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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MPP3 Gene

protein-coding   GIFtS: 56
GCID: GC17M041888

membrane protein, palmitoylated 3 (MAGUK p55 subfamily member...


(Previous symbol: DLG3)
 Explore 7 diseases affiliated with
MPP3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MPP3    

Aliases
for MPP3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Membrane Protein, Palmitoylated 3 (MAGUK P55 Subfamily Member 3)1 2     MAGUK P55 Subfamily Member 32
DLG31 2 3 5     Membrane Protein Palmitoylated 32
Discs Large Homolog 32 3     Protein MPP33
Discs, Large Homolog 32     

External Ids:    HGNC: 72211   Entrez Gene: 43562   Ensembl: ENSG000001616477   OMIM: 6011145   UniProtKB: Q133683   
ORGUL members:         
NONCODE:n406139    

Export aliases for MPP3 gene to outside databases

Previous GC identifers: GC17M041620 GC17M044055 GC17M042353 GC17M039233 GC17M037642


Summaries
for MPP3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MPP3:
This gene product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate
kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and
intracellular junctions. This protein contains a conserved sequence, called the SH3 (src homology 3) motif, found in
several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal
transduction. Alternatively spliced transcript variants have been identified. One transcript variant is experimentally
supported, but it doesn't encode a protein. (provided by RefSeq, Jul 2008)




Genomic Views
for MPP3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MPP3 gene promoter:
         Elk-1   AML1a   Pax-6   Lmo2   Nkx2-5   AREB6   IRF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MPP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MPP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q12-q21

MPP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPP3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M041888:  view genomic region     (about GC identifiers)

Start:
 41,878,167 bp from pter      End:
 41,910,547 bp from pter
Size:
 32,381 bases      Orientation:
 minus strand

Proteins
for MPP3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MPP3_HUMAN, Q13368 (See protein sequence)
Recommended Name: MAGUK p55 subfamily member 3  
Size: 585 amino acids; 66152 Da
Subunit: May interact with HTR2A (By similarity). Interacts (via PDZ domain) with CADM1 (via C-terminus). Interacts
with HTR4 (By similarity)
Sequence caution: Sequence=AAH47017.1; Type=Erroneous initiation;
Secondary accessions: B2R7N0 D3DX47 Q4GX05 Q6PGR3 Q86SV1

Explore the universe of human proteins at neXtProt for MPP3: NX_Q13368

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13368

    • MPP3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001923.2  
    ENSEMBL proteins: 
     ENSP00000381430   ENSP00000465486   ENSP00000381425   ENSP00000467453  

    Human Recombinant Protein Products: 
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    Novus Biologicals MPP3 Protein
    Novus Biologicals MPP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MPP3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS8824795
    GO:0009986cell surface IDA12493773


    MPP3 for ontologies           About GeneDecksing



    MPP3 Antibody Products: 
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    Uscn Antibodies for MPP3
    ThermoFisher Antibodies for MPP3

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    Uscn ELISAs and CLIAs for MPP3

    Protein Domains /
    Families
    for MPP3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MPP3 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR008144 Guanylate_kin
     IPR008145 Guanylate_kin/L-typ_Ca_channel
     IPR014775 L27_C
     IPR001452 SH3_domain
     IPR011511 SH3_2

    Graphical View of Domain Structure for InterPro Entry Q13368

    ProtoNet protein and cluster: Q13368

    5 Blocks protein families:
    IPB001452 SH3 domain signature
    IPB001478 PDZ/DHR/GLGF domain
    IPB004172 L27 domain
    IPB008144 Guanylate kinase
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: MPP3_HUMAN, Q13368
    Similarity: Belongs to the MAGUK family
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 2 L27 domains
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 SH3 domain


    Function
    for MPP3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for MPP3:
    membrane protein,palmitoylated 3,66kDa,involved in coupling the cytoskeleton to the cell membrane

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MPP3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPP3
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MPP3:
    hsa-miR-203 hsa-miR-145* hsa-miR-9 hsa-miR-1263 hsa-miR-520d-5p hsa-miR-186 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MPP3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPP3 (see all 4)
    OriGene shRNA RFP: MPP3
    OriGene siRNA: MPP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPP3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MPP3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPP3 (see all 2)
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    GenScript: all cDNA clones in your preferred vector: MPP3 (NM_001932)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPP3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MPP3
    Search LifeMap BioReagents cell lines for MPP3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP3

