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Aliases for MPP3 Gene

Aliases for MPP3 Gene

  • Membrane Palmitoylated Protein 3 2 3
  • Membrane Protein, Palmitoylated 3 (MAGUK P55 Subfamily Member 3) 2 3
  • Membrane Protein, Palmitoylated 3 2 5
  • Membrane Protein Palmitoylated 3 2 3
  • Discs Large Homolog 3 3 4
  • DLG3 3 4
  • MAGUK P55 Subfamily Member 3 2
  • Large (Drosophila) Homolog 3 2
  • Discs, Large Homolog 3 3
  • Protein MPP3 4
  • Discs 2

External Ids for MPP3 Gene

Previous HGNC Symbols for MPP3 Gene

  • DLG3

Previous GeneCards Identifiers for MPP3 Gene

  • GC17M041620
  • GC17M044055
  • GC17M041888
  • GC17M042353
  • GC17M039233
  • GC17M037642

Summaries for MPP3 Gene

Entrez Gene Summary for MPP3 Gene

  • This gene product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. This protein contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. Alternatively spliced transcript variants have been identified. One transcript variant is experimentally supported, but it doesn't encode a protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MPP3 Gene

MPP3 (Membrane Palmitoylated Protein 3) is a Protein Coding gene. Diseases associated with MPP3 include Chromosome 3Q29 Microdeletion Syndrome and Allan-Herndon-Dudley Syndrome. GO annotations related to this gene include PDZ domain binding and guanylate kinase activity. An important paralog of this gene is MPP6.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPP3 Gene

Genomics for MPP3 Gene

Regulatory Elements for MPP3 Gene

Enhancers for MPP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MPP3 on UCSC Golden Path with GeneCards custom track

Promoters for MPP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MPP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MPP3 Gene

43,800,799 bp from pter
43,833,179 bp from pter
32,381 bases
Minus strand

Genomic View for MPP3 Gene

Genes around MPP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPP3 Gene

Proteins for MPP3 Gene

  • Protein details for MPP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MAGUK p55 subfamily member 3
    Protein Accession:
    Secondary Accessions:
    • B2R7N0
    • D3DX47
    • Q4GX05
    • Q6PGR3
    • Q86SV1

    Protein attributes for MPP3 Gene

    585 amino acids
    Molecular mass:
    66152 Da
    Quaternary structure:
    • May interact with HTR2A (By similarity). Interacts (via PDZ domain) with CADM1 (via C-terminus). Interacts with HTR4 (By similarity).
    • Sequence=AAH47017.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MPP3 Gene

Proteomics data for MPP3 Gene at MOPED

Post-translational modifications for MPP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MPP3 Gene

No data available for DME Specific Peptides for MPP3 Gene

Domains & Families for MPP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 guanylate kinase-like domain.
  • Belongs to the MAGUK family.
  • Contains 1 guanylate kinase-like domain.
  • Contains 2 L27 domains.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 SH3 domain.
  • Belongs to the MAGUK family.
genes like me logo Genes that share domains with MPP3: view

Function for MPP3 Gene

Molecular function for MPP3 Gene

GENATLAS Biochemistry:
membrane protein,palmitoylated 3,66kDa,involved in coupling the cytoskeleton to the cell membrane

Gene Ontology (GO) - Molecular Function for MPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with MPP3: view
genes like me logo Genes that share phenotypes with MPP3: view

Animal Model Products

miRNA for MPP3 Gene

miRTarBase miRNAs that target MPP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPP3 Gene

Localization for MPP3 Gene

Subcellular locations from

Jensen Localization Image for MPP3 Gene COMPARTMENTS Subcellular localization image for MPP3 gene
Compartment Confidence
cytosol 4
plasma membrane 4
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MPP3 Gene

Pathways & Interactions for MPP3 Gene

SuperPathways for MPP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8824795
GO:0046710 GDP metabolic process TAS 8824795
genes like me logo Genes that share ontologies with MPP3: view

No data available for Pathways by source and SIGNOR curated interactions for MPP3 Gene

Drugs & Compounds for MPP3 Gene

(1) Drugs for MPP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MPP3: view

Transcripts for MPP3 Gene

Unigene Clusters for MPP3 Gene

Membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MPP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
SP1: - - -
SP4: -

ExUns: 21

Relevant External Links for MPP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPP3 Gene

mRNA expression in normal human tissues for MPP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MPP3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.3), Brain - Cerebellum (x5.8), Heart - Atrial Appendage (x5.7), and Heart - Left Ventricle (x5.2).

