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Aliases for MPST Gene

Aliases for MPST Gene

  • Mercaptopyruvate Sulfurtransferase 2 3
  • TRNA Thiouridin Modification Protein 1 2 3
  • Human Liver Rhodanese 2 3
  • TST2 3 4
  • MST 3 4
  • 3-Mercaptopyruvate Sulfurtransferase 3
  • EC 2.8.1.2 4
  • TUM1 3

External Ids for MPST Gene

Summaries for MPST Gene

Entrez Gene Summary for MPST Gene

  • This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MPST Gene

MPST (Mercaptopyruvate Sulfurtransferase) is a Protein Coding gene. Diseases associated with MPST include aminoaciduria. Among its related pathways are Metabolism and Sulfur relay system. GO annotations related to this gene include thiosulfate sulfurtransferase activity and 3-mercaptopyruvate sulfurtransferase activity. An important paralog of this gene is TST.

UniProtKB/Swiss-Prot for MPST Gene

  • Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions (By similarity).

Gene Wiki entry for MPST Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPST Gene

Genomics for MPST Gene

Genomic Location for MPST Gene

Start:
37,019,635 bp from pter
End:
37,029,822 bp from pter
Size:
10,188 bases
Orientation:
Plus strand

Genomic View for MPST Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPST Gene

Regulatory Elements for MPST Gene

Proteins for MPST Gene

  • Protein details for MPST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25325-THTM_HUMAN
    Recommended name:
    3-mercaptopyruvate sulfurtransferase
    Protein Accession:
    P25325
    Secondary Accessions:
    • A8MZ34
    • B3KP52
    • J3KPV7
    • O75750
    • Q6FHN9

    Protein attributes for MPST Gene

    Size:
    297 amino acids
    Molecular mass:
    33178 Da
    Quaternary structure:
    • Monomer; active form. Homodimer; disulfide-linked, inactive form.
    Miscellaneous:
    • Thioredoxin (Trx) or dihydrolipoic acid (DHLA) are required to release hydrogen sulfide from the persulfide intermediate.
    SequenceCaution:
    • Sequence=AAH16737.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAG30409.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MPST Gene

    Alternative splice isoforms for MPST Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPST Gene

Proteomics data for MPST Gene at MOPED

Post-translational modifications for MPST Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MPST Gene

Domains for MPST Gene

Protein Domains for MPST Gene

UniProtKB/Swiss-Prot:

THTM_HUMAN
Domain:
  • Contains two rhodanese domains with different primary structures but with near identical secondary structure conformations suggesting a common evolutionary origin. Only the C-terminal rhodanese domain contains the catalytic cysteine residue (By similarity).:
    • P25325
  • Contains 2 rhodanese domains.:
    • P25325
genes like me logo Genes that share domains with MPST: view

Function for MPST Gene

Molecular function for MPST Gene

GENATLAS Biochemistry: mercaptopyruvate sulfurtransferase
UniProtKB/Swiss-Prot CatalyticActivity: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate
UniProtKB/Swiss-Prot EnzymeRegulation: By oxidative stress, and thioredoxin. Under oxidative stress conditions, the catalytic cysteine site is converted to a sulfenate which inhibits the MPST enzyme activity. Reduced thioredoxin cleaves an intersubunit disulfide bond to turn on the redox switch and reactivate the enzyme
UniProtKB/Swiss-Prot Function: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions (By similarity).

Enzyme Numbers (IUBMB) for MPST Gene

Gene Ontology (GO) - Molecular Function for MPST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004792 thiosulfate sulfurtransferase activity IEA --
GO:0016784 3-mercaptopyruvate sulfurtransferase activity IEA --
genes like me logo Genes that share ontologies with MPST: view

miRNA for MPST Gene

miRTarBase miRNAs that target MPST

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MPST Gene

Localization for MPST Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPST Gene

Cytoplasm. Mitochondrion. Cell junction, synapse, synaptosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MPST Gene COMPARTMENTS Subcellular localization image for MPST gene
Compartment Confidence
mitochondrion 4
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MPST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IEA --
GO:0030054 cell junction IEA --
GO:0043005 neuron projection ISS --
genes like me logo Genes that share ontologies with MPST: view

Pathways for MPST Gene

genes like me logo Genes that share pathways with MPST: view

Pathways by source for MPST Gene

Interacting Proteins for MPST Gene

Selected Interacting proteins: P25325-THTM_HUMAN for MPST Gene via I2D

Gene Ontology (GO) - Biological Process for MPST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0009440 cyanate catabolic process TAS 9070219
GO:0009636 response to toxic substance TAS 9070219
GO:0070814 hydrogen sulfide biosynthetic process ISS --
genes like me logo Genes that share ontologies with MPST: view

Compounds for MPST Gene

(8) HMDB Compounds for MPST Gene

Compound Synonyms Cas Number PubMed IDs
3-Mercaptolactate-cysteine disulfide
  • 3-((2-carboxy-2-hydroxyethyl)dithio)-L-Alanine
18841-42-4
3-Mercaptopyruvic acid
  • 3-Mercaptopyruvate
2464-23-5
Cyanide
  • Carbon nitride ion
57-12-5
Ethanol
  • 1-Hydroxyethane
64-17-5
Pyruvic acid
  • 2-Oxopropanoate
127-17-3

(7) Novoseek inferred chemical compound relationships for MPST Gene

Compound -log(P) Hits PubMed IDs
3-mercaptopyruvate 98.9 31
thiosulfate 75.6 2
thiocyanate 67.3 2
cyanide 67.3 11
sulfur 49.5 3
genes like me logo Genes that share compounds with MPST: view

