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MPL Gene

protein-coding GIFtS: 68

GC01P043576

myeloproliferative leukemia virus oncogene
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
C-MPL ^²
C-mpl ^³
CD110 ^¹, ²
MPLV ^², ⁵
OTTHUMP00000008582 ^²
TPO-R ^³
TPOR ^², ³, ⁵

Descriptions
CD110 antigen ^³
Myeloproliferative leukemia protein ^³
myeloproliferative leukemia virus oncogene ^²
thrombopoietin receptor ^²

External Ids
HGNC: 7217¹
Entrez Gene: 4352²
UniProtKB: P40238³
Ensembl: ENSG00000117400⁷

Search outside databases for aliases for MPL gene

Previous GC identifers: GC01P043746 GC01P042803 GC01P043233 GC01P043216 GC01P043472

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MPL:

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that

was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the

human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein

that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense

oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl,

thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of

megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a

635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two

intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic,

emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet

formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor

tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the

receptors themselves become tyrosine phosphorylated. [provided by RefSeq]

UniProtKB/Swiss-Prot: TPOR_HUMAN, P40238

Function: Receptor for thrombopoietin. May represent a regulatory molecule specific for

TPO-R-dependent immune responses

Gene Wiki entry for MPL (Myeloproliferative_leukemia_virus_oncogene)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MPL gene

Entrez Gene cytogenetic band: 1p34 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34

MPL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P043576: (about GC identifiers)

Start:	43,576,062 bp from pter
End:	43,592,722 bp from pter
Size:	16,661 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TPOR_HUMAN, P40238 (See protein sequence)

Recommended Name: Thrombopoietin receptor precursor

Size: 635 amino acids; 71245 Da

Subunit: Interacts with ATXN2L

Subcellular location: Membrane; Single-pass type I membrane protein

Caution: It is uncertain whether Met-1 or Met-8 is the initiator

Alternative splicing: 2 isoforms: P40238-1 P40238-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005364.1

ENSEMBL proteins:

ENSP00000361546 ENSP00000361548

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for MPL (Thrombopoietin R)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TPOR)
	Human Recombinant Proteins from Abnova (MPL)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IDA	18029348
GO:0005887	integral to plasma membrane	TAS	8020956

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Antibodies for MPL:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of MPL
	Sigma-Aldrich Antibodies for MPL
	R&D Systems Antibodies for MPL (Thrombopoietin R)
	Antibodies from Abcam (TPOR), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MPL)
	Novus Biologicals Antibodies for MPL

Assays for MPL:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P40238

ProtoNet protein and cluster: P40238

UniProtKB/Swiss-Prot: TPOR_HUMAN, P40238

Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient

intracellular transport and cell-surface receptor binding

Domain: The box 1 motif is required for JAK interaction and/or activation

Similarity: Belongs to the type I cytokine receptor family. Type 1 subfamily

Similarity: Contains 2 fibronectin type-III domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MPL)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MPL)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005373

Applied Biosystems Silencer® siRNAs for MPL

Sigma-Aldrich siRNA and siRNA Panels for MPL

Sigma-Aldrich shRNA Panels and shRNA for MPL

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005373
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005373
untagged cDNA clone in CMV expression vector: NM_005373

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005373

UniProtKB/Swiss-Prot: TPOR_HUMAN, P40238

Function: Receptor for thrombopoietin. May represent a regulatory molecule specific for

TPO-R-dependent immune responses

Genatlas biochemistry entry for MPL:

myeloproliferative leukemia virus oncogene homolog,hematopoietic growth factor receptor superfamily

7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Mpl):

embryogenesis	growth/size	hematopoietic system	homeostasis/metabolism	immune system
lethality-postnatal	lethality-prenatal/perinatal

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004896	cytokine receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for MPL (Your Favorite Gene powered by Ingenuity)

