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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MPP3 Gene

protein-coding   GIFtS: 58
GCID: GC17M041888

Membrane Protein, Palmitoylated 3 (MAGUK P55 Subfamily Member...


(Previous symbol: DLG3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Membrane Protein, Palmitoylated 3 (MAGUK P55 Subfamily Member 3)1 2     discs1
DLG31 2 3 5     Large (Drosophila) Homolog 31
MAGUK P55 Subfamily Member 31 2     Discs, Large Homolog 32
Membrane Protein Palmitoylated 31 2     Protein MPP33
Discs Large Homolog 32 3     

External Ids:    HGNC: 72211   Entrez Gene: 43562   Ensembl: ENSG000001616477   OMIM: 6011145   UniProtKB: Q133683   
ORGUL members:         
NONCODE14:n406139      

Export aliases for MPP3 gene to outside databases

Previous GC identifers: GC17M041620 GC17M044055 GC17M042353 GC17M039233 GC17M037642


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MPP3 Gene:
This gene product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated
guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling
pathways, and intracellular junctions. This protein contains a conserved sequence, called the SH3 (src homology
3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play
important roles in signal transduction. Alternatively spliced transcript variants have been identified. One
transcript variant is experimentally supported, but it doesn't encode a protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for MPP3 Gene: 
MPP3 (membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with MPP3 include intellectual disability, and pneumonia. GO annotations related to this gene include PDZ domain binding and guanylate kinase activity. An important paralog of this gene is MPP6.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MPP3 gene promoter:
         Elk-1   AML1a   Pax-6   Lmo2   Nkx2-5   AREB6   IRF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMPP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MPP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q12-q21

MPP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPP3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M041888:  view genomic region     (about GC identifiers)

Start:
41,878,167 bp from pter      End:
41,910,547 bp from pter
Size:
32,381 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MPP3_HUMAN, Q13368 (See protein sequence)
Recommended Name: MAGUK p55 subfamily member 3  
Size: 585 amino acids; 66152 Da
Subunit: May interact with HTR2A (By similarity). Interacts (via PDZ domain) with CADM1 (via C-terminus).
Interacts with HTR4 (By similarity)
Sequence caution: Sequence=AAH47017.1; Type=Erroneous initiation;
Secondary accessions: B2R7N0 D3DX47 Q4GX05 Q6PGR3 Q86SV1

Explore the universe of human proteins at neXtProt for MPP3: NX_Q13368

Explore proteomics data for MPP3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13368

  • MPP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MPP3 Protein Expression
    REFSEQ proteins: NP_001923.2  
    ENSEMBL proteins: 
     ENSP00000381430   ENSP00000465486   ENSP00000381425   ENSP00000467453  

    Human Recombinant Protein Products for MPP3: 
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    OriGene Protein Over-expression Lysate for MPP3
    OriGene MassSpec for MPP3 
    OriGene Custom Protein Services for MPP3
    GenScript Custom Purified and Recombinant Proteins Services for MPP3
    Novus Biologicals MPP3 Protein
    Novus Biologicals MPP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MPP3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS8824795
    GO:0009986cell surface IDA12493773

    MPP3 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for MPP3 
    Cloud-Clone Corp. CLIAs for MPP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/9 InterPro protein domains (see all 9):
     IPR008144 Guanylate_kin
     IPR008145 Guanylate_kin/L-typ_Ca_channel
     IPR014775 L27_C
     IPR001452 SH3_domain
     IPR011511 SH3_2

    Graphical View of Domain Structure for InterPro Entry Q13368

    ProtoNet protein and cluster: Q13368

    5 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB001478 PDZ/DHR/GLGF domain
    IPB004172 L27 domain
    IPB008144 Guanylate kinase
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: MPP3_HUMAN, Q13368
    Similarity: Belongs to the MAGUK family
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 2 L27 domains
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 SH3 domain


    MPP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for MPP3:
    membrane protein,palmitoylated 3,66kDa,involved in coupling the cytoskeleton to the cell membrane

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004385guanylate kinase activity TAS8824795
    GO:0005515protein binding ----
    GO:0030165PDZ domain binding IEA--
         