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004385guanylate kinase activity TAS8824795
    GO:0030165PDZ domain binding IEA--


    MPP3 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for MPP3:
     Increased cell death HMECs cel  Small cells  Upregulation of Wnt/beta-caten 


    Pathways & Interactions
    for MPP3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MPP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/41 Interacting proteins for MPP3 (Q133682, 3 ENSP000003814254) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNG7O602622, 3MINT-64781 I2D: score=5 
    MCM2P497362, 3MINT-64785 I2D: score=5 
    MDH1P409252, 3MINT-64784 I2D: score=5 
    NOA1Q8NC602, 3MINT-64792 I2D: score=5 
    PLK2Q9NYY32, 3MINT-64796 I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8824795


    MPP3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MPP3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MPP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MPP3
    1 Novoseek chemical compound relationship for MPP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 14.2 1 14744991 (1)

    Search CenterWatch for drugs/clinical trials and news about MPP3 

    Transcripts
    for MPP3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MPP3 gene: 
    NM_001932.4  

    Unigene Cluster for MPP3:

    Membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
    Hs.396566  [show with all ESTs]
    Unigene Representative Sequence: U37707
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398393(uc002ieh.3 uc002iei.4 uc002iej.3 uc010czi.2)
    ENST00000496503 ENST00000398389(uc010wik.2 uc010czj.2) ENST00000486600
    ENST00000466083 ENST00000475450 ENST00000479797 ENST00000589375 ENST00000480958


    miRNA
    Products:             		 OriGene 3'-UTR Clone: MPP3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPP3
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MPP3:
    hsa-miR-203 hsa-miR-145* hsa-miR-9 hsa-miR-1263 hsa-miR-520d-5p hsa-miR-186 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MPP3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPP3 (see all 4)
    OriGene shRNA RFP: MPP3
    OriGene siRNA: MPP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPP3
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPP3
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    GenScript: all cDNA clones in your preferred vector: MPP3 (NM_001932)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPP3 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MPP3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPP3

    Additional cDNA sequence: 

    AK299535.1 AK309045.1 AK311368.1 AK313045.1 AM050144.1 AM050145.1 BC025743.1 BC035833.1 
    BC047017.1 BC056865.1 NR_003562.2 U37707.1 

    12 DOTS entries:

    DT.95364790  DT.101979630  DT.311724  DT.91664935  DT.40266796  DT.75150032  DT.40230225  DT.100829277 
    DT.99971581  DT.120907113  DT.311725  DT.97780778 

    24/52 AceView cDNA sequences (see all 52):

    BC047017 BC056865 AW955726 AI049956 BF061922 BX094255 NM_001932 BE669711 
    T27219 BU634174 BC035833 BM968956 BE550837 AI300965 T27220 T27221 
    AW292372 AA323846 AL709604 BI838192 W44684 AL134657 AI792733 BI820136 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MPP3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
    SP1:                    -                                         -                                         -                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                    -                                                                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 21
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for MPP3

    Expression
    for MPP3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MPP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTTGAAAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MPP3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    EyeRetinaEye
    KidneyMetanephrosKidney
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MPP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MPP3

    SOURCE GeneReport for Unigene cluster: Hs.396566
        SABiosciences Custom PCR Arrays for MPP3
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPP3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP3

    Orthologs
    for MPP3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for MPP3 gene from 8/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MPP31 membrane protein, palmitoylated 3 (MAGUK p55 subfamily more 72.71(n)
    79.45(a)    		   419985  XM_418108.3  XP_418108.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MPP36
    --
    (see all 3)    		 --
    		 76(a)
    35(a)
    (see all 3)    		 1 ↔ 1
    possible ortholog
    (see all 3)    		 6(78192298-78248557)
    GL344565.1(6101-23422)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5720791 MAGUK p55 subfamily member 3-like 67.01(n)
    71.13(a)    		   572079  XM_695746.4  XP_700838.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta skf3 guanylate kinase 38(a)   47E1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y55B1BR.43   -- 30(a)   III(464865-471694)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G062006
    GK-16
    (see all 3)    		 guanylate kinase 1
    (see all 3)    		 17(a)
    17(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 3(1877594-1879348)
    2(17474619-17477223)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 guanylate kinase, putative, expressed
    		 16(a)
    16(a)
    		 possible ortholog
    possible ortholog
    		 3(11594171-11597778)
    12(20000190-20004313)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria gmk6
    		 guanylate kinase
    		 24(a)
    		 possible ortholog
    		 Chromosome(3819451-3820074)


