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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MPDZ Gene

protein-coding GIFtS: 62
GCID: GC09M013095

multiple PDZ domain protein

Explore 9 diseases affiliated with
MPDZ via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Multiple PDZ Domain Protein¹ ²
MUPP1¹ ² ³ ⁵
Multi-PDZ Domain Protein 1² ³

External Ids:	HGNC: 7208¹	Entrez Gene: 8777²	Ensembl: ENSG00000107186⁷	OMIM: 603785⁵	UniProtKB: O75970³

Export aliases for MPDZ gene to outside databases

Previous GC identifers: GC09M013272 GC09M013086 GC09M013096

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MPDZ_HUMAN, O75970

Function: Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR

signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses

Gene Wiki entry for MPDZ

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008413.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MPDZ gene promoter:
Sox5 p300 FOXD1 MIF-1 CUTL1 E4BP4 GATA-1 S8 Sox9
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for MPDZ

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPDZ

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p23 Ensembl cytogenetic band: 9p23 HGNC cytogenetic band: 9p23

MPDZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPDZ gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M013095: view genomic region (about GC identifiers)

Start:	13,105,703 bp from pter	End:	13,279,589 bp from pter
Size:	173,887 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MPDZ_HUMAN, O75970 (See protein sequence)

Recommended Name: Multiple PDZ domain protein

Size: 2070 amino acids; 221618 Da

Subunit: Interacts with CLDN5, DLG4, GRIN1, F11R/JAM, CLDN1, NG2, CRB1, MPP4 and MPP5 (By similarity). Interacts with

HTR2A, HTR2B, HTR2C, PLEKHA1/TAPP1, PLEKHA2/TAPP2, CXADR, SYNGAP1, CAMK2A and CAMK2B. Interacts with the adenovirus

type 9 E4-ORF1 protein

Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral

membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell

projection, dendrite. Cell junction, tight junction. Cell junction, synapse. Cell junction, synapse, synaptosome.

Note=Associated with membranes. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells.

Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and

colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann

cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at

the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions

depends on CXADR

Sequence caution: Sequence=AAC61870.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAC05409.1;

Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAE06123.1; Type=Erroneous initiation;

Note=Translation N-terminally shortened; Sequence=CAH71900.1; Type=Erroneous gene model prediction;

Sequence=CAI40490.1; Type=Erroneous gene model prediction; Sequence=CAI40491.1; Type=Erroneous gene model prediction;

Sequence=CAI40492.1; Type=Erroneous gene model prediction; Sequence=CAI40494.1; Type=Erroneous gene model prediction;

Sequence=CAI40495.1; Type=Erroneous gene model prediction; Sequence=CAI41236.1; Type=Erroneous gene model prediction;

Sequence=CAI41237.1; Type=Erroneous gene model prediction; Sequence=CAI41238.1; Type=Erroneous gene model prediction;

Sequence=CAI41240.1; Type=Erroneous gene model prediction; Sequence=CAI56786.1; Type=Miscellaneous discrepancy;

Note=Aberrant splicing;

6/9 PDB 3D structures from and Proteopedia for MPDZ (see all 9):

2FCF (3D)

2FNE (3D)

2IWN (3D)

2IWO (3D)

2IWP (3D)

2IWQ (3D)

Secondary accessions: A6NLC2 B2RTS3 O43798 Q4LE30 Q5CZ80 Q5JTX3 Q5JTX6 Q5JTX7 Q5JUC3 Q5JUC4 Q5VZ62

Q8N790

Alternative splicing: 3 isoforms: O75970-1 O75970-2 O75970-3

Explore the universe of human proteins at neXtProt for MPDZ: NX_O75970

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75970

MPDZ Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001248335.1 NP_001248336.1 NP_003820.2

ENSEMBL proteins:

ENSP00000320006 ENSP00000439807 ENSP00000415964 ENSP00000444230 ENSP00000444717

ENSP00000444151 ENSP00000415208 ENSP00000437651 ENSP00000446358 ENSP00000406902

ENSP00000446298 ENSP00000389705 ENSP00000443672 ENSP00000441111 ENSP00000370410

ENSP00000370403 ENSP00000445259

Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for MPDZ
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MPDZ

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	15364909
GO:0005923	tight junction	IEA	--
GO:0014069	postsynaptic density	IEA	--
GO:0016324	apical plasma membrane	IEA	--
GO:0016327	apicolateral plasma membrane	IDA	15364909

