Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MPPE1 Gene

protein-coding   GIFtS: 51
GCID: GC18M013241

Metallophosphoesterase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Metallophosphoesterase 11 2
Post-GPI Attachment To Proteins Factor 52 3
PGAP52 3
Metallo Phosphoesterase2
EC 3.1.-.-3

External Ids:    HGNC: 159881   Entrez Gene: 652582   Ensembl: ENSG000001548897   OMIM: 6119005   UniProtKB: Q53F393   

Export aliases for MPPE1 gene to outside databases

Previous GC identifers: GC18P012145 GC18M011940 GC18M011873 GC18M011883 GC18M012550 GC18M012841


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for MPPE1 Gene:
MPPE1 (metallophosphoesterase 1) is a protein-coding gene. Diseases associated with MPPE1 include bipolar disorder, and malaria. GO annotations related to this gene include manganese ion binding and GPI anchor binding.

UniProtKB/Swiss-Prot: MPPE1_HUMAN, Q53F39
Function: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to
the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain
ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient
transport of GPI-anchor proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the MPPE1 gene promoter:
         TBP   HNF-1   TFIID   Bach2   HOXA5   c-Myb   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMPPE1 promoter sequence
   Search Chromatin IP Primers for MPPE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MPPE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.21   Ensembl cytogenetic band:  18p11.21   HGNC cytogenetic band: 18p11.21

MPPE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPPE1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M013241:  view genomic region     (about GC identifiers)

Start:
11,882,621 bp from pter      End:
11,909,222 bp from pter
Size:
26,602 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MPPE1_HUMAN, Q53F39 (See protein sequence)
Recommended Name: Metallophosphoesterase 1  
Size: 396 amino acids; 45141 Da
Cofactor: Binds 2 manganese ions per subunit (Probable)
Subunit: Interacts with GPI-anchor proteins. Interacts with TMED10
Sequence caution: Sequence=BAB13863.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14378.1; Type=Frameshift; Positions=201;
Secondary accessions: B0YJ39 B0YJ40 B0YJ41 B5ME53 B7WNJ3 D3DUI5 D3DUI7 Q6GMP1 Q8TAD6 Q8TE26
Q8WZ32 Q9BU58 Q9H958 Q9HAI4
Alternative splicing: 5 isoforms:  Q53F39-1   Q53F39-2   Q53F39-3   Q53F39-4   Q53F39-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MPPE1: NX_Q53F39

Explore proteomics data for MPPE1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys289
  • Modification sites at PhosphoSitePlus

  • See MPPE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229833.1  NP_075563.3  

    ENSEMBL proteins: 
     ENSP00000465894   ENSP00000327257   ENSP00000433950   ENSP00000312935   ENSP00000311200  
     ENSP00000339423   ENSP00000464842   ENSP00000466291   ENSP00000468606   ENSP00000466303  
     ENSP00000467993   ENSP00000467698   ENSP00000465318   ENSP00000468639   ENSP00000468065  
     ENSP00000467703   ENSP00000468269   ENSP00000467599   ENSP00000382860  

    MPPE1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MPPE1
    GenScript Custom Purified and Recombinant Proteins Services for MPPE1
    Novus Biologicals MPPE1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MPPE1

    MPPE1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MPPE1
    Novus Biologicals MPPE1 Antibodies
    Abcam antibodies for MPPE1
    Cloud-Clone Corp. Antibodies for MPPE1
    Search ThermoFisher Antibodies for MPPE1
    LSBio Antibodies in human, mouse, rat for MPPE1

    MPPE1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MPPE1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MPPE1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MPPE1
    Cloud-Clone Corp. CLIAs for MPPE1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR024654 Calcineurin-like_PEstase_dom

    Graphical View of Domain Structure for InterPro Entry Q53F39

    ProtoNet protein and cluster: Q53F39

    UniProtKB/Swiss-Prot: MPPE1_HUMAN, Q53F39
    Domain: The di-lysine motif (KxKxx) acts as an endoplasmic reticulum retrieval signal
    Similarity: Belongs to the metallophosphoesterase superfamily. MPPE1 family


