MPC1 Gene
protein-coding GIFtS: 48
GCID: GC06M166778
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mitochondrial pyruvate carrier 1(Previous name: brain protein 44-like ) (Previous symbol: BRP44L)
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Aliases for MPC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Mitochondrial Pyruvate Carrier 11 2 | | CGI-1291 | | BRP44L1 2 3 | | Brain Protein 44-Like1 | | DJ68L15.31 | | MPYCD2 | | Brain Protein 44-Like Protein2 3 | | HSPC040 Protein2 |
Export aliases for MPC1 gene to outside databases |
Summaries for MPC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for MPC1: The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate intomitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause ofmitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-proteincoding, have been found for this gene. (provided by RefSeq, Aug 2012) UniProtKB/Swiss-Prot: MPC1_HUMAN, Q9Y5U8Function: Mediates the uptake of pyruvate into mitochondria
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Genomic Views for MPC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for MPC1 Other transcription factors
Search SABiosciences Chromatin IP Primers for MPC1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPC1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27MPC1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M166778: view genomic region
(about GC identifiers)
Start:
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166,778,407 bp from pter |
End:
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166,796,486 bp from pter |
Size:
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18,080 bases |
Orientation:
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minus strand |
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Proteins for MPC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: MPC1_HUMAN, Q9Y5U8 (See
protein sequence)Recommended Name: Mitochondrial pyruvate carrier 1 Size: 109 amino acids; 12347 Da
Subunit: The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2 (By similarity)
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAG23822.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2R5I7 Q5TI66 Q9HB67 Q9UQN4Explore the universe of human proteins at neXtProt for MPC1: NX_Q9Y5U8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y5U8 MPC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001257808.1 NP_057182.1 ENSEMBL proteins: ENSP00000354223 ENSP00000340784 Reactome Protein details: Q9Y5U8 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0005743 | mitochondrial inner membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
MPC1 for ontologies About GeneDecksing
MPC1 Antibody Products: Assay Products for MPC1: |
Protein
Domains / Families for MPC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MPC1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y5U8ProtoNet protein and cluster: Q9Y5U8 1 Blocks protein family: IPB005336 Protein of unknown function UPF0041
UniProtKB/Swiss-Prot: MPC1_HUMAN, Q9Y5U8Similarity: Belongs to the mitochondrial pyruvate carrier (MPC) family |
Function for MPC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: MPC1_HUMAN, Q9Y5U8Function: Mediates the uptake of pyruvate into mitochondria
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPC1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPC1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for MPC1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MPC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPC1  |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0050833 | pyruvate transmembrane transporter activity |
IEA | -- |
MPC1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MPC1:
|
Pathways & Interactions for MPC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Pyruvate metabolism | | | 2 | Metabolism | | | 3 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 4 | TCA Cycle | | | 5 | Glycolysis and gluconeogenesis (short map) | |
Pathway sources See GeneCards unified pathways Show all pathways
1 BioSystems Pathway for MPC1 
4
Reactome Pathways for MPC1
MPC1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MPC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
 5/40 Interacting proteins for MPC1 (Q9Y5U83 ENSP000003542234) via UniProtKB, MINT, STRING, and/or I2D (see all 40)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
MPC1 for ontologies About GeneDecksing
|
Drugs & Compounds for MPC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for MPC1 Search CenterWatch for drugs/clinical trials and news about MPC1 
|
Transcripts for MPC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for MPC1 gene (2 alternative transcripts): NM_001270879.1 NM_016098.3 Unigene Cluster for MPC1: Mitochondrial pyruvate carrier 1 Hs.172755 [show with all ESTs]Unigene Representative Sequence: AK3109345 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000360961(uc021zif.1 uc010kkj.1) ENST00000487218 ENST00000366868 ENST00000475708 ENST00000341756(uc021zie.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPC1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPC1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for MPC1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MPC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPC1  |
Additional cDNA sequence: AF125101.1 AF151887.1 AF275811.1 AK310934.1 AK312201.1 BC000810.1 NR_073093.1 14 DOTS entries: DT.418923 DT.107481 DT.418924 DT.86855307 DT.95281129 DT.100818074 DT.91661935 DT.95281124 DT.100646424 DT.40123211 DT.40292740 DT.95281130 DT.100674744 DT.99975114 24/259 AceView cDNA sequences (see all 259): AA575996 AI089504 CA306897 BM455901 AA922792 AA001725 AI339584 CR618688 BM842280 N74406 CR621401 CR591621 BM788167 AA459690 AI075801 H93543 BF939457 R95919 CD677586 BM714366 AI862316 N34211 BE044116 BM997133 GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for MPC1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | |
| SP1: | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for MPC1
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Expression for MPC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot CGAP TAG: --
See MPC1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MPC1
SOURCE GeneReport for Unigene cluster: Hs.172755 SABiosciences Custom PCR Arrays for MPC1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPC1 Browse OriGene validated miRNA SYBR primer pairs
| |  | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MPC1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPC1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPC1 |
Orthologs for MPC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MPC1 gene from 9/33 species (see all 33) About this table
ENSEMBL Gene Tree for MPC1 (if available) TreeFam Gene Tree for MPC1 (if available)  |
Paralogs for MPC1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for MPC1 gene
3 SIMAP similar genes for MPC1 using alignment to 2 protein entries: MPC1_HUMAN (see all proteins):BRP44L MPC1L MPC2
MPC1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MPC1 PGOHUM00000241717
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Genomic Variants for MPC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 6 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for MPC1 (166778407 - 166796486 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MPC1: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPC1 |
|
Disorders
/ Diseases for MPC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MPC1 for disorders About GeneDecksing
OMIM gene information: 614738
OMIM disorders: --
UniProtKB/Swiss-Prot: MPC1_HUMAN, Q9Y5U8
Defects in MPC1 are the cause of mitochondrial pyruvate carrier deficiency (MPYCD) [MIM:614741]. An autosomalrecessive metabolic disorder characterized by severely delayed psychomotor development, mild dysmorphic features,hepatomegaly, marked metabolic acidosis, hyperlactacidemia with normal lactate/pyruvate, and encephalopathy. Somepatients have epilepsy and peripheral neuropathy 1 disease for MPC1: About MalaCardsmalaria Export disorders for MPC1 gene to outside databases
|
Publications for MPC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MPC1 gene, integrated from 9 sources (see all 14): (articles sorted by number of sources associating them with MPC1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, drosophila, and humans. (PubMed id 22628558)1, 2, 3 Bricker D.K.... Rutter J. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Synteny of orthologous genes conserved in mammals, snake, fly, nematode, and fission yeast. (PubMed id 11252172)1, 9 Trachtulec Z. and Forejt J. (2001)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)1 Wheeler H.E....Kim S.K. (2009)
- Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. (PubMed id 17672918)1 Szafranski K....Platzer M. (2007)
|
External Searches for MPC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing MPC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MPC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MPC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for MPC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MPC1 gene: Search GeneIP for patents involving MPC1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for MPC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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 | |
 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for MPC1 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPC1 | | OriGene Protein Over-expression Lysate for MPC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for MPC1 | | OriGene 3'-UTR Clone for MPC1 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPC1 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | OriGene Purified Protein for MPC1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MPC1 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPC1 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPC1 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPC1 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPC1 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPC1 |
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| | | Search Tocris compounds for MPC1 |
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 | | MPC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | ThermoFisher Antibodies for MPC1 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPC1 |
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