Aliases for MPP1 Gene
External Ids for MPP1 Gene
Previous HGNC Symbols for MPP1 Gene
Previous GeneCards Identifiers for MPP1 Gene
This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
GeneCards Summary for MPP1 Gene
MPP1 (Membrane Palmitoylated Protein 1) is a Protein Coding gene. Diseases associated with MPP1 include nasopharyngeal carcinoma. GO annotations related to this gene include guanylate kinase activity. An important paralog of this gene is MPP6.
UniProtKB/Swiss-Prot for MPP1 Gene
Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity).