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Aliases for MPG Gene

Aliases for MPG Gene

  • N-Methylpurine DNA Glycosylase 2 3 5
  • 3-Methyladenine DNA Glycosidase 3 4
  • 3-Alkyladenine DNA Glycosylase 3 4
  • Mid1 3 4
  • Anpg 3 4
  • ADPG 3 4
  • AAG 3 4
  • 3 End Of The Mid1 Gene, Localized 68 Kb Upstream The Humanzeta Globin Gene On 16p 3
  • CRA36.1 (3-Methyl-Adenine DNA Glycosylase) 3
  • N-Methylpurine-DNA Glycosylase, MPG 3
  • Proliferation-Inducing Protein 11 3
  • Proliferation-Inducing Protein 16 3
  • DNA-3-Methyladenine Glycosylase 3
  • N-Methylpurine-DNA Glycosylase 4
  • Alkyladenine DNA Glycosylase 2
  • EC 3.2.2.21 4
  • CRA36.1 3
  • PIG11 3
  • PIG16 3
  • APNG 3
  • MDG 3

External Ids for MPG Gene

Previous GeneCards Identifiers for MPG Gene

  • GC16P000148
  • GC16P000067
  • GC16P000069
  • GC16P000068
  • GC16P000127
  • GC16P000046
  • GC16P000087
  • GC16P000097
  • GC16P000108
  • GC16P000116
  • GC16P000123
  • GC16P000129

Summaries for MPG Gene

GeneCards Summary for MPG Gene

MPG (N-Methylpurine DNA Glycosylase) is a Protein Coding gene. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Recognition and association of DNA glycosylase with site containing an affected purine. GO annotations related to this gene include damaged DNA binding and DNA-3-methyladenine glycosylase activity.

UniProtKB/Swiss-Prot for MPG Gene

  • Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

Gene Wiki entry for MPG Gene

Additional gene information for MPG Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPG Gene

Genomics for MPG Gene

Regulatory Elements for MPG Gene

Enhancers for MPG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H000323 2 FANTOM5 Ensembl ENCODE dbSUPER 22.2 +249.4 249426 5 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF416 ZNF207 FOS WDR90 LUC7L JMJD8 UBE2I ENSG00000228779 ENSG00000261505 RHOT2 WDR24 ENSG00000262528 MPG
GH16H000981 1.2 ENCODE dbSUPER 21.9 +904.5 904469 0 ZNF493 ZNF133 GLI4 ZNF2 GLIS2 ZNF416 KLF7 ZNF548 SP3 MCM3 WDR90 CRAMP1 ENSG00000261505 UBE2I JMJD8 TELO2 ENSG00000260954 UNKL ENSG00000260051 WDR24
GH16H000066 1.8 FANTOM5 ENCODE dbSUPER 12.1 -3.5 -3506 13 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF143 WASH4P WDR90 RHOT2 ENSG00000268836 LUC7L CHTF18 NPRL3 WDR24 RHBDF1 CAPN15
GH16H000104 1.3 FANTOM5 ENCODE dbSUPER 12.3 +27.8 27776 0 TAL1 MAX YY1 TCF12 ZNF316 GATA2 NCOR1 TRIM24 NFE2 MAFK HBM ENSG00000228779 NPRL3 HBZ RHBDF1 MPG HBQ1 SNRNP25 NHLRC4 GC16P000124
GH16H000635 1.4 ENCODE dbSUPER 10.7 +560.1 560066 4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 METTL26 WDR90 CRAMP1 WFIKKN1 JMJD8 ENSG00000261505 UBE2I TELO2 NARFL ENSG00000226890
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MPG on UCSC Golden Path with GeneCards custom track

Promoters for MPG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082121 1193 1201 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B GLIS2 SP3 SP5

Transcription factor binding sites by QIAGEN in the MPG gene promoter:

Genomic Location for MPG Gene

Chromosome:
16
Start:
77,007 bp from pter
End:
85,853 bp from pter
Size:
8,847 bases
Orientation:
Plus strand

Genomic View for MPG Gene

Genes around MPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPG Gene

Proteins for MPG Gene

  • Protein details for MPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29372-3MG_HUMAN
    Recommended name:
    DNA-3-methyladenine glycosylase
    Protein Accession:
    P29372
    Secondary Accessions:
    • G5E9E2
    • Q13770
    • Q15275
    • Q15961
    • Q5J9I4
    • Q96BZ6
    • Q96S33
    • Q9NNX5

    Protein attributes for MPG Gene

    Size:
    298 amino acids
    Molecular mass:
    32869 Da
    Quaternary structure:
    • Binds MBD1. Binds SSBP1.