Protein differential expression in normal tissues from HIPED for MPP3 Gene

This gene is overexpressed in Fetal Brain (60.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MPP3 Gene

SOURCE GeneReport for Unigene cluster for MPP3 Gene Hs.396566

genes like me logo Genes that share expression patterns with MPP3: view

Protein tissue co-expression partners for MPP3 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MPP3 Gene

Orthologs for MPP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MPP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia MPP3 35
  • 89.9 (n)
  • 94.69 (a)
MPP3 36
  • 90 (a)
(Mus musculus)
Mammalia Mpp3 35
  • 87.29 (n)
  • 90.94 (a)
Mpp3 16
Mpp3 36
  • 91 (a)
(Pan troglodytes)
Mammalia MPP3 35
  • 99.6 (n)
  • 99.66 (a)
MPP3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mpp3 35
  • 86.38 (n)
  • 90.43 (a)
(Bos Taurus)
Mammalia MPP3 36
  • 93 (a)
(Monodelphis domestica)
Mammalia MPP3 36
  • 87 (a)
(Gallus gallus)
Aves MPP3 35
  • 72.71 (n)
  • 79.45 (a)
MPP3 36
  • 79 (a)
(Anolis carolinensis)
Reptilia MPP3 36
  • 77 (a)
(Danio rerio)
Actinopterygii LOC572079 35
  • 67.07 (n)
  • 71.23 (a)
MPP3 (1 of 2) 36
  • 70 (a)
MPP3 (2 of 2) 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta skf 37
  • 38 (a)
metro 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea Y55B1BR.4 37
  • 30 (a)
magu-1 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for MPP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MPP3 Gene

Gene Tree for MPP3 (if available)
Gene Tree for MPP3 (if available)

Paralogs for MPP3 Gene

Paralogs for MPP3 Gene

(11) SIMAP similar genes for MPP3 Gene using alignment to 3 proteins: Pseudogenes for MPP3 Gene

genes like me logo Genes that share paralogs with MPP3: view

Variants for MPP3 Gene

Sequence variations from dbSNP and Humsavar for MPP3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs17742683 - 43,801,706(+) TTACC(C/T)GACCC nc-transcript-variant, reference, missense
rs1034636 -- 43,804,341(+) aagaa(C/T)agaca intron-variant
rs1063149 -- 43,820,891(-) GCCGG(A/C)CTCAT nc-transcript-variant, reference, synonymous-codon, missense
rs1859048 -- 43,814,671(+) tacaa(A/C)tacta intron-variant
rs1859049 -- 43,814,960(+) caact(A/G)gtgaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPP3 Gene

Variant ID Type Subtype PubMed ID
nsv908265 CNV Gain 21882294
nsv908267 CNV Gain 21882294

Variation tolerance for MPP3 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.28; 70.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPP3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPP3 Gene

Disorders for MPP3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MPP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 3q29 microdeletion syndrome
  • 3q subtelomere deletion syndrome
allan-herndon-dudley syndrome
  • allan-herndon syndrome
- elite association - COSMIC cancer census association via MalaCards
Search MPP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MPP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MPP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MPP3 Gene

Publications for MPP3 Gene

  1. Isolation of a gene (DLG3) encoding a second member of the discs- large family on chromosome 17q12-q21. (PMID: 8824795) Smith S.A. … Albertsen H. (Genomics 1996) 2 3 4 67
  2. Dynamic regulation of a cell adhesion protein complex including CADM1 by combinatorial analysis of FRAP with exponential curve-fitting. (PMID: 25780926) Sakurai-Yageta M. … Murakami Y. (PLoS ONE 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Trans-homophilic interaction of CADM1 activates PI3K by forming a complex with MAGuK-family proteins MPP3 and Dlg. (PMID: 24503895) Murakami S. … Murakami Y. (PLoS ONE 2014) 3
  5. Membrane palmitoylated protein 3 promotes hepatocellular carcinoma cell migration and invasion via up-regulating matrix metalloproteinase 1. (PMID: 24513266) Ma H. … Yu L. (Cancer Lett. 2014) 3

Products for MPP3 Gene

Sources for MPP3 Gene