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Aliases for MPPED2 Gene

Aliases for MPPED2 Gene

  • Metallophosphoesterase Domain Containing 2 2 3 5
  • Metallophosphoesterase Domain-Containing Protein 2 3 4
  • Fetal Brain Protein 239 3 4
  • C11orf8 3 4
  • 239FB 3 4
  • Chromosome 11 Open Reading Frame 8 2
  • EC 3.1.-.- 4
  • FAM1B 4

External Ids for MPPED2 Gene

Previous HGNC Symbols for MPPED2 Gene

  • C11orf8

Previous GeneCards Identifiers for MPPED2 Gene

  • GC11M030389
  • GC11M030098

Summaries for MPPED2 Gene

Entrez Gene Summary for MPPED2 Gene

  • This gene likely encodes a metallophosphoesterase. The encoded protein may play a role a brain development. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

GeneCards Summary for MPPED2 Gene

MPPED2 (Metallophosphoesterase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is MPPED1.

UniProtKB/Swiss-Prot for MPPED2 Gene

  • Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPPED2 Gene

Genomics for MPPED2 Gene

Regulatory Elements for MPPED2 Gene

Enhancers for MPPED2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MPPED2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MPPED2 Gene

30,384,493 bp from pter
30,586,872 bp from pter
202,380 bases
Minus strand

Genomic View for MPPED2 Gene

Genes around MPPED2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPPED2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPPED2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPPED2 Gene

Proteins for MPPED2 Gene

  • Protein details for MPPED2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metallophosphoesterase MPPED2
    Protein Accession:
    Secondary Accessions:
    • D3DQZ5
    • E9PB10
    • Q59GE6

    Protein attributes for MPPED2 Gene

    294 amino acids
    Molecular mass:
    33360 Da
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Quaternary structure:
    • Homodimer.
    • Sequence=BAD92400.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MPPED2 Gene


neXtProt entry for MPPED2 Gene

Proteomics data for MPPED2 Gene at MOPED

Post-translational modifications for MPPED2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MPPED2 Gene

No data available for DME Specific Peptides for MPPED2 Gene

Domains & Families for MPPED2 Gene

Protein Domains for MPPED2 Gene

Suggested Antigen Peptide Sequences for MPPED2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0046 family.
  • Belongs to the UPF0046 family.
genes like me logo Genes that share domains with MPPED2: view

No data available for Gene Families for MPPED2 Gene

Function for MPPED2 Gene

Molecular function for MPPED2 Gene

UniProtKB/Swiss-Prot Function:
Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system (By similarity).

Enzyme Numbers (IUBMB) for MPPED2 Gene

Gene Ontology (GO) - Molecular Function for MPPED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19060904
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MPPED2: view
genes like me logo Genes that share phenotypes with MPPED2: view

Animal Model Products

miRNA for MPPED2 Gene

miRTarBase miRNAs that target MPPED2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPPED2 Gene

Localization for MPPED2 Gene

Subcellular locations from

Jensen Localization Image for MPPED2 Gene COMPARTMENTS Subcellular localization image for MPPED2 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MPPED2 Gene

Pathways & Interactions for MPPED2 Gene

SuperPathways for MPPED2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MPPED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with MPPED2: view

No data available for Pathways by source and SIGNOR curated interactions for MPPED2 Gene

Drugs & Compounds for MPPED2 Gene

No Compound Related Data Available

Transcripts for MPPED2 Gene

Unigene Clusters for MPPED2 Gene

Metallophosphoesterase domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MPPED2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - - -
SP2: - -
SP4: - - -
SP5: -
SP6: -
SP7: - - - - - -
SP8: - - -

Relevant External Links for MPPED2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPPED2 Gene

mRNA expression in normal human tissues for MPPED2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MPPED2 Gene

This gene is overexpressed in Thyroid (x4.6).

Protein differential expression in normal tissues from HIPED for MPPED2 Gene

This gene is overexpressed in Fetal Brain (34.1), Retina (11.4), Fetal heart (6.9), and Testis (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPPED2 Gene

SOURCE GeneReport for Unigene cluster for MPPED2 Gene Hs.289795

mRNA Expression by UniProt/SwissProt for MPPED2 Gene

Tissue specificity: Expressed predominantly in fetal brain.
genes like me logo Genes that share expression patterns with MPPED2: view

Protein tissue co-expression partners for MPPED2 Gene

Primer Products

Orthologs for MPPED2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MPPED2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia MPPED2 35
  • 97.85 (n)
  • 100 (a)
  • 100 (a)
(Mus musculus)
Mammalia Mpped2 35
  • 95.8 (n)
  • 99.66 (a)
Mpped2 16
Mpped2 36
  • 100 (a)
(Pan troglodytes)
Mammalia MPPED2 35
  • 99.89 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Mpped2 35
  • 95.01 (n)
  • 99.32 (a)
(Bos Taurus)
Mammalia MPPED2 36
  • 100 (a)
(Monodelphis domestica)
Mammalia MPPED2 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia MPPED2 36
  • 99 (a)
(Gallus gallus)
Aves MPPED2 35
  • 92.29 (n)
  • 99.66 (a)
  • 95 (a)
(Anolis carolinensis)
Reptilia MPPED2 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mpped2 35
  • 84.92 (n)
  • 97.62 (a)
Str.19908 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24531 35
(Danio rerio)
Actinopterygii mpped2a 35
  • 81.18 (n)
  • 91.84 (a)
wufk34e08 35
mpped2 36
  • 89 (a)
mpped2a 36
  • 93 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16717 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea C25E10.12 36
  • 42 (a)
K07C11.7 36
  • 33 (a)
T07D4.2 36
  • 34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7905 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for MPPED2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPPED2 Gene

Gene Tree for MPPED2 (if available)
Gene Tree for MPPED2 (if available)

Paralogs for MPPED2 Gene

Paralogs for MPPED2 Gene

(2) SIMAP similar genes for MPPED2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MPPED2: view

Variants for MPPED2 Gene

Sequence variations from dbSNP and Humsavar for MPPED2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11556749 - 30,536,104(-) CACAC(A/G)CTCCA intron-variant, reference, missense, utr-variant-5-prime
rs521069 -- 30,557,938(+) TGGAA(C/T)CTAAG intron-variant
rs521436 -- 30,471,657(+) AGGCT(A/T)ATAAG intron-variant
rs523257 -- 30,461,248(-) aaact(C/T)ggtat intron-variant
rs523387 -- 30,409,551(-) ATTGA(C/G)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPPED2 Gene

Variant ID Type Subtype PubMed ID
nsv832103 CNV Loss 17160897
nsv825806 CNV Loss 20364138

Variation tolerance for MPPED2 Gene

Residual Variation Intolerance Score: 21.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MPPED2 Gene

Disorders for MPPED2 Gene

Relevant External Links for MPPED2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MPPED2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPPED2 Gene

Publications for MPPED2 Gene

  1. cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region. (PMID: 8666403) Schwartz F. … Bruns G. (Genomics 1995) 2 3 4 67
  2. The 239AB gene on chromosome 22: a novel member of an ancient gene family. (PMID: 9266672) Schwartz F. … Ota T. (Gene 1997) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries. (PMID: 24556642) Zeng Z. … Shaffer J.R. (Caries Res. 2014) 3
  5. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. (PMID: 25356737) Jung J.G. … Wang T.L. (PLoS Genet. 2014) 3

Products for MPPED2 Gene

Sources for MPPED2 Gene