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Aliases for MPRIP Gene

Aliases for MPRIP Gene

  • Myosin Phosphatase Rho Interacting Protein 2 3 5
  • Rho Interacting Protein 3 2 3
  • P116Rip 3 4
  • RHOIP3 3 4
  • M-RIP 3 4
  • MRIP 3 4
  • RIP3 3 4
  • Myosin Phosphatase Rho-Interacting Protein 3
  • Rho-Interacting Protein 3 4
  • KIAA0864 4

External Ids for MPRIP Gene

Previous GeneCards Identifiers for MPRIP Gene

  • GC17P016888
  • GC17P016946
  • GC17P016701

Summaries for MPRIP Gene

GeneCards Summary for MPRIP Gene

MPRIP (Myosin Phosphatase Rho Interacting Protein) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Cytoskeletal Signaling. GO annotations related to this gene include actin binding. An important paralog of this gene is TRIOBP.

UniProtKB/Swiss-Prot for MPRIP Gene

  • Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.

Gene Wiki entry for MPRIP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPRIP Gene

Genomics for MPRIP Gene

Regulatory Elements for MPRIP Gene

Enhancers for MPRIP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F017014 1.5 FANTOM5 Ensembl ENCODE 20.6 -23.4 -23436 10.0 TBP PKNOX1 SIN3A PTRF RAD21 ZNF766 GLIS2 ELK1 SCRT2 RCOR1 MPRIP FLCN MPRIP-AS1 PLD6 COPS3 ENSG00000260328 SREBF1 LRRC75A
GH17F017040 1.4 FANTOM5 ENCODE 13.6 +1.4 1396 6.1 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 CBX5 ZNF143 FOS FLCN PLD6 MPRIP-AS1 SMCR5 ZNF624 MPRIP ZNF287 COPS3 RNU6-767P MED9
GH17F016986 1.2 Ensembl ENCODE 15.5 -53.2 -53232 5.5 HDGF PKNOX1 WRNIP1 SIN3A GLI4 ZNF2 GLIS2 ZNF143 FOS JUNB MPRIP FLCN PLD6 PIGL NT5M LINC02090 ENSG00000260328
GH17F016968 1.5 FANTOM5 Ensembl ENCODE 10.7 -67.4 -67352 13.8 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 RAD21 EGR1 ZNF143 ETV6 CREM MPRIP PLD6 TNFRSF13B TBC1D27 LOC644422 LOC284191
GH17F017149 1.3 FANTOM5 Ensembl ENCODE 12.1 +109.1 109062 3.3 CTCF PKNOX1 SIN3A ZIC2 RAD21 NFYB PRDM10 FOS CREM NFE2L2 FLCN MPRIP PLD6 MPRIP-AS1 NT5M PEMT ZNF624 COPS3 GC17M017147 PIR32621
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MPRIP on UCSC Golden Path with GeneCards custom track

Promoters for MPRIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001637074 1032 3401 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 GLIS2 CBX5 ZNF143

Genomic Location for MPRIP Gene

Chromosome:
17
Start:
17,042,468 bp from pter
End:
17,217,679 bp from pter
Size:
175,212 bases
Orientation:
Plus strand

Genomic View for MPRIP Gene

Genes around MPRIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPRIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPRIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPRIP Gene

Proteins for MPRIP Gene

  • Protein details for MPRIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6WCQ1-MPRIP_HUMAN
    Recommended name:
    Myosin phosphatase Rho-interacting protein
    Protein Accession:
    Q6WCQ1
    Secondary Accessions:
    • Q3KQZ5
    • Q5FB94
    • Q6DHW2
    • Q7Z5Y2
    • Q8N390
    • Q96G40

    Protein attributes for MPRIP Gene

    Size:
    1025 amino acids
    Molecular mass:
    116533 Da
    Quaternary structure:
    • Binds F-actin through its N-terminus. Interacts with MYZAP (By similarity). Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.

    Alternative splice isoforms for MPRIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPRIP Gene

Post-translational modifications for MPRIP Gene

  • Ubiquitination at Lys 396
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MPRIP (RIP3)
  • Santa Cruz Biotechnology (SCBT) Antibodies for MPRIP

No data available for DME Specific Peptides for MPRIP Gene

Domains & Families for MPRIP Gene

Gene Families for MPRIP Gene

Protein Domains for MPRIP Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6WCQ1

UniProtKB/Swiss-Prot:

MPRIP_HUMAN :
  • Contains 2 PH domains.
Domain:
  • Contains 2 PH domains.
genes like me logo Genes that share domains with MPRIP: view

Function for MPRIP Gene

Molecular function for MPRIP Gene

UniProtKB/Swiss-Prot Function:
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.

