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Aliases for MPO Gene

Aliases for MPO Gene

  • Myeloperoxidase 2 3 3 5
  • EC 1.11.1.7 61
  • EC 1.11.2.2 4
  • EC 1.11.1 61

External Ids for MPO Gene

Previous GeneCards Identifiers for MPO Gene

  • GC17M056091
  • GC17M058828
  • GC17M056689
  • GC17M056821
  • GC17M053702
  • GC17M056347
  • GC17M051708

Summaries for MPO Gene

Entrez Gene Summary for MPO Gene

  • Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]

GeneCards Summary for MPO Gene

MPO (Myeloperoxidase) is a Protein Coding gene. Diseases associated with MPO include Myeloperoxidase Deficiency and Alzheimer Disease. Among its related pathways are Phenytoin Pathway, Pharmacokinetics and LDL Oxidation in Atherogenesis. GO annotations related to this gene include chromatin binding and heme binding. An important paralog of this gene is EPX.

UniProtKB/Swiss-Prot for MPO Gene

  • Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Gene Wiki entry for MPO Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPO Gene

Genomics for MPO Gene

Regulatory Elements for MPO Gene

Enhancers for MPO Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G058281 0.9 FANTOM5 ENCODE 26.4 +2.5 2514 0.6 ZNF579 NFYB IKZF1 MAX FOS MPO TSPOAP1 LOC105371841
GH17G058284 1.3 FANTOM5 Ensembl ENCODE 11.7 -0.5 -475 1.2 CEBPB MAX CEBPG ATF2 IRF9 ZFHX2 JUND ATF3 POLR2A ETV4 TSPOAP1 MPO MKS1 LPO RNF43 SUPT4H1 SRSF1 GC17P058303
GH17G058327 1.8 FANTOM5 ENCODE dbSUPER 3.5 -53.3 -53345 20.8 CREB3L1 AGO1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 NFYC TBX21 MEF2D SUPT4H1 TSPOAP1 TRIM37 VEZF1 SRSF1 DYNLL2 TEX14 MTMR4 MPO RAD51C
GH17G057573 0.7 dbSUPER 4.8 +710.2 710212 1.8 MAZ TAF1 ZNF394 ZNF2 YY1 OSR2 GLIS1 ZNF629 PATZ1 ZBTB33 MPO LOC101927539 ENSG00000280028
GH17G058287 1.1 Ensembl ENCODE 0.4 -5.3 -5288 3.6 HDAC1 PKNOX1 NFIB TCF12 FOS ZEB2 NFIC PRDM6 SMARCA4 PBX2 TSPOAP1 SUPT4H1 LPO HSF5 RNF43 MPO GC17P058303
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MPO on UCSC Golden Path with GeneCards custom track

Genomic Location for MPO Gene

Chromosome:
17
Start:
58,269,855 bp from pter
End:
58,284,313 bp from pter
Size:
14,459 bases
Orientation:
Minus strand

Genomic View for MPO Gene

Genes around MPO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPO Gene

Proteins for MPO Gene

  • Protein details for MPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05164-PERM_HUMAN
    Recommended name:
    Myeloperoxidase
    Protein Accession:
    P05164
    Secondary Accessions:
    • A1L4B8
    • Q14862
    • Q4PJH5
    • Q9UCL7

    Protein attributes for MPO Gene

    Size:
    745 amino acids
    Molecular mass:
    83869 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=heme b; Xref=ChEBI:CHEBI:60344;
    Quaternary structure:
    • Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain.

    Three dimensional structures from OCA and Proteopedia for MPO Gene

    Alternative splice isoforms for MPO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPO Gene

Selected DME Specific Peptides for MPO Gene

P05164:
  • RDGDRFW
  • LTSMHTL
  • EGGIDPILRGL
  • PCFLAGD
  • LMFMQWGQ
  • RDHGLPGYN
  • RFQDNGRAL

Post-translational modifications for MPO Gene

  • Glycosylation at posLast=139139, posLast=323323, Asn355, posLast=391391, Asn483, and Asn729
  • Modification sites at PhosphoSitePlus

Other Protein References for MPO Gene

ENSEMBL proteins:
REFSEQ proteins:

Assay Products

Domains & Families for MPO Gene

Suggested Antigen Peptide Sequences for MPO Gene

Graphical View of Domain Structure for InterPro Entry

P05164

UniProtKB/Swiss-Prot:

PERM_HUMAN :
  • Belongs to the peroxidase family. XPO subfamily.
Family:
  • Belongs to the peroxidase family. XPO subfamily.
genes like me logo Genes that share domains with MPO: view

No data available for Gene Families for MPO Gene

Function for MPO Gene

Molecular function for MPO Gene

GENATLAS Biochemistry:
myeloperoxidase,formed by dimerization of hemi-MPO,78kDa,cleaved in an alpha large (59kDa) iron binding subunit and two smaller beta subunits (13kDa),expressed in azurophilic granules of neutrophils and primary liposomes of monocytes,involved in oxygen dependent mechanism of phagocytosis
UniProtKB/Swiss-Prot CatalyticActivity:
Cl(-) + H(2)O(2) + H(+) = HClO + H(2)O.
UniProtKB/Swiss-Prot Function:
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Enzyme Numbers (IUBMB) for MPO Gene

