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Aliases for MPP3 Gene

Aliases for MPP3 Gene

  • Membrane Protein, Palmitoylated 3 (MAGUK P55 Subfamily Member 3) 2 3
  • DLG3 3 4 6
  • Membrane Protein Palmitoylated 3 2 3
  • MAGUK P55 Subfamily Member 3 2 3
  • Discs Large Homolog 3 3 4
  • Large (Drosophila) Homolog 3 2
  • Discs, Large Homolog 3 3
  • Protein MPP3 4
  • Discs 2

External Ids for MPP3 Gene

Previous HGNC Symbols for MPP3 Gene

  • DLG3

Previous GeneCards Identifiers for MPP3 Gene

  • GC17M041620
  • GC17M044055
  • GC17M041888
  • GC17M042353
  • GC17M039233
  • GC17M037642

Summaries for MPP3 Gene

Entrez Gene Summary for MPP3 Gene

  • This gene product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. This protein contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. Alternatively spliced transcript variants have been identified. One transcript variant is experimentally supported, but it doesn't encode a protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MPP3 Gene

MPP3 (Membrane Protein, Palmitoylated 3 (MAGUK P55 Subfamily Member 3)) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include PDZ domain binding and guanylate kinase activity. An important paralog of this gene is MPP6.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPP3 Gene

Genomics for MPP3 Gene

Regulatory Elements for MPP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MPP3 Gene

43,800,799 bp from pter
43,833,179 bp from pter
32,381 bases
Minus strand

Genomic View for MPP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPP3 Gene

Proteins for MPP3 Gene

  • Protein details for MPP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MAGUK p55 subfamily member 3
    Protein Accession:
    Secondary Accessions:
    • B2R7N0
    • D3DX47
    • Q4GX05
    • Q6PGR3
    • Q86SV1

    Protein attributes for MPP3 Gene

    585 amino acids
    Molecular mass:
    66152 Da
    Quaternary structure:
    • May interact with HTR2A (By similarity). Interacts (via PDZ domain) with CADM1 (via C-terminus). Interacts with HTR4 (By similarity).
    • Sequence=AAH47017.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MPP3 Gene

Proteomics data for MPP3 Gene at MOPED

Post-translational modifications for MPP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MPP3 Gene

No data available for DME Specific Peptides for MPP3 Gene

Domains for MPP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q13368
  • Contains 1 guanylate kinase-like domain.
  • Contains 2 L27 domains.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 SH3 domain.
  • Belongs to the MAGUK family.
genes like me logo Genes that share domains with MPP3: view

No data available for Gene Families for MPP3 Gene

Function for MPP3 Gene

Molecular function for MPP3 Gene

GENATLAS Biochemistry: membrane protein,palmitoylated 3,66kDa,involved in coupling the cytoskeleton to the cell membrane

Gene Ontology (GO) - Molecular Function for MPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004385 guanylate kinase activity TAS 8824795
GO:0005515 protein binding --
GO:0030165 PDZ domain binding IEA --
genes like me logo Genes that share ontologies with MPP3: view
genes like me logo Genes that share phenotypes with MPP3: view

Animal Model Products

CRISPR Products

miRNA for MPP3 Gene

miRTarBase miRNAs that target MPP3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MPP3 Gene

Localization for MPP3 Gene

Subcellular locations from

Jensen Localization Image for MPP3 Gene COMPARTMENTS Subcellular localization image for MPP3 gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for MPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8824795
genes like me logo Genes that share ontologies with MPP3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MPP3 Gene

Pathways for MPP3 Gene

genes like me logo Genes that share pathways with MPP3: view

Pathways by source for MPP3 Gene

Gene Ontology (GO) - Biological Process for MPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8824795
GO:0046939 nucleotide phosphorylation TAS 8824795
genes like me logo Genes that share ontologies with MPP3: view

Compounds for MPP3 Gene

(1) Novoseek inferred chemical compound relationships for MPP3 Gene

Compound -log(P) Hits PubMed IDs
atp 14.2 1
genes like me logo Genes that share compounds with MPP3: view

