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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MPP4 Gene

protein-coding GIFtS: 50
GCID: GC02M202509

membrane protein, palmitoylated 4 (MAGUK p55 subfamily member...

(Previous symbol: DLG6)

Explore 9 diseases affiliated with
MPP4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Membrane Protein, Palmitoylated 4 (MAGUK P55 Subfamily Member 4)¹ ²		ALS2CR5² ³
DLG6¹ ² ³ ⁵		Discs, Large Homolog 6²
Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 5 Protein² ³		MAGUK P55 Subfamily Member 4²
Discs Large Homolog 6² ³

External Ids:	HGNC: 13680¹	Entrez Gene: 58538²	Ensembl: ENSG00000082126⁷	OMIM: 606575⁵	UniProtKB: Q96JB8³

Export aliases for MPP4 gene to outside databases

Previous GC identifers: GC02M200726 GC02M201234 GC02M202473 GC02M202712 GC02M202335 GC02M202217 GC02M194357

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MPP4:

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) protein family, with an N-terminal PDZ

domain, a central src homology 3 region (SH3), and a C-terminal guanylate kinase-like (GUK) domain. The protein is

localized to the outer limiting membrane in the retina, and is thought to function in photoreceptor polarity and the

organization of specialized intercellular junctions. Alternatively spliced transcript variants have been described,

but their biological validity has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MPP4_HUMAN, Q96JB8

Function: May play a role in retinal photoreceptors development (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MPP4 gene promoter:
SRF GR RP58 GATA-3 AML1a SRF (504 AA) FOXJ2 (long isoform) STAT3 GR-alpha FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MPP4 promoter sequence

Search SABiosciences Chromatin IP Primers for MPP4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPP4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.2 Ensembl cytogenetic band: 2q33.1 HGNC cytogenetic band: 2q33.2

MPP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPP4 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M202509: view genomic region (about GC identifiers)

Start:	202,509,593 bp from pter	End:	202,563,417 bp from pter
Size:	53,825 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MPP4_HUMAN, Q96JB8 (See protein sequence)

Recommended Name: MAGUK p55 subfamily member 4

Size: 637 amino acids; 72779 Da

Subunit: Interacts with MPDZ. May interact with GRIA2 (By similarity). Forms a complex with CRB1 and MPP5. Interacts

with FASLG

Subcellular location: Cytoplasm. Note=Detected at the outer limiting membrane (OLM) and in the outer plexiform layer

(OPL) of the retina. At the OLM, detected apical to the adherens junction (AJ)

Secondary accessions: C9IZK4 Q53TT3 Q6ZNH6 Q96Q43 Q96Q44

Alternative splicing: 5 isoforms: Q96JB8-1 Q96JB8-2 Q96JB8-3 Q96JB8-4 Q96JB8-5

Explore the universe of human proteins at neXtProt for MPP4: NX_Q96JB8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96JB8

MPP4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_149055.1

ENSEMBL proteins:

ENSP00000386580 ENSP00000387278 ENSP00000319363 ENSP00000380095 ENSP00000416781

ENSP00000387293 ENSP00000406160 ENSP00000353047

Human Recombinant Protein Products for MPP4:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MPP4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0042734	presynaptic membrane	IEA	--

MPP4 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for MPP4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MPP4 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR008144 Guanylate_kin

IPR008145 Guanylate_kin/L-typ_Ca_channel

IPR014775 L27_C

IPR001452 SH3_domain

IPR001478 PDZ

Graphical View of Domain Structure for InterPro Entry Q96JB8

ProtoNet protein and cluster: Q96JB8

5 Blocks protein families:

IPB001452 SH3 domain signature

IPB001478 PDZ/DHR/GLGF domain

IPB004172 L27 domain

IPB008144 Guanylate kinase

IPB011511 Variant SH3

UniProtKB/Swiss-Prot: MPP4_HUMAN, Q96JB8

Similarity: Belongs to the MAGUK family

Similarity: Contains 1 guanylate kinase-like domain

Similarity: Contains 2 L27 domains

Similarity: Contains 1 PDZ (DHR) domain

Similarity: Contains 1 SH3 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MPP4_HUMAN, Q96JB8

Function: May play a role in retinal photoreceptors development (By similarity)

Phenotypes:
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mpp4):

cellular

nervous system

vision/eye

MPP4 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for MPP4: Mpp4^tm1Tili Mpp4^tm1Wij

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MPP4

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPP4
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate MPP4:
		hsa-miR-3143 hsa-miR-338-3p
		SwitchGear 3'UTR luciferase reporter plasmid: MPP4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPP4 (see all 7) OriGene shRNA RFP: MPP4 OriGene siRNA: MPP4
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPP4 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPP4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MPP4

