Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MPPED2 Gene

protein-coding   GIFtS: 52
GCID: GC11M030389

Metallophosphoesterase Domain Containing 2

(Previous name: chromosome 11 open reading frame 8)
(Previous symbol: C11orf8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Metallophosphoesterase Domain Containing 21 2     Chromosome 11 Open Reading Frame 81
C11orf81 2 3 5     Metallophosphoesterase MPPED22
239FB2 3 5     EC 3.1.-.-3
Fetal Brain Protein 2392 3     FAM1B3
Metallophosphoesterase Domain-Containing Protein 22 3     D11S302E5

External Ids:    HGNC: 11801   Entrez Gene: 7442   Ensembl: ENSG000000663827   OMIM: 6009115   UniProtKB: Q157773   

Export aliases for MPPED2 gene to outside databases

Previous GC identifer: GC11M030098


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MPPED2 Gene:
This gene likely encodes a metallophosphoesterase. The encoded protein may play a role a brain development.
Alternatively spliced transcript variants have been described. (provided by RefSeq, Feb 2009)

GeneCards Summary for MPPED2 Gene: 
MPPED2 (metallophosphoesterase domain containing 2) is a protein-coding gene. Diseases associated with MPPED2 include wagr syndrome, and aniridia. GO annotations related to this gene include hydrolase activity and metal ion binding. An important paralog of this gene is MPPED1.

UniProtKB/Swiss-Prot: MPPD2_HUMAN, Q15777
Function: Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the
nervous system (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MPPED2 gene promoter:
         Egr-3   AREB6   GATA-3   FOXO1a   Roaz   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMPPED2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MPPED2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPPED2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p14.1   HGNC cytogenetic band: 11p13

MPPED2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPPED2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M030389:  view genomic region     (about GC identifiers)

Start:
30,406,040 bp from pter      End:
30,608,419 bp from pter
Size:
202,380 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MPPD2_HUMAN, Q15777 (See protein sequence)
Recommended Name: Metallophosphoesterase MPPED2  
Size: 294 amino acids; 33360 Da
Cofactor: Manganese or cobalt (By similarity)
Subunit: Homodimer (By similarity)
Sequence caution: Sequence=BAD92400.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D3DQZ5 E9PB10 Q59GE6
Alternative splicing: 2 isoforms:  Q15777-1   Q15777-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MPPED2: NX_Q15777

Explore proteomics data for MPPED2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15777

  • MPPED2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MPPED2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001138871.1  NP_001575.1  

    ENSEMBL proteins: 
     ENSP00000388258   ENSP00000350833   ENSP00000432469   ENSP00000431805  

    Human Recombinant Protein Products for MPPED2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MPPED2
    OriGene Protein Over-expression Lysate for MPPED2
    OriGene MassSpec for MPPED2 
    OriGene Custom Protein Services for MPPED2
    GenScript Custom Purified and Recombinant Proteins Services for MPPED2
    Novus Biologicals MPPED2 Proteins
    Novus Biologicals MPPED2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MPPED2 


    MPPED2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MPPED2
    GenScript Custom Superior Antibodies Services for MPPED2
    Novus Biologicals MPPED2 Antibodies
    Abcam antibodies for MPPED2
    Cloud-Clone Corp. Antibodies for MPPED2 
    Search ThermoFisher Antibodies for MPPED2
    LSBio Antibodies in human, mouse, rat for MPPED2 

    Assay Products for MPPED2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MPPED2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MPPED2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MPPED2 
    Cloud-Clone Corp. CLIAs for MPPED2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR004843 Metallo_PEstase_dom
     IPR024201 Calcineurin-like_Pesterase

    Graphical View of Domain Structure for InterPro Entry Q15777

    ProtoNet protein and cluster: Q15777

    UniProtKB/Swiss-Prot: MPPD2_HUMAN, Q15777
    Similarity: Belongs to the UPF0046 family


    MPPED2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPPD2_HUMAN, Q15777
    Function: Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the
    nervous system (By similarity)

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity IEA--
    GO:0046872metal ion binding IEA--
         
    MPPED2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MPPED2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MPPED2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MPPED2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MPPED2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPPED2
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate MPPED2 (see all 49):
    hsa-miR-142-5p hsa-miR-549 hsa-miR-100* hsa-miR-607 hsa-miR-128 hsa-miR-200a hsa-miR-301a hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidMPPED2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MPPED2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPPED2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MPPED2
    Sirion Biotech Customized adenovirus for overexpression of MPPED2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MPPED2 (see all 14)
    OriGene ORF clones in mouse, rat for MPPED2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MPPED2 (NM_001584)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPPED2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPPED2
    Sirion Biotech Customized lentivirus for stable overexpression of MPPED2 
                         Customized lentivirus expression plasmids for stable overexpression of MPPED2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MPPED2
    Search LifeMap BioReagents cell lines for MPPED2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPPED2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MPPED2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/7 Interacting proteins for MPPED2 (Q157773 ENSP000003508334) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP13Q156453, ENSP000001663454I2D: score=1 STRING: ENSP00000166345
    GCH1P307933I2D: score=4 
    NOS1APO750523I2D: score=3 
    CLUAP1Q96AJ13I2D: score=2 
    IKZF1Q134223I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development TAS7527372

