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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MPP7 Gene

protein-coding   GIFtS: 54
GCID: GC10M028382

Membrane Protein, Palmitoylated 7 (MAGUK P55 Subfamily Member...

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Membrane Protein, Palmitoylated 7 (MAGUK P55 Subfamily Member 7)1 2
MAGUK P55 Subfamily Member 72

External Ids:    HGNC: 265421   Entrez Gene: 1430982   Ensembl: ENSG000001500547   OMIM: 6109735   UniProtKB: Q5T2T13   

Export aliases for MPP7 gene to outside databases

Previous GC identifers: GC10M028346 GC10M028057


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MPP7 Gene:
Membrane-associated guanylate kinases (MAGUKs) are important adaptor proteins involved in the assembly of protein
complexes at sites of cell-cell contact. They are found in synapses, adherens junctions, and tight junctions. All
MAGUKs contain at least 1 PDZ domain, an SH3 domain, and a GUK domain, and many contain 1 or 2 L27 domains, which
are involved in multimerization of MAGUKs. MPP7 belongs to the p55 stardust subfamily of MAGUKs, which is named
for a Drosophila gene required for establishment of cell polarity in the developing fly embryo (Bohl et al., 2007
(PubMed 17237226)).(supplied by OMIM, Mar 2008)

GeneCards Summary for MPP7 Gene: 
MPP7 (membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)) is a protein-coding gene. Diseases associated with MPP7 include nephritis, and pneumonia. GO annotations related to this gene include protein complex scaffold and protein heterodimerization activity. An important paralog of this gene is MPP6.

UniProtKB/Swiss-Prot: MPP7_HUMAN, Q5T2T1
Function: Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its
interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MPP7 gene promoter:
         HOXA3   FOXO3   YY1   FOXO3b   RORalpha2   HNF-1A   E47   RORalpha1   HNF-1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MPP7 promoter sequence
   Search SABiosciences Chromatin IP Primers for MPP7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.1   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p12.1

MPP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPP7 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M028382:  view genomic region     (about GC identifiers)

Start:
28,339,922 bp from pter      End:
28,623,415 bp from pter
Size:
283,494 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MPP7_HUMAN, Q5T2T1 (See protein sequence)
Recommended Name: MAGUK p55 subfamily member 7  
Size: 576 amino acids; 65524 Da
Subunit: Heterodimer; able to heterodimerize via its C-terminal L27 domain with LIN7A, LIN7B and LIN7C. Forms a
tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C). Interacts with DLG1 via its N-terminal L27
domain. Interacts with MPP5 and INADL/PATJ
Subcellular location: Membrane; Peripheral membrane protein. Cell junction, tight junction. Cell junction,
adherens junction
Sequence caution: Sequence=CAI12709.1; Type=Erroneous gene model prediction; Sequence=CAI13640.1; Type=Erroneous
gene model prediction; Sequence=CAI17344.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for MPP7:
3LRA (3D)        3O46 (3D)    
Secondary accessions: B2RCC9 B5MDZ3 D3DRW3 Q5T2T0 Q8IY28

Explore the universe of human proteins at neXtProt for MPP7: NX_Q5T2T1

Explore proteomics data for MPP7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5T2T1

  • MPP7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MPP7 Protein Expression
    REFSEQ proteins: NP_775767.2  
    ENSEMBL proteins: 
     ENSP00000364884   ENSP00000473899   ENSP00000364871   ENSP00000398319   ENSP00000337907  
     ENSP00000438693   ENSP00000405397  

    Human Recombinant Protein Products for MPP7: 
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    Novus Biologicals MPP7 Protein
    Novus Biologicals MPP7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MPP7 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005912adherens junction IDA17237226
    GO:0005923tight junction IDA17332497
    GO:0097025MPP7-DLG1-LIN7 complex IDA17237226

    MPP7 for ontologies           About GeneDecksing



    MPP7 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for MPP7 

    Assay Products for MPP7: 
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    Cloud-Clone Corp. ELISAs for MPP7 
    Cloud-Clone Corp. CLIAs for MPP7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/9 InterPro protein domains (see all 9):
     IPR008144 Guanylate_kin
     IPR008145 Guanylate_kin/L-typ_Ca_channel
     IPR014775 L27_C
     IPR001452 SH3_domain
     IPR011511 SH3_2

    Graphical View of Domain Structure for InterPro Entry Q5T2T1

    ProtoNet protein and cluster: Q5T2T1

    3 Blocks protein domains:
    IPB004172 L27 domain
    IPB008144 Guanylate kinase
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: MPP7_HUMAN, Q5T2T1
    Similarity: Belongs to the MAGUK family
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 2 L27 domains
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 SH3 domain