    MPP3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MPP3:
     Increased cell death HMECs cel  Small cells  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MPP3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MPP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MPP3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MPP3 

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MPP3:
    hsa-miR-203 hsa-miR-145* hsa-miR-9 hsa-miR-1263 hsa-miR-520d-5p hsa-miR-186 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidMPP3 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MPP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/41 Interacting proteins for MPP3 (Q133682, 3 ENSP000003814254) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNG7O602622, 3MINT-64781 I2D: score=5 
    MCM2P497362, 3MINT-64785 I2D: score=5 
    MDH1P409252, 3MINT-64784 I2D: score=5 
    NOA1Q8NC602, 3MINT-64792 I2D: score=5 
    PLK2Q9NYY32, 3MINT-64796 I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8824795

    MPP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MPP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MPP3

    1 Novoseek inferred chemical compound relationship for MPP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 14.2 1 14744991 (1)

    Search CenterWatch for drugs/clinical trials and news about MPP3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MPP3 gene: 
    NM_001932.4  

    Unigene Cluster for MPP3:

    Membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
    Hs.396566  [show with all ESTs]
    Unigene Representative Sequence: U37707
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398393(uc002ieh.3 uc002iei.4 uc002iej.3 uc010czi.2)
    ENST00000496503 ENST00000398389(uc010wik.2 uc010czj.2) ENST00000486600
    ENST00000466083 ENST00000475450 ENST00000479797 ENST00000589375 ENST00000480958

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MPP3:
    hsa-miR-203 hsa-miR-145* hsa-miR-9 hsa-miR-1263 hsa-miR-520d-5p hsa-miR-186 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidMPP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MPP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPP3
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    GenScript: all cDNA clones in your preferred vector: MPP3 (NM_001932)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPP3
    Sirion Biotech Customized lentivirus for stable overexpression of MPP3 
                         Customized lentivirus expression plasmids for stable overexpression of MPP3 
    Primer
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    OriGene qPCR primer pairs and template standards for MPP3
    OriGene qSTAR qPCR primer pairs in human, mouse for MPP3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPP3

    Additional mRNA sequence: 

    AK299535.1 AK309045.1 AK311368.1 AK313045.1 AM050144.1 AM050145.1 BC025743.1 BC035833.1 
    BC047017.1 BC056865.1 NR_003562.2 U37707.1 

    12 DOTS entries:

    DT.95364790  DT.101979630  DT.311724  DT.91664935  DT.40266796  DT.75150032  DT.40230225  DT.100829277 
    DT.99971581  DT.120907113  DT.311725  DT.97780778 

    24/52 AceView cDNA sequences (see all 52):

    AW955726 AW292372 BX094255 BE550837 AI049956 AI300965 NM_001932 BC035833 
    BM968956 BC047017 T27219 T27221 BF061922 BE669711 BC056865 BU634174 
    T27220 BU595516 W44684 AI654561 BU159483 BM906411 BI838192 AL709604 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MPP3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
    SP1:                    -                                         -                                         -                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                    -                                                                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 21
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for MPP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MPP3 expression in normal human tissues (normalized intensities)      MPP3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTGAAAGG
    MPP3 Expression
    About this image


    MPP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             ganglion/cranial/facial VII   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             autonomic/sympathetic/ganglion   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Kidney (Urinary System)
             Metanephros

    See MPP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MPP3

    SOURCE GeneReport for Unigene cluster: Hs.396566
        SABiosciences Custom PCR Arrays for MPP3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MPP3 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mpp31 , 5 membrane protein, palmitoylated 3 (MAGUK p55 subfamily more1, 5 87.29(n)1
    90.94(a)1
      11 (65.48 cM)5
    133841  NM_007863.21  NP_031889.21 
     1019996525 
    chicken
    (Gallus gallus)
    Aves MPP31 membrane protein, palmitoylated 3 (MAGUK p55 subfamily more 72.71(n)
    79.45(a)
      419985  XM_418108.3  XP_418108.3 
    lizard
    (Anolis carolinensis)
    Reptilia MPP36
    membrane protein, palmitoylated 3 (MAGUK p55 subfa...
    77(a)
    1 ↔ 1
    6(78192292-78264547)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5720791 MAGUK p55 subfamily member 3-like 67.01(n)
    71.13(a)
      572079  XM_695746.4  XP_700838.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta skf3 guanylate kinase 38(a)   47E1   --