    Three dimensional structures from OCA and Proteopedia for MPG Gene

    Alternative splice isoforms for MPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPG Gene

Post-translational modifications for MPG Gene

  • Ubiquitination at posLast=8080 and posLast=229229
  • Modification sites at PhosphoSitePlus

Other Protein References for MPG Gene

No data available for DME Specific Peptides for MPG Gene

Domains & Families for MPG Gene

Gene Families for MPG Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MPG Gene

Suggested Antigen Peptide Sequences for MPG Gene

Graphical View of Domain Structure for InterPro Entry

P29372

UniProtKB/Swiss-Prot:

3MG_HUMAN :
  • Belongs to the DNA glycosylase MPG family.
Family:
  • Belongs to the DNA glycosylase MPG family.
genes like me logo Genes that share domains with MPG: view

Function for MPG Gene

Molecular function for MPG Gene

GENATLAS Biochemistry:
DNA glycosylase,3-methyl-adenine,base excision repair
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Binding to SSBP1 in mitochondria inhibits glycosylase activity in the context of a single-stranded DNA (ssDNA), but not a double-stranded DNA (dsDNA) substrates.
UniProtKB/Swiss-Prot Function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

Enzyme Numbers (IUBMB) for MPG Gene

Phenotypes From GWAS Catalog for MPG Gene

Gene Ontology (GO) - Molecular Function for MPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003684 damaged DNA binding TAS 10854423
GO:0003824 catalytic activity IEA --
GO:0003905 alkylbase DNA N-glycosylase activity IBA --
GO:0005515 protein binding IPI 18482256
GO:0008725 DNA-3-methyladenine glycosylase activity IEA --
genes like me logo Genes that share ontologies with MPG: view
genes like me logo Genes that share phenotypes with MPG: view

Animal Models for MPG Gene

MGI Knock Outs for MPG:

Animal Model Products

CRISPR Products

miRNA for MPG Gene

miRTarBase miRNAs that target MPG

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MPG Gene

Localization for MPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPG Gene

Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPG gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytoskeleton 2
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MPG: view

Pathways & Interactions for MPG Gene

genes like me logo Genes that share pathways with MPG: view

Pathways by source for MPG Gene

Gene Ontology (GO) - Biological Process for MPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006284 base-excision repair TAS 10854423
GO:0006307 DNA dealkylation involved in DNA repair TAS 1645538
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0045007 depurination TAS --
genes like me logo Genes that share ontologies with MPG: view

No data available for SIGNOR curated interactions for MPG Gene

Drugs & Compounds for MPG Gene

(17) Drugs for MPG Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Target Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2823
Zinc Approved Pharma Target 2359
Loperamide Approved Pharma 151
3-Methyladenine Experimental Pharma Class III PI3K inhibitor, Class III PI 3-kinase inhibitor; also inhibits autophagy 0

(21) Additional Compounds for MPG Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Methylguanine
  • 3-Methyl-Guanine (VAN) (8CI)
  • 3-Methylguanine
  • 7-Dihydro-3-methyl-2-amino-3-6H-Purin-6-one
  • 7-Dihydro-3-methyl-2-amino-3-6H-Purin-6-one (9CI)
  • N3-Methylguanine
2958-98-7
7-Methylguanine
  • 2-Amino-1,7-dihydroxy-7-methyl-6H-purine-6-one
  • 2-Amino-6-hydroxy-7-methylpurine
  • 2-Amino-7-methylhypoxanthine
  • 7-Methyl-Guanine
  • 7-Methyl-Guanine (8CI)
578-76-7
7-Methyladenine
  • 6-Amino-7-methylpurine
  • 7-Methyl-7H-purin-6-amine
  • 7-Methyl-7H-purin-6-amine (ACD/Name 4.0)
  • 7-Methyl-7H-purin-6-ylamine (ACD/Name 4.0)
  • 7-Methyl-N7-Methyladenine
935-69-3
genes like me logo Genes that share compounds with MPG: view

Transcripts for MPG Gene

Unigene Clusters for MPG Gene

N-methylpurine-DNA glycosylase:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPG Gene

No ASD Table

Relevant External Links for MPG Gene

GeneLoc Exon Structure for
MPG
ECgene alternative splicing isoforms for
MPG

Expression for MPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MPG Gene

Protein differential expression in normal tissues from HIPED for MPG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.3), Blymphocyte (7.0), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MPG Gene



Protein tissue co-expression partners for MPG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MPG Gene:

MPG

SOURCE GeneReport for Unigene cluster for MPG Gene:

Hs.459596

Evidence on tissue expression from TISSUES for MPG Gene

  • Liver(4.4)
  • Pancreas(4.3)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with MPG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPG Gene

Orthologs for MPG Gene

This gene was present in the common ancestor of chordates.

Orthologs for MPG Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MPG 33 34
  • 82.73 (n)
chimpanzee
(Pan troglodytes)
Mammalia MPG 34
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MPG 33 34
  • 80.75 (n)
mouse
(Mus musculus)
Mammalia Mpg 33 16 34
  • 79.36 (n)
rat
(Rattus norvegicus)
Mammalia Mpg 33
  • 77.08 (n)
oppossum
(Monodelphis domestica)
Mammalia MPG 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves MPG 33 34
  • 63.76 (n)
lizard
(Anolis carolinensis)
Reptilia MPG 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC549932 33
  • 58.52 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16168 33
zebrafish
(Danio rerio)
Actinopterygii mpg 33 34
  • 59.76 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
OneToOne
Species where no ortholog for MPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPG Gene

ENSEMBL:
Gene Tree for MPG (if available)
TreeFam:
Gene Tree for MPG (if available)

Paralogs for MPG Gene

No data available for Paralogs for MPG Gene

Variants for MPG Gene

Sequence variations from dbSNP and Humsavar for MPG Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000087335 -- 75,536(+) GCCAG(A/C/G)CCAGC intron-variant, upstream-variant-2KB
rs1000251699 -- 82,400(+) AGGGG(A/G)TGTGG intron-variant
rs1001042935 -- 78,998(+) CTGTG(C/T)TTTGA intron-variant
rs1001470245 -- 79,567(+) GCGCT(C/G)CTTGG reference, missense
rs1001673947 -- 78,709(+) CAGGC(C/G)GGCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPG Gene

Variant ID Type Subtype PubMed ID
dgv2688n100 CNV gain 25217958
dgv2689n100 CNV gain 25217958
dgv2690n100 CNV gain 25217958
esv1240373 CNV deletion 17803354
esv1393228 CNV insertion 17803354
esv2422427 CNV duplication 17116639
esv26636 CNV gain+loss 19812545
esv2760065 CNV gain 17122850
esv32706 CNV loss 17666407
esv3637536 CNV loss 21293372
esv3637537 CNV gain 21293372
esv996836 CNV insertion 20482838
nsv1044142 CNV gain 25217958
nsv1045829 CNV gain 25217958
nsv518291 CNV loss 19592680
nsv570924 CNV loss 21841781
nsv820705 CNV duplication 20802225
nsv9317 CNV gain 18304495

Variation tolerance for MPG Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPG Gene

Human Gene Mutation Database (HGMD)
MPG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MPG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPG Gene

Disorders for MPG Gene

Relevant External Links for MPG

Genetic Association Database (GAD)
MPG
Human Genome Epidemiology (HuGE) Navigator
MPG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MPG

No disorders were found for MPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPG Gene

Publications for MPG Gene

  1. Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase. (PMID: 1874728) Chakravarti D … Mitra S (The Journal of biological chemistry 1991) 2 3 4 22 60
  2. Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin. (PMID: 14555760) Watanabe S … Nakao M (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 22 60
  3. Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision. (PMID: 9790531) Lau AY … Ellenberger T (Cell 1998) 3 4 22 60
  4. Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere. (PMID: 8475094) Vickers MA … Higgs DR (Proceedings of the National Academy of Sciences of the United States of America 1993) 3 4 22 60
  5. Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse. (PMID: 8318735) Kielman MF … Bernini LF (Mammalian genome : official journal of the International Mammalian Genome Society 1993) 3 4 22 60

Products for MPG Gene

  • Addgene plasmids for MPG

Sources for MPG Gene

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