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MPP3 Gene

protein-coding   GIFtS: 57
GCID: GC17M041888

Membrane Protein, Palmitoylated 3 (MAGUK P55 Subfamily Member...


(Previous symbol: DLG3)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane Protein, Palmitoylated 3 (MAGUK P55 Subfamily Member 3)1 2     discs1
DLG31 2 3 5     Large (Drosophila) Homolog 31
MAGUK P55 Subfamily Member 31 2     Discs, Large Homolog 32
Membrane Protein Palmitoylated 31 2     Protein MPP33
Discs Large Homolog 32 3     

External Ids:    HGNC: 72211   Entrez Gene: 43562   Ensembl: ENSG000001616477   OMIM: 6011145   UniProtKB: Q133683   

Export aliases for MPP3 gene to outside databases

Previous GC identifers: GC17M041620 GC17M044055 GC17M042353 GC17M039233 GC17M037642


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MPP3 Gene:
This gene product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated
guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling
pathways, and intracellular junctions. This protein contains a conserved sequence, called the SH3 (src homology
3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play
important roles in signal transduction. Alternatively spliced transcript variants have been identified. One
transcript variant is experimentally supported, but it doesn't encode a protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for MPP3 Gene:
MPP3 (membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)) is a protein-coding gene. Diseases associated with MPP3 include intellectual disability, and pneumonia. GO annotations related to this gene include PDZ domain binding and guanylate kinase activity. An important paralog of this gene is MPP7.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MPP3 gene promoter:
         Elk-1   AML1a   Pax-6   Lmo2   Nkx2-5   AREB6   IRF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMPP3 promoter sequence
   Search Chromatin IP Primers for MPP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MPP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q12-q21

MPP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPP3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M041888:  view genomic region     (about GC identifiers)

Start:
41,878,167 bp from pter      End:
41,910,547 bp from pter
Size:
32,381 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MPP3_HUMAN, Q13368 (See protein sequence)
Recommended Name: MAGUK p55 subfamily member 3  
Size: 585 amino acids; 66152 Da
Subunit: May interact with HTR2A (By similarity). Interacts (via PDZ domain) with CADM1 (via C-terminus).
Interacts with HTR4 (By similarity)
Sequence caution: Sequence=AAH47017.1; Type=Erroneous initiation;
Secondary accessions: B2R7N0 D3DX47 Q4GX05 Q6PGR3 Q86SV1

Explore the universe of human proteins at neXtProt for MPP3: NX_Q13368

Explore proteomics data for MPP3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MPP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001923.2  
    ENSEMBL proteins: 
     ENSP00000381430   ENSP00000465486   ENSP00000381425   ENSP00000467453  

    MPP3 Human Recombinant Protein Products:

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    Novus Biologicals MPP3 Protein
    Novus Biologicals MPP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MPP3

    MPP3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for MPP3

    MPP3 Assay Products:

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    Cloud-Clone Corp. ELISAs for MPP3
    Cloud-Clone Corp. CLIAs for MPP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR008144 Guanylate_kin-like
     IPR008145 GK/Ca_channel_bsu
     IPR014775 L27_C
     IPR001452 SH3_domain
     IPR011511 SH3_2

    Graphical View of Domain Structure for InterPro Entry Q13368

    ProtoNet protein and cluster: Q13368

    5 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB001478 PDZ/DHR/GLGF domain
    IPB004172 L27 domain
    IPB008144 Guanylate kinase
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: MPP3_HUMAN, Q13368
    Similarity: Belongs to the MAGUK family
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 2 L27 domains
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 SH3 domain


    MPP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for MPP3:
    membrane protein,palmitoylated 3,66kDa,involved in coupling the cytoskeleton to the cell membrane

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004385guanylate kinase activity TAS8824795
    GO:0005515protein binding ----
    GO:0030165PDZ domain binding IEA--
         
    MPP3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MPP3:
     Increased cell death HMECs cel  Small cells  Upregulation of Wnt/beta-caten 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mpp3):
     cellular  nervous system  vision/eye 

    MPP3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MPP3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MPP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MPP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MPP3

    miRNA
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    miRTarBase miRNAs that target MPP3:
    hsa-mir-615-3p (MIRT040203), hsa-mir-335-5p (MIRT017838), hsa-mir-186-5p (MIRT045183)

    Block miRNA regulation of human, mouse, rat MPP3 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate MPP3:
    hsa-miR-203 hsa-miR-145* hsa-miR-9 hsa-miR-1263 hsa-miR-520d-5p hsa-miR-186 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidMPP3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MPP3
    Predesigned siRNA for gene silencing in human, mouse, rat MPP3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MPP3

