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Aliases for MPND Gene

Aliases for MPND Gene

  • MPN Domain Containing 2 3
  • EC 3.4.-.- 4

External Ids for MPND Gene

Previous GeneCards Identifiers for MPND Gene

  • GC19P004295
  • GC19P004105

Summaries for MPND Gene

GeneCards Summary for MPND Gene

MPND (MPN Domain Containing) is a Protein Coding gene. GO annotations related to this gene include peptidase activity. An important paralog of this gene is MYSM1.

UniProtKB/Swiss-Prot for MPND Gene

  • Probable protease.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPND Gene

Genomics for MPND Gene

Regulatory Elements for MPND Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MPND Gene

4,343,527 bp from pter
4,360,086 bp from pter
16,560 bases
Plus strand

Genomic View for MPND Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPND Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPND Gene

Proteins for MPND Gene

  • Protein details for MPND Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MPN domain-containing protein
    Protein Accession:
    Secondary Accessions:
    • Q96SJ0
    • Q9Y2P1
    • Q9Y2P2

    Protein attributes for MPND Gene

    471 amino acids
    Molecular mass:
    50662 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MPND Gene


neXtProt entry for MPND Gene

Proteomics data for MPND Gene at MOPED

Post-translational modifications for MPND Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for MPND Gene

Domains for MPND Gene

Protein Domains for MPND Gene


Suggested Antigen Peptide Sequences for MPND Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The JAMM motif may mediate the protease activity.
  • Belongs to the peptidase M67 family.
  • The JAMM motif may mediate the protease activity.
  • Contains 1 MPN (JAB/Mov34) domain.
  • Belongs to the peptidase M67 family.
genes like me logo Genes that share domains with MPND: view

No data available for Gene Families for MPND Gene

Function for MPND Gene

Molecular function for MPND Gene

UniProtKB/Swiss-Prot Function:
Probable protease.

Enzyme Numbers (IUBMB) for MPND Gene

Gene Ontology (GO) - Molecular Function for MPND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with MPND: view

Phenotypes for MPND Gene

genes like me logo Genes that share phenotypes with MPND: view

Animal Model Products

CRISPR Products

miRNA for MPND Gene

miRTarBase miRNAs that target MPND

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPND

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for MPND Gene

Localization for MPND Gene

Subcellular locations from

Jensen Localization Image for MPND Gene COMPARTMENTS Subcellular localization image for MPND gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MPND Gene

Pathways for MPND Gene

SuperPathways for MPND Gene

No Data Available

Gene Ontology (GO) - Biological Process for MPND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with MPND: view

No data available for Pathways by source for MPND Gene

Transcripts for MPND Gene

Unigene Clusters for MPND Gene

MPN domain containing:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPND

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPND Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -

Relevant External Links for MPND Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPND Gene

mRNA expression in normal human tissues for MPND Gene

Protein differential expression in normal tissues for MPND Gene

This gene is overexpressed in Brain (58.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPND Gene

SOURCE GeneReport for Unigene cluster for MPND Gene Hs.321689

genes like me logo Genes that share expressions with MPND: view

Expression partners for MPND Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MPND Gene

Orthologs for MPND Gene

This gene was present in the common ancestor of animals.

Orthologs for MPND Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MPND 35
  • 86.12 (n)
  • 87.2 (a)
  • 82 (a)
(Canis familiaris)
Mammalia MPND 35
  • 87.94 (n)
  • 90.43 (a)
  • 83 (a)
(Mus musculus)
Mammalia Mpnd 35
  • 84.59 (n)
  • 87.19 (a)
Mpnd 16
Mpnd 36
  • 77 (a)
(Pan troglodytes)
Mammalia MPND 35
  • 99 (n)
  • 99.18 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Mpnd 35
  • 84.67 (n)
  • 87.44 (a)
(Monodelphis domestica)
Mammalia MPND 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia MPND 36
  • 65 (a)
(Gallus gallus)
Aves MPND 35
  • 68.84 (n)
  • 65.28 (a)
  • 60 (a)
(Anolis carolinensis)
Reptilia MPND 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mpnd 35
  • 65.89 (n)
  • 69.77 (a)
(Danio rerio)
Actinopterygii mpnd 35
  • 63.64 (n)
  • 64.25 (a)
mpnd 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008858 35
  • 56.48 (n)
  • 45.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4751 36
  • 5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
-- 36
  • 32 (a)
Species with no ortholog for MPND:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPND Gene

Gene Tree for MPND (if available)
Gene Tree for MPND (if available)

Paralogs for MPND Gene

Paralogs for MPND Gene

genes like me logo Genes that share paralogs with MPND: view

Variants for MPND Gene

Sequence variations from dbSNP and Humsavar for MPND Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs116344921 -- 4,350,975(+) ACCGT(C/G)TCCTG intron-variant
rs56942202 -- 4,355,458(+) AGCCT(A/C)CTGAA intron-variant
rs56828298 -- 4,352,376(+) TGCGC(A/C)GGGCT intron-variant
rs56812200 -- 4,350,118(+) TGAAC(A/G)GAGAA intron-variant
rs56331661 -- 4,355,870(+) TTTTT(-/TT)CTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPND Gene

Variant ID Type Subtype PubMed ID
nsv910817 CNV Loss 21882294
nsv833717 CNV Loss 17160897
nsv833718 CNV Loss 17160897
nsv910820 CNV Gain 21882294
dgv3674n71 CNV Loss 21882294
dgv3675n71 CNV Loss 21882294
nsv910824 CNV Gain 21882294
nsv458328 CNV Gain 19166990
nsv833719 CNV Loss 17160897
nsv910827 CNV Loss 21882294

Relevant External Links for MPND Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPND Gene

Disorders for MPND Gene

No disorders were found for MPND Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MPND Gene

Publications for MPND Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for MPND Gene

Sources for MPND Gene

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