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Aliases for MPO Gene

Aliases for MPO Gene

  • Myeloperoxidase 2 3
  • EC 1.11.1.7 63
  • EC 1.11.2.2 4
  • EC 1.11.1 63

External Ids for MPO Gene

Previous GeneCards Identifiers for MPO Gene

  • GC17M056091
  • GC17M058828
  • GC17M056689
  • GC17M056821
  • GC17M053702
  • GC17M056347
  • GC17M051708

Summaries for MPO Gene

Entrez Gene Summary for MPO Gene

  • Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]

GeneCards Summary for MPO Gene

MPO (Myeloperoxidase) is a Protein Coding gene. Diseases associated with MPO include myeloperoxidase deficiency and vasculitis. Among its related pathways are amb2 Integrin signaling and Transcriptional misregulation in cancer. GO annotations related to this gene include chromatin binding and heme binding. An important paralog of this gene is EPX.

UniProtKB/Swiss-Prot for MPO Gene

  • Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity

Gene Wiki entry for MPO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPO Gene

Genomics for MPO Gene

Regulatory Elements for MPO Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MPO Gene

Chromosome:
17
Start:
58,269,855 bp from pter
End:
58,284,313 bp from pter
Size:
14,459 bases
Orientation:
Minus strand

Genomic View for MPO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPO Gene

Proteins for MPO Gene

  • Protein details for MPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05164-PERM_HUMAN
    Recommended name:
    Myeloperoxidase
    Protein Accession:
    P05164
    Secondary Accessions:
    • A1L4B8
    • Q14862
    • Q4PJH5
    • Q9UCL7

    Protein attributes for MPO Gene

    Size:
    745 amino acids
    Molecular mass:
    83869 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per monomer.;
    Cofactor:
    Name=heme b; Xref=ChEBI:CHEBI:60344; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per monomer.;
    Quaternary structure:
    • Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain.

    Three dimensional structures from OCA and Proteopedia for MPO Gene

    Alternative splice isoforms for MPO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPO Gene

Proteomics data for MPO Gene at MOPED

Selected DME Specific Peptides for MPO Gene

Post-translational modifications for MPO Gene

  • Glycosylation at Asn 139, Asn 323, Asn 355, Asn 391, Asn 483, and Asn 729
  • Modification sites at PhosphoSitePlus

Other Protein References for MPO Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for MPO (Myeloperoxidase/MPO)
  • Cell Signaling Technology (CST) Antibodies for MPO (MPO)

Domains & Families for MPO Gene

Protein Domains for MPO Gene

Suggested Antigen Peptide Sequences for MPO Gene

Graphical View of Domain Structure for InterPro Entry

P05164

UniProtKB/Swiss-Prot:

PERM_HUMAN :
  • Belongs to the peroxidase family. XPO subfamily.
Family:
  • Belongs to the peroxidase family. XPO subfamily.
genes like me logo Genes that share domains with MPO: view

No data available for Gene Families for MPO Gene

Function for MPO Gene

Molecular function for MPO Gene

GENATLAS Biochemistry:
myeloperoxidase,formed by dimerization of hemi-MPO,78kDa,cleaved in an alpha large (59kDa) iron binding subunit and two smaller beta subunits (13kDa),expressed in azurophilic granules of neutrophils and primary liposomes of monocytes,involved in oxygen dependent mechanism of phagocytosis
UniProtKB/Swiss-Prot CatalyticActivity:
Cl(-) + H(2)O(2) + H(+) = HClO + H(2)O
UniProtKB/Swiss-Prot CatalyticActivity:
Cl(-) + H(2)O(2) = HOCl + 2 H(2)O
UniProtKB/Swiss-Prot Function:
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity

Enzyme Numbers (IUBMB) for MPO Gene

Gene Ontology (GO) - Molecular Function for MPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding TAS 2829220
GO:0004601 peroxidase activity IDA 10772654
GO:0008201 heparin binding IDA 11907569
GO:0020037 heme binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MPO: view
genes like me logo Genes that share phenotypes with MPO: view

Animal Models for MPO Gene

MGI Knock Outs for MPO:

Animal Model Products

miRNA for MPO Gene

miRTarBase miRNAs that target MPO

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPO

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MPO Gene

Localization for MPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPO Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MPO Gene COMPARTMENTS Subcellular localization image for MPO gene
Compartment Confidence
extracellular 5
lysosome 5
nucleus 5
vacuole 5
cytoskeleton 2
cytosol 2
mitochondrion 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 10772654
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IEA --
GO:0005764 lysosome TAS 8621627
GO:0030141 secretory granule IDA 11907569
genes like me logo Genes that share ontologies with MPO: view

Pathways & Interactions for MPO Gene

genes like me logo Genes that share pathways with MPO: view

PCR Array Products

Interacting Proteins for MPO Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000225275%0d%0a9606.ENSP00000264613%0d%0a9606.ENSP00000228534%0d%0a9606.ENSP00000231228%0d%0a9606.ENSP00000264818%0d%0a9606.ENSP00000321345%0d%0a
Selected Interacting proteins: P05164-PERM_HUMAN ENSP00000225275 for MPO Gene via MINT I2D STRING

Gene Ontology (GO) - Biological Process for MPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001878 response to yeast IEA --
GO:0002149 hypochlorous acid biosynthetic process IEA --
GO:0002679 respiratory burst involved in defense response IEA --
GO:0006952 defense response TAS 8621627
GO:0006979 response to oxidative stress TAS 2903767
genes like me logo Genes that share ontologies with MPO: view

No data available for SIGNOR curated interactions for MPO Gene

Drugs & Compounds for MPO Gene

(84) Drugs for MPO Gene - From: NovoSeek, HMDB, DrugBank, DGIdb, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist, Enzyme, Other 672,226
Propylthiouracil Approved Pharma Enzyme, inhibitor 6
Aminosalicylic Acid Approved Pharma Enzyme, inhibitor 24
Calcipotriol Approved Pharma Agonist, Enzyme, inhibitor 0
Cefaclor Approved Pharma Enzyme, inducer 5

(105) Additional Compounds for MPO Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Carnosine
  • b-Alanyl-L-histidine
  • b-Alanylhistidine
  • beta-Alanyl-L-histidine
  • beta-Alanylhistidine
  • Carnosine
305-84-0
Hypothiocyanite
  • Cyanosulfoxylate
  • Hypothiocyanite
  • N,6-Didehydro-3,6-dihydro-3-methyl-Adenosine
  • OSCN-Hypothiocyanite ion
63296-34-4
2-Phenylacetamide
  • (alpha-)2-Phenylacetamide
  • 2-Phenyl-Acetamide
  • alpha-Phenylacetamide
  • alpha-Toluamide
  • alpha-Toluimidic acid
103-81-1
7-Hydroxyticlopidine
  • Hydroxyticlopidine
  • M1
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with MPO: view

Transcripts for MPO Gene

Unigene Clusters for MPO Gene

Myeloperoxidase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPO

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPO Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5:

Relevant External Links for MPO Gene

GeneLoc Exon Structure for
MPO
ECgene alternative splicing isoforms for
MPO

Expression for MPO Gene

mRNA expression in normal human tissues for MPO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MPO Gene

This gene is overexpressed in Whole Blood (x38.6) and Spleen (x4.6).

Protein differential expression in normal tissues from HIPED for MPO Gene

This gene is overexpressed in Neutrophil (37.9), Monocytes (10.5), and Nasal epithelium (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MPO Gene



SOURCE GeneReport for Unigene cluster for MPO Gene Hs.458272

genes like me logo Genes that share expression patterns with MPO: view

Protein tissue co-expression partners for MPO Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MPO Gene

Orthologs for MPO Gene

This gene was present in the common ancestor of animals.

