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Aliases for MPC2 Gene

Aliases for MPC2 Gene

  • Mitochondrial Pyruvate Carrier 2 2 3 5
  • Brain Protein 44 2 3 4
  • BRP44 3 4

External Ids for MPC2 Gene

Previous HGNC Symbols for MPC2 Gene

  • BRP44

Summaries for MPC2 Gene

GeneCards Summary for MPC2 Gene

MPC2 (Mitochondrial Pyruvate Carrier 2) is a Protein Coding gene. Among its related pathways are Metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. GO annotations related to this gene include pyruvate transmembrane transporter activity.

UniProtKB/Swiss-Prot for MPC2 Gene

  • Mediates the uptake of pyruvate into mitochondria.

Gene Wiki entry for MPC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPC2 Gene

Genomics for MPC2 Gene

Regulatory Elements for MPC2 Gene

Enhancers for MPC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F167904 0.9 Ensembl ENCODE 20.2 +32.0 31958 1.8 TFAP4 PKNOX1 JUN ZNF316 ZBTB48 SCRT2 SMC3 FOS NFE2 HLF MPC2 DCAF6 ENSG00000250762 ENSG00000232194 ADCY10 GC01P167854
GH01F167910 0.2 Ensembl 20.1 +25.9 25868 1.2 CTCF CEBPB TRIM28 MPC2 DCAF6 ENSG00000232194 ENSG00000250762 ADCY10 GC01P167854
GH01F167912 1.1 ENCODE 11.2 +24.7 24672 0.2 MAX YY1 MPC2 DCAF6 ADCY10 GC01P167854
GH01F167933 1.1 Ensembl ENCODE 10 +0.3 336 6.1 CREB3L1 YBX1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MPZL1 DPT MPC2 DCAF6
GH01F167915 0.2 ENCODE 9.9 +20.2 20175 2.7 ELF3 ARID4B THRB ZSCAN9 RAD21 RARA YY1 CREM MIXL1 MXD4 MPC2 ADCY10 DCAF6
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MPC2 on UCSC Golden Path with GeneCards custom track

Promoters for MPC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000286976 669 5600 CREB3L1 YBX1 FEZF1 DMAP1 YY1 ZNF263 SP3 NFYC TBX21 MEF2D

Genomic Location for MPC2 Gene

Chromosome:
1
Start:
167,916,675 bp from pter
End:
167,937,069 bp from pter
Size:
20,395 bases
Orientation:
Minus strand

Genomic View for MPC2 Gene

Genes around MPC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPC2 Gene

Proteins for MPC2 Gene

  • Protein details for MPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95563-MPC2_HUMAN
    Recommended name:
    Mitochondrial pyruvate carrier 2
    Protein Accession:
    O95563
    Secondary Accessions:
    • A8K261
    • Q3SXR6
    • Q6FIF3

    Protein attributes for MPC2 Gene

    Size:
    127 amino acids
    Molecular mass:
    14279 Da
    Quaternary structure:
    • The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2.

neXtProt entry for MPC2 Gene

Post-translational modifications for MPC2 Gene

  • Ubiquitination at Lys 27
  • Modification sites at PhosphoSitePlus

Other Protein References for MPC2 Gene

No data available for DME Specific Peptides for MPC2 Gene

Domains & Families for MPC2 Gene

Protein Domains for MPC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MPC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95563

UniProtKB/Swiss-Prot:

MPC2_HUMAN :
  • Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
Family:
  • Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
genes like me logo Genes that share domains with MPC2: view

No data available for Gene Families for MPC2 Gene

Function for MPC2 Gene

Molecular function for MPC2 Gene

UniProtKB/Swiss-Prot Function:
Mediates the uptake of pyruvate into mitochondria.

Gene Ontology (GO) - Molecular Function for MPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050833 pyruvate transmembrane transporter activity IEA,IBA --
genes like me logo Genes that share ontologies with MPC2: view
genes like me logo Genes that share phenotypes with MPC2: view

Animal Model Products

miRNA for MPC2 Gene

miRTarBase miRNAs that target MPC2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPC2 Gene

Localization for MPC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPC2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MPC2 Gene COMPARTMENTS Subcellular localization image for MPC2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MPC2: view

Pathways & Interactions for MPC2 Gene

genes like me logo Genes that share pathways with MPC2: view

Pathways by source for MPC2 Gene

Interacting Proteins for MPC2 Gene

Gene Ontology (GO) - Biological Process for MPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006850 mitochondrial pyruvate transport IEA --
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate IEA --
GO:1902361 mitochondrial pyruvate transmembrane transport IEA,IBA --
genes like me logo Genes that share ontologies with MPC2: view

