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Aliases for MPP2 Gene

Aliases for MPP2 Gene

  • Membrane Protein, Palmitoylated 2 (MAGUK P55 Subfamily Member 2) 2 3
  • DLG2 3 4 6
  • MAGUK P55 Subfamily Member 2 2 3
  • Discs Large, Homolog 2 3
  • Discs Large Homolog 2 4
  • Protein MPP2 4
  • Discs Large 2
  • Homolog 2 2

External Ids for MPP2 Gene

Previous HGNC Symbols for MPP2 Gene

  • DLG2

Previous GeneCards Identifiers for MPP2 Gene

  • GC17M041694
  • GC17M044129
  • GC17M041963
  • GC17M042427
  • GC17M039308
  • GC17M037716
  • GC17M041952

Summaries for MPP2 Gene

Entrez Gene Summary for MPP2 Gene

  • Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. [provided by RefSeq, Jul 2008]

GeneCards Summary for MPP2 Gene

MPP2 (Membrane Protein, Palmitoylated 2 (MAGUK P55 Subfamily Member 2)) is a Protein Coding gene. Diseases associated with MPP2 include danon disease and vacuolar myopathy. Among its related pathways are Hippo signaling pathway and Wnt signaling pathway (KEGG). GO annotations related to this gene include guanylate kinase activity. An important paralog of this gene is MPP6.

Gene Wiki entry for MPP2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPP2 Gene

Genomics for MPP2 Gene

Regulatory Elements for MPP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MPP2 Gene

43,875,357 bp from pter
43,909,711 bp from pter
34,355 bases
Minus strand

Genomic View for MPP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPP2 Gene

Proteins for MPP2 Gene

  • Protein details for MPP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MAGUK p55 subfamily member 2
    Protein Accession:
    Secondary Accessions:
    • B4DGE9
    • B4DRJ0
    • B7Z3G8
    • E7EV80
    • E7EV91
    • E7EX01
    • Q53ES9
    • Q5CZB9
    • Q9BQJ2

    Protein attributes for MPP2 Gene

    576 amino acids
    Molecular mass:
    64581 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MPP2 Gene

    Alternative splice isoforms for MPP2 Gene

neXtProt entry for MPP2 Gene

Proteomics data for MPP2 Gene at MOPED

Post-translational modifications for MPP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for MPP2 Gene

Domains for MPP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q14168
  • Contains 1 guanylate kinase-like domain.
  • Contains 2 L27 domains.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 SH3 domain.
  • Belongs to the MAGUK family.
genes like me logo Genes that share domains with MPP2: view

No data available for Gene Families for MPP2 Gene

Function for MPP2 Gene

Molecular function for MPP2 Gene

GENATLAS Biochemistry:
membrane protein,palmitoylated 2,55kDa,involved in coupling the cytoskeleton to the cell membrane,tumor suppressor

Gene Ontology (GO) - Molecular Function for MPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004385 guanylate kinase activity TAS 7590743
GO:0005515 protein binding IPI 25416956
GO:0030165 PDZ domain binding IEA --
genes like me logo Genes that share ontologies with MPP2: view

Phenotypes for MPP2 Gene

GenomeRNAi human phenotypes for MPP2:
genes like me logo Genes that share phenotypes with MPP2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MPP2 Gene

Localization for MPP2 Gene

Subcellular locations from

Jensen Localization Image for MPP2 Gene COMPARTMENTS Subcellular localization image for MPP2 gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 7590743
GO:0016020 membrane TAS 7590743
genes like me logo Genes that share ontologies with MPP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MPP2 Gene

Pathways for MPP2 Gene

genes like me logo Genes that share pathways with MPP2: view

Pathways by source for MPP2 Gene

1 Cell Signaling Technology pathway for MPP2 Gene
1 BioSystems pathway for MPP2 Gene
1 KEGG pathway for MPP2 Gene

Gene Ontology (GO) - Biological Process for MPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 7590743
GO:0046939 nucleotide phosphorylation TAS 7590743
genes like me logo Genes that share ontologies with MPP2: view

Compounds for MPP2 Gene

(7) Novoseek inferred chemical compound relationships for MPP2 Gene

Compound -log(P) Hits PubMed IDs
glycogen 33.9 1
mannose 6-phosphate 31.9 1
acridine 22.7 1
glucose 18.2 5
calcium 0 3
genes like me logo Genes that share compounds with MPP2: view

