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Aliases for MPHOSPH10 Gene

Aliases for MPHOSPH10 Gene

  • M-Phase Phosphoprotein 10 2 3
  • M-Phase Phosphoprotein 10 (U3 Small Nucleolar Ribonucleoprotein) 2 3 5
  • U3 Small Nucleolar Ribonucleoprotein 2 3
  • M Phase Phosphoprotein 10 3 4
  • MPP10 3 4
  • Protein Phosphatase 1, Regulatory Subunit 106 3
  • Regulatory Subunit 106 2
  • Protein Phosphatase 1 2
  • PPP1R106 3
  • MPP10P 3
  • CT90 3

External Ids for MPHOSPH10 Gene

Previous GeneCards Identifiers for MPHOSPH10 Gene

  • GC02P071366
  • GC02P071569
  • GC02P071331
  • GC02P071269
  • GC02P071210
  • GC02P071358
  • GC02P071094

Summaries for MPHOSPH10 Gene

Entrez Gene Summary for MPHOSPH10 Gene

  • This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing. [provided by RefSeq, Dec 2010]

GeneCards Summary for MPHOSPH10 Gene

MPHOSPH10 (M-Phase Phosphoprotein 10) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for MPHOSPH10 Gene

  • Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

Gene Wiki entry for MPHOSPH10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPHOSPH10 Gene

Genomics for MPHOSPH10 Gene

Regulatory Elements for MPHOSPH10 Gene

Enhancers for MPHOSPH10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MPHOSPH10 on UCSC Golden Path with GeneCards custom track

Promoters for MPHOSPH10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MPHOSPH10 on UCSC Golden Path with GeneCards custom track

Genomic Location for MPHOSPH10 Gene

71,130,314 bp from pter
71,150,102 bp from pter
19,789 bases
Plus strand

Genomic View for MPHOSPH10 Gene

Genes around MPHOSPH10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPHOSPH10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPHOSPH10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPHOSPH10 Gene

Proteins for MPHOSPH10 Gene

  • Protein details for MPHOSPH10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U3 small nucleolar ribonucleoprotein protein MPP10
    Protein Accession:
    Secondary Accessions:
    • A0AVJ8

    Protein attributes for MPHOSPH10 Gene

    681 amino acids
    Molecular mass:
    78864 Da
    Quaternary structure:
    • Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with IMP3 and IMP4.

neXtProt entry for MPHOSPH10 Gene

Proteomics data for MPHOSPH10 Gene at MOPED

Post-translational modifications for MPHOSPH10 Gene

Other Protein References for MPHOSPH10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MPHOSPH10 Gene

Domains & Families for MPHOSPH10 Gene

Gene Families for MPHOSPH10 Gene

Protein Domains for MPHOSPH10 Gene


Suggested Antigen Peptide Sequences for MPHOSPH10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MPP10 family.
  • Belongs to the MPP10 family.
genes like me logo Genes that share domains with MPHOSPH10: view

Function for MPHOSPH10 Gene

Molecular function for MPHOSPH10 Gene

UniProtKB/Swiss-Prot Function:
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
genes like me logo Genes that share phenotypes with MPHOSPH10: view

Animal Model Products

CRISPR Products

miRNA for MPHOSPH10 Gene

miRTarBase miRNAs that target MPHOSPH10

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPHOSPH10 Gene

Localization for MPHOSPH10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPHOSPH10 Gene

Nucleus, nucleolus. Chromosome. Note=Fibrillar region of the nucleolus (PubMed:9450966). After dissolution of the nucleolus in early M phase becomes associated with chromosomes through metaphase and anaphase (PubMed:9450966). In telophase localized to small cellular prenucleolar bodies that not always contain fibrillarin (PubMed:9450966). The reassociation with nucleolus is preceeded by the arrival of fibrillarin (PubMed:9450966). {ECO:0000269 PubMed:9450966}.

Subcellular locations from

Jensen Localization Image for MPHOSPH10 Gene COMPARTMENTS Subcellular localization image for MPHOSPH10 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MPHOSPH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0032040 small-subunit processome IBA --
genes like me logo Genes that share ontologies with MPHOSPH10: view

Pathways & Interactions for MPHOSPH10 Gene

genes like me logo Genes that share pathways with MPHOSPH10: view

Pathways by source for MPHOSPH10 Gene

Gene Ontology (GO) - Biological Process for MPHOSPH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000375 RNA splicing, via transesterification reactions NAS 9450966
GO:0006364 rRNA processing IEA,TAS --
GO:0008380 RNA splicing NAS 9450966
genes like me logo Genes that share ontologies with MPHOSPH10: view

No data available for SIGNOR curated interactions for MPHOSPH10 Gene

Drugs & Compounds for MPHOSPH10 Gene

No Compound Related Data Available

Transcripts for MPHOSPH10 Gene

Unigene Clusters for MPHOSPH10 Gene

M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MPHOSPH10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12
SP1: -
SP3: -
SP5: -

Relevant External Links for MPHOSPH10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPHOSPH10 Gene

mRNA expression in normal human tissues for MPHOSPH10 Gene

Protein differential expression in normal tissues from HIPED for MPHOSPH10 Gene

This gene is overexpressed in Heart (10.5), Peripheral blood mononuclear cells (10.4), Blymphocyte (8.5), Lung (7.4), and CD8 Tcells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPHOSPH10 Gene

SOURCE GeneReport for Unigene cluster for MPHOSPH10 Gene Hs.656208

genes like me logo Genes that share expression patterns with MPHOSPH10: view

Protein tissue co-expression partners for MPHOSPH10 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MPHOSPH10 Gene

Orthologs for MPHOSPH10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MPHOSPH10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MPHOSPH10 35
  • 86.07 (n)
  • 85.93 (a)
  • 85 (a)
(Canis familiaris)
Mammalia MPHOSPH10 35
  • 87.95 (n)
  • 85.63 (a)
  • 86 (a)
(Mus musculus)
Mammalia Mphosph10 35
  • 83.53 (n)
  • 81.56 (a)
Mphosph10 16
Mphosph10 36
  • 82 (a)
(Pan troglodytes)
Mammalia MPHOSPH10 35
  • 99.56 (n)
  • 98.97 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Mphosph10 35
  • 82.44 (n)
  • 79.82 (a)
(Monodelphis domestica)
Mammalia MPHOSPH10 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia MPHOSPH10 36
  • 44 (a)
(Gallus gallus)
Aves MPHOSPH10 35
  • 68.15 (n)
  • 63.96 (a)
  • 61 (a)
(Anolis carolinensis)
Reptilia MPHOSPH10 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mphosph10 35
  • 66.02 (n)
  • 61.22 (a)
Str.16216 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398524 35
(Danio rerio)
Actinopterygii mphosph10 35
  • 61.78 (n)
  • 57.55 (a)
mphosph10 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13097 37
  • 49 (a)
CG13097 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea Y75B8A.7 37
  • 34 (a)
Y75B8A.7 36
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MPP10 36
  • 26 (a)
MPP10 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3443 36
  • 48 (a)
Species with no ortholog for MPHOSPH10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPHOSPH10 Gene

Gene Tree for MPHOSPH10 (if available)
Gene Tree for MPHOSPH10 (if available)

Paralogs for MPHOSPH10 Gene

genes like me logo Genes that share paralogs with MPHOSPH10: view

No data available for Paralogs for MPHOSPH10 Gene

Variants for MPHOSPH10 Gene

Sequence variations from dbSNP and Humsavar for MPHOSPH10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6574 - 71,149,869(-) ACCTT(C/T)ATCCT reference, missense
rs3732240 - 71,139,827(-) TTCCA(G/T)TTGAA reference, missense
rs1813160 - 71,133,495(-) TCCTC(A/C)TCATC reference, missense
rs10199088 - 71,133,014(+) GATAG(A/C)AAATT reference, missense
rs13010513 - 71,133,152(+) GGAAC(A/G)TGAAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MPHOSPH10 Gene

Variant ID Type Subtype PubMed ID
nsv874253 CNV Gain 21882294
nsv834256 CNV Gain 17160897
esv2720185 CNV Deletion 23290073
esv2662403 CNV Deletion 23128226
nsv874254 CNV Loss 21882294
nsv2771 CNV Loss 18451855
dgv1196e1 CNV Complex 17122850
nsv508148 CNV Loss 20534489

Variation tolerance for MPHOSPH10 Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.66; 99.14% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MPHOSPH10 Gene

Disorders for MPHOSPH10 Gene

Relevant External Links for MPHOSPH10

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MPHOSPH10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPHOSPH10 Gene

Publications for MPHOSPH10 Gene

  1. M phase phosphoprotein 10 is a human U3 small nucleolar ribonucleoprotein component. (PMID: 9450966) Westendorf J.M. … Baserga S.J. (Mol. Biol. Cell 1998) 2 3 4 23 67
  2. Identification of novel M phase phosphoproteins by expression cloning. (PMID: 8885239) Matsumoto-Taniura N. … Westendorf J.M. (Mol. Biol. Cell 1996) 2 3
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for MPHOSPH10 Gene

Sources for MPHOSPH10 Gene