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MPP2 Gene

protein-coding   GIFtS: 56
GCID: GC17M041952

Membrane Protein, Palmitoylated 2 (MAGUK P55 Subfamily Member...


(Previous symbol: DLG2)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane Protein, Palmitoylated 2 (MAGUK P55 Subfamily Member 2)1 2     Homolog 21
DLG21 2 3 5     Discs Large, Homolog 22
MAGUK P55 Subfamily Member 21 2     Discs Large Homolog 23
Discs Large1     Protein MPP23

External Ids:    HGNC: 72201   Entrez Gene: 43552   Ensembl: ENSG000001088527   OMIM: 6007235   UniProtKB: Q141683   

Export aliases for MPP2 gene to outside databases

Previous GC identifers: GC17M041694 GC17M044129 GC17M041963 GC17M042427 GC17M039308 GC17M037716


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MPP2 Gene:
Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs
(membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell
proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a
conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with
the cytoskeleton and are suspected to play important roles in signal transduction. (provided by RefSeq, Jul 2008)

GeneCards Summary for MPP2 Gene:
MPP2 (membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)) is a protein-coding gene. Diseases associated with MPP2 include danon disease, and vacuolar myopathy. GO annotations related to this gene include guanylate kinase activity. An important paralog of this gene is MPP7.

Gene Wiki entry for MPP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MPP2 gene promoter:
         RP58   p53   Pax-2a   Tal-1beta   E47   Egr-4   c-Ets-1   Pax-2b   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMPP2 promoter sequence
   Search Chromatin IP Primers for MPP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MPP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12-q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q12-q21

MPP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPP2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M041952:  view genomic region     (about GC identifiers)

Start:
41,952,725 bp from pter      End:
41,987,068 bp from pter
Size:
34,344 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MPP2_HUMAN, Q14168 (See protein sequence)
Recommended Name: MAGUK p55 subfamily member 2  
Size: 576 amino acids; 64581 Da
1 PDB 3D structure from and Proteopedia for MPP2:
2E7K (3D)    
Secondary accessions: Q53ES9 Q5CZB9 Q9BQJ2
Alternative splicing: 3 isoforms:  Q14168-1   Q14168-2   Q14168-3   

Explore the universe of human proteins at neXtProt for MPP2: NX_Q14168

Explore proteomics data for MPP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MPP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_001265299.1  NP_001265300.1  NP_001265301.1  NP_001265302.1  NP_001265303.1  NP_001265304.1  NP_001265305.2  NP_001265310.1  
    NP_005365.4  

    ENSEMBL proteins: 
     ENSP00000366389   ENSP00000269095   ENSP00000428286   ENSP00000428136   ENSP00000430540  
     ENSP00000428182   ENSP00000428468   ENSP00000428354   ENSP00000428218   ENSP00000430797  
     ENSP00000428938   ENSP00000430443   ENSP00000430349   ENSP00000429364   ENSP00000438012  

    MPP2 Human Recombinant Protein Products:

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    OriGene Purified Protein for MPP2
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    OriGene MassSpec for MPP2
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    Novus Biologicals MPP2 Proteins
    Novus Biologicals MPP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for MPP2

    MPP2 Antibody Products:

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    Abcam antibodies for MPP2
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    ThermoFisher Antibodies for MPP2
    LSBio Antibodies in human, mouse, rat for MPP2

    MPP2 Assay Products:

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    Cloud-Clone Corp. ELISAs for MPP2
    Cloud-Clone Corp. CLIAs for MPP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR008144 Guanylate_kin-like
     IPR008145 GK/Ca_channel_bsu
     IPR014775 L27_C
     IPR001452 SH3_domain
     IPR011511 SH3_2

    Graphical View of Domain Structure for InterPro Entry Q14168

    ProtoNet protein and cluster: Q14168

    5 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB001478 PDZ/DHR/GLGF domain
    IPB004172 L27 domain
    IPB008144 Guanylate kinase
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: MPP2_HUMAN, Q14168
    Similarity: Belongs to the MAGUK family
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 2 L27 domains
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 SH3 domain


    MPP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for MPP2:
    membrane protein,palmitoylated 2,55kDa,involved in coupling the cytoskeleton to the cell membrane,tumor suppressor

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004385guanylate kinase activity TAS7590743
    GO:0005515protein binding ----
    GO:0030165PDZ domain binding IEA--
         
    MPP2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MPP2:
     Increased cell death HMECs cel  Increased cell number in G1, a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MPP2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MPP2

    miRNA
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    miRTarBase miRNAs that target MPP2:
    hsa-mir-296-3p (MIRT038475), hsa-mir-128-3p (MIRT021960), hsa-mir-484 (MIRT042248), hsa-mir-1229-3p (MIRT036323), hsa-mir-155-5p (MIRT020593), hsa-mir-196a-5p (MIRT048275), hsa-mir-615-3p (MIRT040407), hsa-mir-30a-5p (MIRT028414)

