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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MPP2 Gene

protein-coding   GIFtS: 56
GCID: GC17M041963

membrane protein, palmitoylated 2 (MAGUK p55 subfamily member...


(Previous symbol: DLG2)
 Explore 29 diseases affiliated with
MPP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MPP2    

Aliases
for MPP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Membrane Protein, Palmitoylated 2 (MAGUK P55 Subfamily Member 2)1 2     Discs Large, Homolog 22
DLG21 2 3 5     MAGUK P55 Subfamily Member 22
Discs Large Homolog 22 3     Protein MPP23
DKFZp761D07121     

External Ids:    HGNC: 72201   Entrez Gene: 43552   Ensembl: ENSG000001088527   OMIM: 6007235   UniProtKB: Q141683   

Export aliases for MPP2 gene to outside databases

Previous GC identifers: GC17M041694 GC17M044129 GC17M042427 GC17M039308 GC17M037716


Summaries
for MPP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MPP2:
Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs
(membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell
proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved
sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton
and are suspected to play important roles in signal transduction. (provided by RefSeq, Jul 2008)

Gene Wiki entry for MPP2


Genomic Views
for MPP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MPP2 gene promoter:
         RP58   p53   Pax-2a   Tal-1beta   E47   Egr-4   c-Ets-1   Pax-2b   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MPP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MPP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12-q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q12-q21

MPP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPP2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M041963:  view genomic region     (about GC identifiers)

Start:
 41,952,725 bp from pter      End:
 41,987,068 bp from pter
Size:
 34,344 bases      Orientation:
 minus strand

Proteins
for MPP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MPP2_HUMAN, Q14168 (See protein sequence)
Recommended Name: MAGUK p55 subfamily member 2  
Size: 576 amino acids; 64581 Da
1 PDB 3D structure from and Proteopedia for MPP2:
2E7K (3D)    
Secondary accessions: Q53ES9 Q5CZB9 Q9BQJ2
Alternative splicing: 3 isoforms:  Q14168-1   Q14168-2   Q14168-3   

Explore the universe of human proteins at neXtProt for MPP2: NX_Q14168

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14168

    • MPP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005365.3  
    ENSEMBL proteins: 
     ENSP00000366389   ENSP00000269095   ENSP00000428286   ENSP00000428136   ENSP00000430540  
     ENSP00000428182   ENSP00000428468   ENSP00000428354   ENSP00000428218   ENSP00000430797  
     ENSP00000428938   ENSP00000430443   ENSP00000430349   ENSP00000429364   ENSP00000438012  

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    Novus Biologicals MPP2 Proteins
    Novus Biologicals MPP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MPP2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005887integral to plasma membrane TAS7590743
    GO:0009986cell surface IDA12493773
    GO:0016020membrane TAS7590743


    MPP2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MPP2

    Protein Domains /
    Families
    for MPP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MPP2 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR008144 Guanylate_kin
     IPR008145 Guanylate_kin/L-typ_Ca_channel
     IPR014775 L27_C
     IPR001452 SH3_domain
     IPR011511 SH3_2

    Graphical View of Domain Structure for InterPro Entry Q14168

    ProtoNet protein and cluster: Q14168

    5 Blocks protein families:
    IPB001452 SH3 domain signature
    IPB001478 PDZ/DHR/GLGF domain
    IPB004172 L27 domain
    IPB008144 Guanylate kinase
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: MPP2_HUMAN, Q14168
    Similarity: Belongs to the MAGUK family
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 2 L27 domains
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 SH3 domain


    Function
    for MPP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for MPP2:
    membrane protein,palmitoylated 2,55kDa,involved in coupling the cytoskeleton to the cell membrane,tumor suppressor

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPP2
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate MPP2 (see all 36):
    hsa-miR-140-5p hsa-miR-1224-3p hsa-miR-128 hsa-miR-449a hsa-miR-1184 hsa-miR-3150b-3p hsa-miR-23a hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MPP2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPP2 (see all 4)
    OriGene shRNA RFP: MPP2
    OriGene siRNA: MPP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPP2

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPP2 

    Cell Line
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    Search LifeMap BioReagents cell lines for MPP2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004385guanylate kinase activity TAS7590743


    MPP2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MPP2:
     Increased cell death HMECs cel  Increased cell number in G1, a 


    Pathways & Interactions
    for MPP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MPP2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/540 Interacting proteins for MPP2 (Q141682, 3 ENSP000002690954) via UniProtKB, MINT, STRING, and/or I2D (see all 540)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLK1P533502, 3MINT-8266931 MINT-7947479 I2D: score=2 
    CSNK2BP678702, 3MINT-8253440 I2D: score=2 
    DLG1Q129593, ENSP000003457314I2D: score=2 STRING: ENSP00000345731
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    AXIN2Q9Y2T13I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8824795


