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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MPP3 Gene

protein-coding GIFtS: 56
GCID: GC17M041888

membrane protein, palmitoylated 3 (MAGUK p55 subfamily member...

(Previous symbol: DLG3)

Explore 7 diseases affiliated with
MPP3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Membrane Protein, Palmitoylated 3 (MAGUK P55 Subfamily Member 3)¹ ²		MAGUK P55 Subfamily Member 3²
DLG3¹ ² ³ ⁵		Membrane Protein Palmitoylated 3²
Discs Large Homolog 3² ³		Protein MPP3³
Discs, Large Homolog 3²

External Ids:	HGNC: 7221¹	Entrez Gene: 4356²	Ensembl: ENSG00000161647⁷	OMIM: 601114⁵	UniProtKB: Q13368³

ORGUL members:
	NONCODE:n406139

Export aliases for MPP3 gene to outside databases

Previous GC identifers: GC17M041620 GC17M044055 GC17M042353 GC17M039233 GC17M037642

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MPP3:

This gene product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate

kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and

intracellular junctions. This protein contains a conserved sequence, called the SH3 (src homology 3) motif, found in

several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal

transduction. Alternatively spliced transcript variants have been identified. One transcript variant is experimentally

supported, but it doesn't encode a protein. (provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MPP3 gene promoter:
Elk-1 AML1a Pax-6 Lmo2 Nkx2-5 AREB6 IRF-2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MPP3 promoter sequence

Search SABiosciences Chromatin IP Primers for MPP3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPP3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q12-q21

MPP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPP3 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M041888: view genomic region (about GC identifiers)

Start:	41,878,167 bp from pter	End:	41,910,547 bp from pter
Size:	32,381 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MPP3_HUMAN, Q13368 (See protein sequence)

Recommended Name: MAGUK p55 subfamily member 3

Size: 585 amino acids; 66152 Da

Subunit: May interact with HTR2A (By similarity). Interacts (via PDZ domain) with CADM1 (via C-terminus). Interacts

with HTR4 (By similarity)

Sequence caution: Sequence=AAH47017.1; Type=Erroneous initiation;

Secondary accessions: B2R7N0 D3DX47 Q4GX05 Q6PGR3 Q86SV1

Explore the universe of human proteins at neXtProt for MPP3: NX_Q13368

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13368

MPP3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001923.2

ENSEMBL proteins:

ENSP00000381430 ENSP00000465486 ENSP00000381425 ENSP00000467453

Human Recombinant Protein Products for MPP3:

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	Novus Biologicals MPP3 Protein Novus Biologicals MPP3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MPP3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	8824795
GO:0009986	cell surface	IDA	12493773

MPP3 for ontologies About GeneDecksing

MPP3 Antibody Products:

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	Uscn ELISAs and CLIAs for MPP3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MPP3 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR008144 Guanylate_kin

IPR008145 Guanylate_kin/L-typ_Ca_channel

IPR014775 L27_C

IPR001452 SH3_domain

IPR011511 SH3_2

Graphical View of Domain Structure for InterPro Entry Q13368

ProtoNet protein and cluster: Q13368

5 Blocks protein families:

IPB001452 SH3 domain signature

IPB001478 PDZ/DHR/GLGF domain

IPB004172 L27 domain

IPB008144 Guanylate kinase

IPB011511 Variant SH3

UniProtKB/Swiss-Prot: MPP3_HUMAN, Q13368

Similarity: Belongs to the MAGUK family

Similarity: Contains 1 guanylate kinase-like domain

Similarity: Contains 2 L27 domains

Similarity: Contains 1 PDZ (DHR) domain

Similarity: Contains 1 SH3 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

Genatlas biochemistry entry for MPP3:

membrane protein,palmitoylated 3,66kDa,involved in coupling the cytoskeleton to the cell membrane

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004385	guanylate kinase activity	TAS	8824795
GO:0030165	PDZ domain binding	IEA	--

MPP3 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for MPP3:

