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Aliases for MPP2 Gene

Aliases for MPP2 Gene

  • Membrane Palmitoylated Protein 2 2 3
  • Membrane Protein, Palmitoylated 2 (MAGUK P55 Subfamily Member 2) 2 3
  • Membrane Protein, Palmitoylated 2 2 5
  • DLG2 3 4
  • MAGUK P55 Subfamily Member 2 2
  • Discs Large, Homolog 2 3
  • Discs Large Homolog 2 4
  • Protein MPP2 4
  • Discs Large 2
  • Homolog 2 2

External Ids for MPP2 Gene

Previous HGNC Symbols for MPP2 Gene

  • DLG2

Previous GeneCards Identifiers for MPP2 Gene

  • GC17M041694
  • GC17M044129
  • GC17M041963
  • GC17M042427
  • GC17M039308
  • GC17M037716
  • GC17M041952

Summaries for MPP2 Gene

Entrez Gene Summary for MPP2 Gene

  • Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. [provided by RefSeq, Jul 2008]

GeneCards Summary for MPP2 Gene

MPP2 (Membrane Palmitoylated Protein 2) is a Protein Coding gene. Diseases associated with MPP2 include danon disease. Among its related pathways are Hippo signaling pathway and Wnt signaling pathway (KEGG). GO annotations related to this gene include PDZ domain binding and guanylate kinase activity. An important paralog of this gene is MPP6.

Gene Wiki entry for MPP2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPP2 Gene

Genomics for MPP2 Gene

Regulatory Elements for MPP2 Gene

Genomic Location for MPP2 Gene

Chromosome:
17
Start:
43,875,357 bp from pter
End:
43,909,711 bp from pter
Size:
34,355 bases
Orientation:
Minus strand

Genomic View for MPP2 Gene

Genes around MPP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPP2 Gene

Proteins for MPP2 Gene

  • Protein details for MPP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14168-MPP2_HUMAN
    Recommended name:
    MAGUK p55 subfamily member 2
    Protein Accession:
    Q14168
    Secondary Accessions:
    • B4DGE9
    • B4DRJ0
    • B7Z3G8
    • E7EV80
    • E7EV91
    • E7EX01
    • Q53ES9
    • Q5CZB9
    • Q9BQJ2

    Protein attributes for MPP2 Gene

    Size:
    576 amino acids
    Molecular mass:
    64581 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MPP2 Gene

    Alternative splice isoforms for MPP2 Gene

neXtProt entry for MPP2 Gene

Proteomics data for MPP2 Gene at MOPED

Post-translational modifications for MPP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for MPP2 Gene

Domains & Families for MPP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q14168

UniProtKB/Swiss-Prot:

MPP2_HUMAN :
  • Contains 1 guanylate kinase-like domain.
  • Belongs to the MAGUK family.
Domain:
  • Contains 1 guanylate kinase-like domain.
  • Contains 2 L27 domains.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the MAGUK family.
genes like me logo Genes that share domains with MPP2: view

Function for MPP2 Gene

Molecular function for MPP2 Gene

GENATLAS Biochemistry:
membrane protein,palmitoylated 2,55kDa,involved in coupling the cytoskeleton to the cell membrane,tumor suppressor

Gene Ontology (GO) - Molecular Function for MPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with MPP2: view
genes like me logo Genes that share phenotypes with MPP2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPP2 Gene

Localization for MPP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MPP2 Gene COMPARTMENTS Subcellular localization image for MPP2 gene
Compartment Confidence
cytosol 4
plasma membrane 4
nucleus 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for MPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 7590743
genes like me logo Genes that share ontologies with MPP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MPP2 Gene

Pathways & Interactions for MPP2 Gene

genes like me logo Genes that share pathways with MPP2: view

Pathways by source for MPP2 Gene

1 BioSystems pathway for MPP2 Gene
1 KEGG pathway for MPP2 Gene

Gene Ontology (GO) - Biological Process for MPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 7590743
GO:0046710 GDP metabolic process TAS 7590743
genes like me logo Genes that share ontologies with MPP2: view

No data available for SIGNOR curated interactions for MPP2 Gene

Drugs & Compounds for MPP2 Gene

(2) Drugs for MPP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for MPP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MPP2: view