No data available for SIGNOR curated interactions for MPC2 Gene

Drugs & Compounds for MPC2 Gene

(1) Drugs for MPC2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
UK-5099 Pharma MCTs and MPC inhibitor, MCT inhibitor; also inhibits of pyruvate transport 0

(1) ApexBio Compounds for MPC2 Gene

Compound Action Cas Number
UK-5099 MCTs and MPC inhibitor 56396-35-1
genes like me logo Genes that share compounds with MPC2: view

Transcripts for MPC2 Gene

Unigene Clusters for MPC2 Gene

Mitochondrial pyruvate carrier 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPC2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: - -
SP3: -
SP4:
SP5: -

Relevant External Links for MPC2 Gene

GeneLoc Exon Structure for
MPC2
ECgene alternative splicing isoforms for
MPC2

Expression for MPC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MPC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MPC2 Gene

This gene is overexpressed in Nasal epithelium (52.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MPC2 Gene



Protein tissue co-expression partners for MPC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MPC2 Gene:

MPC2

SOURCE GeneReport for Unigene cluster for MPC2 Gene:

Hs.517768
genes like me logo Genes that share expression patterns with MPC2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MPC2 Gene

Orthologs for MPC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MPC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRP44 34 35
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia MPC2 35
  • 96 (a)
OneToOne
BRP44 34
  • 93.44 (n)
dog
(Canis familiaris)
Mammalia MPC2 34 35
  • 92.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MPC2 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mpc2 34 16 35
  • 89.33 (n)
oppossum
(Monodelphis domestica)
Mammalia MPC2 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mpc2 34
  • 88.53 (n)
chicken
(Gallus gallus)
Aves BRP44 34 35
  • 76.27 (n)
lizard
(Anolis carolinensis)
Reptilia MPC2 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mpc2 34
  • 72.95 (n)
Str.6574 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15887 34
zebrafish
(Danio rerio)
Actinopterygii mpc2 34 35
  • 71.51 (n)
MPC2 (2 of 2) 35
  • 62 (a)
OneToMany
wufb22g07 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8373 34
fruit fly
(Drosophila melanogaster)
Insecta CG9399 34 35
  • 56.48 (n)
CG9396 35
  • 41 (a)
OneToMany
CG32832 35
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F53F10.3 35
  • 46 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05500g 34
  • 58.78 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL210C 34
  • 50.74 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 35 (a)
OneToMany
FMP43 35
  • 34 (a)
OneToMany
MPC3 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G22310 34
  • 55.56 (n)
rice
(Oryza sativa)
Liliopsida Os07g0449100 34
  • 56.3 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC24B11.09 34
  • 57.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1905 35
  • 52 (a)
OneToMany
CSA.932 35
  • 43 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU03155 34
  • 51.2 (n)
Species where no ortholog for MPC2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPC2 Gene

ENSEMBL:
Gene Tree for MPC2 (if available)
TreeFam:
Gene Tree for MPC2 (if available)

Paralogs for MPC2 Gene

(1) SIMAP similar genes for MPC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MPC2: view

No data available for Paralogs for MPC2 Gene

Variants for MPC2 Gene

Sequence variations from dbSNP and Humsavar for MPC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10489201 -- 167,927,984(+) TACTA(A/G)AAGAT intron-variant
rs10489202 -- 167,933,841(+) ACTCT(G/T)TATGT intron-variant
rs1050036 -- 167,918,198(-) CTAGT(G/T)CTTGA nc-transcript-variant, utr-variant-3-prime
rs1050037 -- 167,918,178(-) AAAAT(A/G)CAGCA nc-transcript-variant, utr-variant-3-prime
rs10918798 -- 167,918,404(+) ATAGA(C/T)AAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPC2 Gene

Variant ID Type Subtype PubMed ID
esv2572362 CNV deletion 19546169
esv32660 CNV loss 17666407
nsv1078878 OTHER inversion 25765185

Variation tolerance for MPC2 Gene

Residual Variation Intolerance Score: 49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MPC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MPC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPC2 Gene

Disorders for MPC2 Gene

Relevant External Links for MPC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MPC2

No disorders were found for MPC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPC2 Gene

Publications for MPC2 Gene

  1. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. (PMID: 22628558) Bricker D.K. … Rutter J. (Science 2012) 2 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  5. Structural characterization of a heterogeneous family of rat brain mRNAs. (PMID: 3022128) Tsou A.P. … Sutcliffe J.G. (Mol. Cell. Biol. 1986) 2 3 64

Products for MPC2 Gene

Sources for MPC2 Gene

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