    MPPED2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MPPED2 (MPPD2)

    Search CenterWatch for drugs/clinical trials and news about MPPED2 / MPPD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MPPED2 gene (2 alternative transcripts): 
    NM_001145399.1  NM_001584.2  

    Unigene Cluster for MPPED2:

    Metallophosphoesterase domain containing 2
    Hs.289795  [show with all ESTs]
    Unigene Representative Sequence: NM_001145399
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448418(uc001msq.3) ENST00000358117(uc001msr.3 uc009yji.3)
    ENST00000524667 ENST00000529220 ENST00000526437 ENST00000525519 ENST00000524636
    ENST00000528686
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPPED2
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate MPPED2 (see all 49):
    hsa-miR-142-5p hsa-miR-549 hsa-miR-100* hsa-miR-607 hsa-miR-128 hsa-miR-200a hsa-miR-301a hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidMPPED2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MPPED2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPPED2
    Clone
    Products:
         
    OriGene clones in human, mouse for MPPED2 (see all 14)
    OriGene ORF clones in mouse, rat for MPPED2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MPPED2 (NM_001584)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPPED2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPPED2
    Sirion Biotech Customized lentivirus for stable overexpression of MPPED2 
                         Customized lentivirus expression plasmids for stable overexpression of MPPED2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MPPED2
    OriGene qSTAR qPCR primer pairs in human, mouse for MPPED2
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MPPED2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPPED2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPPED2

    Additional mRNA sequence: 

    AB209163.1 AK309809.1 AK314833.1 BC031582.1 U57911.1 

    13 DOTS entries:

    DT.413365  DT.120738544  DT.95320966  DT.120738542  DT.70100041  DT.75145591  DT.95264923  DT.100664784 
    DT.120738503  DT.101967291  DT.75107422  DT.75119014  DT.91677226 

    24/80 AceView cDNA sequences (see all 80):

    W73009 AI625178 AU119198 AI918798 AL079387 AU118639 BE221934 AI423354 
    BX116834 AW103109 AI700798 AI951765 U57911 BQ070434 BC031582 BI758218 
    AI277958 AW592740 AI423977 BE218867 NM_001584 BQ027907 AI277414 BX641852 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MPPED2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:              -     -     -     -     -                             -                 -                           
    SP2:                                                                    -                 -                           
    SP3:                                                                                                                  
    SP4:                                -     -                             -                                             
    SP5:                                      -                                                                           


    ECgene alternative splicing isoforms for MPPED2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MPPED2 expression in normal human tissues (normalized intensities)      MPPED2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAGACTTA
    MPPED2 Expression
    About this image


    MPPED2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             superior temporal gyrus   
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord
     
     Thyroid (Endocrine System)

    See MPPED2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MPPED2

    SOURCE GeneReport for Unigene cluster: Hs.289795

    UniProtKB/Swiss-Prot: MPPD2_HUMAN, Q15777
    Tissue specificity: Expressed predominantly in fetal brain

        SABiosciences Custom PCR Arrays for MPPED2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MPPED2
    OriGene qSTAR qPCR primer pairs in human, mouse for MPPED2
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MPPED2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPPED2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPPED2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPPED2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MPPED2 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mpped21 , 5 metallophosphoesterase domain containing 21, 5 95.8(n)1
    99.66(a)1
      2 (55.80 cM)5
    770151  NM_001143683.11  NP_001137155.11 
     1066932695 
    chicken
    (Gallus gallus)
    Aves MPPED21 metallophosphoesterase domain containing 2 92.29(n)
    99.66(a)
      421604  NM_001199420.1  NP_001186349.1 
    lizard
    (Anolis carolinensis)
    Reptilia MPPED26
    Uncharacterized protein
    99(a)
    1 ↔ 1
    1(59608428-59782399)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.245312 Xenopus laevis transcribed sequences 85.33(n)    48031110 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk34e082 wufk34e08 86.64(n)   336959  BC049341.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG167176
    --
    44(a)
    1 → many
    3L(9672301-9674160)
    worm
    (Caenorhabditis elegans)
    Secernentea C25E10.126
    K07C11.76
    (see all 3)
    UPF0046 protein K07C11.7
    (see all 3)
    43(a)
    34(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    V(9060494-9062440)
    V(8207628-8213968)


    ENSEMBL Gene Tree for MPPED2 (if available)
    TreeFam Gene Tree for MPPED2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MPPED2 gene
    MPPED12  
    2 SIMAP similar genes for MPPED2 using alignment to 4 protein entries:     MPPD2_HUMAN (see all proteins):
    C22orf1    MPPED1

    MPPED2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3864 SNPs in MPPED2 are shown (see all 3864)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs725177051,2
    C--30209170(+) ATGAC-/GT/TG 
            
