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Aliases for MPPED2 Gene

Aliases for MPPED2 Gene

  • Metallophosphoesterase Domain Containing 2 2 3 5
  • Metallophosphoesterase Domain-Containing Protein 2 3 4
  • Fetal Brain Protein 239 3 4
  • C11orf8 3 4
  • 239FB 3 4
  • Chromosome 11 Open Reading Frame 8 2
  • Metallophosphoesterase MPPED2 3
  • EC 3.1.-.- 4
  • FAM1B 4

External Ids for MPPED2 Gene

Previous HGNC Symbols for MPPED2 Gene

  • C11orf8

Previous GeneCards Identifiers for MPPED2 Gene

  • GC11M030389
  • GC11M030098

Summaries for MPPED2 Gene

Entrez Gene Summary for MPPED2 Gene

  • This gene likely encodes a metallophosphoesterase. The encoded protein may play a role a brain development. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

GeneCards Summary for MPPED2 Gene

MPPED2 (Metallophosphoesterase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is MPPED1.

UniProtKB/Swiss-Prot for MPPED2 Gene

  • Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPPED2 Gene

Genomics for MPPED2 Gene

Regulatory Elements for MPPED2 Gene

Enhancers for MPPED2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F030991 1 Ensembl ENCODE 12.1 -405.6 -405631 1.1 SOX13 SAP130 ARID4B ZNF644 YY1 NFE2 HOMEZ ZNF652 MAFK NFE2L2 MPPED2 GC11P030983 GC11P031026
GH11F030486 1.5 FANTOM5 Ensembl ENCODE 6.8 +98.4 98387 3.0 PKNOX1 ATF1 FEZF1 YY1 SLC30A9 KAT8 ZNF610 SMARCA4 ZSCAN16 MYNN MPPED2 ARL14EP FSHB ENSG00000255480 GC11P030582
GH11F030919 0.8 Ensembl ENCODE 6.4 -332.7 -332741 1.2 PKNOX1 POLR2A IKZF1 SPI1 MPPED2 LOC105376611 GC11P030983
GH11F030889 0.6 ENCODE 7.2 -302.8 -302841 1.0 ESRRA DPF2 MBD2 GATA3 CTBP1 FOSL2 RCOR1 FOS MPPED2 LOC105376611 GC11P030983
GH11F030583 0.9 ENCODE 4.6 +1.2 1222 3.8 PKNOX1 FEZF1 RAD21 GLIS2 ZNF391 ZNF263 REST TBX21 ZNF610 ZNF341 MPPED2 LOC105376609
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MPPED2 on UCSC Golden Path with GeneCards custom track

Promoters for MPPED2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001767628 1372 2601 CTCF SUZ12 ZIC2 RAD21 HIC1 ZNF324 ZFHX2 GLIS2 ZBTB48 POLR2A

Genomic Location for MPPED2 Gene

Chromosome:
11
Start:
30,384,493 bp from pter
End:
30,586,872 bp from pter
Size:
202,380 bases
Orientation:
Minus strand

Genomic View for MPPED2 Gene

Genes around MPPED2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPPED2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPPED2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPPED2 Gene

Proteins for MPPED2 Gene

  • Protein details for MPPED2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15777-MPPD2_HUMAN
    Recommended name:
    Metallophosphoesterase MPPED2
    Protein Accession:
    Q15777
    Secondary Accessions:
    • D3DQZ5
    • E9PB10
    • Q59GE6

    Protein attributes for MPPED2 Gene

    Size:
    294 amino acids
    Molecular mass:
    33360 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=BAD92400.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MPPED2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPPED2 Gene

Post-translational modifications for MPPED2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MPPED2 Gene

Domains & Families for MPPED2 Gene

Suggested Antigen Peptide Sequences for MPPED2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15777

UniProtKB/Swiss-Prot:

MPPD2_HUMAN :
  • Belongs to the UPF0046 family.
Family:
  • Belongs to the UPF0046 family.
genes like me logo Genes that share domains with MPPED2: view

No data available for Gene Families for MPPED2 Gene

Function for MPPED2 Gene

Molecular function for MPPED2 Gene

UniProtKB/Swiss-Prot Function:
Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system (By similarity).

