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Aliases for MPHOSPH6 Gene

Aliases for MPHOSPH6 Gene

  • M-Phase Phosphoprotein 6 2 3
  • MPP6 3 4
  • MPP 3 6
  • MPP-6 3

External Ids for MPHOSPH6 Gene

Summaries for MPHOSPH6 Gene

GeneCards Summary for MPHOSPH6 Gene

MPHOSPH6 (M-Phase Phosphoprotein 6) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for MPHOSPH6 Gene

  • RNA-binding protein that associates with the RNA exosome complex. Involved in the 3-processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D.

Gene Wiki entry for MPHOSPH6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPHOSPH6 Gene

Genomics for MPHOSPH6 Gene

Genomic Location for MPHOSPH6 Gene

Start:
82,147,798 bp from pter
End:
82,170,226 bp from pter
Size:
22,429 bases
Orientation:
Minus strand

Genomic View for MPHOSPH6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPHOSPH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPHOSPH6 Gene

No data available for Regulatory Elements for MPHOSPH6 Gene

Proteins for MPHOSPH6 Gene

  • Protein details for MPHOSPH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99547-MPH6_HUMAN
    Recommended name:
    M-phase phosphoprotein 6
    Protein Accession:
    Q99547
    Secondary Accessions:
    • B2RAF0

    Protein attributes for MPHOSPH6 Gene

    Size:
    160 amino acids
    Molecular mass:
    19024 Da
    Quaternary structure:
    • Associates with the RNA exosome complex, probably mediated by EXOSC10. Interacts with ARHGAP18, EXOSC10 and SKIV2L2.

neXtProt entry for MPHOSPH6 Gene

Proteomics data for MPHOSPH6 Gene at MOPED

Post-translational modifications for MPHOSPH6 Gene

Other Protein References for MPHOSPH6 Gene

No data available for DME Specific Peptides for MPHOSPH6 Gene

Domains for MPHOSPH6 Gene

Protein Domains for MPHOSPH6 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MPH6_HUMAN
Family:
  • Belongs to the MPP6 family.:
    • Q99547
genes like me logo Genes that share domains with MPHOSPH6: view

No data available for Gene Families for MPHOSPH6 Gene

Function for MPHOSPH6 Gene

Molecular function for MPHOSPH6 Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein that associates with the RNA exosome complex. Involved in the 3-processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D.

Gene Ontology (GO) - Molecular Function for MPHOSPH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 11719186
genes like me logo Genes that share ontologies with MPHOSPH6: view

Phenotypes for MPHOSPH6 Gene

GenomeRNAi human phenotypes for MPHOSPH6:
genes like me logo Genes that share phenotypes with MPHOSPH6: view

miRNA for MPHOSPH6 Gene

miRTarBase miRNAs that target MPHOSPH6

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MPHOSPH6 Gene

Localization for MPHOSPH6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPHOSPH6 Gene

Nucleus, nucleolus. Cytoplasm. Note=Cytoplasmic in M phase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MPHOSPH6 Gene COMPARTMENTS Subcellular localization image for MPHOSPH6 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MPHOSPH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000176 colocalizes_with nuclear exosome (RNase complex) TAS 11719186
GO:0000178 colocalizes_with exosome (RNase complex) IDA 11719186
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MPHOSPH6: view

Pathways for MPHOSPH6 Gene

genes like me logo Genes that share pathways with MPHOSPH6: view

Pathways by source for MPHOSPH6 Gene

1 KEGG pathway for MPHOSPH6 Gene

Gene Ontology (GO) - Biological Process for MPHOSPH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000460 maturation of 5.8S rRNA IMP 17412707
genes like me logo Genes that share ontologies with MPHOSPH6: view

Transcripts for MPHOSPH6 Gene

Unigene Clusters for MPHOSPH6 Gene

M-phase phosphoprotein 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MPHOSPH6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - -

Relevant External Links for MPHOSPH6 Gene

GeneLoc Exon Structure for
MPHOSPH6
ECgene alternative splicing isoforms for
MPHOSPH6

Expression for MPHOSPH6 Gene

mRNA expression in normal human tissues for MPHOSPH6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPHOSPH6 Gene

SOURCE GeneReport for Unigene cluster for MPHOSPH6 Gene Hs.344400

genes like me logo Genes that share expressions with MPHOSPH6: view

Orthologs for MPHOSPH6 Gene

This gene was present in the common ancestor of animals.