    MPP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MPP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MPP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MPP2
    7 Novoseek chemical compound relationships for MPP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 33.9 1 18555174 (1)
    mannose 6-phosphate 31.9 1 10092649 (1)
    acridine 22.7 1 17416619 (1)
    glucose 18.2 5 17001002 (1), 11208137 (1), 8707843 (1), 9430681 (1) (see all 5)
    calcium 0 5 15846778 (1), 17204559 (1), 18809851 (1)
    glutamate 0 2 17416619 (1), 11517248 (1)
    cysteine 0 1 7911386 (1)

    Search CenterWatch for drugs/clinical trials and news about MPP2 

    Transcripts
    for MPP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MPP2 gene: 
    NM_005374.3  

    Unigene Cluster for MPP2:

    Membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
    Hs.514208  [show with all ESTs]
    Unigene Representative Sequence: BC030287
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377184(uc002ien.1 uc010wim.1) ENST00000269095(uc002ieo.1 uc010win.1 uc010wio.1 uc010wip.1 uc010czm.1)
    ENST00000461854 ENST00000520305 ENST00000523501 ENST00000518766 ENST00000523220
    ENST00000473246 ENST00000520319 ENST00000520406 ENST00000523762 ENST00000523934
    ENST00000520241 ENST00000521178 ENST00000524294 ENST00000522172 ENST00000518478
    ENST00000536246

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MPP2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPP2
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate MPP2 (see all 36):
    hsa-miR-140-5p hsa-miR-1224-3p hsa-miR-128 hsa-miR-449a hsa-miR-1184 hsa-miR-3150b-3p hsa-miR-23a hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MPP2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPP2 (see all 4)
    OriGene shRNA RFP: MPP2
    OriGene siRNA: MPP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPP2
    Clone
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    GenScript: all cDNA clones in your preferred vector: MPP2 (NM_005374)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPP2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPP2

    Additional cDNA sequence: 

    AK223560.1 AK294564.1 AK295858.1 AK299286.1 AK299321.1 AK299518.1 AK302793.1 AK309048.1 
    AK311166.1 AL136554.1 BC030287.1 CR936598.1 CR936730.1 

    12 DOTS entries:

    DT.411809  DT.97785653  DT.92422685  DT.100748226  DT.120923657  DT.120923664  DT.120923662  DT.95371816 
    DT.102839239  DT.120923646  DT.120923652  DT.120923653 

    24/112 AceView cDNA sequences (see all 112):

    CD620404 BU729575 AA917775 CD620405 AA890332 AW134742 AI138231 AI467911 
    AI264850 BE301426 AI693173 CR612825 T27218 AA020831 BP360770 BX327975 
    BU552672 BV198775 AI038007 CB118166 AL136554 BX280739 BC030287 AW514227 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MPP2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
    SP1:                                -           -     -                                   -                                                                     
    SP2:                                -           -     -                 -                 -                                                                     
    SP3:                                                                    -                 -                                                                     
    SP4:                                -           -     -           -     -                 -                                                                     
    SP5:                                                  -                 -                 -                                                                     

    ExUns: 17
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for MPP2

    Expression
    for MPP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MPP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCACCTTCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MPP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MPP2

    SOURCE GeneReport for Unigene cluster: Hs.514208
        SABiosciences Custom PCR Arrays for MPP2
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP2

    Orthologs
    for MPP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for MPP2 gene from 8/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MPP21 membrane protein, palmitoylated 2 (MAGUK p55 subfamily more 79.7(n)
    86.35(a)    		   420006  XM_003642818.1  XP_003642866.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MPP26
    --
    (see all 3)    		 --
    		 84(a)
    23(a)
    (see all 3)    		 1 ↔ 1
    possible ortholog
    (see all 3)    		 6(77760869-77787357)
    GL344565.1(6101-23422)
    zebrafish
    (Danio rerio)    		 Actinopterygii mpp2b1 membrane protein, palmitoylated 2b (MAGUK p55 subfamily more 70.64(n)
    73.76(a)    		   431770  NM_001002223.1  NP_001002223.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta skf3 guanylate kinase 39(a)
    (best of 2)    		   47E1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y55B1BR.43   -- 27(a)   III(464865-471694)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G062006
    GK-16
    (see all 3)    		 guanylate kinase 1
    (see all 3)    		 16(a)
    15(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 3(1877594-1879348)
    2(17474619-17477223)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 guanylate kinase, putative, expressed
    		 16(a)
    14(a)
    		 possible ortholog
    possible ortholog
    		 3(11594171-11597778)
    12(20000190-20004313)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria gmk6
    		 guanylate kinase
    		 22(a)
    		 possible ortholog
    		 Chromosome(3819451-3820074)


