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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MPO Gene

protein-coding GIFtS: 71
GCID: GC17M056347

myeloperoxidase

Explore 306 diseases affiliated with
MPO via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Myeloperoxidase¹
EC 1.11.2.2³
EC 1.11.1⁸
EC 1.11.1.7⁸

External Ids:	HGNC: 7218¹	Entrez Gene: 4353²	Ensembl: ENSG00000005381⁷	OMIM: 606989⁵	UniProtKB: P05164³

Export aliases for MPO gene to outside databases

Previous GC identifers: GC17M056091 GC17M058828 GC17M056689 GC17M056821 GC17M053702 GC17M051708

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MPO:

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component

of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into

a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This

enzyme produces hypohalous acids central to the microbicidal activity of netrophils. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PERM_HUMAN, P05164

Function: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity

against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily

hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal

activity

Gene Wiki entry for MPO (Myeloperoxidase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MPO gene promoter:
NRF-2 Sp1 AML1a Msx-1 ITF-2 Tal-1beta
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MPO promoter sequence

Search SABiosciences Chromatin IP Primers for MPO

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPO

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.1 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q21.3-q23

MPO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPO gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M056347: view genomic region (about GC identifiers)

Start:	56,347,217 bp from pter	End:	56,358,296 bp from pter
Size:	11,080 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PERM_HUMAN, P05164 (See protein sequence)

Recommended Name: Myeloperoxidase precursor

Size: 745 amino acids; 83869 Da

Cofactor: Binds 1 calcium ion per monomer

Cofactor: Binds 1 heme B (iron-protoporphyrin IX) group covalently per monomer

Subunit: Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain

Subcellular location: Lysosome

6/12 PDB 3D structures from and Proteopedia for MPO (see all 12):

1CXP (3D)

1D2V (3D)

1D5L (3D)

1D7W (3D)

1DNU (3D)

1DNW (3D)

Secondary accessions: A1L4B8 Q14862 Q4PJH5 Q9UCL7

Alternative splicing: 3 isoforms: P05164-1 P05164-2 P05164-3

Explore the universe of human proteins at neXtProt for MPO: NX_P05164

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P05164

4/7 DME Specific Peptides for MPO (P05164) (see all 7)

RDGDRFW

PCFLAGD

LTSMHTL

LMFMQWGQ

MPO Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000241.1

ENSEMBL proteins:

ENSP00000225275 ENSP00000464668 ENSP00000344419

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for MPO (Myeloperoxidase/MPO)
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	OriGene Purified Protein: MPO OriGene Protein Over-expression Lysate: MPO OriGene Custom Protein Services for MPO
	GenScript Custom Purified and Recombinant Proteins Services for MPO
	Novus Biologicals MPO Proteins Novus Biologicals MPO Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for MPO
	Uscn Proteins for MPO

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	10772654
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	TAS	2829220
GO:0005739	mitochondrion	IEA	--
GO:0005764	lysosome	IEA	--

MPO for ontologies About GeneDecksing

MPO Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MPO
	R&D Systems Antibodies for MPO (Myeloperoxidase/MPO)
	Cell Signaling Technology (CST) Antibodies for MPO
	OriGene Antibodies (see all 2): MPO OriGene Custom Antibody Services for MPO
	GenScript Custom Superior Antibodies Services for MPO
	Novus Biologicals MPO Antibodies
	Abcam antibodies for MPO
	Uscn Antibodies for MPO
	ThermoFisher Antibody for MPO

Assay Products for MPO:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for MPO (Myeloperoxidase/MPO) (see all)
	GenScript Custom Assay Services for MPO
	Enzo Life Sciences assays for MPO
	Uscn ELISAs and CLIAs for MPO

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MPO for domains About GeneDecksing

3 InterPro domains/families:

IPR010255 Haem_peroxidase

IPR019791 Haem_peroxidase_animal_subgr

IPR002007 Haem_peroxidase_animal

Graphical View of Domain Structure for InterPro Entry P05164

ProtoNet protein and cluster: P05164

2 Blocks protein families:

IPB002007 Animal haem peroxidase signature

IPB010255 Haem peroxidase

UniProtKB/Swiss-Prot: PERM_HUMAN, P05164

Similarity: Belongs to the peroxidase family. XPO subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PERM_HUMAN, P05164

Function: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity

against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily

hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal

activity

Catalytic activity: Cl(-) + H(2)O(2) + H(+) = HClO + H(2)O

Catalytic activity: Cl(-) + H(2)O(2) = HOCl + 2 H(2)O

Genatlas biochemistry entry for MPO:

myeloperoxidase,formed by dimerization of hemi-MPO,78kDa,cleaved in an alpha large (59kDa) iron binding subunit and two

smaller beta subunits (13kDa),expressed in azurophilic granules of neutrophils and primary liposomes of

monocytes,involved in oxygen dependent mechanism of phagocytosis

Enzyme Numbers (IUBMB): EC 1.11.1² EC 1.11.1.7² EC 1.11.2.2¹

miRNA Products:		OriGene 3'-UTR Clone: MPO Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPO
		1 QIAGEN miScript miRNA Assays for microRNA that regulate MPO:
		hsa-miR-4326
		SwitchGear 3'UTR luciferase reporter plasmid: MPO 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPO (see all 7) OriGene shRNA RFP: MPO OriGene siRNA: MPO
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPO

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MPO

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPO (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPO OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MPO (NM_000250)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPO
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPO

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MPO
		Search LifeMap BioReagents cell lines for MPO

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPO

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003682	chromatin binding	TAS	2829220
GO:0004601	peroxidase activity	IDA	10772654
GO:0008201	heparin binding	IDA	11907569
GO:0020037	heme binding	IEA	--
GO:0046872	metal ion binding	IEA	--

MPO for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MPO:

Synthetic lethal with Ras

Animal Models:
Mouse knock-outs for MPO: Mpo^tm1Mae Mpo^tm1Lus
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mpo):

cardiovascular system	hematopoietic system	homeostasis/metabolism	immune system	mortality/aging
muscle

MPO for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Lymphocyte Signaling

Lymphocyte Signaling

1.00

Etoposide Pathway, Pharmacokinetics/Pharmacodynamics

Etoposide Pathway, Pharmacokinetics/Pharmacodynamics

1.00

Platinum Pathway, Pharmacokinetics/Pharmacodynamics

Platinum Pathway, Pharmacokinetics/Pharmacodynamics

1.00

LDL Oxidation in Atherogenesis

LDL Oxidation in Atherogenesis

1.00

Folate Metabolism

Folate Metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MPO

LDL Oxidation in Atherogenesis

1 Cell Signaling Technology (CST) Pathway for MPO

Lymphocyte Signaling

5 BioSystems Pathways for MPO

	Folate Metabolism
	Selenium Pathway
	C-MYB transcription factor network
	IL23-mediated signaling events
	amb2 Integrin signaling

3 PharmGKB Pathways for MPO

	Carbamazepine Pathway, Pharmacokinetics
	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
	Platinum Pathway, Pharmacokinetics/Pharmacodynamics

1 Kegg Pathway (Kegg details for MPO):

Phagosome

MPO for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MPO

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/42 Interacting proteins for MPO (P05164^{2, 3} ENSP00000225275⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 42)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CP	P00450³, ENSP00000264613⁴	I2D: score=2 STRING: ENSP00000264613
ATP6V1B2	P21281², ENSP00000276390⁴	MINT-4054731 STRING: ENSP00000276390
A2M	P01023²	MINT-4054731
ACTB	P60709²	MINT-4054731
ALPP	P05187²	MINT-4054731

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001878	response to yeast	IEA	--
GO:0002149	hypochlorous acid biosynthetic process	IEA	--
GO:0002679	respiratory burst involved in defense response	IEA	--
GO:0006952	defense response	TAS	8621627
GO:0006979	response to oxidative stress	TAS	2903767

MPO for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MPO for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MPO

10/14 HMDB Compounds for MPO (see all 14) About this table

Compound	Synonyms	CAS #	PubMed Ids
Carnosine	Beta-Alanyl-L-histidine (see all 14)	305-84-0	8529024
Melatonin	5-Methoxy-N-acetyltryptamine (see all 23)	73-31-4	15636586
2-Phenylacetamide	Benzeneacetamide (see all 10)	103-81-1	--
4-Coumaryl alcohol	3-(4-Hydroxyphenyl)-1-propane (see all 12)	1076-38-6	--
Calcium	Ca (see all 2)	7440-70-2	--
Cyanosulfurous acid anion	CNSu;cyanosulfurous acid	--	--
Formaldehyde	Aldeide formica (see all 16)	50-00-0	--
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--
Hydrogen peroxide	Hydrogen peroxide (see all 44)	7722-84-1	--
Hypothiocyanite	Cyanosulfoxylate;Hypothiocyanite;OSCN-Hypothiocyanite ion;N,6-didehydro-3,6-dihydro-3-methyl-Adenosine	63296-34-4	--

