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MPND Gene

protein-coding   GIFtS: 45
GCID: GC19P004343

MPN Domain Containing

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MPN Domain Containing1 2
MPN Domain-Containing Protein2
EC 3.4.-.-3

External Ids:    HGNC: 259341   Entrez Gene: 849542   Ensembl: ENSG000000083827   UniProtKB: Q8N5943   

Export aliases for MPND gene to outside databases

Previous GC identifers: GC19P004295 GC19P004105


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MPND Gene:
MPND (MPN domain containing) is a protein-coding gene. GO annotations related to this gene include peptidase activity. An important paralog of this gene is MYSM1.

UniProtKB/Swiss-Prot: MPND_HUMAN, Q8N594
Function: Probable protease (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MPND gene promoter:
         SREBP-1a   SREBP-1c   STAT3   STAT5A   NF-kappaB   NF-kappaB1   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMPND promoter sequence
   Search Chromatin IP Primers for MPND

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MPND


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

MPND Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPND gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P004343:  view genomic region     (about GC identifiers)

Start:
4,343,524 bp from pter      End:
4,360,083 bp from pter
Size:
16,560 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MPND_HUMAN, Q8N594 (See protein sequence)
Recommended Name: MPN domain-containing protein  
Size: 471 amino acids; 50662 Da
Secondary accessions: Q96SJ0 Q9Y2P1 Q9Y2P2
Alternative splicing: 2 isoforms:  Q8N594-1   Q8N594-2   

Explore the universe of human proteins at neXtProt for MPND: NX_Q8N594

Explore proteomics data for MPND at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MPND Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001153318.1  NP_116257.2  

    ENSEMBL proteins: 
     ENSP00000262966   ENSP00000353015   ENSP00000471735   ENSP00000470987   ENSP00000471715  
     ENSP00000471189   ENSP00000469230   ENSP00000469057  

    MPND Human Recombinant Protein Products:

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    Novus Biologicals MPND Proteins
    Novus Biologicals MPND Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MPND

     
    Search eBioscience for Proteins for MPND 

     
    antibodies-online proteins for MPND (5 products) 

     
    antibodies-online peptides for MPND

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    LSBio Antibodies in human, mouse, rat for MPND
    antibodies-online antibodies for MPND (22 products) 

    MPND Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MPND
    Cloud-Clone Corp. CLIAs for MPND
    Search eBioscience for ELISAs for MPND 
    antibodies-online kits for MPND (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000555 JAB_MPN_dom

    Graphical View of Domain Structure for InterPro Entry Q8N594

    ProtoNet protein and cluster: Q8N594

    1 Blocks protein domain: IPB000555 Mov34 family

    UniProtKB/Swiss-Prot: MPND_HUMAN, Q8N594
    Domain: The JAMM motif may mediate the protease activity (By similarity)
    Similarity: Belongs to the peptidase M67 family
    Similarity: Contains 1 MPN (JAB/Mov34) domain


    Find genes that share domains with MPND           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPND_HUMAN, Q8N594
    Function: Probable protease (By similarity)

         Enzyme Number (IUBMB): EC 3.4.-.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008233peptidase activity IEA--
         
    Find genes that share ontologies with MPND           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MPND:
     Decreased circadian period len  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MPND
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MPND
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MPND

    miRNA
    Products:
        
    miRTarBase miRNAs that target MPND:
    hsa-let-7b-5p (MIRT052090), hsa-mir-335-5p (MIRT018667)

    Block miRNA regulation of human, mouse, rat MPND using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MPND
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MPND

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MPND (NM_032868)
    Sino Biological Human cDNA Clone for MPND
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPND
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPND

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPND


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MPND
    Interactions:

        Search GeneGlobe Interaction Network for MPND

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MPND (Q8N5943 ENSP000002629664) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP30Q70CQ33, ENSP000002575484I2D: score=1 STRING: ENSP00000257548
    USP36Q9P2753, ENSP000003105904I2D: score=2 STRING: ENSP00000310590
    KIAA0368ENSP000002593354STRING: ENSP00000259335
    PSMA4ENSP000000444624STRING: ENSP00000044462
    PSMA5ENSP000002713084STRING: ENSP00000271308
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with MPND           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MPND



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MPND gene (2 alternative transcripts): 
    NM_001159846.1  NM_032868.4  

    Unigene Cluster for MPND:

