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Aliases for MPRIP Gene

Aliases for MPRIP Gene

  • Myosin Phosphatase Rho Interacting Protein 2 3 5
  • Rho Interacting Protein 3 2 3
  • P116Rip 3 4
  • RHOIP3 3 4
  • M-RIP 3 4
  • MRIP 3 4
  • RIP3 3 4
  • Rho-Interacting Protein 3 4
  • KIAA0864 4

External Ids for MPRIP Gene

Previous GeneCards Identifiers for MPRIP Gene

  • GC17P016888
  • GC17P016946
  • GC17P016701

Summaries for MPRIP Gene

GeneCards Summary for MPRIP Gene

MPRIP (Myosin Phosphatase Rho Interacting Protein) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is TRIOBP.

UniProtKB/Swiss-Prot for MPRIP Gene

  • Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.

Gene Wiki entry for MPRIP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPRIP Gene

Genomics for MPRIP Gene

Regulatory Elements for MPRIP Gene

Promoters for MPRIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MPRIP on UCSC Golden Path with GeneCards custom track

Genomic Location for MPRIP Gene

Chromosome:
17
Start:
17,042,468 bp from pter
End:
17,217,679 bp from pter
Size:
175,212 bases
Orientation:
Plus strand

Genomic View for MPRIP Gene

Genes around MPRIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPRIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPRIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPRIP Gene

Proteins for MPRIP Gene

  • Protein details for MPRIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6WCQ1-MPRIP_HUMAN
    Recommended name:
    Myosin phosphatase Rho-interacting protein
    Protein Accession:
    Q6WCQ1
    Secondary Accessions:
    • Q3KQZ5
    • Q5FB94
    • Q6DHW2
    • Q7Z5Y2
    • Q8N390
    • Q96G40

    Protein attributes for MPRIP Gene

    Size:
    1025 amino acids
    Molecular mass:
    116533 Da
    Quaternary structure:
    • Binds F-actin through its N-terminus. Interacts with MYZAP (By similarity). Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.

    Alternative splice isoforms for MPRIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPRIP Gene

Proteomics data for MPRIP Gene at MOPED

Post-translational modifications for MPRIP Gene

  • Ubiquitination at Lys 396
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MPRIP (RIP3)

No data available for DME Specific Peptides for MPRIP Gene

Domains & Families for MPRIP Gene

Gene Families for MPRIP Gene

Protein Domains for MPRIP Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6WCQ1

UniProtKB/Swiss-Prot:

MPRIP_HUMAN :
  • Contains 2 PH domains.
Domain:
  • Contains 2 PH domains.
genes like me logo Genes that share domains with MPRIP: view

Function for MPRIP Gene

Molecular function for MPRIP Gene

UniProtKB/Swiss-Prot Function:
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.

Gene Ontology (GO) - Molecular Function for MPRIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with MPRIP: view
genes like me logo Genes that share phenotypes with MPRIP: view

Animal Model Products

CRISPR Products

miRNA for MPRIP Gene

miRTarBase miRNAs that target MPRIP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPRIP Gene

Localization for MPRIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPRIP Gene

Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MPRIP Gene COMPARTMENTS Subcellular localization image for MPRIP gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for MPRIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MPRIP: view

Pathways & Interactions for MPRIP Gene

SuperPathways for MPRIP Gene

No Data Available

SIGNOR curated interactions for MPRIP Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MPRIP Gene

None

No data available for Pathways by source for MPRIP Gene

Drugs & Compounds for MPRIP Gene

No Compound Related Data Available

Transcripts for MPRIP Gene

Unigene Clusters for MPRIP Gene

Myosin phosphatase Rho interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MPRIP Gene

No ASD Table

Relevant External Links for MPRIP Gene

GeneLoc Exon Structure for
MPRIP
ECgene alternative splicing isoforms for
MPRIP

Expression for MPRIP Gene

mRNA expression in normal human tissues for MPRIP Gene

Protein differential expression in normal tissues from HIPED for MPRIP Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (36.2) and Bone marrow stromal cell (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPRIP Gene



SOURCE GeneReport for Unigene cluster for MPRIP Gene Hs.462341

genes like me logo Genes that share expression patterns with MPRIP: view

Protein tissue co-expression partners for MPRIP Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MPRIP Gene

Orthologs for MPRIP Gene

This gene was present in the common ancestor of animals.

