Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MPHOSPH10 Gene

Aliases for MPHOSPH10 Gene

  • M-Phase Phosphoprotein 10 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 106 2 3
  • U3 Small Nucleolar Ribonucleoprotein 2 3
  • M Phase Phosphoprotein 10 3 4
  • MPP10 3 4
  • M-Phase Phosphoprotein 10 (U3 Small Nucleolar Ribonucleoprotein) 2
  • U3 Small Nucleolar Ribonucleoprotein Protein MPP10 3
  • PPP1R106 3
  • MPP10P 3
  • CT90 3

External Ids for MPHOSPH10 Gene

Previous GeneCards Identifiers for MPHOSPH10 Gene

  • GC02P071366
  • GC02P071569
  • GC02P071331
  • GC02P071269
  • GC02P071210
  • GC02P071358
  • GC02P071094

Summaries for MPHOSPH10 Gene

Entrez Gene Summary for MPHOSPH10 Gene

  • This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing. [provided by RefSeq, Dec 2010]

GeneCards Summary for MPHOSPH10 Gene

MPHOSPH10 (M-Phase Phosphoprotein 10) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for MPHOSPH10 Gene

  • Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

Gene Wiki entry for MPHOSPH10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPHOSPH10 Gene

Genomics for MPHOSPH10 Gene

Regulatory Elements for MPHOSPH10 Gene

Enhancers for MPHOSPH10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G071128 1.4 ENCODE dbSUPER 17.2 +0.4 391 4.4 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 ZNF610 MPHOSPH10 TEX261 NAGK ANKRD53 MCEE LOC101060051
GH02G071226 1.1 ENCODE 20.7 +96.7 96668 1.8 HDGF PKNOX1 FOXA2 SIN3A FEZF1 ZNF2 ZBTB7B YY1 ZNF143 FOS MPHOSPH10 TEX261 ANKRD53 PAIP2B ENSG00000233870
GH02G071062 1.7 Ensembl ENCODE dbSUPER 11.2 -61.7 -61710 11.8 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC NAGK MPHOSPH10 OR7E62P ENSG00000272735 GC02P071073
GH02G071000 1.6 FANTOM5 Ensembl ENCODE 11.2 -128.5 -128505 2.0 HDGF MLX WRNIP1 ARID4B DMAP1 ZNF2 ZNF48 GLIS2 CBX5 ELK1 TEX261 MPHOSPH10 ANKRD53 NAGK ENSG00000258881 OR7E91P
GH02G071617 0.8 dbSUPER 20.3 +488.9 488880 2.4 CTCF ZSCAN4 ZNF133 MAX GLI4 CDC5L RAD21 HIC1 ZFHX2 ZNF791 MPHOSPH10 CLEC4F TEX261 GC02P071578 GC02P071827
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MPHOSPH10 on UCSC Golden Path with GeneCards custom track

Promoters for MPHOSPH10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000118756 -114 2801 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC MEF2D SSRP1

Genomic Location for MPHOSPH10 Gene

71,130,314 bp from pter
71,150,102 bp from pter
19,789 bases
Plus strand

Genomic View for MPHOSPH10 Gene

Genes around MPHOSPH10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPHOSPH10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPHOSPH10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPHOSPH10 Gene

Proteins for MPHOSPH10 Gene

  • Protein details for MPHOSPH10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U3 small nucleolar ribonucleoprotein protein MPP10
    Protein Accession:
    Secondary Accessions:
    • A0AVJ8

    Protein attributes for MPHOSPH10 Gene

    681 amino acids
    Molecular mass:
    78864 Da
    Quaternary structure:
    • Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with IMP3 and IMP4.

neXtProt entry for MPHOSPH10 Gene

Post-translational modifications for MPHOSPH10 Gene

Other Protein References for MPHOSPH10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MPHOSPH10 Gene

Domains & Families for MPHOSPH10 Gene

Gene Families for MPHOSPH10 Gene

Protein Domains for MPHOSPH10 Gene


Suggested Antigen Peptide Sequences for MPHOSPH10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MPP10 family.
  • Belongs to the MPP10 family.
genes like me logo Genes that share domains with MPHOSPH10: view

Function for MPHOSPH10 Gene

Molecular function for MPHOSPH10 Gene

UniProtKB/Swiss-Prot Function:
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

Gene Ontology (GO) - Molecular Function for MPHOSPH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 12655004
genes like me logo Genes that share ontologies with MPHOSPH10: view
genes like me logo Genes that share phenotypes with MPHOSPH10: view

Animal Model Products

CRISPR Products

miRNA for MPHOSPH10 Gene

miRTarBase miRNAs that target MPHOSPH10

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPHOSPH10 Gene

Localization for MPHOSPH10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPHOSPH10 Gene

Nucleus, nucleolus. Chromosome. Note=Fibrillar region of the nucleolus (PubMed:9450966). After dissolution of the nucleolus in early M phase becomes associated with chromosomes through metaphase and anaphase (PubMed:9450966). In telophase localized to small cellular prenucleolar bodies that not always contain fibrillarin (PubMed:9450966). The reassociation with nucleolus is preceeded by the arrival of fibrillarin (PubMed:9450966). {ECO:0000269 PubMed:9450966}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPHOSPH10 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MPHOSPH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA 9450966
GO:0005732 small nucleolar ribonucleoprotein complex NAS,IEA 9450966
genes like me logo Genes that share ontologies with MPHOSPH10: view

Pathways & Interactions for MPHOSPH10 Gene

genes like me logo Genes that share pathways with MPHOSPH10: view

Gene Ontology (GO) - Biological Process for MPHOSPH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000375 RNA splicing, via transesterification reactions NAS 9450966
GO:0006364 rRNA processing IEA,TAS --
GO:0006396 RNA processing NAS 9450966
GO:0008380 RNA splicing NAS 9450966
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with MPHOSPH10: view

No data available for SIGNOR curated interactions for MPHOSPH10 Gene

Drugs & Compounds for MPHOSPH10 Gene

No Compound Related Data Available

Transcripts for MPHOSPH10 Gene

Unigene Clusters for MPHOSPH10 Gene

M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPHOSPH10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12
SP1: -
SP3: -
SP5: -

Relevant External Links for MPHOSPH10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPHOSPH10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MPHOSPH10 Gene

Protein differential expression in normal tissues from HIPED for MPHOSPH10 Gene

This gene is overexpressed in Heart (10.5), Peripheral blood mononuclear cells (10.4), Blymphocyte (8.5), Lung (7.4), and CD8 Tcells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MPHOSPH10 Gene

Protein tissue co-expression partners for MPHOSPH10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MPHOSPH10 Gene:


SOURCE GeneReport for Unigene cluster for MPHOSPH10 Gene:


Evidence on tissue expression from TISSUES for MPHOSPH10 Gene

  • Liver(4.3)
  • Nervous system(4.3)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with MPHOSPH10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPHOSPH10 Gene

Orthologs for MPHOSPH10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MPHOSPH10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MPHOSPH10 34 35
  • 99.56 (n)
(Canis familiaris)
Mammalia MPHOSPH10 34 35
  • 87.95 (n)
(Bos Taurus)
Mammalia MPHOSPH10 34 35
  • 86.07 (n)
(Mus musculus)
Mammalia Mphosph10 34 16 35
  • 83.53 (n)
(Rattus norvegicus)
Mammalia Mphosph10 34
  • 82.44 (n)
(Monodelphis domestica)
Mammalia MPHOSPH10 35
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia MPHOSPH10 35
  • 44 (a)
(Gallus gallus)
Aves MPHOSPH10 34 35
  • 68.15 (n)
(Anolis carolinensis)
Reptilia MPHOSPH10 35
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mphosph10 34
  • 66.02 (n)
Str.16216 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398524 34
(Danio rerio)
Actinopterygii mphosph10 34 35
  • 61.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13097 36 35
  • 49 (a)
(Caenorhabditis elegans)
Secernentea Y75B8A.7 36 35
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MPP10 35 37
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3443 35
  • 48 (a)
Species where no ortholog for MPHOSPH10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPHOSPH10 Gene

Gene Tree for MPHOSPH10 (if available)
Gene Tree for MPHOSPH10 (if available)

Paralogs for MPHOSPH10 Gene

No data available for Paralogs for MPHOSPH10 Gene

Variants for MPHOSPH10 Gene

Sequence variations from dbSNP and Humsavar for MPHOSPH10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs201494468 Uncertain significance 71,130,255(+) GCCAC(A/C/G)GAGGT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000154373 -- 71,143,449(+) GGCCA(-/T)TTTTT intron-variant
rs1000367572 -- 71,137,330(+) GACGC(A/T)TAGGC intron-variant
rs1000382450 -- 71,136,841(+) AGAAC(G/T)TTCAA intron-variant
rs1000408593 -- 71,150,340(+) AGGCT(A/G)TGAAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MPHOSPH10 Gene

Variant ID Type Subtype PubMed ID
esv2662403 CNV deletion 23128226
esv2720185 CNV deletion 23290073
esv2759059 CNV loss 17122850
nsv1009014 CNV gain 25217958
nsv1146915 OTHER inversion 26484159
nsv2771 CNV deletion 18451855
nsv508148 CNV deletion 20534489
nsv834256 CNV gain 17160897
nsv963616 CNV duplication 23825009

Variation tolerance for MPHOSPH10 Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.66; 99.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPHOSPH10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPHOSPH10 Gene

Disorders for MPHOSPH10 Gene

Relevant External Links for MPHOSPH10

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MPHOSPH10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPHOSPH10 Gene

Publications for MPHOSPH10 Gene

  1. M phase phosphoprotein 10 is a human U3 small nucleolar ribonucleoprotein component. (PMID: 9450966) Westendorf J.M. … Baserga S.J. (Mol. Biol. Cell 1998) 2 3 4 22 64
  2. Identification of novel M phase phosphoproteins by expression cloning. (PMID: 8885239) Matsumoto-Taniura N. … Westendorf J.M. (Mol. Biol. Cell 1996) 2 3 4 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. (PMID: 12655004) Granneman S. … Pruijn G.J.M. (Nucleic Acids Res. 2003) 3 4 64

Products for MPHOSPH10 Gene

Sources for MPHOSPH10 Gene

Loading form....