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Aliases for MPP6 Gene

Aliases for MPP6 Gene

  • Membrane Palmitoylated Protein 6 2 3
  • Membrane Protein, Palmitoylated 6 (MAGUK P55 Subfamily Member 6) 2 3
  • Membrane Protein, Palmitoylated 6 2 5
  • VAM-1 3 4
  • VAM1 3 4
  • Protein Associated With Lin7 2 3
  • VELI-Associated MAGUK 1 3
  • Veli-Associated MAGUK 1 4
  • MAGUK Protein P55T 3
  • PALS2 3
  • P55T 3

External Ids for MPP6 Gene

Previous GeneCards Identifiers for MPP6 Gene

  • GC07P024255
  • GC07P024355
  • GC07P024386
  • GC07P024579
  • GC07P024544

Summaries for MPP6 Gene

Entrez Gene Summary for MPP6 Gene

  • Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM, Mar 2008]

GeneCards Summary for MPP6 Gene

MPP6 (Membrane Palmitoylated Protein 6) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include PDZ domain binding. An important paralog of this gene is CASK.

Gene Wiki entry for MPP6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPP6 Gene

Genomics for MPP6 Gene

Regulatory Elements for MPP6 Gene

Enhancers for MPP6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MPP6 on UCSC Golden Path with GeneCards custom track

Promoters for MPP6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MPP6 on UCSC Golden Path with GeneCards custom track

Genomic Location for MPP6 Gene

24,573,268 bp from pter
24,694,193 bp from pter
120,926 bases
Plus strand

Genomic View for MPP6 Gene

Genes around MPP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPP6 Gene

Proteins for MPP6 Gene

  • Protein details for MPP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MAGUK p55 subfamily member 6
    Protein Accession:
    Secondary Accessions:
    • A4D157
    • Q9H0E1

    Protein attributes for MPP6 Gene

    540 amino acids
    Molecular mass:
    61117 Da
    Quaternary structure:
    • Interacts with CADM1 (By similarity). Interacts with the LIN7 proteins.

neXtProt entry for MPP6 Gene

Proteomics data for MPP6 Gene at MOPED

Post-translational modifications for MPP6 Gene

  • Ubiquitination at Lys 195, Lys 403, Lys 515, and Lys 519
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for MPP6 Gene

Domains & Families for MPP6 Gene

Suggested Antigen Peptide Sequences for MPP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 guanylate kinase-like domain.
  • Belongs to the MAGUK family.
  • Contains 1 guanylate kinase-like domain.
  • Contains 2 L27 domains.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 SH3 domain.
  • Belongs to the MAGUK family.
genes like me logo Genes that share domains with MPP6: view

Function for MPP6 Gene

genes like me logo Genes that share phenotypes with MPP6: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPP6 Gene

Localization for MPP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPP6 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for MPP6 Gene COMPARTMENTS Subcellular localization image for MPP6 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
plasma membrane 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MPP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with MPP6: view

Pathways & Interactions for MPP6 Gene

genes like me logo Genes that share pathways with MPP6: view

Pathways by source for MPP6 Gene

Gene Ontology (GO) - Biological Process for MPP6 Gene


No data available for SIGNOR curated interactions for MPP6 Gene

Drugs & Compounds for MPP6 Gene

No Compound Related Data Available

Transcripts for MPP6 Gene

Unigene Clusters for MPP6 Gene

Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MPP6 Gene

No ASD Table

Relevant External Links for MPP6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPP6 Gene

mRNA expression in normal human tissues for MPP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MPP6 Gene

This gene is overexpressed in Testis (x4.9).

Protein differential expression in normal tissues from HIPED for MPP6 Gene

This gene is overexpressed in Breast (47.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPP6 Gene

SOURCE GeneReport for Unigene cluster for MPP6 Gene Hs.533355

mRNA Expression by UniProt/SwissProt for MPP6 Gene

Tissue specificity: Abundant in testis, brain, and kidney with lower levels detectable in other tissues.
genes like me logo Genes that share expression patterns with MPP6: view

Primer Products

No data available for Protein tissue co-expression partners for MPP6 Gene

Orthologs for MPP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for MPP6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MPP6 35
  • 94.01 (n)
  • 99.07 (a)
MPP6 36
  • 97 (a)
(Canis familiaris)
Mammalia MPP6 35
  • 94.81 (n)
  • 99.63 (a)
MPP6 36
  • 98 (a)
(Mus musculus)
Mammalia Mpp6 35
  • 90.6 (n)
  • 98.33 (a)
Mpp6 16
Mpp6 36
  • 96 (a)
(Pan troglodytes)
Mammalia MPP6 35
  • 99.63 (n)
  • 100 (a)
MPP6 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mpp6 35
  • 90.37 (n)
  • 97.41 (a)
(Monodelphis domestica)
Mammalia MPP6 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia MPP6 36
  • 90 (a)
(Gallus gallus)
Aves MPP6 35
  • 84.51 (n)
  • 95.74 (a)
MPP6 36
  • 94 (a)
(Anolis carolinensis)
Reptilia MPP6 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mpp6 35
  • 77.61 (n)
  • 87.2 (a)
Str.17662 35
(Danio rerio)
Actinopterygii mpp6a 35
  • 69.58 (n)
  • 76.35 (a)
zgc55662 35
mpp6a 36
  • 74 (a)
mpp6b 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9326 37
  • 39 (a)
skf 37
  • 39 (a)
vari 35
  • 48.22 (n)
  • 43.89 (a)
vari 36
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008321 35
  • 53.32 (n)
  • 50.1 (a)
(Caenorhabditis elegans)
Secernentea Y55B1BR.4 37
  • 29 (a)
Species with no ortholog for MPP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPP6 Gene

Gene Tree for MPP6 (if available)
Gene Tree for MPP6 (if available)

Paralogs for MPP6 Gene

Paralogs for MPP6 Gene

genes like me logo Genes that share paralogs with MPP6: view

Variants for MPP6 Gene

Sequence variations from dbSNP and Humsavar for MPP6 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs767421 -- 24,652,712(+) TTTGC(C/G)TCTTC intron-variant
rs886794 -- 24,670,002(-) GGCAG(A/G)GGAAG intron-variant
rs917265 -- 24,649,588(-) GCCTG(C/T)GGTTA intron-variant
rs929401 -- 24,649,772(-) TATCT(A/G)TACTC intron-variant
rs985062 -- 24,576,855(-) CTCTG(C/T)GGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPP6 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv526721 CNV Loss 19592680
nsv518495 CNV Loss 19592680
nsv527599 CNV Gain 19592680
esv998133 CNV Deletion 20482838
esv2434979 CNV Deletion 19546169
esv2168364 CNV Deletion 18987734
esv4910 CNV Deletion 18987735
esv996504 CNV Deletion 20482838
esv2734136 CNV Deletion 23290073
esv1546433 CNV Deletion 17803354
esv8712 CNV Loss 19470904
nsv520276 CNV Gain 19592680

Variation tolerance for MPP6 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPP6 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPP6 Gene

Disorders for MPP6 Gene

Relevant External Links for MPP6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MPP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPP6 Gene

Publications for MPP6 Gene

  1. VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain. (PMID: 11311936) Tseng T.-C. … Chishti A.H. (Biochim. Biophys. Acta 2001) 2 3 4 23 67
  2. Molecular cloning and characterization of Pals, proteins associated with mLin-7. (PMID: 10753959) Kamberov E. … Margolis B. (J. Biol. Chem. 2000) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for MPP6 Gene

Sources for MPP6 Gene