Transcripts for MPP2 Gene

Unigene Clusters for MPP2 Gene

Membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MPP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8: - - - - - -

ExUns: 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for MPP2 Gene

GeneLoc Exon Structure for
MPP2
ECgene alternative splicing isoforms for
MPP2

Expression for MPP2 Gene

mRNA expression in normal human tissues for MPP2 Gene

Protein differential expression in normal tissues from HIPED for MPP2 Gene

This gene is overexpressed in Retina (35.9), Brain (10.7), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPP2 Gene



SOURCE GeneReport for Unigene cluster for MPP2 Gene Hs.514208

genes like me logo Genes that share expression patterns with MPP2: view

Protein tissue co-expression partners for MPP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MPP2 Gene

Orthologs for MPP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MPP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MPP2 36
  • 98 (a)
OneToOne
MPP2 35
  • 98.99 (n)
  • 98.66 (a)
cow
(Bos Taurus)
Mammalia MPP2 36
  • 98 (a)
OneToOne
MPP2 35
  • 92.57 (n)
  • 98.01 (a)
dog
(Canis familiaris)
Mammalia MPP2 35
  • 91.18 (n)
  • 97.83 (a)
MPP2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mpp2 36
  • 97 (a)
OneToOne
Mpp2 16
Mpp2 35
  • 89.67 (n)
  • 97.64 (a)
oppossum
(Monodelphis domestica)
Mammalia MPP2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MPP2 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mpp2 35
  • 89.01 (n)
  • 98.01 (a)
chicken
(Gallus gallus)
Aves MPP2 35
  • 78.8 (n)
  • 85.05 (a)
MPP2 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MPP2 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mpp2 35
  • 69.8 (n)
  • 77.53 (a)
zebrafish
(Danio rerio)
Actinopterygii mpp2a 36
  • 63 (a)
OneToMany
mpp2b 36
  • 73 (a)
OneToMany
mpp2b 35
  • 70.64 (n)
  • 73.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9326 37
  • 38 (a)
skf 37
  • 39 (a)
vari 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y55B1BR.4 37
  • 27 (a)
Species with no ortholog for MPP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPP2 Gene

ENSEMBL:
Gene Tree for MPP2 (if available)
TreeFam:
Gene Tree for MPP2 (if available)

Paralogs for MPP2 Gene

Paralogs for MPP2 Gene

genes like me logo Genes that share paralogs with MPP2: view

Variants for MPP2 Gene

Sequence variations from dbSNP and Humsavar for MPP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs412849 -- 43,883,265(+) AGCCA(C/G)GTGCG reference, missense, utr-variant-5-prime
rs425135 -- 43,907,149(-) GGGGG(A/C/G/T)ACTTA intron-variant, upstream-variant-2KB
rs231488 -- 43,903,676(-) aagtt(C/G)tggct intron-variant
rs231489 -- 43,902,932(-) CATAT(A/G)CATCC intron-variant, upstream-variant-2KB
rs231493 -- 43,899,630(+) GGAAC(C/G)CTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPP2 Gene

Variant ID Type Subtype PubMed ID
nsv908265 CNV Gain 21882294
nsv908268 CNV Gain 21882294
esv2715959 CNV Deletion 23290073
esv26094 CNV Gain 19812545

Variation tolerance for MPP2 Gene

Residual Variation Intolerance Score: 13.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPP2 Gene

HapMap Linkage Disequilibrium report
MPP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPP2 Gene

Disorders for MPP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MPP2 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
danon disease
  • antopol disease
- elite association - COSMIC cancer census association via MalaCards
Search MPP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MPP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MPP2
genes like me logo Genes that share disorders with MPP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MPP2 Gene

Publications for MPP2 Gene

  1. A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dlg-A. (PMID: 7590743) Mazoyer S. … Ponder B.A.J. (Genomics 1995) 2 3 4 23 67
  2. The PDZ protein MPP2 interacts with c-Src in epithelial cells. (PMID: 19665017) Baumgartner M. … Moelling K. (Exp. Cell Res. 2009) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Heritability and genetic association analysis of cognition in theA Diabetes Heart Study. (PMID: 24684796) Cox A.J. … Bowden D.W. (Neurobiol. Aging 2014) 3

Products for MPP2 Gene

Sources for MPP2 Gene

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