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MPPED2 Gene

protein-coding   GIFtS: 52
GCID: GC11M030406

Metallophosphoesterase Domain Containing 2

(Previous name: chromosome 11 open reading frame 8)
(Previous symbol: C11orf8)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Metallophosphoesterase Domain Containing 21 2     Chromosome 11 Open Reading Frame 81
C11orf81 2 3 5     Metallophosphoesterase MPPED22
239FB2 3 5     EC 3.1.-.-3
Fetal Brain Protein 2392 3     FAM1B3
Metallophosphoesterase Domain-Containing Protein 22 3     D11S302E5

External Ids:    HGNC: 11801   Entrez Gene: 7442   Ensembl: ENSG000000663827   OMIM: 6009115   UniProtKB: Q157773   

Export aliases for MPPED2 gene to outside databases

Previous GC identifers: GC11M030389 GC11M030098


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MPPED2 Gene:
This gene likely encodes a metallophosphoesterase. The encoded protein may play a role a brain development.
Alternatively spliced transcript variants have been described. (provided by RefSeq, Feb 2009)

GeneCards Summary for MPPED2 Gene:
MPPED2 (metallophosphoesterase domain containing 2) is a protein-coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is MPPED1.

UniProtKB/Swiss-Prot: MPPD2_HUMAN, Q15777
Function: Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the
nervous system (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MPPED2 gene promoter:
         Egr-3   AREB6   GATA-3   FOXO1a   Roaz   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMPPED2 promoter sequence
   Search Chromatin IP Primers for MPPED2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MPPED2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p14.1   HGNC cytogenetic band: 11p13

MPPED2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPPED2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M030406:  view genomic region     (about GC identifiers)

Start:
30,406,040 bp from pter      End:
30,608,419 bp from pter
Size:
202,380 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MPPD2_HUMAN, Q15777 (See protein sequence)
Recommended Name: Metallophosphoesterase MPPED2  
Size: 294 amino acids; 33360 Da
Cofactor: Manganese or cobalt (By similarity)
Subunit: Homodimer (By similarity)
Sequence caution: Sequence=BAD92400.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D3DQZ5 E9PB10 Q59GE6
Alternative splicing: 2 isoforms:  Q15777-1   Q15777-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MPPED2: NX_Q15777

Explore proteomics data for MPPED2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MPPED2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138871.1  NP_001575.1  

    ENSEMBL proteins: 
     ENSP00000388258   ENSP00000350833   ENSP00000432469   ENSP00000431805  

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    antibodies-online peptides for MPPED2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR004843 PEstase_dom
     IPR024201 Calcineurin-like_Pesterase

    Graphical View of Domain Structure for InterPro Entry Q15777

    ProtoNet protein and cluster: Q15777

    UniProtKB/Swiss-Prot: MPPD2_HUMAN, Q15777
    Similarity: Belongs to the UPF0046 family


    Find genes that share domains with MPPED2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPPD2_HUMAN, Q15777
    Function: Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the
    nervous system (By similarity)

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with MPPED2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MPPED2

    miRNA
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    miRTarBase miRNAs that target MPPED2:
    hsa-mir-335-5p (MIRT017152)

    Block miRNA regulation of human, mouse, rat MPPED2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MPPED2 (see all 49):
    hsa-miR-142-5p hsa-miR-549 hsa-miR-100* hsa-miR-607 hsa-miR-128 hsa-miR-200a hsa-miR-301a hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidMPPED2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    mitochondrion1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MPPED2
    Interactions:

        Search GeneGlobe Interaction Network for MPPED2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for MPPED2 (Q157773 ENSP000003508334) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP13Q156453, ENSP000001663454I2D: score=1 STRING: ENSP00000166345
    GCH1P307933I2D: score=4 
    NOS1APO750523I2D: score=3 
    CLUAP1Q96AJ13I2D: score=2 
    IKZF1Q134223I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development TAS7527372

    Find genes that share ontologies with MPPED2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MPPED2 (MPPD2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MPPED2 gene (2 alternative transcripts): 
    NM_001145399.1  NM_001584.2  

    Unigene Cluster for MPPED2:

    Metallophosphoesterase domain containing 2
    Hs.289795  [show with all ESTs]
    Unigene Representative Sequence: NM_001145399
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448418(uc001msq.3) ENST00000358117(uc001msr.3 uc009yji.3)
    ENST00000524667 ENST00000529220 ENST00000526437 ENST00000525519 ENST00000524636
    ENST00000528686
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MPPED2 (see all 49):
    hsa-miR-142-5p hsa-miR-549 hsa-miR-100* hsa-miR-607 hsa-miR-128 hsa-miR-200a hsa-miR-301a hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidMPPED2 3' UTR sequence
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MPPED2
      QuantiTect SYBR Green Assays in human, mouse, rat MPPED2
      QuantiFast Probe-based Assays in human, mouse, rat MPPED2

    Additional mRNA sequence: 

    AB209163.1 AK309809.1 AK314833.1 BC031582.1 U57911.1 

    13 DOTS entries:

    DT.413365  DT.120738544  DT.95320966  DT.120738542  DT.70100041  DT.75145591  DT.95264923  DT.100664784 
    DT.120738503  DT.101967291  DT.75107422  DT.75119014  DT.91677226 

    Selected AceView cDNA sequences (see all 80):