    ENSEMBL Gene Tree for MPP3 (if available)
    TreeFam Gene Tree for MPP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MPP3 gene
    MPP62  MPP72  DLG32  MPP52  DLG22  MPP22  MPP42  DLG42  
    DLG12  CASK2  MPP12  
    11 SIMAP similar genes for MPP3 using alignment to 3 protein entries:     MPP3_HUMAN (see all proteins):
    MPP7    MPP4    DKFZp666F1010    MPP5    GUK1    MPP1
    DKFZp761P0818    MPP6    MPP2    DKFZp666D023    CASK

    MPP3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MPP3
    PGOHUM00000247999 PGOHUM00000246194


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/695 SNPs in MPP3 are shown (see all 695)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1139196361,2
    C,F--41877740(+) ACAAGA/CACACA 2 -- ds50012Minor allele frequency- C:0.25WA NA 122
    rs1479580871,2
    C--41877757(+) TGCCCA/GGCTAG 2 -- ds50010--------
    rs1489970051,2
    --41877947(+) ACTGTC/TTAAGC 2 -- ds50010--------
    rs717867211,2
    C--41878115(+) CACCTAAGA/-  
            
    TATAT
    2 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs169402161,2
    C,F--41878126(+) TATCAT/CGAATC 2 -- ds50017Minor allele frequency- C:0.12NA WA 264
    rs80778891,2
    C,F,H--41878166(+) AACCCA/CTTAGG 2 -- ds500116Minor allele frequency- C:0.17NS EA NA WA CSA 1866
    rs1909138161,2
    --41878386(+) GGCTCA/GATGTT 2 -- nc-transcript-variantut310--------
    rs1450600881,2
    --41878529(+) TTTACA/GTATAT 2 -- nc-transcript-variantut310--------
    rs1867411211,2
    --41878592(+) TCAAAA/GAAAAG 2 -- nc-transcript-variantut310--------
    rs739851101,2
    C--41878701(+) CGTCAC/TTATGT 2 -- nc-transcript-variantut312Minor allele frequency- T:0.21WA 120

    HapMap Linkage Disequilibrium report for MPP3 (41878167 - 41910547 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MPP3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv908265CNV Gain21882294
    nsv908267CNV Gain21882294


    Human Gene Mutation Database (HGMD): MPP3
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601114    OMIM disorders: --

    4 diseases for MPP3:    About MalaCards
    intellectual disability    pneumonia    tuberculosis    retinitis


    MPP3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MPP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 16282525 (1)


    Export disorders for MPP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MPP3 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with MPP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a gene (DLG3) encoding a second member of the discs- large family on chromosome 17q12-q21. (PubMed id 8824795)1, 2, 3 Smith S.A.... Albertsen H. (1996)
    2. Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg. (PubMed id 13679854)1, 2 Fukuhara H.... Murakami Y. (2003)
    3. MPP3 inactivation by promoter CpG islands hypermethyla tion in colorectal carcinogenesis. (PubMed id 23011156)1 Feng X....Zhou Y. (2012)
    4. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. [The growth inhibition effects of TSLC1 gene on human hepatocyte carcinoma cell line HepG2] (PubMed id 17669239)1 Qin L....Yang D.L. (2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane. (PubMed id 16519681)1 Kantardzhieva A....Wijnholds J. (2006)
    9. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    10. An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies. (PubMed id 15123239)1 Boisguerin P....Volkmer-Engert R. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4356 HGNC: 7221 AceView: MPP3 Ensembl:ENSG00000161647 euGenes: HUgn4356
    ECgene: MPP3 H-InvDB: MPP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MPP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MPP3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MPP3 gene:
    Search GeneIP for patents involving MPP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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