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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MPHOSPH8 Gene

protein-coding   GIFtS: 53
GCID: GC13P020208

M-Phase Phosphoprotein 8
  3 related diseases
at
MalaCards
 

Aliases
for MPHOSPH8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
M-Phase Phosphoprotein 81 2     M-Phase Phosphoprotein, Mpp82
Two Hybrid-Associated Protein 3 With RanBPM2 3     mpp82
TWA32 5     MPP83
HSMPP82     Twa33
M-Phase Phosphoprotein, Mpp2     

External Ids:    HGNC: 298101   Entrez Gene: 547372   Ensembl: ENSG000001961997   OMIM: 6116265   UniProtKB: Q995493   

Export aliases for MPHOSPH8 gene to outside databases

Previous GC identifers: GC13P019107 GC13P001012


Summaries
for MPHOSPH8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for MPHOSPH8 Gene: 
MPHOSPH8 (M-phase phosphoprotein 8) is a protein-coding gene. Diseases associated with MPHOSPH8 include pancreatic cancer, and pancreatitis. GO annotations related to this gene include methylated histone residue binding.

UniProtKB/Swiss-Prot: MPP8_HUMAN, Q99549
Function: Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone
H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within
the coding region of the gene. Mediates down-regulation of CDH1 expression

Gene Wiki entry for MPHOSPH8 Gene


Genomic Views
for MPHOSPH8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MPHOSPH8 gene promoter:
         CREB   POU2F1   POU2F1a   deltaCREB   MyoD   AP-4   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MPHOSPH8 promoter sequence
   Search SABiosciences Chromatin IP Primers for MPHOSPH8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPHOSPH8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.11   Ensembl cytogenetic band:  13q12.11   HGNC cytogenetic band: 13q12.11

MPHOSPH8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPHOSPH8 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P020208:  view genomic region     (about GC identifiers)

Start:
 20,207,788 bp from pter      End:
 20,247,599 bp from pter
Size:
 39,812 bases      Orientation:
 plus strand

Proteins
for MPHOSPH8 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: MPP8_HUMAN, Q99549 (See protein sequence)
Recommended Name: M-phase phosphoprotein 8  
Size: 860 amino acids; 97182 Da
Subunit: Homodimer. Interacts (via chromo domain) with histone H3K9me3. Has the highest affinity for H3K9me3, and
lesser affinity for H3K9me2 and H3K9me1. Interacts with DNMT3, EHMT1 and SETDB1
Subcellular location: Nucleus. Note=Detected on heterochromatin. Detected on nucleosomes
Sequence caution: Sequence=AAH46214.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB71284.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI46172.1;
Type=Frameshift; Positions=248, 255, 731;
4 PDB 3D structures from and Proteopedia for MPHOSPH8:
3LWE (3D)        3QO2 (3D)        3R93 (3D)        3SVM (3D)    
Secondary accessions: B7Z6F9 Q5JPE5 Q5JTQ0 Q86TK3 Q96MK4 Q9BTP1
Alternative splicing: 2 isoforms:  Q99549-1   Q99549-2   

Explore the universe of human proteins at neXtProt for MPHOSPH8: NX_Q99549

Explore proteomics data for MPHOSPH8 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated in M (mitotic) phase
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99549

    • MPHOSPH8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MPHOSPH8 Protein Expression
    REFSEQ proteins: NP_059990.2  
    ENSEMBL proteins: 
     ENSP00000355388   ENSP00000405941   ENSP00000414663  

    Human Recombinant Protein Products for MPHOSPH8: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MPHOSPH8
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MPHOSPH8
    GenScript Custom Purified and Recombinant Proteins Services for MPHOSPH8
    Novus Biologicals MPHOSPH8 Proteins
    Novus Biologicals MPHOSPH8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MPHOSPH8 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000788nuclear nucleosome IDA--
    GO:0005634nucleus IDA--
    GO:0005720nuclear heterochromatin IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    MPHOSPH8 for ontologies           About GeneDecksing



