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Aliases for MPPE1 Gene

Aliases for MPPE1 Gene

  • Metallophosphoesterase 1 2 3
  • Post-GPI Attachment To Proteins Factor 5 3 4
  • PGAP5 3 4
  • Metallo Phosphoesterase 3
  • EC 3.1.-.- 4

External Ids for MPPE1 Gene

Previous GeneCards Identifiers for MPPE1 Gene

  • GC18P012145
  • GC18M011940
  • GC18M011873
  • GC18M011883
  • GC18M012550
  • GC18M012841
  • GC18M013241

Summaries for MPPE1 Gene

GeneCards Summary for MPPE1 Gene

MPPE1 (Metallophosphoesterase 1) is a Protein Coding gene. GO annotations related to this gene include manganese ion binding and GPI anchor binding.

UniProtKB/Swiss-Prot for MPPE1 Gene

  • Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPPE1 Gene

Genomics for MPPE1 Gene

Regulatory Elements for MPPE1 Gene

Genomic Location for MPPE1 Gene

Start:
11,882,622 bp from pter
End:
11,909,223 bp from pter
Size:
26,602 bases
Orientation:
Minus strand

Genomic View for MPPE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPPE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPPE1 Gene

Proteins for MPPE1 Gene

  • Protein details for MPPE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53F39-MPPE1_HUMAN
    Recommended name:
    Metallophosphoesterase 1
    Protein Accession:
    Q53F39
    Secondary Accessions:
    • B0YJ39
    • B0YJ40
    • B0YJ41
    • B5ME53
    • B7WNJ3
    • D3DUI5
    • D3DUI7
    • Q6GMP1
    • Q8TAD6
    • Q8TE26
    • Q8WZ32
    • Q9BU58
    • Q9H958
    • Q9HAI4

    Protein attributes for MPPE1 Gene

    Size:
    396 amino acids
    Molecular mass:
    45141 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.;
    Quaternary structure:
    • Interacts with GPI-anchor proteins. Interacts with TMED10.
    SequenceCaution:
    • Sequence=BAB13863.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14378.1; Type=Frameshift; Positions=201; Evidence={ECO:0000305};

    Alternative splice isoforms for MPPE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPPE1 Gene

Proteomics data for MPPE1 Gene at MOPED

Post-translational modifications for MPPE1 Gene

  • Ubiquitination at Lys289
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MPPE1 Gene

Domains for MPPE1 Gene

Protein Domains for MPPE1 Gene

Suggested Antigen Peptide Sequences for MPPE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53F39

UniProtKB/Swiss-Prot:

MPPE1_HUMAN :
  • Q53F39
Domain:
  • The di-lysine motif (KxKxx) acts as an endoplasmic reticulum retrieval signal.
Family:
  • Belongs to the metallophosphoesterase superfamily. MPPE1 family.
genes like me logo Genes that share domains with MPPE1: view

No data available for Gene Families for MPPE1 Gene

Function for MPPE1 Gene

Molecular function for MPPE1 Gene

UniProtKB/Swiss-Prot Function: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.

Enzyme Numbers (IUBMB) for MPPE1 Gene

Gene Ontology (GO) - Molecular Function for MPPE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008081 phosphoric diester hydrolase activity ISS --
GO:0016787 hydrolase activity --
GO:0030145 manganese ion binding ISS --
GO:0034235 GPI anchor binding ISS --
genes like me logo Genes that share ontologies with MPPE1: view

miRNA for MPPE1 Gene

miRTarBase miRNAs that target MPPE1

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MPPE1 Gene

Localization for MPPE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPPE1 Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Note=Also localizes to endoplasmic reticulum exit site.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MPPE1 Gene COMPARTMENTS Subcellular localization image for MPPE1 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 3
plasma membrane 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MPPE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment ISS --
GO:0005794 Golgi apparatus IDA --
GO:0005801 cis-Golgi network ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MPPE1: view

Pathways for MPPE1 Gene

SuperPathways for MPPE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MPPE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006506 GPI anchor biosynthetic process ISS --
GO:0006888 ER to Golgi vesicle-mediated transport ISS --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with MPPE1: view

No data available for Pathways by source for MPPE1 Gene

Transcripts for MPPE1 Gene

Unigene Clusters for MPPE1 Gene

Metallophosphoesterase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MPPE1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6:
SP7: - - - - - - -
SP8:
SP9: - - - - - - -
SP10: - - - - - - - - - -
SP11:
SP12:
SP13: - - - - - - - -
SP14: - - - - - - - - - - -
SP15: - - -
SP16: - - - - - - - - - -
SP17: - - - - - - - - - -
SP18: -
SP19: - - - - - - - - -
SP20:
SP21: - - - - -
SP22: - - - - - - -
SP23: -
SP24:
SP25: -