Orthologs for MPHOSPH6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MPHOSPH6 36
  • 98.96 (n)
  • 98.75 (a)
MPHOSPH6 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MPHOSPH6 36
  • 92.92 (n)
  • 93.75 (a)
MPHOSPH6 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MPHOSPH6 36
  • 91.67 (n)
  • 91.87 (a)
MPHOSPH6 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mphosph6 36
  • 82.71 (n)
  • 87.5 (a)
Mphosph6 16
Mphosph6 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MPHOSPH6 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MPHOSPH6 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mphosph6 36
  • 83.54 (n)
  • 88.12 (a)
chicken
(Gallus gallus)
Aves MPHOSPH6 36
  • 76.67 (n)
  • 76.87 (a)
MPHOSPH6 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MPHOSPH6 37
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7322 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mphosph6 36
  • 72.12 (n)
  • 73.58 (a)
Str.6419 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11235 36
zebrafish
(Danio rerio)
Actinopterygii Dr.15757 36
mphosph6 36
  • 66.04 (n)
  • 65.62 (a)
mphosph6 37
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mpp6 37
  • 32 (a)
OneToOne
Species with no ortholog for MPHOSPH6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPHOSPH6 Gene

ENSEMBL:
Gene Tree for MPHOSPH6 (if available)
TreeFam:
Gene Tree for MPHOSPH6 (if available)

Paralogs for MPHOSPH6 Gene

Pseudogenes.org Pseudogenes for MPHOSPH6 Gene

genes like me logo Genes that share paralogs with MPHOSPH6: view

No data available for Paralogs for MPHOSPH6 Gene

Variants for MPHOSPH6 Gene

Sequence variations from dbSNP and Humsavar for MPHOSPH6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs725953 -- 82,158,557(-) CACAA(A/G)TGCAG intron-variant
rs1056629 -- 82,148,499(-) TGTAC(A/G)TTGTT utr-variant-3-prime
rs1056654 -- 82,148,406(-) ATAAA(C/T)TACTG utr-variant-3-prime
rs1056675 -- 82,148,329(-) ATCAA(A/G)TGTCA utr-variant-3-prime
rs1056690 -- 82,148,193(+) AGCAA(A/T)TTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MPHOSPH6 Gene

Variant ID Type Subtype PubMed ID
nsv907013 CNV Gain 21882294
nsv525467 CNV Loss 19592680
nsv907014 CNV Gain 21882294
nsv518129 CNV Loss 19592680
nsv833302 CNV Loss 17160897
esv7218 CNV Gain 19470904
nsv907015 CNV Loss 21882294

Relevant External Links for MPHOSPH6 Gene

HapMap Linkage Disequilibrium report
MPHOSPH6

Disorders for MPHOSPH6 Gene

Relevant External Links for MPHOSPH6

Genetic Association Database (GAD)
MPHOSPH6
Human Genome Epidemiology (HuGE) Navigator
MPHOSPH6
genes like me logo Genes that share disorders with MPHOSPH6: view

No data available for UniProtKB/Swiss-Prot for MPHOSPH6 Gene

Publications for MPHOSPH6 Gene

  1. MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation. (PMID: 16396833) Schilders G. … Pruijn G.J. (Nucleic Acids Res. 2005) 3 4 23
  2. Identification of novel M phase phosphoproteins by expression cloning. (PMID: 8885239) Matsumoto-Taniura N. … Westendorf J.M. (Mol. Biol. Cell 1996) 2 3 4
  3. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. (PMID: 11719186) Chen C.-Y. … Karin M. (Cell 2001) 3 4
  4. A protein interaction framework for human mRNA degradation. (PMID: 15231747) Lehner B. … Sanderson C.M. (Genome Res. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MPHOSPH6 Gene

Sources for MPHOSPH6 Gene

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