    MPHOSPH8 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MPHOSPH8
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    Novus Biologicals MPHOSPH8 Antibodies
    Abcam antibodies for MPHOSPH8
    Cloud-Clone Corp. Antibodies for MPHOSPH8 
    ThermoFisher Antibodies for MPHOSPH8
    LSBio Antibodies in human, mouse, rat for MPHOSPH8 

    Assay Products for MPHOSPH8: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MPHOSPH8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MPHOSPH8 
    Cloud-Clone Corp. CLIAs for MPHOSPH8

    Protein Domains /
    Families
    for MPHOSPH8 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    5/6 InterPro protein domains (see all 6):
     IPR000953 Chromo_domain/shadow
     IPR023780 Chromo_domain
     IPR016197 Chromodomain-like
     IPR023779 Chromodomain_CS
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q99549

    ProtoNet protein and cluster: Q99549

    1 Blocks protein domain: IPB000953 Chromo domain

    UniProtKB/Swiss-Prot: MPP8_HUMAN, Q99549
    Domain: The chromo domain mediates interaction with methylated 'Lys-9' of histone H3 (H3K9me), with the highest
    affinity for the trimethylated form (H3K9me3)
    Similarity: Contains 4 ANK repeats
    Similarity: Contains 1 chromo domain


    MPHOSPH8 for domains           About GeneDecksing


    Function
    for MPHOSPH8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPP8_HUMAN, Q99549
    Function: Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone
    H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within
    the coding region of the gene. Mediates down-regulation of CDH1 expression

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0035064methylated histone residue binding IDA--
         
    MPHOSPH8 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MPHOSPH8:
     Decreased Wnt reporter activit  Decreased nuclei size in G2M  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MPHOSPH8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MPHOSPH8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MPHOSPH8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MPHOSPH8 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPHOSPH8
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate MPHOSPH8 (see all 19):
    hsa-miR-34b* hsa-miR-500a hsa-miR-3190 hsa-miR-378b hsa-miR-378 hsa-miR-325 hsa-miR-3148 hsa-miR-299-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MPHOSPH8 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MPHOSPH8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPHOSPH8

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MPHOSPH8
    Sirion Biotech Customized adenovirus for overexpression of MPHOSPH8

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MPHOSPH8 (see all 7)
    OriGene ORF clones in mouse, rat for MPHOSPH8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MPHOSPH8 (NM_017520)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPHOSPH8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPHOSPH8
    Sirion Biotech Customized lentivirus for stable overexpression of MPHOSPH8 
                         Customized lentivirus expression plasmids for stable overexpression of MPHOSPH8 

    Cell Line
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    Search LifeMap BioReagents cell lines for MPHOSPH8
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPHOSPH8


    Pathways & Interactions
    for MPHOSPH8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MPHOSPH8

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/19 Interacting proteins for MPHOSPH8 (Q995492, 3 ENSP000003553884) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684312MINT-8087223 MINT-8087250 MINT-8087372 MINT-8087395 MINT-8087409
    HIST1H3BP684312MINT-8087223 MINT-8087250 MINT-8087372 MINT-8087395 MINT-8087409
    HIST1H3CP684312MINT-8087223 MINT-8087250 MINT-8087372 MINT-8087395 MINT-8087409
    HIST1H3DP684312MINT-8087223 MINT-8087250 MINT-8087372 MINT-8087395 MINT-8087409
    HIST1H3EP684312MINT-8087223 MINT-8087250 MINT-8087372 MINT-8087395 MINT-8087409
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007049cell cycle NAS8885239
    GO:0044030regulation of DNA methylation IMP--
    GO:0045892negative regulation of transcription, DNA-dependent IMP--

    MPHOSPH8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MPHOSPH8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MPHOSPH8 (MPP8)