    MPPE1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPPE1_HUMAN, Q53F39
    Function: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to
    the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain
    ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient
    transport of GPI-anchor proteins

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008081phosphoric diester hydrolase activity ISS--
    GO:0016787hydrolase activity ----
    GO:0030145manganese ion binding ISS--
    GO:0034235GPI anchor binding ISS--
         
    MPPE1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Mppe1 (no phenotypes)

    MPPE1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MPPE1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MPPE1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MPPE1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MPPE1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MPPE1:
    hsa-mir-101-3p (MIRT027280)

    Block miRNA regulation of human, mouse, rat MPPE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MPPE1 (see all 10):
    hsa-miR-146a hsa-let-7a-2* hsa-miR-570 hsa-miR-3161 hsa-let-7g* hsa-miR-3674 hsa-miR-3662 hsa-miR-589
    SwitchGear 3'UTR luciferase reporter plasmidMPPE1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MPPE1
    Predesigned siRNA for gene silencing in human, mouse, rat MPPE1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MPPE1

    Clone
    Products:
         
    OriGene clones in human, mouse for MPPE1 (see all 7)
    OriGene ORF clones in mouse, rat for MPPE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MPPE1 (NM_023075)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPPE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPPE1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MPPE1
    Browse ESI BIO Cell Lines and PureStem Progenitors for MPPE1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPPE1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MPPE1_HUMAN, Q53F39: Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein.
    Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Note=Also localizes to endoplasmic
    reticulum exit site
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    golgi apparatus3
    plasma membrane3
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment ISS--
    GO:0005794Golgi apparatus IEA--
    GO:0005801cis-Golgi network ISS--
    GO:0016021integral component of membrane IEA--
    GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane IEA--

    MPPE1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MPPE1
    Interactions:

        Search GeneGlobe Interaction Network for MPPE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MPPE1 (Q53F393 ENSP000003112004) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRNKL1Q9BZJ03I2D: score=4 
    ERHP840903I2D: score=4 
    INTS10Q9NVR23I2D: score=4 
    KIFAP3Q928453I2D: score=4 
    LIPAP385713I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006506GPI anchor biosynthetic process ISS--
    GO:0006888ER to Golgi vesicle-mediated transport ISS--

    MPPE1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MPPE1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MPPE1 gene (3 alternative transcripts): 
    NM_138608.2  NM_001242904.1  NM_023075.5  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000588072 ENST00000317235(uc002kqg.3 uc002kqh.3 uc002kqi.3 uc002kqf.3 uc002kqn.3 uc002kqm.3)
    ENST00000496196 ENST00000317251 ENST00000309976(uc010dla.2) ENST00000344987
    ENST00000592755 ENST00000592447 ENST00000592306 ENST00000592894 ENST00000587724
    ENST00000592977 ENST00000589731 ENST00000592331 ENST00000588186 ENST00000588191
    ENST00000589267 ENST00000586364
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MPPE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MPPE1 (see all 10):
    hsa-miR-146a hsa-let-7a-2* hsa-miR-570 hsa-miR-3161 hsa-let-7g* hsa-miR-3674 hsa-miR-3662 hsa-miR-589
    SwitchGear 3'UTR luciferase reporter plasmidMPPE1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MPPE1
    Predesigned siRNA for gene silencing in human, mouse, rat MPPE1
    Clone
    Products:
         
    OriGene clones in human, mouse for MPPE1 (see all 7)
    OriGene ORF clones in mouse, rat for MPPE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MPPE1 (NM_023075)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPPE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPPE1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MPPE1
    OriGene qSTAR qPCR primer pairs in human, mouse for MPPE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MPPE1
      QuantiTect SYBR Green Assays in human, mouse, rat MPPE1
      QuantiFast Probe-based Assays in human, mouse, rat MPPE1

    Selected AceView cDNA sequences (see all 184):

