MPLKIP Gene
protein-coding GIFtS: 41
GCID: GC07M040172
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|
M-phase specific PLK1 interacting protein(Previous name: chromosome 7 open reading frame 11 )
(Previous symbol: C7orf11)
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Aliases
for MPLKIP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| M-Phase Specific PLK1 Interacting Protein1 2 | | ABHS2 5 | | C7orf111 2 3 5 | | Chromosome 7 Open Reading Frame 111 | | TTDN11 3 5 | | M-Phase-Specific PLK1-Interacting Protein2 | | ORF201 2 | | Russell-Silver Syndrome Region2 | | TTD Non-Photosensitive 1 Protein2 3 | | |
Export aliases for MPLKIP gene to outside databases |
Summaries
for MPLKIP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MPLKIP:
The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. Theprotein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result innonphotosensitive trichothiodystrophy. (provided by RefSeq, Nov 2009)
UniProtKB/Swiss-Prot: MPLKI_HUMAN, Q8TAP9Function: May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis
Gene Wiki entry for MPLKIP (C7orf11)
|
Genomic Views
for MPLKIP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MPLKIP
Other transcription factors
Search SABiosciences Chromatin IP Primers for MPLKIP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPLKIP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p14.1 Ensembl cytogenetic band: 7p14.1 HGNC cytogenetic band: 7p14MPLKIP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M040172: view genomic region
(about GC identifiers)
Start:
|
40,172,342 bp from pter |
End:
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40,174,258 bp from pter |
Size:
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1,917 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 40,210,771-40,212,680 |
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Proteins
for MPLKIP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MPLKI_HUMAN, Q8TAP9 (See
protein sequence)Recommended Name: M-phase-specific PLK1-interacting protein Size: 179 amino acids; 19147 Da
Subunit: Interacts with PLK1; phosphorylation-dependent
Subcellular location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Note=The subcellular location isregulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome anddispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in MphaseExplore the universe of human proteins at neXtProt for MPLKIP: NX_Q8TAP9
Post-translational modifications:
Phosphorylated during mitosis in the cell cycle probably by CDK11
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TAP9
MPLKIP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_619646.1
ENSEMBL proteins: ENSP00000304553
Human Recombinant Protein Products for MPLKIP:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MPLKIP for ontologies About GeneDecksing
MPLKIP Antibody Products:
Assay Products for MPLKIP: |
Protein
Domains /
Families
for MPLKIP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MPLKIP for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TAP9ProtoNet protein and cluster: Q8TAP9 |
Function
for MPLKIP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MPLKI_HUMAN, Q8TAP9Function: May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
MPLKIP for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for MPLKIP:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPLKIP
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Synthesis Service for MPLKIP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPLKIP |
|
Pathways & Interactions
for MPLKIP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MPLKIP
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
MPLKIP for ontologies About GeneDecksing
|
Drugs & Compounds
for MPLKIP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MPLKIP
Search CenterWatch for drugs/clinical trials and news about MPLKIP / MPLKI
|
Transcripts
for MPLKIP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MPLKIP gene: NM_138701.3 Unigene Cluster for MPLKIP: M-phase specific PLK1 interacting protein Hs.654989 [show with all ESTs]Unigene Representative Sequence: BQ8988321 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000306984(uc003thl.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPLKIP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPLKIP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for MPLKIP | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MPLKIP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPLKIP |
Additional cDNA sequence: AK290098.1 BC026265.1 5 DOTS entries: DT.445061 DT.100817216 DT.101983107 DT.95372919 DT.452086 24/133 AceView cDNA sequences (see all 133): AI583177 CF126987 AI911267 AW955632 CF128816 CB218885 AI672601 BX281428 AW073942 CF593269 BC026265 CB995348 BQ271192 AA988650 AI243358 AI867079 AW630101 BP378330 CA310385 CR594841 AW166798 BQ081845 AA587686 AA913666
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for MPLKIP About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b |
