  • Mpv17-Like Protein 2 3

External Ids for MPV17L2 Gene

Previous GeneCards Identifiers for MPV17L2 Gene

  • GC19P018167
  • GC19P018304
  • GC19P017867
  • GC19P018421

Summaries for MPV17L2 Gene

GeneCards Summary for MPV17L2 Gene

MPV17L2 (MPV17 Mitochondrial Membrane Protein-Like 2) is a Protein Coding gene. Among its related pathways are Peroxisome. An important paralog of this gene is MPV17.

UniProtKB/Swiss-Prot for MPV17L2 Gene

  • Required for the assembly and stability of the mitochondrial ribosome (PubMed:24948607). Is a positive regulator of mitochondrial protein synthesis (PubMed:24948607).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPV17L2 Gene

Genomics for MPV17L2 Gene

Regulatory Elements for MPV17L2 Gene

Genomic Location for MPV17L2 Gene

18,193,182 bp from pter
18,196,948 bp from pter
3,767 bases
Plus strand

Genomic View for MPV17L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPV17L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPV17L2 Gene

Proteins for MPV17L2 Gene

  • Protein details for MPV17L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mpv17-like protein 2
    Protein Accession:
    Secondary Accessions:
    • Q96P34
    • Q96QA0
    • Q9BSG4

    Protein attributes for MPV17L2 Gene

    206 amino acids
    Molecular mass:
    23180 Da
    Quaternary structure:
    • Interacts with the large mitochondrial ribosomal subunit.

    Alternative splice isoforms for MPV17L2 Gene


neXtProt entry for MPV17L2 Gene

Proteomics data for MPV17L2 Gene at MOPED

Post-translational modifications for MPV17L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MPV17L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MPV17L2 Gene

Domains for MPV17L2 Gene

Protein Domains for MPV17L2 Gene


Suggested Antigen Peptide Sequences for MPV17L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peroxisomal membrane protein PXMP2/4 family.
  • Belongs to the peroxisomal membrane protein PXMP2/4 family.
genes like me logo Genes that share domains with MPV17L2: view

No data available for Gene Families for MPV17L2 Gene

Function for MPV17L2 Gene

Molecular function for MPV17L2 Gene

UniProtKB/Swiss-Prot Function:
Required for the assembly and stability of the mitochondrial ribosome (PubMed:24948607). Is a positive regulator of mitochondrial protein synthesis (PubMed:24948607).

Phenotypes for MPV17L2 Gene

GenomeRNAi human phenotypes for MPV17L2:
genes like me logo Genes that share phenotypes with MPV17L2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPV17L2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MPV17L2 Gene

Localization for MPV17L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPV17L2 Gene

Membrane; Multi-pass membrane protein. Mitochondrion inner membrane.

Subcellular locations from

Jensen Localization Image for MPV17L2 Gene COMPARTMENTS Subcellular localization image for MPV17L2 gene
Compartment Confidence
mitochondrion 3
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MPV17L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IDA 24948607
GO:0005762 mitochondrial large ribosomal subunit IDA 24948607
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MPV17L2: view

Pathways for MPV17L2 Gene

SuperPathways for MPV17L2 Gene

Superpath Contained pathways
1 Peroxisome
genes like me logo Genes that share pathways with MPV17L2: view

Pathways by source for MPV17L2 Gene

1 KEGG pathway for MPV17L2 Gene

Interacting Proteins for MPV17L2 Gene

Gene Ontology (GO) - Biological Process for MPV17L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061668 mitochondrial ribosome assembly IMP 24948607
GO:0070131 positive regulation of mitochondrial translation IMP 24948607
genes like me logo Genes that share ontologies with MPV17L2: view

Transcripts for MPV17L2 Gene

mRNA/cDNA for MPV17L2 Gene

Unigene Clusters for MPV17L2 Gene

MPV17 mitochondrial membrane protein-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPV17L2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPV17L2 Gene