    CR594517 AI989343 BM807059 BU688654 AX775853 BP431483 BC002877 BU732430 
    BM966916 BX388179 CR611565 AX775855 CR591893 CA489335 AW969558 BU951741 
    BF507761 BM709282 CR595199 AI651909 BX388178 CR594849 AI348585 AX775857 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MPPE1 (see all 25)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ·
    SP1:                                            -                 -     -     -     -     -     -     -     -     -     -     -     -                           
    SP2:                                            -                 -     -     -     -     -     -     -     -     -     -                                       
    SP3:                                            -                 -     -     -     -     -     -     -     -     -     -                                       
    SP4:                                            -     -     -     -     -     -     -     -     -     -     -     -     -                                       
    SP5:                                            -     -     -     -     -     -     -     -     -     -     -     -     -                                       

    ExUns: 13e ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c · 23d
    SP1:                                                  -                 -           -                                 
    SP2:        -                                         -                 -           -                                 
    SP3:        -                                         -                 -           -     -                           
    SP4:        -                                         -     -     -     -           -     -                           
    SP5:        -                                         -                                                               


    ECgene alternative splicing isoforms for MPPE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MPPE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACGACAGTC
    MPPE1 Expression
    About this image


    MPPE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    MPPE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MPPE1 Protein Expression

    UniProtKB/Swiss-Prot: MPPE1_HUMAN, Q53F39
    Tissue specificity: Expressed in brain

        Custom PCR Arrays for MPPE1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MPPE1
    OriGene qSTAR qPCR primer pairs in human, mouse for MPPE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MPPE1
    QuantiTect SYBR Green Assays in human, mouse, rat MPPE1
    QuantiFast Probe-based Assays in human, mouse, rat MPPE1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPPE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MPPE1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mppe11 , 5 metallophosphoesterase 11, 5 78.41(n)1
    75.39(a)1
      18 (39.90 cM)5
    2256511  NM_172630.21  NP_766218.11 
     672255305 
    chicken
    (Gallus gallus)
    Aves MPPE11 metallophosphoesterase 1 70.43(n)
    66.93(a)
      421031  NM_001039283.2  NP_001034372.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mppe11 metallophosphoesterase 1 65.37(n)
    62.78(a)
      100492787  XM_004915249.1  XP_004915306.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mppe11 metallophosphoesterase 1 59.49(n)
    56.4(a)
      550396  NM_001017701.1  NP_001017701.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG84551 , 3 CG84551 43(a)3
    51.28(n)1
    43.79(a)1
      28F13
    341161  NM_001273302.11  NP_001260231.11 
    worm
    (Caenorhabditis elegans)
    Secernentea B0511.131 , 3 B0511.131 33(a)3
    46.84(n)1
    38.92(a)1
      I(10641572-10644059)3
    1729561  NM_001264514.11  NP_001251443.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC1(YDR182W)4 Putative lipid phosphatase of the endoplasmic reticulum; more   --   4(827582-829057) 851763  NP_010468.1 


    ENSEMBL Gene Tree for MPPE1 (if available)
    TreeFam Gene Tree for MPPE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MPPE1 gene

    MPPE1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for MPPE1
    PGOHUM00000247880 PGOHUM00000246265 PGOHUM00000245532


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MPPE1 (see all 652)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs169768191,2
    C,F,H--11886194(+) TTTTCA/GGTTCC 5 -- int19Minor allele frequency- G:0.09NA NS EA WA 798
    rs12499011,2
    H--11886246(+) AATACA/CAAGAA 5 -- int15Minor allele frequency- C:0.00MN NS EA 600
    rs343145121,2
    C--11886314(+) AAAAA-/AGCGAT 5 -- int11Minor allele frequency- A:0.50NA 2
    rs116602681,2
    H--11886342(+) TACTGT/AGAAAG 5 -- int14Minor allele frequency- A:0.00NS EA 414
    rs767600611,2
    C--11886387(+) TAAGTC/GATGAA 5 -- int10--------
    rs1832999061,2
    C--11886464(+) CACTGC/TGACAT 5 -- int10--------
    rs1458705731,2
    F--11886514(+) CCTCCC/TGTGAA 6 Q R int1 nc-transcript-variantmis11Minor allele frequency- T:0.00NA 4544
    rs1399062471,2
    C--11886515(+) CTCCCG/ATGAAA 6 /R /W int1 nc-transcript-variantmis11Minor allele frequency- A:0.00NA 4544
    rs2005789761,2
    --11886562(+) CCTCTA/GCAGGA 6 A V int1 nc-transcript-variantmis10--------
    rs6625151,2,,4
    C,F,A,H--11886563(+) CTCTGC/GAGGAG 6 P A int1 nc-transcript-variantmis1 ese330Minor allele frequency- G:0.44MN EA NA NS WA CSA EU 7602