Orthologs for MPO Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MPO 35
  • 87.14 (n)
  • 86.43 (a)
MPO 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MPO 35
  • 87.53 (n)
  • 88.19 (a)
MPO 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mpo 35
  • 85.02 (n)
  • 86.45 (a)
Mpo 16
Mpo 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MPO 35
  • 99.46 (n)
  • 99.33 (a)
MPO 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MPO 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MPO 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves MPO 35
  • 64.96 (n)
  • 63.05 (a)
-- 36
  • 60 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496213 35
  • 60.9 (n)
  • 61.73 (a)
Str.11704 35
African clawed frog
(Xenopus laevis)
Amphibia mpo-A 35
zebrafish
(Danio rerio)
Actinopterygii mpx 36
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10211 37
  • 33 (a)
CG4009 37
  • 29 (a)
CG5873 37
  • 34 (a)
CG6879 37
  • 32 (a)
CG6969 37
  • 33 (a)
pxt 37
  • 29 (a)
Pxd 36
  • 28 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C46A5.4 37
  • 36 (a)
F09F3.5 37
  • 32 (a)
K10B4.1 37
  • 30 (a)
R08F11.7 37
  • 31 (a)
ZK430.8 37
  • 35 (a)
mlt-7 36
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
ManyToMany
Species with no ortholog for MPO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPO Gene

ENSEMBL:
Gene Tree for MPO (if available)
TreeFam:
Gene Tree for MPO (if available)

Paralogs for MPO Gene

Paralogs for MPO Gene

(5) SIMAP similar genes for MPO Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MPO: view

Variants for MPO Gene

Sequence variations from dbSNP and Humsavar for MPO Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2759 - 58,270,745(-) ACAAC(A/G)TCTTC reference, missense
rs916114 -- 58,269,727(+) GAGTT(C/T)TCCTT downstream-variant-500B
rs916115 -- 58,276,701(-) GATCC(A/T)GGACG intron-variant
rs916116 -- 58,276,698(-) CCTGG(A/T)CGGAC intron-variant
rs2071409 -- 58,270,869(-) TCCCC(A/C/G)TGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPO Gene

Variant ID Type Subtype PubMed ID
nsv517229 CNV Gain+Loss 19592680
nsv509663 CNV Insertion 20534489
nsv2109 CNV Loss 18451855

Variation tolerance for MPO Gene

Residual Variation Intolerance Score: 57.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.98; 74.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPO Gene

HapMap Linkage Disequilibrium report
MPO
Human Gene Mutation Database (HGMD)
MPO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPO Gene

Disorders for MPO Gene

MalaCards: The human disease database

(94) MalaCards diseases for MPO Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
myeloperoxidase deficiency
  • mpo deficiency
vasculitis
  • angiitis
myeloid sarcoma
  • chloroma
microscopic polyangiitis
  • mpa
mediastinitis
- elite association
Search MPO in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PERM_HUMAN
  • Myeloperoxidase deficiency (MPOD) [MIM:254600]: A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis. {ECO:0000269 PubMed:7904599, ECO:0000269 PubMed:8142659, ECO:0000269 PubMed:9354683, ECO:0000269 PubMed:9637725}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for MPO Gene

infections,recurrent,with disseminated candidiasis

Relevant External Links for MPO

Genetic Association Database (GAD)
MPO
Human Genome Epidemiology (HuGE) Navigator
MPO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MPO
genes like me logo Genes that share disorders with MPO: view

Publications for MPO Gene

  1. Liberation of vessel adherent myeloperoxidase by enoxaparin improves endothelial function. (PMID: 19049846) Rudolph T.K. … Baldus S. (Int. J. Cardiol. 2010) 23 25 26 67
  2. Cisplatin reduces Brucella melitensis-infected cell number by inducing apoptosis, oxidant and pro-inflammatory cytokine production. (PMID: 19818462) Erdogan S. … Celik S. (Res. Vet. Sci. 2010) 23 25 26 67
  3. Melatonin is a potent inhibitor for myeloperoxidase. (PMID: 18237195) Galijasevic S. … Abu-Soud H.M. (Biochemistry 2008) 23 25 26 67
  4. Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis. (PMID: 17070108) Zhang A.H. … Wang H.Y. (Clin. Immunol. 2007) 23 25 26 67
  5. Bivalirudin decreases NO bioavailability by vascular immobilization of myeloperoxidase. (PMID: 18701766) Rudolph V. … Baldus S. (J. Pharmacol. Exp. Ther. 2008) 23 25 67

Products for MPO Gene

Sources for MPO Gene

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