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/13 Interacting proteins for MPP4 (Q96JB8³ ENSP00000387278⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MPP5	Q8N3R9³, ENSP00000261681⁴	I2D: score=1 STRING: ENSP00000261681
FASLG	P48023³, ENSP00000356694⁴	I2D: score=1 STRING: ENSP00000356694
CXCR2	P25025³	I2D: score=1
GRIA2	P42262³	I2D: score=1
SF3A2	ENSP00000221494⁴	STRING: ENSP00000221494

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0035418	protein localization to synapse	IEA	--

MPP4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MPP4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MPP4
1 Novoseek chemical compound relationship for MPP4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
guanylate	61.1	3	15914641 (1), 18955048 (1)

Search CenterWatch for drugs/clinical trials and news about MPP4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MPP4 gene:

NM_033066.2

Unigene Cluster for MPP4:

Membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)

Hs.63085 [show with all ESTs]

Unigene Representative Sequence: BX647162

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409818(uc002uyi.4 uc002uyl.4) ENST00000409474(uc010ftj.3 uc010zhq.2 uc002uyk.4)

ENST00000315506(uc010ftk.3) ENST00000396886(uc010zhs.2 uc002uyj.4)

ENST00000428900(uc010zht.2 uc010zhr.2) ENST00000409143 ENST00000447335

ENST00000486212(uc002uym.1) ENST00000483841(uc002uyn.3) ENST00000359962

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPP4
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate MPP4:
		hsa-miR-3143 hsa-miR-338-3p
		SwitchGear 3'UTR luciferase reporter plasmid: MPP4 3' UTR sequence

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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPP4
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		GenScript: all cDNA clones in your preferred vector: MPP4 (NM_033066)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPP4
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Additional cDNA sequence:

AB053302.1 AB053303.1 AB053304.1 AF316032.1 AK131208.1 AK298589.1 AK298947.1 AK300622.1

BC132785.1 BC144206.1 BX647162.1 BX648531.1 DQ426883.1

10 DOTS entries:

DT.102830715 DT.100738383 DT.101967793 DT.100742379 DT.101973395 DT.121028097 DT.91912448 DT.307629

DT.95157344 DT.97824998

24/67 AceView cDNA sequences (see all 67):

CD634687 AB053302 CK299856 BX648531 BX093612 NM_033066 AF316032 BQ188381

BM999928 BQ001206 BI868629 AL711954 BX647162 CB219611 AA015777 CK299855

AL712749 AL711768 AB053303 CD634692 BX491120 AL711534 AK131208 CB219734

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for MPP4 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12a	·	12b	·	12c	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20
SP1:					-		-																						-				-
SP2:					-		-										-		-
SP3:																																	-
SP4:							-
SP5:																	-		-

ECgene alternative splicing isoforms for MPP4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MPP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCTTTTTAA

About this image

MPP4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Outer Nuclear Layer

Mature Rod Cells

Photoreceptors, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

CD31, CD144 positive cells (Two-step protocol fo...)

See MPP4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MPP4

SOURCE GeneReport for Unigene cluster: Hs.63085

UniProtKB/Swiss-Prot: MPP4_HUMAN, Q96JB8

Tissue specificity: Expressed in the retina (at protein level). Highly expressed in the retina. Lower amounts are

detected in brain, testis, ARPE-19, RPE/choroid and fetal eye. Isoform 5 is retina-specific

SABiosciences Custom PCR Arrays for MPP4

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPP4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for MPP4 gene from 8/30 species (see all 30) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MPP4¹	membrane protein, palmitoylated 4 (MAGUK p55 subfamily more	74.59(n) 74.75(a)		769757 XM_001233046.1 XP_001233047.1
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	74(a) 68(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	GL343478.1(162212-186112) GL344565.1(6101-23422)
zebrafish (Danio rerio)	Actinopterygii	LOC556594¹	MAGUK p55 subfamily member 4-like	62.03(n) 59.08(a)		556594 XM_679434.4 XP_684526.4
fruit fly (Drosophila melanogaster)	Insecta	metro⁶ CG11811⁶	--	36(a) 23(a)	1 ↔ many possible ortholog	2R(7113962-7120056) 3L(10684124-10685698)
worm (Caenorhabditis elegans)	Secernentea	guk-1⁶ Y55B1BR.4⁶	Protein Y55B1BR.4	25(a) 25(a)	possible ortholog possible ortholog	I(3859381-3862732) III(464865-471694)
thale cress (Arabidopsis thaliana)	eudicotyledons	GK-1⁶ AT3G06200⁶ (see all 3)	guanylate kinase (see all 3)	17(a) 17(a) (see all 3)	possible ortholog possible ortholog (see all 3)	2(17474619-17477223) 3(1877594-1879348)
rice (Oryza sativa)	Liliopsida	-- --	guanylate kinase, putative, expressed	17(a) 17(a)	possible ortholog possible ortholog	12(20000190-20004313) 3(11594171-11597778)
E. coli (Escherichia coli)	Gamma proteobacteria	gmk⁶	guanylate kinase	25(a)	possible ortholog	Chromosome(3819451-3820074)