ExUns: 13e ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c · 23d
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - -
SP6: - - - - -
SP7: -
SP8: -
SP9:
SP10: -
SP11: - -
SP12: - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: - -
SP21:
SP22: -
SP23:
SP24:
SP25:

Relevant External Links for MPPE1 Gene

GeneLoc Exon Structure for
MPPE1
ECgene alternative splicing isoforms for
MPPE1

Expression for MPPE1 Gene

mRNA expression in normal human tissues for MPPE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MPPE1 Gene

This gene is overexpressed in Whole Blood (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPPE1 Gene

SOURCE GeneReport for Unigene cluster for MPPE1 Gene Hs.712666

mRNA Expression by UniProt/SwissProt for MPPE1 Gene

Q53F39-MPPE1_HUMAN
Tissue specificity: Expressed in brain.
genes like me logo Genes that share expressions with MPPE1: view

Orthologs for MPPE1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MPPE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MPPE1 35
  • 99.66 (n)
  • 99.49 (a)
MPPE1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MPPE1 35
  • 76.03 (n)
  • 71.14 (a)
MPPE1 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MPPE1 35
  • 81.79 (n)
  • 79.49 (a)
MPPE1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mppe1 35
  • 78.41 (n)
  • 75.39 (a)
Mppe1 16
Mppe1 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MPPE1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MPPE1 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mppe1 35
  • 77.89 (n)
  • 74.61 (a)
chicken
(Gallus gallus)
Aves MPPE1 35
  • 70.43 (n)
  • 66.93 (a)
MPPE1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mppe1 35
  • 65.37 (n)
  • 62.78 (a)
zebrafish
(Danio rerio)
Actinopterygii mppe1 35
  • 59.49 (n)
  • 56.4 (a)
mppe1 36
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009304 35
  • 52.91 (n)
  • 44.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8455 35
  • 51.28 (n)
  • 43.79 (a)
CG8455 36
  • 40 (a)
OneToOne
CG8455 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea B0511.13 35
  • 46.84 (n)
  • 38.92 (a)
B0511.13 36
  • 27 (a)
OneToOne
B0511.13 37
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC1 36
  • 16 (a)
OneToOne
CDC1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for MPPE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPPE1 Gene

ENSEMBL:
Gene Tree for MPPE1 (if available)
TreeFam:
Gene Tree for MPPE1 (if available)

Paralogs for MPPE1 Gene

Pseudogenes.org Pseudogenes for MPPE1 Gene

genes like me logo Genes that share paralogs with MPPE1: view

No data available for Paralogs for MPPE1 Gene

Variants for MPPE1 Gene

Sequence variations from dbSNP and Humsavar for MPPE1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs592941 -- 11,887,537(+) TAAGG(A/C)AGAGG intron-variant
rs593713 -- 11,887,658(+) ATACG(A/G)TTTTA intron-variant
rs602336 -- 11,900,832(-) cctcc(C/T)gggtt intron-variant
rs602785 -- 11,900,735(-) agaga(C/T)ggggt intron-variant
rs603762 -- 11,904,091(-) AATTC(A/C)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPPE1 Gene

Variant ID Type Subtype PubMed ID
nsv833590 CNV Gain 17160897
nsv909382 CNV Loss 21882294
esv2664848 CNV Deletion 23128226
dgv1011e1 CNV Complex 17122850
nsv909383 CNV Gain 21882294
nsv909384 CNV Gain 21882294

Relevant External Links for MPPE1 Gene

HapMap Linkage Disequilibrium report
MPPE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPPE1 Gene

Disorders for MPPE1 Gene

Relevant External Links for MPPE1

Genetic Association Database (GAD)
MPPE1
Human Genome Epidemiology (HuGE) Navigator
MPPE1
genes like me logo Genes that share disorders with MPPE1: view

No data available for UniProtKB/Swiss-Prot for MPPE1 Gene

Publications for MPPE1 Gene

  1. Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder. (PMID: 19859903) Lohoff F.W. … Bloch P.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 23 48
  2. cDNA cloning, genomic organization and expression of the novel human metallophosphoesterase gene MPPE1 on chromosome 18p11.2. (PMID: 11978971) Vuoristo J.T. … Ala-Kokko L. (Cytogenet. Cell Genet. 2001) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PMID: 19328558) Yosifova A. … Nakamura Y. (J Affect Disord 2009) 3 48
  5. GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi. (PMID: 19837036) Fujita M. … Kinoshita T. (Cell 2009) 3 4

Products for MPPE1 Gene

Sources for MPPE1 Gene

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