Transcripts for MPP2 Gene

Unigene Clusters for MPP2 Gene

Membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8: - - - - - -

ExUns: 17

Relevant External Links for MPP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPP2 Gene

mRNA expression in normal human tissues for MPP2 Gene

Protein differential expression in normal tissues for MPP2 Gene

This gene is overexpressed in Retina (35.9), Brain (10.7), and Fetal Brain (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPP2 Gene

SOURCE GeneReport for Unigene cluster for MPP2 Gene Hs.514208

genes like me logo Genes that share expressions with MPP2: view

Expression partners for MPP2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MPP2 Gene

Orthologs for MPP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MPP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MPP2 35
  • 92.57 (n)
  • 98.01 (a)
MPP2 36
  • 98 (a)
(Canis familiaris)
Mammalia MPP2 35
  • 91.18 (n)
  • 97.83 (a)
MPP2 36
  • 94 (a)
(Mus musculus)
Mammalia Mpp2 35
  • 89.67 (n)
  • 97.64 (a)
Mpp2 16
Mpp2 36
  • 97 (a)
(Pan troglodytes)
Mammalia MPP2 35
  • 98.99 (n)
  • 98.66 (a)
MPP2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Mpp2 35
  • 89.01 (n)
  • 98.01 (a)
(Monodelphis domestica)
Mammalia MPP2 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia MPP2 36
  • 87 (a)
(Gallus gallus)
Aves MPP2 35
  • 78.8 (n)
  • 85.05 (a)
MPP2 36
  • 83 (a)
(Anolis carolinensis)
Reptilia MPP2 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mpp2 35
  • 69.8 (n)
  • 77.53 (a)
(Danio rerio)
Actinopterygii mpp2b 35
  • 70.64 (n)
  • 73.94 (a)
mpp2a 36
  • 63 (a)
mpp2b 36
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9326 37
  • 38 (a)
skf 37
  • 39 (a)
vari 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea Y55B1BR.4 37
  • 27 (a)
Species with no ortholog for MPP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPP2 Gene

Gene Tree for MPP2 (if available)
Gene Tree for MPP2 (if available)

Paralogs for MPP2 Gene

Paralogs for MPP2 Gene

genes like me logo Genes that share paralogs with MPP2: view

Variants for MPP2 Gene

Sequence variations from dbSNP and Humsavar for MPP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2537 -- 43,875,439(+) GGGAG(A/G)GAACA utr-variant-3-prime
rs105025 -- 43,910,073(-) ATTGC(C/T)GACCT upstream-variant-2KB
rs124719 -- 43,882,975(-) CCTAC(A/G)TTCAG reference, synonymous-codon, utr-variant-5-prime
rs143378842 -- 43,878,323(+) CCAGT(C/T)AGTGG intron-variant
rs143370569 -- 43,897,873(+) ATTTT(A/C)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPP2 Gene

Variant ID Type Subtype PubMed ID
nsv908265 CNV Gain 21882294
nsv908268 CNV Gain 21882294
esv2715959 CNV Deletion 23290073
esv26094 CNV Gain 19812545

Relevant External Links for MPP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPP2 Gene

Disorders for MPP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MPP2 Gene in MalaCards »

(2) Diseases for MPP2 Gene including...

(7) Novoseek inferred disease relationships for MPP2 Gene

Disease -log(P) Hits PubMed IDs
danon disease 96.5 17
myopathy 63.6 7
tetanus 60.4 4
glycogen storage disease 57.4 1
mental retardation 50.3 4
genes like me logo Genes that share disorders with MPP2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for MPP2 Gene

Publications for MPP2 Gene

  1. A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dlg-A. (PMID: 7590743) Mazoyer S. … Ponder B.A.J. (Genomics 1995) 2 3 4 23
  2. The PDZ protein MPP2 interacts with c-Src in epithelial cells. (PMID: 19665017) Baumgartner M. … Moelling K. (Exp. Cell Res. 2009) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. Identification of multiple binding partners for the amino-terminal domain of synapse-associated protein 97. (PMID: 12351654) Karnak D. … Margolis B. (J. Biol. Chem. 2002) 3

Products for MPP2 Gene

  • Addgene plasmids for MPP2

Sources for MPP2 Gene

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