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Aliases for MPG Gene

Aliases for MPG Gene

  • N-Methylpurine DNA Glycosylase 2 3
  • 3-Methyladenine DNA Glycosidase 3 4
  • 3-Alkyladenine DNA Glycosylase 3 4
  • Mid1 3 4
  • Anpg 3 4
  • ADPG 3 4
  • AAG 3 4
  • 3 End Of The Mid1 Gene, Localized 68 Kb Upstream The Humanzeta Globin Gene On 16p 3
  • CRA36.1 (3-Methyl-Adenine DNA Glycosylase) 3
  • N-Methylpurine-DNA Glycosylase, MPG 3
  • Proliferation-Inducing Protein 11 3
  • Proliferation-Inducing Protein 16 3
  • N-Methylpurine-DNA Glycosylase 4
  • Alkyladenine DNA Glycosylase 2
  • EC 3.2.2.21 4
  • CRA36.1 3
  • PIG11 3
  • PIG16 3
  • APNG 3
  • MDG 3

External Ids for MPG Gene

Previous GeneCards Identifiers for MPG Gene

  • GC16P000148
  • GC16P000067
  • GC16P000069
  • GC16P000068
  • GC16P000127
  • GC16P000046
  • GC16P000087

Summaries for MPG Gene

GeneCards Summary for MPG Gene

MPG (N-Methylpurine DNA Glycosylase) is a Protein Coding gene. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include damaged DNA binding and DNA-3-methyladenine glycosylase activity.

UniProtKB/Swiss-Prot for MPG Gene

  • Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions

Gene Wiki entry for MPG Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPG Gene

Genomics for MPG Gene

Regulatory Elements for MPG Gene

Transcription factor binding sites by QIAGEN in the MPG gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MPG Gene

Chromosome:
16
Start:
77,007 bp from pter
End:
85,853 bp from pter
Size:
8,847 bases
Orientation:
Plus strand

Genomic View for MPG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPG Gene

Proteins for MPG Gene

  • Protein details for MPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29372-3MG_HUMAN
    Recommended name:
    DNA-3-methyladenine glycosylase
    Protein Accession:
    P29372
    Secondary Accessions:
    • G5E9E2
    • Q13770
    • Q15275
    • Q15961
    • Q5J9I4
    • Q96BZ6
    • Q96S33
    • Q9NNX5

    Protein attributes for MPG Gene

    Size:
    298 amino acids
    Molecular mass:
    32869 Da
    Quaternary structure:
    • Binds MBD1. Binds SSBP1

    Three dimensional structures from OCA and Proteopedia for MPG Gene

    Alternative splice isoforms for MPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPG Gene

Proteomics data for MPG Gene at MOPED

Post-translational modifications for MPG Gene

  • Ubiquitination at Lys 80 and Lys 229
  • Modification sites at PhosphoSitePlus

Other Protein References for MPG Gene

Antibody Products

No data available for DME Specific Peptides for MPG Gene

Domains & Families for MPG Gene

Gene Families for MPG Gene

Protein Domains for MPG Gene

Suggested Antigen Peptide Sequences for MPG Gene

Graphical View of Domain Structure for InterPro Entry

P29372

UniProtKB/Swiss-Prot:

3MG_HUMAN :
  • Belongs to the DNA glycosylase MPG family.
Family:
  • Belongs to the DNA glycosylase MPG family.
genes like me logo Genes that share domains with MPG: view

Function for MPG Gene

Molecular function for MPG Gene

GENATLAS Biochemistry:
DNA glycosylase,3-methyl-adenine,base excision repair
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine
UniProtKB/Swiss-Prot EnzymeRegulation:
Binding to SSBP1 in mitochondria inhibits glycosylase activity in the context of a single-stranded DNA (ssDNA), but not a double-stranded DNA (dsDNA) substrates.
UniProtKB/Swiss-Prot Function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions

Enzyme Numbers (IUBMB) for MPG Gene

Gene Ontology (GO) - Molecular Function for MPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003684 damaged DNA binding TAS 10854423
GO:0003824 catalytic activity --
GO:0003905 alkylbase DNA N-glycosylase activity IBA --
GO:0005515 protein binding IPI 18482256
genes like me logo Genes that share ontologies with MPG: view
genes like me logo Genes that share phenotypes with MPG: view

Animal Models for MPG Gene

MGI Knock Outs for MPG:

Animal Model Products

miRNA for MPG Gene

miRTarBase miRNAs that target MPG

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPG

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MPG Gene

Localization for MPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPG Gene

Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MPG Gene COMPARTMENTS Subcellular localization image for MPG gene
Compartment Confidence
nucleus 4
mitochondrion 3
chloroplast 2
cytoskeleton 2
cytosol 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0042645 mitochondrial nucleoid IEA --
genes like me logo Genes that share ontologies with MPG: view

Pathways & Interactions for MPG Gene

genes like me logo Genes that share pathways with MPG: view

Pathways by source for MPG Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for MPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006284 base-excision repair TAS --
GO:0006285 base-excision repair, AP site formation TAS --
GO:0006307 DNA dealkylation involved in DNA repair TAS 1645538
GO:0045007 depurination TAS --
genes like me logo Genes that share ontologies with MPG: view

No data available for SIGNOR curated interactions for MPG Gene

Drugs & Compounds for MPG Gene

(16) Drugs for MPG Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Loperamide Approved Pharma 104
Busulfan Approved, Investigational Pharma 486
Chlorambucil Approved Pharma 52
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Mechlorethamine Approved Pharma 410