Transcripts for MPP3 Gene

Unigene Clusters for MPP3 Gene

Membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
SP1: - - -
SP4: -

ExUns: 21

Relevant External Links for MPP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPP3 Gene

mRNA expression in normal human tissues for MPP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MPP3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (6.3), Brain - Cerebellum (5.8), Heart - Atrial Appendage (5.7), and Heart - Left Ventricle (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MPP3 Gene

SOURCE GeneReport for Unigene cluster for MPP3 Gene Hs.396566

genes like me logo Genes that share expressions with MPP3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MPP3 Gene

Orthologs for MPP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MPP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MPP3 35
  • 99.6 (n)
  • 99.66 (a)
MPP3 36
  • 100 (a)
(Bos Taurus)
Mammalia MPP3 36
  • 93 (a)
(Canis familiaris)
Mammalia MPP3 35
  • 89.9 (n)
  • 94.69 (a)
MPP3 36
  • 90 (a)
(Mus musculus)
Mammalia Mpp3 35
  • 87.29 (n)
  • 90.94 (a)
Mpp3 16
Mpp3 36
  • 91 (a)
(Monodelphis domestica)
Mammalia MPP3 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Mpp3 35
  • 86.38 (n)
  • 90.43 (a)
(Gallus gallus)
Aves MPP3 35
  • 72.71 (n)
  • 79.45 (a)
MPP3 36
  • 79 (a)
(Anolis carolinensis)
Reptilia MPP3 36
  • 77 (a)
(Danio rerio)
Actinopterygii LOC572079 35
  • 67.07 (n)
  • 71.23 (a)
MPP3 (1 of 2) 36
  • 70 (a)
MPP3 (2 of 2) 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta metro 36
  • 38 (a)
skf 37
  • 38 (a)
(Caenorhabditis elegans)
Secernentea magu-1 36
  • 29 (a)
Y55B1BR.4 37
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for MPP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MPP3 Gene

Gene Tree for MPP3 (if available)
Gene Tree for MPP3 (if available)

Paralogs for MPP3 Gene

Paralogs for MPP3 Gene

Selected SIMAP similar genes for MPP3 Gene using alignment to 3 proteins: Pseudogenes for MPP3 Gene

genes like me logo Genes that share paralogs with MPP3: view

Variants for MPP3 Gene

Sequence variations from dbSNP and Humsavar for MPP3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1034636 -- 43,804,341(+) aagaa(C/T)agaca intron-variant
rs1063149 -- 43,820,891(-) GCCGG(A/C)CTCAT synonymous-codon, reference, nc-transcript-variant, missense, intron-variant
rs1230384 -- 43,832,465(+) CCCAA(C/G)CCAAA intron-variant
rs1237669 -- 43,834,656(+) tagaa(G/T)aaaac upstream-variant-2KB
rs1859048 -- 43,814,671(+) tacaa(A/C)tacta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPP3 Gene

Variant ID Type Subtype PubMed ID
nsv908265 CNV Gain 21882294
nsv908267 CNV Gain 21882294

Relevant External Links for MPP3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPP3 Gene

Disorders for MPP3 Gene

(1) Novoseek inferred disease relationships for MPP3 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1
genes like me logo Genes that share disorders with MPP3: view

No data available for UniProtKB/Swiss-Prot for MPP3 Gene

Publications for MPP3 Gene

  1. Isolation of a gene (DLG3) encoding a second member of the discs- large family on chromosome 17q12-q21. (PMID: 8824795) Smith S.A. … Albertsen H. (Genomics 1996) 2 3 4
  2. Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg. (PMID: 13679854) Fukuhara H. … Murakami Y. (Oncogene 2003) 3 4
  3. An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies. (PMID: 15123239) Boisguerin P. … Volkmer-Engert R. (Chem. Biol. 2004) 3
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for MPP3 Gene

  • Addgene plasmids for MPP3

Sources for MPP3 Gene

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