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Aliases for MPPED1 Gene

Aliases for MPPED1 Gene

  • Metallophosphoesterase Domain Containing 1 2 3
  • C22orf1 3 4 6
  • 239AB 3 4 6
  • Adult Brain Protein 239 3 4
  • FAM1A 3 4
  • Metallophosphoesterase Domain-Containing Protein 1 3
  • Chromosome 22 Open Reading Frame 1 2
  • EC 3.1.-.- 4

External Ids for MPPED1 Gene

Previous Symbols for MPPED1 Gene

  • C22orf1

Summaries for MPPED1 Gene

GeneCards Summary for MPPED1 Gene

MPPED1 (Metallophosphoesterase Domain Containing 1) is a Protein Coding gene. Diseases associated with MPPED1 include wagr syndrome. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is MPPED2.

UniProtKB/Swiss-Prot for MPPED1 Gene

  • May have metallophosphoesterase activity (in vitro).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPPED1 Gene

Genomics for MPPED1 Gene

Genomic Location for MPPED1 Gene

Start:
43,411,196 bp from pter
End:
43,507,848 bp from pter
Size:
96,653 bases
Orientation:
Plus strand

Genomic View for MPPED1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPPED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPPED1 Gene

Regulatory Elements for MPPED1 Gene

Proteins for MPPED1 Gene

  • Protein details for MPPED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15442-MPPD1_HUMAN
    Recommended name:
    Metallophosphoesterase domain-containing protein 1
    Protein Accession:
    O15442
    Secondary Accessions:
    • A8K159
    • B7Z2S9
    • Q8N361

    Protein attributes for MPPED1 Gene

    Size:
    326 amino acids
    Molecular mass:
    37207 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC51673.2; Type=Frameshift; Positions=20; Evidence={ECO:0000305};

    Alternative splice isoforms for MPPED1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPPED1 Gene

Proteomics data for MPPED1 Gene at MOPED

Post-translational modifications for MPPED1 Gene

No Post-translational modifications

Other Protein References for MPPED1 Gene

No data available for DME Specific Peptides for MPPED1 Gene

Domains for MPPED1 Gene

Protein Domains for MPPED1 Gene

UniProtKB/Swiss-Prot:

MPPD1_HUMAN
Family:
  • Belongs to the UPF0046 family.:
    • O15442
genes like me logo Genes that share domains with MPPED1: view

No data available for Gene Families for MPPED1 Gene

Function for MPPED1 Gene

Molecular function for MPPED1 Gene

UniProtKB/Swiss-Prot Function: May have metallophosphoesterase activity (in vitro).

Enzyme Numbers (IUBMB) for MPPED1 Gene

Gene Ontology (GO) - Molecular Function for MPPED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MPPED1: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MPPED1 Gene

Localization for MPPED1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MPPED1 Gene COMPARTMENTS Subcellular localization image for MPPED1 gene
Compartment Confidence
extracellular 2
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MPPED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MPPED1: view

Pathways for MPPED1 Gene

SuperPathways for MPPED1 Gene

No Data Available

Interacting Proteins for MPPED1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000388137%0d%0a9606.ENSP00000355593%0d%0a
Selected Interacting proteins: O15442-MPPD1_HUMAN ENSP00000388137 for MPPED1 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for MPPED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with MPPED1: view

No data available for Pathways by source for MPPED1 Gene

Transcripts for MPPED1 Gene

mRNA/cDNA for MPPED1 Gene

(2) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MPPED1 Gene

Metallophosphoesterase domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MPPED1 Gene

No ASD Table

Relevant External Links for MPPED1 Gene

GeneLoc Exon Structure for
MPPED1
ECgene alternative splicing isoforms for
MPPED1

Expression for MPPED1 Gene

mRNA expression in normal human tissues for MPPED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MPPED1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (10.6), Brain - Cortex (10.3), Brain - Anterior cingulate cortex (BA24) (9.9), Brain - Hippocampus (5.9), and Liver (4.6).