10/19 DrugBank Compounds for MPO (see all 19) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Propylthiouracil	Procasil (see all 15)	51-52-5	enzyme	inhibitor	17070108 6096612 2159305 2837228
Cysteamine	(2-Mercaptoethyl)amine (see all 20)	60-23-1	enzyme	substrate	2829860 8381104 2852004
Aminosalicylic Acid	4-aminosalicylic acid (see all 10)	65-49-6	enzyme	inhibitor	16614956 2563347
Cisplatin	Cis-DDP (see all 4)	15663-27-1	enzyme	inducer	14745844 19818462
Human Serum Albumin	--	9048-49-1	enzyme	substrate	16443167 16125131
Melatonin	MEL (see all 4)	73-31-4	target	inhibitor	18237195
Melatonin	MEL (see all 4)	73-31-4	enzyme	substrate inhibitor	18237195 15636586
Octreotide	Octreotida [Spanish] (see all 3)	83150-76-9	enzyme	inhibitor	10929949 11020872
Bivalirudin	--	128270-60-0	enzyme	inhibitor	18701766
Calcipotriol	--	112965-21-6	enzyme	inhibitor	12928540
Cefaclor	CCL (see all 4)	53994-73-3	enzyme	inducer	11675909

10/154 Novoseek chemical compound relationships for MPO gene (see all 154) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hocl	94.8	691	18296711 (6), 1321719 (5), 8390258 (5), 9544578 (4) (see all 99)
3-chlorotyrosine	86.4	50	18314009 (8), 15466253 (3), 19030913 (3), 9151778 (3) (see all 22)
4-aminobenzoic acid hydrazide	82.9	31	9020887 (5), 15878909 (2), 17875773 (1), 11738154 (1) (see all 14)
hobr	82.3	46	16125131 (3), 17604010 (2), 8619607 (2), 16732739 (2) (see all 16)
h2o2	79.9	617	1319066 (6), 15878909 (5), 9686606 (4), 14613914 (4) (see all 99)
chlorohydrins	77.6	6	12614844 (2), 11677044 (1), 17604010 (1), 8060981 (1) (see all 5)
monochlorodimedone	77.2	9	10984130 (2), 18475677 (1), 2155024 (1), 1656885 (1) (see all 7)
chloramines	77.1	18	8520754 (2), 8877407 (2), 15663478 (2), 11297432 (1) (see all 13)
superoxide	77	375	17381162 (8), 8751892 (5), 11368132 (4), 17159802 (4) (see all 99)
hypothiocyanite	76.5	14	9265925 (2), 11968939 (1), 9359420 (1), 8997439 (1) (see all 12)

Search CenterWatch for drugs/clinical trials and news about MPO / PERM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MPO gene:

NM_000250.1

Unigene Cluster for MPO:

Myeloperoxidase

Hs.458272 [show with all ESTs]

Unigene Representative Sequence: NM_000250

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000225275(uc002ivu.1) ENST00000577220 ENST00000578493 ENST00000581022

ENST00000580005 ENST00000340482

miRNA Products:		OriGene 3'-UTR Clone: MPO Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPO
		1 QIAGEN miScript miRNA Assays for microRNA that regulate MPO:
		hsa-miR-4326
		SwitchGear 3'UTR luciferase reporter plasmid: MPO 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPO (see all 7) OriGene shRNA RFP: MPO OriGene siRNA: MPO
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPO

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPO (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPO OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MPO (NM_000250)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPO
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPO

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPO Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MPO
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPO
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPO

Additional cDNA sequence:

BC130476.1 J02694.1 M19507.1 S56200.1 X04876.1

18 DOTS entries:

DT.313994 DT.100772871 DT.92455127 DT.95363907 DT.92416015 DT.95334510 DT.95373051 DT.70102226

DT.91923291 DT.92455128 DT.100772870 DT.100060706 DT.120927371 DT.92455106 DT.95139332 DT.100772874

DT.92455101 DT.95272085

24/271 AceView cDNA sequences (see all 271):

AI056254 BX106821 BF877356 BQ335450 BI028047 BQ335443 AJ713081 AJ712944

BI032260 AA954479 BF893744 BF899416 T28009 BQ335100 BI056476 AJ713355

NM_000250 BQ188214 M19507 S56200 J02694 BF895799 BI818989 AJ713590

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for MPO About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12
SP1:							-																-						-
SP2:																							-						-		-		-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MPO

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MPO expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTCCCCTTT

About this image

MPO expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Extraembryonic Mesoderm

Extraembryonic Capillary Plexus

Extraembryonic Angioblasts

Endothelium

Adipose

Body Subcutaneous White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MPO Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MPO