Increased cell death HMECs cel

Small cells

Upregulation of Wnt/beta-caten

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MPP3

miRNA Products:		OriGene 3'-UTR Clone: MPP3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPP3
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate MPP3:
		hsa-miR-203 hsa-miR-145* hsa-miR-9 hsa-miR-1263 hsa-miR-520d-5p hsa-miR-186 hsa-miR-524-5p
		SwitchGear 3'UTR luciferase reporter plasmid: MPP3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPP3 (see all 4) OriGene shRNA RFP: MPP3 OriGene siRNA: MPP3
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPP3 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPP3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MPP3 (NM_001932)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MPP3

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/41 Interacting proteins for MPP3 (Q13368^{2, 3} ENSP00000381425⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 41)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNG7	O60262²^,³	MINT-64781 I2D: score=5
MCM2	P49736²^,³	MINT-64785 I2D: score=5
MDH1	P40925²^,³	MINT-64784 I2D: score=5
NOA1	Q8NC60²^,³	MINT-64792 I2D: score=5
PLK2	Q9NYY3²^,³	MINT-64796 I2D: score=5

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	8824795

MPP3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MPP3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MPP3
1 Novoseek chemical compound relationship for MPP3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
atp	14.2	1	14744991 (1)

Search CenterWatch for drugs/clinical trials and news about MPP3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MPP3 gene:

NM_001932.4

Unigene Cluster for MPP3:

Membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)

Hs.396566 [show with all ESTs]

Unigene Representative Sequence: U37707

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000398393(uc002ieh.3 uc002iei.4 uc002iej.3 uc010czi.2)

ENST00000496503 ENST00000398389(uc010wik.2 uc010czj.2) ENST00000486600

ENST00000466083 ENST00000475450 ENST00000479797 ENST00000589375 ENST00000480958

miRNA Products:		OriGene 3'-UTR Clone: MPP3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPP3
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate MPP3:
		hsa-miR-203 hsa-miR-145* hsa-miR-9 hsa-miR-1263 hsa-miR-520d-5p hsa-miR-186 hsa-miR-524-5p
		SwitchGear 3'UTR luciferase reporter plasmid: MPP3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPP3 (see all 4) OriGene shRNA RFP: MPP3 OriGene siRNA: MPP3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPP3
		Sirion Biotech Custom design and validation of potent shRNA sequences against MPP3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPP3 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPP3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MPP3 (NM_001932)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPP3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPP3

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPP3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPP3

Additional cDNA sequence:

AK299535.1 AK309045.1 AK311368.1 AK313045.1 AM050144.1 AM050145.1 BC025743.1 BC035833.1

BC047017.1 BC056865.1 NR_003562.2 U37707.1

12 DOTS entries:

DT.95364790 DT.101979630 DT.311724 DT.91664935 DT.40266796 DT.75150032 DT.40230225 DT.100829277

DT.99971581 DT.120907113 DT.311725 DT.97780778

24/52 AceView cDNA sequences (see all 52):

BC047017 BC056865 AW955726 AI049956 BF061922 BX094255 NM_001932 BE669711

T27219 BU634174 BC035833 BM968956 BE550837 AI300965 T27220 T27221

AW292372 AA323846 AL709604 BI838192 W44684 AL134657 AI792733 BI820136

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MPP3 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20a	·	20b	^
SP1:							-														-														-
SP2:
SP3:
SP4:							-
SP5:

ExUns:	21
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MPP3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MPP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTGAAAGG

About this image

MPP3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Eye

Kidney

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MPP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MPP3

SOURCE GeneReport for Unigene cluster: Hs.396566

SABiosciences Custom PCR Arrays for MPP3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPP3 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPP3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for MPP3 gene from 8/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MPP3¹	membrane protein, palmitoylated 3 (MAGUK p55 subfamily more	72.71(n) 79.45(a)		419985 XM_418108.3 XP_418108.3
lizard (Anolis carolinensis)	Reptilia	MPP3⁶ -- (see all 3)	--	76(a) 35(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	6(78192298-78248557) GL344565.1(6101-23422)
zebrafish (Danio rerio)	Actinopterygii	LOC572079¹	MAGUK p55 subfamily member 3-like	67.01(n) 71.13(a)		572079 XM_695746.4 XP_700838.4
fruit fly (Drosophila melanogaster)	Insecta	skf³	guanylate kinase	38(a)		47E1 --
worm (Caenorhabditis elegans)	Secernentea	Y55B1BR.4³	--	30(a)		III(464865-471694) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G06200⁶ GK-1⁶ (see all 3)	guanylate kinase 1 (see all 3)	17(a) 17(a) (see all 3)	possible ortholog possible ortholog (see all 3)	3(1877594-1879348) 2(17474619-17477223)
rice (Oryza sativa)	Liliopsida	-- --	guanylate kinase, putative, expressed	16(a) 16(a)	possible ortholog possible ortholog	3(11594171-11597778) 12(20000190-20004313)
E. coli (Escherichia coli)	Gamma proteobacteria	gmk⁶	guanylate kinase	24(a)	possible ortholog	Chromosome(3819451-3820074)

