Aliases for MPC1L Gene
Aliases for MPC1L Gene
External Ids for MPC1L Gene
- HGNC: 44205
- Entrez Gene: 347411
- Ensembl: ENSG00000238205
- UniProtKB: P0DKB6
Previous GeneCards Identifiers for MPC1L Gene
- GC0XP040485
Summaries for MPC1L Gene
GeneCards Summary for MPC1L Gene
MPC1L (Mitochondrial Pyruvate Carrier 1 Like) is a Protein Coding gene. An important paralog of this gene is MPC1.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPC1L Gene
Genomics for MPC1L Gene
Regulatory Elements for MPC1L Gene
Enhancers for MPC1L Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH0XG040643 | 1 | ENCODE | 0.3 | +28.5 | 28474 | 5.6 | HDGF ATF1 PKNOX1 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A ZNF48 GLIS2 | MED14OS CXorf38 MPC1L |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MPC1L on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for MPC1L Gene
- Chromosome:
- X
- Start:
- 40,617,505 bp from pter
- End:
- 40,624,139 bp from pter
- Size:
- 6,635 bases
- Orientation:
- Plus strand
Genomic View for MPC1L Gene
Genes around MPC1L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp11.4 by Ensembl
- Xp11.4 by Entrez Gene
- Xp11.4 by HGNC
MPC1L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MPC1L Gene
Proteins for MPC1L Gene
-
Protein details for MPC1L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0DKB6-MPC1L_HUMAN
- Recommended name:
- Mitochondrial pyruvate carrier 1-like protein
- Protein Accession:
- P0DKB6
Protein attributes for MPC1L Gene
- Size:
- 136 amino acids
- Molecular mass:
- 15138 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for MPC1L Gene
Other Protein References for MPC1L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for MPC1L
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MPC1L
- Origene Custom Protein Services for MPC1L
- Search GeneTex for Proteins for MPC1L
No data available for DME Specific Peptides for MPC1L Gene
Domains & Families for MPC1L Gene
Graphical View of Domain Structure for InterPro Entry
P0DKB6UniProtKB/Swiss-Prot:
MPC1L_HUMAN :- Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
- Family:
-
- Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
No data available for Gene Families and Suggested Antigen Peptide Sequences for MPC1L Gene
Function for MPC1L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0050833 | pyruvate transmembrane transporter activity | IBA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MPC1L
-
- Search ViGene Biosciences for MPC1L
CRISPR Products
-
OriGene CRISPR knockouts for MPC1L
-
Santa Cruz Biotechnology (SCBT) CRISPR for MPC1L
- GenScript: Design CRISPR guide RNA sequences for MPC1L
miRNA Products
- Search ViGene Biosciences for MPC1L
Inhibitory RNA Products
- Search ViGene Biosciences for MPC1L
Clone Products
-
OriGene ORF clones in human for MPC1L
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for MPC1L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MPC1L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MPC1L Gene
Localization for MPC1L Gene
Subcellular locations from UniProtKB/Swiss-Prot for MPC1L Gene
- Membrane; Multi-pass membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0031305 | integral component of mitochondrial inner membrane | IBA | -- |
No data available for Subcellular locations from COMPARTMENTS for MPC1L Gene
Pathways & Interactions for MPC1L Gene
No Data Available
Interacting Proteins for MPC1L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006850 | mitochondrial pyruvate transport | IEA | -- |
| GO:1902361 | mitochondrial pyruvate transmembrane transport | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for MPC1L Gene
Transcripts for MPC1L Gene
mRNA/cDNA for MPC1L Gene
- (1) REFSEQ mRNAs :
- (0) Additional mRNA sequences :
- -
- (2) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MPC1L Gene
CRISPR Products
-
OriGene CRISPR knockouts for MPC1L
-
Santa Cruz Biotechnology (SCBT) CRISPR for MPC1L
- GenScript: Design CRISPR guide RNA sequences for MPC1L
miRNA Products
- Search ViGene Biosciences for MPC1L
Inhibitory RNA Products
- Search ViGene Biosciences for MPC1L
Clone Products
-
OriGene ORF clones in human for MPC1L
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for MPC1L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MPC1L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for MPC1L Gene
mRNA differential expression in normal tissues according to GTEx for MPC1L Gene
This gene is overexpressed in Testis (x52.0).
NURSA nuclear receptor signaling pathways regulating expression of MPC1L Gene:
MPC1LSOURCE GeneReport for Unigene cluster for MPC1L Gene:
Hs.128084Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPC1L Gene
Orthologs for MPC1L Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | LOC520682 34 |
|
||
| dog (Canis familiaris) |
Mammalia | MPC1L 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | RGD1563528 34 |
|
- Species where no ortholog for MPC1L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MPC1L Gene
Variants for MPC1L Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000398916 | -- | 40,623,025(+) | TTTAC(C/G)GCAGT | upstream-variant-2KB | |
| rs1003794941 | -- | 40,623,446(+) | GCCAC(C/G)CGAAG | upstream-variant-2KB | |
| rs1007875655 | -- | 40,622,307(+) | CCATG(C/T)CATGA | upstream-variant-2KB | |
| rs1007929629 | -- | 40,622,861(+) | GCGCA(A/G)AAGTG | upstream-variant-2KB | |
| rs1008882109 | -- | 40,624,136(+) | ATTGA(A/G)CCGAA | utr-variant-3-prime |
Relevant External Links for MPC1L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MPC1L
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MPC1L Gene
Disorders for MPC1L Gene
Relevant External Links for MPC1L
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- MPC1L
No disorders were found for MPC1L Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPC1L Gene
Publications for MPC1L Gene
- MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells. (PMID: 27317664) Vanderperre B. … Martinou J.C. (J. Biol. Chem. 2016) 2 3 64
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
Products for MPC1L Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
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- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MPC1L
- Origene Custom Protein Services for MPC1L
- Browse OriGene Inhibitory RNA Products For MPC1L
- Browse OriGene qPCR primer pairs and template standards
- OriGene CRISPR knockouts for MPC1L
- OriGene ORF clones in human for MPC1L
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MPC1L
- GenScript: Next-day shipping cDNA ORF clone for MPC1L in any vector
- GenScript Custom Purified and Recombinant Proteins Services for MPC1L
- GenScript Custom Assay Services for MPC1L
- GenScript Custom overexpressing Cell Line Services for MPC1L
- GenScript: Design CRISPR guide RNA sequences for MPC1L
- Design optimal peptide antigens
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- Plasmid Preparation
- GenScript Custom Peptide Services for MPC1L
- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
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- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Search GeneTex for Antibodies for MPC1L
- Search GeneTex for Proteins for MPC1L
- Search ViGene Biosciences for MPC1L
- Horizon Cell Lines for MPC1L
- Cyagen custom Knockout/knockin (KOKI) mouse models for MPC1L
- VectorBuilder custom plasmid, inducible vectors for MPC1L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MPC1L
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MPC1L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (122) diseasecard
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- (128) Genetics Home Reference
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- (130) MedlinePlus
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer