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Aliases for MPV17L Gene

Aliases for MPV17L Gene

  • MPV17 Mitochondrial Inner Membrane Protein Like 2 3 5
  • M-LP Homolog 3 4
  • M-LPH 3 4
  • MPV17 Mitochondrial Membrane Protein-Like 3
  • Mpv17-Like Protein Type 1 3
  • Mpv17-Like Protein Type 2 3
  • Mpv17-Like Protein 3
  • MPV17L1 3
  • MLPH1 3
  • MLPH2 3

External Ids for MPV17L Gene

Previous GeneCards Identifiers for MPV17L Gene

  • GC16P014882

Summaries for MPV17L Gene

GeneCards Summary for MPV17L Gene

MPV17L (MPV17 Mitochondrial Inner Membrane Protein Like) is a Protein Coding gene. Among its related pathways are Peroxisome. GO annotations related to this gene include receptor binding. An important paralog of this gene is ENSG00000261130.

UniProtKB/Swiss-Prot for MPV17L Gene

  • Isoform 1 participates in reactive oxygen species metablism by up- or down-regulation of the genes of antioxidant enzymes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPV17L Gene

Genomics for MPV17L Gene

Regulatory Elements for MPV17L Gene

Enhancers for MPV17L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F015403 1.6 FANTOM5 Ensembl ENCODE 29.7 +8.9 8890 2.0 ZNF384 YBX1 PLRG1 RARA ZNF155 ZKSCAN1 ZNF335 GATA3 POLR2A ZNF366 MPV17L RRN3 LOC100505915 PKD1P1 ENSG00000183458 PKD1P6 ENSG00000261130 GC16P015412
GH16F015414 0.6 ENCODE 26 +19.6 19577 1.1 GTF2F1 ATF1 ZMYM3 ZIC2 ZNF664 GATA3 FOS MAZ ZNF740 BHLHE40 MPV17L RRN3 NPIPA2 GC16P015412 C16orf45
GH16F015395 0.7 ENCODE 23.8 +1.9 1882 4.0 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS SP5 NFYC MPV17L PDXDC1 LOC100505915 ENSG00000261130 GC16P015412
GH16F015427 1.1 Ensembl ENCODE 21.9 +32.2 32236 0.7 HDGF ATF1 PKNOX1 ARNT ARID4B SIN3A ZNF121 ZNF766 GATA2 ZNF143 MPV17L C16orf45 GC16P015412
GH16F015382 0.2 Ensembl 19.2 -12.8 -12797 1.0 EGR2 MPV17L NPIPA5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MPV17L on UCSC Golden Path with GeneCards custom track

Promoters for MPV17L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000504337 502 1600 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 FOS SP5

Genomic Location for MPV17L Gene

Chromosome:
16
Start:
15,395,698 bp from pter
End:
15,413,268 bp from pter
Size:
17,571 bases
Orientation:
Plus strand

Genomic View for MPV17L Gene

Genes around MPV17L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPV17L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPV17L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPV17L Gene

Proteins for MPV17L Gene

  • Protein details for MPV17L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2QL34-MP17L_HUMAN
    Recommended name:
    Mpv17-like protein
    Protein Accession:
    Q2QL34
    Secondary Accessions:
    • B4DDY1
    • Q6P7T6
    • Q8N8E9

    Protein attributes for MPV17L Gene

    Size:
    196 amino acids
    Molecular mass:
    22116 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MPV17L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPV17L Gene

Post-translational modifications for MPV17L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MPV17L Gene

No data available for DME Specific Peptides for MPV17L Gene

Domains & Families for MPV17L Gene

Protein Domains for MPV17L Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MPV17L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2QL34

UniProtKB/Swiss-Prot:

MP17L_HUMAN :
  • Belongs to the peroxisomal membrane protein PXMP2/4 family.
Family:
  • Belongs to the peroxisomal membrane protein PXMP2/4 family.
genes like me logo Genes that share domains with MPV17L: view

No data available for Gene Families for MPV17L Gene

Function for MPV17L Gene

Molecular function for MPV17L Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 participates in reactive oxygen species metablism by up- or down-regulation of the genes of antioxidant enzymes.

Gene Ontology (GO) - Molecular Function for MPV17L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005102 receptor binding IPI 20178365
genes like me logo Genes that share ontologies with MPV17L: view
genes like me logo Genes that share phenotypes with MPV17L: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPV17L Gene

Localization for MPV17L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPV17L Gene

Isoform 1: Peroxisome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MPV17L Gene COMPARTMENTS Subcellular localization image for MPV17L gene
Compartment Confidence
mitochondrion 5
peroxisome 5
cytosol 1
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MPV17L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome IEA --
GO:0005778 peroxisomal membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MPV17L: view

Pathways & Interactions for MPV17L Gene

SuperPathways for MPV17L Gene

SuperPathway Contained pathways
1 Peroxisome
genes like me logo Genes that share pathways with MPV17L: view

Pathways by source for MPV17L Gene

1 KEGG pathway for MPV17L Gene

Interacting Proteins for MPV17L Gene

Gene Ontology (GO) - Biological Process for MPV17L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010730 negative regulation of hydrogen peroxide biosynthetic process IDA 22306510
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA 22306510
genes like me logo Genes that share ontologies with MPV17L: view

No data available for SIGNOR curated interactions for MPV17L Gene

Transcripts for MPV17L Gene

mRNA/cDNA for MPV17L Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MPV17L Gene

MPV17 mitochondrial membrane protein-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPV17L Gene

No ASD Table

Relevant External Links for MPV17L Gene

GeneLoc Exon Structure for
MPV17L
ECgene alternative splicing isoforms for
MPV17L

Expression for MPV17L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MPV17L Gene

mRNA differential expression in normal tissues according to GTEx for MPV17L Gene

This gene is overexpressed in Pancreas (x5.2) and Muscle - Skeletal (x4.2).

Protein differential expression in normal tissues from HIPED for MPV17L Gene

This gene is overexpressed in Kidney (55.5) and Islet of Langerhans (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MPV17L Gene



Protein tissue co-expression partners for MPV17L Gene

NURSA nuclear receptor signaling pathways regulating expression of MPV17L Gene:

MPV17L

SOURCE GeneReport for Unigene cluster for MPV17L Gene:

Hs.720673

mRNA Expression by UniProt/SwissProt for MPV17L Gene:

Q2QL34-MP17L_HUMAN
Tissue specificity: Isoform 1 is detected in the kidney (at protein level). Isoform 1 and isoform 2 are expressed in the kidney, heart, liver, lung, pancreas and skeletal muscle.
genes like me logo Genes that share expression patterns with MPV17L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MPV17L Gene

Orthologs for MPV17L Gene

This gene was present in the common ancestor of animals.

Orthologs for MPV17L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 98 (a)
OneToMany
-- 35
  • 98 (a)
OneToMany
-- 35
  • 98 (a)
OneToMany
-- 35
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mpv17l 34 16 35
  • 79.04 (n)
rat
(Rattus norvegicus)
Mammalia LOC100362572 34
  • 78.87 (n)
cow
(Bos Taurus)
Mammalia MPV17L 34
  • 78.23 (n)
-- 35
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 39 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493944 34
  • 56.39 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC563178 34
  • 56.77 (n)
MPV17L 35
  • 29 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012390 34
  • 44.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12355 34 35
  • 43.95 (n)
CG14777 35
  • 27 (a)
ManyToMany
CG14778 35
  • 23 (a)
ManyToMany
CG2022 35
  • 21 (a)
ManyToMany
Species where no ortholog for MPV17L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPV17L Gene

ENSEMBL:
Gene Tree for MPV17L (if available)
TreeFam:
Gene Tree for MPV17L (if available)

Paralogs for MPV17L Gene

Paralogs for MPV17L Gene

(2) SIMAP similar genes for MPV17L Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MPV17L Gene

genes like me logo Genes that share paralogs with MPV17L: view

Variants for MPV17L Gene

Sequence variations from dbSNP and Humsavar for MPV17L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11075264 -- 15,399,729(+) GTAGT(C/T)GCCAG intron-variant, downstream-variant-500B
rs111403724 -- 15,394,598(+) TCCTG(C/G)GTTCA upstream-variant-2KB
rs111659587 -- 15,407,890(+) AGGGC(C/T)TTGGT intron-variant
rs112299883 -- 15,395,631(+) GTTCT(C/G)GGTAT upstream-variant-2KB, utr-variant-5-prime
rs112954053 -- 15,404,838(+) ACAAA(C/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPV17L Gene

Variant ID Type Subtype PubMed ID
dgv2755n100 CNV gain 25217958
dgv4924n54 CNV gain 21841781
esv2664596 CNV deletion 23128226
esv2714015 CNV deletion 23290073
esv3638030 CNV loss 21293372
nsv1035393 CNV gain 25217958
nsv1038151 CNV loss 25217958
nsv1040547 CNV gain 25217958
nsv1045440 CNV gain 25217958
nsv1047898 CNV loss 25217958
nsv1049647 CNV gain+loss 25217958
nsv1125134 CNV deletion 24896259
nsv1127473 CNV deletion 24896259
nsv1741 CNV insertion 18451855
nsv435664 CNV deletion 17901297
nsv457428 CNV gain 19166990
nsv833145 CNV gain 17160897
nsv833146 CNV gain 17160897
nsv974763 CNV duplication 23825009
nsv977121 CNV duplication 23825009

Variation tolerance for MPV17L Gene

Gene Damage Index Score: 0.03; 0.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPV17L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MPV17L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPV17L Gene

Disorders for MPV17L Gene

Relevant External Links for MPV17L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MPV17L

No disorders were found for MPV17L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPV17L Gene

Publications for MPV17L Gene

  1. Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes. (PMID: 16631601) Iida R. … Kishi K. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Identification of interacting partners of Human Mpv17-like protein with a mitigating effect of mitochondrial dysfunction through mtDNA damage. (PMID: 26165189) Iida R. … Yasuda T. (Free Radic. Biol. Med. 2015) 3 64
  4. Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP. (PMID: 22306510) Iida R. … Yasuda T. (Free Radic. Biol. Med. 2012) 3 64
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64

Products for MPV17L Gene

Sources for MPV17L Gene

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