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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MPST Gene

protein-coding   GIFtS: 60
GCID: GC22P037415

mercaptopyruvate sulfurtransferase
 Explore 8 diseases affiliated with
MPST via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MPST    

Aliases
for MPST gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mercaptopyruvate Sulfurtransferase1 2
MST1 2 3
TST21 2 3
3-Mercaptopyruvate Sulfurtransferase2
Human Liver Rhodanese2
EC 2.8.1.23

External Ids:    HGNC: 72231   Entrez Gene: 43572   Ensembl: ENSG000001283097   OMIM: 6024965   UniProtKB: P253253   
ORGUL members:         
NONCODE:n406526    

Export aliases for MPST gene to outside databases

Previous GC identifers: GC22P034030 GC22P035658 GC22P035740 GC22P020380


Summaries
for MPST gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MPST:
This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other
thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in
literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and
thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST
activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU).
Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: THTM_HUMAN, P25325
Function: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. May have a
role in cyanide degradation or in thiosulfate biosynthesis

Gene Wiki entry for MPST


Genomic Views
for MPST gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MPST gene promoter:
         RFX1   USF1   AML1a   HNF-4alpha2   HNF-4alpha1   POU2F1   POU2F1a   USF-1   ZID   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MPST promoter sequence
   Search SABiosciences Chromatin IP Primers for MPST

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPST


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q13.1

MPST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPST gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P037415:  view genomic region     (about GC identifiers)

Start:
 37,415,676 bp from pter      End:
 37,425,863 bp from pter
Size:
 10,188 bases      Orientation:
 plus strand

Proteins
for MPST gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: THTM_HUMAN, P25325 (See protein sequence)
Recommended Name: 3-mercaptopyruvate sulfurtransferase  
Size: 297 amino acids; 33178 Da
Subunit: Monomer or disulfide-linked homodimer (By similarity)
Subcellular location: Cytoplasm
Caution: Was originally (PubMed:1953758) thought to be rhodanese
1 PDB 3D structure from and Proteopedia for MPST:
3OLH (3D)    
Secondary accessions: O75750

Explore the universe of human proteins at neXtProt for MPST: NX_P25325

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P25325

    • MPST Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001013454.1  NP_001123989.1  NP_066949.2  

    ENSEMBL proteins: 
     ENSP00000384812   ENSP00000383950   ENSP00000342333   ENSP00000411719   ENSP00000385062  
     ENSP00000380402   ENSP00000380318  

    Human Recombinant Protein Products: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 4): MPST
    OriGene Protein Over-expression Lysate (see all 5): MPST
    OriGene Custom Protein Services for MPST 
    GenScript Custom Purified and Recombinant Proteins Services for MPST
    Novus Biologicals MPST Proteins
    Novus Biologicals MPST Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MPST

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane ----


    MPST for ontologies           About GeneDecksing



    MPST Antibody Products: 
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    Abcam antibodies for MPST 
    Uscn Antibodies for MPST
    Search ThermoFisher Antibodies for MPST

    Assay Products for MPST: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for MPST

    Protein Domains /
    Families
    for MPST gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MPST for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001763 Rhodanese-like_dom
     IPR001307 Thiosulphate_STrfase_CS

    Graphical View of Domain Structure for InterPro Entry P25325

    ProtoNet protein and cluster: P25325

    2 Blocks protein families:
    IPB001307 Thiosulfate sulfurtransferase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: THTM_HUMAN, P25325
    Domain: The structure consists of 2 domains of very similar conformation, suggesting a common evolutionary origin.
    However, the sequences of the 2 domains are very different
    Similarity: Contains 2 rhodanese domains


    Function
    for MPST gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: THTM_HUMAN, P25325
    Function: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. May have a
    role in cyanide degradation or in thiosulfate biosynthesis
    Catalytic activity: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate

         Genatlas biochemistry entry for MPST:
    mercaptopyruvate sulfurtransferase

    Enzyme Number (IUBMB): EC 2.8.1.21

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): MPST
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPST
    1 QIAGEN miScript miRNA Assays for microRNA that regulate MPST:
    hsa-miR-3065-3p
    SwitchGear 3'UTR luciferase reporter plasmid: MPST 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPST (see all 7)
    OriGene shRNA RFP: MPST
    OriGene siRNA: MPST
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPST

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MPST

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPST (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPST (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): MPST (NM_001013436)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPST 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MPST
    Search LifeMap BioReagents cell lines for MPST

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPST

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004792thiosulfate sulfurtransferase activity IEA--
    GO:00167843-mercaptopyruvate sulfurtransferase activity IEA--


    MPST for ontologies           About GeneDecksing



    Pathways & Interactions
    for MPST gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1L-cysteine degradation III
    		L-cysteine degradation III1.00
    2Metabolism
    		Metabolic pathways0.38
    3Sulfur amino acid metabolism
    		Cysteine and methionine metabolism0.36
    4Molybdenum cofactor biosynthesis
    		Sulfur relay system0.33

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for MPST 
        L-cysteine degradation III


    3         Kegg Pathways  (Kegg details for MPST):
        Cysteine and methionine metabolism
    Metabolic pathways
    Sulfur relay system


