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Aliases for MPEG1 Gene

Aliases for MPEG1 Gene

  • Macrophage Expressed 1 2 3 5
  • Macrophage Expressed Gene 1 2 3
  • Macrophage Gene 1 Protein 3 4
  • Mpg-1 3 4
  • Perforin 2 3
  • MPS1 3
  • MPG1 3

External Ids for MPEG1 Gene

Previous GeneCards Identifiers for MPEG1 Gene

  • GC11M059228
  • GC11M058753
  • GC11M058751
  • GC11M058733
  • GC11M058975
  • GC11M055321

Summaries for MPEG1 Gene

GeneCards Summary for MPEG1 Gene

MPEG1 (Macrophage Expressed 1) is a Protein Coding gene. Among its related pathways are Cell cycle.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPEG1 Gene

Genomics for MPEG1 Gene

Regulatory Elements for MPEG1 Gene

Enhancers for MPEG1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MPEG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MPEG1 Gene

59,208,510 bp from pter
59,213,021 bp from pter
4,512 bases
Minus strand

Genomic View for MPEG1 Gene

Genes around MPEG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPEG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPEG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPEG1 Gene

Proteins for MPEG1 Gene

  • Protein details for MPEG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Macrophage-expressed gene 1 protein
    Protein Accession:
    Secondary Accessions:
    • Q2M1T6
    • Q8TEF8

    Protein attributes for MPEG1 Gene

    716 amino acids
    Molecular mass:
    78587 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB84992.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MPEG1 Gene

Proteomics data for MPEG1 Gene at MOPED

Post-translational modifications for MPEG1 Gene

  • Glycosylation at Asn 185, Asn 255, Asn 269, and Asn 375
  • Modification sites at PhosphoSitePlus

Other Protein References for MPEG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for MPEG1

No data available for DME Specific Peptides for MPEG1 Gene

Domains & Families for MPEG1 Gene

Protein Domains for MPEG1 Gene


Suggested Antigen Peptide Sequences for MPEG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MACPF domain.
  • Contains 1 MACPF domain.
genes like me logo Genes that share domains with MPEG1: view

No data available for Gene Families for MPEG1 Gene

Function for MPEG1 Gene

Phenotypes for MPEG1 Gene

GenomeRNAi human phenotypes for MPEG1:
genes like me logo Genes that share phenotypes with MPEG1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPEG1 Gene

Localization for MPEG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPEG1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for MPEG1 Gene COMPARTMENTS Subcellular localization image for MPEG1 gene
Compartment Confidence
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for MPEG1 Gene

Pathways & Interactions for MPEG1 Gene

SuperPathways for MPEG1 Gene

Superpath Contained pathways
1 Cell cycle
genes like me logo Genes that share pathways with MPEG1: view

Pathways by source for MPEG1 Gene

1 BioSystems pathway for MPEG1 Gene

Interacting Proteins for MPEG1 Gene

Gene Ontology (GO) - Biological Process for MPEG1 Gene


No data available for SIGNOR curated interactions for MPEG1 Gene

Drugs & Compounds for MPEG1 Gene

No Compound Related Data Available

Transcripts for MPEG1 Gene

mRNA/cDNA for MPEG1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MPEG1 Gene

Macrophage expressed 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MPEG1 Gene

No ASD Table

Relevant External Links for MPEG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPEG1 Gene

mRNA expression in normal human tissues for MPEG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MPEG1 Gene

This gene is overexpressed in Testis (25.5), Peripheral blood mononuclear cells (25.1), and Monocytes (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MPEG1 Gene

SOURCE GeneReport for Unigene cluster for MPEG1 Gene Hs.744920

mRNA Expression by UniProt/SwissProt for MPEG1 Gene

Tissue specificity: Expressed in macrophages and peripheral blood monocytes.
genes like me logo Genes that share expression patterns with MPEG1: view

Protein tissue co-expression partners for MPEG1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for MPEG1 Gene

Orthologs for MPEG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MPEG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MPEG1 35
  • 81.82 (n)
  • 82.01 (a)
MPEG1 36
  • 41 (a)
(Canis familiaris)
Mammalia MPEG1 35
  • 83.89 (n)
  • 83.33 (a)
MPEG1 36
  • 83 (a)
(Mus musculus)
Mammalia Mpeg1 35
  • 79.34 (n)
  • 76.02 (a)
Mpeg1 16
Mpeg1 36
  • 75 (a)
Pfpl 36
  • 63 (a)
(Pan troglodytes)
Mammalia MPEG1 35
  • 99.58 (n)
  • 99.3 (a)
MPEG1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mpeg1 35
  • 80.15 (n)
  • 76.36 (a)
(Monodelphis domestica)
Mammalia MPEG1 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia MPEG1 36
  • 66 (a)
(Gallus gallus)
Aves MPEG1 35
  • 65.04 (n)
  • 62.13 (a)
MPEG1 36
  • 58 (a)
(Anolis carolinensis)
Reptilia MPEG1 36
  • 56 (a)
(Danio rerio)
Actinopterygii mpeg1 35
  • 54.79 (n)
  • 52.45 (a)
wufb14d06 35
mpeg1 36
  • 48 (a)
MPEG1 (1 of 3) 36
  • 47 (a)
MPEG1 (3 of 3) 36
  • 47 (a)
Species with no ortholog for MPEG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPEG1 Gene

Gene Tree for MPEG1 (if available)
Gene Tree for MPEG1 (if available)

Paralogs for MPEG1 Gene Pseudogenes for MPEG1 Gene

genes like me logo Genes that share paralogs with MPEG1: view

No data available for Paralogs for MPEG1 Gene

Variants for MPEG1 Gene

Sequence variations from dbSNP and Humsavar for MPEG1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs544864 - 59,211,467(-) GTGTG(A/G)CCAGC reference, missense
rs7926933 - 59,211,211(+) GAGAC(A/G)GTGCC reference, missense
rs17153442 - 59,210,785(+) AACTC(C/T)GCCTT reference, missense
rs1048696 -- 59,209,161(+) AGAGC(A/G)GGCTC utr-variant-3-prime
rs1048708 -- 59,209,099(+) CTTAA(A/G)AGGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MPEG1 Gene

Variant ID Type Subtype PubMed ID
dgv386e1 CNV Complex 17122850

Variation tolerance for MPEG1 Gene

Residual Variation Intolerance Score: 60.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.89; 83.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MPEG1 Gene

Disorders for MPEG1 Gene

Relevant External Links for MPEG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MPEG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPEG1 Gene

Publications for MPEG1 Gene

  1. Isolation of a novel macrophage-specific gene by differential cDNA analysis. (PMID: 7888681) Spilsbury K. … Takayama Y. (Blood 1995) 2 3 4 67
  2. Inhibition of intracellular bacterial replication in fibroblasts is dependent on the perforin-like protein (perforin-2) encoded by macrophage-expressed gene 1. (PMID: 23257510) McCormack R. … Podack E.R. (J Innate Immun 2013) 2 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. Perforin-2/Mpeg1 and other pore-forming proteins throughout evolution. (PMID: 26307549) McCormack R. … Podack E.R. (J. Leukoc. Biol. 2015) 3
  5. Perforin-2 restricts growth of Chlamydia trachomatis in macrophages. (PMID: 23753625) Fields K.A. … Podack E.R. (Infect. Immun. 2013) 3

Products for MPEG1 Gene

Sources for MPEG1 Gene