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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MPG Gene

protein-coding   GIFtS: 63
GCID: GC16P000127

N-Methylpurine-DNA Glycosylase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
N-Methylpurine-DNA Glycosylase1 2 3     PIG112
3-Alkyladenine DNA Glycosylase2 3     PIG162
3-Methyladenine DNA Glycosidase2 3     anpg2
AAG2 3     CRA36.1 (3-Methyl-Adenine DNA Glycosylase)2
ADPG2 3     DNA-3-Methyladenine Glycosylase2
MDG2 5     N-Methylpurine-DNA Glycosylase, MPG2
Alkyladenine DNA Glycosylase1     Proliferation-Inducing Protein 112
3' End Of The Mid1 Gene, Localized 68 Kb Upstream The Humanzeta Globin
Gene On 16p2
     Proliferation-Inducing Protein 162
APNG2     ANPG3
CRA36.12     EC 3.2.2.213
Mid12     MID13

External Ids:    HGNC: 72111   Entrez Gene: 43502   Ensembl: ENSG000001031527   OMIM: 1565655   UniProtKB: P293723   

Export aliases for MPG gene to outside databases

Previous GC identifers: GC16P000148 GC16P000067 GC16P000069 GC16P000068 GC16P000046


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MPG Gene: 
MPG (N-methylpurine-DNA glycosylase) is a protein-coding gene. Diseases associated with MPG include lutembacher's syndrome, and tricuspid valve stenosis, and among its related super-pathways are Removal of DNA patch containing abasic residue and Base-free sugar-phosphate removal via the single-nucleotide replacement pathway. GO annotations related to this gene include damaged DNA binding and DNA-7-methylguanine glycosylase activity.

UniProtKB/Swiss-Prot: 3MG_HUMAN, P29372
Function: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the
damaged DNA polymer formed by alkylation lesions

Gene Wiki entry for MPG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MPG gene promoter:
         STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMPG promoter sequence
   Search SABiosciences Chromatin IP Primers for MPG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

MPG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPG gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P000127:  view genomic region     (about GC identifiers)

Start:
127,006 bp from pter      End:
135,852 bp from pter
Size:
8,847 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 3MG_HUMAN, P29372 (See protein sequence)
Recommended Name: DNA-3-methyladenine glycosylase  
Size: 298 amino acids; 32869 Da
Subunit: Binds MBD1
Subcellular location: Nucleus (Potential)
6 PDB 3D structures from and Proteopedia for MPG:
1BNK (3D)        1EWN (3D)        1F4R (3D)        1F6O (3D)        3QI5 (3D)        3UBY (3D)    
Secondary accessions: G5E9E2 Q13770 Q15275 Q15961 Q5J9I4 Q96BZ6 Q96S33 Q9NNX5
Alternative splicing: 4 isoforms:  P29372-1   P29372-2   P29372-4   P29372-5   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for MPG: NX_P29372

Explore proteomics data for MPG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P29372

  • MPG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MPG Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001015052.1  NP_001015054.1  NP_002425.2  

    ENSEMBL proteins: 
     ENSP00000388097   ENSP00000348809   ENSP00000219431   ENSP00000380918  
    Reactome Protein details: P29372
    Human Recombinant Protein Products for MPG: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals MPG Proteins
    Novus Biologicals MPG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MPG
    Cloud-Clone Corp. Proteins for MPG 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--

    MPG for ontologies           About GeneDecksing



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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MPG 
    Cloud-Clone Corp. CLIAs for MPG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR011034 Formyl_transferase_C-like
     IPR003180 PurDNA_glycsylse

    Graphical View of Domain Structure for InterPro Entry P29372

    ProtoNet protein and cluster: P29372

    1 Blocks protein domain: IPB003180 Methylpurine-DNA glycosylase (MPG)

    UniProtKB/Swiss-Prot: 3MG_HUMAN, P29372
    Similarity: Belongs to the DNA glycosylase MPG family


    MPG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 3MG_HUMAN, P29372
    Function: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the
    damaged DNA polymer formed by alkylation lesions
    Catalytic activity: Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and
    7-methyladenine

