Aliases for MPRIP Gene
External Ids for MPRIP Gene
Previous GeneCards Identifiers for MPRIP Gene
GeneCards Summary for MPRIP Gene
MPRIP (Myosin Phosphatase Rho Interacting Protein) is a Protein Coding gene. Diseases associated with MPRIP include gangliocytoma. Among its related pathways are Cytoskeletal Signaling. GO annotations related to this gene include phospholipid binding and actin binding. An important paralog of this gene is TRIOBP.
UniProtKB/Swiss-Prot for MPRIP Gene
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.