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Aliases for MPHOSPH10 Gene

Aliases for MPHOSPH10 Gene

  • M-Phase Phosphoprotein 10 (U3 Small Nucleolar Ribonucleoprotein) 2 3
  • M Phase Phosphoprotein 10 3 4
  • MPP10 3 4
  • U3 Small Nucleolar Ribonucleoprotein Protein MPP10 3
  • Protein Phosphatase 1, Regulatory Subunit 106 3
  • Regulatory Subunit 106 2
  • Protein Phosphatase 1 2
  • PPP1R106 3
  • MPP10P 3
  • CT90 3

External Ids for MPHOSPH10 Gene

Previous GeneCards Identifiers for MPHOSPH10 Gene

  • GC02P071366
  • GC02P071569
  • GC02P071331
  • GC02P071269
  • GC02P071210
  • GC02P071358
  • GC02P071094

Summaries for MPHOSPH10 Gene

Entrez Gene Summary for MPHOSPH10 Gene

  • This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing. [provided by RefSeq, Dec 2010]

GeneCards Summary for MPHOSPH10 Gene

MPHOSPH10 (M-Phase Phosphoprotein 10 (U3 Small Nucleolar Ribonucleoprotein)) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes.

UniProtKB/Swiss-Prot for MPHOSPH10 Gene

  • Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing

Gene Wiki entry for MPHOSPH10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPHOSPH10 Gene

Genomics for MPHOSPH10 Gene

Regulatory Elements for MPHOSPH10 Gene

Genomic Location for MPHOSPH10 Gene

Start:
71,130,314 bp from pter
End:
71,150,102 bp from pter
Size:
19,789 bases
Orientation:
Plus strand

Genomic View for MPHOSPH10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPHOSPH10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPHOSPH10 Gene

Proteins for MPHOSPH10 Gene

  • Protein details for MPHOSPH10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00566-MPP10_HUMAN
    Recommended name:
    U3 small nucleolar ribonucleoprotein protein MPP10
    Protein Accession:
    O00566
    Secondary Accessions:
    • A0AVJ8

    Protein attributes for MPHOSPH10 Gene

    Size:
    681 amino acids
    Molecular mass:
    78864 Da
    Quaternary structure:
    • Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with IMP3 and IMP4.

neXtProt entry for MPHOSPH10 Gene

Proteomics data for MPHOSPH10 Gene at MOPED

Post-translational modifications for MPHOSPH10 Gene

Other Protein References for MPHOSPH10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MPHOSPH10 Gene

Domains for MPHOSPH10 Gene

Protein Domains for MPHOSPH10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MPHOSPH10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00566

UniProtKB/Swiss-Prot:

MPP10_HUMAN :
  • O00566
Family:
  • Belongs to the MPP10 family.
genes like me logo Genes that share domains with MPHOSPH10: view

No data available for Gene Families for MPHOSPH10 Gene

Function for MPHOSPH10 Gene

Molecular function for MPHOSPH10 Gene

UniProtKB/Swiss-Prot Function: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing

Gene Ontology (GO) - Molecular Function for MPHOSPH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12655004
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MPHOSPH10: view

Phenotypes for MPHOSPH10 Gene

genes like me logo Genes that share phenotypes with MPHOSPH10: view

Animal Model Products

CRISPR Products

miRNA for MPHOSPH10 Gene

miRTarBase miRNAs that target MPHOSPH10

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MPHOSPH10
    • Block miRNA regulation of MPHOSPH10 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for MPHOSPH10

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MPHOSPH10 Gene

    Localization for MPHOSPH10 Gene

    Subcellular locations from UniProtKB/Swiss-Prot for MPHOSPH10 Gene

    Nucleus, nucleolus. Chromosome. Note=Fibrillar region of the nucleolus. After dissolution of the nucleolus in early M phase becomes associated with chromosomes through metaphase and anaphase. In telophase localized to small cellular prenucleolar bodies that not always contain fibrillarin. The reassociation with nucleolus is preceeded by the arrival of fibrillarin.

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for MPHOSPH10 Gene COMPARTMENTS Subcellular localization image for MPHOSPH10 gene
    Compartment Confidence
    nucleus 5
    cytosol 2
    mitochondrion 1

    Gene Ontology (GO) - Cellular Components for MPHOSPH10 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0005634 nucleus --
    GO:0005694 chromosome IEA --
    GO:0005730 nucleolus IDA --
    GO:0005732 small nucleolar ribonucleoprotein complex NAS 9450966
    GO:0030529 ribonucleoprotein complex --
    genes like me logo Genes that share ontologies with MPHOSPH10: view

    Pathways for MPHOSPH10 Gene

    genes like me logo Genes that share pathways with MPHOSPH10: view

    Pathways by source for MPHOSPH10 Gene

    1 KEGG pathway for MPHOSPH10 Gene

    Gene Ontology (GO) - Biological Process for MPHOSPH10 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0000375 RNA splicing, via transesterification reactions NAS 9450966
    GO:0006364 rRNA processing --
    GO:0006396 RNA processing NAS 9450966
    GO:0008380 RNA splicing NAS 9450966
    GO:0010923 negative regulation of phosphatase activity IDA 19389623
    genes like me logo Genes that share ontologies with MPHOSPH10: view

    Transcripts for MPHOSPH10 Gene

    Unigene Clusters for MPHOSPH10 Gene

    M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein):
    Representative Sequences:

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate MPHOSPH10
      • Block miRNA regulation of MPHOSPH10 using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for MPHOSPH10

      Primer Products

      • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MPHOSPH10

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for MPHOSPH10 Gene

      ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12
      SP1: -
      SP2:
      SP3: -
      SP4:
      SP5: -
      SP6:

      Relevant External Links for MPHOSPH10 Gene

      GeneLoc Exon Structure for
      MPHOSPH10
      ECgene alternative splicing isoforms for
      MPHOSPH10

      Expression for MPHOSPH10 Gene

      mRNA expression in normal human tissues for MPHOSPH10 Gene

      Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPHOSPH10 Gene

      SOURCE GeneReport for Unigene cluster for MPHOSPH10 Gene Hs.656208

      genes like me logo Genes that share expressions with MPHOSPH10: view

      In Situ Assay Products

      No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MPHOSPH10 Gene

      Orthologs for MPHOSPH10 Gene

      This gene was present in the common ancestor of animals and fungi.

      Orthologs for MPHOSPH10 Gene

      Organism Taxonomy Gene Similarity Type Details
      chimpanzee
      (Pan troglodytes)
      Mammalia MPHOSPH10 35
      • 99.56 (n)
      • 98.97 (a)
      MPHOSPH10 36
      • 99 (a)
      OneToOne
      cow
      (Bos Taurus)
      Mammalia MPHOSPH10 35
      • 86.07 (n)
      • 85.93 (a)
      MPHOSPH10 36
      • 85 (a)
      OneToOne
      dog
      (Canis familiaris)
      Mammalia MPHOSPH10 35
      • 87.95 (n)
      • 85.63 (a)
      MPHOSPH10 36
      • 86 (a)
      OneToOne
      mouse
      (Mus musculus)
      Mammalia Mphosph10 35
      • 83.53 (n)
      • 81.56 (a)
      Mphosph10 16
      Mphosph10 36
      • 82 (a)
      OneToOne
      oppossum
      (Monodelphis domestica)
      Mammalia MPHOSPH10 36
      • 69 (a)
      OneToOne
      platypus
      (Ornithorhynchus anatinus)
      Mammalia MPHOSPH10 36
      • 44 (a)
      OneToOne
      rat
      (Rattus norvegicus)
      Mammalia Mphosph10 35
      • 82.44 (n)
      • 79.82 (a)
      chicken
      (Gallus gallus)
      Aves MPHOSPH10 35
      • 68.15 (n)
      • 63.96 (a)
      MPHOSPH10 36
      • 61 (a)
      OneToOne
      lizard
      (Anolis carolinensis)
      Reptilia MPHOSPH10 36
      • 58 (a)
      OneToOne
      African clawed frog
      (Xenopus laevis)
      Amphibia LOC398524 35
      tropical clawed frog
      (Silurana tropicalis)
      Amphibia mphosph10 35
      • 66.02 (n)
      • 61.22 (a)
      Str.16216 35
      zebrafish
      (Danio rerio)
      Actinopterygii mphosph10 35
      • 61.78 (n)
      • 57.55 (a)
      mphosph10 36
      • 55 (a)
      OneToOne
      fruit fly
      (Drosophila melanogaster)
      Insecta CG13097 36
      • 33 (a)
      OneToOne
      CG13097 37
      • 49 (a)
      worm
      (Caenorhabditis elegans)
      Secernentea Y75B8A.7 36
      • 31 (a)
      OneToOne
      Y75B8A.7 37
      • 34 (a)
      baker's yeast
      (Saccharomyces cerevisiae)
      Saccharomycetes MPP10 36
      • 26 (a)
      OneToOne
      MPP10 38
      sea squirt
      (Ciona savignyi)
      Ascidiacea CSA.3443 36
      • 48 (a)
      OneToOne
      Species with no ortholog for MPHOSPH10:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • rainbow trout (Oncorhynchus mykiss)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • wheat (Triticum aestivum)

      Evolution for MPHOSPH10 Gene

      ENSEMBL:
      Gene Tree for MPHOSPH10 (if available)
      TreeFam:
      Gene Tree for MPHOSPH10 (if available)

      Paralogs for MPHOSPH10 Gene

      genes like me logo Genes that share paralogs with MPHOSPH10: view

      No data available for Paralogs for MPHOSPH10 Gene

      Variants for MPHOSPH10 Gene

      Sequence variations from dbSNP and Humsavar for MPHOSPH10 Gene

      SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
      rs6574 - 71,149,869(-) ACCTT(C/T)ATCCT missense, reference
      rs23907 -- 71,147,071(-) AAACT(A/C)AAACA intron-variant
      rs357742 -- 71,150,500(-) TGACA(A/T)GAGAT downstream-variant-500B
      rs357744 -- 71,147,935(-) TGAAC(A/C/G/T)GTGAA intron-variant
      rs357745 -- 71,147,663(-) CAGAG(A/C)CTTGC intron-variant

      Structural Variations from Database of Genomic Variants (DGV) for MPHOSPH10 Gene

      Variant ID Type Subtype PubMed ID
      nsv874253 CNV Gain 21882294
      nsv834256 CNV Gain 17160897
      esv2720185 CNV Deletion 23290073
      esv2662403 CNV Deletion 23128226
      nsv874254 CNV Loss 21882294
      nsv2771 CNV Loss 18451855
      dgv1196e1 CNV Complex 17122850
      nsv508148 CNV Loss 20534489

      Relevant External Links for MPHOSPH10 Gene

      HapMap Linkage Disequilibrium report
      MPHOSPH10

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPHOSPH10 Gene

      Disorders for MPHOSPH10 Gene

      Relevant External Links for MPHOSPH10

      Genetic Association Database (GAD)
      MPHOSPH10
      genes like me logo Genes that share disorders with MPHOSPH10: view

      No data available for UniProtKB/Swiss-Prot for MPHOSPH10 Gene

      Publications for MPHOSPH10 Gene

      1. M phase phosphoprotein 10 is a human U3 small nucleolar ribonucleoprotein component. (PMID: 9450966) Westendorf J.M. … Baserga S.J. (Mol. Biol. Cell 1998) 2 3 4 23
      2. Identification of novel M phase phosphoproteins by expression cloning. (PMID: 8885239) Matsumoto-Taniura N. … Westendorf J.M. (Mol. Biol. Cell 1996) 2 3 4
      3. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
      4. The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. (PMID: 12655004) Granneman S. … Pruijn G.J.M. (Nucleic Acids Res. 2003) 3 4
      5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

      Products for MPHOSPH10 Gene

      Sources for MPHOSPH10 Gene

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