Enzyme Numbers (IUBMB) for MPPED2 Gene

Gene Ontology (GO) - Molecular Function for MPPED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19060904
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MPPED2: view
genes like me logo Genes that share phenotypes with MPPED2: view

Animal Model Products

miRNA for MPPED2 Gene

miRTarBase miRNAs that target MPPED2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPPED2 Gene

Localization for MPPED2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPPED2 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MPPED2 Gene

Pathways & Interactions for MPPED2 Gene

SuperPathways for MPPED2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MPPED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development TAS 7527372
genes like me logo Genes that share ontologies with MPPED2: view

No data available for Pathways by source and SIGNOR curated interactions for MPPED2 Gene

Transcripts for MPPED2 Gene

Unigene Clusters for MPPED2 Gene

Metallophosphoesterase domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPPED2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - - -
SP2: - -
SP3:
SP4: - - -
SP5: -
SP6: -
SP7: - - - - - -
SP8: - - -

Relevant External Links for MPPED2 Gene

GeneLoc Exon Structure for
MPPED2
ECgene alternative splicing isoforms for
MPPED2

Expression for MPPED2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MPPED2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MPPED2 Gene

This gene is overexpressed in Thyroid (x4.6).

Protein differential expression in normal tissues from HIPED for MPPED2 Gene

This gene is overexpressed in Fetal Brain (34.1), Retina (11.4), Fetal heart (6.9), and Testis (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MPPED2 Gene



Protein tissue co-expression partners for MPPED2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MPPED2 Gene:

MPPED2

SOURCE GeneReport for Unigene cluster for MPPED2 Gene:

Hs.289795

mRNA Expression by UniProt/SwissProt for MPPED2 Gene:

Q15777-MPPD2_HUMAN
Tissue specificity: Expressed predominantly in fetal brain.
genes like me logo Genes that share expression patterns with MPPED2: view

Primer Products

Orthologs for MPPED2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MPPED2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MPPED2 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MPPED2 34 35
  • 99.89 (n)
oppossum
(Monodelphis domestica)
Mammalia MPPED2 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MPPED2 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MPPED2 34 35
  • 97.85 (n)
mouse
(Mus musculus)
Mammalia Mpped2 34 16 35
  • 95.8 (n)
rat
(Rattus norvegicus)
Mammalia Mpped2 34
  • 95.01 (n)
chicken
(Gallus gallus)
Aves MPPED2 34 35
  • 92.29 (n)
lizard
(Anolis carolinensis)
Reptilia MPPED2 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mpped2 34
  • 84.92 (n)
Str.19908 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24531 34
zebrafish
(Danio rerio)
Actinopterygii mpped2 35
  • 89 (a)
OneToMany
mpped2a 34 35
  • 81.18 (n)
wufk34e08 34
fruit fly
(Drosophila melanogaster)
Insecta CG16717 35
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C25E10.12 35
  • 42 (a)
ManyToMany
T07D4.2 35
  • 34 (a)
ManyToMany
K07C11.7 35
  • 33 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7905 34
Species where no ortholog for MPPED2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPPED2 Gene

ENSEMBL:
Gene Tree for MPPED2 (if available)
TreeFam:
Gene Tree for MPPED2 (if available)

Paralogs for MPPED2 Gene

Paralogs for MPPED2 Gene

(2) SIMAP similar genes for MPPED2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MPPED2: view

Variants for MPPED2 Gene

Sequence variations from dbSNP and Humsavar for MPPED2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1009074 -- 30,448,116(+) TGAAT(C/G)AGCAT intron-variant
rs1011002 -- 30,463,858(+) tatat(A/G)tatat intron-variant
rs10160289 -- 30,514,978(+) taacc(C/T)cagct intron-variant
rs10160329 -- 30,545,902(+) cttgt(C/T)gccca intron-variant
rs10219386 -- 30,489,961(+) AAGAG(A/C)CTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPPED2 Gene

Variant ID Type Subtype PubMed ID
esv3428586 CNV insertion 20981092
esv3444153 CNV insertion 20981092
esv3625817 CNV loss 21293372
nsv553947 CNV gain 21841781
nsv825806 CNV loss 20364138
nsv832103 CNV loss 17160897

Variation tolerance for MPPED2 Gene

Residual Variation Intolerance Score: 21.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPPED2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MPPED2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPPED2 Gene

Disorders for MPPED2 Gene

Relevant External Links for MPPED2

Genetic Association Database (GAD)
MPPED2
Human Genome Epidemiology (HuGE) Navigator
MPPED2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MPPED2

No disorders were found for MPPED2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPPED2 Gene

Publications for MPPED2 Gene

  1. cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region. (PMID: 8666403) Schwartz F. … Bruns G. (Genomics 1995) 2 3 4 64
  2. Genome-wide association and functional follow-up reveals new loci for kidney function. (PMID: 22479191) Pattaro C. … Fox C.S. (PLoS Genet. 2012) 3 46 64
  3. Genome-wide association scan for childhood caries implicates novel genes. (PMID: 21940522) Shaffer J.R. … Marazita M.L. (J. Dent. Res. 2011) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64

Products for MPPED2 Gene

Sources for MPPED2 Gene

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