ENSEMBL Gene Tree for MPP3 (if available)
TreeFam Gene Tree for MPP3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MPP3 gene

MPP6² MPP7² DLG3² MPP5² DLG2² MPP2² MPP4² DLG4²

DLG1² CASK² MPP1²

11 SIMAP similar genes for MPP3 using alignment to 3 protein entries: MPP3_HUMAN (see all proteins):

MPP7 MPP4 DKFZp666F1010 MPP5 GUK1 MPP1

DKFZp761P0818 MPP6 MPP2 DKFZp666D023 CASK

MPP3 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for MPP3
PGOHUM00000247999 PGOHUM00000246194

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113919636^1,2	C	--	41877740(+)	`ACAAGA/CACACA`	2	--	ds500¹		2		WA NA	122
rs147958087^1,2		--	41877757(+)	`TGCCCA/GGCTAG`	2	--	ds500¹		0	--	--	--	--
rs148997005^1,2		--	41877947(+)	`ACTGTC/TTAAGC`	2	--	ds500¹		0	--	--	--	--
rs71786721^1,2	C	--	41878115(+)	`CACCTAAGA/- TATAT`	2	--	ds500¹		1		CSA	2
rs16940216^1,2	C,F	--	41878126(+)	`TATCAT/CGAATC`	2	--	ds500¹		7		NA WA	264
rs8077889^1,2	C,F,H	--	41878166(+)	`AACCCA/CTTAGG`	2	--	ds500¹		16		NS EA NA WA CSA	1866
rs190913816^1,2		--	41878386(+)	`GGCTCA/GATGTT`	2	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs145060088^1,2		--	41878529(+)	`TTTACA/GTATAT`	2	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs186741121^1,2		--	41878592(+)	`TCAAAA/GAAAAG`	2	--	nc-transcript-variantut3¹		0	--	--	--	--
rs73985110^1,2	C	--	41878701(+)	`CGTCAC/TTATGT`	2	--	ut3¹ nc-transcript-variant		2		WA	120

HapMap Linkage Disequilibrium report for MPP3 (41878167 - 41910547 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MPP3: --
Human Gene Mutation Database (HGMD): MPP3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPP3

DNA2.0 Custom Variant and Variant Library Synthesis for MPP3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MPP3 for disorders           About GeneDecksing

OMIM gene information: 601114    OMIM disorders: --

7 diseases for MPP3:    About MalaCards

intellectual disability pneumonia retinitis tuberculosis

malaria carcinoma mycobacterium tuberculosis

1 Novoseek disease relationship for MPP3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	1	16282525 (1)

Export disorders for MPP3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MPP3 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with MPP3)

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Isolation of a gene (DLG3) encoding a second member of the discs- large family on chromosome 17q12-q21. (PubMed id 8824795)^{1, 2, 3} Smith S.A.... Albertsen H. (1996)
Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg. (PubMed id 13679854)^{1, 2} Fukuhara H.... Murakami Y. (2003)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
[The growth inhibition effects of TSLC1 gene on human hepatocyte carcinoma cell line HepG2] (PubMed id 17669239)¹ Qin L....Yang D.L. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane. (PubMed id 16519681)¹ Kantardzhieva A....Wijnholds J. (2006)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. (PubMed id 12493773)¹ Shin B.K....Hanash S.M. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4356	HGNC: 7221	AceView: MPP3	Ensembl:ENSG00000161647	euGenes: HUgn4356
ECgene: MPP3	H-InvDB: MPP3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MPP3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MPP3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MPP3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MPP3 gene:
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