    MPP7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPP7_HUMAN, Q5T2T1
    Function: Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its
    interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact
    Induction: Down-regulated in patients suffering of passive Heymann nephritis (at protein level)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17237226
    GO:0019904protein domain specific binding IPI17332497
    GO:0032947protein complex scaffold IDA17237226
    GO:0035591signaling adaptor activity TAS--
    GO:0046982protein heterodimerization activity IDA17237226
         
    MPP7 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MPP7:
     Decreased viability with pacli  Increased number of cells in m  Metaphase cells 

         1 MGI phenotypic allele for Mpp7 (no phenotypes)

    MPP7 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MPP7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MPP7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MPP7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MPP7 

    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate MPP7 (see all 23):
    hsa-miR-3673 hsa-miR-181c hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-340 hsa-miR-3658 hsa-miR-532-5p
    SwitchGear 3'UTR luciferase reporter plasmidMPP7 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MPP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for MPP7 (Q5T2T13 ENSP000003379074) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMOTQ4VCS53, ENSP000003610274I2D: score=3 STRING: ENSP00000361027
    ASF1BENSP000002633824STRING: ENSP00000263382
    DLG1ENSP000003457314STRING: ENSP00000345731
    CHAF1AENSP000003012804STRING: ENSP00000301280
    ASF1AENSP000002295954STRING: ENSP00000229595
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009967positive regulation of signal transduction TAS--
    GO:0030010establishment of cell polarity TAS17332497
    GO:0031334positive regulation of protein complex assembly TAS14719143
    GO:0070830tight junction assembly IDA17332497
    GO:0071896protein localization to adherens junction IMP17237226

    MPP7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MPP7

    Search CenterWatch for drugs/clinical trials and news about MPP7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MPP7 gene: 
    NM_173496.3  

    Unigene Cluster for MPP7:

    Membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
    Hs.499159  [show with all ESTs]
    Unigene Representative Sequence: NM_173496
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375732(uc009xkz.1 uc001iub.1 uc009xla.2) ENST00000496637
    ENST00000375719 ENST00000441595 ENST00000481244 ENST00000474731 ENST00000474682
    ENST00000337532(uc001iua.1) ENST00000540098 ENST00000445954(uc010qdv.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPP7
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate MPP7 (see all 23):
    hsa-miR-3673 hsa-miR-181c hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-340 hsa-miR-3658 hsa-miR-532-5p
    SwitchGear 3'UTR luciferase reporter plasmidMPP7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MPP7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPP7
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    OriGene ORF clones in mouse, rat for MPP7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MPP7 (NM_173496)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPP7
    Sirion Biotech Customized lentivirus for stable overexpression of MPP7 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPP7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPP7

    Additional mRNA sequence: 

    AK057360.2 AK130972.1 AK301592.1 AK315046.1 AL832380.1 BC038105.2 

    9 DOTS entries:

    DT.95368746  DT.40211497  DT.100787402  DT.75100424  DT.101956051  DT.95185430  DT.100705424  DT.95368748 
    DT.99970810 

    24/66 AceView cDNA sequences (see all 66):

    BQ774044 AK130972 AA247946 BE887502 BQ435135 CB145141 BU607636 T71146 
    CR623672 AW006286 AI653238 AA322046 BU674299 AA878649 AI034481 BI463778 
    BX378993 BX327781 BX506506 NM_173496 BF056335 D79481 CB242642 AI244661 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MPP7 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^
    SP1:                    -     -                       -     -                                                                 -                       -         
    SP2:              -     -     -     -                 -     -                                                                 -                       -         
    SP3:                                                  -     -                                                                 -                                 
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24a · 24b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for MPP7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MPP7 expression in normal human tissues (normalized intensities)      MPP7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCATCTTGA
    MPP7 Expression
    About this image


    MPP7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Rod Cells Outer Nuclear Layer
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Placenta (Extraembryonic Tissues)

    See MPP7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MPP7

    SOURCE GeneReport for Unigene cluster: Hs.499159
        SABiosciences Custom PCR Arrays for MPP7
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPP7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MPP7 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mpp71 , 5 membrane protein, palmitoylated 7 (MAGUK p55 subfamily more1, 5 87.91(n)1
    92.53(a)1
      18 (4.53 cM)5
    757391  NM_001081287.21  NP_001074756.21 
     73479625 
    chicken
    (Gallus gallus)
    Aves MPP71 membrane protein, palmitoylated 7 (MAGUK p55 subfamily more 84.55(n)
    91.84(a)
      420481  XM_418583.2  XP_418583.2 
    lizard
    (Anolis carolinensis)
    Reptilia MPP76
    Uncharacterized protein
    83(a)
    1 ↔ 1
    6(13982787-14026074)
    zebrafish
    (Danio rerio)
    Actinopterygii hmp2 humpback 76.31(n)   30166  AF124435.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta metro1 menage a trois 49.67(n)
    41.68(a)
      36176  NM_136798.2  NP_610642.2 
    worm
    (Caenorhabditis elegans)
    Secernentea magu-11 Protein MAGU-1 47.26(n)
    39.11(a)
      190302  NM_064800.1  NP_497201.1 


