Aliases for MPHOSPH8 Gene
Aliases for MPHOSPH8 Gene
External Ids for MPHOSPH8 Gene
- HGNC: 29810
- Entrez Gene: 54737
- Ensembl: ENSG00000196199
- OMIM: 611626
- UniProtKB: Q99549
Previous GeneCards Identifiers for MPHOSPH8 Gene
- GC13P019107
- GC13P020208
- GC13P001012
Summaries for MPHOSPH8 Gene
GeneCards Summary for MPHOSPH8 Gene
MPHOSPH8 (M-Phase Phosphoprotein 8) is a Protein Coding gene. GO annotations related to this gene include methylated histone binding.
UniProtKB/Swiss-Prot for MPHOSPH8 Gene
-
Heterochromatin component that specifically recognizes and binds methylated Lys-9 of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPHOSPH8 Gene
Genomics for MPHOSPH8 Gene
Regulatory Elements for MPHOSPH8 Gene
Enhancers for MPHOSPH8 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MPHOSPH8 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MPHOSPH8 gene promoter:
Regulatory Element Products
Genomic Location for MPHOSPH8 Gene
- Chromosome:
- 13
- Start:
- 19,633,647 bp from pter
- End:
- 19,673,459 bp from pter
- Size:
- 39,813 bases
- Orientation:
- Plus strand
Genomic View for MPHOSPH8 Gene
Genes around MPHOSPH8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q12.11 by Ensembl
- 13q12.11 by Entrez Gene
- 13q12.11 by HGNC
MPHOSPH8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MPHOSPH8 Gene
Proteins for MPHOSPH8 Gene
-
Protein details for MPHOSPH8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99549-MPP8_HUMAN
- Recommended name:
- M-phase phosphoprotein 8
- Protein Accession:
- Q99549
- B7Z6F9
- Q5JPE5
- Q5JTQ0
- Q86TK3
- Q96MK4
- Q9BTP1
Protein attributes for MPHOSPH8 Gene
- Size:
- 860 amino acids
- Molecular mass:
- 97182 Da
- Quaternary structure:
-
- Homodimer (PubMed:21419134, PubMed:22022377, PubMed:22086334). Interacts (via chromo domain) with histone H3K9me3 (PubMed:20871592). Has the highest affinity for H3K9me3, and lesser affinity for H3K9me2 and H3K9me1 (PubMed:20871592). Component of the HUSH complex; at least composed of FAM208A/TASOR, PPHLN1 and MPHOSPH8 (PubMed:26022416). Interacts with DNMT3, EHMT1 and SETDB1 (PubMed:20871592, PubMed:22086334).
- SequenceCaution:
-
- Sequence=AAH46214.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB71284.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI46172.1; Type=Frameshift; Positions=248, 255, 731; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for MPHOSPH8 Gene
Protein Expression for MPHOSPH8 Gene
Post-translational modifications for MPHOSPH8 Gene
- Phosphorylated in M (mitotic) phase. Phosphorylation by CDK1 promotes dissociation from chromatin.
- Ubiquitination at posLast=708708
- Modification sites at PhosphoSitePlus
Other Protein References for MPHOSPH8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for MPHOSPH8
- Novus Biologicals Antibodies for MPHOSPH8
- Invitrogen Antibodies for MPHOSPH8
- antibodies-online Antibodies for MPHOSPH8: See all 15
- Search GeneTex for Antibodies for MPHOSPH8
-
Santa Cruz Biotechnology (SCBT) Antibodies for MPHOSPH8
Protein Products
-
OriGene Purified Proteins for MPHOSPH8
- Search Origene for MassSpec and Protein Over-expression Lysates for MPHOSPH8
- Origene Custom Protein Services for MPHOSPH8
- antibodies-online Proteins for MPHOSPH8: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for MPHOSPH8
Assay Products
No data available for DME Specific Peptides for MPHOSPH8 Gene
Domains & Families for MPHOSPH8 Gene
Gene Families for MPHOSPH8 Gene
Protein Domains for MPHOSPH8 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MPHOSPH8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99549UniProtKB/Swiss-Prot:
MPP8_HUMAN :- The chromo domain mediates interaction with methylated Lys-9 of histone H3 (H3K9me), with the highest affinity for the trimethylated form (H3K9me3).
- Domain:
-
- The chromo domain mediates interaction with methylated Lys-9 of histone H3 (H3K9me), with the highest affinity for the trimethylated form (H3K9me3).