Orthologs for MPRIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MPRIP 36
  • 97 (a)
OneToOne
MPRIP 35
  • 99.65 (n)
  • 99.9 (a)
cow
(Bos Taurus)
Mammalia M-RIP 36
  • 83 (a)
OneToOne
MPRIP 35
  • 87.85 (n)
  • 91.11 (a)
dog
(Canis familiaris)
Mammalia LOC479530 35
  • 88.77 (n)
  • 92.86 (a)
MPRIP 36
  • 18 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mprip 16
Mprip 35
  • 86.33 (n)
  • 92.17 (a)
Mprip 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MPRIP 36
  • 16 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 18 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mprip 35
  • 85.69 (n)
  • 91.16 (a)
chicken
(Gallus gallus)
Aves MPRIP 35
  • 70.48 (n)
  • 68.06 (a)
MPRIP 36
  • 17 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MPRIP 36
  • 18 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mprip 35
  • 73.59 (n)
  • 78.48 (a)
zebrafish
(Danio rerio)
Actinopterygii MPRIP (1 of 4) 36
  • 57 (a)
OneToMany
MPRIP (2 of 4) 36
  • 20 (a)
OneToMany
MPRIP (3 of 4) 36
  • 12 (a)
OneToMany
MPRIP (4 of 4) 36
  • 51 (a)
OneToMany
si:ch73-103b11.2 35
  • 66.43 (n)
  • 69.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta osp 36
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10G8.8 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for MPRIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPRIP Gene

ENSEMBL:
Gene Tree for MPRIP (if available)
TreeFam:
Gene Tree for MPRIP (if available)

Paralogs for MPRIP Gene

Paralogs for MPRIP Gene

Pseudogenes.org Pseudogenes for MPRIP Gene

genes like me logo Genes that share paralogs with MPRIP: view

Variants for MPRIP Gene

Sequence variations from dbSNP and Humsavar for MPRIP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3744137 - 17,142,710(-) TGGAT(G/T)GTGAG reference, missense
rs1544695 -- 17,149,725(+) taaat(A/G)tataa intron-variant
rs1124961 -- 17,135,071(+) GATGT(A/G)CTTCA intron-variant
rs1135237 -- 17,097,232(+) AAAAT(C/G)GGTTC intron-variant
rs1567815 -- 17,171,424(-) GGGGA(C/G)AGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPRIP Gene

Variant ID Type Subtype PubMed ID
nsv155 OTHER Inversion 15895083
nsv499114 OTHER Inversion 21111241
nsv1995 CNV Insertion 18451855
esv270554 CNV Insertion 20981092
esv2299362 CNV Deletion 18987734
esv2715714 CNV Deletion 23290073
nsv907728 CNV Loss 21882294
esv2676412 CNV Deletion 23128226
nsv524958 CNV Loss 19592680
nsv1996 CNV Insertion 18451855
nsv833380 CNV Loss 17160897

Variation tolerance for MPRIP Gene

Residual Variation Intolerance Score: 2.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPRIP Gene

HapMap Linkage Disequilibrium report
MPRIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPRIP Gene

Disorders for MPRIP Gene

Relevant External Links for MPRIP

Genetic Association Database (GAD)
MPRIP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MPRIP

No disorders were found for MPRIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPRIP Gene

Publications for MPRIP Gene

  1. p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA. (PMID: 15545284) Koga Y. … Ikebe M. (J. Biol. Chem. 2005) 3 4 23 67
  2. M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion. (PMID: 18636174) Ono R. … Matsushita M. (Int. J. Mol. Med. 2008) 3 23
  3. M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells. (PMID: 16257966) Surks H.K. … Ohtani K. (J. Biol. Chem. 2005) 3 23
  4. Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA. (PMID: 14506264) Surks H.K. … Mendelsohn M.E. (J. Biol. Chem. 2003) 3 23
  5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3

Products for MPRIP Gene

Sources for MPRIP Gene

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