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Aliases for MPC2 Gene

Aliases for MPC2 Gene

  • Mitochondrial Pyruvate Carrier 2 2 3 5
  • Brain Protein 44 2 3 4
  • BRP44 3 4

External Ids for MPC2 Gene

Previous HGNC Symbols for MPC2 Gene

  • BRP44

Summaries for MPC2 Gene

GeneCards Summary for MPC2 Gene

MPC2 (Mitochondrial Pyruvate Carrier 2) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include pyruvate transmembrane transporter activity.

UniProtKB/Swiss-Prot for MPC2 Gene

  • Mediates the uptake of pyruvate into mitochondria.

Gene Wiki entry for MPC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPC2 Gene

Genomics for MPC2 Gene

Regulatory Elements for MPC2 Gene

Promoters for MPC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MPC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MPC2 Gene

Chromosome:
1
Start:
167,916,675 bp from pter
End:
167,937,069 bp from pter
Size:
20,395 bases
Orientation:
Minus strand

Genomic View for MPC2 Gene

Genes around MPC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPC2 Gene

Proteins for MPC2 Gene

  • Protein details for MPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95563-MPC2_HUMAN
    Recommended name:
    Mitochondrial pyruvate carrier 2
    Protein Accession:
    O95563
    Secondary Accessions:
    • A8K261
    • Q3SXR6
    • Q6FIF3

    Protein attributes for MPC2 Gene

    Size:
    127 amino acids
    Molecular mass:
    14279 Da
    Quaternary structure:
    • The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2.

neXtProt entry for MPC2 Gene

Proteomics data for MPC2 Gene at MOPED

Post-translational modifications for MPC2 Gene

  • Ubiquitination at Lys 27
  • Modification sites at PhosphoSitePlus

Other Protein References for MPC2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MPC2 (BRP44)

No data available for DME Specific Peptides for MPC2 Gene

Domains & Families for MPC2 Gene

Protein Domains for MPC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MPC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95563

UniProtKB/Swiss-Prot:

MPC2_HUMAN :
  • Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
Family:
  • Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
genes like me logo Genes that share domains with MPC2: view

No data available for Gene Families for MPC2 Gene

Function for MPC2 Gene

Molecular function for MPC2 Gene

UniProtKB/Swiss-Prot Function:
Mediates the uptake of pyruvate into mitochondria.
genes like me logo Genes that share phenotypes with MPC2: view

Animal Model Products

miRNA for MPC2 Gene

miRTarBase miRNAs that target MPC2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPC2 Gene

Localization for MPC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPC2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MPC2 Gene COMPARTMENTS Subcellular localization image for MPC2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MPC2 Gene

Pathways & Interactions for MPC2 Gene

genes like me logo Genes that share pathways with MPC2: view

Gene Ontology (GO) - Biological Process for MPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006090 pyruvate metabolic process TAS --
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
GO:1902361 mitochondrial pyruvate transmembrane transport IEA --
genes like me logo Genes that share ontologies with MPC2: view

No data available for SIGNOR curated interactions for MPC2 Gene

Drugs & Compounds for MPC2 Gene

No Compound Related Data Available

Transcripts for MPC2 Gene

Unigene Clusters for MPC2 Gene

Mitochondrial pyruvate carrier 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MPC2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: - -
SP3: -
SP4:
SP5: -

Relevant External Links for MPC2 Gene

GeneLoc Exon Structure for
MPC2
ECgene alternative splicing isoforms for
MPC2

Expression for MPC2 Gene

mRNA expression in normal human tissues for MPC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MPC2 Gene

This gene is overexpressed in Nasal epithelium (52.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPC2 Gene



SOURCE GeneReport for Unigene cluster for MPC2 Gene Hs.517768

genes like me logo Genes that share expression patterns with MPC2: view

Protein tissue co-expression partners for MPC2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MPC2 Gene

Orthologs for MPC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MPC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BRP44 35
  • 93.44 (n)
  • 96.06 (a)
MPC2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MPC2 35
  • 92.39 (n)
  • 96.06 (a)
MPC2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mpc2 35
  • 89.33 (n)
  • 93.6 (a)
Mpc2 16
Mpc2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BRP44 35
  • 99.48 (n)
  • 100 (a)
BRP44 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mpc2 35
  • 88.53 (n)
  • 92.8 (a)
oppossum
(Monodelphis domestica)
Mammalia MPC2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MPC2 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRP44 35
  • 76.27 (n)
  • 84.8 (a)
BRP44 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MPC2 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mpc2 35
  • 72.95 (n)
  • 86.07 (a)
Str.6574 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15887 35
zebrafish
(Danio rerio)
Actinopterygii mpc2 35
  • 71.51 (n)
  • 80.34 (a)
wufb22g07 35
mpc2 36
  • 75 (a)
OneToMany
MPC2 (2 of 2) 36
  • 62 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8373 35
fruit fly
(Drosophila melanogaster)
Insecta CG9399 35
  • 56.48 (n)
  • 59.26 (a)
CG32832 36
  • 36 (a)
OneToMany
CG9396 36
  • 41 (a)
OneToMany
CG9399 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F53F10.3 36
  • 46 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL210C 35
  • 50.74 (n)
  • 54.44 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05500g 35
  • 58.78 (n)
  • 50.54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 35 (a)
OneToMany
FMP43 36
  • 34 (a)
OneToMany
MPC3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G22310 35
  • 55.56 (n)
  • 49.02 (a)
rice
(Oryza sativa)
Liliopsida Os07g0449100 35
  • 56.3 (n)
  • 52.22 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03155 35
  • 51.2 (n)
  • 55.67 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC24B11.09 35
  • 57.33 (n)
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1905 36
  • 52 (a)
OneToMany
CSA.932 36
  • 43 (a)
OneToMany
Species with no ortholog for MPC2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPC2 Gene

ENSEMBL:
Gene Tree for MPC2 (if available)
TreeFam:
Gene Tree for MPC2 (if available)

Paralogs for MPC2 Gene

(1) SIMAP similar genes for MPC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MPC2: view

No data available for Paralogs for MPC2 Gene

Variants for MPC2 Gene

Sequence variations from dbSNP and Humsavar for MPC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs9618 -- 167,924,521(-) GTTTT(C/T)TTCTG nc-transcript-variant, reference, synonymous-codon
rs175951 -- 167,925,476(-) TATAT(A/G)TATAT intron-variant
rs203786 -- 167,928,782(-) TATAC(A/T)TCTGC intron-variant
rs203860 -- 167,920,497(-) GATTT(C/T)TGTTT intron-variant
rs203862 -- 167,925,347(-) AACTT(C/T)CCTTT intron-variant

Variation tolerance for MPC2 Gene

Residual Variation Intolerance Score: 49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPC2 Gene

HapMap Linkage Disequilibrium report
MPC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MPC2 Gene

Disorders for MPC2 Gene

Relevant External Links for MPC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MPC2

No disorders were found for MPC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPC2 Gene

Publications for MPC2 Gene

  1. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. (PMID: 22628558) Bricker D.K. … Rutter J. (Science 2012) 2 3 4 67
  2. Structural characterization of a heterogeneous family of rat brain mRNAs. (PMID: 3022128) Tsou A.P. … Sutcliffe J.G. (Mol. Cell. Biol. 1986) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3
  5. A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth. (PMID: 25458841) Schell J.C. … Rutter J. (Mol. Cell 2014) 3

Products for MPC2 Gene

Sources for MPC2 Gene

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