    HapMap Linkage Disequilibrium report for MPPE1 (11882621 - 11909222 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MPPE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664848CNV Deletion23128226
    nsv909382CNV Loss21882294
    nsv909384CNV Gain21882294
    nsv833590CNV Gain17160897
    nsv909383CNV Gain21882294
    dgv1011e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MPPE1
    DNA2.0 Custom Variant and Variant Library Synthesis for MPPE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611900    OMIM disorders: --

    2 diseases for MPPE1:    
    About MalaCards
    bipolar disorder    malaria


    MPPE1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MPPE1
    Human Genome Epidemiology (HuGE) Navigator: MPPE1 (2 documents)

    Export disorders for MPPE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MPPE1 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with MPPE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, genomic organization and expression of the novel human metallophosphoesterase gene MPPE1 on chromosome 18p11.2. (PubMed id 11978971)1, 2, 3 Vuoristo J.T. and Ala-Kokko L. (Cytogenet. Cell Genet. 2001)
    2. Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder. (PubMed id 19859903)1, 4, 9 Lohoff F.W....Bloch P.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi. (PubMed id 19837036)1, 2 Fujita M.... Kinoshita T. (Cell 2009)
    4. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PubMed id 19328558)1, 4 Yosifova A....Nakamura Y. (J Affect Disord 2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (Nature 2005)
    9. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 65258 HGNC: 15988 AceView: MPPE1 Ensembl:ENSG00000154889 euGenes: HUgn65258
    ECgene: MPPE1 H-InvDB: MPPE1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MPPE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MPPE1 gene:
    Search GeneIP for patents involving MPPE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MPPE1  
     OriGene qPCR primer pairs and template standards for MPPE1   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MPPE1  
     OriGene qSTAR qPCR primer pairs in human, mouse for MPPE1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MPPE1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MPPE1   OriGene Custom Protein Services for MPPE1  

     
     
     Block miRNA regulation of human, mouse, rat MPPE1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MPPE1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MPPE1 Predesigned siRNA for gene silencing in human, mouse, rat MPPE1
     QuantiFast Probe-based Assays in human, mouse, rat MPPE1 QuantiTect SYBR Green Assays in human, mouse, rat MPPE1
     Custom PCR Arrays for MPPE1 Search Chromatin IP Primers for MPPE1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MPPE1  Search GeneGlobe Interaction Network for MPPE1
     Regulatory tfbs in MPPE1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MPPE1 GenScript cDNA clones with any tag delivered in your preferred vector for MPPE1
     GenScript Custom Assay Services for MPPE1 GenScript Custom overexpressing Cell Line Services for MPPE1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MPPE1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MPPE1 antibodies
     MPPE1 proteins
     Antibodies for MPPE1
     See all of Abcam's Antibodies, Kits and Proteins for MPPE1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MPPE1
     Antibodies for MPPE1
     ELISAs for MPPE1
     CLIAs for MPPE1



     Browse ESI BIO Cell Lines and PureStem Progenitors for MPPE1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPPE1
     SwitchGear 3'UTR luciferase reporter plasmids for MPPE1
     SwitchGear Promoter luciferase reporter plasmids for MPPE1
     Search ThermoFisher Antibodies for MPPE1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPPE1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MPPE1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MPPE1
     LSBio Antibodies in human, mouse, rat for MPPE1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MPPE1 gene at Home site.
    Version: 3.12.158 12 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4