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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MPP1 Gene

protein-coding   GIFtS: 59
GCID: GC0XM154006

membrane protein, palmitoylated 1, 55kDa

(Previous names: membrane protein, palmitoylated 1 (55kD) )
(Previous symbol: DXS552E)
 Explore 33 diseases affiliated with
MPP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MPP1    

Aliases
for MPP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Membrane Protein, Palmitoylated 1, 55kDa1 2     MRG12
DXS552E1 2 3     Aging-Associated Gene 122
PEMP1 2 5     Erythrocyte Membrane Protein P552
EMP552 3 5     Migration-Related Gene 12
P551     Palmitoylated Erythrocyte Membrane Protein2
Membrane Protein, Palmitoylated 1 (55kD)1     Membrane Protein, Palmitoylated 13
55 KDa Erythrocyte Membrane Protein2     EC 2.7.118
AAG122     

External Ids:    HGNC: 72191   Entrez Gene: 43542   Ensembl: ENSG000001308307   OMIM: 3053605   UniProtKB: Q000133   

Export aliases for MPP1 gene to outside databases

Previous GC identifers: GC0XM148070 GC0XM150387 GC0XM151592 GC0XM152474 GC0XM153570 GC0XM153660 GC0XM142550


Summaries
for MPP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MPP1:
This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact
with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded
protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif,
and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional
proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell
development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid
cells. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,
Oct 2009)

UniProtKB/Swiss-Prot: EM55_HUMAN, Q00013
Function: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1
phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity)

Gene Wiki entry for MPP1


Genomic Views
for MPP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MPP1 gene promoter:
         GATA-3   FOXF2   FOXD3   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   HNF-3beta   GATA-2   GATA-1   NF-kappaB1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MPP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MPP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

MPP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPP1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM154006:  view genomic region     (about GC identifiers)

Start:
 154,006,959 bp from pter      End:
 154,049,282 bp from pter
Size:
 42,324 bases      Orientation:
 minus strand

Proteins
for MPP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: EM55_HUMAN, Q00013 (See protein sequence)
Recommended Name: 55 kDa erythrocyte membrane protein  
Size: 466 amino acids; 52296 Da
Subunit: Heterodimer with MPP5. Interacts with DLG5 and NF2. Interacts (via guanylate kinase-like domain) with WHRN
(via third PDZ domain)
Subcellular location: Membrane; Lipid-anchor. Cell projection, stereocilium (By similarity). Note=Colocalizes with WHRN
at stereocilium tip during hair cell development (By similarity). Colocalizes with MPP5 in the retina, at the outer
limiting membrane (OLM). Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm
layer (OPL), basal bodies and at the connecting cilium (CC). Colocalizes with NF2 in non-myelin-forming Schwann cells
3 PDB 3D structures from and Proteopedia for MPP1:
2EJY (3D)        2EV8 (3D)        3NEY (3D)    
Secondary accessions: B4DZV5 G3XAI1 Q2TSB6 Q5J7V5
Alternative splicing: 3 isoforms:  Q00013-1   Q00013-2   Q00013-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MPP1: NX_Q00013

Post-translational modifications:

  • Extensively palmitoylated by ZDHHC17, palmitoylation is essential for membrane organization and is crucial for proper
    • erythrocytes morphology1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q00013

    • 2 DME Specific Peptides for MPP1 (Q00013)
     PQWVPVSW  AGLIPSPELQEWR 

    MPP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001159932.1  NP_001159933.1  NP_001159934.1  NP_002427.1  

    ENSEMBL proteins: 
     ENSP00000358547   ENSP00000400700   ENSP00000377165   ENSP00000410888   ENSP00000377163  
     ENSP00000391701   ENSP00000389321   ENSP00000358544   ENSP00000400155  

    Human Recombinant Protein Products: 
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    Novus Biologicals MPP1 Proteins
    Novus Biologicals MPP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MPP1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005624membrane fraction ----
    GO:0005887integral to plasma membrane TAS1713685
    GO:0016020membrane TAS1713685
    GO:0030863cortical cytoskeleton IEA--


    MPP1 for ontologies           About GeneDecksing



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    ThermoFisher Antibody for MPP1

    Assay Products for MPP1: 
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    Uscn ELISAs and CLIAs for MPP1

    Protein Domains /
    Families
    for MPP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MPP1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR008144 Guanylate_kin
     IPR008145 Guanylate_kin/L-typ_Ca_channel
     IPR001452 SH3_domain
     IPR011511 SH3_2
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q00013