    AI277958 AI918798 AI951765 NM_001584 BX641852 BQ070434 AW592740 AW103109 
    AU118639 AL079387 AI700798 AI031862 AI423977 AI277414 W73009 BI758218 
    BE221934 U57911 BX116834 BQ027907 BC031582 BE218867 AI423354 AU119198 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MPPED2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:              -     -     -     -     -                             -                 -                           
    SP2:                                                                    -                 -                           
    SP3:                                                                                                                  
    SP4:                                -     -                             -                                             
    SP5:                                      -                                                                           


    ECgene alternative splicing isoforms for MPPED2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MPPED2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAGACTTA
    MPPED2 Expression
    About this image


    MPPED2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord
     
     Thyroid (Endocrine System)
    MPPED2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MPPED2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.289795

    UniProtKB/Swiss-Prot: MPPD2_HUMAN, Q15777
    Tissue specificity: Expressed predominantly in fetal brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MPPED2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mpped21 , 5 metallophosphoesterase domain containing 21, 5 95.8(n)1
    99.66(a)1
      2 (55.80 cM)5
    770151  NM_029837.11  NP_084113.11 
     1066932695 
    chicken
    (Gallus gallus)
    Aves MPPED21 metallophosphoesterase domain containing 2 92.29(n)
    99.66(a)
      421604  NM_001199420.1  NP_001186349.1 
    lizard
    (Anolis carolinensis)
    Reptilia MPPED26
    metallophosphoesterase domain containing 2
    99(a)
    1 ↔ 1
    1(59608428-59782399)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.245312 Xenopus laevis transcribed sequences 85.33(n)    48031110 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk34e082 wufk34e08 86.64(n)   336959  BC049341.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG167176
    --
    44(a)
    1 → many
    3L(9672301-9674160)
    worm
    (Caenorhabditis elegans)
    Secernentea C25E10.126
    T07D4.26
    (see all 3)
    Protein T07D4.2, isoform c
    (see all 3)
    42(a)
    34(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    V(9060494-9062440) WBGene00016101
    II(8869565-8874020) WBGene00011579


    ENSEMBL Gene Tree for MPPED2 (if available)
    TreeFam Gene Tree for MPPED2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MPPED2 gene
    MPPED12  
    2 SIMAP similar genes for MPPED2 using alignment to 4 protein entries:     MPPD2_HUMAN (see all proteins):
    C22orf1    MPPED1

    Find genes that share paralogs with MPPED2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MPPED2 (see all 3864)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs725177051,2
    C--30209170(+) ATGAC-/GT/TG 
            
    TATAT
    2 -- int10--------
    rs1512460311,2
    --30405564(+) CTGACC/TTAGAC 1 -- ds50010--------
    rs1408841951,2
    --30405573(+) ACATTA/CATTTA 1 -- ds50010--------
    rs17579931,2
    C,F,A,H--30405657(-) ATGTAG/CATGTT 1 -- ds50019Minor allele frequency- C:0.09NS EA NA WA 774
    rs1497344671,2
    --30405660(+) ATCTAC/TATTGA 1 -- ds50010--------
    rs1467302381,2
    --30405733(+) AGACAA/TGTAAT 1 -- ds50010--------
    rs777010181,2
    C--30405740(+) TAATCA/TTATTT 1 -- ds50010--------
    rs749254461,2
    C--30405741(+) AATCTG/TATTTC 1 -- ds50010--------
    rs783825061,2
    C--30405742(+) ATCTTA/CTTTCC 1 -- ds50010--------
    rs761608551,2
    C--30405743(+) TCTTAA/TTTCCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MPPED2 (30406040 - 30608419 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MPPED2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832103CNV Loss17160897
    nsv825806CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MPPED2
    DNA2.0 Custom Variant and Variant Library Synthesis for MPPED2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600911    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for MPPED2:
    Aniridia     WAGR syndrome

    Find genes that share disorders with MPPED2           About GenesLikeMe

    Genetic Association Database (GAD): MPPED2
    Human Genome Epidemiology (HuGE) Navigator: MPPED2 (2 documents)

    Export disorders for MPPED2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MPPED2 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with MPPED2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region. (PubMed id 8666403)1, 2, 3 Schwartz F.... Bruns G. (Genomics 1995)
    2. Genome-wide association and functional follow-up reveals new loci for kidney function. (PubMed id 22479191)1, 4 Pattaro C....Fox C.S. (PLoS Genet. 2012)
    3. Genome-wide association scan for childhood caries implicates novel genes. (PubMed id 21940522)1, 4 Shaffer J.R....Marazita M.L. (J. Dent. Res. 2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The 239AB gene on chromosome 22: a novel member of an ancient gene family. (PubMed id 9266672)1, 3 Schwartz F. and Ota T. (Gene 1997)
    8. A WAGR region gene between PAX-6 and FSHB expressed in fetal brain. (PubMed id 7527372)1, 2 Schwartz F.... Bruns G. (Hum. Genet. 1994)
    9. The metallophosphodiesterase Mpped2 impairs tumorigenesis in neuroblastoma. (PubMed id 22262177)1 Liguori L....Zollo M. (Cell Cycle 2012)
    10. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PubMed id 22797727)1 Okada Y....Tanaka T. (Nat. Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 744 HGNC: 1180 AceView: C11orf8 Ensembl:ENSG00000066382 euGenes: HUgn744
    ECgene: MPPED2 H-InvDB: MPPED2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MPPED2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MPPED2 gene:
    Search GeneIP for patents involving MPPED2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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