Thrombopoietin Signaling

GeneDecks MPL for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for MPL

5/63 Interacting proteins for MPL (ENSP00000361548³) via UniProtKB, MINT, and/or STRING (see all 63 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
THPO	ENSP00000204615³	STRING (score=.999)
JAK2	ENSP00000371067³	STRING (score=.998)
SHC1	ENSP00000357432³	STRING (score=.989)
SOCS1	ENSP00000329418³	STRING (score=.988)
NUDC	ENSP00000319664³	STRING (score=.966)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007166	cell surface receptor linked signal transduction	TAS	8020956
GO:0008283	cell proliferation	TAS	8020956

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for MPL:

Agonist

Browse Tocris compounds for MPL
10/13 Novoseek chemical compound relationships for MPL gene (see all 13 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
megapoietin	86.24	2	9154314 (1), 11012231 (1)
tyrosine	53.17	39	10224114 (3), 8555464 (2), 8695851 (2), 9600081 (2) (see all 26)
reticulin	48.44	1	16834459 (1)
gp 130	29.30	6	9685167 (2), 10068651 (2), 9389693 (1)
adp	26.77	1	15863506 (1)
thromboxane	13.14	2	8639835 (1)
phosphatidylinositol	10.28	1	11418622 (1)
lysine	0.00	1	10671297 (1)
iron	0.00	1	14608207 (1)
threonine	0.00	3	10581000 (1), 10918061 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MPL)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MPL)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005373

Sigma-Aldrich siRNA and siRNA Panels for MPL

Sigma-Aldrich shRNA Panels and shRNA for MPL

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005373

REFSEQ mRNAs for MPL gene:

NM_005373.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005373

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005373
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005373
                                 untagged cDNA clone in CMV expression vector: NM_005373

Additional cDNA sequence:

DQ234353.1 M90102.1 M90103.1

2 DOTS entries:

DT.95203663 DT.407014

4 AceView cDNA sequences:

M90102 BV196940 M90103 NM_005373

highest scoring ESTs for MPL:

M90102 M90103 NM_005373 AI702813 BP302904 DQ234353 AW016391 BE167639 R10380 U68162

Unigene Cluster for MPL:

Myeloproliferative leukemia virus oncogene

Hs.82906 [show with all ESTs]

Unigene Representative Sequence: NM_005373

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for MPL

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12
SP1:																							-
SP2:			-																				-
SP3:

About this scheme

ECgene alternative splicing isoforms for MPL

2 Ensembl transcripts including schematic representations:

ENST00000372468 ENST00000372470

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MPL expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MPL

¹ / ² / ³

7 probe-sets matching MPL gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34004_at²^{, 3}	U95-A	1	0.50	1.00	1.00	1.00	U68162	0.20	1.00	0.72	1
211903_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M90103	0.60	1.00	0.82	1
216825_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
207550_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005373	0.60	1.00	0.82	1
211903_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216825_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207550_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATAGTAGGCC

SOURCE GeneReport for Unigene cluster: Hs.82906
Expression variation in blood from EXPOLDB for MPL
UniProtKB/Swiss-Prot: TPOR_HUMAN, P40238
Tissue specificity: Expressed at a low level in a large number of cells of hematopoietic origin.
Isoform 1 and isoform 2 are always found to be coexpressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MPL gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	MPL¹	--	myeloproliferative leukemia virus oncogene	99.69(n) 99.69(a)	747522 XM_001173359.1 XP_001173359.1
cow (Bos taurus)	MPL¹	--	myeloproliferative leukemia virus oncogene	86.78(n) 81.99(a)	528492 XM_606917.3 XP_606917.3
rat (Rattus norvegicus)	Mpl¹	--	myeloproliferative leukemia virus oncogene	83.23(n) 77.71(a)	366455 XM_345572.3 XP_345573.3
mouse (Mus musculus)	Mpl^{1, 5}	4 (56.50 cM)⁵	myeloproliferative leukemia virus oncogene^{1, 5}	85.28(n)¹ 81.76(a)¹	17480¹ NM_010823.1¹ NP_034953.1¹ AF360122⁵ AK041166⁵ (see all 17)
chicken (Gallus gallus)	MPL¹	--	myeloproliferative leukemia virus oncogene	52.08(n) 41.18(a)	414804 NM_001001782.1 NP_001001782.1

About this table Species with no ortholog for MPL

ENSEMBL Gene Tree for MPL

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MPL gene

EPOR²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/79 NCBI SNPs in MPL are shown (see all 79 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 37)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs710252^1,2	A,C,F,H,O	43575809(+)	`TAATCG/ATTAGC`	1	--	ng5¹		11	EU EA WA NA	978
	rs839993^1,2	A,C,F,H	43575707(+)	`ttgtgC/Aggatt`	1	--	ng5¹		8	EU EA WA NA	556
	rs6087^1,2	C,F,H	43576450(+)	`GGCAGC/TGCCCA`	1	A/V	mis¹		10	MN EU EA WA	1114
	rs12731981^1,2	C,F,H	43576927(+)	`AGAATG/ATGTTC`	1	M/V	mis¹		9	EU EA WA NA	906
	rs17292650^1,2	C,F	43576394(+)	`CTGAAG/TTGTTT`	1	K/N	mis¹ ese³		5	NA EU EA WA	498
	rs6689207^1,2	H	43592250(+)	`cataaC/Tttaat`	1	--	ut3¹		4	EU EA WA	414
	rs6088^1,2	H	43577639(+)	`GGTACG/AAACTC`	1	K/E	mis¹ ese³		6	MN EU EA WA	704
	rs3820551^1,2	H	43590518(+)	`GCACCG/AGGTCC`	1	Q/R	mis¹ ese³		4	EU EA WA	414
	rs16830693^1,2	C,F	43577827(+)	`AGAGAA/GGTATG`	1	E/E	syn¹		4	NA	156
	rs17572791^1,2	C,F	43577680(+)	`ACTGGT/CCCCAC`	1	G/G	syn¹ ese³		4	NA	204

About this table

HapMap Linkage Disequilibrium images for MPL (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 159530 disorders: 604498 187950 187950

UniProtKB/Swiss-Prot: TPOR_HUMAN, P40238

Defects in MPL are a cause of congenital amegakaryocytic thrombocytopenia (CAMT)

[MIM:604498]. CAMT is a disease characterized by isolated thrombocytopenia and megakaryocytopenia

with no physical anomalies

10/53 Novoseek disease relationships for MPL gene (see all 53 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
amegakaryocytic thrombocytopenia, congenital	96.15	23	19302922 (3), 16413394 (1), 10077649 (1), 10971406 (1) (see all 16)
thrombocytosis	86.32	45	19036112 (4), 10520034 (2), 15269348 (2), 17920755 (2) (see all 25)
thrombocythemia essential	86.30	13	12010817 (2), 15390356 (2), 9864154 (1), 14764528 (1) (see all 11)
polycythemia vera	84.85	20	10887148 (2), 9475764 (2), 17956691 (2), 10515857 (2) (see all 11)
myeloproliferative disorders	83.59	31	15095485 (3), 8589367 (2), 17693582 (2), 15899890 (1) (see all 18)
megakaryocytic hypoplasia	83.28	5	12209520 (2), 12794833 (1)
primary myelofibrosis	82.50	2	8589367 (1), 19194467 (1)
thrombocytopenia	79.96	66	10049050 (2), 12209520 (2), 12794833 (2), 9209831 (2) (see all 39)
idiopathic myelofibrosis	77.05	4	9864154 (1), 17920755 (1), 15095485 (1), 19194467 (1)
myelofibrosis	74.76	6	11012187 (1), 9592015 (1), 17920755 (1), 17408465 (1) (see all 6)

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Human Gene Mutation Database: MPL
Genetic Association Database: MPL
Human Genome Epidemiology Navigator: MPL (14 documents)
Tumor Gene Database: MPL

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/387 PubMed articles for MPL gene (see all 387 ):

Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. (PubMed id 1608974)^{2, 3, 4} Vigon I.... Souyri M. (1992)
Mpl Baltimore: a thrombopoietin receptor polymorphism associated with thrombocytosis. (PubMed id 15269348)^{1, 3, 6} Moliterno A.R....Spivak J.L. (2004)
Association of single nucleotide polymorphisms in the thrombopoietin-receptor gene, but not the thrombopoietin gene, with differences in platelet count. (PubMed id 15307100)^{1, 3, 6} Zeng S.M....Yankowitz J. (2004)
Structure and transcription of the human c-mpl gene (MPL). (PubMed id 8020956)^{1, 3, 4} Mignotte V.... Chretien S. (1994)
Cloning and characterization of a family of proteins associated with Mpl. (PubMed id 11784712)^{3, 4} Meunier C.F....Courtois G. (2002)
Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)^{3, 4} Cargill M....Lander E.S. (1999)
AML1/RUNX1 works as a negative regulator of c-Mpl in hematopoietic stem cells. (PubMed id 18687690)^{1, 3} Satoh Y....Kanakura Y. (2008)
Targeting c-Mpl for revival of human immunodeficiency virus type 1-induced hematopoietic inhibition when CD34+ progenitor cells are re-engrafted into a fresh stromal microenvironment in vivo. (PubMed id 15452260)^{1, 3} Koka P.S....Reddy S.T. (2004)
Janus kinases affect thrombopoietin receptor cell surface localization and stability. (PubMed id 15899890)^{1, 3} Royer Y....Constantinescu S.N. (2005)
A structure-function analysis of serine/threonine phosphorylation of the thrombopoietin receptor, c-Mpl. (PubMed id 10918061)^{1, 3} Miyakawa Y....Kaushansky K. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4352	HGNC: 7217	AceView: MPL	Ensembl:ENSG00000117400	euGenes: HUgn4352
ECgene: MPL	H-InvDB: MPL

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MPL	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=MPL

Licensable Technologies for MPL
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MPL:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MPL-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MPL		Antibodies for MPL
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MPL		Small molecules for MPL
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MPL)
	Antibodies (MPL)
	Chimera RNAi (MPL)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (TPOR)
	Antibodies (TPOR)

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Search Tocris compounds for MPL

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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MPL Gene at Home site.
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MPL Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for MPL

Summaries
for MPL

Genomic Location
for MPL

Proteins
for MPL

Protein Domains/
Families
for MPL

Gene Function
for MPL

Pathways & Interactions
for MPL

Drugs & Compounds
for MPL

Transcripts
for MPL

Expression
for MPL

Orthologs
for MPL

Paralogs
for MPL

SNPs/Variants
for MPL

Disorders & Mutations
for MPL

Medical News
for MPL

Publications
for MPL

Search for MPL

Genome Databases showing MPL

Other Databases showing MPL

Specialized Databases showing MPL

Licensable Technologies
for MPL

Services
for MPL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MPL Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor MPL

Summariesfor MPL

Genomic Locationfor MPL

Proteinsfor MPL

Protein Domains/Familiesfor MPL

Gene Functionfor MPL

Pathways & Interactionsfor MPL

Drugs & Compoundsfor MPL

Transcriptsfor MPL

Expression for MPL

Orthologsfor MPL

Paralogsfor MPL

SNPs/Variantsfor MPL

Disorders & Mutationsfor MPL

Medical Newsfor MPL

Publicationsfor MPL

Search for MPL

Genome Databases showing MPL

Other Databases showing MPL

Specialized Databases showing MPL

Licensable Technologiesfor MPL

Servicesfor MPL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MPL

Summaries
for MPL

Genomic Location
for MPL

Proteins
for MPL

Protein Domains/
Families
for MPL

Gene Function
for MPL

Pathways & Interactions
for MPL

Drugs & Compounds
for MPL

Transcripts
for MPL

Expression
for MPL

Orthologs
for MPL

Paralogs
for MPL

SNPs/Variants
for MPL

Disorders & Mutations
for MPL

Medical News
for MPL

Publications
for MPL

Licensable Technologies
for MPL

Services
for MPL