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Aliases for MPG Gene

Aliases for MPG Gene

  • N-Methylpurine-DNA Glycosylase 2 3 4
  • 3-Methyladenine DNA Glycosidase 3 4
  • 3-Alkyladenine DNA Glycosylase 3 4
  • Mid1 3 4
  • Anpg 3 4
  • ADPG 3 4
  • MDG 3 6
  • AAG 3 4
  • 3 End Of The Mid1 Gene, Localized 68 Kb Upstream The Humanzeta Globin Gene On 16p 3
  • CRA36.1 (3-Methyl-Adenine DNA Glycosylase) 3
  • N-Methylpurine-DNA Glycosylase, MPG 3
  • Proliferation-Inducing Protein 11 3
  • Proliferation-Inducing Protein 16 3
  • DNA-3-Methyladenine Glycosylase 3
  • Alkyladenine DNA Glycosylase 2
  • EC 4
  • CRA36.1 3
  • PIG11 3
  • PIG16 3
  • APNG 3

External Ids for MPG Gene

Previous GeneCards Identifiers for MPG Gene

  • GC16P000148
  • GC16P000067
  • GC16P000069
  • GC16P000068
  • GC16P000127
  • GC16P000046

Summaries for MPG Gene

GeneCards Summary for MPG Gene

MPG (N-Methylpurine-DNA Glycosylase) is a Protein Coding gene. Diseases associated with MPG include familial colorectal cancer. Among its related pathways are DNA Repair and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include damaged DNA binding and DNA-7-methylguanine glycosylase activity.

UniProtKB/Swiss-Prot for MPG Gene

  • Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions

Gene Wiki entry for MPG Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPG Gene

Genomics for MPG Gene

Regulatory Elements for MPG Gene

Transcription factor binding sites by QIAGEN in the MPG gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MPG Gene

77,007 bp from pter
85,853 bp from pter
8,847 bases
Plus strand

Genomic View for MPG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPG Gene

Proteins for MPG Gene

  • Protein details for MPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DNA-3-methyladenine glycosylase
    Protein Accession:
    Secondary Accessions:
    • G5E9E2
    • Q13770
    • Q15275
    • Q15961
    • Q5J9I4
    • Q96BZ6
    • Q96S33
    • Q9NNX5

    Protein attributes for MPG Gene

    298 amino acids
    Molecular mass:
    32869 Da
    Quaternary structure:
    • Binds MBD1. Binds SSBP1

    Three dimensional structures from OCA and Proteopedia for MPG Gene

    Alternative splice isoforms for MPG Gene


neXtProt entry for MPG Gene

Proteomics data for MPG Gene at MOPED

Post-translational modifications for MPG Gene

  • Ubiquitination at Lys80 and Lys229
  • Modification sites at PhosphoSitePlus

Other Protein References for MPG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MPG Gene

Domains for MPG Gene

Gene Families for MPG Gene

Protein Domains for MPG Gene

Suggested Antigen Peptide Sequences for MPG Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DNA glycosylase MPG family.
  • Belongs to the DNA glycosylase MPG family.
genes like me logo Genes that share domains with MPG: view

Function for MPG Gene

Molecular function for MPG Gene

GENATLAS Biochemistry:
DNA glycosylase,3-methyl-adenine,base excision repair
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine
UniProtKB/Swiss-Prot EnzymeRegulation:
Binding to SSBP1 in mitochondria inhibits glycosylase activity in the context of a single-stranded DNA (ssDNA), but not a double-stranded DNA (dsDNA) substrates.
UniProtKB/Swiss-Prot Function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions

Enzyme Numbers (IUBMB) for MPG Gene

Gene Ontology (GO) - Molecular Function for MPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003684 damaged DNA binding TAS 10854423
GO:0003824 catalytic activity --
GO:0003905 alkylbase DNA N-glycosylase activity IBA --
GO:0005515 protein binding IPI 18482256
genes like me logo Genes that share ontologies with MPG: view
genes like me logo Genes that share phenotypes with MPG: view

Animal Models for MPG Gene

MGI Knock Outs for MPG:

Animal Model Products

miRNA for MPG Gene

miRTarBase miRNAs that target MPG

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPG

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MPG Gene

Localization for MPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPG Gene

Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid. Nucleus.

Subcellular locations from

Jensen Localization Image for MPG Gene COMPARTMENTS Subcellular localization image for MPG gene
Compartment Confidence
nucleus 4
chloroplast 2
cytoskeleton 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0042645 mitochondrial nucleoid IEA --
genes like me logo Genes that share ontologies with MPG: view

Pathways for MPG Gene

genes like me logo Genes that share pathways with MPG: view

PCR Array Products

Gene Ontology (GO) - Biological Process for MPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006284 base-excision repair TAS --
GO:0006285 base-excision repair, AP site formation TAS --
GO:0006307 DNA dealkylation involved in DNA repair TAS 1645538
GO:0045007 depurination TAS --
genes like me logo Genes that share ontologies with MPG: view

