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Aliases for MPG Gene

Aliases for MPG Gene

  • N-Methylpurine DNA Glycosylase 2 3 5
  • 3-Methyladenine DNA Glycosidase 3 4
  • 3-Alkyladenine DNA Glycosylase 3 4
  • Mid1 3 4
  • Anpg 3 4
  • ADPG 3 4
  • AAG 3 4
  • 3 End Of The Mid1 Gene, Localized 68 Kb Upstream The Humanzeta Globin Gene On 16p 3
  • CRA36.1 (3-Methyl-Adenine DNA Glycosylase) 3
  • N-Methylpurine-DNA Glycosylase, MPG 3
  • Proliferation-Inducing Protein 11 3
  • Proliferation-Inducing Protein 16 3
  • DNA-3-Methyladenine Glycosylase 3
  • N-Methylpurine-DNA Glycosylase 4
  • Alkyladenine DNA Glycosylase 2
  • EC 4
  • CRA36.1 3
  • PIG11 3
  • PIG16 3
  • APNG 3
  • MDG 3

External Ids for MPG Gene

Previous GeneCards Identifiers for MPG Gene

  • GC16P000148
  • GC16P000067
  • GC16P000069
  • GC16P000068
  • GC16P000127
  • GC16P000046
  • GC16P000087
  • GC16P000097
  • GC16P000108
  • GC16P000116

Summaries for MPG Gene

GeneCards Summary for MPG Gene

MPG (N-Methylpurine DNA Glycosylase) is a Protein Coding gene. Among its related pathways are Recognition and association of DNA glycosylase with site containing an affected purine and Telomere C-strand (Lagging Strand) Synthesis. GO annotations related to this gene include damaged DNA binding and DNA-3-methyladenine glycosylase activity.

UniProtKB/Swiss-Prot for MPG Gene

  • Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

Gene Wiki entry for MPG Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPG Gene

Genomics for MPG Gene

Regulatory Elements for MPG Gene

Enhancers for MPG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F000981 0.6 ENCODE 12.9 +904.5 904469 0.2 ZNF493 ZNF133 GLI4 ZNF2 GLIS2 ZNF416 KLF7 ZNF548 MCM3 SP3 HN1L JMJD8 ENSG00000261505 ENSG00000260954 ENSG00000255513 ENSG00000260646 SNORA64 RHOT2 ENSG00000226890 PRSS29P
GH16F000104 1.2 FANTOM5 ENCODE 12.2 +27.8 27776 1.0 HDGF ATF1 GLI4 ZNF2 YY1 GLIS2 GATA2 SP3 SMARCA4 GLIS1 HBM ENSG00000228779 NPRL3 HBZ MPG RHBDF1 HBQ1 SNRNP25 NHLRC4 GC16P000121
GH16F000106 0.7 ENCODE 12.2 +30.3 30267 1.0 HDGF ELF3 CBX3 INSM2 ARID4B ZNF2 RAD21 SCRT2 ZNF143 ZNF391 HBZ HBM MPG RHBDF1 SNRNP25 GC16P000121 GC16P000117
GH16F000083 0.6 Ensembl ENCODE 11.4 +8.1 8144 2.9 HDGF TBP PKNOX1 INSM2 KLF17 BMI1 NFXL1 ZBTB40 ZNF121 EGR1 MPG SNRNP25 GC16M000080 PIR62648
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MPG on UCSC Golden Path with GeneCards custom track

Promoters for MPG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000501926 1293 1401 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 GLIS2 KDM4B

Genomic Location for MPG Gene

77,007 bp from pter
85,853 bp from pter
8,847 bases
Plus strand

Genomic View for MPG Gene

Genes around MPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPG Gene

Proteins for MPG Gene

  • Protein details for MPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DNA-3-methyladenine glycosylase
    Protein Accession:
    Secondary Accessions:
    • G5E9E2
    • Q13770
    • Q15275
    • Q15961
    • Q5J9I4
    • Q96BZ6
    • Q96S33
    • Q9NNX5

    Protein attributes for MPG Gene

    298 amino acids
    Molecular mass:
    32869 Da
    Quaternary structure:
    • Binds MBD1. Binds SSBP1.

