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Aliases for MPI Gene

Aliases for MPI Gene

  • Mannose Phosphate Isomerase 2 3 5
  • Phosphohexomutase 3 4
  • EC 4 63
  • PMI1 3 4
  • PMI 3 4
  • Mannose-6-Phosphate Isomerase 2
  • Phosphomannose Isomerase 1 3
  • Phosphomannose Isomerase 4
  • EC 5.3.1 63
  • CDG1B 3

External Ids for MPI Gene

Previous GeneCards Identifiers for MPI Gene

  • GC15U990034
  • GC15P068297
  • GC15P072758
  • GC15P072898
  • GC15P072969
  • GC15P075182
  • GC15P051979

Summaries for MPI Gene

Entrez Gene Summary for MPI Gene

  • Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for MPI Gene

MPI (Mannose Phosphate Isomerase) is a Protein Coding gene. Diseases associated with MPI include congenital disorder of glycosylation, type ib and protein-losing enteropathy. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include mannose-6-phosphate isomerase activity.

UniProtKB/Swiss-Prot for MPI Gene

  • Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPI Gene

Genomics for MPI Gene

Regulatory Elements for MPI Gene

Promoters for MPI Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MPI on UCSC Golden Path with GeneCards custom track

Genomic Location for MPI Gene

74,890,005 bp from pter
74,902,219 bp from pter
12,215 bases
Plus strand

Genomic View for MPI Gene

Genes around MPI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPI Gene

Proteins for MPI Gene

  • Protein details for MPI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mannose-6-phosphate isomerase
    Protein Accession:
    Secondary Accessions:
    • A8K8K9
    • Q96AB0

    Protein attributes for MPI Gene

    423 amino acids
    Molecular mass:
    46656 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MPI Gene


neXtProt entry for MPI Gene

Proteomics data for MPI Gene at MOPED

Post-translational modifications for MPI Gene

  • Ubiquitination at Lys 20, Lys 69, and Lys 87
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for MPI Gene

Suggested Antigen Peptide Sequences for MPI Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mannose-6-phosphate isomerase type 1 family.
  • Belongs to the mannose-6-phosphate isomerase type 1 family.
genes like me logo Genes that share domains with MPI: view

No data available for Gene Families for MPI Gene

Function for MPI Gene

Molecular function for MPI Gene

GENATLAS Biochemistry:
mannose phosphate isomerase
UniProtKB/Swiss-Prot CatalyticActivity:
D-mannose 6-phosphate = D-fructose 6-phosphate.
UniProtKB/Swiss-Prot Function:
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

Enzyme Numbers (IUBMB) for MPI Gene

Gene Ontology (GO) - Molecular Function for MPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MPI: view
genes like me logo Genes that share phenotypes with MPI: view

Human Phenotype Ontology for MPI Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MPI Gene

MGI Knock Outs for MPI:
  • Mpi tm1a(EUCOMM)Wtsi

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for MPI Gene

Localization for MPI Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPI Gene


Subcellular locations from

Jensen Localization Image for MPI Gene COMPARTMENTS Subcellular localization image for MPI gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 3
nucleus 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MPI Gene

Pathways & Interactions for MPI Gene

genes like me logo Genes that share pathways with MPI: view

UniProtKB/Swiss-Prot P34949-MPI_HUMAN

  • Pathway: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.

Interacting Proteins for MPI Gene

Gene Ontology (GO) - Biological Process for MPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0009298 GDP-mannose biosynthetic process IEA,TAS --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with MPI: view

No data available for SIGNOR curated interactions for MPI Gene

Drugs & Compounds for MPI Gene

(4) Drugs for MPI Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1477

(14) Additional Compounds for MPI Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Mannose 6-phosphate
  • alpha-D-Mannose-6-P
  • alpha-D-Mannose-6-phosphate
  • alpha-delta-Mannose-6-P
  • alpha-delta-Mannose-6-phosphate
  • D-Mannose 6-phosphate
Beta-D-Fructose 6-phosphate
  • beta-D-Fructose 6-phosphate
Fructose 6-phosphate
  • D-Fructose 6-phosphate
  • D-Fructose 6-phosphorate
  • D-Fructose 6-phosphoric acid
  • D-Fructose-6-P
  • D-Fructose-6-phosphate
genes like me logo Genes that share compounds with MPI: view

Transcripts for MPI Gene

Unigene Clusters for MPI Gene

Mannose phosphate isomerase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MPI Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7 ^ 8a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - - - - -
SP12: - - - - - - - - -
SP13: - - - - - - -
SP14: - - -
SP15: - -
SP16: -

ExUns: 8b

Relevant External Links for MPI Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPI Gene

mRNA expression in normal human tissues for MPI Gene

Protein differential expression in normal tissues from HIPED for MPI Gene

This gene is overexpressed in Salivary gland (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPI Gene

SOURCE GeneReport for Unigene cluster for MPI Gene Hs.75694

mRNA Expression by UniProt/SwissProt for MPI Gene

Tissue specificity: Expressed in all tissues, but more abundant in heart, brain and skeletal muscle.
genes like me logo Genes that share expression patterns with MPI: view

Protein tissue co-expression partners for MPI Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MPI Gene

