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Aliases for MPIG6B Gene

Aliases for MPIG6B Gene

  • Megakaryocyte And Platelet Inhibitory Receptor G6b 2 3 5
  • C6orf25 3 4
  • G6b 3 4
  • Chromosome 6 Open Reading Frame 25 2
  • Immunoglobulin Receptor 3
  • Protein G6b 3
  • G6b-B 3
  • THAMY 3
  • NG31 3

External Ids for MPIG6B Gene

Previous HGNC Symbols for MPIG6B Gene

  • C6orf25

Summaries for MPIG6B Gene

Entrez Gene Summary for MPIG6B Gene

  • This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MPIG6B Gene

MPIG6B (Megakaryocyte And Platelet Inhibitory Receptor G6b) is a Protein Coding gene. Diseases associated with MPIG6B include Gray Platelet Syndrome and Paraneoplastic Pemphigus. Among its related pathways are G beta-gamma signalling through PI3Kgamma and Response to elevated platelet cytosolic Ca2+.

UniProtKB/Swiss-Prot for MPIG6B Gene

  • Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. Appears to operate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be its activating counterpart.

Gene Wiki entry for MPIG6B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPIG6B Gene

Genomics for MPIG6B Gene

Regulatory Elements for MPIG6B Gene

Enhancers for MPIG6B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G031829 1.4 ENCODE dbSUPER 10.8 +115.6 115563 9.1 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D LSM2 LY6G5B ATF6B DDX39B SKIV2L VARS LY6G6C GTF2H4 CSNK2B BAG6
GH06G031733 1.9 FANTOM5 ENCODE dbSUPER 4.7 +18.9 18861 8.5 MLX CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP3 LY6G5C LSM2 LY6G5B VARS ABHD16A MICA EHMT2 PRRC2A C4A CLIC1
GH06G031717 1 ENCODE 0.7 -0.2 -156 2.0 HDGF PKNOX1 ATF1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF48 LY6G5C HLA-DRB1 CLIC1 MPIG6B LY6G6D
GH06G031720 0.6 ENCODE 0.7 +1.8 1805 0.2 CTBP1 POLR2A NR4A1 KLF4 ZNF600 SETDB1 RBFOX2 LY6G5C PSORS1C3 LY6G6C MPIG6B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MPIG6B on UCSC Golden Path with GeneCards custom track

Genomic Location for MPIG6B Gene

Chromosome:
6
Start:
31,718,594 bp from pter
End:
31,726,714 bp from pter
Size:
8,121 bases
Orientation:
Plus strand

Genomic View for MPIG6B Gene

Genes around MPIG6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPIG6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPIG6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MPIG6B Gene

  • Protein details for MPIG6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95866-G6B_HUMAN
    Recommended name:
    Protein G6b
    Protein Accession:
    O95866
    Secondary Accessions:
    • A2BEZ1
    • A2BEZ2
    • A2BEZ3
    • A2BEZ4
    • A2BEZ5
    • B0UXC4
    • B0UXC7
    • B0UXC8
    • B0V024
    • B0V026
    • Q14CK2
    • Q96A86
    • Q96A87
    • Q96A88
    • Q96A89
    • Q96A90
    • Q96A91

    Protein attributes for MPIG6B Gene

    Size:
    241 amino acids
    Molecular mass:
    26163 Da
    Quaternary structure:
    • Interacts with PTPN6 and PTPN11. Binds to heparin.

    Alternative splice isoforms for MPIG6B Gene

neXtProt entry for MPIG6B Gene

Post-translational modifications for MPIG6B Gene

No data available for DME Specific Peptides for MPIG6B Gene

Domains & Families for MPIG6B Gene

Protein Domains for MPIG6B Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MPIG6B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MPIG6B: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MPIG6B Gene

Function for MPIG6B Gene

Molecular function for MPIG6B Gene

UniProtKB/Swiss-Prot Function:
Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. Appears to operate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be its activating counterpart.