Function for MPHOSPH8 Gene
Molecular function for MPHOSPH8 Gene
- UniProtKB/Swiss-Prot Function:
- Heterochromatin component that specifically recognizes and binds methylated Lys-9 of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 20871592 |
| GO:0031625 | ubiquitin protein ligase binding | IBA | -- |
| GO:0035064 | methylated histone binding | IDA | 20871592 |
Phenotypes for MPHOSPH8 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MPHOSPH8
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MPHOSPH8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MPHOSPH8 gene
- Search ViGene Biosciences for MPHOSPH8
CRISPR Products
-
OriGene CRISPR knockouts for MPHOSPH8
-
Santa Cruz Biotechnology (SCBT) CRISPR for MPHOSPH8
- GenScript: Design CRISPR guide RNA sequences for MPHOSPH8
miRNA for MPHOSPH8 Gene
- miRTarBase miRNAs that target MPHOSPH8
-
- hsa-mir-26b-5p (MIRT030337)
- hsa-mir-20a-5p (MIRT050509)
- hsa-mir-545-3p (MIRT646309)
- hsa-mir-216b-3p (MIRT646310)
- hsa-mir-7843-5p (MIRT646311)
- hsa-mir-6879-5p (MIRT646312)
- hsa-mir-6735-5p (MIRT646313)
- hsa-mir-4632-5p (MIRT646314)
- hsa-mir-4436b-3p (MIRT646315)
- hsa-mir-1273e (MIRT663229)
- hsa-mir-6516-5p (MIRT663230)
- hsa-mir-455-3p (MIRT663231)
- hsa-mir-650 (MIRT663232)
- hsa-mir-3612 (MIRT663233)
- hsa-mir-4327 (MIRT663234)
- hsa-mir-6499-3p (MIRT663235)
- hsa-mir-4722-5p (MIRT663236)
- hsa-mir-1827 (MIRT663237)
- hsa-mir-4649-3p (MIRT663238)
- hsa-mir-6840-3p (MIRT663239)
- hsa-mir-665 (MIRT663240)
- hsa-mir-4459 (MIRT663241)
- hsa-mir-4768-3p (MIRT663242)
- hsa-mir-6500-3p (MIRT663243)
- hsa-mir-3614-5p (MIRT663244)
- hsa-mir-940 (MIRT663245)
- hsa-mir-6893-5p (MIRT663246)
- hsa-mir-6808-5p (MIRT663247)
- hsa-mir-6511a-5p (MIRT663248)
- hsa-mir-4695-5p (MIRT663249)
- hsa-mir-34b-3p (MIRT663250)
miRNA Products
- Search ViGene Biosciences for MPHOSPH8
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for MPHOSPH8
- Browse OriGene Inhibitory RNA Products For MPHOSPH8
-
ViGene Biosciences ready-to-package AAV shRNAs for MPHOSPH8 gene
Clone Products
-
OriGene ORF clones in human for MPHOSPH8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Addgene plasmids for MPHOSPH8
- VectorBuilder custom plasmid, inducible vectors for MPHOSPH8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MPHOSPH8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for MPHOSPH8
-
ViGene Biosciences adenoviral particle packaged cDNA for MPHOSPH8 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MPHOSPH8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MPHOSPH8 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPHOSPH8 Gene
Localization for MPHOSPH8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MPHOSPH8 Gene
- Nucleus. Chromosome. Note=Detected on heterochromatin (PubMed:20871592, PubMed:26022416). Dissociates from chromatin during interphase and early mitosis (PubMed:23416073). Detected on nucleosomes (PubMed:20871592). {ECO:0000269 PubMed:20871592, ECO:0000269 PubMed:23416073, ECO:0000269 PubMed:26022416}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IBA | -- |
| GO:0000788 | nuclear nucleosome | IDA | 20871592 |
| GO:0005634 | nucleus | IDA | 8885239 |
| GO:0005694 | chromosome | IEA | -- |
| GO:0005720 | nuclear heterochromatin | IDA | 20871592 |
Pathways & Interactions for MPHOSPH8 Gene
No Data Available
Interacting Proteins for MPHOSPH8 Gene
Selected Interacting proteins:
ENSP00000355388
Q99549-MPP8_HUMAN
for MPHOSPH8 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0044030 | regulation of DNA methylation | IMP | 20871592 |
| GO:0045892 | negative regulation of transcription, DNA-templated | IMP | 20871592 |
No data available for Pathways by source and SIGNOR curated interactions for MPHOSPH8 Gene
Transcripts for MPHOSPH8 Gene
mRNA/cDNA for MPHOSPH8 Gene
- (246) Selected AceView cDNA sequences:
- (9) Additional mRNA sequences :
- (2) REFSEQ mRNAs :
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MPHOSPH8 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MPHOSPH8
-
Santa Cruz Biotechnology (SCBT) CRISPR for MPHOSPH8
- GenScript: Design CRISPR guide RNA sequences for MPHOSPH8
miRNA Products
- Search ViGene Biosciences for MPHOSPH8
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for MPHOSPH8
- Browse OriGene Inhibitory RNA Products For MPHOSPH8
-
ViGene Biosciences ready-to-package AAV shRNAs for MPHOSPH8 gene
Clone Products
-
OriGene ORF clones in human for MPHOSPH8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MPHOSPH8
- VectorBuilder custom plasmid, inducible vectors for MPHOSPH8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MPHOSPH8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||
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| SP5: |
Expression for MPHOSPH8 Gene
This gene is overexpressed in Testis (14.0), Peripheral blood mononuclear cells (12.1), Heart (7.9), and Pancreas (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MPHOSPH8 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MPHOSPH8 Gene:
MPHOSPH8SOURCE GeneReport for Unigene cluster for MPHOSPH8 Gene:
Hs.269654Evidence on tissue expression from TISSUES for MPHOSPH8 Gene
- Nervous system(4.6)
- Liver(4.3)