SOURCE GeneReport for Unigene cluster: Hs.458272

SABiosciences Expression via Pathway-Focused PCR Arrays including MPO (see all 8):

Oxidative Stress in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Alzheimer's Disease in human mouse rat

Drug Metabolism in human mouse rat

Antibacterial Response in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPO Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MPO
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPO
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPO

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPO

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MPO gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MPO¹	myeloperoxidase	63.95(n) 61.38(a)		417467 XM_415716.3 XP_415716.2
lizard (Anolis carolinensis)	Reptilia	-- LPO⁶	--	59(a) 52(a)	1 ↔ many possible ortholog	AAWZ02037755(870-14726) GL344475.1(242-2089)
African clawed frog (Xenopus laevis)	Amphibia	mpo-A²	myeloperoxidase, peroxidase 2'	73.67(n)		BC048774.1
zebrafish (Danio rerio)	Actinopterygii	CABZ01066780.1⁶ mpx⁶	myeloid-specific peroxidase	50(a) 39(a)	possible ortholog possible ortholog	17(3569432-3609322) 10(6807370-6814445)
worm (Caenorhabditis elegans)	Secernentea	C46A5.4³	peroxidase	36(a) (best of 5)		IV(7748401-7756132) --

ENSEMBL Gene Tree for MPO (if available)
TreeFam Gene Tree for MPO (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MPO gene

LPO² TPO² EPX² PXDNL² PXDN²

5 SIMAP similar genes for MPO using alignment to 3 protein entries: PERM_HUMAN (see all proteins):

EPX LPO TPO PXDN PXDNL

MPO for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs119468010^1,2	C,F	pathogenic	51710992(-)	`AGATCC/TGGGAG`	2	R W	mis¹		2	NA EU	5871
rs56378716^1,2	C,F,	pathogenic	51717172(-)	`ACTCAT/CGTTCA`	2	/T /M	mis¹		2	NA EU	5007
rs78950939^1,2	C,F,	pathogenic	51717584(+)	`TGCGGT/CATTTG`	2	/Y /C	mis¹		1	NA	4492
rs34626646^1,2	C,	--	51707769(-)	`ACTGTG/AGTCAC`	1	--	ds500¹		5	NS	178
rs8178427^1,2	C,	--	51707867(+)	`TCCACG/ATACGG`	1	--	ds500¹		1	NS	174
rs8178428^1,2	C,F,H,	--	51707877(+)	`GATCTC/TAAAGG`	1	--	ds500¹		10	NS EA NA	1088
rs916114^1,2	C,F,H	--	51707884(-)	`GAGTTT/CTCCTT`	1	--	ds500¹		9	NA EA NS	1122
rs35352616^1,2	C,	--	51708086(-)	`CTGGGC/TCTGTT`	1	--	ut3¹		5	NS	182
rs8073898^1,2	C,H,	--	51708252(+)	`TGCTAA/TCCAGG`	1	--	ut3¹ ese³		5	NS EA WA	526
rs34685535^1,2	C,	--	51709116(-)	`TGTTGT/AGGCTT`	1	--	int¹		5	NS	166

HapMap Linkage Disequilibrium report for MPO (56347217 - 56358296 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MPO
1 CNV: 4410
Human Gene Mutation Database (HGMD): MPO

Locus Specific Mutation Databases (LSDB): MPO

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPO

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MPO for disorders           About GeneDecksing

OMIM gene information: 606989
OMIM disorders: 254600  104300
UniProtKB/Swiss-Prot: PERM_HUMAN, P05164

Defects in MPO are the cause of myeloperoxidase deficiency (MPOD) [MIM:254600]. A disorder characterized by

decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis

20/306 diseases for MPO (see all 306): About MalaCards

lung cancer, protection against, in smokers (3) 11 lung cancer, protection against blastic plasmacytoid dendritic cell churg-strauss syndrome

mononeuritis multiplex open-angle glaucoma protein-energy malnutrition alpha 1-antitrypsin deficiency

polyarteritis nodosa spinal cord injury immune-complex glomerulonephritis chediak-higashi syndrome

natural killer cell leukemia eosinophil peroxidase deficiency toxic epidermal necrolysis extrinsic allergic alveolitis

mononeuritis disseminated intravascular coagulation primary open angle glaucoma hypersensitivity reaction type ii disease

20/28 diseases from the University of Copenhagen DISEASES database for MPO (see all 28):