Gene Ontology (GO) - Molecular Function for MPIG6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23112346
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with MPIG6B: view
genes like me logo Genes that share phenotypes with MPIG6B: view

Animal Models for MPIG6B Gene

MGI Knock Outs for MPIG6B:
  • G6b tm1.1Arte

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MPIG6B Gene

Localization for MPIG6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPIG6B Gene

Isoform E: Endoplasmic reticulum. Golgi apparatus.
Isoform D: Endoplasmic reticulum. Golgi apparatus.
Isoform B: Cell membrane; Single-pass type I membrane protein.
Isoform A: Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPIG6B gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
extracellular 3
endoplasmic reticulum 3
lysosome 1

Gene Ontology (GO) - Cellular Components for MPIG6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MPIG6B: view

Pathways & Interactions for MPIG6B Gene

genes like me logo Genes that share pathways with MPIG6B: view

Pathways by source for MPIG6B Gene

Gene Ontology (GO) - Biological Process for MPIG6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007229 integrin-mediated signaling pathway IEA,ISS --
GO:0007596 blood coagulation ISS,IEA --
GO:0009968 negative regulation of signal transduction IDA 18955485
GO:0030168 platelet activation TAS --
GO:0030218 erythrocyte differentiation IMP 27743390
genes like me logo Genes that share ontologies with MPIG6B: view

No data available for SIGNOR curated interactions for MPIG6B Gene

Drugs & Compounds for MPIG6B Gene

(3) Drugs for MPIG6B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for MPIG6B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MPIG6B: view

Transcripts for MPIG6B Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPIG6B Gene

No ASD Table

Relevant External Links for MPIG6B Gene

GeneLoc Exon Structure for
MPIG6B
ECgene alternative splicing isoforms for
MPIG6B

Expression for MPIG6B Gene

NURSA nuclear receptor signaling pathways regulating expression of MPIG6B Gene:

MPIG6B

mRNA Expression by UniProt/SwissProt for MPIG6B Gene:

O95866-G6B_HUMAN
Tissue specificity: Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line U-937, the B-cell-like cell line Raji, the fibroblast cell lines TK and HeLa, or the natural killer cell lines NKL, NK 62 and YT. Expressed in platelets.

Evidence on tissue expression from TISSUES for MPIG6B Gene

  • Blood(4.4)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPIG6B Gene

Orthologs for MPIG6B Gene

This gene was present in the common ancestor of mammals.

Orthologs for MPIG6B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf25 34
  • 99.59 (n)
C6orf25 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C12H6orf25 34
  • 81.68 (n)
C6orf25 35
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia G6b 16 34
  • 77.92 (n)
AU023871 35
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia G6b 34
  • 77.87 (n)
cow
(Bos Taurus)
Mammalia C6ORF25 35
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C6orf25 35
  • 56 (a)
OneToOne
Species where no ortholog for MPIG6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MPIG6B Gene

ENSEMBL:
Gene Tree for MPIG6B (if available)
TreeFam:
Gene Tree for MPIG6B (if available)

Paralogs for MPIG6B Gene

No data available for Paralogs for MPIG6B Gene

Variants for MPIG6B Gene

Sequence variations from dbSNP and Humsavar for MPIG6B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000182864 -- 31,725,154(+) CTCAC(C/G)TGGAA downstream-variant-500B, utr-variant-3-prime
rs1001126146 -- 31,722,750(+) CTCAG(A/G)AGGCT intron-variant, upstream-variant-2KB
rs1001157311 -- 31,723,065(+) GCAAC(C/T)TCGAC intron-variant, upstream-variant-2KB
rs1001185679 -- 31,720,088(+) GGGAT(A/G)TTACC intron-variant, upstream-variant-2KB
rs1001215235 -- 31,719,657(+) TCAGC(C/T)TCCCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MPIG6B Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259

Variation tolerance for MPIG6B Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPIG6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MPIG6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPIG6B Gene

Disorders for MPIG6B Gene

MalaCards: The human disease database

(2) MalaCards diseases for MPIG6B Gene - From: GeneCards

Disorder Aliases PubMed IDs
gray platelet syndrome
  • bdplt4
paraneoplastic pemphigus
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MPIG6B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MPIG6B
genes like me logo Genes that share disorders with MPIG6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MPIG6B Gene

Publications for MPIG6B Gene

  1. G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2. (PMID: 11544253) de Vet E.C.M. … Campbell R.D. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro. (PMID: 17311996) Newland S.A. … Campbell D.R. (Blood 2007) 3 4 64
  3. The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin. (PMID: 15848171) de Vet E.C. … Campbell R.D. (FEBS Lett. 2005) 3 4 64
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for MPIG6B Gene

Sources for MPIG6B Gene

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