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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MPP3 (NM_001932)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPP3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MPP3
    Browse ESI BIO Cell Lines and PureStem Progenitors for MPP3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol3
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS8824795

    MPP3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MPP3
    Interactions:

        GeneGlobe Interaction Network for MPP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for MPP3 (Q133682, 3 ENSP000003814254) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNG7O602622, 3MINT-64781 I2D: score=5 
    MCM2P497362, 3MINT-64785 I2D: score=5 
    MDH1P409252, 3MINT-64784 I2D: score=5 
    NOA1Q8NC602, 3MINT-64792 I2D: score=5 
    PLK2Q9NYY32, 3MINT-64796 I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8824795
    GO:0046939nucleotide phosphorylation TAS8824795

    MPP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MPP3

    1 Novoseek inferred chemical compound relationship for MPP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 14.2 1 14744991 (1)



    MPP3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MPP3 gene: 
    NM_001932.4  

    Unigene Cluster for MPP3:

    Membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
    Hs.396566  [show with all ESTs]
    Unigene Representative Sequence: U37707
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398393(uc002ieh.3 uc002iei.4 uc002iej.3 uc010czi.2)
    ENST00000496503 ENST00000398389(uc010wik.2 uc010czj.2) ENST00000486600
    ENST00000466083 ENST00000475450 ENST00000479797 ENST00000589375 ENST00000480958

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MPP3 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate MPP3:
    hsa-miR-203 hsa-miR-145* hsa-miR-9 hsa-miR-1263 hsa-miR-520d-5p hsa-miR-186 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidMPP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MPP3
    Predesigned siRNA for gene silencing in human, mouse, rat MPP3
    Clone
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    OriGene clones in human, mouse for MPP3 (see all 6)
    OriGene ORF clones in mouse, rat for MPP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MPP3 (NM_001932)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPP3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MPP3
    OriGene qSTAR qPCR primer pairs in human, mouse for MPP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MPP3
      QuantiTect SYBR Green Assays in human, mouse, rat MPP3
      QuantiFast Probe-based Assays in human, mouse, rat MPP3

    Additional mRNA sequence: 

    AK299535.1 AK309045.1 AK311368.1 AK313045.1 AM050144.1 AM050145.1 BC025743.1 BC035833.1 
    BC047017.1 BC056865.1 NR_003562.2 U37707.1 

    12 DOTS entries:

    DT.95364790  DT.101979630  DT.311724  DT.91664935  DT.40266796  DT.75150032  DT.40230225  DT.100829277 
    DT.99971581  DT.120907113  DT.311725  DT.97780778 

    Selected AceView cDNA sequences (see all 52):

    AI300965 BC047017 T27220 BM968956 BC056865 AI049956 BF061922 AW292372 
    BX094255 BE669711 BU634174 T27219 NM_001932 BE550837 AW955726 T27221 
    BC035833 AI223415 R92906 BI820136 U37707 BX403899 AI654561 AA365800 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MPP3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
    SP1:                    -                                         -                                         -                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                    -                                                                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 21
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for MPP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MPP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTGAAAGG
    MPP3 Expression
    About this image


    MPP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neurons
             Adult Dopaminergic Neurons Ventral Tegmental Area
     
     Kidney (Urinary System)
             Metanephros
     
     Eye (Sensory Organs)
             Retina
     
     Brain (Nervous System)
             Adult Dopaminergic Neurons Ventral Tegmental Area
    MPP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MPP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.396566
        Custom PCR Arrays for MPP3
    Primer
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    OriGene qPCR primer pairs and template standards for MPP3
    OriGene qSTAR qPCR primer pairs in human, mouse for MPP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MPP3
    QuantiTect SYBR Green Assays in human, mouse, rat MPP3
    QuantiFast Probe-based Assays in human, mouse, rat MPP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MPP3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mpp31 , 5 membrane protein, palmitoylated 3 (MAGUK p55 subfamily more1, 5 87.29(n)1
    90.94(a)1
      11 (65.48 cM)5
    133841  NM_007863.21  NP_031889.21 
     1019996525 
    chicken
    (Gallus gallus)
    Aves MPP31 membrane protein, palmitoylated 3 (MAGUK p55 subfamily more 72.71(n)
    79.45(a)
      419985  XM_418108.4  XP_418108.3 
    lizard
    (Anolis carolinensis)
    Reptilia MPP36
    membrane protein, palmitoylated 3 (MAGUK p55 subfa...
    77(a)
    1 ↔ 1
    6(78192292-78264547)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5720791 MAGUK p55 subfamily member 3-like 67.07(n)
    71.23(a)
      572079  XM_695746.5  XP_700838.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta skf3 guanylate kinase 38(a)   47E1   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y55B1BR.43   -- 30(a)   III(464865-471694)   --