MPDZ for ontologies About GeneDecksing

MPDZ Antibody Products:

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	GenScript Custom Superior Antibodies Services for MPDZ
	Novus Biologicals MPDZ Antibodies
	Search for Antibodies for MPDZ at Abcam
	Uscn Antibodies for MPDZ
	Search ThermoFisher Antibodies for MPDZ

Assay Products for MPDZ:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MPDZ
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MPDZ

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MPDZ for domains About GeneDecksing

3 InterPro domains/families:

IPR015132 L27_2

IPR001478 PDZ

IPR004172 L27

Graphical View of Domain Structure for InterPro Entry O75970

ProtoNet protein and cluster: O75970

1 Blocks protein family: IPB001478 PDZ/DHR/GLGF domain

UniProtKB/Swiss-Prot: MPDZ_HUMAN, O75970

Domain: The PDZ domain 1 binds NG2. The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 9 binds

F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT and the C-terminal PDZ-binding motif of HTR2C. The PDZ

domain 13 binds CXADR (By similarity). The PDZ domain 2 binds CAMK2A and CAMK2B. The PDZ domains 10 and 13 bind

PLEKHA1 and PLEKHA2. The PDZ domain 13 binds SYNGAP1

Similarity: Contains 1 L27 domain

Similarity: Contains 13 PDZ (DHR) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MPDZ_HUMAN, O75970

Function: Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR

signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses

miRNA Products:		OriGene 3'-UTR Clone: MPDZ Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPDZ
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate MPDZ (see all 20):
		hsa-miR-3164 hsa-miR-520d-5p hsa-miR-106a hsa-miR-93 hsa-miR-526b* hsa-miR-3941 hsa-miR-3182 hsa-miR-17

		SwitchGear 3'UTR luciferase reporter plasmid: MPDZ 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPDZ (see all 7) OriGene shRNA RFP: MPDZ OriGene siRNA: MPDZ
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPDZ

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MPDZ

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		GenScript: all cDNA clones in your preferred vector: MPDZ (NM_003829)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MPDZ
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPDZ

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MPDZ
		Search LifeMap BioReagents cell lines for MPDZ

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPDZ

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15364909
GO:0008022	protein C-terminus binding	IPI	11802782

MPDZ for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MPDZ:

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion Tight junctions

Cell adhesion Tight junctions

1.00

Cell adhesion_Tight junctions

0.99

Tight junction

Tight junction

1.00

Signaling events mediated by Stem cell factor receptor (c-Kit)

Kit Receptor Signaling Pathway

0.37

Sertoli-Sertoli Cell Junction Dynamics

Epithelial Tight Junctions

0.36

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for MPDZ

Cell adhesion Tight junctions

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MPDZ

Epithelial Tight Junctions

1 GeneGo (Thomson Reuters) Pathway for MPDZ

Cell adhesion Tight junctions

1 BioSystems Pathway for MPDZ

Kit Receptor Signaling Pathway

1 Kegg Pathway (Kegg details for MPDZ):

Tight junction

MPDZ for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MPDZ

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/129 Interacting proteins for MPDZ (O75970^{2, 3} ENSP00000370410⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 129)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
OR2AG1	Q9H205²^,³, ENSP00000307447⁴	MINT-7289933 MINT-7290250 MINT-7289999 MINT-7289954 MINT-7290110 MINT-7289978 MINT-7290063 MINT-7290305 I2D: score=1 STRING: ENSP00000307447
PLEKHA1	Q9HB21²^,³, ENSP00000357986⁴	MINT-1773801 MINT-1773642 MINT-1773697 MINT-1773820 MINT-65962 MINT-1773562 MINT-1773724 I2D: score=3 STRING: ENSP00000357986
HTR2C	P28335²^,³, ENSP00000276198⁴	MINT-73153 MINT-73189 I2D: score=4 STRING: ENSP00000276198
OR3A1	P47881²^,³, ENSP00000313803⁴	MINT-7290219 I2D: score=1 STRING: ENSP00000313803
SSTR3	P32745²^,³, ENSP00000330138⁴	MINT-6800756 MINT-6800770 MINT-6800562 MINT-6800607 MINT-6801122 I2D: score=1 STRING: ENSP00000330138

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--
GO:0019048	virus-host interaction	IEA	--
GO:0042552	myelination	IEA	--
GO:0044419	interspecies interaction between organisms	--	--

MPDZ for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MPDZ
Search CenterWatch for drugs/clinical trials and news about MPDZ