    ProtoNet protein and cluster: Q00013

    4 Blocks protein families:
    IPB001452 SH3 domain signature
    IPB001478 PDZ/DHR/GLGF domain
    IPB008144 Guanylate kinase
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: EM55_HUMAN, Q00013
    Similarity: Belongs to the MAGUK family
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 SH3 domain


    Function
    for MPP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: EM55_HUMAN, Q00013
    Function: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1
    phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity)

         Genatlas biochemistry entry for MPP1:
    erythrocyte surface protein,palmitoylated,55kDa,involved in coupling the cytoskeleton to the cell membrane (protein
    4.1)

    Enzyme Number (IUBMB): EC 2.7.112

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPP1
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate MPP1 (see all 14):
    hsa-miR-3678-3p hsa-miR-3140-3p hsa-miR-137 hsa-miR-92a hsa-miR-2278 hsa-miR-367 hsa-miR-25 hsa-miR-1271
    SwitchGear 3'UTR luciferase reporter plasmid: MPP1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPP1 (see all 4)
    OriGene shRNA RFP: MPP1
    OriGene siRNA: MPP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPP1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MPP1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPP1 (see all 5)
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    Cell Line
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    Search LifeMap BioReagents cell lines for MPP1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004385guanylate kinase activity TAS1310897
    GO:0005515protein binding IPI--


    MPP1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for MPP1:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  

    Animal Models:
         Mouse knock-out Mpp1tm1Ahc for MPP1
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mpp1):
     cellular  immune system  reproductive system 

    MPP1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MPP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MPP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/17 Interacting proteins for MPP1 (Q000131, 2, 3 ENSP000003585474) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SGSM2O431472, 3, ENSP000002689894MINT-64870 I2D: score=5 STRING: ENSP00000268989
    STUB1Q9UNE72, 3, ENSP000002195484MINT-65548 I2D: score=5 STRING: ENSP00000219548
    SMN1Q166372, 3MINT-8271311 I2D: score=2 
    SMN2Q166372, 3MINT-8271311 I2D: score=2 
    GADD45AP245222, 3MINT-8255956 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS1713685
    GO:0090022regulation of neutrophil chemotaxis ISS--


    MPP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MPP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MPP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MPP1
    6 Novoseek chemical compound relationships for MPP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 6-phosphate 64.5 3 8601581 (1), 19144827 (1)
    guanylate 44.5 8 8824805 (2), 17572384 (1), 16829577 (1), 8132590 (1) (see all 6)
    ganglioside 6.85 1 17204262 (1)
    lipid 5.14 2 19131362 (1)
    glucose 4.26 1 16516346 (1)
    tyrosine 0 1 2108066 (1)

    Search CenterWatch for drugs/clinical trials and news about MPP1 / EM55 

    Transcripts
    for MPP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MPP1 gene (4 alternative transcripts): 
    NM_001166460.1  NM_001166461.1  NM_001166462.1  NM_002436.3  

    Unigene Cluster for MPP1:

    Membrane protein, palmitoylated 1, 55kDa
    Hs.496984  [show with all ESTs]
    Unigene Representative Sequence: AK093702
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000369534 ENST00000491955 ENST00000482757 ENST00000439370 ENST00000393531
    ENST00000453245 ENST00000494170 ENST00000485256 ENST00000462825 ENST00000493871
    ENST00000393529 ENST00000475943(uc010nvh.2) ENST00000428488 ENST00000488754
    ENST00000417435 ENST00000488694 ENST00000369531 ENST00000471821

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate MPP1 (see all 14):
    hsa-miR-3678-3p hsa-miR-3140-3p hsa-miR-137 hsa-miR-92a hsa-miR-2278 hsa-miR-367 hsa-miR-25 hsa-miR-1271
    SwitchGear 3'UTR luciferase reporter plasmid: MPP1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPP1 (see all 4)
    OriGene shRNA RFP: MPP1
    OriGene siRNA: MPP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPP1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): MPP1 (NM_002436)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPP1

    Additional cDNA sequence: 

    AK093702.1 AK223396.1 AK290246.1 AK303111.1 AK304538.1 AK310681.1 AK311541.1 AK312296.1 
    AK315957.1 AY423731.1 AY634686.1 BC002392.2 M64925.1 

    14 DOTS entries:

    DT.455170  DT.100846113  DT.100846116  DT.100701130  DT.100846098  DT.95108094  DT.100664199  DT.100846106 
    DT.95215464  DT.121320408  DT.100689634  DT.100846103  DT.91749594  DT.91749595 