    ENSEMBL Gene Tree for MPP7 (if available)
    TreeFam Gene Tree for MPP7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MPP7 gene
    MPP62  DLG32  MPP52  DLG22  MPP22  MPP42  DLG42  DLG12  
    CASK2  MPP12  MPP32  
    11 SIMAP similar genes for MPP7 using alignment to 2 protein entries:     MPP7_HUMAN (see all proteins):
    MPP3    DKFZp666F1010    MPP5    MPP4    MPP6    DKFZp666D023
    GUK1    MPP2    MPP1    DLG2    CASK

    MPP7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4712 SNPs in MPP7 are shown (see all 4712)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs781567361,2
    C--28339470(+) GAGGT-/CAWGTGT 1 -- ds50010--------
    rs752899341,2
    C--28339471(+) AGGTT-/CAGTGTT 1 -- ds50010--------
    rs37808581,2
    C,F--28339773(-) CCCCAC/TCTCCT 1 -- ds50011Minor allele frequency- T:0.12EA 120
    rs1504117371,2
    --28339822(+) TCTTCC/TTTCCC 1 -- ds50010--------
    rs1844595111,2
    --28339868(+) TATGGA/GTAAGA 1 -- ds50010--------
    rs37808571,2
    C,F,H--28339909(-) TTCATC/GGAGGC 1 -- ds50019Minor allele frequency- G:0.14EA NA NS 1924
    rs1889630431,2
    --28339911(+) CTCGAC/TGAAAG 1 -- ds50010--------
    rs37808561,2
    C,F,A--28340000(-) AAATTA/CTATTT 1 -- ut315Minor allele frequency- C:0.21WA CSA EA 244
    rs1451874461,2
    C--28340234(+) AAGGTC/TATGTT 1 -- ut310--------
    rs1813327131,2
    --28340239(+) TATGTC/TTGTCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MPP7 (28339922 - 28589922 bp, first 250kb of MPP7)

    Structural Variations
         Database of Genomic Variants (DGV) 10/34 variations for MPP7 (see all 34):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2673478CNV Deletion23128226
    esv2669951CNV Deletion23128226
    esv2734772CNV Deletion23290073
    esv2421445CNV Deletion20811451
    esv2661194CNV Deletion23128226
    esv2672420CNV Deletion23128226
    esv2734783CNV Deletion23290073
    esv2734606CNV Deletion23290073
    esv2734794CNV Deletion23290073
    nsv6199CNV Loss18451855


    Human Gene Mutation Database (HGMD): MPP7
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MPP7
    DNA2.0 Custom Variant and Variant Library Synthesis for MPP7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610973    OMIM disorders: --

    4 diseases for MPP7:    About MalaCards
    nephritis    pneumonia    alzheimer's disease    tuberculosis


    MPP7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): MPP7
    Human Genome Epidemiology (HuGE) Navigator: MPP7 (2 documents)

    Export disorders for MPP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MPP7 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with MPP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human MPP7 gene and mouse Mpp7 gene in silico. (PubMed id 14719143)1, 2, 3, 9 Katoh M. and Katoh M. (2004)
    2. Genome-wide association study of Alzheimer's disease w ith psychotic symptoms. (PubMed id 22005930)1, 4 Hollingworth P....Williams J. (2012)
    3. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)1, 4 Furney S.J....Lovestone S. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation. (PubMed id 17332497)1, 2 Stucke V.M....Hall A. (2007)
    6. The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions. (PubMed id 17237226)1, 2 Bohl J.... Vande Pol S.B. (2007)
    7. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    8. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. (PubMed id 16678097)1, 2 Wells C.D.... Pawson T. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. Post-genome wide association studies and functional an alyses identify association of MPP7 gene variants with site-specific bone minera l density. (PubMed id 22171069)1 Xiao S.M....Sham P.C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 143098 HGNC: 26542 AceView: MPP7 Ensembl:ENSG00000150054 euGenes: HUgn143098
    ECgene: MPP7 H-InvDB: MPP7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MPP7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MPP7 gene:
    Search GeneIP for patents involving MPP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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