    TATAT
    2 -- int10--------
    rs1512460311,2
    --30405564(+) CTGACC/TTAGAC 1 -- ds50010--------
    rs1408841951,2
    --30405573(+) ACATTA/CATTTA 1 -- ds50010--------
    rs17579931,2
    C,F,A,H--30405657(-) ATGTAG/CATGTT 1 -- ds50019Minor allele frequency- C:0.09NS EA NA WA 774
    rs1497344671,2
    --30405660(+) ATCTAC/TATTGA 1 -- ds50010--------
    rs1467302381,2
    --30405733(+) AGACAA/TGTAAT 1 -- ds50010--------
    rs777010181,2
    C--30405740(+) TAATCA/TTATTT 1 -- ds50010--------
    rs749254461,2
    C--30405741(+) AATCTG/TATTTC 1 -- ds50010--------
    rs783825061,2
    C--30405742(+) ATCTTA/CTTTCC 1 -- ds50010--------
    rs761608551,2
    C--30405743(+) TCTTAA/TTTCCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MPPED2 (30406040 - 30608419 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MPPED2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832103CNV Loss17160897
    nsv825806CNV Loss20364138

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MPPED2
    DNA2.0 Custom Variant and Variant Library Synthesis for MPPED2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600911    OMIM disorders: --

    8 diseases for MPPED2:    About MalaCards
    wagr syndrome    aniridia    nephroblastoma    papillary thyroid carcinoma
    wilms tumor    mental retardation    thyroiditis    neuroblastoma

    2 diseases from the University of Copenhagen DISEASES database for MPPED2:
    Aniridia     WAGR syndrome

    MPPED2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MPPED2
    Human Genome Epidemiology (HuGE) Navigator: MPPED2 (2 documents)

    Export disorders for MPPED2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MPPED2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with MPPED2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region. (PubMed id 8666403)1, 2, 3 Schwartz F.... Bruns G. (1995)
    2. Genome-wide association and functional follow-up revea ls new loci for kidney function. (PubMed id 22479191)1, 4 Pattaro C....Fox C.S. (2012)
    3. Genome-wide association scan for childhood caries impl icates novel genes. (PubMed id 21940522)1, 4 Shaffer J.R....Marazita M.L. (2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The 239AB gene on chromosome 22: a novel member of an ancient gene family. (PubMed id 9266672)1, 3 Schwartz F. and Ota T. (1997)
    8. A WAGR region gene between PAX-6 and FSHB expressed in fetal brain. (PubMed id 7527372)1, 2 Schwartz F.... Bruns G. (1994)
    9. The metallophosphodiesterase Mpped2 impairs tumorigene sis in neuroblastoma. (PubMed id 22262177)1 Liguori L....Zollo M. (2012)
    10. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PubMed id 22797727)1 Okada Y....Tanaka T. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 744 HGNC: 1180 AceView: C11orf8 Ensembl:ENSG00000066382 euGenes: HUgn744
    ECgene: MPPED2 H-InvDB: MPPED2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MPPED2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MPPED2 gene:
    Search GeneIP for patents involving MPPED2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MPPED2  
     OriGene qPCR primer pairs and template standards for MPPED2   OriGene Protein Over-expression Lysate for MPPED2  
     OriGene MassSpec something-or-other for MPPED2   OriGene clones in human, mouse for MPPED2  
     OriGene qSTAR qPCR primer pairs in human, mouse for MPPED2   OriGene Purified Protein for MPPED2  
     OriGene ORF clones in mouse, rat for MPPED2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MPPED2   OriGene Custom Protein Services for MPPED2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MPPED2
     QIAGEN SeqTarget long-range PCR primers for resequencing MPPED2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPPED2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPPED2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPPED2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPPED2
     GenScript Custom Purified and Recombinant Proteins Services for MPPED2 GenScript cDNA clones with any tag delivered in your preferred vector for MPPED2
     GenScript Custom Assay Services for MPPED2 GenScript Custom Superior Antibodies Services for MPPED2
     GenScript Custom overexpressing Cell Line Services for MPPED2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MPPED2 promoter
     Search Chromatin IP Primers for MPPED2
     RT2 qPCR Primer Assay in human, mouse / rat MPPED2
     Search GNC Networks for MPPED2
     SABiosciences Custom PCR Arrays for MPPED2
     Search Tocris compounds for MPPED2 (MPPD2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MPPED2 antibodies
     MPPED2 proteins
     MPPED2 lysates
     Antibodies for MPPED2
     See all of Abcam's Antibodies, Kits and Proteins for MPPED2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MPPED2
     Antibodies for MPPED2
     ELISAs for MPPED2
     CLIAs for MPPED2
     Search LifeMap BioReagents cell lines for MPPED2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPPED2
     SwitchGear 3'UTR luciferase reporter plasmids for MPPED2
     SwitchGear Promoter luciferase reporter plasmids for MPPED2
     Search ThermoFisher Antibodies for MPPED2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPPED2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MPPED2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MPPED2
    Customized:
     lentivirus for stable overexpression of MPPED2
     lentivirus expression plasmids for stable overexpression of MPPED2
     adenovirus for overexpression of MPPED2
     LSBio Antibodies in human, mouse, rat for MPPED2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MPPED2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4