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Aliases for MPEG1 Gene

Aliases for MPEG1 Gene

  • Macrophage Expressed 1 2 3
  • Macrophage Expressed Gene 1 2 3
  • Macrophage Gene 1 Protein 3 4
  • Mpg-1 3 4
  • MPG1 3 6
  • Macrophage-Expressed Gene 1 Protein 3
  • Perforin 2 3
  • MPS1 3

External Ids for MPEG1 Gene

Previous GeneCards Identifiers for MPEG1 Gene

  • GC11M059228
  • GC11M058753
  • GC11M058751
  • GC11M058733
  • GC11M058975
  • GC11M055321

Summaries for MPEG1 Gene

GeneCards Summary for MPEG1 Gene

MPEG1 (Macrophage Expressed 1) is a Protein Coding gene. Among its related pathways are Cell cycle.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPEG1 Gene

Genomics for MPEG1 Gene

Regulatory Elements for MPEG1 Gene

Genomic Location for MPEG1 Gene

Start:
59,208,510 bp from pter
End:
59,213,021 bp from pter
Size:
4,512 bases
Orientation:
Minus strand

Genomic View for MPEG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPEG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPEG1 Gene

Proteins for MPEG1 Gene

  • Protein details for MPEG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M385-MPEG1_HUMAN
    Recommended name:
    Macrophage-expressed gene 1 protein
    Protein Accession:
    Q2M385
    Secondary Accessions:
    • Q2M1T6
    • Q8TEF8

    Protein attributes for MPEG1 Gene

    Size:
    716 amino acids
    Molecular mass:
    78587 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84992.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MPEG1 Gene

Proteomics data for MPEG1 Gene at MOPED

Post-translational modifications for MPEG1 Gene

  • Glycosylation at Asn185, Asn255, Asn269, and Asn375
  • Modification sites at PhosphoSitePlus

Other Protein References for MPEG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MPEG1 Gene

Domains for MPEG1 Gene

Protein Domains for MPEG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MPEG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2M385

UniProtKB/Swiss-Prot:

MPEG1_HUMAN :
  • Q2M385
Domain:
  • Contains 1 MACPF domain.
genes like me logo Genes that share domains with MPEG1: view

No data available for Gene Families for MPEG1 Gene

Function for MPEG1 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MPEG1 Gene

Localization for MPEG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPEG1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MPEG1 Gene COMPARTMENTS Subcellular localization image for MPEG1 gene
Compartment Confidence
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MPEG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MPEG1: view

Pathways for MPEG1 Gene

SuperPathways for MPEG1 Gene

Superpath Contained pathways
1 Cell cycle
genes like me logo Genes that share pathways with MPEG1: view

Pathways by source for MPEG1 Gene

1 BioSystems pathway for MPEG1 Gene

Interacting Proteins for MPEG1 Gene

Gene Ontology (GO) - Biological Process for MPEG1 Gene

None

Transcripts for MPEG1 Gene

mRNA/cDNA for MPEG1 Gene

(8) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MPEG1 Gene

Macrophage expressed 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPEG1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MPEG1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPEG1 Gene

No ASD Table

Relevant External Links for MPEG1 Gene

GeneLoc Exon Structure for
MPEG1
ECgene alternative splicing isoforms for
MPEG1

Expression for MPEG1 Gene

mRNA expression in normal human tissues for MPEG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MPEG1 Gene

SOURCE GeneReport for Unigene cluster for MPEG1 Gene Hs.744920

mRNA Expression by UniProt/SwissProt for MPEG1 Gene

Q2M385-MPEG1_HUMAN
Tissue specificity: Expressed in macrophages and peripheral blood monocytes.
genes like me logo Genes that share expressions with MPEG1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MPEG1 Gene

Orthologs for MPEG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MPEG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MPEG1 35
  • 99.58 (n)
  • 99.3 (a)
MPEG1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MPEG1 35
  • 81.82 (n)
  • 82.01 (a)
MPEG1 36
  • 41 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MPEG1 35
  • 83.89 (n)
  • 83.33 (a)
MPEG1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mpeg1 35
  • 79.34 (n)
  • 76.02 (a)
Mpeg1 16
Mpeg1 36
  • 75 (a)
OneToMany
Pfpl 36
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MPEG1 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MPEG1 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mpeg1 35
  • 80.15 (n)
  • 76.36 (a)
chicken
(Gallus gallus)
Aves MPEG1 35
  • 65.04 (n)
  • 62.13 (a)
MPEG1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MPEG1 36
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mpeg1 35
  • 54.79 (n)
  • 52.45 (a)
mpeg1 36
  • 48 (a)
OneToMany
MPEG1 (1 of 3) 36
  • 47 (a)
OneToMany
MPEG1 (3 of 3) 36
  • 47 (a)
OneToMany
wufb14d06 35
Species with no ortholog for MPEG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPEG1 Gene

ENSEMBL:
Gene Tree for MPEG1 (if available)
TreeFam:
Gene Tree for MPEG1 (if available)

Paralogs for MPEG1 Gene

Pseudogenes.org Pseudogenes for MPEG1 Gene

genes like me logo Genes that share paralogs with MPEG1: view

No data available for Paralogs for MPEG1 Gene

Variants for MPEG1 Gene

Sequence variations from dbSNP and Humsavar for MPEG1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3847 -- 59,209,238(-) CACAG(C/T)GTGTG utr-variant-3-prime
rs544864 - 59,211,467(-) GTGTG(A/G)CCAGC missense, reference
rs1048696 -- 59,209,161(+) AGAGC(A/G)GGCTC utr-variant-3-prime
rs1048708 -- 59,209,099(+) CTTAA(A/G)AGGCA utr-variant-3-prime
rs1938595 -- 59,213,339(-) TGGTC(A/C)TTTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MPEG1 Gene

Variant ID Type Subtype PubMed ID
dgv386e1 CNV Complex 17122850

Relevant External Links for MPEG1 Gene

HapMap Linkage Disequilibrium report
MPEG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPEG1 Gene

Disorders for MPEG1 Gene

No disorders were found for MPEG1 Gene.

No data available for UniProtKB/Swiss-Prot for MPEG1 Gene

Publications for MPEG1 Gene

  1. Isolation of a novel macrophage-specific gene by differential cDNA analysis. (PMID: 7888681) Spilsbury K. … Takayama Y. (Blood 1995) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Inhibition of intracellular bacterial replication in fibroblasts is dependent on the perforin-like protein (perforin-2) encoded by macrophage-expressed gene 1. (PMID: 23257510) McCormack R. … Podack E.R. (J Innate Immun 2013) 2 3
  4. Perforin-2 restricts growth of Chlamydia trachomatis in macrophages. (PMID: 23753625) Fields K.A. … Podack E.R. (Infect. Immun. 2013) 3
  5. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. (PMID: 23898208) Johnson T.P. … Nath A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3

Products for MPEG1 Gene

Sources for MPEG1 Gene

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