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MPHOSPH6 Gene

protein-coding   GIFtS: 60
GCID: GC16M082181

M-Phase Phosphoprotein 6

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
M-Phase Phosphoprotein 61 2
MPP62 3
MPP2 5
MPP-62

External Ids:    HGNC: 72141   Entrez Gene: 102002   Ensembl: ENSG000001356987   OMIM: 6055005   UniProtKB: Q995473   
ORGUL members:         

Export aliases for MPHOSPH6 gene to outside databases

Previous GC identifers: GC16M073023 GC16M083142 GC16M081920 GC16M081961 GC16M080739 GC16M067936


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MPHOSPH6 Gene:
MPHOSPH6 (M-phase phosphoprotein 6) is a protein-coding gene. Diseases associated with MPHOSPH6 include obesity, and hiv-1. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: MPH6_HUMAN, Q99547
Function: RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the
7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this
function may include C1D

Gene Wiki entry for MPHOSPH6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MPHOSPH6
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMPHOSPH6 promoter sequence
   Search Chromatin IP Primers for MPHOSPH6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MPHOSPH6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.3   Ensembl cytogenetic band:  16q23.3   HGNC cytogenetic band: 16q23.3

MPHOSPH6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPHOSPH6 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M082181:  view genomic region     (about GC identifiers)

Start:
82,181,403 bp from pter      End:
82,203,831 bp from pter
Size:
22,429 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MPH6_HUMAN, Q99547 (See protein sequence)
Recommended Name: M-phase phosphoprotein 6  
Size: 160 amino acids; 19024 Da
Subunit: Associates with the RNA exosome complex, probably mediated by EXOSC10. Interacts with ARHGAP18, EXOSC10
and SKIV2L2
Secondary accessions: B2RAF0

Explore the universe of human proteins at neXtProt for MPHOSPH6: NX_Q99547

Explore proteomics data for MPHOSPH6 at MOPED

Post-translational modifications: 

  • Phosphorylated in M (mitotic) phase1
  • Ubiquitination2 at Lys86
  • Modification sites at PhosphoSitePlus

  • See MPHOSPH6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005783.2  
    ENSEMBL proteins: 
     ENSP00000454996   ENSP00000258169   ENSP00000456626   ENSP00000457537   ENSP00000454900  

    MPHOSPH6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for MPHOSPH6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019324 MPP6

    Graphical View of Domain Structure for InterPro Entry Q99547

    ProtoNet protein and cluster: Q99547

    UniProtKB/Swiss-Prot: MPH6_HUMAN, Q99547
    Similarity: Belongs to the MPP6 family


    MPHOSPH6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPH6_HUMAN, Q99547
    Function: RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the
    7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this
    function may include C1D

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI11719186
         
    MPHOSPH6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MPHOSPH6:
     Decreased Tat-dependent transc  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MPHOSPH6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MPHOSPH6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MPHOSPH6

    miRNA
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    miRTarBase miRNAs that target MPHOSPH6:
    hsa-mir-25-3p (MIRT050347), hsa-mir-197-3p (MIRT048065)

    Block miRNA regulation of human, mouse, rat MPHOSPH6 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MPHOSPH6:
    hsa-miR-1265
    SwitchGear 3'UTR luciferase reporter plasmidMPHOSPH6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MPHOSPH6
    Predesigned siRNA for gene silencing in human, mouse, rat MPHOSPH6

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: MPHOSPH6 (NM_005792)
    Sino Biological Human cDNA Clone for MPHOSPH6
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPHOSPH6

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPHOSPH6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MPH6_HUMAN, Q99547: Nucleus, nucleolus. Cytoplasm. Note=Cytoplasmic in M phase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000176colocalizes with nuclear exosome (RNase complex) TAS11719186
    GO:0000178colocalizes with exosome (RNase complex) IDA11719186
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    MPHOSPH6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MPHOSPH6 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    RNA degradation0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MPHOSPH6
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions



    1 Kegg Pathway  (Kegg details for MPHOSPH6):
        RNA degradation


    MPHOSPH6 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MPHOSPH6
    Interactions:

        Search GeneGlobe Interaction Network for MPHOSPH6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MPHOSPH6 (Q995471, 2, 3 ENSP000002581694) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKIV2L2P422851, 3, ENSP000002306404EBI-373187,EBI-347612 I2D: score=3 STRING: ENSP00000230640
    APLP1P516932, 3MINT-65273 I2D: score=5 
    C14orf1Q9UKR52, 3MINT-65278 I2D: score=5 
    GDF9O603832, 3MINT-65271 I2D: score=5 
    TP53P046372, 3MINT-65272 I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000087mitotic M phase TAS8885239
    GO:0000460maturation of 5.8S rRNA IMP17412707

    MPHOSPH6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MPHOSPH6 (MPH6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MPHOSPH6 gene: 
    NM_005792.2  

    Unigene Cluster for MPHOSPH6:

    M-phase phosphoprotein 6
    Hs.344400  [show with all ESTs]
    Unigene Representative Sequence: BX537773
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000563100 ENST00000258169(uc002fgw.3) ENST00000563504 ENST00000568016
    ENST00000569599 ENST00000566748 ENST00000569021 ENST00000567729

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MPHOSPH6 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MPHOSPH6:
    hsa-miR-1265
    SwitchGear 3'UTR luciferase reporter plasmidMPHOSPH6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MPHOSPH6
    Predesigned siRNA for gene silencing in human, mouse, rat MPHOSPH6
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MPHOSPH6 (NM_005792)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPHOSPH6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPHOSPH6
    Primer
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    OriGene qPCR primer pairs and template standards for MPHOSPH6
    OriGene qSTAR qPCR primer pairs in human, mouse for MPHOSPH6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MPHOSPH6
      QuantiTect SYBR Green Assays in human, mouse, rat MPHOSPH6
      QuantiFast Probe-based Assays in human, mouse, rat MPHOSPH6

    Additional mRNA sequence: 

    AK222667.1 AK314163.1 BC005242.1 BC011020.1 BC029395.1 BC031017.1 BX537773.1 X98263.1 

    13 DOTS entries:

    DT.115950  DT.95091903  DT.100774055  DT.91748625  DT.120690833  DT.40123368  DT.426581  DT.100774042 
    DT.100774054  DT.101968302  DT.91746759  DT.99985608  DT.91727098 

    Selected AceView cDNA sequences (see all 175):

    AW149091 AI379304 AA476760 AI831131 CR611170 CD677695 CA441038 AA626333 
    AA694019 AA703558 BU622913 BE047811 AI473364 AW244131 BM970535 AI032537 
    BQ011148 CF528512 W86550 AI248862 BU629926 CK429207 BG751725 BF512849 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MPHOSPH6 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:                    -     -     -                 -     -           -     -                                 
    SP2:                    -           -                 -                                                         
    SP3:                                -                 -     -           -     -                                 
    SP4:                                                  -     -           -     -                                 
    SP5:                                            -     -     -           -     -                                 


    ECgene alternative splicing isoforms for MPHOSPH6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MPHOSPH6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCCAGGTC
    MPHOSPH6 Expression
    About this image


    MPHOSPH6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    MPHOSPH6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MPHOSPH6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.344400
        Custom PCR Arrays for MPHOSPH6
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    QuantiFast Probe-based Assays in human, mouse, rat MPHOSPH6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPHOSPH6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MPHOSPH6 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mphosph61 , 5 M phase phosphoprotein 61, 5 82.71(n)1
    87.5(a)1
      8 (65.09 cM)5
    685331  NM_026758.31  NP_081034.11 
     1177916455 
    chicken
    (Gallus gallus)
    Aves MPHOSPH61 M-phase phosphoprotein 6 76.67(n)
    76.87(a)
      415811  NM_001277139.1  NP_001264068.1 
    lizard
    (Anolis carolinensis)
    Reptilia MPHOSPH66
    M-phase phosphoprotein 6
    65(a)
    1 ↔ 1
    GL343663.1(16846-24313)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.73222 Xenopus laevis transcribed sequence with moderate similarity more 77.31(n)    AW636952.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.157572 Transcribed sequence with weak similarity to protein more 76.27(n)    AL719826.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mpp66
    M-phase phosphoprotein 6
    32(a)
    1 ↔ 1
    2L(21156874-21157685)


    ENSEMBL Gene Tree for MPHOSPH6 (if available)
    TreeFam Gene Tree for MPHOSPH6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MPHOSPH6 gene

    MPHOSPH6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MPHOSPH6
    PGOHUM00000262414


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MPHOSPH6 (see all 887)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs99297021,2
    C,F--82181316(+) gtcctA/Gtcttt 1 -- ds50014Minor allele frequency- G:0.34WA CSA 123
    rs124487851,2
    C,F,H--82181402(+) ATGTAC/GCTCAT 1 -- ds50017Minor allele frequency- G:0.14NS NA WA EA 480
    rs99396651,2
    C,F--82181403(+) TGTACC/TTCATT 1 -- ds50011Minor allele frequency- T:0.10WA 118
    rs1390669481,2
    --82181423(+) GGAGCA/GAAATT 1 -- ds50010--------
    rs124460301,2
    C,F,H--82181505(+) ATTCTA/GTGTGC 1 -- ds50017Minor allele frequency- G:0.21NA EA 386
    rs788571141,2
    F--82181563(+) TACCAT/CTGGTC 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1863298931,2
    --82181573(+) CAGTGA/GTAAAT 1 -- ds50010--------
    rs124486721,2
    C,F,A,H--82181582(+) ATTCTG/ATTGGG 1 -- ds500123Minor allele frequency- A:0.18NS EA NA WA 2768
    rs1896089991,2
    --82181595(+) ATACCA/GTAAGA 1 -- ds50010--------
    rs99392181,2
    C,F,H--82181608(+) ctaaaG/Agttat 1 -- ds50019Minor allele frequency- A:0.07NS EA NA WA 1118

    HapMap Linkage Disequilibrium report for MPHOSPH6 (82181403 - 82203831 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MPHOSPH6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518129CNV Loss19592680
    nsv907015CNV Loss21882294
    nsv525467CNV Loss19592680
    nsv833302CNV Loss17160897
    nsv907013CNV Gain21882294
    esv7218CNV Gain19470904
    nsv907014CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MPHOSPH6
    DNA2.0 Custom Variant and Variant Library Synthesis for MPHOSPH6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605500    OMIM disorders: --

    2 diseases for MPHOSPH6:    
    About MalaCards
    obesity    hiv-1


    MPHOSPH6 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): MPHOSPH6
    Human Genome Epidemiology (HuGE) Navigator: MPHOSPH6 (2 documents)

    Export disorders for MPHOSPH6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MPHOSPH6 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with MPHOSPH6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel M phase phosphoproteins by expression cloning. (PubMed id 8885239)1, 2, 3 Matsumoto-Taniura N....Westendorf J.M. (Mol. Biol. Cell 1996)
    2. MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation. (PubMed id 16396833)1, 2, 9 Schilders G.... Pruijn G.J. (Nucleic Acids Res. 2005)
    3. Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PubMed id 20531389)1, 2 Staals R.H.... Pruijn G.J. (EMBO J. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing. (PubMed id 17412707)1, 2 Schilders G.... Pruijn G.J.M. (Nucleic Acids Res. 2007)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1, 2 Lehner B. and Sanderson C.M. (Genome Res. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. (PubMed id 11719186)1, 2 Chen C.-Y.... Karin M. (Cell 2001)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10200 HGNC: 7214 AceView: MPHOSPH6 Ensembl:ENSG00000135698 euGenes: HUgn10200
    ECgene: MPHOSPH6 Kegg: 10200 H-InvDB: MPHOSPH6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MPHOSPH6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MPHOSPH6 gene:
    Search GeneIP for patents involving MPHOSPH6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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