ENSEMBL Gene Tree for MPP4 (if available)
TreeFam Gene Tree for MPP4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MPP4 gene

MPP6² MPP7² DLG3² MPP5² DLG2² MPP2² DLG4² DLG1²

CASK² MPP1² MPP3²

18/19 SIMAP similar genes for MPP4 using alignment to 9 protein entries: MPP4_HUMAN (see all proteins) (see all similar genes):

C4orf22 EIF3L NF2 CERS5 FAM175A AURA2

GLT8D2 MPP7 DKFZp666D023 MPP3 LINC00596 DKFZp666F1010

DLG2 GUK1 MPP5 MPP6 DKFZp761P0818 MPP2

MPP4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114208884^1,2	C,F	--	194357873(+)	`GTTAAA/GATAGG`	1	--	ut3¹		1		WA	118
rs1012165^1,2	C,F	--	194359048(-)	`TCTTTG/AGTTTT`	1	--	int¹		5		NA EA WA	450
rs12105848^1,2		--	194359246(+)	`ATTAAA/GTTCAT`	1	--	int¹		0	--	--	--	--
rs111275745^1,2	C	--	194359967(+)	`ACCGG-/AAAAAA`	1	--	int¹		1		CSA	2
rs201626364^1,2	C	--	194359967(+)	`ACCGGA/GAAAAA`	1	--	int¹		0	--	--	--	--
rs77554472^1,2		--	194360293(+)	`TAAGGA/GCATTA`	1	--	int¹		0	--	--	--	--
rs116490188^1,2	C,F	--	194361140(+)	`GGCATG/AAGCCA`	1	--	int¹		1		WA	118
rs75372779^1,2	F	--	194361607(+)	`TGACTA/GAGAAA`	1	--	int¹		1		WA	118
rs78118616^1,2	F	--	194362271(+)	`CACGTT/CAAGTA`	1	--	int¹		1		WA	118
rs59974307^1,2	C	--	194362738(+)	`TTCTGC/TTCCCT`	1	--	int¹		2		WA	120

HapMap Linkage Disequilibrium report for MPP4 (202509593 - 202563417 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MPP4
2 CNVs: 90223 78939

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MPP4 for disorders           About GeneDecksing

OMIM gene information: 606575    OMIM disorders: --

9 diseases for MPP4:    About MalaCards

amyotrophic lateral sclerosis lateral sclerosis retinitis pigmentosa retinitis

choroiditis pneumonia tuberculosis malaria

mycobacterium tuberculosis

2 Novoseek disease relationships for MPP4 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinitis pigmentosa	62.1	2	12384283 (2)
retinopathy	35	1	15914641 (1)

Human Genome Epidemiology (HuGE) Navigator: MPP4 (5 documents)

Export disorders for MPP4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MPP4 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with MPP4)

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Cloning and characterization of the human retina-specific gene MPP4, a novel member of the p55 subfamily of MAGUK proteins. (PubMed id 11414766)^{1, 2, 3} Stoehr H. and Weber B.H.F. (2001)
MPP5 recruits MPP4 to the CRB1 complex in photoreceptors. (PubMed id 15914641)^{1, 2, 9} Kantardzhieva A.... Wijnholds J. (2005)
Characterization of MPP4, a gene highly expressed in photoreceptor cells, and mutation analysis in retinitis pigmentosa. (PubMed id 12384283)^{1, 2, 9} Conte I.... Ciccodicola A. (2002)
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)^{1, 2} Voss M....Janssen O. (2009)
Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina. (PubMed id 15558731)^{1, 2} Stoehr H.... Kraemer F. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. (PubMed id 11586298)^{1, 2} Hadano S....Ikeda J.-E. (2001)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Mapping of transcription start sites of human retina expressed genes. (PubMed id 17286855)¹ Roni V.... Wissinger B. (2007)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 58538	HGNC: 13680	AceView: MPP4	Ensembl:ENSG00000082126	euGenes: HUgn58538
ECgene: MPP4	H-InvDB: MPP4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MPP4	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MPP4

Intellectual Property for MPP4 gene
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Patent Information for MPP4 gene:
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GeneCards and IP:
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