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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MPRIP Gene

protein-coding   GIFtS: 53
GCID: GC17P016946

myosin phosphatase Rho interacting protein

 Explore 8 diseases affiliated with
MPRIP via our new
 Human Malady Compendium 
Biological research products
for MPRIP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Myosin Phosphatase Rho Interacting Protein1 2     KIAA08643 5
M-RIP1 2 3     Myosin Phosphatase Rho-Interacting Protein2
RHOIP31 2 3     Rho Interacting Protein 32
P116Rip1     Rho-Interacting Protein 33
MRIP2 3 5     P116RIP5
RIP32 3 5     

External Ids:    HGNC: 303211   Entrez Gene: 231642   Ensembl: ENSG000001330307   OMIM: 6129355   UniProtKB: Q6WCQ13   

Export aliases for MPRIP gene to outside databases

Previous GC identifers: GC17P016888 GC17P016701


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MPRIP_HUMAN, Q6WCQ1
Function: Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton
by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through
stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region
leads to disassembly of stress fibers in neuronal cells

Gene Wiki entry for MPRIP (M-RIP)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MPRIP gene promoter:
         HFH-3   AML1a   Nkx2-5   LCR-F1   NF-kappaB   AREB6   FOXI1   NF-kappaB2   c-Myb   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMPRIP promoter sequence
   Search SABiosciences Chromatin IP Primers for MPRIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPRIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

MPRIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPRIP gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P016946:  view genomic region     (about GC identifiers)

Start:
16,945,859 bp from pter      End:
17,120,993 bp from pter
Size:
175,135 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MPRIP_HUMAN, Q6WCQ1 (See protein sequence)
Recommended Name: Myosin phosphatase Rho-interacting protein  
Size: 1025 amino acids; 116533 Da
Subunit: Binds F-actin through its N-terminus. Interacts with MYZAP (By similarity). Binds RHOA, PPP1R12A/MBS and
PPP1R12C/MBS85 through adjacent coiled coil domains
Subcellular location: Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin
Secondary accessions: Q3KQZ5 Q5FB94 Q6DHW2 Q7Z5Y2 Q8N390 Q96G40
Alternative splicing: 3 isoforms:  Q6WCQ1-1   Q6WCQ1-2   Q6WCQ1-3   

Explore the universe of human proteins at neXtProt for MPRIP: NX_Q6WCQ1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6WCQ1

  • MPRIP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_055949.2  NP_958431.2  

    ENSEMBL proteins: 
     ENSP00000462532   ENSP00000379151   ENSP00000379156   ENSP00000342379   ENSP00000462688  
     ENSP00000464983   ENSP00000317786   ENSP00000412147   ENSP00000411723   ENSP00000464276  
     ENSP00000465902   ENSP00000463367   ENSP00000400189   ENSP00000379149  

    Human Recombinant Protein Products: 
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    Uscn Proteins for MPRIP

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--


    MPRIP for ontologies           About GeneDecksing



    MPRIP Antibody Products: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MPRIP for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q6WCQ1

    ProtoNet protein and cluster: Q6WCQ1

    1 Blocks protein family: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: MPRIP_HUMAN, Q6WCQ1
    Similarity: Contains 2 PH domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MPRIP_HUMAN, Q6WCQ1
    Function: Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton
    by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through
    stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region
    leads to disassembly of stress fibers in neuronal cells

    miRNA
    Products:
        
    miRTarBase miRNAs that target MPRIP:
    hsa-mir-31 (MIRT004977)

    OriGene 3'-UTR Clone (see all 2): MPRIP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPRIP
    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate MPRIP (see all 78):
    hsa-miR-194* hsa-miR-411* hsa-miR-548j hsa-miR-582-3p hsa-miR-200a hsa-miR-605 hsa-miR-3138 hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmidMPRIP 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPRIP (see all 4)
    OriGene shRNA RFP: MPRIP
    OriGene siRNA: MPRIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPRIP

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPRIP 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPRIP

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005543phospholipid binding IEA--


    MPRIP for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MPRIP:
     Increased Akt phosphorylation   Increased Salmonella enterica  