Drugs for MPG Gene

(5) HMDB Compounds for MPG Gene

Compound Synonyms Cas Number PubMed IDs
  • 3-Methyl-3H-Purin-6-amine
  • 3-Methyl-Guanine (VAN) (8CI)
  • 6-Amino-7-methylpurine
  • 2-Amino-1,7-dihydroxy-7-methyl-6H-purine-6-one
  • Apo-Loperamide

(35) Novoseek inferred chemical compound relationships for MPG Gene

Compound -log(P) Hits PubMed IDs
1,n6-ethenoadenine 97.4 20
3-methyladenine 96.5 69
3-methylguanine 94.5 5
7-methylguanine 93.2 13
apng 92.3 12
genes like me logo Genes that share compounds with MPG: view

Transcripts for MPG Gene

Unigene Clusters for MPG Gene

N-methylpurine-DNA glycosylase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPG Gene

No ASD Table

Relevant External Links for MPG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPG Gene

mRNA expression in normal human tissues for MPG Gene

Protein differential expression in normal tissues for MPG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.3), Blymphocyte (7.0), and Lymph node (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPG Gene

SOURCE GeneReport for Unigene cluster for MPG Gene Hs.459596

genes like me logo Genes that share expressions with MPG: view

Expression partners for MPG Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MPG Gene

Orthologs for MPG Gene

This gene was present in the common ancestor of chordates.

Orthologs for MPG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MPG 35
  • 80.75 (n)
  • 78.7 (a)
MPG 36
  • 74 (a)
(Canis familiaris)
Mammalia MPG 35
  • 82.73 (n)
  • 82.01 (a)
MPG 36
  • 80 (a)
(Mus musculus)
Mammalia Mpg 35
  • 79.36 (n)
  • 81.15 (a)
Mpg 16
Mpg 36
  • 63 (a)
(Rattus norvegicus)
Mammalia Mpg 35
  • 77.08 (n)
  • 78.07 (a)
(Monodelphis domestica)
Mammalia MPG 36
  • 65 (a)
(Pan troglodytes)
Mammalia MPG 36
  • 82 (a)
(Gallus gallus)
Aves MPG 35
  • 63.76 (n)
  • 60.17 (a)
MPG 36
  • 53 (a)
(Anolis carolinensis)
Reptilia MPG 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC549932 35
  • 58.52 (n)
  • 60.63 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16168 35
(Danio rerio)
Actinopterygii mpg 35
  • 59.76 (n)
  • 60.98 (a)
mpg 36
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for MPG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPG Gene

Gene Tree for MPG (if available)
Gene Tree for MPG (if available)

Paralogs for MPG Gene

No data available for Paralogs for MPG Gene

Variants for MPG Gene

Sequence variations from dbSNP and Humsavar for MPG Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs534774261 -- 81,135(+) ACTGC(A/G)GTGAG intron-variant
rs534192986 -- 83,138(+) GAAGC(C/T)GCCCA reference, synonymous-codon
rs534166983 -- 83,393(+) GGTTT(C/T)GGGAG intron-variant
rs533848415 -- 82,561(+) CCCTT(G/T)TGGCC intron-variant
rs533827737 -- 82,220(+) CACCA(C/T)CCTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPG Gene

Variant ID Type Subtype PubMed ID
nsv904623 CNV Gain+Loss 21882294
dgv2455n71 CNV Loss 21882294
esv2422427 CNV Duplication 17116639
dgv789e1 CNV Complex 17122850
nsv518291 CNV Loss 19592680
dgv2456n71 CNV Loss 21882294
nsv904628 CNV Loss 21882294
dgv2457n71 CNV Loss 21882294
nsv904631 CNV Loss 21882294
esv32706 CNV Loss 17666407
nsv9317 CNV Gain 18304495
esv26636 CNV Gain+Loss 19812545
nsv820705 CNV Duplication 20802225
esv1240373 CNV Deletion 17803354
esv996836 CNV Insertion 20482838
esv1393228 CNV Insertion 17803354
nsv904634 CNV Loss 21882294

Relevant External Links for MPG Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPG Gene

Disorders for MPG Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MPG Gene in MalaCards »

(1) Disease for MPG Gene

(10) Novoseek inferred disease relationships for MPG Gene

Disease -log(P) Hits PubMed IDs
chromosomal aberrations 20.6 3
cancer lung 5.59 2
inflammation 0 1
glioma 0 1
breast cancer 0 9

Relevant External Links for MPG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MPG: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for MPG Gene

Publications for MPG Gene

  1. Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase. (PMID: 1874728) Chakravarti D. … Mitra S. (J. Biol. Chem. 1991) 2 3 4 23
  2. Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere. (PMID: 8475094) Vickers M.A. … Higgs D.R. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 23
  3. Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse. (PMID: 8318735) Kielman M.F. … Bernini L.F. (Mamm. Genome 1993) 3 4 23
  4. Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16. (PMID: 1924375) Samson L. … Call K. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 23
  5. Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision. (PMID: 9790531) Lau A.Y. … Ellenberger T. (Cell 1998) 3 4 23

Products for MPG Gene

  • Addgene plasmids for MPG

Sources for MPG Gene

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