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Aliases for MPV17L Gene

Aliases for MPV17L Gene

  • MPV17 Mitochondrial Membrane Protein-Like 2 3
  • M-LP Homolog 3 4
  • M-LPH 3 4
  • Mpv17-Like Protein Type 1 3
  • Mpv17-Like Protein Type 2 3
  • Mpv17-Like Protein 3
  • MPV17L1 3
  • MLPH1 3
  • MLPH2 3

External Ids for MPV17L Gene

Previous GeneCards Identifiers for MPV17L Gene

  • GC16P014882

Summaries for MPV17L Gene

GeneCards Summary for MPV17L Gene

MPV17L (MPV17 Mitochondrial Membrane Protein-Like) is a Protein Coding gene. Among its related pathways are Peroxisome. GO annotations related to this gene include receptor binding. An important paralog of this gene is ENSG00000261130.

UniProtKB/Swiss-Prot for MPV17L Gene

  • Isoform 1 participates in reactive oxygen species metablism by up- or down-regulation of the genes of antioxidant enzymes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPV17L Gene

Genomics for MPV17L Gene

Regulatory Elements for MPV17L Gene

Genomic Location for MPV17L Gene

15,395,577 bp from pter
15,413,268 bp from pter
17,692 bases
Plus strand

Genomic View for MPV17L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPV17L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPV17L Gene

Proteins for MPV17L Gene

  • Protein details for MPV17L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mpv17-like protein
    Protein Accession:
    Secondary Accessions:
    • B4DDY1
    • Q6P7T6
    • Q8N8E9

    Protein attributes for MPV17L Gene

    196 amino acids
    Molecular mass:
    22116 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MPV17L Gene


neXtProt entry for MPV17L Gene

Proteomics data for MPV17L Gene at MOPED

Post-translational modifications for MPV17L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MPV17L Gene

No data available for DME Specific Peptides for MPV17L Gene

Domains for MPV17L Gene

Protein Domains for MPV17L Gene


Suggested Antigen Peptide Sequences for MPV17L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q2QL34
  • Belongs to the peroxisomal membrane protein PXMP2/4 family.
genes like me logo Genes that share domains with MPV17L: view

No data available for Gene Families for MPV17L Gene

Function for MPV17L Gene

Molecular function for MPV17L Gene

UniProtKB/Swiss-Prot Function: Isoform 1 participates in reactive oxygen species metablism by up- or down-regulation of the genes of antioxidant enzymes.

Gene Ontology (GO) - Molecular Function for MPV17L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005102 receptor binding IPI 20178365
genes like me logo Genes that share ontologies with MPV17L: view

Phenotypes for MPV17L Gene

genes like me logo Genes that share phenotypes with MPV17L: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPV17L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MPV17L Gene

Localization for MPV17L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPV17L Gene

Isoform 1: Peroxisome membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MPV17L Gene COMPARTMENTS Subcellular localization image for MPV17L gene
Compartment Confidence
peroxisome 5
mitochondrion 2
cytosol 1
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MPV17L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IDA 16631601
GO:0005778 peroxisomal membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MPV17L: view

Pathways for MPV17L Gene

SuperPathways for MPV17L Gene

Superpath Contained pathways
1 Peroxisome
genes like me logo Genes that share pathways with MPV17L: view

Pathways by source for MPV17L Gene

1 KEGG pathway for MPV17L Gene

Interacting Proteins for MPV17L Gene

Gene Ontology (GO) - Biological Process for MPV17L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010730 negative regulation of hydrogen peroxide biosynthetic process IDA 22306510
GO:0072593 reactive oxygen species metabolic process IDA 16631601
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA 22306510
genes like me logo Genes that share ontologies with MPV17L: view

Transcripts for MPV17L Gene

mRNA/cDNA for MPV17L Gene

(10) Selected AceView cDNA sequences:
(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MPV17L Gene

MPV17 mitochondrial membrane protein-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPV17L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPV17L Gene

No ASD Table

Relevant External Links for MPV17L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPV17L Gene

mRNA expression in normal human tissues for MPV17L Gene

mRNA differential expression in normal tissues according to GTEx for MPV17L Gene

This gene is overexpressed in Pancreas (5.2) and Muscle - Skeletal (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPV17L Gene

SOURCE GeneReport for Unigene cluster for MPV17L Gene Hs.720673

mRNA Expression by UniProt/SwissProt for MPV17L Gene

Tissue specificity: Isoform 1 is detected in the kidney (at protein level). Isoform 1 and isoform 2 are expressed in the kidney, heart, liver, lung, pancreas and skeletal muscle.
genes like me logo Genes that share expressions with MPV17L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MPV17L Gene

Orthologs for MPV17L Gene

This gene was present in the common ancestor of animals.

Orthologs for MPV17L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 98 (a)
-- 36
  • 98 (a)
-- 36
  • 98 (a)
-- 36
  • 98 (a)
(Bos Taurus)
Mammalia -- 36
  • 70 (a)
MPV17L 35
  • 78.23 (n)
  • 69.9 (a)
(Canis familiaris)
Mammalia -- 36
  • 53 (a)
(Mus musculus)
Mammalia Mpv17l 35
  • 79.04 (n)
  • 78.35 (a)
Mpv17l 16
Mpv17l 36
  • 78 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
(Rattus norvegicus)
Mammalia LOC100362572 35
  • 78.87 (n)
  • 77.32 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493944 35
  • 56.39 (n)
  • 50.94 (a)
(Danio rerio)
Actinopterygii LOC563178 35
  • 56.77 (n)
  • 52.12 (a)
MPV17L 36
  • 29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012390 35
  • 44.44 (n)
  • 30.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12355 35
  • 43.95 (n)
  • 35.67 (a)
CG12355 36
  • 29 (a)
CG14777 36
  • 27 (a)
CG14778 36
  • 23 (a)
CG2022 36
  • 21 (a)
Species with no ortholog for MPV17L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPV17L Gene

Gene Tree for MPV17L (if available)
Gene Tree for MPV17L (if available)

Paralogs for MPV17L Gene

Paralogs for MPV17L Gene

Selected SIMAP similar genes for MPV17L Gene using alignment to 2 proteins: Pseudogenes for MPV17L Gene

genes like me logo Genes that share paralogs with MPV17L: view

Variants for MPV17L Gene

Structural Variations from Database of Genomic Variants (DGV) for MPV17L Gene

Variant ID Type Subtype PubMed ID
nsv833145 CNV Gain 17160897
nsv435664 CNV Deletion 17901297
nsv905385 CNV Gain 21882294
esv2714015 CNV Deletion 23290073
nsv833146 CNV Gain 17160897
nsv905386 CNV Gain 21882294
dgv2610n71 CNV Gain 21882294
nsv457428 CNV Gain 19166990
nsv1741 CNV Insertion 18451855
esv2664596 CNV Deletion 23128226

Relevant External Links for MPV17L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MPV17L Gene

Disorders for MPV17L Gene

No disorders were found for MPV17L Gene.

No data available for UniProtKB/Swiss-Prot for MPV17L Gene

Publications for MPV17L Gene

  1. Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes. (PMID: 16631601) Iida R. … Kishi K. (Biochem. Biophys. Res. Commun. 2006) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for MPV17L Gene

  • antibodies-online peptides for MPV17L
  • antibodies-online antibodies for MPV17L
  • antibodies-online kits for MPV17L

Sources for MPV17L Gene

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