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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MPC2 Gene

protein-coding   GIFtS: 48
GCID: GC01M167886

Mitochondrial Pyruvate Carrier 2

(Previous name: brain protein 44)
(Previous symbol: BRP44)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mitochondrial Pyruvate Carrier 21 2
Brain Protein 441 2 3
BRP441 2 3

External Ids:    HGNC: 245151   Entrez Gene: 258742   Ensembl: ENSG000001431587   OMIM: 6147375   UniProtKB: O955633   
ORGUL members:         
NONCODE14:n407138      

Export aliases for MPC2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MPC2 Gene: 
MPC2 (mitochondrial pyruvate carrier 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with MPC2 include essential hypertension, and hypertension, and among its related super-pathways are Pyruvate metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include pyruvate transmembrane transporter activity.

UniProtKB/Swiss-Prot: MPC2_HUMAN, O95563
Function: Mediates the uptake of pyruvate into mitochondria

Gene Wiki entry for MPC2 (BRP44) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MPC2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMPC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MPC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24   Ensembl cytogenetic band:  1q24.2   HGNC cytogenetic band: 1q24

MPC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPC2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M167886:  view genomic region     (about GC identifiers)

Start:
167,885,913 bp from pter      End:
167,906,307 bp from pter
Size:
20,395 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MPC2_HUMAN, O95563 (See protein sequence)
Recommended Name: Mitochondrial pyruvate carrier 2  
Size: 127 amino acids; 14279 Da
Subunit: The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2 (By similarity)
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Secondary accessions: A8K261 Q3SXR6 Q6FIF3

Explore the universe of human proteins at neXtProt for MPC2: NX_O95563

Explore proteomics data for MPC2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95563

  • MPC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MPC2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001137146.1  NP_056230.1  

    ENSEMBL proteins: 
     ENSP00000356820   ENSP00000271373   ENSP00000392874  
    Reactome Protein details: O95563
    Human Recombinant Protein Products for MPC2: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral to membrane IEA--

    MPC2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR005336 UPF0041

    Graphical View of Domain Structure for InterPro Entry O95563

    ProtoNet protein and cluster: O95563

    1 Blocks protein domain: IPB005336 Protein of unknown function UPF0041

    UniProtKB/Swiss-Prot: MPC2_HUMAN, O95563
    Similarity: Belongs to the mitochondrial pyruvate carrier (MPC) family


    MPC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPC2_HUMAN, O95563
    Function: Mediates the uptake of pyruvate into mitochondria

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0050833pyruvate transmembrane transporter activity IEA--
         
    MPC2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MPC2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MPC2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Pyruvate metabolism
    Pyruvate metabolism0.60
    Pyruvate metabolism and Citric Acid (TCA) cycle0.49
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport0.72
    3Glycolysis and gluconeogenesis (short map)
    Glycolysis and Gluconeogenesis0.60
    4Metabolism
    Metabolism0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MPC2
        Glycolysis and Gluconeogenesis


    4        Reactome Pathways for MPC2
        Pyruvate metabolism
    Pyruvate metabolism and Citric Acid (TCA) cycle
    Metabolism
    The citric acid (TCA) cycle and respiratory electron transport



    MPC2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MPC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/10 Interacting proteins for MPC2 (O955633 ENSP000002713734) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C20orf24Q9BUV83, ENSP000003412134I2D: score=1 STRING: ENSP00000341213
    SDHBP219123, ENSP000003646494I2D: score=1 STRING: ENSP00000364649
    LRRK2Q5S0073, ENSP000002989104I2D: score=1 STRING: ENSP00000298910
    SEPT7Q161813I2D: score=5 
    EMC2Q150063I2D: score=4 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006090pyruvate metabolic process TAS--
    GO:0006850mitochondrial pyruvate transport IEA--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:1901475pyruvate transmembrane transport ----

    MPC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MPC2

    Search CenterWatch for drugs/clinical trials and news about MPC2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MPC2 gene (2 alternative transcripts): 
    NM_001143674.2  NM_015415.3  

    Unigene Cluster for MPC2:

    Mitochondrial pyruvate carrier 2
    Hs.517768  [show with all ESTs]
    Unigene Representative Sequence: NR_026550
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367846(uc001ges.3 uc001geu.3 uc001get.3) ENST00000271373
    ENST00000458574(uc009wvn.3)
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK290126.1 AK307189.1 AK311913.1 AL035304.1 AL110297.1 BC104157.1 BC104158.1 CR407632.1 
    CR533473.1 NR_026550.2 

    10 DOTS entries:

    DT.100858317  DT.100031207  DT.446630  DT.101967633  DT.95219522  DT.95219503  DT.91754081  DT.97847103 
    DT.95219521  DT.99996202 

    24/314 AceView cDNA sequences (see all 314):

