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MPG Gene

protein-coding   GIFtS: 64
GCID: GC16P000127

N-Methylpurine-DNA Glycosylase

  See MPG-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N-Methylpurine-DNA Glycosylase1 2 3     PIG112
3-Alkyladenine DNA Glycosylase2 3     PIG162
3-Methyladenine DNA Glycosidase2 3     anpg2
AAG2 3     CRA36.1 (3-Methyl-Adenine DNA Glycosylase)2
ADPG2 3     DNA-3-Methyladenine Glycosylase2
MDG2 5     N-Methylpurine-DNA Glycosylase, MPG2
Alkyladenine DNA Glycosylase1     Proliferation-Inducing Protein 112
3' End Of The Mid1 Gene, Localized 68 Kb Upstream The Humanzeta Globin
Gene On 16p2
     Proliferation-Inducing Protein 162
APNG2     ANPG3
CRA36.12     EC 3.2.2.213
Mid12     MID13

External Ids:    HGNC: 72111   Entrez Gene: 43502   Ensembl: ENSG000001031527   OMIM: 1565655   UniProtKB: P293723   

Export aliases for MPG gene to outside databases

Previous GC identifers: GC16P000148 GC16P000067 GC16P000069 GC16P000068 GC16P000046


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MPG Gene:
MPG (N-methylpurine-DNA glycosylase) is a protein-coding gene. Diseases associated with MPG include familial colorectal cancer. GO annotations related to this gene include damaged DNA binding and DNA-7-methylguanine glycosylase activity.

UniProtKB/Swiss-Prot: 3MG_HUMAN, P29372
Function: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the
damaged DNA polymer formed by alkylation lesions

Gene Wiki entry for MPG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MPG gene promoter:
         STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMPG promoter sequence
   Search Chromatin IP Primers for MPG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MPG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

MPG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPG gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P000127:  view genomic region     (about GC identifiers)

Start:
127,006 bp from pter      End:
135,852 bp from pter
Size:
8,847 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 3MG_HUMAN, P29372 (See protein sequence)
Recommended Name: DNA-3-methyladenine glycosylase  
Size: 298 amino acids; 32869 Da
Subunit: Binds MBD1
6 PDB 3D structures from and Proteopedia for MPG:
1BNK (3D)        1EWN (3D)        1F4R (3D)        1F6O (3D)        3QI5 (3D)        3UBY (3D)    
Secondary accessions: G5E9E2 Q13770 Q15275 Q15961 Q5J9I4 Q96BZ6 Q96S33 Q9NNX5
Alternative splicing: 4 isoforms:  P29372-1   P29372-2   P29372-4   P29372-5   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for MPG: NX_P29372

Explore proteomics data for MPG at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys80, Lys229
  • Modification sites at PhosphoSitePlus

  • See MPG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001015052.1  NP_001015054.1  NP_002425.2  

    ENSEMBL proteins: 
     ENSP00000388097   ENSP00000348809   ENSP00000219431   ENSP00000380918  
    Reactome Protein details: P29372

    MPG Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for MPG
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    Novus Biologicals MPG Proteins
    Novus Biologicals MPG Lysates
    Browse Sino Biological Recombinant Proteins
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    ProSpec Recombinant Protein for MPG
    Cloud-Clone Corp. Proteins for MPG

     
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    MPG Assay Products:

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    Cloud-Clone Corp. CLIAs for MPG
    Search eBioscience for ELISAs for MPG 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011034 Formyl_transferase_C-like
     IPR003180 PurDNA_glycsylse

    Graphical View of Domain Structure for InterPro Entry P29372

    ProtoNet protein and cluster: P29372

    1 Blocks protein domain: IPB003180 Methylpurine-DNA glycosylase (MPG)

    UniProtKB/Swiss-Prot: 3MG_HUMAN, P29372
    Similarity: Belongs to the DNA glycosylase MPG family


    Find genes that share domains with MPG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 3MG_HUMAN, P29372
    Function: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the
    damaged DNA polymer formed by alkylation lesions
    Catalytic activity: Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and
    7-methyladenine

