MPC2 Gene
protein-coding GIFtS: 47
GCID: GC01M167886
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|
mitochondrial pyruvate carrier 2(Previous name: brain protein 44 )
(Previous symbol: BRP44)
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Aliases
for MPC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Pyruvate Carrier 21 2 | | Brain Protein 441 2 3 | | BRP441 2 3 | | DKFZP564B1671 |
Export aliases for MPC2 gene to outside databases |
Summaries
for MPC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MPC2_HUMAN, O95563Function: Mediates the uptake of pyruvate into mitochondria
Gene Wiki entry for MPC2 (BRP44)
|
Genomic Views
for MPC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MPC2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MPC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q24 Ensembl cytogenetic band: 1q24.2 HGNC cytogenetic band: 1q24MPC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M167886: view genomic region
(about GC identifiers)
Start:
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167,885,967 bp from pter |
End:
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167,906,278 bp from pter |
Size:
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20,312 bases |
Orientation:
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minus strand |
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Proteins
for MPC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MPC2_HUMAN, O95563 (See
protein sequence)Recommended Name: Mitochondrial pyruvate carrier 2 Size: 127 amino acids; 14279 Da
Subunit: The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2 (By similarity)
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Secondary accessions: A8K261 Q3SXR6 Q6FIF3Explore the universe of human proteins at neXtProt for MPC2: NX_O95563
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95563
MPC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001137146.1 NP_056230.1
ENSEMBL proteins: ENSP00000356820 ENSP00000271373 ENSP00000392874 Reactome Protein details: O95563
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MPC2 for ontologies About GeneDecksing
MPC2 Antibody Products:
Assay Products for MPC2: |
Protein
Domains /
Families
for MPC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MPC2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O95563ProtoNet protein and cluster: O95563 1 Blocks protein family: IPB005336 Protein of unknown function UPF0041
UniProtKB/Swiss-Prot: MPC2_HUMAN, O95563Similarity: Belongs to the mitochondrial pyruvate carrier (MPC) family |
Function
for MPC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MPC2_HUMAN, O95563Function: Mediates the uptake of pyruvate into mitochondria
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPC2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for MPC2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPC2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPC2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0050833 | pyruvate transmembrane transporter activity |
IEA | -- |
MPC2 for ontologies About GeneDecksing
|
Pathways & Interactions
for MPC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Pyruvate metabolism | | | 2 | Metabolism | | | 3 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 4 | TCA Cycle | | | 5 | Glycolysis and gluconeogenesis (short map) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for MPC2
4 
Reactome Pathways for MPC2
MPC2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MPC2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/10 Interacting proteins for MPC2 (O955633 ENSP000002713734) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006090 | pyruvate metabolic process |
IEA | -- | | GO:0006810 | transport |
-- | -- | | GO:0006850 | mitochondrial pyruvate transport |
IEA | -- |
MPC2 for ontologies About GeneDecksing
|
Drugs & Compounds
for MPC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MPC2
Search CenterWatch for drugs/clinical trials and news about MPC2
|
Transcripts
for MPC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MPC2 gene (2 alternative transcripts): NM_001143674.2 NM_015415.3 Unigene Cluster for MPC2: Mitochondrial pyruvate carrier 2 Hs.517768 [show with all ESTs]Unigene Representative Sequence: NR_0265503 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367846(uc001ges.3 uc001geu.3 uc001get.3) ENST00000271373
ENST00000458574(uc009wvn.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPC2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for MPC2 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MPC2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPC2 |
Additional cDNA sequence: AK290126.1 AK307189.1 AK311913.1 AL035304.1 AL110297.1 BC104157.1 BC104158.1 CR407632.1 CR533473.1 NR_026550.2 10 DOTS entries: DT.100858317 DT.100031207 DT.446630 DT.101967633 DT.95219522 DT.95219503 DT.91754081 DT.97847103 DT.95219521 DT.99996202 24/314 AceView cDNA sequences (see all 314): CA943928 BM264143 AW139323 CA307748 CD676509 CA941619 CA313892 BM806480 AI291297 CR533473 BU682646 AL554033 BM664819 BU624506 BM703354 BE122712 AW197038 CA428094 CA950150 CR594136 AL110297 BE969690 BU627184 BU902466
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MPC2 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d |
|---|
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| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for MPC2
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Expression
for MPC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See MPC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MPC2
SOURCE GeneReport for Unigene cluster: Hs.517768
SABiosciences Custom PCR Arrays for MPC2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPC2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MPC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPC2 |
Orthologs
for MPC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MPC2 gene from 10/27 species (see all 27) About this table
ENSEMBL Gene Tree for MPC2 (if available)
TreeFam Gene Tree for MPC2 (if available) |
Paralogs
for MPC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MPC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MPC2 (167885967 - 167906278 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MPC2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPC2 |
|
Disorders
/ Diseases
for MPC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MPC2 for disorders About GeneDecksing
OMIM gene information: 614737
OMIM disorders: --
5  diseases for MPC2: About MalaCardsessential hypertension hypertension t-cell leukemia malaria
leukemia
Export disorders for MPC2 gene to outside databases
|
Publications
for MPC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MPC2 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with MPC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, drosophila, and humans. (PubMed id 22628558)1, 2, 3 Bricker D.K.... Rutter J. (2012)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Structural characterization of a heterogeneous family of rat brain mRNAs. (PubMed id 3022128)1, 3 Tsou A.P....Sutcliffe J.G. (1986)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A QUICK screen for Lrrk2 interaction partners--leucine -rich repeat kinase 2 is involved in actin cytoskeleton dynamics. (PubMed id 20876399)1 Meixner A....Ueffing M. (2011)
- Common variants on 8p12 and 1q24.2 confer risk of schi zophrenia. (PubMed id 22037555)1 Shi Y....He L. (2011)
|
External Searches for MPC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MPC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MPC2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MPC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MPC2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MPC2 gene:
Search GeneIP for patents involving MPC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MPC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MPC2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPC2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPC2 | | | OriGene Protein Over-expression Lysate for MPC2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MPC2 | | OriGene 3'-UTR Clone for MPC2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPC2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPC2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MPC2 | | OriGene Custom Protein Services for MPC2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MPC2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPC2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPC2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPC2 |
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 |  |  |  | |
| | | | Search Tocris compounds for MPC2 |
| |  |  |  |  | | | | |
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 | | | MPC2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPC2 |
|  |  |  | | | | Search ThermoFisher Antibodies for MPC2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPC2 |
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