(21) Additional Compounds for MPG Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Methylguanine
  • 3-Methyl-Guanine (VAN) (8CI)
  • 3-Methylguanine
  • 7-Dihydro-3-methyl-2-amino-3-6H-Purin-6-one
  • 7-Dihydro-3-methyl-2-amino-3-6H-Purin-6-one (9CI)
  • N3-Methylguanine
2958-98-7
7-Methylguanine
  • 2-Amino-1,7-dihydroxy-7-methyl-6H-purine-6-one
  • 2-Amino-6-hydroxy-7-methylpurine
  • 2-Amino-7-methylhypoxanthine
  • 7-Methyl-Guanine
  • 7-Methyl-Guanine (8CI)
578-76-7
7-Methyladenine
  • 6-Amino-7-methylpurine
  • 7-Methyl-7H-purin-6-amine
  • 7-Methyl-7H-purin-6-amine (ACD/Name 4.0)
  • 7-Methyl-7H-purin-6-ylamine (ACD/Name 4.0)
  • 7-Methyl-N7-Methyladenine
935-69-3
3,n(4)-ethenocytosine
8-Oxoguanine
  • 2-Amino-1H-purine-6,8-dione
  • 8-OXOGUANINE
82014-86-6
genes like me logo Genes that share compounds with MPG: view

Transcripts for MPG Gene

Unigene Clusters for MPG Gene

N-methylpurine-DNA glycosylase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPG Gene

No ASD Table

Relevant External Links for MPG Gene

GeneLoc Exon Structure for
MPG
ECgene alternative splicing isoforms for
MPG

Expression for MPG Gene

mRNA expression in normal human tissues for MPG Gene

Protein differential expression in normal tissues from HIPED for MPG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.3), Blymphocyte (7.0), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPG Gene



SOURCE GeneReport for Unigene cluster for MPG Gene Hs.459596

genes like me logo Genes that share expression patterns with MPG: view

Protein tissue co-expression partners for MPG Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MPG Gene

Orthologs for MPG Gene

This gene was present in the common ancestor of chordates.

Orthologs for MPG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MPG 35
  • 80.75 (n)
  • 78.7 (a)
MPG 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MPG 35
  • 82.73 (n)
  • 82.01 (a)
MPG 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mpg 35
  • 79.36 (n)
  • 81.15 (a)
Mpg 16
Mpg 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mpg 35
  • 77.08 (n)
  • 78.07 (a)
oppossum
(Monodelphis domestica)
Mammalia MPG 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MPG 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves MPG 35
  • 63.76 (n)
  • 60.17 (a)
MPG 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MPG 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC549932 35
  • 58.52 (n)
  • 60.63 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16168 35
zebrafish
(Danio rerio)
Actinopterygii mpg 35
  • 59.76 (n)
  • 60.98 (a)
mpg 36
  • 48 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for MPG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPG Gene

ENSEMBL:
Gene Tree for MPG (if available)
TreeFam:
Gene Tree for MPG (if available)

Paralogs for MPG Gene

No data available for Paralogs for MPG Gene

Variants for MPG Gene

Sequence variations from dbSNP and Humsavar for MPG Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2858049 -- 83,614(+) TGGGC(A/T)CCTGT intron-variant
rs3176421 -- 83,689(+) ggagc(C/G)aagat intron-variant
rs3176422 -- 83,709(+) gcact(C/G)cagcc intron-variant
rs3176423 -- 83,767(+) gaaaa(G/T)aaaGG intron-variant
rs55674146 -- 83,755(+) AAAAA(-/AA)GGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPG Gene

Variant ID Type Subtype PubMed ID
nsv904623 CNV Gain+Loss 21882294
dgv2455n71 CNV Loss 21882294
esv2422427 CNV Duplication 17116639
dgv789e1 CNV Complex 17122850
nsv518291 CNV Loss 19592680
dgv2456n71 CNV Loss 21882294
nsv904628 CNV Loss 21882294
dgv2457n71 CNV Loss 21882294
nsv904631 CNV Loss 21882294
esv32706 CNV Loss 17666407
nsv9317 CNV Gain 18304495
esv26636 CNV Gain+Loss 19812545
nsv820705 CNV Duplication 20802225
esv1240373 CNV Deletion 17803354
esv996836 CNV Insertion 20482838
esv1393228 CNV Insertion 17803354
nsv904634 CNV Loss 21882294

Variation tolerance for MPG Gene

Residual Variation Intolerance Score: 75.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPG Gene

HapMap Linkage Disequilibrium report
MPG
Human Gene Mutation Database (HGMD)
MPG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPG Gene

Disorders for MPG Gene

Relevant External Links for MPG

Genetic Association Database (GAD)
MPG
Human Genome Epidemiology (HuGE) Navigator
MPG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MPG
genes like me logo Genes that share disorders with MPG: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPG Gene

Publications for MPG Gene

  1. Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase. (PMID: 1874728) Chakravarti D. … Mitra S. (J. Biol. Chem. 1991) 2 23 67
  2. Hopping enables a DNA repair glycosylase to search both strands and bypass a bound protein. (PMID: 20201599) Hedglin M. … O'Brien P.J. (ACS Chem. Biol. 2010) 23 67
  3. Frameshift mutagenesis and microsatellite instability induced by human alkyladenine DNA glycosylase. (PMID: 20347426) Klapacz J. … Samson L.D. (Mol. Cell 2010) 23 67
  4. Excised damaged base determines the turnover of human N-methylpurine-DNA glycosylase. (PMID: 19616486) Adhikari S. … Roy R. (DNA Repair (Amst.) 2009) 23 67
  5. Kinetic mechanism for the flipping and excision of 1,N(6)-ethenoadenine by human alkyladenine DNA glycosylase. (PMID: 19883114) Wolfe A.E. … O'Brien P.J. (Biochemistry 2009) 23 67

Products for MPG Gene

Sources for MPG Gene

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