    Search CenterWatch for drugs/clinical trials and news about MPHOSPH8 / MPP8

    Transcripts
    for MPHOSPH8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MPHOSPH8 gene: 
    NM_017520.3  

    Unigene Cluster for MPHOSPH8:

    M-phase phosphoprotein 8
    Hs.269654  [show with all ESTs]
    Unigene Representative Sequence: NM_017520
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361479(uc001umh.3) ENST00000467481 ENST00000449056 ENST00000496525
    ENST00000414242(uc001umg.3 uc001umi.3)
    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPHOSPH8
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate MPHOSPH8 (see all 19):
    hsa-miR-34b* hsa-miR-500a hsa-miR-3190 hsa-miR-378b hsa-miR-378 hsa-miR-325 hsa-miR-3148 hsa-miR-299-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MPHOSPH8 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MPHOSPH8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPHOSPH8
    Clone
    Products:             		 OriGene clones in human, mouse for MPHOSPH8 (see all 7)
    OriGene ORF clones in mouse, rat for MPHOSPH8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MPHOSPH8 (NM_017520)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPHOSPH8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPHOSPH8
    Sirion Biotech Customized lentivirus for stable overexpression of MPHOSPH8 
                         Customized lentivirus expression plasmids for stable overexpression of MPHOSPH8 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MPHOSPH8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPHOSPH8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPHOSPH8

    Additional mRNA sequence: 

    AJ293409.1 AK056785.1 AK092556.1 AK300258.1 AL832864.1 BC003542.1 BC017322.2 BC046214.1 
    X98259.1 

    24/26 DOTS entries (see all 26):

    DT.440607  DT.91837538  DT.95217970  DT.95283184  DT.454778  DT.100791650  DT.91721810  DT.120781551 
    DT.70102691  DT.86854823  DT.91721813  DT.95107792  DT.95369816  DT.120781431  DT.120781572  DT.120781538 
    DT.120781556  DT.40190319  DT.91759164  DT.97796598  DT.120781471  DT.120781525  DT.120781558  DT.91867504 

    24/246 AceView cDNA sequences (see all 246):

    AA054722 BG258142 AI927675 BQ706633 X98259 AI271853 CF619016 T16298 
    BQ636971 AI674362 CB121595 BI757931 BM692745 AI091066 BU178024 BM716111 
    AW207221 BQ071731 BM475270 BQ706428 Z45796 BG257698 BQ945913 T90105 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MPHOSPH8    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b
    SP1:                                                                                            -                     
    SP2:                                                                                                                  
    SP3:                                                                                                                  
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for MPHOSPH8

    Expression
    for MPHOSPH8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MPHOSPH8 expression in normal human tissues (normalized intensities)      MPHOSPH8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTGGAACA
    MPHOSPH8 Expression
    About this image


    MPHOSPH8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             prefrontal cortex   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See MPHOSPH8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MPHOSPH8

    SOURCE GeneReport for Unigene cluster: Hs.269654
        SABiosciences Custom PCR Arrays for MPHOSPH8
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPHOSPH8
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPHOSPH8

    Orthologs
    for MPHOSPH8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MPHOSPH8 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mphosph81 , 5 M-phase phosphoprotein 81, 5 81.02(n)1
    78.71(a)1    		   14 (28.37 cM)5
    753391  NM_023773.21  NP_076262.21 
     566682485 
    chicken
    (Gallus gallus)    		 Aves MPHOSPH81 M-phase phosphoprotein 8 68.88(n)
    65.56(a)    		   418957  NM_001171165.1  NP_001164636.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MPHOSPH86
    		 M-phase phosphoprotein 8
    		 52(a)
    		 1 ↔ 1
    		 3(187005774-187029164)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.25002 Transcribed sequence with weak similarity to protein more 78.33(n)    137693788 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc38d042 Transcribed sequence with weak similarity to protein more 79.1(n)    CK030356.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea cec-36
    		 Chromo domain-containing protein T09A5.8
    		 17(a)
    		 1 ↔ 1
    		 II(7855817-7857600)


    ENSEMBL Gene Tree for MPHOSPH8 (if available)
    TreeFam Gene Tree for MPHOSPH8 (if available)

    Paralogs
    for MPHOSPH8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MPHOSPH8 gene
    3 SIMAP similar genes for MPHOSPH8 using alignment to 2 protein entries:     MPP8_HUMAN (see all proteins):
    PDXK    CBX5    CBX1

    MPHOSPH8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MPHOSPH8
    PGOHUM00000239306


    Genomic Variants
    for MPHOSPH8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/963 SNPs in MPHOSPH8 are shown (see all 963)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1895317141,2
    		C--20205789(+) TGTGTG/TTTTTT 1 -- us2k10--------
    rs1811191961,2
    		--20205795(+) TTTTTA/TGAGAC 1 -- us2k10--------
    rs1496473171,2
    		--20205870(+) CCTCCC/TAGGCT 1 -- us2k10--------
    rs1863627891,2
    		C--20206048(+) TTCTGA/GGATTA 1 -- us2k10--------
    rs1153400481,2
    		F--20206189(+) AAATAT/CTTTAA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1903886221,2
    		--20206213(+) TTTCAC/TCTCAA 1 -- us2k10--------
    rs1487279231,2
    		C--20206270(+) ACTGGA/GAGAAA 1 -- us2k10--------
    rs750903931,2
    		F--20206287(+) GTTGTC/TCAATA 1 -- us2k12Minor allele frequency- T:0.04CSA WA 119
    rs1144564981,2
    		F--20206334(+) TTTTCC/TTCTTT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1829431721,2
    		--20206380(+) TAAAGA/GCCTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MPHOSPH8 (20207788 - 20247599 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MPHOSPH8:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv334e199CNV Deletion23128226
    esv2747051CNV Deletion23290073
    nsv899856CNV Gain21882294
    nsv899857CNV Gain21882294
    nsv899855CNV Gain21882294
    nsv516945CNV Gain+Loss19592680


    Human Gene Mutation Database (HGMD): MPHOSPH8
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPHOSPH8
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    Disorders / Diseases
    for MPHOSPH8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 611626    OMIM disorders: --

    3 diseases for MPHOSPH8:    About MalaCards
    pancreatic cancer    pancreatitis    retinitis


    MPHOSPH8 for disorders           About GeneDecksing


    Export disorders for MPHOSPH8 gene to outside databases

    Publications
    for MPHOSPH8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MPHOSPH8 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with MPHOSPH8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel M phase phosphoproteins by expression cloning. (PubMed id 8885239)1, 2, 3 Matsumoto-Taniura N....Westendorf J.M. (1996)
    2. Structural basis for specific binding of human MPP8 c hromodomain to histone H3 methylated at lysine 9. (PubMed id 22022377)1, 2 Li J....Zang J. (2011)
    3. MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. (PubMed id 22086334)1, 2 Chang Y....Cheng X. (2011)
    4. Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding. (PubMed id 21419134)1, 2 Chang Y....Cheng X. (2011)
    5. Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. (PubMed id 20871592)1, 2 Kokura K....Fang J. (2010)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. Mitotic phosphorylation of MPP8 by cyclin-dependent ki nases regulates chromatin dissociation. (PubMed id 23416073)1 Nishigaki M....Nakanishi M. (2013)

    External Searches for MPHOSPH8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing MPHOSPH8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54737 HGNC: 29810 AceView: HSMPP8 Ensembl:ENSG00000196199 euGenes: HUgn54737
    ECgene: MPHOSPH8 H-InvDB: MPHOSPH8

    Other Databases showing MPHOSPH8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MPHOSPH8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MPHOSPH8 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MPHOSPH8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MPHOSPH8 gene:
    Search GeneIP for patents involving MPHOSPH8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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