SOURCE GeneReport for Unigene cluster for MPPED1 Gene Hs.159538

mRNA Expression by UniProt/SwissProt for MPPED1 Gene

O15442-MPPD1_HUMAN
Tissue specificity: Expressed predominantly in adult brain
genes like me logo Genes that share expressions with MPPED1: view

Orthologs for MPPED1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MPPED1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MPPED1 36
  • 93.15 (n)
  • 99.08 (a)
MPPED1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mpped1 36
  • 89.98 (n)
  • 98.16 (a)
Mpped1 16
Mpped1 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MPPED1 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 97 (a)
OneToMany
-- 37
  • 73 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mpped1 36
  • 91.21 (n)
  • 98.47 (a)
chicken
(Gallus gallus)
Aves MPPED1 36
  • 80.57 (n)
  • 97.02 (a)
MPPED1 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MPPED1 37
  • 96 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii MPPED1 37
  • 88 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004891 36
  • 54.55 (n)
  • 48.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16717 36
  • 58.58 (n)
  • 55.74 (a)
CG16717 37
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C25E10.12 37
  • 41 (a)
ManyToMany
K07C11.7 37
  • 36 (a)
ManyToMany
T07D4.2 36
  • 51.63 (n)
  • 49.62 (a)
T07D4.2 37
  • 32 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 43 (a)
OneToMany
Species with no ortholog for MPPED1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MPPED1 Gene

ENSEMBL:
Gene Tree for MPPED1 (if available)
TreeFam:
Gene Tree for MPPED1 (if available)

Paralogs for MPPED1 Gene

Paralogs for MPPED1 Gene

Selected SIMAP similar genes for MPPED1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MPPED1: view

Variants for MPPED1 Gene

Sequence variations from dbSNP and Humsavar for MPPED1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs20195 -- 43,461,434(-) tccga(A/G)gagca intron-variant
rs80318 -- 43,467,417(-) CAGGC(A/G)GGAGA intron-variant
rs135031 -- 43,463,055(-) ccaaa(C/T)tctag intron-variant
rs135032 -- 43,460,759(-) tgttg(A/G)ggatg intron-variant
rs135034 -- 43,458,506(-) gagat(A/G)gagac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPPED1 Gene

Variant ID Type Subtype PubMed ID
dgv4996n71 CNV Loss 21882294
nsv508739 CNV Insertion 20534489
nsv915246 CNV Loss 21882294
nsv915248 CNV Loss 21882294
dgv4997n71 CNV Loss 21882294
nsv915251 CNV Loss 21882294
nsv428392 CNV Gain+Loss 18775914
esv2724308 CNV Deletion 23290073
esv1484276 CNV Insertion 17803354
esv2663442 CNV Deletion 23128226
nsv459892 CNV Gain 19166990
nsv471205 CNV Gain 18288195
esv2724309 CNV Deletion 23290073
esv2393908 CNV Deletion 18987734
esv2657732 CNV Deletion 23128226
esv2470453 CNV Insertion 19546169
esv2724310 CNV Deletion 23290073
esv2670249 CNV Deletion 23128226
dgv783e201 CNV Deletion 23290073
esv2724312 CNV Deletion 23290073
esv2671679 CNV Deletion 23128226
esv2724314 CNV Deletion 23290073
esv2678841 CNV Deletion 23128226
esv2724315 CNV Deletion 23290073

Relevant External Links for MPPED1 Gene

HapMap Linkage Disequilibrium report
MPPED1

Disorders for MPPED1 Gene

(1) MalaCards Diseases for MPPED1 Gene

Search for MPPED1 Gene in MalaCards »

Relevant External Links for MPPED1

Genetic Association Database (GAD)
MPPED1
Human Genome Epidemiology (HuGE) Navigator
MPPED1
genes like me logo Genes that share disorders with MPPED1: view

No data available for UniProtKB/Swiss-Prot for MPPED1 Gene

Publications for MPPED1 Gene

  1. The 239AB gene on chromosome 22: a novel member of an ancient gene family. (PMID: 9266672) Schwartz F. … Ota T. (Gene 1997) 2 3 4
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for MPPED1 Gene

Sources for MPPED1 Gene

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