MPC1L Gene
protein-coding GIFtS: 24
GCID: GC0XP040485
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Mitochondrial Pyruvate Carrier 1-Like
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Aliases
for MPC1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| Mitochondrial Pyruvate Carrier 1-Like1 2 | | Brain Protein 44-Like Protein 22 | | Mitochondrial Pyruvate Carrier 1-Like Protein2 |
Export aliases for MPC1L gene to outside databases |
Summaries
for MPC1L gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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GeneCards Summary for MPC1L Gene:
MPC1L (mitochondrial pyruvate carrier 1-like) is a protein-coding gene.
|
Genomic Views
for MPC1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | RefSeq DNA sequence:- NC_000023.11 NC_018934.2 NT_079573.5
Regulatory elements:
 Search for regulatory transcription factor binding sites for MPC1L
Other transcription factors
Search Chromatin IP Primers for MPC1L
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MPC1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.4 Ensembl cytogenetic band: Xp11.4 HGNC cytogenetic band: Xp11.4MPC1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP040485: view genomic region
(about GC identifiers)
Start:
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40,482,818 bp from pter |
End:
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40,483,388 bp from pter |
Size:
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571 bases |
Orientation:
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plus strand |
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Proteins
for MPC1L gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MPC1L_HUMAN, P0DKB6 (See
protein sequence)Recommended Name: Mitochondrial pyruvate carrier 1-like protein Size: 136 amino acids; 15138 DaExplore the universe of human proteins at neXtProt for MPC1L: NX_P0DKB6
REFSEQ proteins: NP_001182451.1
MPC1L Human Recombinant
Protein Products:MPC1L Antibody
Products:MPC1L Assay Products: |
Domains /
Families
for MPC1L gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | 1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry P0DKB6 ProtoNet protein and cluster: P0DKB6 UniProtKB/Swiss-Prot: MPC1L_HUMAN, P0DKB6Similarity: Belongs to the mitochondrial pyruvate carrier (MPC) family
MPC1L for domains About GeneDecksing
|
Function
for MPC1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for MPC1L | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for MPC1L  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPC1L |
Localization
for MPC1L gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot MPC1L_HUMAN, P0DKB6: Membrane; Multi-pass membrane protein (Potential)Gene Ontology (GO): 2 cellular component terms: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005743 | mitochondrial inner membrane |
IEA | -- | | GO:0016021 | integral component of membrane |
IEA | -- |
MPC1L for ontologies About GeneDecksing
|
Pathways & Interactions
for MPC1L gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MPC1L
Interactions:
Search GeneGlobe Interaction Network for MPC1L
Gene Ontology (GO): 1 biological process term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006850 | mitochondrial pyruvate transport |
IEA | -- |
MPC1L for ontologies About GeneDecksing
|
Drugs & Compounds
for MPC1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
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 Browse compounds at ApexBio
 Browse Tocris compounds for MPC1L
|
Transcripts
for MPC1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for MPC1L gene: NM_001195522.2 Unigene Cluster for MPC1L: Mitochondrial pyruvate carrier 1-like Hs.128084 [show with all ESTs]Unigene Representative Sequence: CD5580861 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000423387(uc022buz.1)
1 DOTS entry: DT.203697 2 AceView cDNA sequences: AI004294 AA971068
GeneLoc Exon Structure
|
Expression
for MPC1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MPC1L expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
About this image MPC1L Protein expression data from MOPED1, PaxDb2 and
MaxQB3:  --
SOURCE GeneReport for Unigene cluster: Hs.128084
Custom PCR Arrays for MPC1L
Primer
Products: |  | Browse OriGene qPCR
| | | Search Pre-validated RT2 qPCR
Primer Assays in human, mouse, rat MPC1L | | | QuantiTect SYBR Green Assays in human, mouse, rat MPC1L | | | QuantiFast Probe-based Assays in human, mouse, rat MPC1L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPC1L |
Orthologs
for MPC1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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This gene was present in the common ancestor of human and mouse.
Orthologs for MPC1L gene from Selected species (see all 3) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
rat
(Rattus norvegicus) |
Mammalia |
RGD15635281 |
similar to Brain protein 44-like |
77.1(n)
74.75(a) |
|
503429 NM_001109365.1 NP_001102835.1 |
ENSEMBL Gene Tree for MPC1L (if available)
TreeFam Gene Tree for MPC1L (if available) |
Paralogs
for MPC1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for MPC1L gene
2 SIMAP similar genes for MPC1L using alignment to 1 protein entry: MPC1L_HUMAN:MPC1 BRP44L
MPC1L for paralogs About GeneDecksing
|
Genomic Variants
for MPC1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MPC1L (40482818 - 40483388 bp)
Structural Variations
Database of Genomic Variants (DGV) variations for MPC1L: --
| | Site Specific Mutation Identification with PCR Assays |
|
Disorders
/ Diseases
for MPC1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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TryGeneCards Plus | -- |
Publications
for MPC1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for MPC1L gene integrated from 10 sources:
(articles sorted by number of sources associating them with MPC1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
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External Searches for MPC1L gene (in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing MPC1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
Other Databases showing MPC1L gene
(According to HUGE)
About This Section
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Specialized Databases showing MPC1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for MPC1L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for MPC1L gene:
Search GeneIP for patents involving MPC1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MPC1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
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|  | Block miRNA regulation of human, mouse, rat MPC1L using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing MPC1L | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MPC1L | | Predesigned siRNA for gene silencing in human, mouse, rat MPC1L | | | QuantiFast Probe-based Assays in human, mouse, rat MPC1L | | QuantiTect SYBR Green Assays in human, mouse, rat MPC1L | | | Custom PCR Arrays for MPC1L | | Search Chromatin IP Primers for MPC1L | | | Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MPC1L | | Search GeneGlobe Interaction Network for MPC1L | | | Search Regulatory tfbs for MPC1L |
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| | | Search Tocris compounds for MPC1L |
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 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPC1L |
| |  |  |  |  | | | Search ThermoFisher Antibodies for MPC1L |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MPC1L |
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