    24/318 AceView cDNA sequences (see all 318):

    BQ272385 BU178750 F02030 AA401659 CR624495 BU662362 BQ006290 AW243437 
    BQ709095 AI433899 BI757370 AA323460 AU121424 T17236 F05783 C01264 
    BU661837 BM661765 CA432371 AA368927 AW248512 AU185501 CR605122 AW249497 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MPP1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ·
    SP1:                                            -     -     -     -     -                             -                                                     -   
    SP2:                                                  -     -     -     -                             -                                                     -   
    SP3:                                                                    -                             -                                                         
    SP4:                                            -     -     -     -     -           -                 -                                                         
    SP5:                                                                                                  -                                                         

    ExUns: 9d ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b
    SP1:  -                 -     -     -                           
    SP2:  -                                                         
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for MPP1

    Expression
    for MPP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MPP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTGGCACCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MPP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MPP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MPP1

    SOURCE GeneReport for Unigene cluster: Hs.496984

    UniProtKB/Swiss-Prot: EM55_HUMAN, Q00013
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for MPP1
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPP1

    Orthologs
    for MPP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for MPP1 gene from 9/31 species (see all 31)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MPP11 membrane protein, palmitoylated 1, 55kDa 80.33(n)
    83.48(a)    		   422197  NM_001007917.1  NP_001007918.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MPP16
    GUK16
    (see all 3)    		 --
    		 79(a)
    22(a)
    (see all 3)    		 1 ↔ 1
    possible ortholog
    (see all 3)    		 GL343202.1(2111202-2142030)
    6(3239249-3249911)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC535002 similar to membrane protein, palmitoylated 1, 55kDa 74.88(n)    BC047257.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mpp11 membrane protein, palmitoylated 1 65.73(n)
    64.64(a)    		   325542  NM_214692.1  NP_999857.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG118116
    		 --
    		 23(a)
    		 possible ortholog
    		 3L(10684124-10685698)
    worm
    (Caenorhabditis elegans)    		 Secernentea guk-16
    lin-26
    (see all 3)    		 Protein lin-2
    (see all 3)    		 25(a)
    24(a)
    (see all 3)    		 possible ortholog
    1 ↔ 1
    (see all 3)    		 I(3859381-3862732)
    X(12399450-12413957)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons GK-16
    AGK26
    (see all 3)    		 guanylate kinase
    (see all 3)    		 17(a)
    15(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 2(17474619-17477223)
    3(21306723-21309464)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 guanylate kinase, putative, expressed
    		 15(a)
    14(a)
    		 possible ortholog
    possible ortholog
    		 12(20000190-20004313)
    3(11594171-11597778)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria gmk6
    		 guanylate kinase
    		 22(a)
    		 possible ortholog
    		 Chromosome(3819451-3820074)


    ENSEMBL Gene Tree for MPP1 (if available)
    TreeFam Gene Tree for MPP1 (if available) 

    Paralogs
    for MPP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MPP1 gene
    MPP62  MPP72  DLG32  MPP52  DLG22  MPP22  MPP42  DLG42  
    DLG12  CASK2  MPP32  
    9 SIMAP similar genes for MPP1 using alignment to 7 protein entries:     EM55_HUMAN (see all proteins):
    CASK    MPP6    DKFZp666F1010    MPP2    DLG2    MPP5
    MPP7    MPP3    MPP4

    MPP1 for paralogs           About GeneDecksing



    Genomic Variants
    for MPP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/293 NCBI SNPs in MPP1 are shown (see all 293)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1909603671,2
    		--154006610(+) GCGAGG/TCCCTG 4 -- ds50010--------
    rs128508361,2
    		C,H--154006659(+) CCCCAG/TCCCTG 4 -- ds50011Minor allele frequency- T:0.00NS 286
    rs1834095511,2
    		--154006877(+) GGCATC/TTTGTG 4 -- ds50010--------
    rs1134547251,2
    		C--154006960(+) GTCATA/C/TGGCAT 8 -- ut311CSA 1
    rs1889637711,2
    		--154006978(+) CAGCAC/TTTTTA 4 -- ut310--------
    rs1925059091,2
    		--154007008(+) TAGAGA/CAGACA 4 -- ut310--------
    rs1828001011,2
    		--154007110(+) AGCATA/GTACAG 4 -- ut310--------
    rs18041511,2
    		C--154007120(-) TTGCCT/CTCAAC 4 -- ut31 ese33Minor allele frequency- C:0.00MN NA 188
    rs10427021,2
    		C--154007142(-) TCCCTC/TTAAAG 4 -- ut31 ese32Minor allele frequency- T:0.00NA 4
    rs1880082861,2
    		--154007200(+) TTTTGC/GTAGTA 4 -- ut310--------

