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Aliases for MPHOSPH9 Gene

Aliases for MPHOSPH9 Gene

  • M-Phase Phosphoprotein 9 2 3 5
  • MPP9 3 4
  • MPP-9 3

External Ids for MPHOSPH9 Gene

Previous GeneCards Identifiers for MPHOSPH9 Gene

  • GC12P122405
  • GC12M123338
  • GC12M123445
  • GC12M122074
  • GC12M122152
  • GC12M123637
  • GC12M120601

Summaries for MPHOSPH9 Gene

GeneCards Summary for MPHOSPH9 Gene

MPHOSPH9 (M-Phase Phosphoprotein 9) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPHOSPH9 Gene

Genomics for MPHOSPH9 Gene

Regulatory Elements for MPHOSPH9 Gene

Enhancers for MPHOSPH9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G123083 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21.4 +158.9 158928 3.9 ATF1 PKNOX1 CREB3L1 ARID4B ZNF143 FOS REST ZNF518A KAT8 SMARCA4 MPHOSPH9 PITPNM2 TCTN2 GTF2H3 C12orf65 ENSG00000256092 EIF2B1 PITPNM2-AS1 ENSG00000280381
GH12G123129 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.5 +110.9 110930 7.0 TBP ARID4B SIN3A RAD21 EGR1 FOS PAF1 ZNF680 ZNF654 GLIS1 CDK2AP1 MPHOSPH9 ENSG00000256092 VPS37B C12orf65 ABCB9 GC12P123128 PITPNM2
GH12G123119 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.4 +122.3 122324 4.3 PKNOX1 USF1 ZIC2 RFX5 SCRT2 ZNF143 CREM SRF MTA2 SMAD5 PITPNM2 MPHOSPH9 SNRNP35 C12orf65 HIP1R GC12P123128 ENSG00000280381
GH12G123040 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.6 +201.0 201001 4.1 HDAC1 FOXA2 ARID4B ZNF2 RAD21 RARA ZNF121 GLIS2 SCRT2 ZNF143 CDK2AP1 PITPNM2 MPHOSPH9 C12orf65 GC12P123016 PITPNM2-AS1
GH12G123147 1.4 ENCODE dbSUPER 21.6 +94.2 94216 5.0 CREB3L1 MLX AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZCCHC8 EIF2B1 CDK2AP1 KNTC1 LOC101927415 MPHOSPH9 ENSG00000256092 ATP6V0A2 ENSG00000206897 PITPNM2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MPHOSPH9 on UCSC Golden Path with GeneCards custom track

Genomic Location for MPHOSPH9 Gene

Chromosome:
12
Start:
123,152,320 bp from pter
End:
123,244,014 bp from pter
Size:
91,695 bases
Orientation:
Minus strand

Genomic View for MPHOSPH9 Gene

Genes around MPHOSPH9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPHOSPH9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPHOSPH9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPHOSPH9 Gene

Proteins for MPHOSPH9 Gene

  • Protein details for MPHOSPH9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99550-MPP9_HUMAN
    Recommended name:
    M-phase phosphoprotein 9
    Protein Accession:
    Q99550
    Secondary Accessions:
    • A1L486
    • A6NEE2
    • B3KR87
    • Q9H976
    • U3KQ28

    Protein attributes for MPHOSPH9 Gene

    Size:
    1183 amino acids
    Molecular mass:
    133024 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14359.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG52299.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW98394.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MPHOSPH9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPHOSPH9 Gene

Post-translational modifications for MPHOSPH9 Gene

No data available for DME Specific Peptides for MPHOSPH9 Gene

Domains & Families for MPHOSPH9 Gene

Protein Domains for MPHOSPH9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MPHOSPH9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MPHOSPH9: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MPHOSPH9 Gene

Function for MPHOSPH9 Gene

genes like me logo Genes that share phenotypes with MPHOSPH9: view

Animal Model Products

miRNA for MPHOSPH9 Gene

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPHOSPH9 Gene

Localization for MPHOSPH9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPHOSPH9 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus membrane; Peripheral membrane protein. Note=Localizes to the distal and proximal end of centriole pairs in duplicated centrosomes. In ciliated cells, localizes to the distal and proximal end of daughter centriole and proximal of the mother centriole but not in the distal end of the mother centriole.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPHOSPH9 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
nucleus 3
cytosol 3
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MPHOSPH9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA,IDA 8885239
GO:0005814 centriole IDA,IEA 23644468
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with MPHOSPH9: view

Pathways & Interactions for MPHOSPH9 Gene

SuperPathways for MPHOSPH9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MPHOSPH9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MPHOSPH9 Gene