- Lymph node(4.3)
- Pancreas(4.3)
- Blood(4.2)
- Intestine(3.6)
- Spleen(2.1)
Primer Products
-
OriGene qPCR primer pairs for MPHOSPH8
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPHOSPH8 Gene
Orthologs for MPHOSPH8 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MPHOSPH8 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | MPHOSPH8 34 |
|
||
| cow (Bos Taurus) |
Mammalia | MPHOSPH8 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mphosph8 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Mphosph8 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MPHOSPH8 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MPHOSPH8 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MPHOSPH8 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MPHOSPH8 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mphosph8 34 |
|
||
| Str.2500 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | mphosph8 35 |
|
OneToOne | |
| wufc38d04 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4384 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany |
- Species where no ortholog for MPHOSPH8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MPHOSPH8 Gene
(3) SIMAP similar genes for MPHOSPH8 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for MPHOSPH8 Gene
No data available for Paralogs for MPHOSPH8 Gene
Variants for MPHOSPH8 Gene
| SNP ID | Clin | Chr 13 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000077422 | -- | 19,672,533(+) | AGCTC(C/T)AAAAC | nc-transcript-variant, utr-variant-3-prime | |
| rs1000197650 | -- | 19,646,752(+) | AAGAA(C/T)TAAAG | nc-transcript-variant, reference, synonymous-codon | |
| rs1000457086 | -- | 19,649,917(+) | CTTGT(C/T)GCTTT | intron-variant | |
| rs1000509589 | -- | 19,656,373(+) | TAGCA(A/C)GGTGA | intron-variant | |
| rs1000580413 | -- | 19,655,045(+) | GTTTT(A/T)AAAAA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1607n100 | CNV | gain | 25217958 |
| dgv1608n100 | CNV | gain | 25217958 |
| dgv334e199 | CNV | deletion | 23128226 |
| esv2747051 | CNV | deletion | 23290073 |
| esv2761244 | CNV | gain | 21179565 |
| esv3582126 | CNV | gain | 25503493 |
| esv3582138 | CNV | gain | 25503493 |
| esv3631393 | CNV | gain | 21293372 |
| esv3631396 | CNV | gain | 21293372 |
| esv3631398 | CNV | gain | 21293372 |
| esv3892298 | CNV | gain | 25118596 |
| esv3892299 | CNV | gain | 25118596 |
| nsv1041042 | CNV | gain | 25217958 |
| nsv1047555 | CNV | loss | 25217958 |
| nsv1051666 | CNV | gain | 25217958 |
| nsv1054226 | CNV | gain | 25217958 |
| nsv1078303 | OTHER | inversion | 25765185 |
| nsv1115628 | CNV | deletion | 24896259 |
| nsv1140246 | OTHER | inversion | 24896259 |
| nsv1148310 | CNV | deletion | 26484159 |
| nsv1151909 | OTHER | inversion | 26484159 |
| nsv516945 | CNV | gain+loss | 19592680 |
| nsv977201 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.69;
57.28% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MPHOSPH8 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPHOSPH8 Gene
Disorders for MPHOSPH8 Gene
Relevant External Links for MPHOSPH8
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- MPHOSPH8
No disorders were found for MPHOSPH8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPHOSPH8 Gene
Publications for MPHOSPH8 Gene
- Identification of novel M phase phosphoproteins by expression cloning. (PMID: 8885239) Matsumoto-Taniura N. … Westendorf J.M. (Mol. Biol. Cell 1996) 2 3 4 64
- Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells. (PMID: 26022416) Tchasovnikarova I.A. … Lehner P.J. (Science 2015) 3 4 64
- Mitotic phosphorylation of MPP8 by cyclin-dependent kinases regulates chromatin dissociation. (PMID: 23416073) Nishigaki M. … Nakanishi M. (Biochem. Biophys. Res. Commun. 2013) 3 4 64
- Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding. (PMID: 21419134) Chang Y. … Cheng X. (J. Mol. Biol. 2011) 3 4 64
- Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9. (PMID: 22022377) Li J. … Zang J. (PLoS ONE 2011) 3 4 64
Products for MPHOSPH8 Gene
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- Novus Biologicals Antibodies for MPHOSPH8
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- Novus Biologicals
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- Addgene plasmids for MPHOSPH8
- antibodies-online Antibodies for MPHOSPH8: See all 15
- Search antibodies-online for kits
- antibodies-online Proteins for MPHOSPH8: See all 4
- Search antibodies-online for peptides
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- ViGene Biosciences adenoviral particle packaged cDNA for MPHOSPH8 gene
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- Search ViGene Biosciences for MPHOSPH8
- Santa Cruz Biotechnology (SCBT) Antibodies for MPHOSPH8
- Search Santa Cruz Biotechnology (SCBT) for MPHOSPH8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MPHOSPH8
- Horizon Cell Lines for MPHOSPH8
- Cyagen custom Knockout/knockin (KOKI) mouse models for MPHOSPH8
- VectorBuilder custom plasmid, inducible vectors for MPHOSPH8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MPHOSPH8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MPHOSPH8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer