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MPHOSPH10 Gene

protein-coding   GIFtS: 58
GCID: GC02P071358

M-Phase Phosphoprotein 10 (U3 Small Nucleolar Ribonucleoprotein)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
M-Phase Phosphoprotein 10 (U3 Small Nucleolar Ribonucleoprotein)1 2
M Phase Phosphoprotein 102 3
MPP102 3
CT902
MPP10P2
U3 Small Nucleolar Ribonucleoprotein Protein MPP102

External Ids:    HGNC: 72131   Entrez Gene: 101992   Ensembl: ENSG000001243837   OMIM: 6055035   UniProtKB: O005663   

Export aliases for MPHOSPH10 gene to outside databases

Previous GC identifers: GC02P071366 GC02P071569 GC02P071331 GC02P071269 GC02P071210 GC02P071094


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MPHOSPH10 Gene:
This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during
interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar
ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing. (provided by RefSeq, Dec 2010)

GeneCards Summary for MPHOSPH10 Gene:
MPHOSPH10 (M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)) is a protein-coding gene. Diseases associated with MPHOSPH10 include scleroderma, and hypoxia.

UniProtKB/Swiss-Prot: MPP10_HUMAN, O00566
Function: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early
cleavages during pre-18S ribosomal RNA processing

Gene Wiki entry for MPHOSPH10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MPHOSPH10 gene promoter:
         HOXA9   HOXA9B   C/EBPbeta   RFX1   HOXA3   Nkx5-1   C/EBPalpha   IRF-2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMPHOSPH10 promoter sequence
   Search Chromatin IP Primers for MPHOSPH10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MPHOSPH10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.3   Ensembl cytogenetic band:  2p13.3   HGNC cytogenetic band: 2p13.3

MPHOSPH10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPHOSPH10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P071358:  view genomic region     (about GC identifiers)

Start:
71,357,444 bp from pter      End:
71,377,232 bp from pter
Size:
19,789 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MPP10_HUMAN, O00566 (See protein sequence)
Recommended Name: U3 small nucleolar ribonucleoprotein protein MPP10  
Size: 681 amino acids; 78864 Da
Subunit: Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with IMP3 and IMP4
Secondary accessions: A0AVJ8

Explore the universe of human proteins at neXtProt for MPHOSPH10: NX_O00566

Explore proteomics data for MPHOSPH10 at MOPED

Post-translational modifications: 

  • Phosphorylated in M (mitotic) phase1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MPHOSPH10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005782.1  
    ENSEMBL proteins: 
     ENSP00000244230   ENSP00000475545  

    MPHOSPH10 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for MPHOSPH10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR012173 snoRNP_Mpp10
     IPR007151 Mpp10

    Graphical View of Domain Structure for InterPro Entry O00566

    ProtoNet protein and cluster: O00566

    1 Blocks protein domain: IPB007151 Mpp10 protein

    UniProtKB/Swiss-Prot: MPP10_HUMAN, O00566
    Similarity: Belongs to the MPP10 family


    MPHOSPH10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPP10_HUMAN, O00566
    Function: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early
    cleavages during pre-18S ribosomal RNA processing

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12655004
    GO:0044822poly(A) RNA binding IDA--
         
    MPHOSPH10 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MPHOSPH10:
     Nuclear 40S maturation defects  Nucleolar pre-40S maturation d  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MPHOSPH10
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MPHOSPH10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MPHOSPH10

    miRNA
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    miRTarBase miRNAs that target MPHOSPH10:
    hsa-mir-124-3p (MIRT023055), hsa-mir-92b-3p (MIRT040675)

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPHOSPH10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MPP10_HUMAN, O00566: Nucleus, nucleolus. Chromosome. Note=Fibrillar region of the nucleolus. After dissolution of
    the nucleolus in early M phase becomes associated with chromosomes through metaphase and anaphase. In telophase
    localized to small cellular prenucleolar bodies that not always contain fibrillarin. The reassociation with
    nucleolus is preceeded by the arrival of fibrillarin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005694chromosome IEA--
    GO:0005730nucleolus IDA--
    GO:0005732small nucleolar ribonucleoprotein complex NAS9450966
    GO:0030529ribonucleoprotein complex ----