No ASD Table

Relevant External Links for MPV17L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPV17L2 Gene

mRNA expression in normal human tissues for MPV17L2 Gene

Protein differential expression in normal tissues for MPV17L2 Gene

This gene is overexpressed in Serum (26.7), Lung (18.3), and Bone (9.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MPV17L2 Gene

SOURCE GeneReport for Unigene cluster for MPV17L2 Gene Hs.515254

genes like me logo Genes that share expressions with MPV17L2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for MPV17L2 Gene

Orthologs for MPV17L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MPV17L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MPV17L2 35
  • 85.71 (n)
  • 87.19 (a)
MPV17L2 36
  • 81 (a)
(Canis familiaris)
Mammalia MPV17L2 35
  • 84.93 (n)
  • 86.7 (a)
MPV17L2 36
  • 79 (a)
(Mus musculus)
Mammalia Mpv17l2 35
  • 79.4 (n)
  • 79.9 (a)
Mpv17l2 16
Mpv17l2 36
  • 80 (a)
(Pan troglodytes)
Mammalia MPV17L2 35
  • 99.84 (n)
  • 100 (a)
MPV17L2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mpv17l2 35
  • 78.56 (n)
  • 79.4 (a)
(Monodelphis domestica)
Mammalia MPV17L2 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia MPV17L2 36
  • 64 (a)
(Gallus gallus)
Aves MPV17L2 35
  • 71 (n)
  • 67.23 (a)
MPV17L2 36
  • 56 (a)
(Anolis carolinensis)
Reptilia MPV17L2 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mpv17l2 35
  • 62.3 (n)
  • 61.31 (a)
(Danio rerio)
Actinopterygii mpv17l2 35
  • 64.02 (n)
  • 64.2 (a)
mpv17l2 36
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001403 35
  • 50.89 (n)
  • 41.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5906 35
  • 50.48 (n)
  • 41.62 (a)
CG1662 36
  • 29 (a)
CG32262 36
  • 27 (a)
CG32263 36
  • 30 (a)
CG5906 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea ZK470.1 35
  • 47.71 (n)
  • 36.87 (a)
ZK470.1 36
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SYM1 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for MPV17L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPV17L2 Gene

Gene Tree for MPV17L2 (if available)
Gene Tree for MPV17L2 (if available)

Paralogs for MPV17L2 Gene

Paralogs for MPV17L2 Gene

(1) SIMAP similar genes for MPV17L2 Gene using alignment to 1 proteins: Pseudogenes for MPV17L2 Gene

genes like me logo Genes that share paralogs with MPV17L2: view

Variants for MPV17L2 Gene

Sequence variations from dbSNP and Humsavar for MPV17L2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs874628 - 18,193,890(-) ACCCA(C/T)GCTGC reference, missense
rs578108722 -- 18,196,097(+) CTGGC(C/G)GACCA utr-variant-3-prime
rs578044178 -- 18,195,371(+) GAAAC(C/T)CCTTC intron-variant
rs576744548 -- 18,193,807(+) GAGAG(C/G)GAATG intron-variant
rs576199741 -- 18,192,519(+) GGCCC(A/G)TGCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MPV17L2 Gene

Variant ID Type Subtype PubMed ID
dgv3771n71 CNV Loss 21882294
nsv911244 CNV Gain 21882294
dgv3773n71 CNV Loss 21882294
nsv833775 CNV Loss 17160897
dgv3774n71 CNV Loss 21882294
nsv911254 CNV Loss 21882294
nsv911256 CNV Loss 21882294
nsv911260 CNV Loss 21882294
dgv3777n71 CNV Gain 21882294
dgv576n67 CNV Gain 20364138
nsv819691 CNV Gain 19587683

Relevant External Links for MPV17L2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPV17L2 Gene

Disorders for MPV17L2 Gene

Relevant External Links for MPV17L2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MPV17L2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MPV17L2 Gene

Publications for MPV17L2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3 48
  4. MPV17L2 is required for ribosome assembly in mitochondria. (PMID: 24948607) Dalla Rosa I. … Spinazzola A. (Nucleic Acids Res. 2014) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for MPV17L2 Gene

Sources for MPV17L2 Gene

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