         Genatlas biochemistry entry for MPG:
    DNA glycosylase,3-methyl-adenine,base excision repair

         Enzyme Number (IUBMB): EC 3.2.2.211

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003684damaged DNA binding TAS10854423
    GO:0003824catalytic activity ----
    GO:0003905alkylbase DNA N-glycosylase activity ----
    GO:0005515protein binding IPI18482256
         
    MPG for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MPG:
     Decreased G3BP1 protein expres  Decreased circadian period len  Decreased influenza A virus in 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mpg):
     adipose tissue  cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  tumorigenesis 

    MPG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MPG: Mpgtm1Rhe Mpgtm1Lds

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MPG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MPG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MPG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MPG 

    miRNA
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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of MPG 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MPG About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Resolution of Abasic Sites (AP sites)
    Resolution of Abasic Sites (AP sites)0.89
    Removal of DNA patch containing abasic residue0.89
    Resolution of AP sites via the multiple-nucleotide patch replacement pathway0.89
    Base excision repair0.53
    Base Excision Repair0.89
    2Base-Excision Repair, AP Site Formation
    Base-free sugar-phosphate removal via the single-nucleotide replacement pathway0.90
    Depurination0.38
    Displacement of DNA glycosylase by APE10.90
    Recognition and association of DNA glycosylase with site containing an affected purine0.38
    Base-Excision Repair, AP Site Formation0.89
    Cleavage of the damaged purine0.38
    Resolution of AP sites via the single-nucleotide replacement pathway0.83
    3Nucleotide Excision Repair
    DNA Repair0.46
    4Busulfan Pathway, Pharmacodynamics
    Busulfan Pathway, Pharmacodynamics

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/12        Reactome Pathways for MPG (see all 12)
        Removal of DNA patch containing abasic residue
    DNA Repair
    Resolution of AP sites via the multiple-nucleotide patch replacement pathway
    Base-Excision Repair, AP Site Formation
    Base Excision Repair

    1 PharmGKB Pathway for MPG
        Busulfan Pathway, Pharmacodynamics

    1         Kegg Pathway  (Kegg details for MPG):
        Base excision repair


    MPG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MPG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/45 Interacting proteins for MPG (P293721, 2, 3 ENSP000002194314) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRNPP041561, 3EBI-1043398,EBI-977302 I2D: score=1 
    XRCC1P188872, 3, ENSP000002628874MINT-7294862 I2D: score=1 STRING: ENSP00000262887
    RAD23AP547253, ENSP000003213654I2D: score=2 STRING: ENSP00000321365
    CAPZA1P529073, ENSP000002631684I2D: score=1 STRING: ENSP00000263168
    MIFP141743, ENSP000002157544I2D: score=1 STRING: ENSP00000215754
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS--
    GO:0006284base-excision repair TAS--
    GO:0006285base-excision repair, AP site formation TAS--
    GO:0006307DNA dealkylation involved in DNA repair TAS1645538
    GO:0045007depurination TAS--

    MPG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MPG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MPG (3MG)

    5 HMDB Compounds for MPG    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Methyladenine3-methyl-3H-Purin-6-amine (see all 5)5142-23-4--
    3-MethylguanineN3-Methylguanine (see all 5)2958-98-7--
    7-Methyladenine7-Methyl-7H-purin-6-amine (see all 6)935-69-3--
    7-Methylguanine2-Amino-6-hydroxy-7-methylpurine (see all 8)578-76-7--
    LoperamideApo-Loperamide (see all 10)53179-11-6--

    10/35 Novoseek inferred chemical compound relationships for MPG gene (see all 35)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1,n6-ethenoadenine 97.4 29 1409645 (2), 10891085 (2), 12202763 (1), 10626225 (1) (see all 18)
    3-methyladenine 96.5 99 9895121 (5), 8475094 (4), 15651853 (4), 8435858 (4) (see all 44)
    3-methylguanine 94.5 7 1874728 (1), 14729667 (1), 7528899 (1), 8435858 (1) (see all 5)
    7-methylguanine 93.2 19 9813117 (2), 15651853 (2), 1874728 (1), 19219989 (1) (see all 11)
    apng 92.3 13 12202763 (4), 16290249 (3), 10626224 (2), 9837917 (2) (see all 5)
    hypoxanthine 83 69 17716976 (5), 19219989 (3), 17655363 (3), 19449863 (2) (see all 21)
    3,n(4)-ethenocytosine 77.8 1 14761949 (1)
    o6-methylguanine 74.9 3 11410664 (1), 18992265 (1), 9103402 (1)
    chloroethyl nitrosoureas 74.4 2 7605343 (1), 12663522 (1)
    methylmethanesulfonate 74.1 12 1874728 (2), 18992265 (2), 12566303 (2), 16288039 (2) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about MPG / 3MG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MPG gene (3 alternative transcripts): 
    NM_001015052.2  NM_001015054.2  NM_002434.3  

    Unigene Cluster for MPG:

    N-methylpurine-DNA glycosylase
    Hs.459596  [show with all ESTs]
    Unigene Representative Sequence: BF572325
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436333 ENST00000356432(uc010bqp.3 uc002cfo.3) ENST00000475280
    ENST00000219431(uc002cfn.3) ENST00000397817(uc002cfm.3)
    miRNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPG
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPG
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    Additional mRNA sequence: 

    AK308654.1 AY258284.1 BC014991.1 L10752.1 M71215.1 M74905.1 M99626.1 S51033.1 
    X56528.1 

    14 DOTS entries:

    DT.100042094  DT.444615  DT.100782934  DT.92446754  DT.95292872  DT.120688508  DT.95092525  DT.120688515 
    DT.100782930  DT.100782931  DT.101956434  DT.121645427  DT.95226846  DT.95246148 

    24/263 AceView cDNA sequences (see all 263):

    BM720878 BU168113 CB044049 AI565950 AA299077 AW593038 CD105357 AW050694 
    F04542 CR598824 CR619346 BX281276 BU631253 AW024618 BM852297 BQ684616 
    BQ053339 BM771938 N91934 AI521404 BI253826 AI131317 BE221981 AI423285 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MPG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGGGAGTG
    MPG Expression
    About this image


    See MPG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MPG

    SOURCE GeneReport for Unigene cluster: Hs.459596
        SABiosciences Expression via Pathway-Focused PCR Arrays including MPG: 
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MPG gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mpg1 , 5 N-methylpurine-DNA glycosylase1, 5 80.38(n)1
    82.31(a)1
      11 (18.83 cM)5
    2683951  NM_010822.31  NP_034952.21 
     322265055 
    chicken
    (Gallus gallus)
    Aves MPG1 N-methylpurine-DNA glycosylase 63.76(n)
    60.17(a)
      416648  XM_414945.3  XP_414945.3 
    lizard
    (Anolis carolinensis)
    Reptilia MPG6
    Uncharacterized protein
    56(a)
    1 ↔ 1
    AAWZ02037681(14519-15066)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.161682 Xenopus laevis transcribed sequence with weak similarity more 71.09(n)    BJ045678.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mpg1 N-methylpurine-DNA glycosylase 59.11(n)
    59.11(a)
      566516  NM_001082850.1  NP_001076319.1 


    ENSEMBL Gene Tree for MPG (if available)
    TreeFam Gene Tree for MPG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/403 SNPs in MPG are shown (see all 403)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
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    ----------
    VAR_0148364
    ----see VAR_0148362 A S mis40--------
    VAR_0148354
    ----see VAR_0148352 A V mis40--------
    rs1163364051,2
    C,F--125019(+) GGACGC/TGCACG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1484462031,2
    --125024(+) CGCACA/GAAACT 1 -- us2k10--------
    rs1848897301,2
    --125053(+) ACATAA/GACAAG 1 -- us2k10--------
    rs1898206641,2
    --125054(+) CATAGA/CCAAGT 1 -- us2k10--------
    rs753076411,2
    F--125128(+) CCCCTA/GTACGG 1 -- us2k11Minor allele frequency- G:0.08WA 118
    rs25621571,2
    C,F--125181(+) GGAGAA/GATGGA 1 -- us2k1 tfbs31Minor allele frequency- G:0.04WA 118
    rs801732071,2
    C,F--125231(+) CAGGCG/ATCTGA 1 -- us2k13Minor allele frequency- A:0.06WA NA EA 358
    rs1150072131,2
    C,F--125285(+) GCCCTC/TACACC 1 -- us2k13Minor allele frequency- T:0.07WA NA EA 358

    HapMap Linkage Disequilibrium report for MPG (127006 - 135852 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for MPG (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1240373CNV Deletion17803354
    nsv820705CNV Duplication20802225
    esv2422427CNV Duplication17116639
    esv996836CNV Insertion20482838
    esv1393228CNV Insertion17803354
    nsv904628CNV Loss21882294
    nsv904631CNV Loss21882294
    nsv904634CNV Loss21882294
    esv32706CNV Loss17666407
    dgv2456n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): MPG
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MPG
    DNA2.0 Custom Variant and Variant Library Synthesis for MPG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 156565    OMIM disorders: --

    20/23 diseases for MPG (see all 23):    About MalaCards
    lutembacher's syndrome    tricuspid valve stenosis    familial colorectal cancer    hepatitis a
    graft versus host disease    chronic lymphocytic leukemia    meningioma    colorectal cancer
    osteosarcoma    ovarian cancer    malignant glioma    multiple sclerosis
    tuberculosis    lung cancer    rheumatoid arthritis    breast cancer
    arthritis    glioblastoma    cervicitis    melanoma


    MPG for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for MPG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chromosomal aberrations 20.6 3 7528899 (2), 9731510 (1)
    cancer lung 5.59 3 10477488 (2)
    inflammation 0 1 14679184 (1)
    glioma 0 1 17255284 (1)
    breast cancer 0 14 9684856 (2), 15299078 (2), 10563836 (2), 12566303 (2) (see all 5)
    ovarian cancer 0 2 17200364 (1)
    nsclc 0 5 16613673 (2), 10477488 (1)
    tumors 0 38 12820404 (8), 11724299 (4), 12014652 (4), 16288039 (2) (see all 10)
    carcinoma 0 5 11724299 (2), 12014652 (1), 16288039 (1)
    cancer 0 6 16834910 (1), 15299078 (1), 8611396 (1)

    Genetic Association Database (GAD): MPG
    Human Genome Epidemiology (HuGE) Navigator: MPG (16 documents)

    Export disorders for MPG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MPG gene, integrated from 9 sources (see all 172):
    (articles sorted by number of sources associating them with MPG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase. (PubMed id 1874728)1, 2, 3, 9 Chakravarti D.... Mitra S. (1991)
    2. Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin. (PubMed id 14555760)1, 2, 9 Watanabe S.... Nakao M. (2003)
    3. Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere. (PubMed id 8475094)1, 2, 9 Vickers M.A.... Higgs D.R. (1993)
    4. Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse. (PubMed id 8318735)1, 2, 9 Kielman M.... Bernini L.F. (1993)
    5. Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision. (PubMed id 9790531)1, 2, 9 Lau A.Y.... Ellenberger T. (1998)
    6. Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16. (PubMed id 1924375)1, 2, 9 Samson L.... Call K. (1991)
    7. Genetic polymorphisms of the DNA repair gene MPG may be associated with susceptibility to rheumatoid arthritis. (PubMed id 21063071)1, 4 Chen S.Y....Tsai F.J. (2010)
    8. Polymorphisms in the base excision repair pathway and graft-versus-host disease. (PubMed id 20574454)1, 4 Arora M....Thyagarajan B. (2010)
    9. Variation within DNA repair pathway genes and risk of multiple sclerosis. (PubMed id 20522537)1, 4 Briggs F.B....Barcellos L.F. (2010)
    10. Association between genetic variants in the base exci sion repair pathway and outcomes after hematopoietic cell transplantations. (PubMed id 20226869)1, 4 Thyagarajan B....Arora M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4350 HGNC: 7211 AceView: MPG Ensembl:ENSG00000103152 euGenes: HUgn4350
    ECgene: MPG Kegg: 4350 H-InvDB: MPG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MPG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MPG Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mpg/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MPG gene:
    Search GeneIP for patents involving MPG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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