Vasculitis Inflammatory bowel disease Glomerulonephritis Lung disease

Leukemia Pancreatitis Myeloid sarcoma Hypersensitivity reaction type II disease

Heart disease Leukopenia Atherosclerosis Kidney failure

Mononeuropathy Pleurisy Arthritis Peritonitis

Diarrhea Skin disease Peripheral vascular disease Periodontal disease

10/92 Novoseek disease relationships for MPO gene (see all 92) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mpo deficiency	93.3	230	1655065 (7), 7904599 (7), 7948307 (6), 10482305 (6) (see all 80)
vasculitis	86.5	359	10229138 (5), 15730737 (5), 17070108 (5), 18806928 (4) (see all 99)
wegeners granulomatosis	83.7	62	12422006 (2), 17521322 (2), 8059116 (2), 7994909 (1) (see all 41)
inflammation	79	400	18617697 (3), 19297613 (3), 8206644 (3), 2177221 (3) (see all 99)
glomerulonephritis	77.8	129	19238910 (3), 19264905 (3), 8082301 (3), 17579266 (3) (see all 73)
sarcoma granulocytic	77.4	14	9038763 (1), 15738870 (1), 17700206 (1), 11020993 (1) (see all 14)
churg-strauss syndrome	77	29	1677531 (1), 10481446 (1), 12687504 (1), 17521322 (1) (see all 20)
glomerulonephritis rapidly progressive	73.7	11	7611243 (2), 9097926 (1), 16076370 (1), 19601559 (1) (see all 7)
acute leukemia	72.9	99	19935430 (3), 9725460 (3), 8396697 (2), 17479404 (2) (see all 55)
colitis	72.7	85	9200288 (3), 17934837 (3), 7986968 (2), 8769290 (2) (see all 51)

Genatlas disease: MPO

infections,recurrent,with disseminated candidiasis

Genetic Association Database (GAD): MPO
Human Genome Epidemiology (HuGE) Navigator: MPO (210 documents)

Export disorders for MPO gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MPO gene, integrated from 9 sources (see all 3052):
(articles sorted by number of sources associating them with MPO)

Utopia: connect your pdf to the dynamic
world of online information

Melatonin is a potent inhibitor for myeloperoxidase. (PubMed id 18237195)^{1, 7, 9} Galijasevic S....Abu-Soud H.M. (2008)
Myeloperoxidase (MPO) gene mutation in hereditary MPO deficiency. (PubMed id 8142659)^{1, 2, 9} Kizaki M.... Koeffler H.P. (1994)
Biochemical and molecular characterization of hereditary myeloperoxidase deficiency. (PubMed id 9354683)^{1, 2, 9} Romano M.... Baralle F.E. (1997)
Effect of the R569W missense mutation on the biosynthesis of myeloperoxidase. (PubMed id 8621627)^{1, 2, 9} Nauseef W.... McCormick S. (1996)
Polymorphisms of tumor necrosis factor and myeloperoxidase genes in patients with chronic renal failure on peritoneal dialysis. (PubMed id 15068388)^{1, 4, 9} Buraczynska K....Ksiazek A. (2003)
Hereditary myeloperoxidase deficiency due to a missense mutation of arginine 569 to tryptophan. (PubMed id 7904599)^{1, 2, 9} Nauseef W.M.... Cogley M. (1994)
A novel form of hereditary myeloperoxidase deficiency linked to endoplasmic reticulum/proteasome degradation. (PubMed id 9637725)^{1, 2, 9} DeLeo F.R.... Nauseef W.M. (1998)
Impact of myeloperoxidase and NADPH-oxidase polymorphisms in drug-induced agranulocytosis. (PubMed id 15538122)^{1, 4, 9} Mosyagin I....Cascorbi I. (2004)
Effect of long-term hormone replacement therapy on atherosclerosis progression in postmenopausal women relates to myeloperoxidase promoter polymorphism. (PubMed id 12915675)^{1, 4, 9} Makela R....Lehtimaki T. (2003)
Myeloperoxidase genetic polymorphisms modulate human neutrophil enzyme activity: genetic determinants for atherosclerosis? (PubMed id 16289072)^{1, 4, 9} Chevrier I....Loriot M.A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4353	HGNC: 7218	AceView: MPO	Ensembl:ENSG00000005381	euGenes: HUgn4353
ECgene: MPO	Kegg: 4353	H-InvDB: MPO

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MPO	Pharmacogenomics, SNPs, Pathways
MPObase	http://bioinf.uta.fi/MPObase/
NIEHS-SNPs	http://egp.gs.washington.edu/data/mpo/
Wikipedia	http://en.wikipedia.org/wiki/Myeloperoxidase

Intellectual Property for MPO gene
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Patent Information for MPO gene:
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GeneCards and IP:
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Nephritis
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