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MPHOSPH8 Gene

protein-coding GIFtS: 53
GCID: GC13P020208

M-Phase Phosphoprotein 8

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disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
M-Phase Phosphoprotein 8¹ ²		M-Phase Phosphoprotein, Mpp8²
Two Hybrid-Associated Protein 3 With RanBPM² ³		mpp8²
TWA3² ⁵		MPP8³
HSMPP8²		Twa3³
M-Phase Phosphoprotein, Mpp²

External Ids:	HGNC: 29810¹	Entrez Gene: 54737²	Ensembl: ENSG00000196199⁷	OMIM: 611626⁵	UniProtKB: Q99549³

Export aliases for MPHOSPH8 gene to outside databases

Previous GC identifers: GC13P019107 GC13P001012

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MPHOSPH8 Gene:

MPHOSPH8 (M-phase phosphoprotein 8) is a protein-coding gene. GO annotations related to this gene include methylated histone residue binding.

UniProtKB/Swiss-Prot: MPP8_HUMAN, Q99549

Function: Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone

H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within

the coding region of the gene. Mediates down-regulation of CDH1 expression

Gene Wiki entry for MPHOSPH8 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000013.10 NT_024524.15 NC_018924.2

Regulatory elements:

Regulatory transcription factor binding sites in the MPHOSPH8 gene promoter:
CREB POU2F1 POU2F1a deltaCREB MyoD AP-4 GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MPHOSPH8 promoter sequence

Search Chromatin IP Primers for MPHOSPH8

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MPHOSPH8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.11 Ensembl cytogenetic band: 13q12.11 HGNC cytogenetic band: 13q12.11

MPHOSPH8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPHOSPH8 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P020208: view genomic region (about GC identifiers)

Start:	20,207,788 bp from pter	End:	20,247,599 bp from pter
Size:	39,812 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MPP8_HUMAN, Q99549 (See protein sequence)

Recommended Name: M-phase phosphoprotein 8

Size: 860 amino acids; 97182 Da

Subunit: Homodimer. Interacts (via chromo domain) with histone H3K9me3. Has the highest affinity for H3K9me3, and

lesser affinity for H3K9me2 and H3K9me1. Interacts with DNMT3, EHMT1 and SETDB1

Sequence caution: Sequence=AAH46214.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAB71284.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI46172.1;

Type=Frameshift; Positions=248, 255, 731;

4 PDB 3D structures from and Proteopedia for MPHOSPH8:

3LWE (3D)

3QO2 (3D)

3R93 (3D)

3SVM (3D)

Secondary accessions: B7Z6F9 Q5JPE5 Q5JTQ0 Q86TK3 Q96MK4 Q9BTP1

Alternative splicing: 2 isoforms: Q99549-1 Q99549-2

Explore the universe of human proteins at neXtProt for MPHOSPH8: NX_Q99549

Explore proteomics data for MPHOSPH8 at MOPED

Post-translational modifications:

Phosphorylated in M (mitotic) phase¹

Ubiquitination² at Lys708

Modification sites at PhosphoSitePlus

See MPHOSPH8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_059990.2

ENSEMBL proteins:

ENSP00000355388 ENSP00000405941 ENSP00000414663

MPHOSPH8 Human Recombinant Protein Products:

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	Novus Biologicals MPHOSPH8 Proteins Novus Biologicals MPHOSPH8 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for MPHOSPH8
	Search eBioscience for Proteins for MPHOSPH8
	antibodies-online proteins for MPHOSPH8 (4 products)
	Search antibodies-online for peptides for MPHOSPH8

MPHOSPH8 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MPHOSPH8
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	antibodies-online antibodies for MPHOSPH8 (10 products)

MPHOSPH8 Assay Products:

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	Cloud-Clone Corp. ELISAs for MPHOSPH8 Cloud-Clone Corp. CLIAs for MPHOSPH8
	Search eBioscience for ELISAs for MPHOSPH8
	antibodies-online kits for MPHOSPH8 (2 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ANKRD: Ankyrin repeat domain containing

Selected InterPro protein domains (see all 6):

IPR000953 Chromo_domain/shadow

IPR023780 Chromo_domain

IPR016197 Chromodomain-like

IPR023779 Chromodomain_CS

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry Q99549

ProtoNet protein and cluster: Q99549

1 Blocks protein domain: IPB000953 Chromo domain

UniProtKB/Swiss-Prot: MPP8_HUMAN, Q99549

Domain: The chromo domain mediates interaction with methylated 'Lys-9' of histone H3 (H3K9me), with the highest

affinity for the trimethylated form (H3K9me3)

Similarity: Contains 4 ANK repeats

Similarity: Contains 1 chromo domain

Find genes that share domains with MPHOSPH8 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: MPP8_HUMAN, Q99549

Function: Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone

H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within

the coding region of the gene. Mediates down-regulation of CDH1 expression

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0035064	methylated histone residue binding	IDA	--