    Three dimensional structures from OCA and Proteopedia for MPG Gene

    Alternative splice isoforms for MPG Gene


neXtProt entry for MPG Gene

Post-translational modifications for MPG Gene

  • Ubiquitination at Lys 80 and Lys 229
  • Modification sites at PhosphoSitePlus

Other Protein References for MPG Gene

Antibody Products

No data available for DME Specific Peptides for MPG Gene

Domains & Families for MPG Gene

Gene Families for MPG Gene

Protein Domains for MPG Gene

Suggested Antigen Peptide Sequences for MPG Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DNA glycosylase MPG family.
  • Belongs to the DNA glycosylase MPG family.
genes like me logo Genes that share domains with MPG: view

Function for MPG Gene

Molecular function for MPG Gene

GENATLAS Biochemistry:
DNA glycosylase,3-methyl-adenine,base excision repair
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Binding to SSBP1 in mitochondria inhibits glycosylase activity in the context of a single-stranded DNA (ssDNA), but not a double-stranded DNA (dsDNA) substrates.
UniProtKB/Swiss-Prot Function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

Enzyme Numbers (IUBMB) for MPG Gene

Gene Ontology (GO) - Molecular Function for MPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003684 damaged DNA binding TAS 10854423
GO:0003824 catalytic activity IEA --
GO:0003905 alkylbase DNA N-glycosylase activity IBA --
GO:0005515 protein binding IPI 18482256
GO:0008725 DNA-3-methyladenine glycosylase activity IEA --
genes like me logo Genes that share ontologies with MPG: view
genes like me logo Genes that share phenotypes with MPG: view

Animal Models for MPG Gene

MGI Knock Outs for MPG:

Animal Model Products

miRNA for MPG Gene

miRTarBase miRNAs that target MPG

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MPG Gene

Localization for MPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPG Gene

Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid. Nucleus.

Subcellular locations from

Jensen Localization Image for MPG Gene COMPARTMENTS Subcellular localization image for MPG gene
Compartment Confidence
nucleus 5
mitochondrion 4
chloroplast 2
cytoskeleton 2
cytosol 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MPG: view

Pathways & Interactions for MPG Gene

genes like me logo Genes that share pathways with MPG: view

Pathways by source for MPG Gene

Gene Ontology (GO) - Biological Process for MPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006284 base-excision repair TAS 10854423
GO:0006307 DNA dealkylation involved in DNA repair TAS 1645538
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0045007 depurination TAS --
genes like me logo Genes that share ontologies with MPG: view

No data available for SIGNOR curated interactions for MPG Gene

Drugs & Compounds for MPG Gene

(16) Drugs for MPG Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Loperamide Approved Pharma 143
3-Methyladenine Experimental Pharma Class III PI3K inhibitor, Class III PI 3-kinase inhibitor; also inhibits autophagy 0

(21) Additional Compounds for MPG Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 3-Methyl-Guanine (VAN) (8CI)
  • 3-Methylguanine
  • 7-Dihydro-3-methyl-2-amino-3-6H-Purin-6-one
  • 7-Dihydro-3-methyl-2-amino-3-6H-Purin-6-one (9CI)
  • N3-Methylguanine
  • 2-Amino-1,7-dihydroxy-7-methyl-6H-purine-6-one
  • 2-Amino-6-hydroxy-7-methylpurine
  • 2-Amino-7-methylhypoxanthine
  • 7-Methyl-Guanine
  • 7-Methyl-Guanine (8CI)
  • 6-Amino-7-methylpurine
  • 7-Methyl-7H-purin-6-amine
  • 7-Methyl-7H-purin-6-amine (ACD/Name 4.0)
  • 7-Methyl-7H-purin-6-ylamine (ACD/Name 4.0)
  • 7-Methyl-N7-Methyladenine
genes like me logo Genes that share compounds with MPG: view

Transcripts for MPG Gene

Unigene Clusters for MPG Gene

N-methylpurine-DNA glycosylase:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPG Gene

No ASD Table

Relevant External Links for MPG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPG Gene

mRNA expression in normal human tissues for MPG Gene

Protein differential expression in normal tissues from HIPED for MPG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.3), Blymphocyte (7.0), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MPG Gene

Protein tissue co-expression partners for MPG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MPG Gene:


SOURCE GeneReport for Unigene cluster for MPG Gene:

genes like me logo Genes that share expression patterns with MPG: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MPG Gene

Orthologs for MPG Gene

This gene was present in the common ancestor of chordates.

Orthologs for MPG Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia MPG 34 35
  • 82.73 (n)
(Pan troglodytes)
Mammalia MPG 35
  • 82 (a)
(Bos Taurus)
Mammalia MPG 34 35
  • 80.75 (n)
(Mus musculus)
Mammalia Mpg 34 16 35
  • 79.36 (n)
(Rattus norvegicus)
Mammalia Mpg 34
  • 77.08 (n)
(Monodelphis domestica)
Mammalia MPG 35
  • 65 (a)
(Gallus gallus)
Aves MPG 34 35
  • 63.76 (n)
(Anolis carolinensis)
Reptilia MPG 35
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC549932 34
  • 58.52 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16168 34
(Danio rerio)
Actinopterygii mpg 34 35
  • 59.76 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
Species where no ortholog for MPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPG Gene

Gene Tree for MPG (if available)
Gene Tree for MPG (if available)

Paralogs for MPG Gene

No data available for Paralogs for MPG Gene

Variants for MPG Gene

Sequence variations from dbSNP and Humsavar for MPG Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1013358 -- 78,955(+) GCTCA(C/T)CCCTC intron-variant
rs1050764 -- 85,522(+) GAGCT(C/T)TGCAG downstream-variant-500B, reference, synonymous-codon
rs1061435 -- 84,442(-) GCCTG(G/T)AGGTG intron-variant
rs1061438 -- 84,458(-) GGGAG(C/T)CCGAA intron-variant
rs111253415 -- 82,085(+) CCCAC(A/G)CTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPG Gene

Variant ID Type Subtype PubMed ID
dgv2688n100 CNV gain 25217958
dgv2689n100 CNV gain 25217958
dgv2690n100 CNV gain 25217958
esv1240373 CNV deletion 17803354
esv1393228 CNV insertion 17803354
esv2422427 CNV duplication 17116639
esv26636 CNV gain+loss 19812545
esv2760065 CNV gain 17122850
esv32706 CNV loss 17666407
esv3637536 CNV loss 21293372
esv3637537 CNV gain 21293372
esv996836 CNV insertion 20482838
nsv1044142 CNV gain 25217958
nsv1045829 CNV gain 25217958
nsv518291 CNV loss 19592680
nsv570924 CNV loss 21841781
nsv820705 CNV duplication 20802225
nsv9317 CNV gain 18304495

Variation tolerance for MPG Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPG Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPG Gene

Disorders for MPG Gene

Relevant External Links for MPG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPG Gene

Publications for MPG Gene

  1. Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase. (PMID: 1874728) Chakravarti D. … Mitra S. (J. Biol. Chem. 1991) 2 3 4 22 64
  2. Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin. (PMID: 14555760) Watanabe S. … Nakao M. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 22 64
  3. Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision. (PMID: 9790531) Lau A.Y. … Ellenberger T. (Cell 1998) 3 4 22 64
  4. Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse. (PMID: 8318735) Kielman M.F. … Bernini L.F. (Mamm. Genome 1993) 3 4 22 64
  5. Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere. (PMID: 8475094) Vickers M.A. … Higgs D.R. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 22 64

Products for MPG Gene

Sources for MPG Gene

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