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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MPO Gene

protein-coding   GIFtS: 70
GCID: GC17M056347

Myeloperoxidase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
myeloperoxidase1 2
EC 1.11.2.23
EC 1.11.18
EC 1.11.1.78

External Ids:    HGNC: 72181   Entrez Gene: 43532   Ensembl: ENSG000000053817   OMIM: 6069895   UniProtKB: P051643   

Export aliases for MPO gene to outside databases

Previous GC identifers: GC17M056091 GC17M058828 GC17M056689 GC17M056821 GC17M053702 GC17M051708


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MPO Gene:
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major
component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is
subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light
chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of
netrophils. (provided by RefSeq, Jul 2008)

GeneCards Summary for MPO Gene: 
MPO (myeloperoxidase) is a protein-coding gene. Diseases associated with MPO include myeloperoxidase deficiency, and myeloid sarcoma, and among its related super-pathways are Phenytoin Pathway, Pharmacokinetics and Immune response IL-23 signaling pathway. GO annotations related to this gene include chromatin binding and heparin binding. An important paralog of this gene is LPO.

UniProtKB/Swiss-Prot: PERM_HUMAN, P05164
Function: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal
activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous
acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance
PMN microbicidal activity

Gene Wiki entry for MPO (Myeloperoxidase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MPO gene promoter:
         NRF-2   Sp1   AML1a   Msx-1   ITF-2   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMPO promoter sequence
   Search SABiosciences Chromatin IP Primers for MPO

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.1   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q21.3-q23

MPO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPO gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M056347:  view genomic region     (about GC identifiers)

Start:
56,347,217 bp from pter      End:
56,358,296 bp from pter
Size:
11,080 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PERM_HUMAN, P05164 (See protein sequence)
Recommended Name: Myeloperoxidase precursor  
Size: 745 amino acids; 83869 Da
Cofactor: Binds 1 calcium ion per monomer
Cofactor: Binds 1 heme B (iron-protoporphyrin IX) group covalently per monomer
Subunit: Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain
Subcellular location: Lysosome
6/13 PDB 3D structures from and Proteopedia for MPO (see all 13):
1CXP (3D)        1D2V (3D)        1D5L (3D)        1D7W (3D)        1DNU (3D)        1DNW (3D)    
Secondary accessions: A1L4B8 Q14862 Q4PJH5 Q9UCL7
Alternative splicing: 3 isoforms:  P05164-1   P05164-2   P05164-3   

Explore the universe of human proteins at neXtProt for MPO: NX_P05164

Explore proteomics data for MPO at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P05164

  • 4/7 DME Specific Peptides for MPO (P05164) (see all 7)
     RDGDRFW  PCFLAGD  LTSMHTL  LMFMQWGQ 

    MPO Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MPO Protein Expression
    REFSEQ proteins: NP_000241.1  
    ENSEMBL proteins: 
     ENSP00000225275   ENSP00000464668   ENSP00000344419  

    Human Recombinant Protein Products for MPO: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MPO (Myeloperoxidase/MPO)
    Enzo Life Sciences proteins for MPO
    OriGene Purified Protein for MPO
    OriGene Protein Over-expression Lysate for MPO
    OriGene MassSpec for MPO 
    OriGene Custom Protein Services for MPO
    GenScript Custom Purified and Recombinant Proteins Services for MPO
    Novus Biologicals MPO Proteins
    Novus Biologicals MPO Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MPO
    Cloud-Clone Corp. Proteins for MPO 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA10772654
    GO:0005634nucleus TAS2829220
    GO:0005739mitochondrion IEA--
    GO:0005764lysosome IEA--
    GO:0030141secretory granule IDA11907569

    MPO for ontologies           About GeneDecksing



    MPO Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MPO
    R&D Systems Antibodies for MPO (Myeloperoxidase/MPO)
    Cell Signaling Technology (CST) Antibodies for MPO 
    OriGene Antibodies for MPO
    OriGene Custom Antibody Services for MPO
    GenScript Custom Superior Antibodies Services for MPO
    Novus Biologicals MPO Antibodies
    Abcam antibodies for MPO
    Cloud-Clone Corp. Antibodies for MPO 
    ThermoFisher Antibody for MPO
    LSBio Antibodies in human, mouse, rat for MPO 

    Assay Products for MPO: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MPO
    R&D Systems ELISAs for MPO (Myeloperoxidase/MPO)         (see all)
    GenScript Custom Assay Services for MPO
    Enzo Life Sciences assays for MPO
    Cloud-Clone Corp. ELISAs for MPO 
    Cloud-Clone Corp. CLIAs for MPO


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR010255 Haem_peroxidase
     IPR019791 Haem_peroxidase_animal_subgr
     IPR002007 Haem_peroxidase_animal

    Graphical View of Domain Structure for InterPro Entry P05164

    ProtoNet protein and cluster: P05164

    2 Blocks protein domains:
    IPB002007 Animal haem peroxidase signature
    IPB010255 Haem peroxidase


    UniProtKB/Swiss-Prot: PERM_HUMAN, P05164
    Similarity: Belongs to the peroxidase family. XPO subfamily


    MPO for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PERM_HUMAN, P05164
    Function: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal
    activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous
    acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance
    PMN microbicidal activity
    Catalytic activity: Cl(-) + H(2)O(2) + H(+) = HClO + H(2)O
    Catalytic activity: Cl(-) + H(2)O(2) = HOCl + 2 H(2)O

         Genatlas biochemistry entry for MPO:
    myeloperoxidase,formed by dimerization of hemi-MPO,78kDa,cleaved in an alpha large (59kDa) iron binding subunit
    and two smaller beta subunits (13kDa),expressed in azurophilic granules of neutrophils and primary liposomes of
    monocytes,involved in oxygen dependent mechanism of phagocytosis

         Enzyme Numbers (IUBMB): EC 1.11.12 EC 1.11.1.72 EC 1.11.2.21

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding TAS2829220
    GO:0004601peroxidase activity IDA10772654
    GO:0008201heparin binding IDA11907569
    GO:0020037heme binding IEA--
    GO:0046872metal ion binding IEA--
         
    MPO for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MPO:
     Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mpo):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     muscle 

    MPO for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MPO: Mpotm1Mae Mpotm1Lus

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MPO 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MPO

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MPO 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MPO 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPO
    1 QIAGEN miScript miRNA Assays for microRNA that regulate MPO:
    hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmidMPO 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MPO
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MPO

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MPO (see all 7)
    OriGene ORF clones in mouse, rat for MPO
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MPO (NM_000250)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPO
    Sirion Biotech Customized lentivirus for stable overexpression of MPO 
                         Customized lentivirus expression plasmids for stable overexpression of MPO 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MPO
    Search LifeMap BioReagents cell lines for MPO
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPO


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MPO About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Carbamazepine Pathway, Pharmacokinetics
    Carbamazepine Pathway, Pharmacokinetics0.38
    2Development PDGF signaling via STATs and NF-kB
    IL23-mediated signaling events0.38
    3amb2 Integrin signaling
    amb2 Integrin signaling
    4Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    5Selenium Pathway
    Selenium Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MPO
        LDL Oxidation in Atherogenesis

    1 Cell Signaling Technology (CST) Pathway for MPO
        Lymphocyte Signaling

    5 BioSystems Pathways for MPO
        Selenium Pathway
    Folate Metabolism
    IL23-mediated signaling events
    C-MYB transcription factor network
    amb2 Integrin signaling

    3 PharmGKB Pathways for MPO
        Carbamazepine Pathway, Pharmacokinetics
    Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
    Platinum Pathway, Pharmacokinetics/Pharmacodynamics

    2         Kegg Pathways  (Kegg details for MPO):
        Phagosome
    Transcriptional misregulation in cancer


    MPO for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MPO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/42 Interacting proteins for MPO (P051642, 3 ENSP000002252754) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPP004503, ENSP000002646134I2D: score=2 STRING: ENSP00000264613
    ATP6V1B2P212812, ENSP000002763904MINT-4054731 STRING: ENSP00000276390
    A2MP010232MINT-4054731
    ACTBP607092MINT-4054731
    ALPPP051872MINT-4054731
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001878response to yeast IEA--
    GO:0002149hypochlorous acid biosynthetic process IEA--
    GO:0002679respiratory burst involved in defense response IEA--
    GO:0006952defense response TAS8621627
    GO:0006979response to oxidative stress TAS2903767

    MPO for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MPO for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MPO (PERM)

    10/14 HMDB Compounds for MPO (see all 14)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CarnosineBeta-Alanyl-L-histidine (see all 14)305-84-08529024
    Melatonin5-Methoxy-N-acetyltryptamine (see all 23)73-31-415636586
    2-PhenylacetamideBenzeneacetamide (see all 10)103-81-1--
    4-Coumaryl alcohol3-(4-Hydroxyphenyl)-1-propane (see all 12)1076-38-6--
    CalciumCa (see all 2)7440-70-2--
    Cyanosulfurous acid anionCNSu;cyanosulfurous acid ----
    FormaldehydeAldeide formica (see all 16)50-00-0--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    HypothiocyaniteCyanosulfoxylate;Hypothiocyanite;OSCN-Hypothiocyanite ion;N,6-didehydro-3,6-dihydro-3-methyl-Adenosine 63296-34-4--

    10/22 DrugBank Compounds for MPO (see all 22)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    PropylthiouracilProcasil (see all 15)51-52-5enzymeinhibitor17070108 6096612 2159305 2837228
    Cysteamine(2-Mercaptoethyl)amine (see all 19)60-23-1enzymesubstrate2829860 8381104 2852004
    Aminosalicylic Acid4-aminosalicylic acid (see all 10)65-49-6enzymeinhibitor16614956 2563347
    CisplatinCDDP (see all 7)15663-27-1enzymeinducer14745844 19818462
    Human Serum Albumin-- 9048-49-1enzymesubstrate16443167 16125131
    MelatoninMEL (see all 4)73-31-4targetinhibitor18237195
    enzymesubstrate inhibitor18237195 15636586
    OctreotideOctreotida [Spanish] (see all 3)83150-76-9enzymeinhibitor10929949 11020872
    Bivalirudin-- 128270-60-0enzymeinhibitor18701766
    Calcipotriol-- 112965-21-6enzymeinhibitor12928540
    CefaclorCCL (see all 4)53994-73-3enzymeinducer11675909

    10/154 Novoseek inferred chemical compound relationships for MPO gene (see all 154)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hocl 94.8 691 18296711 (6), 1321719 (5), 8390258 (5), 9544578 (4) (see all 99)
    3-chlorotyrosine 86.4 50 18314009 (8), 15466253 (3), 19030913 (3), 9151778 (3) (see all 22)
    4-aminobenzoic acid hydrazide 82.9 31 9020887 (5), 15878909 (2), 17875773 (1), 11738154 (1) (see all 14)
    hobr 82.3 46 16125131 (3), 17604010 (2), 8619607 (2), 16732739 (2) (see all 16)
    h2o2 79.9 617 1319066 (6), 15878909 (5), 9686606 (4), 14613914 (4) (see all 99)
    chlorohydrins 77.6 6 12614844 (2), 11677044 (1), 17604010 (1), 8060981 (1) (see all 5)
    monochlorodimedone 77.2 9 10984130 (2), 18475677 (1), 2155024 (1), 1656885 (1) (see all 7)
    chloramines 77.1 18 8520754 (2), 8877407 (2), 15663478 (2), 11297432 (1) (see all 13)
    superoxide 77 375 17381162 (8), 8751892 (5), 11368132 (4), 17159802 (4) (see all 99)
    hypothiocyanite 76.5 14 9265925 (2), 11968939 (1), 9359420 (1), 8997439 (1) (see all 12)

