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Aliases for MPC2 Gene

Aliases for MPC2 Gene

  • Mitochondrial Pyruvate Carrier 2 2 3
  • Brain Protein 44 2 3 4
  • BRP44 3 4
  • BRP44, 6

External Ids for MPC2 Gene

Previous Symbols for MPC2 Gene

  • BRP44

Summaries for MPC2 Gene

GeneCards Summary for MPC2 Gene

MPC2 (Mitochondrial Pyruvate Carrier 2) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include pyruvate transmembrane transporter activity.

UniProtKB/Swiss-Prot for MPC2 Gene

  • Mediates the uptake of pyruvate into mitochondria.

Gene Wiki entry for MPC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPC2 Gene

Genomics for MPC2 Gene

Genomic Location for MPC2 Gene

Start:
167,916,675 bp from pter
End:
167,937,069 bp from pter
Size:
20,395 bases
Orientation:
Minus strand

Genomic View for MPC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPC2 Gene

No data available for Regulatory Elements for MPC2 Gene

Proteins for MPC2 Gene

  • Protein details for MPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95563-MPC2_HUMAN
    Recommended name:
    Mitochondrial pyruvate carrier 2
    Protein Accession:
    O95563
    Secondary Accessions:
    • A8K261
    • Q3SXR6
    • Q6FIF3

    Protein attributes for MPC2 Gene

    Size:
    127 amino acids
    Molecular mass:
    14279 Da
    Quaternary structure:
    • The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2.

neXtProt entry for MPC2 Gene

Proteomics data for MPC2 Gene at MOPED

Post-translational modifications for MPC2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys27

Other Protein References for MPC2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MPC2 Gene

Domains for MPC2 Gene

Protein Domains for MPC2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

MPC2_HUMAN
Family:
  • Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.:
    • O95563
genes like me logo Genes that share domains with MPC2: view

No data available for Gene Families for MPC2 Gene

Function for MPC2 Gene

Molecular function for MPC2 Gene

UniProtKB/Swiss-Prot Function: Mediates the uptake of pyruvate into mitochondria.

Gene Ontology (GO) - Molecular Function for MPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050833 pyruvate transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with MPC2: view

miRNA for MPC2 Gene

miRTarBase miRNAs that target MPC2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MPC2 Gene

Localization for MPC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPC2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MPC2: view

Pathways for MPC2 Gene

genes like me logo Genes that share pathways with MPC2: view

Gene Ontology (GO) - Biological Process for MPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006090 pyruvate metabolic process TAS --
GO:0006850 mitochondrial pyruvate transport IEA --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:1901475 pyruvate transmembrane transport IEA --
genes like me logo Genes that share ontologies with MPC2: view

Transcripts for MPC2 Gene

Unigene Clusters for MPC2 Gene

Mitochondrial pyruvate carrier 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MPC2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: - -
SP3: -
SP4:
SP5: -

Relevant External Links for MPC2 Gene

GeneLoc Exon Structure for
MPC2
ECgene alternative splicing isoforms for
MPC2

Expression for MPC2 Gene

mRNA expression in normal human tissues for MPC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MPC2 Gene

SOURCE GeneReport for Unigene cluster for MPC2 Gene Hs.517768

genes like me logo Genes that share expressions with MPC2: view

Orthologs for MPC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MPC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRP44 36
  • 99.48 (n)
  • 100 (a)
BRP44 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BRP44 36
  • 93.44 (n)
  • 96.06 (a)
MPC2 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MPC2 36
  • 92.39 (n)
  • 96.06 (a)
MPC2 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mpc2 36
  • 89.33 (n)
  • 93.6 (a)
Mpc2 16
Mpc2 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MPC2 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MPC2 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mpc2 36
  • 88.53 (n)
  • 92.8 (a)
chicken
(Gallus gallus)
Aves BRP44 36
  • 76.27 (n)
  • 84.8 (a)
BRP44 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MPC2 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15887 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mpc2 36
  • 72.95 (n)
  • 86.07 (a)
Str.6574 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8373 36
zebrafish
(Danio rerio)
Actinopterygii mpc2 36
  • 71.51 (n)
  • 80.34 (a)
mpc2 37
  • 75 (a)
OneToMany
MPC2 (2 of 2) 37
  • 62 (a)
OneToMany
wufb22g07 36
fruit fly
(Drosophila melanogaster)
Insecta CG32832 37
  • 36 (a)
OneToMany
CG9396 37
  • 41 (a)
OneToMany
CG9399 36
  • 56.48 (n)
  • 59.26 (a)
CG9399 37
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F53F10.3 37
  • 46 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL210C 36
  • 50.74 (n)
  • 54.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 35 (a)
OneToMany
FMP43 37
  • 34 (a)
OneToMany
FMP43 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05500g 36
  • 58.78 (n)
  • 50.54 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G22310 36
  • 55.56 (n)
  • 49.02 (a)
rice
(Oryza sativa)
Liliopsida Os07g0449100 36
  • 56.3 (n)
  • 52.22 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03155 36
  • 51.2 (n)
  • 55.67 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC24B11.09 36
  • 57.33 (n)
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1905 37
  • 52 (a)
OneToMany
CSA.932 37
  • 43 (a)
OneToMany
Species with no ortholog for MPC2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPC2 Gene

ENSEMBL:
Gene Tree for MPC2 (if available)
TreeFam:
Gene Tree for MPC2 (if available)

Paralogs for MPC2 Gene

Selected SIMAP similar genes for MPC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MPC2: view

No data available for Paralogs for MPC2 Gene

Variants for MPC2 Gene

Sequence variations from dbSNP and Humsavar for MPC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2420 -- 167,917,264(-) GGACA(A/T)AAGTA utr-variant-3-prime, nc-transcript-variant
rs9618 -- 167,924,521(-) GTTTT(C/T)TTCTG reference, synonymous-codon, nc-transcript-variant
rs175951 -- 167,925,476(-) TATAT(A/G)TATAT intron-variant
rs203784 -- 167,916,464(+) ggcct(A/C)ccaaa downstream-variant-500B
rs203786 -- 167,928,782(-) TATAC(A/T)TCTGC intron-variant

Relevant External Links for MPC2 Gene

HapMap Linkage Disequilibrium report
MPC2

No data available for Structural Variations from Database of Genomic Variants (DGV) for MPC2 Gene

Disorders for MPC2 Gene

No disorders were found for MPC2 Gene.

No data available for UniProtKB/Swiss-Prot for MPC2 Gene

Publications for MPC2 Gene

  1. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. (PMID: 22628558) Bricker D.K. … Rutter J. (Science 2012) 2 3 4
  2. Structural characterization of a heterogeneous family of rat brain mRNAs. (PMID: 3022128) Tsou A.P. … Sutcliffe J.G. (Mol. Cell. Biol. 1986) 2 3
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for MPC2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MPC2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MPC2
    • Block miRNA regulation of MPC2 using miScript Target Protectors

    Sources for MPC2 Gene

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