    ENSEMBL Gene Tree for MPP3 (if available)
    TreeFam Gene Tree for MPP3 (if available) 

    Paralogs
    for MPP3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MPP3 gene
    MPP62  MPP72  DLG32  MPP52  DLG22  MPP22  MPP42  DLG42  
    DLG12  CASK2  MPP12  
    11 SIMAP similar genes for MPP3 using alignment to 3 protein entries:     MPP3_HUMAN (see all proteins):
    MPP7    MPP4    DKFZp666F1010    MPP5    GUK1    MPP1
    DKFZp761P0818    MPP6    MPP2    DKFZp666D023    CASK

    MPP3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MPP3
    PGOHUM00000247999 PGOHUM00000246194


    Genomic Variants
    for MPP3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/491 NCBI SNPs in MPP3 are shown (see all 491)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1139196361,2
    		C,--41877740(+) ACAAGA/CACACA 2 -- ds50012Minor allele frequency- C:0.25WA NA 122
    rs1479580871,2
    		--41877757(+) TGCCCA/GGCTAG 2 -- ds50010--------
    rs1489970051,2
    		--41877947(+) ACTGTC/TTAAGC 2 -- ds50010--------
    rs717867211,2
    		C,--41878115(+) CACCTAAGA/-  
                TATAT     		2 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs169402161,2
    		C,F,--41878126(+) TATCAT/CGAATC 2 -- ds50017Minor allele frequency- C:0.12NA WA 264
    rs80778891,2
    		C,F,H,--41878166(+) AACCCA/CTTAGG 2 -- ds500116Minor allele frequency- C:0.17NS EA NA WA CSA 1866
    rs1909138161,2
    		--41878386(+) GGCTCA/GATGTT 2 -- ut31 nc-transcript-variant0--------
    rs1450600881,2
    		--41878529(+) TTTACA/GTATAT 2 -- ut31 nc-transcript-variant0--------
    rs1867411211,2
    		--41878592(+) TCAAAA/GAAAAG 2 -- nc-transcript-variantut310--------
    rs739851101,2
    		C,--41878701(+) CGTCAC/TTATGT 2 -- ut31 nc-transcript-variant2Minor allele frequency- T:0.21WA 120

    HapMap Linkage Disequilibrium report for MPP3 (41878167 - 41910547 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MPP3: --
    Human Gene Mutation Database (HGMD): MPP3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPP3
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    Disorders / Diseases
    for MPP3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MPP3 for disorders           About GeneDecksing

    OMIM gene information: 601114    OMIM disorders: --

    7 diseases for MPP3:    About MalaCards
    intellectual disability    pneumonia    retinitis    tuberculosis
    malaria    carcinoma    mycobacterium tuberculosis

    1 Novoseek disease relationship for MPP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 16282525 (1)


    Export disorders for MPP3 gene to outside databases

    Publications
    for MPP3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MPP3 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with MPP3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a gene (DLG3) encoding a second member of the discs- large family on chromosome 17q12-q21. (PubMed id 8824795)1, 2, 3 Smith S.A.... Albertsen H. (1996)
    2. Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg. (PubMed id 13679854)1, 2 Fukuhara H.... Murakami Y. (2003)
    3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    4. [The growth inhibition effects of TSLC1 gene on human hepatocyte carcinoma cell line HepG2] (PubMed id 17669239)1 Qin L....Yang D.L. (2007)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane. (PubMed id 16519681)1 Kantardzhieva A....Wijnholds J. (2006)
    7. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. (PubMed id 12493773)1 Shin B.K....Hanash S.M. (2003)

    External Searches for MPP3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MPP3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4356 HGNC: 7221 AceView: MPP3 Ensembl:ENSG00000161647 euGenes: HUgn4356
    ECgene: MPP3 H-InvDB: MPP3

    Other Databases showing MPP3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MPP3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MPP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MPP3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MPP3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MPP3 gene:
    Search GeneIP for patents involving MPP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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