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Aliases for MPC2 Gene

Aliases for MPC2 Gene

  • Mitochondrial Pyruvate Carrier 2 2 3
  • Brain Protein 44 2 3 4
  • BRP44 3 4
  • BRP44, 6

External Ids for MPC2 Gene

Previous HGNC Symbols for MPC2 Gene

  • BRP44

Summaries for MPC2 Gene

GeneCards Summary for MPC2 Gene

MPC2 (Mitochondrial Pyruvate Carrier 2) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include pyruvate transmembrane transporter activity.

UniProtKB/Swiss-Prot for MPC2 Gene

  • Mediates the uptake of pyruvate into mitochondria.

Gene Wiki entry for MPC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPC2 Gene

Genomics for MPC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MPC2 Gene

167,916,675 bp from pter
167,937,069 bp from pter
20,395 bases
Minus strand

Genomic View for MPC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPC2 Gene

No data available for Regulatory Elements for MPC2 Gene

Proteins for MPC2 Gene

  • Protein details for MPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial pyruvate carrier 2
    Protein Accession:
    Secondary Accessions:
    • A8K261
    • Q3SXR6
    • Q6FIF3

    Protein attributes for MPC2 Gene

    127 amino acids
    Molecular mass:
    14279 Da
    Quaternary structure:
    • The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2.

neXtProt entry for MPC2 Gene

Proteomics data for MPC2 Gene at MOPED

Post-translational modifications for MPC2 Gene

  • Ubiquitination at Lys27
  • Modification sites at PhosphoSitePlus

Other Protein References for MPC2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MPC2 Gene

Domains for MPC2 Gene

Protein Domains for MPC2 Gene


Graphical View of Domain Structure for InterPro Entry



  • O95563
  • Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
genes like me logo Genes that share domains with MPC2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MPC2 Gene

Function for MPC2 Gene

Molecular function for MPC2 Gene

UniProtKB/Swiss-Prot Function:
Mediates the uptake of pyruvate into mitochondria.

Gene Ontology (GO) - Molecular Function for MPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050833 pyruvate transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with MPC2: view

Animal Model Products

miRNA for MPC2 Gene

miRTarBase miRNAs that target MPC2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MPC2 Gene

Localization for MPC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPC2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MPC2: view

No data available for Subcellular locations from COMPARTMENTS for MPC2 Gene

Pathways for MPC2 Gene

genes like me logo Genes that share pathways with MPC2: view

Gene Ontology (GO) - Biological Process for MPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006090 pyruvate metabolic process TAS --
GO:0006850 mitochondrial pyruvate transport IEA --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:1901475 pyruvate transmembrane transport IEA --
genes like me logo Genes that share ontologies with MPC2: view

Transcripts for MPC2 Gene

Unigene Clusters for MPC2 Gene

Mitochondrial pyruvate carrier 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MPC2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPC2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: - -
SP3: -
SP5: -

Relevant External Links for MPC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPC2 Gene

mRNA expression in normal human tissues for MPC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MPC2 Gene

This gene is overexpressed in Nasal epithelium (52.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPC2 Gene

SOURCE GeneReport for Unigene cluster for MPC2 Gene Hs.517768

genes like me logo Genes that share expressions with MPC2: view

Expression partners for MPC2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MPC2 Gene

Orthologs for MPC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MPC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BRP44 35
  • 93.44 (n)
  • 96.06 (a)
MPC2 36
  • 96 (a)
(Canis familiaris)
Mammalia MPC2 35
  • 92.39 (n)
  • 96.06 (a)
MPC2 36
  • 96 (a)
(Mus musculus)
Mammalia Mpc2 35
  • 89.33 (n)
  • 93.6 (a)
Mpc2 16
Mpc2 36
  • 92 (a)
(Pan troglodytes)
Mammalia BRP44 35
  • 99.48 (n)
  • 100 (a)
BRP44 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mpc2 35
  • 88.53 (n)
  • 92.8 (a)
(Monodelphis domestica)
Mammalia MPC2 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia MPC2 36
  • 90 (a)
(Gallus gallus)
Aves BRP44 35
  • 76.27 (n)
  • 84.8 (a)
BRP44 36
  • 80 (a)
(Anolis carolinensis)
Reptilia MPC2 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mpc2 35
  • 72.95 (n)
  • 86.07 (a)
Str.6574 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15887 35
(Danio rerio)
Actinopterygii mpc2 35
  • 71.51 (n)
  • 80.34 (a)
wufb22g07 35
mpc2 36
  • 75 (a)
MPC2 (2 of 2) 36
  • 62 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8373 35
fruit fly
(Drosophila melanogaster)
Insecta CG9399 35
  • 56.48 (n)
  • 59.26 (a)
CG32832 36
  • 36 (a)
CG9396 36
  • 41 (a)
CG9399 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea F53F10.3 36
  • 46 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL210C 35
  • 50.74 (n)
  • 54.44 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05500g 35
  • 58.78 (n)
  • 50.54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 35 (a)
FMP43 36
  • 34 (a)
FMP43 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G22310 35
  • 55.56 (n)
  • 49.02 (a)
(Oryza sativa)
Liliopsida Os07g0449100 35
  • 56.3 (n)
  • 52.22 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03155 35
  • 51.2 (n)
  • 55.67 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC24B11.09 35
  • 57.33 (n)
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1905 36
  • 52 (a)
CSA.932 36
  • 43 (a)
Species with no ortholog for MPC2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPC2 Gene

Gene Tree for MPC2 (if available)
Gene Tree for MPC2 (if available)

Paralogs for MPC2 Gene

Selected SIMAP similar genes for MPC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MPC2: view

No data available for Paralogs for MPC2 Gene

Variants for MPC2 Gene

Sequence variations from dbSNP and Humsavar for MPC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9618 -- 167,924,521(-) GTTTT(C/T)TTCTG reference, synonymous-codon, nc-transcript-variant
rs175951 -- 167,925,476(-) TATAT(A/G)TATAT intron-variant
rs203784 -- 167,916,464(+) ggcct(A/C)ccaaa downstream-variant-500B
rs203786 -- 167,928,782(-) TATAC(A/T)TCTGC intron-variant
rs203860 -- 167,920,497(-) GATTT(C/T)TGTTT intron-variant

Relevant External Links for MPC2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MPC2 Gene

Disorders for MPC2 Gene

No disorders were found for MPC2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MPC2 Gene

Publications for MPC2 Gene

  1. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. (PMID: 22628558) Bricker D.K. … Rutter J. (Science 2012) 2 3 4
  2. Structural characterization of a heterogeneous family of rat brain mRNAs. (PMID: 3022128) Tsou A.P. … Sutcliffe J.G. (Mol. Cell. Biol. 1986) 2 3
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for MPC2 Gene

Sources for MPC2 Gene

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