MPHOSPH8 Gene

Aliases
for MPHOSPH8 gene

Previous GC identifers: GC13P019107 GC13P001012

Summaries
for MPHOSPH8 gene

Genomic Views
for MPHOSPH8 gene

RefSeq DNA sequence:

NC_000013.10  NC_018924.1  NT_024524.14  

SwitchGear Promoter luciferase reporter plasmids (see all 2): MPHOSPH8 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPHOSPH8

MPHOSPH8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P020208:  view genomic region     (about GC identifiers)

Proteins
for MPHOSPH8 gene

4 PDB 3D structures from and Proteopedia for MPHOSPH8:

3LWE (3D)        3QO2 (3D)        3R93 (3D)        3SVM (3D)    

Explore the universe of human proteins at neXtProt for MPHOSPH8: NX_Q99549

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: MPHOSPH8 OriGene Custom Protein Services for MPHOSPH8
	GenScript Custom Purified and Recombinant Proteins Services for MPHOSPH8
	Novus Biologicals MPHOSPH8 Proteins Novus Biologicals MPHOSPH8 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MPHOSPH8

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MPHOSPH8
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for MPHOSPH8
	GenScript Custom Superior Antibodies Services for MPHOSPH8
	Novus Biologicals MPHOSPH8 Antibodies
	Search for Antibodies for MPHOSPH8 at Abcam
	Uscn Antibodies for MPHOSPH8
	ThermoFisher Antibodies for MPHOSPH8

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MPHOSPH8
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MPHOSPH8

Protein Domains /
Families
for MPHOSPH8 gene

ProtoNet protein and cluster: Q99549

Function
for MPHOSPH8 gene

miRNA Products:		OriGene 3'-UTR Clone: MPHOSPH8 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPHOSPH8
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate MPHOSPH8 (see all 19):
		hsa-miR-34b* hsa-miR-500a hsa-miR-3190 hsa-miR-378b hsa-miR-378 hsa-miR-325 hsa-miR-3148 hsa-miR-299-5p
		SwitchGear 3'UTR luciferase reporter plasmid: MPHOSPH8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPHOSPH8 (see all 7) OriGene shRNA RFP: MPHOSPH8 OriGene siRNA: MPHOSPH8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPHOSPH8

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for MPHOSPH8

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPHOSPH8 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPHOSPH8 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MPHOSPH8 (NM_017520)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPHOSPH8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPHOSPH8

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MPHOSPH8
		Search LifeMap BioReagents cell lines for MPHOSPH8

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPHOSPH8

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

Pathways & Interactions
for MPHOSPH8 gene

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for MPHOSPH8 gene

Transcripts
for MPHOSPH8 gene

Expression
for MPHOSPH8 gene

MPHOSPH8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGTGGAACA

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	HeartLeft Ventricle			Heart
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPHOSPH8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MPHOSPH8
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPHOSPH8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPHOSPH8

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPHOSPH8

Orthologs
for MPHOSPH8 gene

Paralogs
for MPHOSPH8 gene

Paralogs for MPHOSPH8 gene

CBX1²  CBX3²  CBX5²  

3 SIMAP similar genes for MPHOSPH8 using alignment to 2 protein entries:     MPP8_HUMAN (see all proteins):

PDXK    CBX5    CBX1

MPHOSPH8 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for MPHOSPH8
PGOHUM00000239306

Genomic Variants
for MPHOSPH8 gene

10/789 NCBI SNPs in MPHOSPH8 are shown (see all 789)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1895317141,2		--	20205789(+)	TGTGTG/TTTTTT	1	--	us2k1		0	--	--	--	--
rs1811191961,2		--	20205795(+)	TTTTTA/TGAGAC	1	--	us2k1		0	--	--	--	--
rs1496473171,2		--	20205870(+)	CCTCCC/TAGGCT	1	--	us2k1		0	--	--	--	--
rs1863627891,2		--	20206048(+)	TTCTGA/GGATTA	1	--	us2k1		0	--	--	--	--
rs1153400481,2	F,	--	20206189(+)	AAATAT/CTTTAA	1	--	us2k1		1		WA	118
rs1903886221,2		--	20206213(+)	TTTCAC/TCTCAA	1	--	us2k1		0	--	--	--	--
rs1487279231,2		--	20206270(+)	ACTGGA/GAGAAA	1	--	us2k1		0	--	--	--	--
rs750903931,2		--	20206287(+)	GTTGTC/TCAATA	1	--	us2k1		2		CSA WA	119
rs1144564981,2	F,	--	20206334(+)	TTTTCC/TTCTTT	1	--	us2k1		1		WA	118
rs1829431721,2		--	20206380(+)	TAAAGA/GCCTGA	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for MPHOSPH8 (20207788 - 20247599 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MPHOSPH8
     1 CNV: 49182
Human Gene Mutation Database (HGMD): MPHOSPH8

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPHOSPH8

DNA2.0 Custom Variant and Variant Library Synthesis for MPHOSPH8

Disorders / Diseases
for MPHOSPH8 gene

Publications
for MPHOSPH8 gene

PubMed articles for MPHOSPH8 gene, integrated from 9 sources (see all 23): (articles sorted by number of sources associating them with MPHOSPH8)

Utopia: connect your pdf to the dynamic world of online information

1. Identification of novel M phase phosphoproteins by expression cloning. (PubMed id 8885239)^{1, 2, 3} Matsumoto-Taniura N....Westendorf J.M. (1996)
2. Structural basis for specific binding of human MPP8 c hromodomain to histone H3 methylated at lysine 9. (PubMed id 22022377)^{1, 2} Li J....Zang J. (2011)
3. MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. (PubMed id 22086334)^{1, 2} Chang Y....Cheng X. (2011)
4. Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding. (PubMed id 21419134)^{1, 2} Chang Y....Cheng X. (2011)
5. Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. (PubMed id 20871592)^{1, 2} Kokura K....Fang J. (2010)
6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
7. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (2004)
8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)

External Searches for MPHOSPH8 gene

Genome Databases showing MPHOSPH8 gene

Other Databases showing MPHOSPH8 gene

Specialized Databases showing MPHOSPH8 gene

Products
for MPHOSPH8 gene