    MPST for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MPST

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/27 Interacting proteins for MPST (P253253 ENSP000003803184) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHMP243863, ENSP000003503864I2D: score=1 STRING: ENSP00000350386
    MOCS3O953963, ENSP000002440514I2D: score=1 STRING: ENSP00000244051
    NFS1Q9Y6973, ENSP000003632054I2D: score=1 STRING: ENSP00000363205
    RAE1P784063, ENSP000003602864I2D: score=1 STRING: ENSP00000360286
    MARCH6O603373I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009440cyanate catabolic process TAS9070219
    GO:0009636response to toxin TAS9070219


    MPST for ontologies           About GeneDecksing



    Drugs & Compounds
    for MPST gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MPST for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MPST

    8 HMDB Compounds for MPST    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Mercaptolactate-cysteine disulfide3-((2-carboxy-2-hydroxyethyl)dithio)-L-Alanine (see all 4)18841-42-4--
    3-Mercaptopyruvic acid3-Mercaptopyruvate (see all 13)2464-23-5--
    CyanideCarbon nitride ion (see all 9)57-12-5--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--
    SulfiteSulfite ion (see all 10)14265-45-3--
    ThiocyanateAmmonium rhodanate (see all 15)302-04-5--
    ThiosulfateHyposulfite (see all 14)14383-50-7--
    7 Novoseek chemical compound relationships for MPST gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    3-mercaptopyruvate 98.9 45 12871026 (4), 16719781 (4), 8806051 (3), 8934630 (2) (see all 18)
    thiosulfate 75.6 3 16500920 (1), 12871026 (1)
    thiocyanate 67.3 2 8934630 (1), 12871026 (1)
    cyanide 67.3 17 12871026 (4), 8806051 (2), 16719781 (2), 16545926 (2) (see all 5)
    sulfur 49.5 5 8934630 (1), 8806051 (1), 18781374 (1)
    cysteine 46.8 11 16719781 (3), 18537713 (2), 15329822 (1), 16545926 (1) (see all 5)
    pyruvate 41 4 2178324 (2), 16719781 (1)

    Search CenterWatch for drugs/clinical trials and news about MPST / THTM 

    Transcripts
    for MPST gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MPST gene (4 alternative transcripts): 
    NM_001013436.2  NM_001130517.2  NM_021126.5  NM_001013440.1  

    Unigene Cluster for MPST:

    Mercaptopyruvate sulfurtransferase
    Hs.248267  [show with all ESTs]
    Unigene Representative Sequence: AK055733
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000401419 ENST00000404802(uc003aqm.3) ENST00000341116(uc003aqj.3)
    ENST00000429360 ENST00000404393 ENST00000485587(uc003aqi.1) ENST00000397225
    ENST00000397129(uc003aql.3 uc011amu.2)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): MPST
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPST
    1 QIAGEN miScript miRNA Assays for microRNA that regulate MPST:
    hsa-miR-3065-3p
    SwitchGear 3'UTR luciferase reporter plasmid: MPST 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPST (see all 7)
    OriGene shRNA RFP: MPST
    OriGene siRNA: MPST
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPST
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPST (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPST (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): MPST (NM_001013436)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPST 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPST
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MPST
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPST
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPST

    Additional cDNA sequence: 

    AK055733.1 BC003508.1 BC009450.1 BC016737.1 BC018717.1 BT019636.1 CR456523.1 CR541712.1 
    X59434.1 

    19 DOTS entries:

    DT.454458  DT.100878103  DT.100878114  DT.100878090  DT.100878107  DT.100878094  DT.95141890  DT.100028399 
    DT.95141915  DT.95228409  DT.100832179  DT.100878116  DT.95141919  DT.100699933  DT.100757695  DT.100769726 
    DT.100878085  DT.100878089  DT.95141928 

    24/346 AceView cDNA sequences (see all 346):

    CR614224 CR619501 BQ941503 BU558274 AW136716 BM821221 BG387386 CR598953 
    BU731926 CR610183 AW731994 NM_021126 BU615893 BI520499 CR614516 AW024418 
    AI336543 BM830614 BX393975 CA396744 BX388237 BM766817 AW079544 CR615675 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MPST (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
    SP1:              -                                                               
    SP2:              -     -                 -     -                                 
    SP3:                    -                 -     -                                 
    SP4:                                                                              
    SP5:                                      -                                       


    ECgene alternative splicing isoforms for MPST

    Expression
    for MPST gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MPST expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGCGCCCGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MPST Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MPST

    SOURCE GeneReport for Unigene cluster: Hs.248267
        SABiosciences Expression via Pathway-Focused PCR Array including MPST: 
              Amino Acid Metabolism I in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPST
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MPST
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPST
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPST

    Orthologs
    for MPST gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for MPST gene from 10/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mpst1 , 5 mercaptopyruvate sulfurtransferase1, 5 83.67(n)1
    84.8(a)1    		   15 (37.47 cM)5
    2462211  NM_001162492.11  NP_001155964.11 
     784067125 
    chicken
    (Gallus gallus)    		 Aves MPST1 mercaptopyruvate sulfurtransferase 70.61(n)
    73.65(a)    		   418048  XM_416283.2  XP_416283.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MPST6
    		 --
    		 75(a)
    		 1 ↔ 1
    		 5(22686008-22687570)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.36782 Xenopus laevis transcribed sequence with weak similarity more 73.19(n)    BJ042181.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1625441 zgc:162544 58.68(n)
    58.68(a)    		   796025  NM_001089346.1  NP_001082815.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea mpst-56
    mpst-66
    (see all 7)    		 --
    		 22(a)
    22(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 IV(8567170-8568163)
    IV(8563591-8564584)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes TUM1(YOR251C)4
    TUM11    		 Rhodanese domain sulfur transferase, accepts persulfite more4
    Tum1p1    		 46.22(n)1
    40.24(a)1    		   15(803464-802550)4
    8544251, 4  NP_014894.31  NP_014894.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MST11 thiosulfate sulfurtransferase 48.36(n)
    45.45(a)    		   844264  NM_106574.2  NP_565203.1 
    rice
    (Oryza sativa)    		 Liliopsida Os12g06086001 hypothetical protein 47.74(n)
    44.6(a)    		   4352752  NM_001073769.1  NP_001067237.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria sseA6
    ynjE6
    		 predicted thiosulfate sulfur transferase
    		 39(a)
    15(a)
    		 many → 1
    possible ortholog
    		 Chromosome(2650516-2651361)
    Chromosome(1837491-1838798)


    ENSEMBL Gene Tree for MPST (if available)
    TreeFam Gene Tree for MPST (if available) 

    Paralogs
    for MPST gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MPST gene
    TST2  
    1 SIMAP similar gene for MPST using alignment to 6 protein entries:     THTM_HUMAN (see all proteins):
    TST

    MPST for paralogs           About GeneDecksing



    Genomic Variants
    for MPST gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/178 NCBI SNPs in MPST are shown (see all 178)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1406748521,2
    		--37413731(+) CCTGCA/GGGGAG 4 -- us2k1 int10--------
    rs1922409471,2
    		--37413791(+) AGAAGC/GTGGAT 5 -- us2k1 int10--------
    rs1126061621,2
    		F,--37413887(+) AGCTGG/ATGCCT 5 -- int1 us2k11Minor allele frequency- A:0.50CSA 4
    rs2014239461,2
    		--37414168(+) GCACTA/GGGACA 5 -- int1 us2k10--------
    rs121573091,2
    		C,F,H--37414784(+) CAGCTC/TTGCGT 5 -- ut51 us2k15Minor allele frequency- T:0.01EA NS NA 508
    rs1146195861,2
    		C,F,--37414801(+) TGGCAC/TGGGTG 5 -- int1 us2k11Minor allele frequency- T:0.14WA 118
    rs72884291,2
    		C,F,--37414983(+) GCCCCG/ACCCCT 5 -- int1 us2k13Minor allele frequency- A:0.19NA 124
    rs1894015511,2
    		--37415232(+) GCACAA/CGCCAT 5 -- us2k1 int10--------
    rs1418509391,2
    		--37415285(+) GAGTGC/TCCGAG 5 -- int1 us2k10--------
    rs616796341,2
    		F,--37415300(+) GCCCGT/CAGCTC 5 -- int1 us2k11Minor allele frequency- C:0.06WA 118

    HapMap Linkage Disequilibrium report for MPST (37415676 - 37425863 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MPST
         1 CNV: 47855
    Human Gene Mutation Database (HGMD): MPST

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPST
    DNA2.0 Custom Variant and Variant Library Synthesis for MPST

    Disorders / Diseases
    for MPST gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MPST for disorders           About GeneDecksing

    OMIM gene information: 602496    OMIM disorders: --

    8 diseases for MPST:    About MalaCards
    protein s deficiency    polycythemia vera    polycythemia    acute pancreatitis
    pancreatitis    obesity    tuberculosis    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: MPST (1 document)

    Export disorders for MPST gene to outside databases

    Publications
    for MPST gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MPST gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with MPST)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequence analysis of the human liver rhodanese: comparison with the bovine and chicken enzymes. (PubMed id 1953758)1, 2, 3 Pallini R.... Cacace M.G. (1991)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    4. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    5. Evidence for a functional genetic polymorphism of the human mercaptopyruvate sulfurtransferase (MPST), a cyanide detoxification enzyme. (PubMed id 16545926)1, 9 Billaut-Laden I.... Broly F. (2006)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. The expression and activity of cystathionine-I^-lyase and 3-mercaptopyruvate sulfurtransferase in human neoplastic cell lines. (PubMed id 20446008)1 Jurkowska H....WrA^bel M. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    External Searches for MPST gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MPST gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4357 HGNC: 7223 AceView: MPST Ensembl:ENSG00000128309 euGenes: HUgn4357
    ECgene: MPST Kegg: 4357 H-InvDB: MPST

    Other Databases showing MPST gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MPST gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MPST Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MPST gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MPST gene:
    Search GeneIP for patents involving MPST

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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