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Aliases for MPND Gene

Aliases for MPND Gene

  • MPN Domain Containing 2 3 5
  • EC 3.4.-.- 4

External Ids for MPND Gene

Previous GeneCards Identifiers for MPND Gene

  • GC19P004295
  • GC19P004105

Summaries for MPND Gene

GeneCards Summary for MPND Gene

MPND (MPN Domain Containing) is a Protein Coding gene. GO annotations related to this gene include peptidase activity. An important paralog of this gene is MYSM1.

UniProtKB/Swiss-Prot for MPND Gene

  • Probable protease.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPND Gene

Genomics for MPND Gene

Regulatory Elements for MPND Gene

Enhancers for MPND Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G003394 0.4 dbSUPER 5.3 -948.8 -948785 1.3 ZNF280D MPND AES ENSG00000279599 SMIM24
GH19G004344 0.5 ENCODE 0.7 +0.9 859 0.1 BCOR ZNF263 ZNF394 FSD1 TMIGD2 SHD CHAF1A SH3GL1 EIF1P6 MPND
GH19G004347 0.4 ENCODE 0.7 +4.0 3954 0.8 FOXM1 ZNF10 STAP2 FSD1 TMIGD2 SHD SH3GL1 CHAF1A EIF1P6 MPND
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MPND on UCSC Golden Path with GeneCards custom track

Promoters for MPND Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106191 -227 1801 HDGF PKNOX1 MLX WRNIP1 ZFP64 SIN3A ARID4B DMAP1 ZNF2 YY1

Genomic Location for MPND Gene

Chromosome:
19
Start:
4,343,527 bp from pter
End:
4,360,086 bp from pter
Size:
16,560 bases
Orientation:
Plus strand

Genomic View for MPND Gene

Genes around MPND on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPND Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPND Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPND Gene

Proteins for MPND Gene

  • Protein details for MPND Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N594-MPND_HUMAN
    Recommended name:
    MPN domain-containing protein
    Protein Accession:
    Q8N594
    Secondary Accessions:
    • Q96SJ0
    • Q9Y2P1
    • Q9Y2P2

    Protein attributes for MPND Gene

    Size:
    471 amino acids
    Molecular mass:
    50662 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MPND Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPND Gene

Post-translational modifications for MPND Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MPND Gene

Domains & Families for MPND Gene

Protein Domains for MPND Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MPND Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N594

UniProtKB/Swiss-Prot:

MPND_HUMAN :
  • The JAMM motif may mediate the protease activity.
  • Belongs to the peptidase M67 family.
Domain:
  • The JAMM motif may mediate the protease activity.
Family:
  • Belongs to the peptidase M67 family.
genes like me logo Genes that share domains with MPND: view

No data available for Gene Families for MPND Gene

Function for MPND Gene

Molecular function for MPND Gene

UniProtKB/Swiss-Prot Function:
Probable protease.

Enzyme Numbers (IUBMB) for MPND Gene

Gene Ontology (GO) - Molecular Function for MPND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MPND: view
genes like me logo Genes that share phenotypes with MPND: view

Animal Model Products

CRISPR Products

miRNA for MPND Gene

miRTarBase miRNAs that target MPND

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPND Gene

Localization for MPND Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPND gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MPND Gene

Pathways & Interactions for MPND Gene

No Data Available

Gene Ontology (GO) - Biological Process for MPND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with MPND: view

No data available for Pathways by source and SIGNOR curated interactions for MPND Gene

Drugs & Compounds for MPND Gene

No Compound Related Data Available

Transcripts for MPND Gene

Unigene Clusters for MPND Gene

MPN domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPND Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3:

Relevant External Links for MPND Gene

GeneLoc Exon Structure for
MPND
ECgene alternative splicing isoforms for
MPND

Expression for MPND Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MPND Gene

Protein differential expression in normal tissues from HIPED for MPND Gene

This gene is overexpressed in Brain (58.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MPND Gene



Protein tissue co-expression partners for MPND Gene

NURSA nuclear receptor signaling pathways regulating expression of MPND Gene:

MPND

SOURCE GeneReport for Unigene cluster for MPND Gene:

Hs.321689

Evidence on tissue expression from TISSUES for MPND Gene

  • Liver(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with MPND: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPND Gene

Orthologs for MPND Gene

This gene was present in the common ancestor of animals.

Orthologs for MPND Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MPND 34 35
  • 99 (n)
dog
(Canis familiaris)
Mammalia MPND 34 35
  • 87.94 (n)
cow
(Bos Taurus)
Mammalia MPND 34 35
  • 86.12 (n)
rat
(Rattus norvegicus)
Mammalia Mpnd 34
  • 84.67 (n)
mouse
(Mus musculus)
Mammalia Mpnd 34 16 35
  • 84.59 (n)
oppossum
(Monodelphis domestica)
Mammalia MPND 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MPND 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves MPND 34 35
  • 68.84 (n)
lizard
(Anolis carolinensis)
Reptilia MPND 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mpnd 34
  • 65.89 (n)
zebrafish
(Danio rerio)
Actinopterygii mpnd 34 35
  • 63.64 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008858 34
  • 56.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4751 35
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
Species where no ortholog for MPND was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPND Gene

ENSEMBL:
Gene Tree for MPND (if available)
TreeFam:
Gene Tree for MPND (if available)

Paralogs for MPND Gene

Paralogs for MPND Gene

genes like me logo Genes that share paralogs with MPND: view

Variants for MPND Gene

Sequence variations from dbSNP and Humsavar for MPND Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000016607 -- 4,347,490(+) CACCT(C/T)GGCCT intron-variant
rs1000088517 -- 4,347,328(+) CTCTG(C/T)CTCCC intron-variant
rs1000299437 -- 4,342,271(+) CCAAA(C/G)AGAAA upstream-variant-2KB
rs1000474617 -- 4,347,639(+) GTTAC(A/G)TTATA intron-variant
rs1000849681 -- 4,355,885(+) ATTCT(C/T)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPND Gene

Variant ID Type Subtype PubMed ID
nsv1138659 CNV deletion 24896259
nsv458328 CNV gain 19166990
nsv477244 CNV novel sequence insertion 20440878
nsv578443 CNV gain 21841781
nsv833717 CNV loss 17160897
nsv833718 CNV loss 17160897
nsv833719 CNV loss 17160897

Variation tolerance for MPND Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 58.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPND Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MPND

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPND Gene

Disorders for MPND Gene

Relevant External Links for MPND

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MPND

No disorders were found for MPND Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPND Gene

Publications for MPND Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  2. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64
  3. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for MPND Gene

Sources for MPND Gene

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