    ENSEMBL Gene Tree for MPP2 (if available)
    TreeFam Gene Tree for MPP2 (if available) 

    Paralogs
    for MPP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MPP2 gene
    MPP62  MPP72  DLG32  MPP52  DLG22  MPP42  DLG42  DLG12  
    CASK2  MPP12  MPP32  
    12 SIMAP similar genes for MPP2 using alignment to 14 protein entries:     MPP2_HUMAN (see all proteins):
    MPP6    DKFZp666F1010    MPP1    MPP5    MPP7    CASK
    GUK1    DKFZp666D023    DLG2    MPP3    DKFZp761P0818    MPP4

    MPP2 for paralogs           About GeneDecksing



    Genomic Variants
    for MPP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/642 NCBI SNPs in MPP2 are shown (see all 642)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1866585051,2
    		--41952304(+) GCTGAA/GCTAAT 1 -- ds50010--------
    rs1910537451,2
    		--41952313(+) ATGTAC/TGTTCC 1 -- ds50010--------
    rs1837710801,2
    		--41952412(+) TGAGAC/TGGTAA 1 -- ds50010--------
    rs1486872321,2
    		--41952460(+) GTGACA/GTAAAG 1 -- ds50010--------
    rs285646341,2
    		C,--41952551(+) AGCATC/TTTCTG 1 -- ds50012Minor allele frequency- T:0.16WA 120
    rs25371,2
    		C,F,H,--41952807(+) GGGAGG/AGAACA 1 -- ut31 ese3 trp312Minor allele frequency- A:0.04MN NA NS 1218
    rs773198521,2
    		C,--41952816(+) CAGAGG/AAAGCG 1 -- ut312Minor allele frequency- A:0.07CSA WA 120
    rs1506514601,2
    		C,--41952932(+) AGAGC-/TAATGTGG 1 -- ut310--------
    rs1396906241,2
    		C,--41953007(+) TCTGC-/TCCC  
      ACCTGA    TAGGT     		1 -- ut310--------
    rs99010611,2
    		C,A,H,--41953034(+) GAGTGA/GGGGCT 1 -- ut31 ese36Minor allele frequency- G:0.02NS EA CSA WA 535

    HapMap Linkage Disequilibrium report for MPP2 (41952725 - 41987068 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MPP2
         1 Indel: 72940

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    Disorders / Diseases
    for MPP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MPP2 for disorders           About GeneDecksing

    OMIM gene information: 600723    OMIM disorders: --

    20/29 diseases for MPP2 (see all 29):    About MalaCards
    glycogen storage disease    danon disease    vacuolar myopathy    bipolar affective disorder
    reactive arthritis    hypertrophic cardiomyopathy    ehrlichiosis    dilated cardiomyopathy
    tetanus    cardiomyopathy    myopathy    tremor
    choroiditis    neurodegeneration    arthritis    periodontitis
    influenza    pancreatic cancer    pancreatitis    pneumonia

    7 Novoseek disease relationships for MPP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    danon disease 96.5 17 16565504 (2), 16372318 (1), 18555174 (1), 18377432 (1) (see all 16)
    myopathy 63.6 8 16372318 (1), 16565504 (1), 18555174 (1), 18004770 (1) (see all 7)
    tetanus 60.4 4 10886393 (1), 18543947 (1), 18369946 (1), 11020378 (1)
    glycogen storage disease 57.4 1 18555174 (1)
    mental retardation 50.3 4 16372318 (1), 16565504 (1), 18004770 (1), 16217705 (1)
    cardiomyopathy 43.2 3 16372318 (1), 15889279 (1), 16217705 (1)
    tumors 2.87 3 7590743 (2), 10554036 (1)


    Export disorders for MPP2 gene to outside databases

    Publications
    for MPP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MPP2 gene, integrated from 9 sources (see all 132):
    (articles sorted by number of sources associating them with MPP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dlg-A. (PubMed id 7590743)1, 2, 3, 9 Mazoyer S.... Ponder B.A.J. (1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    4. The PDZ protein MPP2 interacts with c-Src in epitheli al cells. (PubMed id 19665017)1, 9 Baumgartner M....Moelling K. (2009)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    10. Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPalpha. (PubMed id 18239623)1 Bararia D....Behre G. (2008)

    External Searches for MPP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing MPP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4355 HGNC: 7220 AceView: MPP2 Ensembl:ENSG00000108852 euGenes: HUgn4355
    ECgene: MPP2 H-InvDB: MPP2

    Other Databases showing MPP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MPP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MPP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MPP2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MPP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MPP2 gene:
    Search GeneIP for patents involving MPP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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