    Search CenterWatch for drugs/clinical trials and news about MPO / PERM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MPO gene: 
    NM_000250.1  

    Unigene Cluster for MPO:

    Myeloperoxidase
    Hs.458272  [show with all ESTs]
    Unigene Representative Sequence: NM_000250
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225275(uc002ivu.1) ENST00000577220 ENST00000578493 ENST00000581022
    ENST00000580005 ENST00000340482
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate MPO:
    hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmidMPO 3' UTR sequence
    Inhib. RNA
    Products:
         
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    GenScript: all cDNA clones in your preferred vector: MPO (NM_000250)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPO
    Sirion Biotech Customized lentivirus for stable overexpression of MPO 
                         Customized lentivirus expression plasmids for stable overexpression of MPO 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MPO
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPO
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPO

    Additional mRNA sequence: 

    BC130476.1 J02694.1 M19507.1 S56200.1 X04876.1 

    18 DOTS entries:

    DT.313994  DT.100772871  DT.92455127  DT.95363907  DT.92416015  DT.95334510  DT.95373051  DT.70102226 
    DT.91923291  DT.92455128  DT.100772870  DT.100060706  DT.120927371  DT.92455106  DT.95139332  DT.100772874 
    DT.92455101  DT.95272085 

    24/271 AceView cDNA sequences (see all 271):

    BI028047 M19507 BQ335100 AJ713081 BI032260 BF899416 AI056254 BQ188214 
    AJ713355 T28009 AA954479 BF877356 BF893744 BF895799 AJ712944 BQ335450 
    NM_000250 S56200 BQ335443 BI056476 J02694 BX106821 BI021931 BI020067 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MPO    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:                    -                                               -                 -                                             
    SP2:                                                                    -                 -     -     -                                 
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for MPO

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MPO expression in normal human tissues (normalized intensities)      MPO embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCCCCTTT
    MPO Expression
    About this image


    MPO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 7 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Bone marrow-derived hematopoietic stem cells
             lung ; macrophages   
             bone marrow mononuclear cells   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             bone marrow   
     
     Thymus (Hematopoietic System)
             Thymus
     
     Lung (Respiratory System)
             lung ; macrophages   
     
     Pancreas (Endocrine System)
             visceral organ/gut/foregut-midgut junction   

    See MPO Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MPO

    SOURCE GeneReport for Unigene cluster: Hs.458272
        SABiosciences Expression via Pathway-Focused PCR Arrays including MPO (see all 8): 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat
              Drug Metabolism in human mouse rat
              Antibacterial Response in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MPO gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mpo1 , 5 myeloperoxidase1, 5 84.89(n)1
    86.47(a)1
      11 (52.22 cM)5
    175231  NM_010824.21  NP_034954.21 
     877935815 
    chicken
    (Gallus gallus)
    Aves MPO1 myeloperoxidase 63.95(n)
    61.38(a)
      417467  XM_415716.3  XP_415716.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    MPO6
    myeloperoxidase
    59(a)
    36(a)
    possible ortholog
    1 ↔ 1
    AAWZ02037755(870-14726)
    GL344475.1(1626-12418)
    African clawed frog
    (Xenopus laevis)
    Amphibia mpo-A2 myeloperoxidase, peroxidase 2' 73.67(n)    BC048774.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mpx6
    CU184832.26
    Uncharacterized protein
    39(a)
    39(a)
    1 ↔ many
    possible ortholog
    10(6807370-6814445)
    25(3089241-3105516)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG58733 peroxidase 34(a)
    (best of 6)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea C46A5.43 peroxidase 36(a)
    (best of 5)
      IV(7748401-7756132)   --


    ENSEMBL Gene Tree for MPO (if available)
    TreeFam Gene Tree for MPO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MPO gene
    LPO2  TPO2  EPX2  PXDNL2  PXDN2  
    5 SIMAP similar genes for MPO using alignment to 3 protein entries:     PERM_HUMAN (see all proteins):
    EPX    LPO    TPO    PXDN    PXDNL

