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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MPG Gene

protein-coding GIFtS: 65
GCID: GC16P000127

N-methylpurine-DNA glycosylase

Explore 25 diseases affiliated with
MPG via

MalaCards

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
N-Methylpurine-DNA Glycosylase¹ ² ³		PIG16²
MDG¹ ² ⁵		Anpg¹
3-Alkyladenine DNA Glycosylase² ³		CRA36.1 (3-Methyl-Adenine DNA Glycosylase)²
3-Methyladenine DNA Glycosidase² ³		DNA-3-Methyladenine Glycosylase²
AAG² ³		N-Methylpurine-DNA Glycosylase, MPG²
ADPG² ³		Proliferation-Inducing Protein 11²
3' End Of The Mid1 Gene, Localized 68 Kb Upstream The Humanzeta Globin Gene On 16p²		Proliferation-Inducing Protein 16²
APNG²		ANPG³
CRA36.1²		EC 3.2.2.21³
Mid1²		MID1³
PIG11²

External Ids:	HGNC: 7211¹	Entrez Gene: 4350²	Ensembl: ENSG00000103152⁷	OMIM: 156565⁵	UniProtKB: P29372³

Export aliases for MPG gene to outside databases

Previous GC identifers: GC16P000148 GC16P000067 GC16P000069 GC16P000068 GC16P000046

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: 3MG_HUMAN, P29372

Function: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the

damaged DNA polymer formed by alkylation lesions

Gene Wiki entry for MPG

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MPG gene promoter:
STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MPG promoter sequence

Search SABiosciences Chromatin IP Primers for MPG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

MPG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPG gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P000127: view genomic region (about GC identifiers)

Start:	127,006 bp from pter	End:	135,852 bp from pter
Size:	8,847 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: 3MG_HUMAN, P29372 (See protein sequence)

Recommended Name: DNA-3-methyladenine glycosylase

Size: 298 amino acids; 32869 Da

Subunit: Binds MBD1

Subcellular location: Nucleus (Potential)

6 PDB 3D structures from and Proteopedia for MPG:

1BNK (3D)

1EWN (3D)

1F4R (3D)

1F6O (3D)

3QI5 (3D)

3UBY (3D)

Secondary accessions: Q13770 Q15275 Q15961 Q96BZ6 Q96S33 Q9NNX5

Alternative splicing: 2 isoforms: P29372-1 P29372-2

Explore the universe of human proteins at neXtProt for MPG: NX_P29372

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P29372

MPG Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001015052.1 NP_001015054.1 NP_002425.2

ENSEMBL proteins:

ENSP00000388097 ENSP00000348809 ENSP00000219431 ENSP00000380918

Reactome Protein details: P29372
Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for MPG
	Uscn Proteins for MPG

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--

MPG for ontologies About GeneDecksing

MPG Antibody Products:

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Assay Products for MPG:

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	Uscn ELISAs and CLIAs for MPG

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MPG for domains About GeneDecksing

2 InterPro domains/families:

IPR011034 Formyl_transferase_C-like

IPR003180 PurDNA_glycsylse

Graphical View of Domain Structure for InterPro Entry P29372

ProtoNet protein and cluster: P29372

1 Blocks protein family: IPB003180 Methylpurine-DNA glycosylase (MPG)

UniProtKB/Swiss-Prot: 3MG_HUMAN, P29372

Similarity: Belongs to the DNA glycosylase MPG family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: 3MG_HUMAN, P29372

Function: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the

damaged DNA polymer formed by alkylation lesions

Catalytic activity: Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and

7-methyladenine

Genatlas biochemistry entry for MPG:

DNA glycosylase,3-methyl-adenine,base excision repair

Enzyme Number (IUBMB): EC 3.2.2.21¹

miRNA Products:		OriGene 3'-UTR Clone (see all 3): MPG Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPG
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		Browse SwitchGear 3'UTR luciferase reporter plasmids

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPG (see all 7) OriGene shRNA RFP: MPG OriGene siRNA: MPG
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MPG

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MPG
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPG

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003684	damaged DNA binding	TAS	10854423
GO:0003905	alkylbase DNA N-glycosylase activity	--	--
GO:0005515	protein binding	IPI	18482256
GO:0008725	DNA-3-methyladenine glycosylase activity	IEA	--