    HapMap Linkage Disequilibrium report for MPP1 (154006959 - 154049282 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for MPP1
         2 CNVs: 52965 23331
    Locus Specific Mutation Databases (LSDB): MPP1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPP1
    DNA2.0 Custom Variant and Variant Library Synthesis for MPP1

    Disorders / Diseases
    for MPP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MPP1 for disorders           About GeneDecksing

    OMIM gene information: 305360    OMIM disorders: --

    20/33 diseases for MPP1 (see all 33):    About MalaCards
    extramedullary plasmacytoma    anaplastic large cell lymphoma    burkitt's lymphoma    idiopathic pulmonary fibrosis
    oral squamous cell carcinoma    acquired immunodeficiency syndrome    plasmacytoma    squamous cell carcinoma
    pulmonary fibrosis    papillary thyroid carcinoma    ehrlichiosis    tetanus
    chronic myeloid leukemia    folliculitis    myeloid leukemia    hodgkin's lymphoma
    thyroid carcinoma    myelodysplastic syndrome    nasopharyngitis    fibrosis

    10/20 Novoseek disease relationships for MPP1 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nasopharyngeal carcinoma 79.6 19 11448908 (1), 15565804 (1), 17103409 (1), 18710612 (1) (see all 19)
    ebv infections 69.2 1 9769285 (1)
    burkitt lymphoma 59 2 10092782 (1), 8157362 (1)
    latent infection 58.1 9 10602470 (1), 11932422 (1), 7859281 (1), 10451485 (1) (see all 8)
    hodgkin disease 44.6 6 17379070 (2), 12796376 (1), 1328576 (1), 9354006 (1) (see all 5)
    lymphoma 37.4 2 9367385 (1), 11781710 (1)
    tumors 35.7 15 9769285 (1), 7590743 (1), 12607539 (1), 19638292 (1) (see all 14)
    necrosis 18.3 6 8733441 (2), 12607539 (1), 11007952 (1), 15322249 (1) (see all 5)
    metastasis 10.7 3 18710612 (1), 16718270 (1), 12168795 (1)
    tetanus 8.39 1 17335083 (1)


    Export disorders for MPP1 gene to outside databases

    Publications
    for MPP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MPP1 gene, integrated from 9 sources (see all 224):
    (articles sorted by number of sources associating them with MPP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif. (PubMed id 1713685)1, 2, 3 Ruff P.... Husain-Chishti A. (1991)
    2. The gene encoding the palmitoylated erythrocyte membrane protein, p55, originates at the CpG island 3' to the factor VIII gene. (PubMed id 1301163)1, 2, 9 Metzenberg A.B. and Gitschier J. (1992)
    3. Identification of erythrocyte p55/MPP1 as a binding partner of NF2 tumor suppressor protein/Merlin. (PubMed id 19144871)1, 2, 9 Seo P.-S.... Chishti A.H. (2009)
    4. Palmitoylation of MPP1 (membrane-palmitoylated protein 1)/p55 is crucial for lateral membrane organization in erythroid cells. (PubMed id 22496366)1, 2 Lach A.... Sikorski A.F. (2012)
    5. MPP1 links the Usher protein network and the Crumbs protein complex in the retina. (PubMed id 17584769)1, 2 Gosens I.... Roepman R. (2007)
    6. Solution structure of human erythroid p55 PDZ domain. (PubMed id 16741958)1, 2 Kusunoki H. and Kohno T. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Complete genomic organization of the human erythroid p55 gene (MPP1), a membrane-associated guanylate kinase homologue. (PubMed id 8824805)1, 9 Kim A.C....Chishti A.H. (1996)
    10. Alternatively spliced exon 5 of the FERM domain of pr otein 4.1R encodes a novel binding site for erythrocyte p55 and is critical for membrane targeting in epithelial cells. (PubMed id 18952129)1, 9 Seo P.S....Chishti A.H. (2009)

    External Searches for MPP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing MPP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4354 HGNC: 7219 AceView: MPP1 Ensembl:ENSG00000130830 euGenes: HUgn4354
    ECgene: MPP1 H-InvDB: MPP1

    Other Databases showing MPP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MPP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MPP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MPP1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MPP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MPP1 gene:
    Search GeneIP for patents involving MPP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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