         Genatlas biochemistry entry for MPG:
    DNA glycosylase,3-methyl-adenine,base excision repair

         Enzyme Number (IUBMB): EC 3.2.2.211

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003684damaged DNA binding TAS10854423
    GO:0003824catalytic activity ----
    GO:0003905alkylbase DNA N-glycosylase activity ----
    GO:0005515protein binding IPI18482256
         
    Find genes that share ontologies with MPG           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for MPG:
     Decreased G3BP1 protein expres  Decreased circadian period len  Decreased influenza A virus in 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mpg):
     adipose tissue  cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  tumorigenesis 

    Find genes that share phenotypes with MPG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MPG: Mpgtm1Rhe Mpgtm1Lds

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MPG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MPG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MPG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MPG

    miRNA
    Products:
        
    miRTarBase miRNAs that target MPG:
    hsa-mir-92a-3p (MIRT049590), hsa-let-7b-5p (MIRT032215), hsa-mir-93-5p (MIRT048882)

    Block miRNA regulation of human, mouse, rat MPG using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MPG
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MPG

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MPG (NM_001563)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPG
    Addgene plasmids for MPG 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    3MG_HUMAN, P29372: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    chloroplast2
    cytoskeleton2
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with MPG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MPG About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Resolution of Abasic Sites (AP sites)
    Resolution of Abasic Sites (AP sites)0.89
    Base Excision Repair0.00
    Resolution of AP sites via the multiple-nucleotide patch replacement pathway0.89
    Displacement of DNA glycosylase by APE10.00
    Base excision repair0.53
    Resolution of AP sites via the single-nucleotide replacement pathway0.00
    Base-Excision Repair, AP Site Formation0.00
    Removal of DNA patch containing abasic residue0.00
    2Depurination
    Depurination
    Cleavage of the damaged purine0.00
    Recognition and association of DNA glycosylase with site containing an affected purine0.00
    3DNA Repair
    DNA Repair0.45
    4Busulfan Pathway, Pharmacodynamics
    Busulfan Pathway, Pharmacodynamics


    Find genes that share SuperPaths with MPG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for MPG
        Displacement of DNA glycosylase by APE1
    Recognition and association of DNA glycosylase with site containing an affected purine
    Cleavage of the damaged purine

    1 PharmGKB Pathway for MPG
        Busulfan Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for MPG):
        Base excision repair

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MPG: 
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MPG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MPG (P293721, 2, 3 ENSP000002194314) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRNPP041561, 3EBI-1043398,EBI-977302 I2D: score=1 
    XRCC1P188872, 3, ENSP000002628874MINT-7294862 I2D: score=1 STRING: ENSP00000262887
    RAD23AP547253, ENSP000003213654I2D: score=2 STRING: ENSP00000321365
    CAPZA1P529073, ENSP000002631684I2D: score=1 STRING: ENSP00000263168
    MIFP141743, ENSP000002157544I2D: score=1 STRING: ENSP00000215754
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS--
    GO:0006284base-excision repair TAS--
    GO:0006285base-excision repair, AP site formation TAS--
    GO:0006307DNA dealkylation involved in DNA repair TAS1645538
    GO:0045007depurination TAS--

    Find genes that share ontologies with MPG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MPG (3MG)

    5 HMDB Compounds for MPG    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Methyladenine3-methyl-3H-Purin-6-amine (see all 5)5142-23-4--
    3-MethylguanineN3-Methylguanine (see all 5)2958-98-7--
    7-Methyladenine7-Methyl-7H-purin-6-amine (see all 6)935-69-3--
    7-Methylguanine2-Amino-6-hydroxy-7-methylpurine (see all 8)578-76-7--
    LoperamideApo-Loperamide (see all 10)53179-11-6--