Transcripts for MPST Gene

Unigene Clusters for MPST Gene

Mercaptopyruvate sulfurtransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MPST Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: -
SP2: - - - -
SP3: - - -
SP4:
SP5: -
SP6:
SP7: - - -

Relevant External Links for MPST Gene

GeneLoc Exon Structure for
MPST
ECgene alternative splicing isoforms for
MPST

Expression for MPST Gene

mRNA expression in normal human tissues for MPST Gene

mRNA differential expression in normal tissues according to GTEx for MPST Gene

This gene is overexpressed in Liver (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MPST Gene

SOURCE GeneReport for Unigene cluster for MPST Gene Hs.248267

genes like me logo Genes that share expressions with MPST: view

Orthologs for MPST Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MPST Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MPST 36
  • 98.84 (n)
  • 98.74 (a)
MPST 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MPST 36
  • 86.46 (n)
  • 88.89 (a)
MPST 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MPST 36
  • 89.9 (n)
  • 90.91 (a)
MPST 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mpst 36
  • 83.67 (n)
  • 84.8 (a)
Mpst 16
Mpst 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MPST 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MPST 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mpst 36
  • 82.43 (n)
  • 85.14 (a)
chicken
(Gallus gallus)
Aves MPST 36
  • 70.61 (n)
  • 73.65 (a)
MPST 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MPST 37
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3678 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mpst 36
  • 63.96 (n)
  • 66.55 (a)
Str.1400 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2809 36
zebrafish
(Danio rerio)
Actinopterygii MPST 37
  • 56 (a)
OneToMany
zgc:162544 36
  • 58.68 (n)
  • 58.68 (a)
worm
(Caenorhabditis elegans)
Secernentea mpst-1 37
  • 21 (a)
ManyToMany
mpst-2 37
  • 23 (a)
ManyToMany
mpst-3 37
  • 22 (a)
ManyToMany
mpst-4 37
  • 23 (a)
ManyToMany
mpst-5 37
  • 26 (a)
ManyToMany
mpst-6 37
  • 26 (a)
ManyToMany
mpst-7 37
  • 18 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL096W 36
  • 45.48 (n)
  • 36.43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUM1 36
  • 46.04 (n)
  • 40.47 (a)
TUM1 37
  • 24 (a)
OneToMany
TUM1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09966g 36
  • 44.44 (n)
  • 37.4 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MST1 36
  • 48.23 (n)
  • 45.45 (a)
rice
(Oryza sativa)
Liliopsida Os12g0608600 36
  • 48.11 (n)
  • 45.39 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06017 36
  • 49.72 (n)
  • 39.39 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tum1 36
  • 45.31 (n)
  • 40.62 (a)
Species with no ortholog for MPST:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPST Gene

ENSEMBL:
Gene Tree for MPST (if available)
TreeFam:
Gene Tree for MPST (if available)

Paralogs for MPST Gene

Paralogs for MPST Gene

Selected SIMAP similar genes for MPST Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MPST: view

Variants for MPST Gene

Sequence variations from dbSNP and Humsavar for MPST Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs1049282 -- 37,029,732(+) ACAAC(A/T)CCGAG utr-variant-3-prime
rs2187723 -- 37,026,349(+) GCACT(C/G)AGCTC intron-variant
rs3753143 -- 37,027,101(+) GCATG(C/T)GCCAC intron-variant, utr-variant-3-prime
rs3753144 -- 37,027,444(+) TCTAG(A/G)TTGGG intron-variant, utr-variant-3-prime
rs3753145 -- 37,027,445(+) CTAGG(G/T)TGGGC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MPST Gene

Variant ID Type Subtype PubMed ID
nsv834187 CNV Loss 17160897
esv34015 CNV Loss 18971310
nsv459882 CNV Gain 19166990
nsv829203 CNV Loss 20364138
dgv4960n71 CNV Loss 21882294
nsv3622 CNV Insertion 18451855
esv2661268 CNV Deletion 23128226

Relevant External Links for MPST Gene

HapMap Linkage Disequilibrium report
MPST
Human Gene Mutation Database (HGMD)
MPST

Disorders for MPST Gene

UniProtKB/Swiss-Prot

THTM_HUMAN
  • Note=Aberrant MPST activity is found in a few cases of mercaptolactate-cysteine disulfiduria (MCDU) characterized by the appearance of large quantaties of the sulfur-containing amino acid, beta-mercaptolactate-cysteine disulfide, in the urine (PubMed:4973015, PubMed:4690911 and PubMed:6945862). Some cases have associated mental retardation (PubMed:4973015 and PubMed:6945862).

(1) MalaCards Diseases for MPST Gene

Search for MPST Gene in MalaCards »

Relevant External Links for MPST

Genetic Association Database (GAD)
MPST
Human Genome Epidemiology (HuGE) Navigator
MPST
genes like me logo Genes that share disorders with MPST: view

Publications for MPST Gene

  1. Cloning and sequence analysis of the human liver rhodanese: comparison with the bovine and chicken enzymes. (PMID: 1953758) Pallini R. … Cacace M.G. (Biochem. Biophys. Res. Commun. 1991) 2 3 4
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  3. Evidence for a functional genetic polymorphism of the human mercaptopyruvate sulfurtransferase (MPST), a cyanide detoxification enzyme. (PMID: 16545926) Billaut-Laden I. … Broly F. (Toxicol. Lett. 2006) 3 23
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for MPST Gene

Sources for MPST Gene

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