MPG for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for MPG:

Decreased G3BP1 protein expres

Decreased circadian period len

Decreased influenza A virus in

Animal Models:
Mouse knock-outs for MPG: Mpg^tm1Rhe Mpg^tm1Lds
7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mpg):

adipose tissue	cellular	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism
immune system	tumorigenesis

MPG for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Base-Excision Repair, AP Site Formation

Base-Excision Repair, AP Site Formation	1.00	Depurination	0.38
Displacement of DNA glycosylase by APE1	0.89	Recognition and association of DNA glycosylase with site containing an affected purine	0.38
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway	0.80	Cleavage of the damaged purine	0.38
Resolution of AP sites via the single-nucleotide replacement pathway	0.67

Resolution of Abasic Sites (AP sites)

Base Excision Repair	1.00	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	0.89
Resolution of Abasic Sites (AP sites)	1.00	Base excision repair	0.51
Removal of DNA patch containing abasic residue	0.89

Busulfan Pathway, Pharmacodynamics

Busulfan Pathway, Pharmacodynamics

1.00

Nucleotide Excision Repair

DNA Repair

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

5/12 Reactome Pathways for MPG (see all 12)

	Removal of DNA patch containing abasic residue
	DNA Repair
	Resolution of AP sites via the multiple-nucleotide patch replacement pathway
	Base-Excision Repair, AP Site Formation
	Base Excision Repair

1 PharmGKB Pathway for MPG

Busulfan Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for MPG):

Base excision repair

MPG for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MPG

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/45 Interacting proteins for MPG (P29372^{1, 2, 3} ENSP00000219431⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 45)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRNP	P04156¹^,³	EBI-1043398,EBI-977302 I2D: score=1
XRCC1	P18887²^,³, ENSP00000262887⁴	MINT-7294862 I2D: score=1 STRING: ENSP00000262887
RAD23A	P54725³, ENSP00000321365⁴	I2D: score=2 STRING: ENSP00000321365
CAPZA1	P52907³, ENSP00000263168⁴	I2D: score=1 STRING: ENSP00000263168
MIF	P14174³, ENSP00000215754⁴	I2D: score=1 STRING: ENSP00000215754

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006281	DNA repair	TAS	--
GO:0006284	base-excision repair	TAS	--
GO:0006285	base-excision repair, AP site formation	TAS	--
GO:0006307	DNA dealkylation involved in DNA repair	TAS	1645538
GO:0045007	depurination	TAS	--

MPG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MPG for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MPG

5 HMDB Compounds for MPG About this table

Compound	Synonyms	CAS #	PubMed Ids
3-Methyladenine	3-methyl-3H-Purin-6-amine (see all 5)	5142-23-4	--
3-Methylguanine	N3-Methylguanine (see all 5)	2958-98-7	--
7-Methyladenine	7-Methyl-7H-purin-6-amine (see all 6)	935-69-3	--
7-Methylguanine	2-Amino-6-hydroxy-7-methylpurine (see all 8)	578-76-7	--
Loperamide	Apo-Loperamide (see all 10)	53179-11-6	--

10/35 Novoseek chemical compound relationships for MPG gene (see all 35) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
1,n6-ethenoadenine	97.4	29	1409645 (2), 10891085 (2), 12202763 (1), 10626225 (1) (see all 18)
3-methyladenine	96.5	99	9895121 (5), 8475094 (4), 15651853 (4), 8435858 (4) (see all 44)
3-methylguanine	94.5	7	1874728 (1), 14729667 (1), 7528899 (1), 8435858 (1) (see all 5)
7-methylguanine	93.2	19	9813117 (2), 15651853 (2), 1874728 (1), 19219989 (1) (see all 11)
apng	92.3	13	12202763 (4), 16290249 (3), 10626224 (2), 9837917 (2) (see all 5)
hypoxanthine	83	69	17716976 (5), 19219989 (3), 17655363 (3), 19449863 (2) (see all 21)
3,n(4)-ethenocytosine	77.8	1	14761949 (1)
o6-methylguanine	74.9	3	11410664 (1), 18992265 (1), 9103402 (1)
chloroethyl nitrosoureas	74.4	2	7605343 (1), 12663522 (1)
methylmethanesulfonate	74.1	12	1874728 (2), 18992265 (2), 12566303 (2), 16288039 (2) (see all 6)