Orthologs for MPI Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MPI Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MPI 36
  • 100 (a)
MPI 35
  • 99.68 (n)
  • 99.53 (a)
(Bos Taurus)
Mammalia MPI 35
  • 91.02 (n)
  • 91.25 (a)
MPI 36
  • 84 (a)
(Canis familiaris)
Mammalia MPI 36
  • 66 (a)
MPI 35
  • 87.97 (n)
  • 88.84 (a)
(Mus musculus)
Mammalia Mpi 36
  • 85 (a)
Mpi 35
  • 87 (n)
  • 84.63 (a)
Mpi 16
(Monodelphis domestica)
Mammalia MPI 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia MPI 36
  • 73 (a)
(Rattus norvegicus)
Mammalia Mpi 35
  • 86.52 (n)
  • 85.58 (a)
(Gallus gallus)
Aves MPI 35
  • 68.41 (n)
  • 63.1 (a)
MPI 36
  • 63 (a)
(Anolis carolinensis)
Reptilia MPI 36
  • 67 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4456 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mpi 35
  • 61.92 (n)
  • 63.18 (a)
Str.8465 35
(Danio rerio)
Actinopterygii mpi 36
  • 63 (a)
mpi 35
  • 65.72 (n)
  • 63.51 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000053 35
  • 51.38 (n)
  • 44.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8417 35
  • 51.25 (n)
  • 40.37 (a)
CG8417 37
  • 37 (a)
CG8417 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea C05C8.7 37
  • 36 (a)
ZK632.4 37
  • 40 (a)
ZK632.4 35
  • 49.74 (n)
  • 43.81 (a)
C05C8.7 36
  • 32 (a)
ZK632.4 36
  • 39 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR003C 35
  • 53.14 (n)
  • 44.01 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PMI40 35
  • 48.98 (n)
  • 41.77 (a)
PMI40 36
  • 39 (a)
PMI40 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13728g 35
  • 47.68 (n)
  • 42.79 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons DIN9 35
  • 49.49 (n)
  • 43.65 (a)
(Oryza sativa)
Liliopsida Os.34778 35
Os01g0127900 35
  • 51.09 (n)
  • 41.71 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07165 35
  • 50.9 (n)
  • 42.16 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC2G2.16 35
  • 47.76 (n)
  • 40.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
Species with no ortholog for MPI:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPI Gene

Gene Tree for MPI (if available)
Gene Tree for MPI (if available)

Paralogs for MPI Gene

No data available for Paralogs for MPI Gene

Variants for MPI Gene

Sequence variations from dbSNP and Humsavar for MPI Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1130741 -- 74,897,589(+) ACAGT(A/G)ATAGC reference, synonymous-codon, utr-variant-3-prime
rs2230479 -- 74,897,788(+) CCTCA(C/T)CTCCT utr-variant-3-prime
rs7497201 -- 74,898,349(+) GGGGG(A/G)GTGAG downstream-variant-500B, utr-variant-3-prime
rs8031937 -- 74,888,780(+) CACAT(A/G)TGGTA upstream-variant-2KB
rs11633472 -- 74,891,743(+) GGTAG(G/T)GACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPI Gene

Variant ID Type Subtype PubMed ID
nsv904381 CNV Loss 21882294
esv990390 CNV Deletion 20482838
esv1060905 CNV Insertion 17803354

Variation tolerance for MPI Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPI Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPI Gene

Disorders for MPI Gene

MalaCards: The human disease database

(12) MalaCards diseases for MPI Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
congenital disorder of glycosylation, type ib
  • congenital disorder of glycosylation 1b
protein-losing enteropathy
  • enteropathy, exudative
shaheen syndrome
  • shns
  • infection by onchocerca volvulus
cutaneous leishmaniasis
  • asian desert cutaneous leishmaniasis
- elite association - COSMIC cancer census association via MalaCards
Search MPI in MalaCards View complete list of genes associated with diseases


  • Congenital disorder of glycosylation 1B (CDG1B) [MIM:602579]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Congenital disorder of glycosylation type 1B is clinically characterized by protein-losing enteropathy. {ECO:0000269 PubMed:10980531, ECO:0000269 PubMed:11134235, ECO:0000269 PubMed:11350186, ECO:0000269 PubMed:12357336, ECO:0000269 PubMed:12414827, ECO:0000269 PubMed:9525984, ECO:0000269 PubMed:9585601}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MPI

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MPI: view

No data available for Genatlas for MPI Gene

Publications for MPI Gene

  1. Genomic organization of the human phosphomannose isomerase (MPI) gene and mutation analysis in patients with congenital disorders of glycosylation type Ib (CDG-Ib). (PMID: 10980531) Schollen E. … Matthijs G. (Hum. Mutat. 2000) 3 4 23 67
  2. Computational study of human phosphomannose isomerase: Insights from homology modeling and molecular dynamics simulation of enzyme bound substrate. (PMID: 16488169) Xiao J. … Sun P. (J. Mol. Graph. Model. 2006) 3 23
  3. DHPLC analysis as a platform for molecular diagnosis of congenital disorders of glycosylation (CDG). (PMID: 12357336) Schollen E. … Matthijs G. (Eur. J. Hum. Genet. 2002) 3 23
  4. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. (PMID: 11350186) Westphal V. … Freeze H.H. (Mol. Genet. Metab. 2001) 3 23
  5. Carbohydrate-deficient glycoprotein syndrome type Ib: phosphomannose isomerase deficiency and mannose therapy. (PMID: 9525984) Niehues R. … Marquardt T. (J. Clin. Invest. 1998) 3 23

Products for MPI Gene

Sources for MPI Gene

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