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MPC1 Gene

protein-coding   GIFtS: 49
GCID: GC06M166778

Mitochondrial Pyruvate Carrier 1

(Previous name: brain protein 44-like)
(Previous symbol: BRP44L)
  See MPC1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mitochondrial Pyruvate Carrier 11 2     Brain Protein 44-Like1
BRP44L1 2 3 5     dJ68L15.32
Brain Protein 44-Like Protein2 3     HSPC040 Protein2
MPYCD2 5     

External Ids:    HGNC: 216061   Entrez Gene: 516602   Ensembl: ENSG000000607627   OMIM: 6147385   UniProtKB: Q9Y5U83   
ORGUL members:         

Export aliases for MPC1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MPC1 Gene:
The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate
into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a
cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one
non-protein coding, have been found for this gene. (provided by RefSeq, Aug 2012)

GeneCards Summary for MPC1 Gene:
MPC1 (mitochondrial pyruvate carrier 1) is a protein-coding gene. Diseases associated with MPC1 include mitochondrial pyruvate carrier deficiency, and citrullinemia. GO annotations related to this gene include pyruvate transmembrane transporter activity.

UniProtKB/Swiss-Prot: MPC1_HUMAN, Q9Y5U8
Function: Mediates the uptake of pyruvate into mitochondria




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MPC1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMPC1 promoter sequence
   Search Chromatin IP Primers for MPC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MPC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

MPC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPC1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M166778:  view genomic region     (about GC identifiers)

Start:
166,778,407 bp from pter      End:
166,796,486 bp from pter
Size:
18,080 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MPC1_HUMAN, Q9Y5U8 (See protein sequence)
Recommended Name: Mitochondrial pyruvate carrier 1  
Size: 109 amino acids; 12347 Da
Subunit: The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2 (By similarity)
Sequence caution: Sequence=AAG23822.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2R5I7 Q5TI66 Q9HB67 Q9UQN4

Explore the universe of human proteins at neXtProt for MPC1: NX_Q9Y5U8

Explore proteomics data for MPC1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MPC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257808.1  NP_057182.1  

    ENSEMBL proteins: 
     ENSP00000354223   ENSP00000340784  
    Reactome Protein details: Q9Y5U8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005336 MPC

    Graphical View of Domain Structure for InterPro Entry Q9Y5U8

    ProtoNet protein and cluster: Q9Y5U8

    1 Blocks protein domain: IPB005336 Protein of unknown function UPF0041

    UniProtKB/Swiss-Prot: MPC1_HUMAN, Q9Y5U8
    Similarity: Belongs to the mitochondrial pyruvate carrier (MPC) family


    Find genes that share domains with MPC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPC1_HUMAN, Q9Y5U8
    Function: Mediates the uptake of pyruvate into mitochondria

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0050833pyruvate transmembrane transporter activity IEA--
         
    Find genes that share ontologies with MPC1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MPC1:
     Decreased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MPC1
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    miRNA
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    miRTarBase miRNAs that target MPC1:
    hsa-mir-26b-5p (MIRT030294), hsa-mir-331-3p (MIRT043460)

    Block miRNA regulation of human, mouse, rat MPC1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MPC1
    SwitchGear 3'UTR luciferase reporter plasmidMPC1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MPC1_HUMAN, Q9Y5U8: Mitochondrion inner membrane; Multi-pass membrane protein

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with MPC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MPC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Citric acid cycle (TCA cycle)
    Pyruvate metabolism and Citric Acid (TCA) cycle0.49
    Pyruvate metabolism0.00
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport0.71
    3Glycolysis and gluconeogenesis short map
    Glycolysis and Gluconeogenesis0.60
    4Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with MPC1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MPC1
        Glycolysis and Gluconeogenesis


    1 Reactome Pathway for MPC1
        Pyruvate metabolism


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MPC1
    Interactions:

        Search GeneGlobe Interaction Network for MPC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for MPC1 (Q9Y5U83 ENSP000003542234) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006090pyruvate metabolic process TAS--
    GO:0006850mitochondrial pyruvate transport IEA--
    GO:0008150biological_process ND--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with MPC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MPC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MPC1 gene (2 alternative transcripts): 
    NM_001270879.1  NM_016098.3  

    Unigene Cluster for MPC1:

    Mitochondrial pyruvate carrier 1
    Hs.172755  [show with all ESTs]
    Unigene Representative Sequence: AK310934
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360961(uc021zif.1 uc010kkj.1) ENST00000487218 ENST00000366868
    ENST00000475708 ENST00000341756(uc021zie.1)
    miRNA
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    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MPC1
      QuantiFast Probe-based Assays in human, mouse, rat MPC1

    Additional mRNA sequence: 

    AF125101.1 AF151887.1 AF275811.1 AK310934.1 AK312201.1 BC000810.1 NR_073093.1 

    14 DOTS entries:

    DT.418923  DT.107481  DT.418924  DT.86855307  DT.95281129  DT.100818074  DT.91661935  DT.95281124 
    DT.100646424  DT.40123211  DT.40292740  DT.95281130  DT.99975114  DT.100674744 

    Selected AceView cDNA sequences (see all 259):

    BM714366 CR621401 N74406 N34211 AA922792 AL599267 AI862316 CR591621 
    CA306897 AI339584 CD677586 AA001725 BF939457 AA575996 BE044116 T58854 
    AA459690 H93543 R95919 BM997133 BM455901 AI075801 CR618688 AI089504 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MPC1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:        -     -                                       
    SP2:                                                      
    SP3:              -                                       
    SP4:                          -                           