Gene Ontology (GO) - Molecular Function for MPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding TAS 2829220
GO:0004601 peroxidase activity IEA,IDA 10772654
GO:0008201 heparin binding IDA 11907569
GO:0016491 oxidoreductase activity IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with MPO: view
genes like me logo Genes that share phenotypes with MPO: view

Human Phenotype Ontology for MPO Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MPO Gene

MGI Knock Outs for MPO:

Animal Model Products

CRISPR Products

miRNA for MPO Gene

miRTarBase miRNAs that target MPO

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MPO

No data available for Transcription Factor Targets and HOMER Transcription for MPO Gene

Localization for MPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPO Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPO gene
Compartment Confidence
extracellular 5
nucleus 5
lysosome 5
plasma membrane 3
mitochondrion 3
cytoskeleton 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 10772654
GO:0005634 nucleus IDA,TAS 21630459
GO:0005739 mitochondrion IEA --
GO:0005764 lysosome TAS 8621627
genes like me logo Genes that share ontologies with MPO: view

Pathways & Interactions for MPO Gene

genes like me logo Genes that share pathways with MPO: view

Gene Ontology (GO) - Biological Process for MPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001878 response to yeast IEA --
GO:0002149 hypochlorous acid biosynthetic process IEA --
GO:0002679 respiratory burst involved in defense response IEA --
GO:0006952 defense response TAS,IEA 8621627
GO:0006979 response to oxidative stress IEA,TAS 2903767
genes like me logo Genes that share ontologies with MPO: view

No data available for SIGNOR curated interactions for MPO Gene

Drugs & Compounds for MPO Gene

(94) Drugs for MPO Gene - From: DrugBank, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist, Enzyme, Other 848,265
Propylthiouracil Approved Pharma Enzyme, inhibitor 9
Aminosalicylic Acid Approved Pharma Enzyme, inhibitor 30
Calcipotriol Approved Pharma Agonist, Enzyme, inhibitor Vitamin D3 analog,regulates cell differentiation and proliferation, Vitamin D3 analog 0
Cefaclor Approved Pharma Enzyme, inducer 5

(97) Additional Compounds for MPO Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Carnosine
  • b-Alanyl-L-histidine
  • b-Alanylhistidine
  • beta-Alanyl-L-histidine
  • beta-Alanylhistidine
  • Carnosine
305-84-0
Hypothiocyanite
  • Cyanosulfoxylate
  • Hypothiocyanite
  • N,6-Didehydro-3,6-dihydro-3-methyl-Adenosine
  • OSCN-Hypothiocyanite ion
63296-34-4
2-Phenylacetamide
  • (alpha-)2-Phenylacetamide
  • 2-Phenyl-Acetamide
  • alpha-Phenylacetamide
  • alpha-Toluamide
  • alpha-Toluimidic acid
103-81-1
7-Hydroxyticlopidine
  • Hydroxyticlopidine
  • M1
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with MPO: view

Transcripts for MPO Gene

Unigene Clusters for MPO Gene

Myeloperoxidase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MPO

Alternative Splicing Database (ASD) splice patterns (SP) for MPO Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5:

Relevant External Links for MPO Gene

GeneLoc Exon Structure for
MPO
ECgene alternative splicing isoforms for
MPO

Expression for MPO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MPO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MPO Gene

This gene is overexpressed in Whole Blood (x38.6) and Spleen (x4.6).

Protein differential expression in normal tissues from HIPED for MPO Gene

This gene is overexpressed in Neutrophil (37.9), Monocytes (10.5), and Nasal epithelium (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MPO Gene



Protein tissue co-expression partners for MPO Gene

NURSA nuclear receptor signaling pathways regulating expression of MPO Gene:

MPO

SOURCE GeneReport for Unigene cluster for MPO Gene:

Hs.458272

Evidence on tissue expression from TISSUES for MPO Gene

  • Blood(5)
  • Bone marrow(4.8)
  • Liver(4.6)
  • Saliva(4.3)
  • Nervous system(4)
  • Lung(3.5)
  • Intestine(3.4)
  • Heart(2.9)
  • Kidney(2.6)
  • Skin(2.4)
  • Spleen(2.4)
  • Muscle(2.1)
  • Pancreas(2.1)
  • Lymph node(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MPO Gene

Germ Layers:
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • lymphatic
Organs:
Thorax:
  • thymus
Abdomen:
  • liver
  • spleen
General:
  • blood
  • bone marrow
  • coagulation system
  • red blood cell
  • white blood cell
genes like me logo Genes that share expression patterns with MPO: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MPO Gene

Orthologs for MPO Gene

This gene was present in the common ancestor of animals.

Orthologs for MPO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MPO 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia MPO 34 35
  • 87.53 (n)
cow
(Bos Taurus)
Mammalia MPO 34 35
  • 87.14 (n)
mouse
(Mus musculus)
Mammalia Mpo 34 16 35
  • 85.02 (n)
oppossum
(Monodelphis domestica)
Mammalia MPO 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MPO 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves MPO 34
  • 64.96 (n)
-- 35
  • 60 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496213 34
  • 60.9 (n)
Str.11704 34
African clawed frog
(Xenopus laevis)
Amphibia mpo-A 34
zebrafish
(Danio rerio)
Actinopterygii mpx 35
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5873 36
  • 34 (a)
CG10211 36
  • 33 (a)
CG6969 36
  • 33 (a)
CG6879 36
  • 32 (a)
CG4009 36
  • 29 (a)
pxt 36
  • 29 (a)
Pxd 35
  • 28 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C46A5.4 36
  • 36 (a)
ZK430.8 36
  • 35 (a)
F09F3.5 36
  • 32 (a)
R08F11.7 36
  • 31 (a)
K10B4.1 36
  • 30 (a)
mlt-7 35
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
ManyToMany
Species where no ortholog for MPO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPO Gene

ENSEMBL:
Gene Tree for MPO (if available)
TreeFam:
Gene Tree for MPO (if available)

Paralogs for MPO Gene

Paralogs for MPO Gene

(5) SIMAP similar genes for MPO Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MPO: view

Variants for MPO Gene

Sequence variations from dbSNP and Humsavar for MPO Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs119468010 Pathogenic, Myeloperoxidase deficiency (MPOD) [MIM:254600] 58,272,835(-) AGATC(C/T)GGGAG reference, missense
rs56378716 Pathogenic, Myeloperoxidase deficiency (MPOD) [MIM:254600] 58,279,141(-) ACTCA(C/T)GTTCA reference, missense
rs762688992 A colorectal cancer sample 58,275,567(+) TCTTC(C/T)GGGCT reference, missense
rs78950939 Pathogenic, Myeloperoxidase deficiency (MPOD) [MIM:254600] 58,279,553(+) TGCGG(C/T)ATTTG reference, missense
rs119469012 Pathogenic 58,272,825(-) GCGAT(G/T)GTTTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MPO Gene

Variant ID Type Subtype PubMed ID
nsv2109 CNV deletion 18451855
nsv509663 CNV insertion 20534489
nsv517229 CNV gain+loss 19592680

Variation tolerance for MPO Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.98; 74.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPO Gene

Human Gene Mutation Database (HGMD)
MPO
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MPO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPO Gene

Disorders for MPO Gene

MalaCards: The human disease database

(115) MalaCards diseases for MPO Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myeloperoxidase deficiency
  • mpo deficiency
alzheimer disease
  • alzheimer disease, late-onset
glomerulonephritis
  • bright's disease
vasculitis
  • angiitis
churg-strauss syndrome
  • allergic granulomatosis angiitis
- elite association - COSMIC cancer census association via MalaCards
Search MPO in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PERM_HUMAN
  • Myeloperoxidase deficiency (MPOD) [MIM:254600]: A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis. {ECO:0000269 PubMed:7904599, ECO:0000269 PubMed:8142659, ECO:0000269 PubMed:8621627, ECO:0000269 PubMed:9354683, ECO:0000269 PubMed:9637725}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for MPO Gene

infections,recurrent,with disseminated candidiasis

Relevant External Links for MPO

Genetic Association Database (GAD)
MPO
Human Genome Epidemiology (HuGE) Navigator
MPO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MPO
genes like me logo Genes that share disorders with MPO: view

Publications for MPO Gene

  1. Association between myeloperoxidase polymorphisms and its plasma levels with severity of coronary artery disease. (PMID: 19651119) Wainstein R.V. … Polanczyk C.A. (Clin. Biochem. 2010) 3 22 46 64
  2. No relationship between neutrophil granulocyte activation and the myeloperoxidase gene - 129 G>A and - 463 G>A promoter polymorphisms: implications for investigations of cardiovascular disease. (PMID: 19877306) Videm V. … Olsen G.D. (Coron. Artery Dis. 2009) 3 22 46 64
  3. Myeloperoxidase genotypes and enhanced efficacy of chemotherapy for early-stage breast cancer in SWOG-8897. (PMID: 19752340) Ambrosone C.B. … Albain K.S. (J. Clin. Oncol. 2009) 3 22 46 64
  4. A myeloperoxidase promoter polymorphism is independently associated with mortality in patients with impaired left ventricular function. (PMID: 19735726) Rudolph V. … Baldus S. (Free Radic. Biol. Med. 2009) 3 22 46 64
  5. Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis. (PMID: 19731237) Nahon P. … Beaugrand M. (Hepatology 2009) 3 22 46 64

Products for MPO Gene

  • Addgene plasmids for MPO

Sources for MPO Gene

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