Gene Ontology (GO) - Molecular Function for MPRIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 15545284
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with MPRIP: view
genes like me logo Genes that share phenotypes with MPRIP: view

Animal Model Products

miRNA for MPRIP Gene

miRTarBase miRNAs that target MPRIP

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPRIP Gene

Localization for MPRIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPRIP Gene

Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPRIP gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3

Gene Ontology (GO) - Cellular Components for MPRIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005856 cytoskeleton IEA --
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0005925 focal adhesion IDA 21423176
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with MPRIP: view

Pathways & Interactions for MPRIP Gene

genes like me logo Genes that share pathways with MPRIP: view

Pathways by source for MPRIP Gene

1 Cell Signaling Technology pathway for MPRIP Gene
2 Reactome pathways for MPRIP Gene

SIGNOR curated interactions for MPRIP Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MPRIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with MPRIP: view

Transcripts for MPRIP Gene

Unigene Clusters for MPRIP Gene

Myosin phosphatase Rho interacting protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPRIP Gene

No ASD Table

Relevant External Links for MPRIP Gene

GeneLoc Exon Structure for
MPRIP
ECgene alternative splicing isoforms for
MPRIP

Expression for MPRIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MPRIP Gene

Protein differential expression in normal tissues from HIPED for MPRIP Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (36.2) and Bone marrow stromal cell (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MPRIP Gene



Protein tissue co-expression partners for MPRIP Gene

NURSA nuclear receptor signaling pathways regulating expression of MPRIP Gene:

MPRIP

SOURCE GeneReport for Unigene cluster for MPRIP Gene:

Hs.462341
genes like me logo Genes that share expression patterns with MPRIP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MPRIP Gene

Orthologs for MPRIP Gene

This gene was present in the common ancestor of animals.

Orthologs for MPRIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MPRIP 34 35
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia LOC479530 34
  • 88.77 (n)
MPRIP 35
  • 18 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MPRIP 34
  • 87.85 (n)
M-RIP 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mprip 34 16 35
  • 86.33 (n)
rat
(Rattus norvegicus)
Mammalia Mprip 34
  • 85.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 60 (a)
OneToMany
-- 35
  • 18 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MPRIP 35
  • 16 (a)
OneToOne
chicken
(Gallus gallus)
Aves MPRIP 34 35
  • 70.48 (n)
lizard
(Anolis carolinensis)
Reptilia MPRIP 35
  • 18 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mprip 34
  • 73.59 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-103b11.2 34
  • 66.43 (n)
MPRIP (1 of 4) 35
  • 57 (a)
OneToMany
MPRIP (4 of 4) 35
  • 51 (a)
OneToMany
MPRIP (2 of 4) 35
  • 20 (a)
OneToMany
MPRIP (3 of 4) 35
  • 12 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta osp 35
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10G8.8 35
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToMany
Species where no ortholog for MPRIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPRIP Gene

ENSEMBL:
Gene Tree for MPRIP (if available)
TreeFam:
Gene Tree for MPRIP (if available)

Paralogs for MPRIP Gene

Paralogs for MPRIP Gene

Pseudogenes.org Pseudogenes for MPRIP Gene

genes like me logo Genes that share paralogs with MPRIP: view

Variants for MPRIP Gene

Sequence variations from dbSNP and Humsavar for MPRIP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1047799 -- 17,192,173(+) CAAAC(C/G)TTCTG utr-variant-3-prime
rs1047805 -- 17,192,330(+) AGCGC(C/T)CGGGT utr-variant-3-prime
rs1047810 -- 17,192,336(+) CGGGT(C/T)TAAGA utr-variant-3-prime
rs1047814 -- 17,192,340(+) TCTAA(A/G)AAGTA utr-variant-3-prime
rs1047821 -- 17,192,393(+) CTCAA(A/G)AAAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MPRIP Gene

Variant ID Type Subtype PubMed ID
nsv962272 CNV duplication 23825009
nsv833380 CNV loss 17160897
nsv524958 CNV loss 19592680
nsv499114 OTHER inversion 21111241
nsv478946 CNV novel sequence insertion 20440878
nsv474958 CNV novel sequence insertion 20440878
nsv1996 CNV insertion 18451855
nsv1995 CNV insertion 18451855
nsv155 OTHER inversion 15895083
nsv1131131 CNV deletion 24896259
nsv1070816 CNV deletion 25765185
esv3640123 CNV loss 21293372
esv3640122 CNV loss 21293372
esv3554213 CNV deletion 23714750
esv3414266 CNV insertion 20981092
esv3346710 CNV insertion 20981092
esv3306277 CNV mobile element insertion 20981092
esv2676412 CNV deletion 23128226
esv2299362 CNV deletion 18987734

Variation tolerance for MPRIP Gene

Residual Variation Intolerance Score: 2.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPRIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MPRIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPRIP Gene

Disorders for MPRIP Gene

Relevant External Links for MPRIP

Genetic Association Database (GAD)
MPRIP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MPRIP

No disorders were found for MPRIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPRIP Gene

Publications for MPRIP Gene

  1. p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA. (PMID: 15545284) Koga Y. … Ikebe M. (J. Biol. Chem. 2005) 3 4 22 64
  2. M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells. (PMID: 16257966) Surks H.K. … Ohtani K. (J. Biol. Chem. 2005) 3 4 22 64
  3. Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA. (PMID: 14506264) Surks H.K. … Mendelsohn M.E. (J. Biol. Chem. 2003) 3 4 22 64
  4. M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion. (PMID: 18636174) Ono R. … Matsushita M. (Int. J. Mol. Med. 2008) 3 22 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for MPRIP Gene

Sources for MPRIP Gene

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