    ENSEMBL Gene Tree for MPP3 (if available)
    TreeFam Gene Tree for MPP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MPP3 gene
    MPP72  DLG32  MPP62  MPP52  DLG22  MPP22  MPP42  DLG42  
    DLG12  CASK2  MPP12  
    11 SIMAP similar genes for MPP3 using alignment to 3 protein entries:     MPP3_HUMAN (see all proteins):
    MPP7    MPP4    DKFZp666F1010    MPP5    GUK1    MPP1
    DKFZp761P0818    MPP6    MPP2    DKFZp666D023    CASK

    MPP3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MPP3
    PGOHUM00000247999 PGOHUM00000246194


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MPP3 (see all 695)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1139196361,2
    C,F--41877740(+) ACAAGA/CACACA 2 -- ds50012Minor allele frequency- C:0.25WA NA 122
    rs1479580871,2
    C--41877757(+) TGCCCA/GGCTAG 2 -- ds50010--------
    rs1489970051,2
    --41877947(+) ACTGTC/TTAAGC 2 -- ds50010--------
    rs717867211,2
    C--41878115(+) CACCTAAGA/-  
            
    TATAT
    2 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs169402161,2
    C,F--41878126(+) TATCAT/CGAATC 2 -- ds50017Minor allele frequency- C:0.12NA WA 264
    rs80778891,2
    C,F,H--41878166(+) AACCCA/CTTAGG 2 -- ds500116Minor allele frequency- C:0.17NS EA NA WA CSA 1866
    rs1909138161,2
    --41878386(+) GGCTCA/GATGTT 2 -- nc-transcript-variantut310--------
    rs1450600881,2
    --41878529(+) TTTACA/GTATAT 2 -- nc-transcript-variantut310--------
    rs1867411211,2
    --41878592(+) TCAAAA/GAAAAG 2 -- nc-transcript-variantut310--------
    rs739851101,2
    C--41878701(+) CGTCAC/TTATGT 2 -- nc-transcript-variantut312Minor allele frequency- T:0.21WA 120

    HapMap Linkage Disequilibrium report for MPP3 (41878167 - 41910547 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MPP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908265CNV Gain21882294
    nsv908267CNV Gain21882294

    Human Gene Mutation Database (HGMD): MPP3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MPP3
    DNA2.0 Custom Variant and Variant Library Synthesis for MPP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601114    OMIM disorders: --

    6 diseases for MPP3:    
    About MalaCards
    intellectual disability    pneumonia    tuberculosis    retinitis
    cervicitis    neuronitis


    MPP3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MPP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 16282525 (1)


    Export disorders for MPP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MPP3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with MPP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a gene (DLG3) encoding a second member of the discs- large family on chromosome 17q12-q21. (PubMed id 8824795)1, 2, 3 Smith S.A.... Albertsen H. (Genomics 1996)
    2. Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg. (PubMed id 13679854)1, 2 Fukuhara H.... Murakami Y. (Oncogene 2003)
    3. Membrane palmitoylated protein 3 promotes hepatocellular carcinoma cell migration and invasion via up-regulating matrix metalloproteinase 1. (PubMed id 24513266)1 Ma H....Yu L. (Cancer Lett. 2014)
    4. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    5. MPP3 inactivation by promoter CpG islands hypermethylation in colorectal carcinogenesis. (PubMed id 23011156)1 Feng X....Zhou Y. (Cancer Biomark 2012)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. [The growth inhibition effects of TSLC1 gene on human hepatocyte carcinoma cell line HepG2]. (PubMed id 17669239)1 Qin L....Yang D.L. (Zhonghua Gan Zang Bing Za Zhi 2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane. (PubMed id 16519681)1 Kantardzhieva A....Wijnholds J. (FEBS J. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 4356 HGNC: 7221 AceView: MPP3 Ensembl:ENSG00000161647 euGenes: HUgn4356
    ECgene: MPP3 H-InvDB: MPP3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MPP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MPP3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MPP3 gene:
    Search GeneIP for patents involving MPP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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