Search CenterWatch for drugs/clinical trials and news about MPG / 3MG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MPG gene (3 alternative transcripts):

NM_001015052.2 NM_001015054.2 NM_002434.3

Unigene Cluster for MPG:

N-methylpurine-DNA glycosylase

Hs.459596 [show with all ESTs]

Unigene Representative Sequence: BF572325

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000436333 ENST00000356432(uc010bqp.3 uc002cfo.3) ENST00000475280

ENST00000219431(uc002cfn.3) ENST00000397817(uc002cfm.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): MPG Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPG
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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPG (see all 7) OriGene shRNA RFP: MPG OriGene siRNA: MPG
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPG

Additional cDNA sequence:

AK308654.1 AY258284.1 BC014991.1 L10752.1 M71215.1 M74905.1 M99626.1 S51033.1

X56528.1

14 DOTS entries:

DT.100042094 DT.444615 DT.100782934 DT.92446754 DT.95292872 DT.120688508 DT.95092525 DT.120688515

DT.100782930 DT.100782931 DT.101956434 DT.121645427 DT.95226846 DT.95246148

24/263 AceView cDNA sequences (see all 263):

AI754347 AI205596 BM720878 AI669063 CR598824 AW024618 AW593038 CR612592

BQ678708 AI131317 CR606356 N91934 BM854974 CB044049 AI089498 BI906325

AI817691 BQ053339 CA488184 BG479289 BQ888825 BE221981 BQ684616 AW050694

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MPG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGGGGAGTG

About this image

MPG expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Branchial Arch 1

Paraxial Mesoderm Cells

Bone, Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MPG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MPG

SOURCE GeneReport for Unigene cluster: Hs.459596

SABiosciences Expression via Pathway-Focused PCR Arrays including MPG:

DNA Damage Signaling Pathway in human mouse rat

DNA Repair in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPG Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPG

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MPG gene from 7/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mpg^{1 , 5}	N-methylpurine-DNA glycosylase^{1, 5}	80.38(n)¹ 82.31(a)¹		11 (18.83 cM)⁵ 268395¹ NM_010822.3¹ NP_034952.2¹ 32226505⁵
chicken (Gallus gallus)	Aves	MPG¹	N-methylpurine-DNA glycosylase	63.76(n) 60.17(a)		416648 XM_414945.3 XP_414945.3
lizard (Anolis carolinensis)	Reptilia	MPG⁶	--	59(a)	1 ↔ 1	AAWZ02037681(14519-15066)
African clawed frog (Xenopus laevis)	Amphibia	Xl.16168²	Xenopus laevis transcribed sequence with weak similarity more	71.09(n)		BJ045678.1
zebrafish (Danio rerio)	Actinopterygii	mpg¹	N-methylpurine-DNA glycosylase	59.11(n) 59.11(a)		566516 NM_001082850.1 NP_001076319.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G12040⁶	DNA-3-methyladenine glycosylase	28(a)	1 ↔ 1	3(3835129-3836833)
rice (Oryza sativa)	Liliopsida	--	DNA-3-methyladenine glycosylase, putative, express...	25(a)	1 ↔ 1	2(32689510-32691716)

ENSEMBL Gene Tree for MPG (if available)
TreeFam Gene Tree for MPG (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs116336405^1,2	F,	--	125019(+)	`GGACGC/TGCACG`	1	--	us2k¹		1		WA	118
rs148446203^1,2		--	125024(+)	`CGCACA/GAAACT`	1	--	us2k¹		0	--	--	--	--
rs184889730^1,2		--	125053(+)	`ACATAA/GACAAG`	1	--	us2k¹		0	--	--	--	--
rs189820664^1,2		--	125054(+)	`CATAGA/CCAAGT`	1	--	us2k¹		0	--	--	--	--
rs75307641^1,2	F,	--	125128(+)	`CCCCTA/GTACGG`	1	--	us2k¹		1		WA	118
rs2562157^1,2	F,	--	125181(+)	`GGAGAA/GATGGA`	1	--	us2k¹ tfbs³		1		WA	118
rs80173207^1,2	C,F,	--	125231(+)	`CAGGCG/ATCTGA`	1	--	us2k¹		3		WA NA EA	358
rs115007213^1,2	F,	--	125285(+)	`GCCCTC/TACACC`	1	--	us2k¹		3		WA NA EA	358
rs2541635^1,2	C,F,A,	--	125342(-)	`GGGTAC/GCTGTT`	1	--	us2k¹		10		NA CSA WA EA	372
rs117247538^1,2	F,	--	125424(+)	`CCTGGG/ACTTTG`	1	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for MPG (127006 - 135852 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for MPG
4 CNVs: 7126 3986 5329 30729
2 Indels: 25675 72390
Human Gene Mutation Database (HGMD): MPG

