MPV17L2 Gene
protein-coding GIFtS: 43
GCID: GC19P018304
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MPV17 mitochondrial membrane protein-like 2
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Aliases
for MPV17L2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MPV17 Mitochondrial Membrane Protein-Like 21 2 | | FKSG241 2 3 | | MGC129721 | | Mpv17-Like Protein 22 |
Export aliases for MPV17L2 gene to outside databasesPrevious GC identifers: GC19P018167 GC19P017867 |
Summaries
for MPV17L2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MPV17L2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MPV17L2 gene promoter:
Pax-5 Pax-2 Pax-2a Roaz MEF-2A FOXC1 HOXA5 HSF2 aMEF-2 TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for MPV17L2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPV17L2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.11MPV17L2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P018304: view genomic region
(about GC identifiers)
Start:
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18,304,028 bp from pter |
End:
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18,307,552 bp from pter |
Size:
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3,525 bases |
Orientation:
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plus strand |
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Proteins
for MPV17L2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: M17L2_HUMAN, Q567V2 (See
protein sequence)Recommended Name: Mpv17-like protein 2 Size: 206 amino acids; 23180 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q96P34 Q96QA0 Q9BSG4Alternative splicing: 2 isoforms: Q567V2-1 Q567V2-2 Explore the universe of human proteins at neXtProt for MPV17L2: NX_Q567V2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q567V2
MPV17L2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_116072.2
ENSEMBL proteins: ENSP00000435162 ENSP00000247712
Human Recombinant Protein Products for MPV17L2:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
MPV17L2 for ontologies About GeneDecksing
MPV17L2 Antibody Products:
Assay Products for MPV17L2: |
Protein
Domains /
Families
for MPV17L2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MPV17L2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q567V2ProtoNet protein and cluster: Q567V2 1 Blocks protein family: IPB007248 Mpv17/PMP22
UniProtKB/Swiss-Prot: M17L2_HUMAN, Q567V2Similarity: Belongs to the peroxisomal membrane protein PXMP2/4 family |
Function
for MPV17L2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for MPV17L2:
1 MGI phenotypic allele  for Mpv17l2 (no phenotypes)
MPV17L2 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Mpv17l2tm1Lex for MPV17L2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPV17L2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPV17L2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for MPV17L2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPV17L2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPV17L2 |
|
Pathways & Interactions
for MPV17L2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MPV17L2
|
Drugs & Compounds
for MPV17L2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MPV17L2
Search CenterWatch for drugs/clinical trials and news about MPV17L2 / M17L2
|
Transcripts
for MPV17L2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MPV17L2 gene: NM_032683.2 Unigene Cluster for MPV17L2: MPV17 mitochondrial membrane protein-like 2 Hs.515254 [show with all ESTs]Unigene Representative Sequence: BC0281465 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000534421 ENST00000534474 ENST00000533807 ENST00000532896(uc010ebj.3)
ENST00000247712(uc002nid.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPV17L2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPV17L2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MPV17L2 (NM_032683) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MPV17L2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPV17L2 |
Additional cDNA sequence: AF320622.1 AF416712.1 AK094091.1 BC005064.1 BC028146.1 BC093008.1 5 DOTS entries: DT.412098 DT.121450326 DT.100653326 DT.100815373 DT.102830238 24/100 AceView cDNA sequences (see all 100): CA389829 H41027 AI498944 BQ684293 BC005064 AK094091 AI825828 AA554683 BG740168 NM_032683 AA380652 CD367497 BU633323 BM974561 CR623978 CB160305 CB115590 AF320622 AI697543 AI090282 BF791879 AW438677 BX115784 AF416712
GeneLoc Exon Structure
|
Expression
for MPV17L2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MPV17L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGATCCCC
About this image
See MPV17L2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MPV17L2
SOURCE GeneReport for Unigene cluster: Hs.515254
SABiosciences Custom PCR Arrays for MPV17L2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPV17L2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MPV17L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPV17L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPV17L2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPV17L2 |
Orthologs
for MPV17L2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MPV17L2 gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for MPV17L2 (if available)
TreeFam Gene Tree for MPV17L2 (if available) |
Paralogs
for MPV17L2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MPV17L2 gene
- PXMP22 ENSG000002611302 MPV172 MPV17L2
1 SIMAP similar gene for MPV17L2 using alignment to 2 protein entries: M17L2_HUMAN (see all proteins):MPV17
MPV17L2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MPV17L2
PGOHUM00000241785
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Genomic Variants
for MPV17L2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MPV17L2 (18304028 - 18307552 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MPV17L2
2 CNVs: 5093 58863 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MPV17L2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MPV17L2 for disorders About MalaCards
MPV17L2 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: MPV17L2 (1 document)
Export disorders for MPV17L2 gene to outside databases
|
Publications
for MPV17L2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MPV17L2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MPV17L2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1 ....Compston A. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for MPV17L2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MPV17L2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MPV17L2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MPV17L2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MPV17L2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MPV17L2 gene:
Search GeneIP for patents involving MPV17L2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MPV17L2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MPV17L2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPV17L2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPV17L2 | | | OriGene Protein Over-expression Lysate for MPV17L2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MPV17L2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPV17L2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPV17L2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MPV17L2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MPV17L2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPV17L2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPV17L2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPV17L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPV17L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPV17L2 |
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 | | | MPV17L2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPV17L2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPV17L2 |
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