    MPHOSPH10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MPHOSPH10 About    
    See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for MPHOSPH10):
        Ribosome biogenesis in eukaryotes


    MPHOSPH10 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MPHOSPH10
    Interactions:

        GeneGlobe Interaction Network for MPHOSPH10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MPHOSPH10 (O005661, 2, 3 ENSP000002442304) via UniProtKB, MINT, STRING, and/or I2D (see all 129)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAP621361, 2, 3, ENSP000003260314EBI-5235884,EBI-357253 MINT-62204 I2D: score=2 STRING: ENSP00000326031
    IMP3Q9NV313, ENSP000003269814I2D: score=2 STRING: ENSP00000326981
    IMP4Q96G213, ENSP000002592394I2D: score=3 STRING: ENSP00000259239
    PRKAA1Q131313I2D: score=1 
    HEATR1ENSP000003555414STRING: ENSP00000355541
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000375RNA splicing, via transesterification reactions NAS9450966
    GO:0006364rRNA processing IEA--
    GO:0006396RNA processing NAS9450966
    GO:0008380RNA splicing NAS9450966
    GO:0010923negative regulation of phosphatase activity IDA19389623

    MPHOSPH10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MPHOSPH10 (MPP10)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MPHOSPH10 gene: 
    NM_005791.2  

    Unigene Cluster for MPHOSPH10:

    M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
    Hs.656208  [show with all ESTs]
    Unigene Representative Sequence: NM_005791
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000244230(uc002sht.2) ENST00000498451(uc010feb.1) ENST00000468427
    ENST00000476969 ENST00000493360
    miRNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MPHOSPH10 (NM_005791)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPHOSPH10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPHOSPH10
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MPHOSPH10
      QuantiTect SYBR Green Assays in human, mouse, rat MPHOSPH10
      QuantiFast Probe-based Assays in human, mouse, rat MPHOSPH10

    Additional mRNA sequence: 

    AK056862.1 AK310931.1 BC015158.2 BC041084.1 BC126389.1 X98494.1 

    9 DOTS entries:

    DT.414708  DT.121001129  DT.99999223  DT.92428483  DT.92428485  DT.40110724  DT.40207422  DT.121001134 
    DT.91909728 

    Selected AceView cDNA sequences (see all 143):

    BC015158 W80758 C02251 BM833903 NM_005791 BQ021283 CA418486 AI284853 
    BQ021715 BQ233445 CA412550 CA423937 CR590410 BM142707 BM263134 BQ775970 
    BM974527 BC041084 CA313569 X98494 BQ775550 CA428731 AV731318 AI760199 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MPHOSPH10 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12
    SP1:                                                                          -                                       
    SP2:                                                                                                                  
    SP3:                                                                                            -                     
    SP4:                                                                                                                  
    SP5:              -                                                                                                   


    ECgene alternative splicing isoforms for MPHOSPH10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MPHOSPH10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGAAGTAG
    MPHOSPH10 Expression
    About this image

    MPHOSPH10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MPHOSPH10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656208
        Custom PCR Arrays for MPHOSPH10
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MPHOSPH10 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mphosph101 , 5 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)1, 5 83.53(n)1
    81.56(a)1
      7 (34.64 cM)5
    679731  NM_026483.21  NP_080759.21 
     643765765 
    chicken
    (Gallus gallus)
    Aves MPHOSPH101 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 68.15(n)
    63.96(a)
      415384  XM_413769.4  XP_413769.3 
    lizard
    (Anolis carolinensis)
    Reptilia MPHOSPH106
    M-phase phosphoprotein 10 (U3 small nucleolar ribo...
    58(a)
    1 ↔ 1
    GL343428.1(17370-28806)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985242 hypothetical protein LOC398524 77.64(n)    BC045231.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mphosph102 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 76.79(n)   323426  BC049436.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG130973   -- 49(a)   29D3   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y75B8A.73   -- 34(a)   III(12224559-12231241)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MPP10(YJR002W)4 Component of the SSU processome and 90S preribosome, more   --   10(438865-440646) 853458  NP_012535.1 


    ENSEMBL Gene Tree for MPHOSPH10 (if available)
    TreeFam Gene Tree for MPHOSPH10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MPHOSPH10 gene

    MPHOSPH10 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for MPHOSPH10 (see all 11)
    PGOHUM00000258806 PGOHUM00000258814 PGOHUM00000258818 PGOHUM00000258823 PGOHUM00000256745


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MPHOSPH10 (see all 458)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1176594731,2
    F--71359506(+) CCTTCA/GCACTC 1 -- int11Minor allele frequency- G:0.03EA 120
    rs1457367341,2
    --71359562(+) TTTGCA/GTCTTA 1 -- int10--------
    rs1894945321,2
    --71359568(+) TCTTAC/GAGGAT 1 -- int10--------
    rs791371201,2
    C,F--71359610(+) TTTATA/GAGACT 1 -- int12Minor allele frequency- G:0.03WA NA 238
    rs770744901,2
    F--71359705(+) ATTGAA/GTGAAT 1 -- int11Minor allele frequency- G:0.03NA 120
    rs1156039091,2
    F--71359718(+) GTGAAC/TAAATG 1 -- int11Minor allele frequency- T:0.01NA 120
    rs729055031,2
    C,F--71359832(+) CAGCCG/AATTCA 1 -- int12Minor allele frequency- A:0.15WA 120
    rs1401780971,2
    C--71359953(+) TTGGG-/TTTTTT 1 -- int10--------
    rs2005712511,2
    --71360042(+) GGGATC/TGGCAT 2 S L mis10--------
    rs1387230531,2
    C,F--71360060(+) CACTTC/ATTTAA 2 /Y /S mis11Minor allele frequency- A:0.00EU 1151

    HapMap Linkage Disequilibrium report for MPHOSPH10 (71357444 - 71377232 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MPHOSPH10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720185CNV Deletion23290073
    esv2662403CNV Deletion23128226
    nsv2771CNV Loss18451855
    nsv508148CNV Loss20534489
    nsv874254CNV Loss21882294
    nsv874253CNV Gain21882294
    nsv834256CNV Gain17160897
    dgv1196e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605503    OMIM disorders: --

    6 diseases for MPHOSPH10:    
    About MalaCards
    scleroderma    hypoxia    neuroblastoma    malaria
    multiple myeloma    myeloma


    MPHOSPH10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MPHOSPH10

    Export disorders for MPHOSPH10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MPHOSPH10 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with MPHOSPH10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. M phase phosphoprotein 10 is a human U3 small nucleolar ribonucleoprotein component. (PubMed id 9450966)1, 2, 3, 9 Westendorf J.M....Baserga S.J. (Mol. Biol. Cell 1998)
    2. Identification of novel M phase phosphoproteins by expression cloning. (PubMed id 8885239)1, 2, 3 Matsumoto-Taniura N....Westendorf J.M. (Mol. Biol. Cell 1996)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. (PubMed id 12655004)1, 2 Granneman S.... Pruijn G.J.M. (Nucleic Acids Res. 2003)
    6. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    9. Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. (PubMed id 22751105)1 Chu L....Tomasson M.H. (J. Clin. Invest. 2012)
    10. A bead-based approach for large-scale identification of in vitro kinase substrates. (PubMed id 22113938)1 Zhang M....Zou H. (Proteomics 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10199 HGNC: 7213 AceView: MPHOSPH10 Ensembl:ENSG00000124383 euGenes: HUgn10199
    ECgene: MPHOSPH10 Kegg: 10199 H-InvDB: MPHOSPH10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MPHOSPH10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MPHOSPH10 gene:
    Search GeneIP for patents involving MPHOSPH10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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