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MPG for disorders           About GeneDecksing

OMIM gene information: 156565    OMIM disorders: --

20/25 diseases for MPG (see all 25):    About MalaCards

tricuspid valve stenosis graft versus host disease lutembacher's syndrome chronic lymphocytic leukemia

lymphocytic leukemia hepatitis a familial colorectal cancer rheumatoid arthritis

multiple sclerosis ovarian cancer colorectal cancer breast cancer

arthritis meningioma breast carcinoma leukemia

osteosarcoma lung cancer hepatitis carcinoma

10 Novoseek disease relationships for MPG gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
chromosomal aberrations	20.6	3	7528899 (2), 9731510 (1)
cancer lung	5.59	3	10477488 (2)
inflammation	0	1	14679184 (1)
glioma	0	1	17255284 (1)
breast cancer	0	14	9684856 (2), 15299078 (2), 10563836 (2), 12566303 (2) (see all 5)
ovarian cancer	0	2	17200364 (1)
nsclc	0	5	16613673 (2), 10477488 (1)
tumors	0	38	12820404 (8), 11724299 (4), 12014652 (4), 16288039 (2) (see all 10)
carcinoma	0	5	11724299 (2), 12014652 (1), 16288039 (1)
cancer	0	6	16834910 (1), 15299078 (1), 8611396 (1)

Genetic Association Database (GAD): MPG
Human Genome Epidemiology (HuGE) Navigator: MPG (16 documents)

Export disorders for MPG gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MPG gene, integrated from 9 sources (see all 167):
(articles sorted by number of sources associating them with MPG)

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Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase. (PubMed id 1874728)^{1, 2, 3, 9} Chakravarti D.... Mitra S. (1991)
Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin. (PubMed id 14555760)^{1, 2, 9} Watanabe S.... Nakao M. (2003)
Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere. (PubMed id 8475094)^{1, 2, 9} Vickers M.A.... Higgs D.R. (1993)
Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse. (PubMed id 8318735)^{1, 2, 9} Kielman M.... Bernini L.F. (1993)
Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision. (PubMed id 9790531)^{1, 2, 9} Lau A.Y.... Ellenberger T. (1998)
Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16. (PubMed id 1924375)^{1, 2, 9} Samson L.... Call K. (1991)
Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. (PubMed id 16195237)^{1, 4} Zienolddiny S....Haugen A. (2006)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)^{1, 2} Martin J.... Pennacchio L.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)^{1, 2} Daniels R.J....Higgs D.R. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4350	HGNC: 7211	AceView: MPG	Ensembl:ENSG00000103152	euGenes: HUgn4350
ECgene: MPG	Kegg: 4350	H-InvDB: MPG

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MPG	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MPG	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mpg/

Intellectual Property for MPG gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MPG gene:
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GeneCards and IP:
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N-methylpurine-DNA glycosylase

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MPG (Gene Symbol)
N-Methylpurine-DNA Glycosylase
MDG
3-Alkyladenine DNA Glycosylase
3-Methyladenine DNA Glycosidase
AAG
ADPG
3' End Of The Mid1 Gene, Localized 68 Kb Upstream The Humanzeta Globin Gene On 16p
APNG
CRA36.1
Mid1
PIG11
PIG16
Anpg
CRA36.1 (3-Methyl-Adenine DNA Glycosylase)
DNA-3-Methyladenine Glycosylase
N-Methylpurine-DNA Glycosylase, MPG
Proliferation-Inducing Protein 11
Proliferation-Inducing Protein 16
ANPG
EC 3.2.2.21
MID1

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MPG Gene

N-methylpurine-DNA glycosylase

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