    ECgene alternative splicing isoforms for MPC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MPC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MPC1 Expression
    About this image


    MPC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Thyroid (Endocrine System)
     
     Colon (Gastrointestinal Tract)
     
     Liver (Hepatobiliary System)
     
     Esophagus (Gastrointestinal Tract)
    MPC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MPC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.172755
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MPC1 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mpc11 , 5 brain protein 44-like5
    mitochondrial pyruvate carrier 11
    89.91(n)1
    94.5(a)1
      17 (4.92 cM)5
    559511  NM_018819.41  NP_061289.11 
     82829045 
    chicken
    (Gallus gallus)
    Aves BRP44L1 brain protein 44-like 81.27(n)
    92.38(a)
      428592  NM_001031524.1  NP_001026695.1 
    lizard
    (Anolis carolinensis)
    Reptilia MPC16
    mitochondrial pyruvate carrier 1
    92(a)
    1 ↔ 1
    1(225901795-225909180)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.60552 Transcribed sequence with moderate similarity to protein more 76.38(n)    AL882085.2 
    zebrafish
    (Danio rerio)
    Actinopterygii mpc11 mitochondrial pyruvate carrier 1 73.97(n)
    84.76(a)
      436671  NM_001002398.2  NP_001002398.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mpc11 Mitochondrial pyruvate carrier 63.23(n)
    65.98(a)
      42268  NM_142505.2  NP_650762.1 
    worm
    (Caenorhabditis elegans)
    Secernentea R07E5.131 R07E5.13 56.7(n)
    56.7(a)
      259500  NM_065493.2  NP_497894.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FMP37(YGL080W)4
    FMP371
    Putative protein of unknown function; highly conserved more4
    FMP371
    58.24(n)1
    57.47(a)1
      7(358636-359028)4
    8528001, 4  NP_011435.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G200901 AT5G20090 59.91(n)
    62.16(a)
      832131  NM_122016.2  NP_197509.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g03730001 Os09g0373000 63.06(n)
    64.86(a)
      4346901  NM_001069564.1  NP_001063029.1 


    ENSEMBL Gene Tree for MPC1 (if available)
    TreeFam Gene Tree for MPC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MPC1 gene
    3 SIMAP similar genes for MPC1 using alignment to 2 protein entries:     MPC1_HUMAN (see all proteins):
    BRP44L    MPC1L    MPC2

    Find genes that share paralogs with MPC1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MPC1
    PGOHUM00000241717


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MPC1 (see all 380)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0680994
    Mitochondrial pyruvate carrier deficiency (MPYCD)4--see VAR_0680992 L H mis40--------
    VAR_0681004
    Mitochondrial pyruvate carrier deficiency (MPYCD)4--see VAR_0681002 R W mis40--------
    rs1998032971,2
    C--164260613(+) TGTGTA/GTGTGT 3 -- int10--------
    rs2002835961,2
    --164260621(+) GTGTG-/TATGTAT 3 -- int10--------
    rs69406321,2
    C,A--164260623(+) tgtgtA/Gtatat 3 -- int10--------
    rs113705681,2
    C--166782045(+) AAAAA-/AGAAAA 3 -- int1 trp30--------
    rs114103291,2
    C--166786232(+) AAAAA-/AGGGGA 3 -- int1 trp31Minor allele frequency- A:0.50NA 2
    rs1128038701,2
    C,F--166787667(+) ATTAGG/TTAGAG 3 -- int11Minor allele frequency- T:0.50CSA 2
    rs1428758801,2
    --166788253(+) TCAGTC/TATTTG 3 -- ds50010--------
    rs1474131061,2
    C--166788587(+) ACTGGC/TCTTCC 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for MPC1 (166778407 - 166796486 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MPC1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MPC1
    DNA2.0 Custom Variant and Variant Library Synthesis for MPC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614738   
    OMIM disorders: 614741  
    UniProtKB/Swiss-Prot: MPC1_HUMAN, Q9Y5U8
  • Mitochondrial pyruvate carrier deficiency (MPYCD) [MIM:614741]: An autosomal recessive metabolic disorder
    characterized by severely delayed psychomotor development, mild dysmorphic features, hepatomegaly, marked
    metabolic acidosis, hyperlactacidemia with normal lactate/pyruvate, and encephalopathy. Some patients have
    epilepsy and peripheral neuropathy. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 2 diseases for MPC1:    
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    mitochondrial pyruvate carrier deficiency    citrullinemia


    Find genes that share disorders with MPC1           About GenesLikeMe


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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MPC1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with MPC1)
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    1. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. (PubMed id 22628558)1, 2, 3 Bricker D.K.... Rutter J. (Science 2012)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    5. Synteny of orthologous genes conserved in mammals, snake, fly, nematode, and fission yeast. (PubMed id 11252172)1, 9 Trachtulec Z. and Forejt J. (Mamm. Genome 2001)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    9. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    10. Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. (PubMed id 17672918)1 Szafranski K....Platzer M. (Genome Biol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51660 HGNC: 21606 AceView: BRP44L Ensembl:ENSG00000060762 euGenes: HUgn51660
    ECgene: MPC1 H-InvDB: MPC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MPC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MPC1 gene:
    Search GeneIP for patents involving MPC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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