MPC1L Gene
protein-coding GIFtS: 25
GCID: GC0XP040485
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Mitochondrial Pyruvate Carrier 1-Like
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Aliases
for MPC1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Pyruvate Carrier 1-Like1 2 | | Brain Protein 44-Like Protein 22 | | Mitochondrial Pyruvate Carrier 1-Like Protein2 |
Export aliases for MPC1L gene to outside databases |
Summaries
for MPC1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for MPC1L Gene: 
MPC1L (mitochondrial pyruvate carrier 1-like) is a protein-coding gene.
|
Genomic Views
for MPC1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.2 NT_079573.4
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MPC1L
Other transcription factors
Search SABiosciences Chromatin IP Primers for MPC1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPC1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.4 Ensembl cytogenetic band: Xp11.4 HGNC cytogenetic band: Xp11.4MPC1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP040485: view genomic region
(about GC identifiers)
Start:
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40,482,818 bp from pter |
End:
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40,483,388 bp from pter |
Size:
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571 bases |
Orientation:
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plus strand |
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Proteins
for MPC1L gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
|
UniProtKB/Swiss-Prot: MPC1L_HUMAN, P0DKB6 (See
protein sequence)Recommended Name: Mitochondrial pyruvate carrier 1-like protein Size: 136 amino acids; 15138 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for MPC1L: NX_P0DKB6
MPC1L Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : --
REFSEQ proteins: NP_001182451.1
Human Recombinant Protein Products for MPC1L:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005743 | mitochondrial inner membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
MPC1L for ontologies About GeneDecksing
MPC1L Antibody Products:
Assay Products for MPC1L: |
Protein
Domains /
Families
for MPC1L gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| 1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry P0DKB6 ProtoNet protein and cluster: P0DKB6 UniProtKB/Swiss-Prot: MPC1L_HUMAN, P0DKB6Similarity: Belongs to the mitochondrial pyruvate carrier (MPC) family
MPC1L for domains About GeneDecksing
|
Function
for MPC1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for MPC1L | |  | Search LifeMap BioReagents cell lines for MPC1L | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPC1L |
Pathways & Interactions
for MPC1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MPC1L
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006850 | mitochondrial pyruvate transport |
IEA | -- |
MPC1L for ontologies About GeneDecksing
|
Drugs & Compounds
for MPC1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MPC1L
Search CenterWatch for drugs/clinical trials and news about MPC1L
|
Transcripts
for MPC1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MPC1L gene: NM_001195522.1 Unigene Cluster for MPC1L: Mitochondrial pyruvate carrier 1-like Hs.128084 [show with all ESTs]Unigene Representative Sequence: CD5580861 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000423387(uc022buz.1)
1 DOTS entry: DT.203697 2 AceView cDNA sequences: AI004294 AA971068
GeneLoc Exon Structure
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Expression
for MPC1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MPC1L expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
About this image
SOURCE GeneReport for Unigene cluster: Hs.128084
SABiosciences Custom PCR Arrays for MPC1L
Primer
Products: |  | Browse OriGene qPCR
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MPC1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPC1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPC1L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPC1L |
Orthologs
for MPC1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for MPC1L gene from 1/3 species (see all 3) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
rat
(Rattus norvegicus) |
Mammalia |
RGD15635281 |
similar to Brain protein 44-like |
75.71(n)
73.73(a) |
|
503429 NM_001109365.1 NP_001102835.1 |
ENSEMBL Gene Tree for MPC1L (if available)
TreeFam Gene Tree for MPC1L (if available) |
Paralogs
for MPC1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MPC1L gene
2 SIMAP similar genes for MPC1L using alignment to 1 protein entry: MPC1L_HUMAN:MPC1 BRP44L
MPC1L for paralogs About GeneDecksing
|
Genomic Variants
for MPC1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MPC1L (40482818 - 40483388 bp)
Structural Variations
Database of Genomic Variants (DGV) variations for MPC1L: --
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MPC1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for MPC1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MPC1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with MPC1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
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External Searches for MPC1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MPC1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MPC1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MPC1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MPC1L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MPC1L gene:
Search GeneIP for patents involving MPC1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MPC1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MPC1L | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPC1L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPC1L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPC1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPC1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPC1L |
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| | | | Search Tocris compounds for MPC1L |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPC1L |
|  |  |  |  | | | | Search ThermoFisher Antibodies for MPC1L |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MPC1L |
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