Aliases for MPDZ Gene
External Ids for MPDZ Gene
Previous GeneCards Identifiers for MPDZ Gene
The protein encoded by this gene has multiple PDZ domains, which are hallmarks of protein-protein interactions. The encoded protein is known to interact with the HTR2C receptor and may cause it to clump at the cell surface. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
GeneCards Summary for MPDZ Gene
MPDZ (Multiple PDZ Domain Crumbs Cell Polarity Complex Component) is a Protein Coding gene. Diseases associated with MPDZ include Hydrocephalus, Nonsyndromic, Autosomal Recessive 2 and Congenital Communicating Hydrocephalus. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include protein C-terminus binding. An important paralog of this gene is PATJ.
UniProtKB/Swiss-Prot for MPDZ Gene
Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.