    MPO for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/412 SNPs in MPO are shown (see all 412)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0153794
    Myeloperoxidase deficiency (MPOD)4--see VAR_0153792 R W mis40--------
    VAR_0365174
    A colorectal cancer sample4--see VAR_0365172 R Q mis40--------
    rs563787161,2,4
    C,FMyeloperoxidase deficiency (MPOD)4 pathogenic157372083(-) ACTCAT/CGTTCA 2 /T /M mis12Minor allele frequency- C:0.01NA EU 5007
    rs789509391,2,4
    C,FMyeloperoxidase deficiency (MPOD)4 pathogenic157372495(+) TGCGGT/CATTTG 2 /Y /C mis11Minor allele frequency- C:0.00NA 4492
    rs1194680101,2
    C,Fpathogenic157365779(-) AGATCC/TGGGAG 2 R W mis12Minor allele frequency- T:0.00NA EU 5871
    rs287308371,2
    C,Fpathogenic157370978(-) CAACGC/TGCTCA 2 A V mis13Minor allele frequency- T:0.01NS NA EU 5951
    rs606041711,2
    C--51712415(+) GTGTG-/GA/TG 
     
    /TGTGTG
    AGTGT
    2 -- int1 cds11CSA 2
    rs720511821,2
    C--56351709(+) TAGGA-/GTGTGTG 1 -- int10--------
    rs355500021,2
    C,F--56352284(-) GGCGCT/CGCTGC 1 -- int15Minor allele frequency- C:0.00NS 182
    rs346266461,2
    C,F--57362556(-) ACTGTG/AGTCAC 1 -- ds50015Minor allele frequency- A:0.01NS 178

    HapMap Linkage Disequilibrium report for MPO (56347217 - 56358296 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MPO:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509663CNV Insertion20534489
    nsv2109CNV Loss18451855
    nsv517229CNV Gain+Loss19592680


    Human Gene Mutation Database (HGMD): MPO

    Locus Specific Mutation Databases (LSDB): MPO
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MPO
    DNA2.0 Custom Variant and Variant Library Synthesis for MPO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606989   
    OMIM disorders: 254600  104300  
    UniProtKB/Swiss-Prot: PERM_HUMAN, P05164
  • Myeloperoxidase deficiency (MPOD) [MIM:254600]: A disorder characterized by decreased myeloperoxidase
    activity in neutrophils and monocytes that results in disseminated candidiasis. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 20/282 diseases for MPO (see all 282):    About MalaCards
    myeloperoxidase deficiency    myeloid sarcoma    rapidly progressive glomerulonephritis    complication in hemodialysis
    mononeuritis multiplex    lung cancer, protection against    mononeuritis    microscopic polyangiitis
    crescentic glomerulonephritis    goodpasture syndrome    eosinophil peroxidase deficiency    cogan's syndrome
    acute undifferentiated leukemia    blastic plasmacytoid dendritic cell    raynaud disease    leukostasis
    cd4+/cd56+ hematodermic neoplasm    histiocytic sarcoma    extrahepatic cholestasis    natural killer cell leukemia

    20/23 diseases from the University of Copenhagen DISEASES database for MPO (see all 23):
    Vasculitis     Glomerulonephritis     Lung disease     Inflammatory bowel disease
    Leukemia     Myeloid sarcoma     Hypersensitivity reaction type II disease     Pancreatitis
    Atherosclerosis     Heart disease     Leukopenia     Kidney failure
    Arthritis     Pleurisy     Mononeuropathy     Skin disease
    Periodontal disease     Peripheral vascular disease     Chediak-Higashi syndrome     Peritonitis