    Selected Novoseek inferred chemical compound relationships for MPG gene (see all 35)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1,n6-ethenoadenine 97.4 29 1409645 (2), 10891085 (2), 12202763 (1), 10626225 (1) (see all 18)
    3-methyladenine 96.5 99 9895121 (5), 8475094 (4), 15651853 (4), 8435858 (4) (see all 44)
    3-methylguanine 94.5 7 1874728 (1), 14729667 (1), 7528899 (1), 8435858 (1) (see all 5)
    7-methylguanine 93.2 19 9813117 (2), 15651853 (2), 1874728 (1), 19219989 (1) (see all 11)
    apng 92.3 13 12202763 (4), 16290249 (3), 10626224 (2), 9837917 (2) (see all 5)
    hypoxanthine 83 69 17716976 (5), 19219989 (3), 17655363 (3), 19449863 (2) (see all 21)
    3,n(4)-ethenocytosine 77.8 1 14761949 (1)
    o6-methylguanine 74.9 3 11410664 (1), 18992265 (1), 9103402 (1)
    chloroethyl nitrosoureas 74.4 2 7605343 (1), 12663522 (1)
    methylmethanesulfonate 74.1 12 1874728 (2), 18992265 (2), 12566303 (2), 16288039 (2) (see all 6)



    Find genes that share compounds with MPG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MPG gene (3 alternative transcripts): 
    NM_001015052.2  NM_001015054.2  NM_002434.3  

    Unigene Cluster for MPG:

    N-methylpurine-DNA glycosylase
    Hs.459596  [show with all ESTs]
    Unigene Representative Sequence: BF572325
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436333 ENST00000356432(uc010bqp.3 uc002cfo.3) ENST00000475280
    ENST00000219431(uc002cfn.3) ENST00000397817(uc002cfm.3)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat MPG

    Additional mRNA sequence: 

    AK308654.1 AY258284.1 BC014991.1 L10752.1 M71215.1 M74905.1 M99626.1 S51033.1 
    X56528.1 

    14 DOTS entries:

    DT.100042094  DT.444615  DT.100782934  DT.92446754  DT.95292872  DT.120688508  DT.95092525  DT.120688515 
    DT.100782930  DT.100782931  DT.101956434  DT.121645427  DT.95226846  DT.95246148 

    Selected AceView cDNA sequences (see all 263):

    BM854974 CA488184 BI870400 W24112 BQ927180 AA299077 F04542 BU631253 
    AI131317 CB044049 BE909470 AI754347 CR619346 CR612592 AW024618 N91934 
    AA115941 BQ676405 BM552363 BI791744 BQ684616 BQ888825 AI565950 BI524092 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MPG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGGGAGTG
    MPG Expression
    About this image

    MPG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MPG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.459596
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MPG: 
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MPG gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mpg1 , 5 N-methylpurine-DNA glycosylase1, 5 79.36(n)1
    81.15(a)1
      11 (18.83 cM)5
    2683951  NM_010822.31  NP_034952.21 
     322265055 
    chicken
    (Gallus gallus)
    Aves MPG1 N-methylpurine-DNA glycosylase 63.76(n)
    60.17(a)
      416648  XM_414945.4  XP_414945.3 
    lizard
    (Anolis carolinensis)
    Reptilia MPG6
    N-methylpurine-DNA glycosylase
    56(a)
    1 ↔ 1
    AAWZ02037681(14519-15066)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.161682 Xenopus laevis transcribed sequence with weak similarity more 71.09(n)    BJ045678.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mpg1 N-methylpurine-DNA glycosylase 59.76(n)
    60.98(a)
      566516  NM_001082850.1  NP_001076319.1 


    ENSEMBL Gene Tree for MPG (if available)
    TreeFam Gene Tree for MPG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MPG (see all 403)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1163364051,2
    C,F--125019(+) GGACGC/TGCACG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1484462031,2
    --125024(+) CGCACA/GAAACT 1 -- us2k10--------
    rs1848897301,2
    --125053(+) ACATAA/GACAAG 1 -- us2k10--------
    rs1898206641,2
    --125054(+) CATAGA/CCAAGT 1 -- us2k10--------
    rs753076411,2
    F--125128(+) CCCCTA/GTACGG 1 -- us2k11Minor allele frequency- G:0.08WA 118
    rs25621571,2
    C,F--125181(+) GGAGAA/GATGGA 1 -- us2k1 tfbs31Minor allele frequency- G:0.04WA 118
    rs801732071,2
    C,F--125231(+) CAGGCG/ATCTGA 1 -- us2k13Minor allele frequency- A:0.06WA NA EA 358
    rs1150072131,2
    C,F--125285(+) GCCCTC/TACACC 1 -- us2k13Minor allele frequency- T:0.07WA NA EA 358
    rs25416351,2
    C,F,A--125342(-) GGGTAC/GCTGTT 1 -- us2k110Minor allele frequency- G:0.48NA CSA WA EA 372
    rs1172475381,2
    C,F--125424(+) CCTGGG/ACTTTG 1 -- us2k11Minor allele frequency- A:0.03EA 120

    HapMap Linkage Disequilibrium report for MPG (127006 - 135852 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MPG (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1240373CNV Deletion17803354
    nsv820705CNV Duplication20802225
    esv2422427CNV Duplication17116639
    esv996836CNV Insertion20482838
    esv1393228CNV Insertion17803354
    nsv904628CNV Loss21882294
    nsv904631CNV Loss21882294
    nsv904634CNV Loss21882294
    esv32706CNV Loss17666407
    dgv2456n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): MPG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MPG
    DNA2.0 Custom Variant and Variant Library Synthesis for MPG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 156565    OMIM disorders: --

    1 disease for MPG:    
    About MalaCards
    familial colorectal cancer


    Find genes that share disorders with MPG           About GenesLikeMe

    10 Novoseek inferred disease relationships for MPG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chromosomal aberrations 20.6 3 7528899 (2), 9731510 (1)
    cancer lung 5.59 3 10477488 (2)
    inflammation 0 1 14679184 (1)
    glioma 0 1 17255284 (1)
    breast cancer 0 14 9684856 (2), 15299078 (2), 10563836 (2), 12566303 (2) (see all 5)
    ovarian cancer 0 2 17200364 (1)
    nsclc 0 5 16613673 (2), 10477488 (1)
    tumors 0 38 12820404 (8), 11724299 (4), 12014652 (4), 16288039 (2) (see all 10)
    carcinoma 0 5 11724299 (2), 12014652 (1), 16288039 (1)
    cancer 0 6 16834910 (1), 15299078 (1), 8611396 (1)

    Genetic Association Database (GAD): MPG
    Human Genome Epidemiology (HuGE) Navigator: MPG (16 documents)

    Export disorders for MPG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for MPG gene, integrated from 10 sources (see all 176):
    (articles sorted by number of sources associating them with MPG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase. (PubMed id 1874728)1, 2, 3, 9 Chakravarti D.... Mitra S. (J. Biol. Chem. 1991)
    2. Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin. (PubMed id 14555760)1, 2, 9 Watanabe S.... Nakao M. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    3. Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere. (PubMed id 8475094)1, 2, 9 Vickers M.A.... Higgs D.R. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    4. Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse. (PubMed id 8318735)1, 2, 9 Kielman M.F.... Bernini L.F. (Mamm. Genome 1993)
    5. Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision. (PubMed id 9790531)1, 2, 9 Lau A.Y.... Ellenberger T. (Cell 1998)
    6. Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16. (PubMed id 1924375)1, 2, 9 Samson L.... Call K. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    7. Genetic polymorphisms of the DNA repair gene MPG may be associated with susceptibility to rheumatoid arthritis. (PubMed id 21063071)1, 4 Chen S.Y....Tsai F.J. (J. Appl. Genet. 2010)
    8. Polymorphisms in the base excision repair pathway and graft-versus-host disease. (PubMed id 20574454)1, 4 Arora M....Thyagarajan B. (Leukemia 2010)
    9. Variation within DNA repair pathway genes and risk of multiple sclerosis. (PubMed id 20522537)1, 4 Briggs F.B....Barcellos L.F. (Am. J. Epidemiol. 2010)
    10. Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations. (PubMed id 20226869)1, 4 Thyagarajan B....Arora M. (Biol. Blood Marrow Transplant. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 4350 HGNC: 7211 AceView: MPG Ensembl:ENSG00000103152 euGenes: HUgn4350
    ECgene: MPG Kegg: 4350 H-InvDB: MPG

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MPG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MPG Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mpg/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MPG gene:
    Search GeneIP for patents involving MPG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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