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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MPP7 Gene

protein-coding   GIFtS: 51
GCID: GC10M028382

membrane protein, palmitoylated 7 (MAGUK p55 subfamily member...
 Explore 6 diseases affiliated with
MPP7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MPP7    

Aliases
for MPP7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Membrane Protein, Palmitoylated 7 (MAGUK P55 Subfamily Member 7)1 2
FLJ327981
MAGUK P55 Subfamily Member 72

External Ids:    HGNC: 265421   Entrez Gene: 1430982   Ensembl: ENSG000001500547   OMIM: 6109735   UniProtKB: Q5T2T13   

Export aliases for MPP7 gene to outside databases

Previous GC identifers: GC10M028346 GC10M028057


Summaries
for MPP7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MPP7:
Membrane-associated guanylate kinases (MAGUKs) are important adaptor proteins involved in the assembly of protein
complexes at sites of cell-cell contact. They are found in synapses, adherens junctions, and tight junctions. All
MAGUKs contain at least 1 PDZ domain, an SH3 domain, and a GUK domain, and many contain 1 or 2 L27 domains, which are
involved in multimerization of MAGUKs. MPP7 belongs to the p55 stardust subfamily of MAGUKs, which is named for a
Drosophila gene required for establishment of cell polarity in the developing fly embryo (Bohl et al., 2007 (PubMed
17237226)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: MPP7_HUMAN, Q5T2T1
Function: Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its
interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact




Genomic Views
for MPP7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MPP7 gene promoter:
         HOXA3   FOXO3   YY1   FOXO3b   RORalpha2   HNF-1A   E47   RORalpha1   HNF-1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MPP7 promoter sequence
   Search SABiosciences Chromatin IP Primers for MPP7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.1   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p12.1

MPP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPP7 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M028382:  view genomic region     (about GC identifiers)

Start:
 28,339,922 bp from pter      End:
 28,591,995 bp from pter
Size:
 252,074 bases      Orientation:
 minus strand

Proteins
for MPP7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MPP7_HUMAN, Q5T2T1 (See protein sequence)
Recommended Name: MAGUK p55 subfamily member 7  
Size: 576 amino acids; 65524 Da
Subunit: Heterodimer; able to heterodimerize via its C-terminal L27 domain with LIN7A, LIN7B and LIN7C. Forms a
tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C). Interacts with DLG1 via its N-terminal L27
domain. Interacts with MPP5 and INADL/PATJ
Subcellular location: Membrane; Peripheral membrane protein. Cell junction, tight junction. Cell junction, adherens
junction
Sequence caution: Sequence=CAI12709.1; Type=Erroneous gene model prediction; Sequence=CAI13640.1; Type=Erroneous gene
model prediction; Sequence=CAI17344.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for MPP7:
3LRA (3D)        3O46 (3D)    
Secondary accessions: B2RCC9 B5MDZ3 D3DRW3 Q5T2T0 Q8IY28

Explore the universe of human proteins at neXtProt for MPP7: NX_Q5T2T1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5T2T1

    • MPP7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_775767.2  
    ENSEMBL proteins: 
     ENSP00000364884   ENSP00000364871   ENSP00000398319   ENSP00000337907   ENSP00000438693  
     ENSP00000405397  

    Human Recombinant Protein Products: 
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    Novus Biologicals MPP7 Protein
    Novus Biologicals MPP7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MPP7

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005912adherens junction IDA17237226
    GO:0005923tight junction IDA17332497
    GO:0097025MPP7-DLG1-LIN7 complex IDA17237226


    MPP7 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MPP7

    Protein Domains /
    Families
    for MPP7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MPP7 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR008144 Guanylate_kin
     IPR008145 Guanylate_kin/L-typ_Ca_channel
     IPR014775 L27_C
     IPR001452 SH3_domain
     IPR011511 SH3_2

    Graphical View of Domain Structure for InterPro Entry Q5T2T1

    ProtoNet protein and cluster: Q5T2T1

    3 Blocks protein families:
    IPB004172 L27 domain
    IPB008144 Guanylate kinase
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: MPP7_HUMAN, Q5T2T1
    Similarity: Belongs to the MAGUK family
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 2 L27 domains
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 SH3 domain


    Function
    for MPP7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MPP7_HUMAN, Q5T2T1
    Function: Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its
    interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact
    Induction: Down-regulated in patients suffering of passive Heymann nephritis (at protein level)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MPP7
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPP7
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate MPP7 (see all 23):
    hsa-miR-3673 hsa-miR-181c hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-340 hsa-miR-3658 hsa-miR-532-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MPP7 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPP7 (see all 4)
    OriGene shRNA RFP: MPP7
    OriGene siRNA: MPP7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPP7

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MPP7

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPP7 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MPP7 (NM_173496)
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    Cell Line
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    Search LifeMap BioReagents cell lines for MPP7

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17237226
    GO:0019904protein domain specific binding IPI17332497
    GO:0032947protein complex scaffold IDA17237226
    GO:0035591signaling adaptor activity TAS--
    GO:0046982protein heterodimerization activity IDA17237226


    MPP7 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for MPP7:
     Decreased viability with pacli  Increased number of cells in m  Metaphase cells 

    Animal Models:
         1 MGI phenotypic allele for Mpp7 (no phenotypes)

    MPP7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MPP7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MPP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for MPP7 (Q5T2T13 ENSP000003379074) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMOTQ4VCS53, ENSP000003610274I2D: score=3 STRING: ENSP00000361027
    ASF1BENSP000002633824STRING: ENSP00000263382
    DLG1ENSP000003457314STRING: ENSP00000345731
    CHAF1AENSP000003012804STRING: ENSP00000301280
    ASF1AENSP000002295954STRING: ENSP00000229595
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009967positive regulation of signal transduction TAS--
    GO:0030010establishment of cell polarity TAS17332497
    GO:0031334positive regulation of protein complex assembly TAS14719143
    GO:0070830tight junction assembly IDA17332497
    GO:0071896protein localization to adherens junction IMP17237226


    MPP7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MPP7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MPP7
    Search CenterWatch for drugs/clinical trials and news about MPP7 

    Transcripts
    for MPP7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MPP7 gene: 
    NM_173496.3  

    Unigene Cluster for MPP7:

    Membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
    Hs.499159  [show with all ESTs]
    Unigene Representative Sequence: NM_173496
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375732(uc009xkz.1 uc001iub.1 uc009xla.2) ENST00000496637
    ENST00000375719 ENST00000441595 ENST00000481244 ENST00000474731 ENST00000474682
    ENST00000337532(uc001iua.1) ENST00000540098 ENST00000445954(uc010qdv.1)


    miRNA
    Products:             		 OriGene 3'-UTR Clone: MPP7
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPP7
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate MPP7 (see all 23):
    hsa-miR-3673 hsa-miR-181c hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-340 hsa-miR-3658 hsa-miR-532-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MPP7 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPP7 (see all 4)
    OriGene shRNA RFP: MPP7
    OriGene siRNA: MPP7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPP7
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPP7
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MPP7 (NM_173496)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPP7 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MPP7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPP7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPP7

    Additional cDNA sequence: 

    AK057360.2 AK130972.1 AK301592.1 AK315046.1 AL832380.1 BC038105.2 

    9 DOTS entries:

    DT.95368746  DT.40211497  DT.100787402  DT.75100424  DT.101956051  DT.95185430  DT.100705424  DT.95368748 
    DT.99970810 

    24/66 AceView cDNA sequences (see all 66):

    CR623672 AI653238 AA322046 AA878649 BU674299 AI034481 BQ774044 AA247946 
    BE887502 BU607636 AK130972 CB145141 BQ435135 AW006286 T71146 BI828144 
    BX364722 BX506506 AI244661 BQ323952 BU509326 BC038105 BU902689 BM457725 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MPP7 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^
    SP1:                    -     -                       -     -                                                                 -                       -         
    SP2:              -     -     -     -                 -     -                                                                 -                       -         
    SP3:                                                  -     -                                                                 -                                 
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24a · 24b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for MPP7

    Expression
    for MPP7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MPP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCATCTTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MPP7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)

    See MPP7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MPP7

    SOURCE GeneReport for Unigene cluster: Hs.499159
        SABiosciences Custom PCR Arrays for MPP7
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPP7
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP7

    Orthologs
    for MPP7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for MPP7 gene from 9/31 species (see all 31)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mpp71 , 5 membrane protein, palmitoylated 7 (MAGUK p55 subfamily more1, 5 87.91(n)1
    92.53(a)1    		   18 (4.53 cM)5
    757391  NM_001081287.21  NP_001074756.21 
     73479625 
    chicken
    (Gallus gallus)    		 Aves MPP71 membrane protein, palmitoylated 7 (MAGUK p55 subfamily more 84.55(n)
    91.84(a)    		   420481  XM_418583.2  XP_418583.2 
    lizard
    (Anolis carolinensis)    		 Reptilia MPP76
    --
    (see all 3)    		 --
    		 82(a)
    37(a)
    (see all 3)    		 1 ↔ 1
    possible ortholog
    (see all 3)    		 6(13982787-14026031)
    GL344565.1(6101-23422)
    zebrafish
    (Danio rerio)    		 Actinopterygii hmp2 humpback 76.31(n)   30166  AF124435.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta metro1 menage a trois 49.67(n)
    41.68(a)    		   36176  NM_136798.2  NP_610642.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea magu-11 Protein MAGU-1 47.26(n)
    39.11(a)    		   190302  NM_064800.1  NP_497201.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons GK-16
    AT3G062006
    (see all 3)    		 guanylate kinase
    (see all 3)    		 18(a)
    17(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 2(17474619-17477223)
    3(1877594-1879348)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 guanylate kinase, putative, expressed
    		 18(a)
    17(a)
    		 possible ortholog
    possible ortholog
    		 3(11594171-11597778)
    12(20000190-20004313)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria gmk6
    		 guanylate kinase
    		 27(a)
    		 possible ortholog
    		 Chromosome(3819451-3820074)