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeletal Signaling
    Cytoskeletal Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MPRIP
        Cytoskeletal Signaling



    MPRIP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MPRIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/26 Interacting proteins for MPRIP (Q6WCQ12, 3 ENSP000003791564) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319462, 3, ENSP000003001614MINT-50982 I2D: score=4 STRING: ENSP00000300161
    YWHAGP619812, 3, ENSP000003063304MINT-50864 I2D: score=4 STRING: ENSP00000306330
    PPP1R12AO149742, 3, ENSP000002612074MINT-72807 I2D: score=3 STRING: ENSP00000261207
    PPP1R12CQ9BZL42, 3, ENSP000002634334MINT-72806 I2D: score=3 STRING: ENSP00000263433
    SFNP319472, 3MINT-3976316 MINT-3975088 I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MPRIP
    Search CenterWatch for drugs/clinical trials and news about MPRIP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MPRIP gene (2 alternative transcripts): 
    NM_015134.3  NM_201274.3  

    Unigene Cluster for MPRIP:

    Myosin phosphatase Rho interacting protein
    Hs.462341  [show with all ESTs]
    Unigene Representative Sequence: NM_201274
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000577514 ENST00000395806 ENST00000395807 ENST00000395811(uc002gqu.2 uc002gqv.2)
    ENST00000341712(uc002gqw.2 uc010cpl.2 uc010cpm.2) ENST00000584936
    ENST00000584067 ENST00000466186 ENST00000578521 ENST00000581955 ENST00000579832
    ENST00000313485(uc002gqx.2 uc002gqy.2) ENST00000414263 ENST00000578548
    ENST00000429184 ENST00000581855 ENST00000578209 ENST00000462033

    miRNA
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    OriGene 3'-UTR Clone (see all 2): MPRIP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPRIP
    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate MPRIP (see all 78):
    hsa-miR-194* hsa-miR-411* hsa-miR-548j hsa-miR-582-3p hsa-miR-200a hsa-miR-605 hsa-miR-3138 hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmidMPRIP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPRIP (see all 4)
    OriGene shRNA RFP: MPRIP
    OriGene siRNA: MPRIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPRIP
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MPRIP (NM_015134)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPRIP 
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPRIP
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPRIP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPRIP

    Additional cDNA sequence: 

    AB020671.2 AB098507.1 AB189741.1 AB362572.1 AB362573.1 AJ844625.1 AK025229.1 AK025604.1 
    AK026035.1 AK091337.1 AK092287.1 AL834513.1 AY296247.1 BC009982.2 BC012426.1 BC014102.2 
    BC021058.1 BC021070.1 BC030255.1 BC050323.1 BC063588.1 BC075847.1 BC105987.1 BC136479.1 
    D23673.1 

    24/35 DOTS entries (see all 35):

    DT.95265234  DT.101985347  DT.86853068  DT.413274  DT.448305  DT.40292329  DT.92409954  DT.100825397 
    DT.100838545  DT.102833356  DT.95156348  DT.40196182  DT.40225318  DT.75101296  DT.100661514  DT.120933238 
    DT.120933166  DT.96086352  DT.40262573  DT.91680561  DT.120928232  DT.75103098  DT.91960111  DT.92444155 

    24/474 AceView cDNA sequences (see all 474):

    AI365361 BE271582 AA557530 BE675880 BX113004 AI147461 AA768882 AA861469 
    BU845894 AI431694 NM_015134 BQ014065 AA378192 AA911222 BE048871 AI313170 
    AI138662 BM826076 CF264684 AI572257 BQ002253 CA405897 CA425865 C16497 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MPRIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCTGGTGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MPRIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MPRIP

    SOURCE GeneReport for Unigene cluster: Hs.462341
        SABiosciences Custom PCR Arrays for MPRIP
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPRIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MPRIP gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves MPRIP1 myosin phosphatase Rho interacting protein 81.39(n)
    86.6(a)
      416502  XM_414806.3  XP_414806.3 
    lizard
    (Anolis carolinensis)
    Reptilia MPRIP6
    --
    34(a)
    1 ↔ 1
    GL343500.1(410056-486466)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX774129.12   -- 81.42(n)    BX774129.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1752221 zgc:175222 65.07(n)
    64.16(a)
      558831  NM_001111159.1  NP_001104629.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta osp6
    outspread
    14(a)
    1 → many
    2L(14599776-14689325)
    worm
    (Caenorhabditis elegans)
    Secernentea F10G8.81 Protein F10G8.8 38.9(n)
    28.34(a)
      172870  NM_001128978.1  NP_001122450.1 


    ENSEMBL Gene Tree for MPRIP (if available)
    TreeFam Gene Tree for MPRIP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MPRIP gene
    TRIOBP2  
    4 SIMAP similar genes for MPRIP using alignment to 13 protein entries:     MPRIP_HUMAN (see all proteins):
    M-RIP    KIAA0864    DKFZp547M048    TRIOBP

    MPRIP for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MPRIP
    PGOHUM00000250236


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2427 NCBI SNPs in MPRIP are shown (see all 2427    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs593202771,2
    C,--16944132(+) GAGGCA/GGAGCT 2 -- us2k12Minor allele frequency- G:0.25NA 4
    rs1406654871,2
    --16944156(+) GATCCC/TGCCAC 2 -- us2k10--------
    rs1836289551,2
    --16944308(+) TAATGG/TTCACA 2 -- us2k10--------
    rs1501714391,2
    --16944403(+) GCCTGA/GTGGAG 2 -- us2k10--------
    rs1388993991,2
    --16944432(+) GCTGCC/TAAAGG 2 -- us2k10--------
    rs1893098771,2
    --16944486(+) TTTCTG/TACACT 2 -- us2k10--------
    rs1823008751,2
    --16944542(+) AAAAGC/TACACA 2 -- us2k10--------
    rs116589041,2
    C,F,H,--16944622(+) GCCACT/CACCAC 2 -- us2k125Minor allele frequency- C:0.24NS EA NA WA CSA 2536
    rs1472252501,2
    C,--16944675(+) CCCCC-/CTGTTTA 2 -- us2k10--------
    rs1868892211,2
    --16944675(+) CCCCCC/TTGTTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MPRIP (16945859 - 17120993 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MPRIP
         1 Inversion: 0495

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPRIP
    DNA2.0 Custom Variant and Variant Library Synthesis for MPRIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MPRIP for disorders           About GeneDecksing

    OMIM gene information: 612935    OMIM disorders: --

    8 diseases for MPRIP:    About MalaCards
    supratentorial primitive neuroectodermal tumor    primitive neuroectodermal tumor    gangliocytoma    patau syndrome
    macular degeneration    neuroectodermal tumors    ataxia    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for MPRIP:
    Supratentorial primitive neuroectodermal tumor     Gangliocytoma

    Export disorders for MPRIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MPRIP gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with MPRIP)
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    1. p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA. (PubMed id 15545284)1, 2, 9 Koga Y. and Ikebe M. (2005)
    2. M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells. (PubMed id 16257966)1, 2, 9 Surks H.K.... Ohtani K. (2005)
    3. Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA. (PubMed id 14506264)1, 2, 9 Surks H.K.... Mendelsohn M.E. (2003)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 3 Nagase T....Ohara O. (1998)
    7. M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion. (PubMed id 18636174)1, 9 Ono R....Matsushita M. (2008)
    8. Association of syntenin-1 with M-RIP polarizes Rac-1 a ctivation during chemotaxis and immune interactions. (PubMed id 22349701)1 Sala-Valdes M....Yanez-Mo M. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Interactome mapping suggests new mechanistic details u nderlying Alzheimer's disease. (PubMed id 21163940)1 Soler-Lopez M....Aloy P. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23164 HGNC: 30321 AceView: M-RIP Ensembl:ENSG00000133030 euGenes: HUgn23164
    ECgene: MPRIP H-InvDB: MPRIP

    (According to HUGE)
    About This Section
    HUGE: KIAA0864

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MPRIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MPRIP gene:
    Search GeneIP for patents involving MPRIP

    GeneCards and IP:
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