|---|
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| SP1: | | | | | | | | | | | |
| SP2: | | | | | - | | | | | |
ECgene alternative splicing isoforms for MPLKIP
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Expression
for MPLKIP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MPLKIP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTCAGGAAC
About this image
See MPLKIP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MPLKIP
SOURCE GeneReport for Unigene cluster: Hs.654989
UniProtKB/Swiss-Prot: MPLKI_HUMAN, Q8TAP9Tissue specificity: Expressed at highest levels in liver and kidney; intermediate expression in skeletal muscle,pancreas, heart and placenta; low expression in brain and lung. Expressed in epidermis and hair follicles
SABiosciences Custom PCR Arrays for MPLKIP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPLKIP
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MPLKIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPLKIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPLKIP |
Orthologs
for MPLKIP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MPLKIP gene from 5/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mplkip1 , 5 |
RIKEN cDNA 2810021B07 gene5
M-phase specific PLK1 intereacting protein1 |
91.71(n)1
89.27(a)1 |
|
13 (6.05 cM)5
663081 NM_025479.51 NP_079755.11
176954135 |
chicken
(Gallus gallus) |
Aves |
MPLKIP1 |
M-phase specific PLK1 interacting protein |
70.44(n)
73.21(a) |
|
776599 XM_001236112.2 XP_001236113.2 |
lizard
(Anolis carolinensis) |
Reptilia |
C7orf116 |
-- |
56(a) |
1 ↔ 1 |
6(48917705-48921968) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.290952 |
Xenopus laevis transcribed sequence with weak similarity more |
79.21(n) |
|
BJ030862.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC062385.12 |
-- |
80(n) |
|
BC062385.1 |
ENSEMBL Gene Tree for MPLKIP (if available)
TreeFam Gene Tree for MPLKIP (if available) |
Paralogs
for MPLKIP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MPLKIP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MPLKIP (40172342 - 40174258 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MPLKIP: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPLKIP |
|
Disorders
/ Diseases
for MPLKIP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MPLKIP for disorders About GeneDecksing
OMIM gene information: 609188
OMIM disorders: 234050
UniProtKB/Swiss-Prot: MPLKI_HUMAN, Q8TAP9
Defects in MPLKIP are a cause of trichothiodystrophy non-photosensitive type 1 (TTDN1) [MIM:234050]; alsoknown as Amish brittle hair brain syndrome (ABHS), hair-brain syndrome and BIDS syndrome. TTDN1 is an autosomalrecessive disorder characterized by short stature, intellectual impairment, sulfur-deficient brittle hair anddecreased male fertility but not cutaneous photosensitivity
3  diseases for MPLKIP: About MalaCardstrichothiodystrophy, nonphotosensitive 1 nonphotosensitive trichothiodystrophy short stature
Export disorders for MPLKIP gene to outside databases
|
Publications
for MPLKIP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MPLKIP gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with MPLKIP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular genetic studies of human chromosome 7 in Russell-Silver syndrome. (PubMed id 11829489)1, 2, 3 Nakabayashi K.... Scherer S.W. (2002)
- Identification of C7orf11 (TTDN1) gene mutations and genetic heterogeneity in nonphotosensitive trichothiodystrophy. (PubMed id 15645389)1, 2, 9 Nakabayashi K....Scherer S.W. (2005)
- TTDN1 is a Plk1-interacting protein involved in maintenance of cell cycle integrity. (PubMed id 17310276)1, 2 Zhang Y....Shu H.B. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mutations in the C7orf11 (TTDN1) gene in six nonphotosensitive trichothiodystrophy patients: no obvious genotype-phenotype relationships. (PubMed id 16977596)1, 9 Botta E....Stefanini M. (2007)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
|
External Searches for MPLKIP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MPLKIP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MPLKIP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MPLKIP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MPLKIP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MPLKIP gene:
Search GeneIP for patents involving MPLKIP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MPLKIP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MPLKIP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPLKIP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPLKIP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPLKIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPLKIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPLKIP |
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 | | | MPLKIP Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for MPLKIP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPLKIP |
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