Find genes that share ontologies with MPHOSPH8 About GenesLikeMe

Phenotypes:
3 GenomeRNAi human phenotypes for MPHOSPH8:

Decreased Wnt reporter activit

Decreased nuclei size in G2M

Synthetic lethal with c-Myc af

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for MPHOSPH8

miRNA Products:		miRTarBase miRNAs that target MPHOSPH8: hsa-mir-26b-5p (MIRT030337), hsa-mir-20a-5p (MIRT050509)

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		Selected qRT-PCR Assays for microRNAs that regulate MPHOSPH8 (see all 19):
		hsa-miR-34b* hsa-miR-500a hsa-miR-3190 hsa-miR-378b hsa-miR-378 hsa-miR-325 hsa-miR-3148 hsa-miR-299-5p

		SwitchGear 3'UTR luciferase reporter plasmid: MPHOSPH8 3' UTR sequence

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Gene Editing
Products:

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Clone Products:		OriGene clones in human, mouse for MPHOSPH8 (see all 6) OriGene ORF clones in mouse, rat for MPHOSPH8 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MPHOSPH8 (NM_017520)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPHOSPH8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPHOSPH8
		Addgene plasmids for MPHOSPH8

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MPHOSPH8
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPHOSPH8

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

MPP8_HUMAN, Q99549: Nucleus. Note=Detected on heterochromatin. Detected on nucleosomes

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
plasma membrane	4
cytosol	2

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Gene Ontology (GO): Selected cellular component terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000788	nuclear nucleosome	IDA	--
GO:0005634	nucleus	IDA	--
GO:0005720	nuclear heterochromatin	IDA	--
GO:0005730	nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--

Find genes that share ontologies with MPHOSPH8 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for MPHOSPH8
Interactions:

Search GeneGlobe Interaction Network for MPHOSPH8

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MPHOSPH8 (Q99549^{1, 2, 3} ENSP00000355388⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 73)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H3A	P68431¹^,²	EBI-2653928,EBI-79722 MINT-8087223 MINT-8087250 MINT-8087372 MINT-8087395 MINT-8087409
HIST1H3B	P68431¹^,²	EBI-2653928,EBI-79722 MINT-8087223 MINT-8087250 MINT-8087372 MINT-8087395 MINT-8087409
HIST1H3C	P68431¹^,²	EBI-2653928,EBI-79722 MINT-8087223 MINT-8087250 MINT-8087372 MINT-8087395 MINT-8087409
HIST1H3D	P68431¹^,²	EBI-2653928,EBI-79722 MINT-8087223 MINT-8087250 MINT-8087372 MINT-8087395 MINT-8087409
HIST1H3E	P68431¹^,²	EBI-2653928,EBI-79722 MINT-8087223 MINT-8087250 MINT-8087372 MINT-8087395 MINT-8087409

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Gene Ontology (GO): 4 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-templated	IEA	--
GO:0007049	cell cycle	NAS	8885239
GO:0044030	regulation of DNA methylation	IMP	--
GO:0045892	negative regulation of transcription, DNA-templated	IMP	--

Find genes that share ontologies with MPHOSPH8 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for MPHOSPH8 (MPP8)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MPHOSPH8 gene:

NM_017520.3

Unigene Cluster for MPHOSPH8:

M-phase phosphoprotein 8

Hs.269654 [show with all ESTs]

Unigene Representative Sequence: NM_017520

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000361479(uc001umh.3) ENST00000467481 ENST00000449056 ENST00000496525

ENST00000414242(uc001umg.3 uc001umi.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat MPHOSPH8 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MPHOSPH8 (see all 19):
		hsa-miR-34b* hsa-miR-500a hsa-miR-3190 hsa-miR-378b hsa-miR-378 hsa-miR-325 hsa-miR-3148 hsa-miR-299-5p

		SwitchGear 3'UTR luciferase reporter plasmid: MPHOSPH8 3' UTR sequence

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		QuantiFast Probe-based Assays in human, mouse, rat MPHOSPH8

Additional mRNA sequence:

AJ293409.1 AK056785.1 AK092556.1 AK300258.1 AL832864.1 BC003542.1 BC017322.2 BC046214.1

X98259.1

Selected DOTS entries (see all 26):

DT.440607 DT.91837538 DT.95217970 DT.95283184 DT.454778 DT.100791650 DT.91721810 DT.120781551

DT.70102691 DT.86854823 DT.91721813 DT.95107792 DT.95369816 DT.120781431 DT.120781572 DT.120781538

DT.120781556 DT.40190319 DT.91759164 DT.97796598 DT.120781471 DT.120781525 DT.120781558 DT.91867504

Selected AceView cDNA sequences (see all 246):

X98259 AI927675 BF448730 AI271853 T34734 BQ945913 NM_017520 BQ071731

CB121595 C00915 BM716111 CF619015 BX105477 AI091066 CA771441 AW207221

AW969331 BE384922 BF591175 BM475270 BM692745 BG257698 BU164060 BQ706633

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for MPHOSPH8 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15a	·	15b
SP1:																															-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MPHOSPH8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MPHOSPH8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGGTGGAACA

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MPHOSPH8 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

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MPHOSPH8 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.269654

Custom PCR Arrays for MPHOSPH8

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPHOSPH8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MPHOSPH8 gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mphosph8^{1 , 5}	M-phase phosphoprotein 8^{1, 5}	80.55(n)¹ 78.82(a)¹		14 (28.37 cM)⁵ 75339¹ NM_023773.2¹ NP_076262.2¹ 56668248⁵
chicken (Gallus gallus)	Aves	MPHOSPH8¹	M-phase phosphoprotein 8	68.84(n) 65.8(a)		418957 NM_001171165.1 NP_001164636.1
lizard (Anolis carolinensis)	Reptilia	MPHOSPH8⁶	M-phase phosphoprotein 8	54(a)	1 ↔ 1	3(187005774-187029164)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.2500²	Transcribed sequence with weak similarity to protein more	78.33(n)		137693788
zebrafish (Danio rerio)	Actinopterygii	wufc38d04²	Transcribed sequence with weak similarity to protein more	79.1(n)		CK030356.1

ENSEMBL Gene Tree for MPHOSPH8 (if available)
TreeFam Gene Tree for MPHOSPH8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for MPHOSPH8 gene

3 SIMAP similar genes for MPHOSPH8 using alignment to 2 protein entries: MPP8_HUMAN (see all proteins):

PDXK CBX5 CBX1

Find genes that share paralogs with MPHOSPH8 About GenesLikeMe

1 Pseudogenes.org Pseudogene for MPHOSPH8
PGOHUM00000239306

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189531714^1,2	C	--	20205789(+)	`TGTGTG/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs181119196^1,2		--	20205795(+)	`TTTTTA/TGAGAC`	1	--	us2k¹		0	--	--	--	--
rs149647317^1,2		--	20205870(+)	`CCTCCC/TAGGCT`	1	--	us2k¹		0	--	--	--	--
rs186362789^1,2	C	--	20206048(+)	`TTCTGA/GGATTA`	1	--	us2k¹		0	--	--	--	--
rs115340048^1,2	F	--	20206189(+)	`AAATAT/CTTTAA`	1	--	us2k¹		1		WA	118
rs190388622^1,2		--	20206213(+)	`TTTCAC/TCTCAA`	1	--	us2k¹		0	--	--	--	--
rs148727923^1,2	C	--	20206270(+)	`ACTGGA/GAGAAA`	1	--	us2k¹		0	--	--	--	--
rs75090393^1,2	F	--	20206287(+)	`GTTGTC/TCAATA`	1	--	us2k¹		2		CSA WA	119
rs114456498^1,2	F	--	20206334(+)	`TTTTCC/TTCTTT`	1	--	us2k¹		1		WA	118
rs182943172^1,2		--	20206380(+)	`TAAAGA/GCCTGA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MPHOSPH8 (20207788 - 20247599 bp)

Structural Variations
Database of Genomic Variants (DGV) 6 variations for MPHOSPH8: About this table

Variant ID	Type	Subtype	PubMed ID
dgv334e199	CNV	Deletion	23128226
esv2747051	CNV	Deletion	23290073
nsv899856	CNV	Gain	21882294
nsv899857	CNV	Gain	21882294
nsv899855	CNV	Gain	21882294
nsv516945	CNV	Gain+Loss	19592680

Human Gene Mutation Database (HGMD): MPHOSPH8

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MPHOSPH8

DNA2.0 Custom Variant and Variant Library Synthesis for MPHOSPH8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611626 OMIM disorders: --

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Export disorders for MPHOSPH8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MPHOSPH8 gene, integrated from 10 sources (see all 27):
(articles sorted by number of sources associating them with MPHOSPH8)

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Identification of novel M phase phosphoproteins by expression cloning. (PubMed id 8885239)^{1, 2, 3} Matsumoto-Taniura N....Westendorf J.M. (Mol. Biol. Cell 1996)
Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9. (PubMed id 22022377)^{1, 2} Li J.... Zang J. (PLoS ONE 2011)
MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. (PubMed id 22086334)^{1, 2} Chang Y....Cheng X. (Nat. Commun. 2011)
Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding. (PubMed id 21419134)^{1, 2} Chang Y.... Cheng X. (J. Mol. Biol. 2011)
Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. (PubMed id 20871592)^{1, 2} Kokura K.... Fang J. (EMBO J. 2010)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (Nature 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Humanin binds MPP8: mapping interaction sites of the peptide and protein. (PubMed id 23532874)¹ Maximov V.V....Tarantul V.Z. (J. Pept. Sci. 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 54737	HGNC: 29810	AceView: HSMPP8	Ensembl:ENSG00000196199	euGenes: HUgn54737
ECgene: MPHOSPH8	H-InvDB: MPHOSPH8

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MPHOSPH8	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MPHOSPH8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MPHOSPH8 gene:
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MPHOSPH8 Gene

M-Phase Phosphoprotein 8

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