    BM703354 AL035304 AW139323 BM504762 BE122712 AA236527 CA844121 AL554033 
    BQ574830 CR615341 CD676509 BU902466 BQ417273 CA941619 BQ478343 AI291297 
    BU627184 CA313892 AI086059 AI634667 CR533473 BQ287760 AA157009 BU688414 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MPC2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                    -                                                   
    SP2:              -     -                                                   
    SP3:                    -                                                   
    SP4:                                                                        
    SP5:                                            -                           


    ECgene alternative splicing isoforms for MPC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MPC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MPC2 Expression
    About this image


    See MPC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MPC2

    SOURCE GeneReport for Unigene cluster: Hs.517768
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MPC2 gene from 10/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mpc21 , 5 brain protein 445
    mitochondrial pyruvate carrier 21
    89.78(n)1
    94.35(a)1
      1 (72.80 cM)5
    704561  NM_027430.21  NP_081706.11 
     1654610375 
    chicken
    (Gallus gallus)
    Aves BRP441 brain protein 44 77.05(n)
    86.89(a)
      768451  XM_001231386.2  XP_001231387.2 
    lizard
    (Anolis carolinensis)
    Reptilia MPC26
    Uncharacterized protein
    84(a)
    1 ↔ 1
    3(163939192-163953009)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.158872 Xenopus laevis transcribed sequence with moderate similarity more 72.12(n)    CD252878.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb22g072 Danio rerio mRNA similar to DKFZP564B167 protein (cDNA more 73.46(n)    BC049015.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG93991 CG9399 57.01(n)
    59.81(a)
      41157  NM_001170100.1  NP_001163571.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F53F10.31 Protein F53F10.3 57.82(n)
    57.14(a)
      171957  NM_058833.4  NP_491234.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FMP43(YGR243W)4
    FMP431
    Putative protein of unknown function; expression regulated more4
    Fmp43p1
    56.2(n)1
    54.65(a)1
      7(977336-977776)4
    8531581, 4  NP_011759.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G223101 hypothetical protein 55.56(n)
    49.02(a)
      828326  NM_118357.5  NP_193962.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g04491001 hypothetical protein 56.3(n)
    52.22(a)
      4343123  NM_001066081.1  NP_001059546.1 


    ENSEMBL Gene Tree for MPC2 (if available)
    TreeFam Gene Tree for MPC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MPC2 gene
    1 SIMAP similar gene for MPC2 using alignment to 2 protein entries:     MPC2_HUMAN (see all proteins):
    MPC1

    MPC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/349 SNPs in MPC2 are shown (see all 349)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38340681,2
    C,F--167885466(+) GAGATG/-GGAGT 3 -- ds50013Minor allele frequency- -:0.50NA 6
    rs1431881631,2
    --167885479(+) TGCTCC/TTGTCG 3 -- ds50010--------
    rs1475021911,2
    --167885483(+) CTTGTC/TGCCCA 3 -- ds50010--------
    rs115784251,2
    C,F,H--167885545(+) GTTGAA/CGTGAT 3 -- ds50016Minor allele frequency- C:0.42NA WA 12
    rs2002790961,2
    --167885618(+) TTTTG-/TATTATTA 3 -- ds50010--------
    rs115802021,2
    C,F,H--167885634(+) GAGACG/AGGGTT 3 -- ds50014Minor allele frequency- A:0.38NA WA 8
    rs1474164671,2
    C--167885664(+) GGTCTC/TGAACT 3 -- ds50010--------
    rs2037841,2
    F--167885702(+) ggcctC/Accaaa 3 -- ds50012Minor allele frequency- A:0.00NA 4
    rs1823074621,2
    --167885713(+) GTGCTC/TGGATT 3 -- ds50010--------
    rs1878875131,2
    --167885734(+) GCCACC/TGCACC 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for MPC2 (167885913 - 167906307 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MPC2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MPC2
    DNA2.0 Custom Variant and Variant Library Synthesis for MPC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614737    OMIM disorders: --

    4 diseases for MPC2:    About MalaCards
    essential hypertension    hypertension    t-cell leukemia    leukemia


    MPC2 for disorders           About GeneDecksing


    Export disorders for MPC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MPC2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with MPC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, drosophila, and humans. (PubMed id 22628558)1, 2, 3 Bricker D.K.... Rutter J. (2012)
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    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    5. Structural characterization of a heterogeneous family of rat brain mRNAs. (PubMed id 3022128)1, 3 Tsou A.P....Sutcliffe J.G. (1986)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25874 HGNC: 24515 AceView: DKFZP564B167 Ensembl:ENSG00000143158 euGenes: HUgn25874
    ECgene: MPC2 H-InvDB: MPC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MPC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MPC2 gene:
    Search GeneIP for patents involving MPC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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