MPV17L Gene
protein-coding GIFtS: 47
GCID: GC16P015398
|
|
MPV17 mitochondrial membrane protein-like
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Aliases
for MPV17L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MPV17 Mitochondrial Membrane Protein-Like1 2 | | M-LP Homolog2 3 | | MLPH11 2 | | FLJ395991 | | MLPH21 2 | | Mpv17-Like Protein2 | | MPV17L11 2 | | Mpv17-Like Protein Type 12 | | M-LPH2 3 | | Mpv17-Like Protein Type 22 |
Export aliases for MPV17L gene to outside databasesPrevious GC identifer: GC16P014882 |
Summaries
for MPV17L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MP17L_HUMAN, Q2QL34Function: Isoform 1 participates in reactive oxygen species metablism by up- or down-regulation of the genes ofantioxidant enzymes
|
Genomic Views
for MPV17L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MPV17L gene promoter:
E2F-4 E2F-3a TBP Pax-5 E2F-2 MEF-2A E2F E2F-1 TFIID aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MPV17L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPV17L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.11 Ensembl cytogenetic band: 16p13.11 HGNC cytogenetic band: 16p13.11MPV17L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P015398: view genomic region
(about GC identifiers)
Start:
|
15,489,611 bp from pter |
End:
|
15,503,543 bp from pter |
Size:
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13,933 bases |
Orientation:
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plus strand |
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Proteins
for MPV17L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MP17L_HUMAN, Q2QL34 (See
protein sequence)Recommended Name: Mpv17-like protein Size: 196 amino acids; 22116 Da
Subcellular location: Isoform 1: Peroxisome membrane; Multi-pass membrane protein
Secondary accessions: B4DDY1 Q6P7T6 Q8N8E9Alternative splicing: 2 isoforms: Q2QL34-1 Q2QL34-2 (Ref.2 (BAC04895) sequence is in conflict in position: 106:T->I)Explore the universe of human proteins at neXtProt for MPV17L: NX_Q2QL34
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2QL34
MPV17L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001121895.1 NP_776164.2
ENSEMBL proteins: ENSP00000287594 ENSP00000379669 ENSP00000457012
Human Recombinant Protein Products for MPV17L:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MPV17L for ontologies About GeneDecksing
MPV17L Antibody Products:
Assay Products for MPV17L: |
Protein
Domains /
Families
for MPV17L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MPV17L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q2QL34ProtoNet protein and cluster: Q2QL34 1 Blocks protein family: IPB007248 Mpv17/PMP22
UniProtKB/Swiss-Prot: MP17L_HUMAN, Q2QL34Similarity: Belongs to the peroxisomal membrane protein PXMP2/4 family |
Function
for MPV17L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MP17L_HUMAN, Q2QL34Function: Isoform 1 participates in reactive oxygen species metablism by up- or down-regulation of the genes ofantioxidant enzymes Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0005102 | receptor binding |
IPI | -- |
MPV17L for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for MPV17L:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPV17L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPV17L (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for MPV17L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPV17L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPV17L |
|
Pathways & Interactions
for MPV17L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Peroxisome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for MPV17L):
MPV17L for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MPV17L
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for MPV17L (ENSP000003796694) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010730 | negative regulation of hydrogen peroxide biosynthetic process |
IDA | -- | | GO:0072593 | reactive oxygen species metabolic process |
IDA | 16631601 | | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization |
IDA | -- |
MPV17L for ontologies About GeneDecksing
|
Drugs & Compounds
for MPV17L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MPV17L
Search CenterWatch for drugs/clinical trials and news about MPV17L / MP17L
|
Transcripts
for MPV17L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MPV17L gene (2 alternative transcripts): NM_001128423.1 NM_173803.3 Unigene Cluster for MPV17L: MPV17 mitochondrial membrane protein-like Hs.720673 [show with all ESTs]Unigene Representative Sequence: NM_0011284233 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000287594(uc002ddn.2 uc002ddm.2) ENST00000396385 ENST00000564148
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPV17L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPV17L (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MPV17L (NM_032683) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MPV17L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPV17L |
Additional cDNA sequence: AK096918.1 AK293380.1 BC061514.1 DQ004255.1 DQ004256.1 5 DOTS entries: DT.97763412 DT.449066 DT.86837411 DT.91707461 DT.91720316 10 AceView cDNA sequences: NM_173803 AK096918 BG742770 AI798644 BU902267 BC061514 BX497555 AW938999 BM838624 BF813929
GeneLoc Exon Structure
|
Expression
for MPV17L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MPV17L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGGGCTGGT
About this image
See MPV17L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MPV17L
SOURCE GeneReport for Unigene cluster: Hs.720673
UniProtKB/Swiss-Prot: MP17L_HUMAN, Q2QL34Tissue specificity: Isoform 1 is detected in the kidney (at protein level). Isoform 1 and isoform 2 are expressed inthe kidney, heart, liver, lung, pancreas and skeletal muscle
SABiosciences Custom PCR Arrays for MPV17L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPV17L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MPV17L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPV17L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPV17L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPV17L |
Orthologs
for MPV17L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MPV17L gene from 5/21 species (see all 21) About this table
ENSEMBL Gene Tree for MPV17L (if available)
TreeFam Gene Tree for MPV17L (if available) |
Paralogs
for MPV17L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MPV17L gene
- PXMP22 ENSG000002611302 MPV172 MPV17L22
2 SIMAP similar genes for MPV17L using alignment to 2 protein entries: MP17L_HUMAN (see all proteins):SULT1A1 MPV17
MPV17L for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for MPV17L
PGOHUM00000249043 PGOHUM00000249046
|
Genomic Variants
for MPV17L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MPV17L (15489611 - 15503543 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MPV17L
2 CNVs: 4924 4925 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPV17L |
|
Disorders
/ Diseases
for MPV17L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MPV17L for disorders About GeneDecksing
2  diseases for MPV17L: About MalaCardsureteral obstruction kidney disease
Export disorders for MPV17L gene to outside databases
|
Publications
for MPV17L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MPV17L gene integrated from 9 sources:
(articles sorted by number of sources associating them with MPV17L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes. (PubMed id 16631601)1, 2, 3 Iida R.... Kishi K. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for MPV17L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MPV17L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MPV17L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MPV17L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MPV17L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MPV17L gene:
Search GeneIP for patents involving MPV17L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MPV17L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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 | | | MPV17L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPV17L |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPV17L |
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