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MPDZ gene (3 alternative transcripts):

NM_001261406.1 NM_001261407.1 NM_003829.4

Unigene Cluster for MPDZ:

Multiple PDZ domain protein

Hs.169378 [show with all ESTs]

Unigene Representative Sequence: NM_003829

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000319217(uc003zky.4 uc010mib.3 uc010mhx.3 uc011lmm.2 uc003zkz.4 uc010mhy.3 uc010mhz.3 uc011lmn.2 uc010mia.1 uc003zlb.4)

ENST00000381017(uc003zkx.4) ENST00000541718 ENST00000539508 ENST00000438511

ENST00000319198 ENST00000545857 ENST00000538841 ENST00000536827 ENST00000447879

ENST00000542806 ENST00000546205 ENST00000437441 ENST00000535169 ENST00000540202

ENST00000433359 ENST00000542239 ENST00000494251

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MPDZ
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate MPDZ (see all 20):
		hsa-miR-3164 hsa-miR-520d-5p hsa-miR-106a hsa-miR-93 hsa-miR-526b* hsa-miR-3941 hsa-miR-3182 hsa-miR-17

		SwitchGear 3'UTR luciferase reporter plasmid: MPDZ 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPDZ (see all 7) OriGene shRNA RFP: MPDZ OriGene siRNA: MPDZ
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPDZ

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		GenScript: all cDNA clones in your preferred vector: MPDZ (NM_003829)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPDZ
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPDZ

Additional cDNA sequence:

AB210041.1 AJ001319.1 AK058011.1 AK074721.1 AK091945.1 AK098775.1 AK294823.1 AK294976.1

AK307924.1 AK307988.1 AK316489.1 BC140793.1 BC144564.1

12 DOTS entries:

DT.100783776 DT.100783775 DT.454664 DT.92430721 DT.95162657 DT.97841187 DT.97781585 DT.100882918

DT.121165928 DT.426392 DT.99938236 DT.92430716

24/145 AceView cDNA sequences (see all 145):

AI750090 AW088844 AK091945 BQ876382 AA450258 AA983518 NM_003829 AF093419

AW160606 AW163661 AA132116 F08545 AA127886 T31442 AW161163 Z44852

AI055851 BX492831 BF445592 AL694097 CD243744 AX747271 BX415479 BQ214757

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for MPDZ (see all 15) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20a	·	20b	^	21a	·	21b	^	22a	·	22b	^
SP1:																																									-								-		-
SP2:																																									-								-		-
SP3:																																																	-		-
SP4:
SP5:

ExUns:	23a	·	23b	^	24a	·	24b	^	25a	·	25b	^	26	^	27a	·	27b	^	28a	·	28b	^	29a	·	29b	·	29c	·	29d	^	30	^	31	^	32	^	33a	·	33b	·	33c	^	34	^	35a	·	35b	^	36	^	37a	·
SP1:																													-
SP2:																													-
SP3:	-		-		-		-		-		-		-		-		-												-
SP4:
SP5:

ExUns:	37b	^	38	^	39a	·	39b	·	39c	^	40a	·	40b	·	40c	^	41a	·	41b	^	42a	·	42b	^	43	^	44	^	45	^	46	^	47	^	48
SP1:					-						-								-		-
SP2:					-						-						-		-
SP3:					-						-
SP4:			-		-						-
SP5:																	-		-								-

ECgene alternative splicing isoforms for MPDZ

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MPDZ expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTCATTCC

About this image

MPDZ expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MPDZ Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MPDZ

SOURCE GeneReport for Unigene cluster: Hs.169378

UniProtKB/Swiss-Prot: MPDZ_HUMAN, O75970

Tissue specificity: Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas

SABiosciences Expression via Pathway-Focused PCR Array including MPDZ:

Tight Junctions in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPDZ Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPDZ

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPDZ

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MPDZ gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MPDZ¹	multiple PDZ domain protein	73.03(n) 72.5(a)		427360 XM_003643004.1 XP_003643052.1
lizard (Anolis carolinensis)	Reptilia	MPDZ⁶ --	--	70(a) 27(a)	1 ↔ 1 possible ortholog	2(33665424-33776300) 4(100183574-100312687)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1378²	Xenopus laevis transcribed sequence with moderate similarity more	79.69(n)		BJ041435.1
fruit fly (Drosophila melanogaster)	Insecta	dlt³	establishment and/or maintenance of polarity of more	49(a)		62B4 --
worm (Caenorhabditis elegans)	Secernentea	mpz-1⁶	Multiple PDZ domain protein family member (mpz-1)	11(a)	1 → many	II(10738927-10775002)

ENSEMBL Gene Tree for MPDZ (if available)
TreeFam Gene Tree for MPDZ (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MPDZ gene

PARD3B² PDZD2² IL16² INADL² PARD3² LNX2² LNX1²

11 SIMAP similar genes for MPDZ using alignment to 12 protein entries: MPDZ_HUMAN (see all proteins):

SYNJ2BP IL16 DLG4 LIN7C LIN7A SCRIB

TJP2 INADL ARHGAP23 DLG2 GRIP1

MPDZ for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142837436^1,2		--	13105205(+)	`TATCAA/TTTTAC`	3	--	int¹		0	--	--	--	--
rs73404372^1,2	C,	--	13105210(+)	`TTTTAC/TAGATA`	3	--	int¹		2		WA	120
rs73404374^1,2	C,F,	--	13105226(+)	`AATGAG/CAGGGA`	3	--	int¹		3		WA CSA	122
rs192471227^1,2		--	13105301(+)	`CAGTGA/TTCAAG`	3	--	int¹		0	--	--	--	--
rs147428470^1,2		--	13105348(+)	`ATTATG/TATTTT`	3	--	int¹		0	--	--	--	--
rs183428440^1,2		--	13105372(+)	`CACTTG/TAATAG`	3	--	int¹		0	--	--	--	--
rs139204625^1,2		--	13105451(+)	`GGCAGC/GATACT`	3	--	int¹		0	--	--	--	--
rs72706349^1,2	C,	--	13105528(+)	`ATTGTG/AGAGGT`	3	--	int¹		2		NA	122
rs187479350^1,2		--	13105540(+)	`AAAAAC/TATTAA`	3	--	int¹		0	--	--	--	--
rs149865940^1,2		--	13105594(+)	`ATGGAC/TACCAT`	3	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MPDZ (13105703 - 13279589 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MPDZ
2 CNVs: 5261 95850
Human Gene Mutation Database (HGMD): MPDZ

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPDZ

DNA2.0 Custom Variant and Variant Library Synthesis for MPDZ

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MPDZ for disorders           About GeneDecksing

OMIM gene information: 603785    OMIM disorders: --

9 diseases for MPDZ:    About MalaCards

leber congenital amaurosis pharyngitis breast cancer cholesterol

schizophrenia pancreatitis neuronitis alcoholism

choroiditis

1 disease from the University of Copenhagen DISEASES database for MPDZ:

Leber congenital amaurosis

Human Genome Epidemiology (HuGE) Navigator: MPDZ (10 documents)

Export disorders for MPDZ gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MPDZ gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with MPDZ)

Utopia: connect your pdf to the dynamic
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Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain- containing protein MUPP1 in vivo. (PubMed id 11802782)^{1, 2, 9} Kimber W.A....Alessi D.R. (2002)
Cloning and characterization of MUPP1, a novel PDZ domain protein. (PubMed id 9537516)^{1, 2, 9} Ullmer C.... Luebbert H. (1998)
SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. (PubMed id 15312654)^{1, 2, 9} Krapivinsky G.... Clapham D.E. (2004)
Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. (PubMed id 15316081)^{1, 2, 9} van de Pavert S.A.... Wijnholds J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
The coxsackievirus and adenovirus receptor interacts with the multi- PDZ domain protein-1 (MUPP-1) within the tight junction. (PubMed id 15364909)^{1, 2} Coyne C.B.... Bergelson J.M. (2004)
Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. (PubMed id 11150294)^{1, 2} Becamel C.... Ullmer C. (2001)
Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins. (PubMed id 11000240)^{1, 2} Lee S.S.... Javier R.T. (2000)
MUPP1 complexes renal K+ channels to alter cell surfa ce expression and whole cell currents. (PubMed id 19420109)^{1, 9} Sindic A....Miller R.T. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8777	HGNC: 7208	AceView: MPDZ	Ensembl:ENSG00000107186	euGenes: HUgn8777
ECgene: MPDZ	Kegg: 8777	H-InvDB: MPDZ

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MPDZ	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MPDZ gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MPDZ gene:
Search GeneIP for patents involving MPDZ

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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multiple PDZ domain protein

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MPDZ Gene

multiple PDZ domain protein

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