Drugs & Compounds for MPHOSPH9 Gene

No Compound Related Data Available

Transcripts for MPHOSPH9 Gene

Unigene Clusters for MPHOSPH9 Gene

M-phase phosphoprotein 9:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPHOSPH9 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1: -
SP2: -
SP3: -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - - - -
SP8:
SP9: -
SP10: -
SP11: -
SP12: - - - -
SP13:
SP14:

ExUns: 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for MPHOSPH9 Gene

GeneLoc Exon Structure for
MPHOSPH9
ECgene alternative splicing isoforms for
MPHOSPH9

Expression for MPHOSPH9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MPHOSPH9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MPHOSPH9 Gene

This gene is overexpressed in Serum (48.3), Liver (10.0), and Pancreas (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MPHOSPH9 Gene



Protein tissue co-expression partners for MPHOSPH9 Gene

NURSA nuclear receptor signaling pathways regulating expression of MPHOSPH9 Gene:

MPHOSPH9

SOURCE GeneReport for Unigene cluster for MPHOSPH9 Gene:

Hs.577404

Evidence on tissue expression from TISSUES for MPHOSPH9 Gene

  • Blood(4.1)
genes like me logo Genes that share expression patterns with MPHOSPH9: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPHOSPH9 Gene

Orthologs for MPHOSPH9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MPHOSPH9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MPHOSPH9 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia MPHOSPH9 34 35
  • 88.5 (n)
cow
(Bos Taurus)
Mammalia MPHOSPH9 34 35
  • 87.5 (n)
rat
(Rattus norvegicus)
Mammalia Mphosph9 34
  • 79.76 (n)
mouse
(Mus musculus)
Mammalia Mphosph9 34 16 35
  • 79.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
OneToMany
-- 35
  • 44 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MPHOSPH9 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves MPHOSPH9 34 35
  • 68.57 (n)
lizard
(Anolis carolinensis)
Reptilia MPHOSPH9 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mphosph9 34
  • 55.65 (n)
zebrafish
(Danio rerio)
Actinopterygii MPHOSPH9 35
  • 38 (a)
OneToOne
Species where no ortholog for MPHOSPH9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPHOSPH9 Gene

ENSEMBL:
Gene Tree for MPHOSPH9 (if available)
TreeFam:
Gene Tree for MPHOSPH9 (if available)

Paralogs for MPHOSPH9 Gene

Pseudogenes.org Pseudogenes for MPHOSPH9 Gene

genes like me logo Genes that share paralogs with MPHOSPH9: view

No data available for Paralogs for MPHOSPH9 Gene

Variants for MPHOSPH9 Gene

Sequence variations from dbSNP and Humsavar for MPHOSPH9 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs886049038 Uncertain significance 123,233,354(+) CGAGG(G/T)AAAGA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs886049039 Uncertain significance 123,233,432(+) GAGTA(C/T)GGCGC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000109951 -- 123,159,158(+) GCAGG(G/T)ATTTT intron-variant
rs1000144839 -- 123,221,200(+) TACAG(A/T)TGGGA intron-variant
rs1000147791 -- 123,176,520(+) GCAAA(C/T)GCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPHOSPH9 Gene

Variant ID Type Subtype PubMed ID
esv2761773 CNV gain 21179565
esv3581949 CNV gain 25503493
nsv1113532 CNV deletion 24896259
nsv517200 CNV loss 19592680

Variation tolerance for MPHOSPH9 Gene

Residual Variation Intolerance Score: 31.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.40; 71.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPHOSPH9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MPHOSPH9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPHOSPH9 Gene

Disorders for MPHOSPH9 Gene

Relevant External Links for MPHOSPH9

Genetic Association Database (GAD)
MPHOSPH9
Human Genome Epidemiology (HuGE) Navigator
MPHOSPH9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MPHOSPH9

No disorders were found for MPHOSPH9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPHOSPH9 Gene

Publications for MPHOSPH9 Gene

  1. Identification of novel M phase phosphoproteins by expression cloning. (PMID: 8885239) Matsumoto-Taniura N. … Westendorf J.M. (Mol. Biol. Cell 1996) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. An application of Random Forests to a genome-wide association dataset: methodological considerations & new findings. (PMID: 20546594) Goldstein B.A. … Barcellos L.F. (BMC Genet. 2010) 3 46 64
  4. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. (PMID: 19525953) De Jager P.L. … Oksenberg J.R. (Nat. Genet. 2009) 3 46 64
  5. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. (PMID: 19879194) De Jager P.L. … Karlson E.W. (Lancet Neurol 2009) 3 46 64

Products for MPHOSPH9 Gene

Sources for MPHOSPH9 Gene

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