    MPO for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/92 Novoseek inferred disease relationships for MPO gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mpo deficiency 93.3 230 1655065 (7), 7904599 (7), 7948307 (6), 10482305 (6) (see all 80)
    vasculitis 86.5 359 10229138 (5), 15730737 (5), 17070108 (5), 18806928 (4) (see all 99)
    wegeners granulomatosis 83.7 62 12422006 (2), 17521322 (2), 8059116 (2), 7994909 (1) (see all 41)
    inflammation 79 400 18617697 (3), 19297613 (3), 8206644 (3), 2177221 (3) (see all 99)
    glomerulonephritis 77.8 129 19238910 (3), 19264905 (3), 8082301 (3), 17579266 (3) (see all 73)
    sarcoma granulocytic 77.4 14 9038763 (1), 15738870 (1), 17700206 (1), 11020993 (1) (see all 14)
    churg-strauss syndrome 77 29 1677531 (1), 10481446 (1), 12687504 (1), 17521322 (1) (see all 20)
    glomerulonephritis rapidly progressive 73.7 11 7611243 (2), 9097926 (1), 16076370 (1), 19601559 (1) (see all 7)
    acute leukemia 72.9 99 19935430 (3), 9725460 (3), 8396697 (2), 17479404 (2) (see all 55)
    colitis 72.7 85 9200288 (3), 17934837 (3), 7986968 (2), 8769290 (2) (see all 51)

    Genatlas disease: MPO
    infections,recurrent,with disseminated candidiasis

    Genetic Association Database (GAD): MPO
    Human Genome Epidemiology (HuGE) Navigator: MPO (210 documents)

    Export disorders for MPO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MPO gene, integrated from 9 sources (see all 3074):
    (articles sorted by number of sources associating them with MPO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Melatonin is a potent inhibitor for myeloperoxidase. (PubMed id 18237195)1, 7, 9 Galijasevic S....Abu-Soud H.M. (2008)
    2. Myeloperoxidase (MPO) gene mutation in hereditary MPO deficiency. (PubMed id 8142659)1, 2, 9 Kizaki M.... Koeffler H.P. (1994)
    3. Biochemical and molecular characterization of hereditary myeloperoxidase deficiency. (PubMed id 9354683)1, 2, 9 Romano M.... Baralle F.E. (1997)
    4. Effect of the R569W missense mutation on the biosynthesis of myeloperoxidase. (PubMed id 8621627)1, 2, 9 Nauseef W.... McCormick S. (1996)
    5. Association between myeloperoxidase polymorphisms and its plasma levels with severity of coronary artery disease. (PubMed id 19651119)1, 4, 9 Wainstein R.V....Polanczyk C.A. (2010)
    6. Functional variants in the catalase and myeloperoxida se genes, ambient air pollution, and respiratory-related school absences: an ex ample of epistasis in gene-environment interactions. (PubMed id 19897513)1, 4, 9 Wenten M....Gilliland F.D. (2009)
    7. Polymorphisms of tumor necrosis factor and myeloperoxidase genes in patients with chronic renal failure on peritoneal dialysis. (PubMed id 15068388)1, 4, 9 Buraczynska K....Ksiazek A. (2003)
    8. Hereditary myeloperoxidase deficiency due to a missense mutation of arginine 569 to tryptophan. (PubMed id 7904599)1, 2, 9 Nauseef W.M.... Cogley M. (1994)
    9. Genetic variation of myeloperoxidase gene contributes to atopic asthma susceptibility: a preliminary association study in Russian po pulation. (PubMed id 19544176)1, 4, 9 Polonikov A.V....Ivanov V.P. (2009)
    10. No relationship between neutrophil granulocyte activa tion and the myeloperoxidase gene - 129 G>A and - 463 G>A promoter polymo rphisms: implications for investigations of cardiovascular disease. (PubMed id 19877306)1, 4, 9 Videm V. and Olsen G.D. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4353 HGNC: 7218 AceView: MPO Ensembl:ENSG00000005381 euGenes: HUgn4353
    ECgene: MPO Kegg: 4353 H-InvDB: MPO

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MPO Pharmacogenomics, SNPs, Pathways
    MPObasehttp://bioinf.uta.fi/MPObase/
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mpo/
    Wikipedia http://en.wikipedia.org/wiki/Myeloperoxidase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MPO gene:
    Search GeneIP for patents involving MPO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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