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MPRIP Gene

protein-coding   GIFtS: 55
GCID: GC17P016946

Myosin Phosphatase Rho Interacting Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin Phosphatase Rho Interacting Protein1 2     p116Rip2 3
MRIP2 3 5     KIAA08643 5
RIP32 3 5     Myosin Phosphatase Rho-Interacting Protein2
Rho Interacting Protein 31 2     Rho-Interacting Protein 33
M-RIP2 3     P116RIP5
RHOIP32 3     

External Ids:    HGNC: 303211   Entrez Gene: 231642   Ensembl: ENSG000001330307   OMIM: 6129355   UniProtKB: Q6WCQ13   

Export aliases for MPRIP gene to outside databases

Previous GC identifers: GC17P016888 GC17P016701


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MPRIP Gene:
MPRIP (myosin phosphatase Rho interacting protein) is a protein-coding gene. Diseases associated with MPRIP include gangliocytoma, and patau syndrome. GO annotations related to this gene include actin binding and phospholipid binding. An important paralog of this gene is TRIOBP.

UniProtKB/Swiss-Prot: MPRIP_HUMAN, Q6WCQ1
Function: Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin
cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells
through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its
F-actin-binding region leads to disassembly of stress fibers in neuronal cells

Gene Wiki entry for MPRIP (M-RIP) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MPRIP gene promoter:
         HFH-3   AML1a   Nkx2-5   LCR-F1   NF-kappaB   AREB6   FOXI1   NF-kappaB2   c-Myb   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMPRIP promoter sequence
   Search Chromatin IP Primers for MPRIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MPRIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

MPRIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPRIP gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P016946:  view genomic region     (about GC identifiers)

Start:
16,945,859 bp from pter      End:
17,120,993 bp from pter
Size:
175,135 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MPRIP_HUMAN, Q6WCQ1 (See protein sequence)
Recommended Name: Myosin phosphatase Rho-interacting protein  
Size: 1025 amino acids; 116533 Da
Subunit: Binds F-actin through its N-terminus. Interacts with MYZAP (By similarity). Binds RHOA, PPP1R12A/MBS and
PPP1R12C/MBS85 through adjacent coiled coil domains
Secondary accessions: Q3KQZ5 Q5FB94 Q6DHW2 Q7Z5Y2 Q8N390 Q96G40
Alternative splicing: 3 isoforms:  Q6WCQ1-1   Q6WCQ1-2   Q6WCQ1-3   

Explore the universe of human proteins at neXtProt for MPRIP: NX_Q6WCQ1

Explore proteomics data for MPRIP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys396
  • Modification sites at PhosphoSitePlus

  • See MPRIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_055949.2  NP_958431.2  

    ENSEMBL proteins: 
     ENSP00000462532   ENSP00000379151   ENSP00000379156   ENSP00000342379   ENSP00000462688  
     ENSP00000464983   ENSP00000317786   ENSP00000412147   ENSP00000411723   ENSP00000464276  
     ENSP00000465902   ENSP00000463367   ENSP00000400189   ENSP00000379149  

    MPRIP Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MPRIP

    MPRIP Antibody Products:

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    Cloud-Clone Corp. CLIAs for MPRIP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    2 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q6WCQ1

    ProtoNet protein and cluster: Q6WCQ1

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: MPRIP_HUMAN, Q6WCQ1
    Similarity: Contains 2 PH domains


    MPRIP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPRIP_HUMAN, Q6WCQ1
    Function: Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin
    cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells
    through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its
    F-actin-binding region leads to disassembly of stress fibers in neuronal cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI15545284
         
    MPRIP for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MPRIP:
     Increased Akt phosphorylation   Increased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MPRIP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MPRIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MPRIP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MPRIP

    miRNA
    Products:
        
    miRTarBase miRNAs that target MPRIP:
    hsa-mir-1296-5p (MIRT036110), hsa-mir-1909-3p (MIRT035803), hsa-mir-1 (MIRT023650), hsa-mir-31-5p (MIRT004977), hsa-mir-324-3p (MIRT042870), hsa-mir-124-3p (MIRT023094)

    Block miRNA regulation of human, mouse, rat MPRIP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MPRIP (see all 78):
    hsa-miR-194* hsa-miR-411* hsa-miR-548j hsa-miR-582-3p hsa-miR-200a hsa-miR-605 hsa-miR-3138 hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmidMPRIP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MPRIP

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): MPRIP (NM_015134)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPRIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPRIP

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPRIP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MPRIP_HUMAN, Q6WCQ1: Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005856cytoskeleton ----
    GO:0015629actin cytoskeleton IDA--

    MPRIP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MPRIP About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MPRIP
        Cytoskeletal Signaling



    MPRIP for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MPRIP
    Interactions:

        GeneGlobe Interaction Network for MPRIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for MPRIP (Q6WCQ11, 2, 3 ENSP000003791564) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319462, 3, ENSP000003001614MINT-50982 I2D: score=4 STRING: ENSP00000300161
    YWHAGP619812, 3, ENSP000003063304MINT-50864 I2D: score=4 STRING: ENSP00000306330
    PPP1R12AO149742, 3, ENSP000002612074MINT-72807 I2D: score=3 STRING: ENSP00000261207
    PPP1R12CQ9BZL42, 3, ENSP000002634334MINT-72806 I2D: score=3 STRING: ENSP00000263433
    SFNP319472, 3MINT-3976316 MINT-3975088 I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MPRIP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MPRIP gene (2 alternative transcripts): 
    NM_015134.3  NM_201274.3  

    Unigene Cluster for MPRIP:

    Myosin phosphatase Rho interacting protein
    Hs.462341  [show with all ESTs]
    Unigene Representative Sequence: NM_201274
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000577514 ENST00000395806 ENST00000395807 ENST00000395811(uc002gqu.2 uc002gqv.2)
    ENST00000341712(uc002gqw.2 uc010cpl.2 uc010cpm.2) ENST00000584936
    ENST00000584067 ENST00000466186 ENST00000578521 ENST00000581955 ENST00000579832
    ENST00000313485(uc002gqx.2 uc002gqy.2) ENST00000414263 ENST00000578548
    ENST00000429184 ENST00000581855 ENST00000578209 ENST00000462033
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MPRIP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MPRIP (see all 78):
    hsa-miR-194* hsa-miR-411* hsa-miR-548j hsa-miR-582-3p hsa-miR-200a hsa-miR-605 hsa-miR-3138 hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmidMPRIP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MPRIP
    Predesigned siRNA for gene silencing in human, mouse, rat MPRIP
    Clone
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    OriGene clones in human, mouse for MPRIP (see all 13)
    OriGene ORF clones in mouse, rat for MPRIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MPRIP (NM_015134)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPRIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPRIP
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MPRIP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MPRIP
      QuantiTect SYBR Green Assays in human, mouse, rat MPRIP
      QuantiFast Probe-based Assays in human, mouse, rat MPRIP

    Additional mRNA sequence: 

    AB020671.2 AB098507.1 AB189741.1 AB362572.1 AB362573.1 AJ844625.1 AK025229.1 AK025604.1 
    AK026035.1 AK091337.1 AK092287.1 AL834513.1 AY296247.1 BC009982.2 BC012426.1 BC014102.2 
    BC021058.1 BC021070.1 BC030255.1 BC050323.1 BC063588.1 BC075847.1 BC105987.1 BC136479.1 
    D23673.1 

    Selected DOTS entries (see all 36):

    DT.95265234  DT.101985347  DT.86853068  DT.40292329  DT.413274  DT.448305  DT.92409954  DT.100825397 
    DT.100838545  DT.102833356  DT.95156348  DT.40196182  DT.40225318  DT.75101296  DT.100661514  DT.120933238 
    DT.120933166  DT.96086352  DT.40262573  DT.91680561  DT.120928232  DT.75103098  DT.91960111  DT.92444155 

    Selected AceView cDNA sequences (see all 474):

    BQ772502 AI570799 BC075847 CA448522 BM684577 BE550367 BU849919 CK300038 
    AA514278 AI435265 BQ014065 BE551522 AA732243 BU608310 AI344296 AI431694 
    BC012426 BM793143 BE048871 AI352640 AI738707 AI301205 AW630895 AI926737 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MPRIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGGTGTG
    MPRIP Expression
    About this image

    MPRIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MPRIP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.462341
        Custom PCR Arrays for MPRIP
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPRIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MPRIP gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mprip1 , 5 myosin phosphatase Rho interacting protein1, 5 86.33(n)1
    92.17(a)1
      11 (37.76 cM)5
    269361  NM_201245.31  NP_957697.11 
     596613055 
    chicken
    (Gallus gallus)
    Aves MPRIP1 myosin phosphatase Rho interacting protein 70.48(n)
    68.06(a)
      416502  XM_004945184.1  XP_004945241.1 
    lizard
    (Anolis carolinensis)
    Reptilia MPRIP6
    myosin phosphatase Rho interacting protein
    18(a)
    1 ↔ 1
    GL343500.1(409845-486466)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX774129.12   -- 81.42(n)    BX774129.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-103b11.21 si:ch73-103b11.2 66.43(n)
    69.66(a)
      562530  XM_005162900.1  XP_005162957.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta osp6
    outspread
    9(a)
    1 → many
    2L(14599776-14689325)
    worm
    (Caenorhabditis elegans)
    Secernentea F10G8.86
    Protein F10G8.8, isoform b
    14(a)
    1 → many
    I(10050693-10062028) WBGene00008666


    ENSEMBL Gene Tree for MPRIP (if available)
    TreeFam Gene Tree for MPRIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MPRIP gene
    TRIOBP2  
    4 SIMAP similar genes for MPRIP using alignment to 13 protein entries:     MPRIP_HUMAN (see all proteins):
    M-RIP    KIAA0864    TRIOBP    DKFZp547M048

    MPRIP for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MPRIP
    PGOHUM00000250236


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MPRIP (see all 2902)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs593202771,2
    C--16944132(+) GAGGCA/GGAGCT 2 -- us2k12Minor allele frequency- G:0.25NA 4
    rs1406654871,2
    C--16944156(+) GATCCC/TGCCAC 2 -- us2k10--------
    rs1836289551,2
    --16944308(+) TAATGG/TTCACA 2 -- us2k10--------
    rs1501714391,2
    --16944403(+) GCCTGA/GTGGAG 2 -- us2k10--------
    rs1388993991,2
    --16944432(+) GCTGCC/TAAAGG 2 -- us2k10--------
    rs1893098771,2
    --16944486(+) TTTCTG/TACACT 2 -- us2k10--------
    rs1823008751,2
    --16944542(+) AAAAGC/TACACA 2 -- us2k10--------
    rs116589041,2
    C,F,H--16944622(+) GCCACT/CACCAC 2 -- us2k125Minor allele frequency- C:0.24NS EA NA WA CSA 2536
    rs345448131,2
    C--16944675(+) CCCCC-/CTGTTTA 2 -- us2k10--------
    rs1868892211,2
    --16944675(+) CCCCCC/TTGTTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MPRIP (16945859 - 17120993 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MPRIP (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2299362CNV Deletion18987734
    esv2715714CNV Deletion23290073
    esv2676412CNV Deletion23128226
    esv270554CNV Insertion20981092
    nsv1995CNV Insertion18451855
    nsv1996CNV Insertion18451855
    nsv907728CNV Loss21882294
    nsv833380CNV Loss17160897
    nsv524958CNV Loss19592680
    nsv155OTHER Inversion15895083

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612935    OMIM disorders: --

    10 diseases for MPRIP:    
    About MalaCards
    gangliocytoma    patau syndrome    supratentorial primitive neuroectodermal tumor    primitive neuroectodermal tumor
    diabetic retinopathy    ataxia    atherosclerosis    obesity
    alzheimer's disease    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for MPRIP:
    Supratentorial primitive neuroectodermal tumor     Gangliocytoma

    MPRIP for disorders           About GeneDecksing

    Genetic Association Database (GAD): MPRIP

    Export disorders for MPRIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MPRIP gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with MPRIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA. (PubMed id 15545284)1, 2, 9 Koga Y. and Ikebe M. (J. Biol. Chem. 2005)
    2. M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells. (PubMed id 16257966)1, 2, 9 Surks H.K.... Ohtani K. (J. Biol. Chem. 2005)
    3. Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA. (PubMed id 14506264)1, 2, 9 Surks H.K.... Mendelsohn M.E. (J. Biol. Chem. 2003)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    7. M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion. (PubMed id 18636174)1, 9 Ono R....Matsushita M. (Int. J. Mol. Med. 2008)
    8. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    9. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    10. Association of syntenin-1 with M-RIP polarizes Rac-1 activation during chemotaxis and immune interactions. (PubMed id 22349701)1 Sala-ValdAcs M....YA!A+ez-MA^ M. (J. Cell. Sci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23164 HGNC: 30321 AceView: M-RIP Ensembl:ENSG00000133030 euGenes: HUgn23164
    ECgene: MPRIP H-InvDB: MPRIP

    (According to HUGE)
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    HUGE: KIAA0864

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MPRIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MPRIP gene:
    Search GeneIP for patents involving MPRIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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