    MPN domain containing
    Hs.321689  [show with all ESTs]
    Unigene Representative Sequence: NM_032868
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262966(uc010dtx.2 uc002mae.3) ENST00000359935(uc002mag.3)
    ENST00000599840 ENST00000594716 ENST00000596722 ENST00000597036 ENST00000601877
    ENST00000594162
    miRNA
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    Block miRNA regulation of human, mouse, rat MPND using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MPND
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MPND
    Predesigned siRNA for gene silencing in human, mouse, rat MPND
    Clone
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    OriGene clones in human, mouse for MPND (see all 13)
    OriGene ORF clones in mouse, rat for MPND
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MPND (NM_032868)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPND
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPND
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MPND
    OriGene qSTAR qPCR primer pairs in human, mouse for MPND
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MPND
      QuantiTect SYBR Green Assays in human, mouse, rat MPND
      QuantiFast Probe-based Assays in human, mouse, rat MPND

    Additional mRNA sequence: 

    AK027887.1 AK308468.1 BC032652.1 

    10 DOTS entries:

    DT.75125944  DT.75102001  DT.100760163  DT.100777587  DT.100760119  DT.100777592  DT.100777588  DT.100777589 
    DT.92449455  DT.40272258 

    Selected AceView cDNA sequences (see all 98):

    F27272 CR610197 CR613172 CR605933 BU732307 CR600604 BE466766 CR618730 
    BU150675 BE048147 AA402556 AA228985 AI337143 BE463545 NM_032868 AL540282 
    AW628071 AW611881 BX094516 AW594270 BX391805 BG764890 BE671216 AA905038 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MPND    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                              -               
    SP2:                                      -     -                                 
    SP3:                                                                              


    ECgene alternative splicing isoforms for MPND

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MPND expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGTGGAGA
    MPND Expression
    About this image

    MPND Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MPND Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.321689
        Custom PCR Arrays for MPND
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPND

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MPND gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mpnd1 , 5 MPN domain containing1, 5 84.59(n)1
    87.19(a)1
      17 (29.11 cM)5
    680471  NM_026530.51  NP_080806.41 
     560057115 
    chicken
    (Gallus gallus)
    Aves MPND1 MPN domain containing 68.84(n)
    65.28(a)
      100858729  XM_003642850.2  XP_003642898.2 
    lizard
    (Anolis carolinensis)
    Reptilia MPND6
    MPN domain containing
    53(a)
    1 ↔ 1
    GL343531.1(915-4333)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mpnd1 MPN domain containing 65.89(n)
    69.77(a)
      100125058  NM_001102976.1  NP_001096446.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mpnd1 MPN domain containing 63.64(n)
    64.25(a)
      559169  NM_001076565.1  NP_001070033.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG47516
    --
    5(a)
    1 → many
    2L(11130741-11136003)


    ENSEMBL Gene Tree for MPND (if available)
    TreeFam Gene Tree for MPND (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MPND gene
    MYSM12  

    Find genes that share paralogs with MPND           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MPND (see all 488)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs735372211,2
    C--4341584(+) CAGGCG/ATGCTG 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1445759051,2
    C--4341703(+) GGAGAC/TAGAGC 2 -- us2k10--------
    rs1481720401,2
    C--4341722(+) GTCTCA/GAAAAG 2 -- us2k10--------
    rs729867801,2
    C,F--4341747(+) TGGGCG/ACAGTG 2 -- us2k15Minor allele frequency- A:0.50WA NA CSA 10
    rs23866011,2
    C,F,A--4341899(+) ATCTGC/TAGTCC 2 -- us2k16Minor allele frequency- T:0.32NA WA CSA 129
    rs1150793961,2
    C,F--4342253(+) GGGACG/AGAAAA 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1506701241,2
    C--4342254(+) GGACGA/G/TAAAAA 2 -- us2k10--------
    rs44353811,2
    C,F,A,H--4342285(+) AAGGAC/GTTGGG 2 -- us2k118Minor allele frequency- N:0.00NS EA NA WA CSA 1007
    rs169923601,2
    C,F--4342329(+) GTCTGC/GAGGCC 2 -- us2k17Minor allele frequency- G:0.04NA WA CSA EA 381
    rs743185431,2
    F--4342488(+) CCGCAC/ACCCTA 2 -- us2k12Minor allele frequency- A:0.05WA NA 238

    HapMap Linkage Disequilibrium report for MPND (4343524 - 4360083 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for MPND:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv910827CNV Loss21882294
    dgv3675n71CNV Loss21882294
    dgv3674n71CNV Loss21882294
    nsv833717CNV Loss17160897
    nsv833718CNV Loss17160897
    nsv910817CNV Loss21882294
    nsv833719CNV Loss17160897
    nsv458328CNV Gain19166990
    nsv910820CNV Gain21882294
    nsv910824CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MPND
    DNA2.0 Custom Variant and Variant Library Synthesis for MPND

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MPND gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MPND)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    2. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (Cell 2006)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84954 HGNC: 25934 AceView: FLJ14981 Ensembl:ENSG00000008382 euGenes: HUgn84954
    ECgene: MPND H-InvDB: MPND

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MPND Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MPND gene:
    Search GeneIP for patents involving MPND

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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