MPHOSPH8 Gene

Aliases
for MPHOSPH8 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC13P019107 GC13P001012

Summaries
for MPHOSPH8 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for MPHOSPH8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000013.10  NT_024524.15  NC_018924.2  

SwitchGear Promoter luciferase reporter plasmids (see all 2): MPHOSPH8 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MPHOSPH8

MPHOSPH8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P020208:  view genomic region     (about GC identifiers)

Proteins
for MPHOSPH8 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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4 PDB 3D structures from and Proteopedia for MPHOSPH8:

3LWE (3D)        3QO2 (3D)        3R93 (3D)        3SVM (3D)    

Explore the universe of human proteins at neXtProt for MPHOSPH8: NX_Q99549

Explore proteomics data for MPHOSPH8 at MOPED

Post-translational modifications: 

MPHOSPH8 Human Recombinant Protein Products:

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	antibodies-online proteins for MPHOSPH8 (4 products)
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MPHOSPH8 Antibody Products:

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	antibodies-online antibodies for MPHOSPH8 (10 products)

MPHOSPH8 Assay Products:

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	antibodies-online kits for MPHOSPH8 (2 products)

Domains /
Families
for MPHOSPH8 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q99549

Find genes that share domains with MPHOSPH8           About GenesLikeMe

Function
for MPHOSPH8 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for MPHOSPH8

miRNA Products:		miRTarBase miRNAs that target MPHOSPH8: hsa-mir-26b-5p (MIRT030337), hsa-mir-20a-5p (MIRT050509)
		Block miRNA regulation of human, mouse, rat MPHOSPH8 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MPHOSPH8 (see all 19):
		hsa-miR-34b* hsa-miR-500a hsa-miR-3190 hsa-miR-378b hsa-miR-378 hsa-miR-325 hsa-miR-3148 hsa-miR-299-5p
		SwitchGear 3'UTR luciferase reporter plasmid: MPHOSPH8 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MPHOSPH8
		Predesigned siRNA for gene silencing in human, mouse, rat MPHOSPH8

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for MPHOSPH8

Clone Products:		OriGene clones in human, mouse for MPHOSPH8 (see all 6) OriGene ORF clones in mouse, rat for MPHOSPH8 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPHOSPH8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPHOSPH8
		Addgene plasmids for MPHOSPH8

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MPHOSPH8
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPHOSPH8

Localization
for MPHOSPH8 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5
plasma membrane	4
cytosol	2

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Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

Pathways & Interactions
for MPHOSPH8 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 4 biological process terms:    About this table

Drugs & Compounds
for MPHOSPH8 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for MPHOSPH8 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for MPHOSPH8 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MPHOSPH8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGGTGGAACA

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for MPHOSPH8
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MPHOSPH8
		QuantiTect SYBR Green Assays in human, mouse, rat MPHOSPH8
		QuantiFast Probe-based Assays in human, mouse, rat MPHOSPH8

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPHOSPH8

Orthologs
for MPHOSPH8 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for MPHOSPH8 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for MPHOSPH8 gene

3 SIMAP similar genes for MPHOSPH8 using alignment to 2 protein entries:     MPP8_HUMAN (see all proteins):

PDXK    CBX5    CBX1

Find genes that share paralogs with MPHOSPH8           About GenesLikeMe


1 Pseudogenes.org Pseudogene for MPHOSPH8
PGOHUM00000239306

Genomic Variants
for MPHOSPH8 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MPHOSPH8 (see all 963)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1895317141,2	C	--	20205789(+)	TGTGTG/TTTTTT	1	--	us2k1		0	--	--	--	--
rs1811191961,2		--	20205795(+)	TTTTTA/TGAGAC	1	--	us2k1		0	--	--	--	--
rs1496473171,2		--	20205870(+)	CCTCCC/TAGGCT	1	--	us2k1		0	--	--	--	--
rs1863627891,2	C	--	20206048(+)	TTCTGA/GGATTA	1	--	us2k1		0	--	--	--	--
rs1153400481,2	F	--	20206189(+)	AAATAT/CTTTAA	1	--	us2k1		1		WA	118
rs1903886221,2		--	20206213(+)	TTTCAC/TCTCAA	1	--	us2k1		0	--	--	--	--
rs1487279231,2	C	--	20206270(+)	ACTGGA/GAGAAA	1	--	us2k1		0	--	--	--	--
rs750903931,2	F	--	20206287(+)	GTTGTC/TCAATA	1	--	us2k1		2		CSA WA	119
rs1144564981,2	F	--	20206334(+)	TTTTCC/TTCTTT	1	--	us2k1		1		WA	118
rs1829431721,2		--	20206380(+)	TAAAGA/GCCTGA	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for MPHOSPH8 (20207788 - 20247599 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for MPHOSPH8:    About this table    

Variant ID	Type	Subtype	PubMed ID
dgv334e199	CNV	Deletion	23128226
esv2747051	CNV	Deletion	23290073
nsv899856	CNV	Gain	21882294
nsv899857	CNV	Gain	21882294
nsv899855	CNV	Gain	21882294
nsv516945	CNV	Gain+Loss	19592680

Human Gene Mutation Database (HGMD): MPHOSPH8

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MPHOSPH8

DNA2.0 Custom Variant and Variant Library Synthesis for MPHOSPH8

Disorders / Diseases
for MPHOSPH8 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for MPHOSPH8 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Identification of novel M phase phosphoproteins by expression cloning. (PubMed id 8885239)^{1, 2, 3} Matsumoto-Taniura N....Westendorf J.M. (Mol. Biol. Cell 1996)
2. Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9. (PubMed id 22022377)^{1, 2} Li J.... Zang J. (PLoS ONE 2011)
3. MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. (PubMed id 22086334)^{1, 2} Chang Y....Cheng X. (Nat. Commun. 2011)
4. Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding. (PubMed id 21419134)^{1, 2} Chang Y.... Cheng X. (J. Mol. Biol. 2011)
5. Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. (PubMed id 20871592)^{1, 2} Kokura K.... Fang J. (EMBO J. 2010)
6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
7. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (Nature 2004)
8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
10. Humanin binds MPP8: mapping interaction sites of the peptide and protein. (PubMed id 23532874)¹ Maximov V.V....Tarantul V.Z. (J. Pept. Sci. 2013)

External Searches for MPHOSPH8 gene

Genome Databases showing MPHOSPH8 gene

Other Databases showing MPHOSPH8 gene

Specialized Databases showing MPHOSPH8 gene

Products
for MPHOSPH8 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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