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Aliases for MPP7 Gene

Aliases for MPP7 Gene

  • Membrane Protein, Palmitoylated 7 (MAGUK P55 Subfamily Member 7) 2 3

External Ids for MPP7 Gene

Previous GeneCards Identifiers for MPP7 Gene

  • GC10M028346
  • GC10M028382

Summaries for MPP7 Gene

Entrez Gene Summary for MPP7 Gene

  • Membrane-associated guanylate kinases (MAGUKs) are important adaptor proteins involved in the assembly of protein complexes at sites of cell-cell contact. They are found in synapses, adherens junctions, and tight junctions. All MAGUKs contain at least 1 PDZ domain, an SH3 domain, and a GUK domain, and many contain 1 or 2 L27 domains, which are involved in multimerization of MAGUKs. MPP7 belongs to the p55 stardust subfamily of MAGUKs, which is named for a Drosophila gene required for establishment of cell polarity in the developing fly embryo (Bohl et al., 2007 [PubMed 17237226]).[supplied by OMIM, Mar 2008]

GeneCards Summary for MPP7 Gene

MPP7 (Membrane Protein, Palmitoylated 7 (MAGUK P55 Subfamily Member 7)) is a Protein Coding gene. GO annotations related to this gene include protein heterodimerization activity and protein complex scaffold. An important paralog of this gene is MPP6.

UniProtKB/Swiss-Prot for MPP7 Gene

  • Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPP7 Gene

Genomics for MPP7 Gene

Regulatory Elements for MPP7 Gene

Genomic Location for MPP7 Gene

Start:
28,050,993 bp from pter
End:
28,334,486 bp from pter
Size:
283,494 bases
Orientation:
Minus strand

Genomic View for MPP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPP7 Gene

Proteins for MPP7 Gene

  • Protein details for MPP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T2T1-MPP7_HUMAN
    Recommended name:
    MAGUK p55 subfamily member 7
    Protein Accession:
    Q5T2T1
    Secondary Accessions:
    • B2RCC9
    • B4DWL9
    • B5MDZ3
    • D3DRW3
    • Q5T2T0
    • Q8IY28

    Protein attributes for MPP7 Gene

    Size:
    576 amino acids
    Molecular mass:
    65524 Da
    Quaternary structure:
    • Heterodimer; able to heterodimerize via its C-terminal L27 domain with LIN7A, LIN7B and LIN7C. Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C). Interacts with DLG1 via its N-terminal L27 domain. Interacts with MPP5 and INADL/PATJ.
    SequenceCaution:
    • Sequence=CAI12709.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13640.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI17344.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MPP7 Gene

    Alternative splice isoforms for MPP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPP7 Gene

Proteomics data for MPP7 Gene at MOPED

Post-translational modifications for MPP7 Gene

  • Ubiquitination at Lys387 and Lys433
  • Modification sites at PhosphoSitePlus

Other Protein References for MPP7 Gene

No data available for DME Specific Peptides for MPP7 Gene

Domains for MPP7 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T2T1

UniProtKB/Swiss-Prot:

MPP7_HUMAN :
  • Q5T2T1
Domain:
  • Contains 1 guanylate kinase-like domain.
  • Contains 2 L27 domains.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the MAGUK family.
genes like me logo Genes that share domains with MPP7: view

No data available for Gene Families for MPP7 Gene

Function for MPP7 Gene

Molecular function for MPP7 Gene

UniProtKB/Swiss-Prot Function: Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact.
UniProtKB/Swiss-Prot Induction: Down-regulated in patients suffering of passive Heymann nephritis (at protein level).

Gene Ontology (GO) - Molecular Function for MPP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17237226
GO:0019904 protein domain specific binding IPI 17332497
GO:0032947 protein complex scaffold IDA 17237226
GO:0035591 signaling adaptor activity TAS 20702775
GO:0046982 protein heterodimerization activity IDA 17237226
genes like me logo Genes that share ontologies with MPP7: view
genes like me logo Genes that share phenotypes with MPP7: view

Animal Model Products

CRISPR Products

miRNA for MPP7 Gene

miRTarBase miRNAs that target MPP7

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MPP7 Gene

Localization for MPP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPP7 Gene

Membrane; Peripheral membrane protein. Cell junction, tight junction. Cell junction, adherens junction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MPP7 Gene COMPARTMENTS Subcellular localization image for MPP7 gene
Compartment Confidence
plasma membrane 4
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MPP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005912 adherens junction IDA 17237226
GO:0005923 bicellular tight junction IDA 17332497
GO:0030054 cell junction IDA --
GO:0097025 MPP7-DLG1-LIN7 complex IDA 17237226
genes like me logo Genes that share ontologies with MPP7: view

Pathways for MPP7 Gene

SuperPathways for MPP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MPP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009967 positive regulation of signal transduction TAS 20702775
GO:0030010 establishment of cell polarity TAS 17332497
GO:0031334 positive regulation of protein complex assembly TAS 14719143
GO:0070830 bicellular tight junction assembly IDA 17332497
GO:0071896 protein localization to adherens junction IMP 17237226
genes like me logo Genes that share ontologies with MPP7: view

No data available for Pathways by source for MPP7 Gene

Transcripts for MPP7 Gene

Unigene Clusters for MPP7 Gene

Membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPP7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MPP7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPP7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:

ExUns: 23 ^ 24a · 24b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for MPP7 Gene

GeneLoc Exon Structure for
MPP7
ECgene alternative splicing isoforms for
MPP7

Expression for MPP7 Gene

mRNA expression in normal human tissues for MPP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPP7 Gene

SOURCE GeneReport for Unigene cluster for MPP7 Gene Hs.499159

genes like me logo Genes that share expressions with MPP7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MPP7 Gene

Orthologs for MPP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for MPP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MPP7 35
  • 99.71 (n)
  • 99.65 (a)
MPP7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MPP7 35
  • 91.2 (n)
  • 96.18 (a)
MPP7 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MPP7 35
  • 92.65 (n)
  • 96.87 (a)
MPP7 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mpp7 35
  • 87.91 (n)
  • 92.53 (a)
Mpp7 16
Mpp7 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MPP7 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MPP7 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mpp7 35
  • 87.91 (n)
  • 95.14 (a)
chicken
(Gallus gallus)
Aves MPP7 35
  • 84.49 (n)
  • 91.67 (a)
MPP7 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MPP7 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mpp7 35
  • 79.22 (n)
  • 82.99 (a)
zebrafish
(Danio rerio)
Actinopterygii hmp 35
mpp7 35
  • 69.56 (n)
  • 75.35 (a)
mpp7 36
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010230 35
  • 52.4 (n)
  • 45.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta metro 35
  • 50.45 (n)
  • 42.52 (a)
metro 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea magu-1 35
  • 47.7 (n)
  • 39.11 (a)
magu-1 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for MPP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPP7 Gene

ENSEMBL:
Gene Tree for MPP7 (if available)
TreeFam:
Gene Tree for MPP7 (if available)

Paralogs for MPP7 Gene

Paralogs for MPP7 Gene

Selected SIMAP similar genes for MPP7 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MPP7: view

Variants for MPP7 Gene

Sequence variations from dbSNP and Humsavar for MPP7 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs786691 -- 28,276,484(-) TGTAT(A/G)TAGAA intron-variant
rs786692 -- 28,242,361(+) AAAAA(A/T)AAATC intron-variant
rs927675 -- 28,094,004(-) TGCTT(G/T)CTTTG intron-variant
rs927676 -- 28,092,042(-) ACCCA(A/G)TGGTA intron-variant
rs1022878 -- 28,139,997(-) GTTTC(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPP7 Gene

Variant ID Type Subtype PubMed ID
esv2734606 CNV Deletion 23290073
nsv831815 CNV Loss 17160897
nsv831816 CNV Gain 17160897
nsv894988 CNV Loss 21882294
nsv525448 CNV Loss 19592680
nsv820072 CNV Loss 19587683
nsv831817 CNV Loss 17160897
nsv894989 CNV Loss 21882294
esv2734772 CNV Deletion 23290073
nsv520842 CNV Loss 19592680
nsv521428 CNV Loss 19592680
esv2672420 CNV Deletion 23128226
esv2734783 CNV Deletion 23290073
esv2669951 CNV Deletion 23128226
esv25465 CNV Loss 19812545
nsv521787 CNV Loss 19592680
esv2734794 CNV Deletion 23290073
nsv6188 CNV Loss 18451855
esv2673478 CNV Deletion 23128226
nsv498723 CNV Loss 21111241
esv28176 CNV Loss 19812545
nsv6199 CNV Loss 18451855
dgv5n64 CNV Loss 17921354
nsv466856 CNV Loss 19166990
nsv470929 CNV Loss 18288195
nsv437663 CNV Loss 16327808
esv2421445 CNV Deletion 20811451
esv2661194 CNV Deletion 23128226
nsv515548 CNV Loss 19592680
esv25872 CNV Loss 19812545
nsv514550 CNV Loss 21397061
nsv442175 CNV CNV 18776908
nsv438167 CNV Loss 16468122
nsv818754 CNV Loss 17921354

Relevant External Links for MPP7 Gene

HapMap Linkage Disequilibrium report
MPP7
Human Gene Mutation Database (HGMD)
MPP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPP7 Gene

Disorders for MPP7 Gene

Relevant External Links for MPP7

Genetic Association Database (GAD)
MPP7
Human Genome Epidemiology (HuGE) Navigator
MPP7
genes like me logo Genes that share disorders with MPP7: view

No data available for UniProtKB/Swiss-Prot for MPP7 Gene

Publications for MPP7 Gene

  1. Identification and characterization of human MPP7 gene and mouse Mpp7 gene in silico. (PMID: 14719143) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  4. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. (PMID: 16678097) Wells C.D. … Pawson T. (Cell 2006) 3 4
  5. The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions. (PMID: 17237226) Bohl J. … Vande Pol S.B. (J. Biol. Chem. 2007) 3 4

Products for MPP7 Gene

Sources for MPP7 Gene

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