    Block miRNA regulation of human, mouse, rat MPP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MPP2 (see all 36):
    hsa-miR-140-5p hsa-miR-1224-3p hsa-miR-128 hsa-miR-449a hsa-miR-1184 hsa-miR-3150b-3p hsa-miR-23a hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidMPP2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MPP2
    Predesigned siRNA for gene silencing in human, mouse, rat MPP2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for MPP2 (see all 6)
    OriGene ORF clones in mouse, rat for MPP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MPP2 (NM_005374)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPP2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MPP2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol3
    nucleus3
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS7590743
    GO:0016020membrane TAS7590743

    MPP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MPP2
    Interactions:

        Search GeneGlobe Interaction Network for MPP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for MPP2 (Q141682, 3 ENSP000002690954) via UniProtKB, MINT, STRING, and/or I2D (see all 577)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253440 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253440 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253440 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253440 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253440 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS7590743
    GO:0046939nucleotide phosphorylation TAS7590743

    MPP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MPP2

    7 Novoseek inferred chemical compound relationships for MPP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 33.9 1 18555174 (1)
    mannose 6-phosphate 31.9 1 10092649 (1)
    acridine 22.7 1 17416619 (1)
    glucose 18.2 5 17001002 (1), 11208137 (1), 8707843 (1), 9430681 (1) (see all 5)
    calcium 0 5 15846778 (1), 17204559 (1), 18809851 (1)
    glutamate 0 2 17416619 (1), 11517248 (1)
    cysteine 0 1 7911386 (1)



    MPP2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MPP2 gene (9 alternative transcripts): 
    NM_001278370.1  NM_001278371.1  NM_001278372.1  NM_001278373.1  NM_001278374.1  NM_001278375.1  NM_001278376.2  NM_001278381.1  
    NM_005374.4  

    Unigene Cluster for MPP2:

    Membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
    Hs.514208  [show with all ESTs]
    Unigene Representative Sequence: BC030287
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377184(uc002ien.1 uc010wim.1) ENST00000269095(uc002ieo.1 uc010win.1 uc010wio.1 uc010wip.1 uc010czm.1)
    ENST00000461854 ENST00000520305 ENST00000523501 ENST00000518766 ENST00000523220
    ENST00000473246 ENST00000520319 ENST00000520406 ENST00000523762 ENST00000523934
    ENST00000520241 ENST00000521178 ENST00000524294 ENST00000522172 ENST00000518478
    ENST00000536246
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat MPP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MPP2 (see all 36):
    hsa-miR-140-5p hsa-miR-1224-3p hsa-miR-128 hsa-miR-449a hsa-miR-1184 hsa-miR-3150b-3p hsa-miR-23a hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidMPP2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MPP2
    Predesigned siRNA for gene silencing in human, mouse, rat MPP2
    Clone
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    OriGene clones in human, mouse for MPP2 (see all 6)
    OriGene ORF clones in mouse, rat for MPP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MPP2 (NM_005374)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPP2
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    OriGene qPCR primer pairs and template standards for MPP2
    OriGene qSTAR qPCR primer pairs in human, mouse for MPP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MPP2
      QuantiTect SYBR Green Assays in human, mouse, rat MPP2
      QuantiFast Probe-based Assays in human, mouse, rat MPP2

    Additional mRNA sequence: 

    AK223560.1 AK294564.1 AK295858.1 AK299286.1 AK299321.1 AK299518.1 AK302793.1 AK309048.1 
    AK311166.1 AL136554.1 BC030287.1 CR936598.1 CR936730.1 

    12 DOTS entries:

    DT.411809  DT.97785653  DT.92422685  DT.100748226  DT.120923657  DT.120923664  DT.120923662  DT.95371816 
    DT.102839239  DT.120923646  DT.120923652  DT.120923653 

    Selected AceView cDNA sequences (see all 112):

    AA020831 CD620404 BU729575 AW134742 AI138231 AA917775 AI264850 CR612825 
    AI467911 AI693173 CD620405 T27218 BE301426 AA890332 AL711773 CD620399 
    BQ719307 AA580963 X82895 BQ896170 AI263681 BV198775 AW514227 BF338695 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MPP2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
    SP1:                                -           -     -                                   -                                                                     
    SP2:                                -           -     -                 -                 -                                                                     
    SP3:                                                                    -                 -                                                                     
    SP4:                                -           -     -           -     -                 -                                                                     
    SP5:                                                  -                 -                 -                                                                     

    ExUns: 17
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for MPP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MPP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACCTTCAC
    MPP2 Expression
    About this image

    MPP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MPP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514208
        Custom PCR Arrays for MPP2
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    QuantiFast Probe-based Assays in human, mouse, rat MPP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MPP2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mpp21 , 5 membrane protein, palmitoylated 2 (MAGUK p55 subfamily more1, 5 89.67(n)1
    97.64(a)1
      11 (65.48 cM)5
    509971  NM_016695.31  NP_057904.11 
     1020570155 
    chicken
    (Gallus gallus)
    Aves MPP21 membrane protein, palmitoylated 2 (MAGUK p55 subfamily more 78.8(n)
    85.05(a)
      420006  XM_003642818.2  XP_003642866.2 
    lizard
    (Anolis carolinensis)
    Reptilia MPP26
    membrane protein, palmitoylated 2 (MAGUK p55 subfa...
    78(a)
    1 ↔ 1
    6(77760869-77823669)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mpp21 membrane protein, palmitoylated 2 (MAGUK p55 subfamily more 69.8(n)
    77.53(a)
      100124723  NM_001102706.1  NP_001096176.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mpp2b1 membrane protein, palmitoylated 2b (MAGUK p55 subfamily more 70.64(n)
    73.94(a)
      431770  NM_001002223.1  NP_001002223.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta skf3 guanylate kinase 39(a)
    (best of 2)
      47E1   --


    ENSEMBL Gene Tree for MPP2 (if available)
    TreeFam Gene Tree for MPP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MPP2 gene
    MPP72  DLG32  MPP62  MPP52  DLG22  MPP42  DLG42  DLG12  
    CASK2  MPP12  MPP32  
    12 SIMAP similar genes for MPP2 using alignment to 14 protein entries:     MPP2_HUMAN (see all proteins):
    MPP6    DKFZp666F1010    MPP1    MPP5    CASK    MPP7
    GUK1    DKFZp666D023    DLG2    MPP3    DKFZp761P0818    MPP4

    MPP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MPP2 (see all 790)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1866585051,2
    --41952304(+) GCTGAA/GCTAAT 1 -- ds50010--------
    rs1910537451,2
    --41952313(+) ATGTAC/TGTTCC 1 -- ds50010--------
    rs1837710801,2
    --41952412(+) TGAGAC/TGGTAA 1 -- ds50010--------
    rs1486872321,2
    --41952460(+) GTGACA/GTAAAG 1 -- ds50010--------
    rs285646341,2
    C,F--41952551(+) AGCATC/TTTCTG 1 -- ds50012Minor allele frequency- T:0.16WA 120
    rs25371,2
    C,F,H--41952807(+) GGGAGG/AGAACA 1 -- ut31 ese3 trp312Minor allele frequency- A:0.04MN NA NS 1218
    rs773198521,2
    C--41952816(+) CAGAGG/AAAGCG 1 -- ut312Minor allele frequency- A:0.07CSA WA 120
    rs1506514601,2
    C--41952932(+) AGAGC-/TAATGTGG 1 -- cds10--------
    rs1396906241,2
    C--41953007(+) TCTGC-/TCCC  
      ACCTGA
    TAGGT
    1 -- ut310--------
    rs99010611,2
    C,A,H--41953034(+) GAGTGA/GGGGCT 1 -- ut31 ese36Minor allele frequency- G:0.02NS EA CSA WA 535

    HapMap Linkage Disequilibrium report for MPP2 (41952725 - 41987068 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MPP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715959CNV Deletion23290073
    esv26094CNV Gain19812545
    nsv908265CNV Gain21882294
    nsv908268CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MPP2
    DNA2.0 Custom Variant and Variant Library Synthesis for MPP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600723    OMIM disorders: --

    Selected diseases for MPP2 (see all 25):    
    About MalaCards
    danon disease    vacuolar myopathy    tetanus    ehrlichiosis
    reactive arthritis    glycogen storage disease    tremor    hypertrophic cardiomyopathy
    myopathy    dilated cardiomyopathy    choroiditis    glomerulonephritis
    mental retardation    periodontitis    influenza    pneumonia
    neuroblastoma    pancreatitis    schizophrenia    pancreatic cancer


    MPP2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    7 Novoseek inferred disease relationships for MPP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    danon disease 96.5 17 16565504 (2), 16372318 (1), 18555174 (1), 18377432 (1) (see all 16)
    myopathy 63.6 8 16372318 (1), 16565504 (1), 18555174 (1), 18004770 (1) (see all 7)
    tetanus 60.4 4 10886393 (1), 18543947 (1), 18369946 (1), 11020378 (1)
    glycogen storage disease 57.4 1 18555174 (1)
    mental retardation 50.3 4 16372318 (1), 16565504 (1), 18004770 (1), 16217705 (1)
    cardiomyopathy 43.2 3 16372318 (1), 15889279 (1), 16217705 (1)
    tumors 2.87 3 7590743 (2), 10554036 (1)


    Export disorders for MPP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MPP2 gene, integrated from 10 sources (see all 136):
    (articles sorted by number of sources associating them with MPP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dlg-A. (PubMed id 7590743)1, 2, 3, 9 Mazoyer S.... Ponder B.A.J. (Genomics 1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    4. The PDZ protein MPP2 interacts with c-Src in epithelial cells. (PubMed id 19665017)1, 9 Baumgartner M....Moelling K. (Exp. Cell Res. 2009)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    9. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4355 HGNC: 7220 AceView: MPP2 Ensembl:ENSG00000108852 euGenes: HUgn4355
    ECgene: MPP2 H-InvDB: MPP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MPP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MPP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MPP2 gene:
    Search GeneIP for patents involving MPP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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