    ENSEMBL Gene Tree for MPP7 (if available)
    TreeFam Gene Tree for MPP7 (if available) 

    Paralogs
    for MPP7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MPP7 gene
    MPP62  DLG32  MPP52  DLG22  MPP22  MPP42  DLG42  DLG12  
    CASK2  MPP12  MPP32  
    11 SIMAP similar genes for MPP7 using alignment to 2 protein entries:     MPP7_HUMAN (see all proteins):
    MPP3    DKFZp666F1010    MPP5    MPP4    MPP6    DKFZp666D023
    GUK1    MPP2    MPP1    DLG2    CASK

    MPP7 for paralogs           About GeneDecksing



    Genomic Variants
    for MPP7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4124 NCBI SNPs in MPP7 are shown (see all 4124)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs781567361,2
    		C,--28339470(+) GAGGT-/CAWGTGT 1 -- ds50010--------
    rs752899341,2
    		C,--28339471(+) AGGTT-/CAGTGTT 1 -- ds50010--------
    rs37808581,2
    		C,F,--28339773(-) CCCCAC/TCTCCT 1 -- ds50011Minor allele frequency- T:0.12EA 120
    rs1504117371,2
    		--28339822(+) TCTTCC/TTTCCC 1 -- ds50010--------
    rs1844595111,2
    		--28339868(+) TATGGA/GTAAGA 1 -- ds50010--------
    rs37808571,2
    		C,F,H,--28339909(-) TTCATC/GGAGGC 1 -- ds50019Minor allele frequency- G:0.14EA NA NS 1924
    rs1889630431,2
    		--28339911(+) CTCGAC/TGAAAG 1 -- ds50010--------
    rs37808561,2
    		C,F,A,--28340000(-) AAATTA/CTATTT 1 -- ut315Minor allele frequency- C:0.21WA CSA EA 244
    rs1451874461,2
    		--28340234(+) AAGGTC/TATGTT 1 -- ut310--------
    rs1813327131,2
    		--28340239(+) TATGTC/TTGTCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MPP7 (28339922 - 28589922 bp, first 250kb of MPP7)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 22 variations for MPP7
         15 CNVs: 48518 70945 38194 48517 1875 85163 1220 10322 65628 85161 65627 48520 48519 34870 10321
         7 Indels: 85159 85160 85162 75159 85158 58437 75158
    Human Gene Mutation Database (HGMD): MPP7

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPP7
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    Disorders / Diseases
    for MPP7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MPP7 for disorders           About GeneDecksing

    OMIM gene information: 610973    OMIM disorders: --

    6 diseases for MPP7:    About MalaCards
    nephritis    alzheimer's disease    pneumonia    tuberculosis
    malaria    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: MPP7 (2 documents)

    Export disorders for MPP7 gene to outside databases

    Publications
    for MPP7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MPP7 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with MPP7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human MPP7 gene and mouse Mpp7 gene in silico. (PubMed id 14719143)1, 2, 3, 9 Katoh M. and Katoh M. (2004)
    2. The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation. (PubMed id 17332497)1, 2 Stucke V.M....Hall A. (2007)
    3. The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions. (PubMed id 17237226)1, 2 Bohl J.... Vande Pol S.B. (2007)
    4. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. (PubMed id 16678097)1, 2 Wells C.D.... Pawson T. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Post-genome wide association studies and functional an alyses identify association of MPP7 gene variants with site-specific bone minera l density. (PubMed id 22171069)1 Xiao S.M....Sham P.C. (2012)
    7. Genome-wide association study of Alzheimer's disease w ith psychotic symptoms. (PubMed id 22005930)1 Hollingworth P....Williams J. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for MPP7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing MPP7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 143098 HGNC: 26542 AceView: MPP7 Ensembl:ENSG00000150054 euGenes: HUgn143098
    ECgene: MPP7 H-InvDB: MPP7

    Other Databases showing MPP7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MPP7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MPP7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MPP7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MPP7 gene:
    Search GeneIP for patents involving MPP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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